CURRICULUM VITAE
Michael W. Lawlor MD, PhD
Michael W. Lawlor MD, PhD
Adjunct Professor
Department of Pathology
Division of Pediatric Pathology
Department of Pathology
Division of Pediatric Pathology
OFFICE ADDRESS: |
Children's Research Institute |
9000 W Wisconsin Ave |
Milwaukee, WI 53226 |
EDUCATION: |
1993 - 1996 B.S., Marquette University, Milwaukee, WI |
1997 - 2004 M.D., Ph.D., Loyola University Chicago, Maywood, IL |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
07/2004 - 06/2006 Resident, Pathology, Anatomic Pathology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit St, Boston, MA 02114 |
07/2006 - 06/2008 Fellow, Pathology, Neuropathology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit St., Boston, MA 02114 |
07/2008 - 08/2011 Research Fellow, Medicine, Genetics/Genomics, Children's Hospital Boston/Harvard Medical School, 300 Longwood Ave, Boston, MA 02115 |
FACULTY APPOINTMENTS: |
09/2011 - Present Associate Professor, Pathology, Pediatric Pathology, Children's Hospital of Wisconsin/ Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
2011 - 2016 Assistant Professor, Pathology, Children's Hospital of Wisconsin/ Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
ADMINISTRATIVE APPOINTMENTS: |
2017 - Present Associate Director, Neuroscience Research Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
2011 - Present Director, Pediatric Pathology Clinical Neuromuscular Laboratory, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
2016 - Present Medical Director, Neuromuscular Pathology Laboratory, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
HOSPITAL STAFF PRIVILEGES: |
09/2011 - Present Pathology, Pediatric Pathology, Children's Hospital of Wisconsin/ Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
2015 - Present Pathology, Froedtert Memorial Lutheran Hospital/ Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226 |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
Anatomic Pathology | 09/2009 | 09/2019 |
Neuropathology | 09/2009 | 09/2019 |
AWARDS AND HONORS: |
1996 - Present Phi Beta Kappa |
07/2001 - 06/2002 Schmitt Dissertation Fellowship, Loyola University Chicago |
2008 - Present Travel Award (declined due to scheduling conflict with Neuropathology Board Exam), World Muscle Society |
2010 - 2015 K08 Mentored Clinical Scientist Development Award, NIAMS |
2011 - Present Travel Award, American Association of Neuropathologists |
2012 - Present 2013 Top-Rated Doctors list, M Magazine |
2012 - Present Weil Award for Best Paper in Experimental Neuropathology, American Association of Neuropathologists |
2012 - Present Best Basic Science Junior Faculty Poster, Medical College of Wisconsin |
2015 - Present Teaching Excellence Award, Medical College of Wisconsin |
2015 - 2018 Presidential Faculty Scholar Award, Medical College of Wisconsin |
2016 - Present Medical College of Wisconsin Leadership Academy, Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2005 - Present College of American Pathologists (Member) |
2008 - Present World Muscle Society (Member) |
2009 - Present American Association of Neuropathologists (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
1999 - 2002 Elsevier/Harcourt Health Sciences |
Editorial Board |
2016 - Present Muscle and Nerve |
Ad-Hoc Reviewer |
2011 - Present Muscle and Nerve |
2011 - Present Journal of Biomedicine and Biotechnology |
2013 - Present Journal of Histochemistry and Cytochemistry |
2013 - Present Journal of the Peripheral Nervous System |
2013 - Present Human Molecular Genetics |
2015 - Present Journal of Cell Science |
2015 - Present Acta Neuropathological Communications |
2016 - Present Journal of Molecular and Cellular Cardiology |
2017 - Present Journal of Neuropathology and Experimental Neurology |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2012 - Present Neuropathology Representative, National Institute of Neurological Disease and Stroke (NINDS) Adult Neuromuscular Disease Common Data Elements (CDE) Working Group |
2013 - 2014 Coordinator/Presenter, American Association of Neuropathologists (AANP) Conference |
2015 - Present Committee Member, 2015 American Association of Neuropathologists (AANP) Program Committee |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Translation to Clinical Trial for Gene Therapy of Humans with X-linked Myotubular Myopathy, Audentes Therapeutics Neuromuscular Advisory Board, London, England, United Kingdom, 01/29/2015 - 01/30/2015 |
What is a Tissue Bank and How Can It Help in the Preparation for Clinical Trials?, European Family Conference on Myotubular Myopathy and Other Centronuclear Myopathies, 05/07/2016 |
The role of skeletal muscle pathology in the translation of gene therapy for congenital muscle disease., University of Western Australia, Perth, Australia, 11/22/2016 |
SEPN1-Associated Pathology, International Conference on SEPN1-Related Myopathies, Arlington, Virginia, United States, 05/15/2017 |
Muscle Biopsy and Autopsy Planning in ASPIRO, Audentes Therapeutics ASPIRO Clinical Trial Investigator Meeting, Orlando, Florida, United States, 06/28/2017 |
Collection and Evaluation of Liver Biopsy Tissue in VALENS, Audentes Therapeutics VALENS Clinical Trial Investigator Meeting, Charlotte, North Carolina, United States, 07/12/2017 |
Diagnosis and Microdystrophin Gene Therapy for Duchenne Muscular Dystrophy, Hippo Signaling in Neuro- and Muscular Biology Symposium, Milwaukee, Wisconsin, United States, 09/22/2017 |
National |
Taking the USMLE Step 2 Exam, Invited Lecture, Loyola University, Chicago, Illinois, United States, 07/2007 |
Pumping up the myotubularin-deficient mouse: A pre-clinical trial for congenital myopathy, Invited Lecture, University of Pittsburgh Medical Center, Neuropathology Division, Pittsburgh, Pennsylvania, United States, 05/2009 |
Pumping up the myotubularin-deficient mouse: A pre-clinical trial for congenital myopathy, Invited Lecture, Marquette University, Biology Department, Milwaukee, Wisconsin, United States, 04/2010 |
Pumping up the myotubularin-deficient mouse: A pre-clinical trial for congenital myopathy, Invited Lecture, Children’s Hospital of Wisconsin, Milwaukee, Wisconsin, United States, 02/2011 |
Advances in Emerging Treatments for X-Linked Myotubular Myopathy, Invited Lecture, Loyola University, Department of Physiology, Chicago, Illinois, United States, 07/2012 |
Emerging treatments for X-linked myotubular myopathy, Invited Lecture, University of Kentucky, Lexington, Lexington, Kentucky, United States, 03/2013 |
Congenital Muscle Disease Consortium International Workshop, Working conference devoted to the development and publication of standard operating procedures for research studies in the congenital muscle disease field, Washington, D.C., United States, 04/21/2013 |
The Integration of Biomarker Discovery Projects in the Field of Congenital Muscle Disease, Congenital Muscle Disease Biomarker Meeting, Pacific Grove, California, United States, 10/01/2013 |
Nemaline Myopathy Building Muscle Initiative Workshop, Stanford University, Stanford, California, United States, 10/06/2013 |
Disorders of Peripheral Nerve and Muscle Symposium, Canadian Association of Neuropathologists 2013 Meeting, 10/19/2013 |
Emerging Treatments for X-linked Myotubular Myopathy, Nationwide Children’s Hospital Center for Gene Therapy, 11/07/2013 |
Satellite Session of the New Directions in Biology and Disease of Skeletal Muscle 2014 Conference, Titin Myopathy Workshop, Chicago, Illinois, United States, 2014 |
Emerging Treatments for X-linked Myotubular Myopathy, Invited Lecture, University of Minnesota Wellstone Muscular Dystrophy Center, Minneapolis, Minnesota, United States, 02/27/2015 |
Disease Pathology and Endpoint Identification in Treatment Trials for X-linked Myotubular Myopathy, Invited Lecture, Audentes Therapeutics, San Francisco, California, United States, 06/30/2015 |
Overview of Pre-clinical Studies in X-linked Myotubular Myopathy and Nemaline Myopathy, Invited Speaker, Solid Biosciences, Cambridge, Massachusetts, United States, 02/09/2016 |
Issues Related to Kernicterus in the Study of Crigler-Najjar Syndrome, Invited Speaker, Audentes Therapeutics, San Francisco, California, United States, 06/24/2016 |
Studying disease processes and potential treatments for nemaline myopathy, Nemaline Myopathy 2016 Patient and Family Conference, 07/09/2016 |
Overview of Lawlor Laboratory Projects, Invited Speaker, Audentes Therapeutics, San Francisco, California, United States, 08/30/2016 |
Evaluating dystrophin expression in the planning of clinical trials, Invited Speaker, Solid Biosciences, Scientific Advisory Board, Cambridge, Massachusetts, United States, 09/29/2016 |
Issues related to kernicterus in the study of Crigler-Najjar syndrome, Invited Speaker, Audentes Therapeutics, San Francisco, California, United States, 11/08/2016 |
What do we do if a patient dies in ASPIRO? Autopsy planning in deceased study patients, Invited Speaker, Audentes Therapeutics, Board of Scientific and Clinical Advisors, San Francisco, California, United States, 03/13/2017 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Dastgir J, Rutkowski A, Alvarez R, Cossette S, Yan K, Hoffmann R, Hayashi Y, Goebel HH, Bonnemann C, Lawlor MW, Integration of common data elements into muscle biopsy reporting, 2013 Muscular Dystrophy Association National Scientific Conference, 04/21/2013 - 04/24/2013 |
Dastgir J, Rutkowski A, Alvarez R, Cossette S, Yan K, Hoffmann R, Hayashi Y, Goebel HH, Bonnemann C, Lawlor MW, Integration of common data elements into muscle biopsy reporting, American Association of Neuropathologists Meeting, 06/20/2013 - 06/23/2013 |
Dastgir J, Rutkowski A, Alvarez R, Cossette S, Yan K, Hoffmann R, Hayashi Y, Goebel HH, Bonnemann C, Lawlor MW, Integration of common data elements into muscle biopsy reporting, 2013 Canadian Association of Neuropathologists Meeting, 08/16/2013 - 08/19/2013 |
Dastgir J, Rutkowski A, Alvarez R, Cossette S, Yan K, Hoffmann R, Hayashi Y, Goebel HH, Bonnemann C, Lawlor MW, Integration of common data elements into muscle biopsy reporting, 2013 World Muscle Society Conference, 10/01/2013 - 10/05/2013 |
National |
Lawlor MW, Grange RW, Edelstein RV, Shelton GD, Pierson CR, Buj Bello A, Tegeler C, Childers MK, Beggs AH, Impaired contractile properties in myotubularin deficient mice and dogs, 2010 New Directions in Biology and Disease of Skeletal Muscle Meeting, Ottawa, Canada, 05/05/2010 - 05/08/2010 |
Lawlor MW, Viola MG, Edelstein RV, Pierson CR, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH, Responses to treatment are dependent on fiber type and mutation in murine models of myotubularin deficiency, 2011 Muscular Dystrophy Association National Scientific Conference, Las Vegas, Nevada, United States, 03/13/2011 - 03/16/2011 |
Lawlor MW, Viola MG, Edelstein RV, Pierson CR, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH, Responses to treatment are dependent of fiber type, muscle, and mutation in murine models of myotubularin deficiency, 2011 American Association of Neuropathologists Meeting, Seattle, Washington, United States, 06/23/2011 - 06/26/2011 |
Lawlor MW, Viola MG, Widrick JJ, Grange RW, Buj-Bello A, Pierson CR, Beggs AH, Distribution and extent of weakness is dependent on fiber type and mutation in murine models of myotubularin deficiency, 2011 American Association of Neuropathologists Meeting, Seattle, Washington, United States, 06/23/2011 - 06/26/2011 |
Lawlor MW, Viola MG, Meng H, Edelstein RV, Pierson CR, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH, Responses to ActRIIB-mFc treatment are specific to individual muscles in the Mtm1p.R69C model of myotubularin deficiency, 2012 New Directions in Biology and Disease of Skeletal Muscle Meeting, 06/17/2012 - 06/21/2012 |
Lawlor MW, Alexander MS, Viola MG, Meng H, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Joubert R, Buj Bello A, Kunkel LM, Beggs AH, Gussoni E, Satellite cell depletion and dysfunction correlates with disease progression in severe murine myotubularin deficiency, 2012 New Directions in Biology and Disease of Skeletal Muscle Meeting, 06/17/2012 - 06/21/2012 |
Lawlor MW, Armstrong D, Viola MG, Meng H, Buj-Bello A, Hsu CP, Pierson CR, Childers MK, Grange RW, Widrick JJ, Beggs AH, Ultrastructural pathology and functional deficits can be reversed following enzyme replacement in myotubularin deficient mice, 2012 New Directions in Biology and Disease of Skeletal Muscle Meeting, 06/17/2012 - 06/21/2012 |
Lawlor MW, Armstrong D, Viola MG, Meng H, Buj-Bello A, Hsu CP, Pierson CR, Childers MK, Grange RW, Widrick JJ, Beggs AH, Ultrastructural pathology and functional deficits can be reversed following enzyme replacement in myotubularin deficient mice, 2012 American Association of Neuropathologists Meeting, 06/21/2012 - 06/24/2012 |
Lawlor MW, Alexander MS, Viola MG, Meng H, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Joubert R, Buj Bello A, Kunkel LM, Beggs AH, Gussoni E, Satellite cell depletion and dysfunction correlates with disease progression in severe murine myotubularin deficiency, 2012 American Association of Neuropathologists Meeting, 06/21/2012 - 06/24/2012 |
Lawlor MW et al, Gene replacement therapy improves muscle function and pathology in murine and canine models of X-linked myotubular myopathy, 2013 American Association of Neuropathologists Meeting, 06/20/2013 - 06/23/2013 |
Lawlor MW et al, Treatment with ActRIIB-mFc Improves Lifespan, Behavior, and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy, 2014 American Association of Neuropathologists Meeting, 06/11/2014 - 06/14/2014 |
Lawlor MW et al., Treatment with ActRIIB-mFc Improves Lifespan, Behavior, and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy, 2014 New Directions in Biology and Disease of Skeletal Muscle 2014 Conference, 06/29/2014 - 07/02/2014 |
Tinklenberg J, Meng H, Yang L, Hardeman EC, Pearsall S, Fitts RH, Lawlor MW et al., Treatment with ActRIIB-mFc produces myofiber growth and improves lifespan in the Acta1 H40Y murine model of nemaline myopathy, 2015 Muscular Dystrophy Association National Scientific Conference, 03/11/2015 - 03/14/2015 |
Lawlor MW et al., AAV8-MTM1 results in long-term survival and correction of severe muscle pathology in a canine model of X-linked myotubular myopathy, 2015 American Association of Neuropathologists Meeting, 06/11/2015 - 06/14/2015 |
Tinklenberg J, Meng H, Yang L, Hardeman EC, Pearsall S, Fitts RH, Lawlor MW et al., Treatment with ActRIIB-mFc produces myofiber growth and improves lifespan in the Acta1 H40Y murine model of nemaline myopathy, 2015 American Association of Neuropathologists Meeting, 06/11/2015 - 06/14/2015 |
Lawlor MW et al., Muscle contractures can be modeled in the mouse through limb immobilization during early life, allowing the evaluation of therapeutic strategies, 2016 American Association of Neuropathologists Meeting, 06/18/2016 |
Lawlor MW et al., Muscle contractures can be modeled in the mouse through limb immobilization during early life, allowing the evaluation of therapeutic strategies, 2016 New Directions in the Biology and Disease of Skeletal Muscle Conference, 06/29/2016 - 07/02/2016 |
Lawlor MW et al., Restoration of truncated dystrophin expression with AAV-microdystrophin in the mouse model of Duchenne muscular dystrophy, 2017 American Association of Neuropathologists Meeting, 06/09/2017 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2014 - Present Council Member, Molecular Medicine Pathway Curriculum Approval Committee, Physician-Scientist Pathway in the Medical School, Molecular Medicine, Medical College of Wisconsin |
2017 - Present Associate Director, Neuroscience Research Center Board of Directors, Medical College of Wisconsin |
Hospital |
2011 - Present Clinical Laboratory Director (member), Laboratory Quality Management Committee, Quality Management, Children's Hospital of Wisconsin |
2013 - Present Member, Nelson's Undiagnosed and Rare Disease Group, Children's Hospital of Wisconsin |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
02/2014 - Present M2 Discovery Curriculum; separate two-hour lectures were given on the topics of Metabolic Nervous System Disease, Neuromuscular Disease, and Malformations of the Central Nervous System. This involves 6 hours of teaching per year. |
01/2015 - Present M1 Physician Scientist Pathway Small Group Facilitator. Four two-hour sessions (per year) were facilitated during which M1 students participate in research-relevant discussions and exercises. This involves 8 hours of teaching per year. |
Graduate Student Education |
2012 Physiology Department Seminar Series; “Emerging Treatments in X-Linked Myotubular Myopathy.” |
2012 Biochemistry Department Seminar Series; “Emerging Treatments in X-Linked Myotubular Myopathy.” |
2012 Cell Biology Department Seminar Series; “Emerging Treatments in X-Linked Myotubular Myopathy.” |
2012 Clinical and Translational Science Institute (CTSI) Seminar Series; “Emerging Treatments in X-Linked Myotubular Myopathy.” |
2012 - 2013 Neuroscience Research Center (NRC) Research in Progress Seminar; Dissecting mechanisms of treatment efficacy in X-linked myotubular myopathy (60 minutes). |
2017 Mechanisms of Cellular Signaling Course; “Cell Signaling in Skeletal Muscle"; this was a 90 minute presentation to a large graduate school group, detailing key processes in skeletal muscle and describing how specific disease states interfere with these processes. |
Resident and Fellow Education |
2012 - Present “Pathological classification of surgical resections for epilepsy.” This is a 1 hour talk that is given yearly to neurology residents and fellows. |
2012 - Present “Pathological Evaluation of Skeletal Muscle.” This is a 60-90 minute lecture (depending on department) that is given to residents/fellows in the neurology department, pediatric neurology fellowship, or pathology residency program yearly. Depending on the lecture schedule, I give this talk to residents 2-3 times per year. |
2013 - Present “Pathological Features of Brain Tumors.” This is a 60 minute talk that is given yearly to the pediatric neurology fellows. |
10/14/2014 “Emerging Treatments in X-Linked Myotubular Myopathy and Nemaline Myopathy.” This was a 60 minute talk about our research at the Pediatric Surgery Multidisciplinary Research Conference. |
2017 - Present “Neuropathology Boot Camp”: This is a two-week focused session for pediatric neurology fellows, neurosurgical residents, and neuroradiology fellows that reviews key issues of neuropathology for exam preparation. The sessions are 90-120 minutes each, and 6 sessions are scattered over a two week period. This educational session is offered yearly. |
Continuing Medical Education |
01/22/2012 “Pathological classification of surgical resections for epilepsy.” This was a 1-hour talk delivered at the weekly Refractory Epilepsy Conference. Audience included residents, fellows, staff, and faculty from the neurology, neurosurgery, and radiology departments. |
09/04/2015 Physical Medicine and Rehabilitation Grand Rounds. “Emerging Treatments in X-Linked Myotubular Myopathy and Nemaline Myopathy.” Audience included faculty, staff, residents, medical students, and graduate students associated with the Physical Medicine and Rehabilitation program at the Medical College of Wisconsin. |
05/05/2017 Department of Pathology Grand Rounds. “The Role of Skeletal Muscle Pathology in the Translation of Gene Therapy for Congenital Muscle Disease.” Audience included faculty, staff, residents, medical students, and graduate students associated with the Pathology Department at the Medical College of Wisconsin. |
05/24/2017 Department of Cell Biology Grand Rounds. “The Role of Skeletal Muscle Pathology in the Translation of Gene Therapy for Congenital Muscle Disease.” Audience included faculty, staff, residents, medical students, and graduate students associated with the Cell Biology Department at the Medical College of Wisconsin. |
Community/Lay Public |
10/10/2013 Neuroscience Research Center (NRC) Donor Reception; “Emerging Treatments for X-Linked Myotubular Myopathy.” This was a talk about our research to interested members of the lay community who were attending a donor reception for the NRC at the Medical College of Wisconsin. |
05/16/2017 Neuroscience Research Center Board of Directors Meeting; “Usefulness of Pathology in the Study of Gene Therapy for Congenital Muscle Disease.” This was a 30 minute talk outlining our nonclinical work in the fields of gene therapy for XLMTM and Duchenne muscular dystrophy and outlining our plan to collaboratively translate our studies to the human clinical trial stage. |
EXTRAMURAL TEACHING: |
Medical Student Education |
1999 - 2002 Loyola University, Chicago, Medical Neuroanatomy Course; Lab instructor and problem-based learning facilitator |
2001 - 2002 Loyola University, Chicago, Medical Physiology Course; Problem-based learning facilitator. |
2006 - 2007 Harvard Medical School, Medical Neuroanatomy Course; Neuroanatomy lab instructor |
Continuing Medical Education |
04/20/2012 Children's Research Institute, Conference; “Evaluating Treatments for X-Linked Myotubular Myopathy.” Audience included faculty, staff, residents, medical students, and graduate students associated with Children’s Research Institute. |
07/13/2012 Children's Hospital of Wisconsin, Grand Rounds; “Advances in Emerging Treatments for X-Linked Myotubular Myopathy.” Audience included faculty, staff, residents, medical students, and graduate students associated with Children’s Hospital of Wisconsin. |
09/2013 Children's Research Institute, Conference; “Advances in Emerging Treatments for X-Linked Myotubular Myopathy.” Audience included faculty, staff, residents, medical students, and graduate students associated with Children’s Research Institute. |
05/15/2015 Children's Research Institute, Conference; “Emerging Treatments in X-Linked Myotubular Myopathy and Nemaline Myopathy.” Audience included faculty, staff, residents, medical students, and graduate students associated with Children’s Research Institute. |
08/28/2015 Children's Hospital of Wisconsin, Grand Rounds; “Emerging Treatments in X-Linked Myotubular Myopathy and Nemaline Myopathy.” Audience included faculty, staff, residents, medical students, and graduate students associated with Children’s Hospital of Wisconsin. |
Community/Lay Public |
2012 Cure CMD, Pathological Evaluation of Skeletal Muscle. This was a 1-hour talk given during a staff meeting. The audience included physicians, employees, and volunteers of Cure CMD. This session was given remotely over teleconference. |
07/25/2013 - 07/27/2013 Myotubular Myopathy/Centronuclear Myopathy 2013 Family Conference, I gave one 30-minute talk to a group of patients, families and medical professionals called “Enzyme/Protein Replacement for X-Linked Myotubular Myopathy” and another 30-minute talk to the same group called “The Congenital Muscle Disease Tissue Repository.” |
01/25/2014 Muscular Dystrophy Association of Wisconsin, Muscular Dystrophy Association Wisconsin Muscle Summit. “Emerging Treatments for X-Linked Myotubular Myopathy.” This was a 30 minute talk about our research at a local patient and family conference for patients with neuromuscular disease. Audience members included patients and families affected by neuromuscular disease. I also participated in an hour-long Question and Answer session at the end of this summit. |
10/24/2014 Congenital Muscle Disease Tissue Repository Family Site Visit, This was a 1 hour talk that was given to patients and families with congenital muscle disease to educate them about our research and tissue banking procedures. |
12/08/2014 Nemaline Myopathy Patient and Parent Group Webinar, “Nemaline Myopathy: An Update for Patients, Families, and Caregivers.” This was a 60 minute webinar that was given to patients, families, and organizations affected by nemaline myopathy. |
07/24/2015 - 07/26/2015 Myotubular Myopathy/Centronuclear Myopathy (MTM-CNM) 2015 Family Conference, This was a 3 day family conference with patient contact events and scientific presentations. I participated in a 120 minute “Scientific and Medical Forum” which served as a question/answer session for patients, and did a 20 minute presentation entitles “CMD Tissue Repository and Adapting canine pathology studies for gene therapy in clinical trials” as a summary of the work in our lab that is affected most directly by patient tissue donations. |
02/29/2016 Wisconsin Rare Disease Day 2016, Invited Speaker; “Gene Therapy for X-linked myotubular myopathy.” I gave a brief talk to patients and lawmakers at the Wisconsin State Capitol building about canine preclinical gene therapy studies for X-linked myotubular myopathy. |
PROGRAMMATIC DEVELOPMENTS: |
Clinical Programs |
11/2011 - Present Establishment of the Pediatric Pathology Clinical Neuromuscular Laboratory |
03/2016 - Present Establishment of MCW Neuromuscular Pathology Laboratory. |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Lawlor MW, Holve S, and Stubbs Jr. EB. Assessment of serum mediated neurotoxicity in Navajo neuropathy. Electromyogr. Clin. Neurophysiol. 2000;40:211-214. PMID 10907598 |
2. Lawlor MW, Richards MP, Fisher MA, and Stubbs Jr. EB. Sensory nerve conduction deficit in experimental monoclonal gammopathy of undetermined significance (MGUS) neuropathy. Muscle Nerve 2001;24:809-816. PMID 11360265 |
3. Lawlor MW, Richards MP, De Vries GH, Fisher MA, Stubbs Jr. EB. Antibodies to L-periaxin in sera of patients with peripheral neuropathy produce experimental sensory nerve conduction deficits. J. Neurochem. 2002;83:1-9. PMID 12390521 |
4. Stubbs Jr. EB, Lawlor MW, Richards MP, Sidiqqui K, Fisher MA, Bhoopalam N and Siegel GJ. Anti-Neurofilament antibodies in MGUS neuropathy produce experimental motor nerve conduction block. Acta Neuropathol (Berl). 2003 Feb;105(2):109-16. PMID 12536221 |
5. Lawlor MW, Nielsen GP, Louis DN. Malignant solitary fibrous tumour of the meninges with marked amianthoid fibre deposition. Neuropathol Appl Neurobiol. 2008 Oct;34(5):569-72. Epub 2008 Feb 21. PMID 18298634 |
6. George PM, Saigal R, Lawlor MW, Moore MJ, Lavan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov;91(2):519-27. PMID 18985787 |
7. Simons EJ, Bellas E, Lawlor MW, Kohane DS. Effect of Chemical Permeation Enhancers on Nerve Blockade. Mol Pharm. 2009 Jan-Feb;6(1):265-73. PMID 19105721 |
8. Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28: 106(17):7125-30. PMID 19365067 |
9. Lawlor MW*, DeChene ET*, Roumm E, Geggel AS, Moghadaszadeh B, Beggs AH. Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion. Hum Mutat. 2010 Feb;31(2):176-83.PMID 19953533 |
10. Kheir JN*, Lawlor MW*, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatric and Developmental Pathology. 2010 Sep-Oct;13(5):397-403.PMID 20158377 |
11. Markert CD, Meaney MP, Voelker KA, Grange RW, Dalley HW, Cann JK, Ahmed M, Bishwokarma B, Walker SJ, Yu SX, Brown M, Lawlor MW, Beggs AH, Childers MK. Analysis of skeletal muscle function in TCAP knockout mice. Hum Mol Genet. 2010 Jun 1;19(11):2268-83. PMID 20233748 |
12. Zhou Y*, Cheunsuchon P*, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Bronson R, Zhang X, Gorden FE, Lidov HGW, Klibanski A. Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52. PMID 20610486 |
13. Lawlor MW, Read B, Edelstein R, Yang N, Pierson CR, Stein MJ, Wermer-Colan A, Buj Bello A, Lachey JL, Seehra J, Beggs AH. Inhibition of the activin receptor type IIB increases strength and lifespan in myotubularin deficient mice. The American Journal of Pathology. 2011 Feb;178(2):784-793. PMID 21281811 |
14. Ottenheijm CA, Lawlor MW, Stienen GJ, Granzier H, Beggs AH. Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. Hum Molec Genet, 2011, 20:2015-25. PMID 21357678 |
15. Mizrahi B, Stefanescu CF, Yang C, Lawlor MW, Ko D, Langer RS, Kohane DS. Elasticity and Safety of Alkoxyethyl Cyanoacrylate Tissue Adhesives. Acta Biomaterialia, 2011; 3150-7. PMID 21569875 |
16. Lawlor MW, Ottenheijm CA, Lehtokari VL, Cho K, Pelin K, Wallgren-Pettersson C, Granzier H, Beggs AH. Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy. Skeletal Muscle, 2011; 1(1):23.PMID 21798101 |
17. Jeong KJ, Wang LQ, Stefanescu CF, Lawlor MW, Polat J, Dolhman CH, Langer RS, Kohane DS. Polydopamine coatings enhance biointegration of a model polymeric implant. Soft Matter, 2011;7(18):8305-8312. Not indexed in Pubmed |
18. Pratt SJP, Lawlor MW, Shah SB, Lovering RM. An in vivo rodent model of contraction-induced injury in the quadriceps muscle. Injury, 2012;43(6):788-793. PMID 22001505 |
19. Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naier N, Gladman JT, Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, Beggs AH. Modeling the Human C205T Mutation in Murine Mtm1 Results in Exon 4 Skipping and a Less Severe Myotubular Myopathy Phenotype. Hum Molec Genet, 2012; 21(4):811-25. PMID 22068590 |
20. Hoare T, Sivakumaran D, Stefanescu C, Lawlor MW, Kohane DS. Nanogel scavengers for drugs: Local anesthetic uptake by thermoresponsive nanogels. Acta Biomater., 2012; 8(4):1450-8. PMID 22244983 |
21. Schichor I, Shomron N, Lawlor MW, Bae SA, Zoldan J, Langer R, Kohane DS. Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials. 2012; 33(13):3586-93. PMID 22341215 |
22. Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black K, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012; 4(140):140ra88. PMID 22745438 |
23. Lawlor MW, Alexander MS, Viola MG, Meng H, Joubert R, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Buj-Bello A, Kunkel LM, Beggs AH, Gussoni E. Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment. Am J Pathol. 2012; 181(3):961-8. PMID 22841819 |
24. Hoare T, Young S, Lawlor MW, Kohane DS. Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater. 2012; 8(10):3596-605. PMID 22732383 |
25. Amburgey K, Lawlor MW, Del Gaudio D, Cheng YW, Fitzpatrick C, Minor A, Li X, Aughton D, Das S, Beggs AH, Dowling JJ. Large duplication in MTM1 associated with myotubular myopathy. Neuromuscul Disord. 2013; 23(3):214-8. PMID 23273872 |
26. Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Gupta K, Boukedes SS, Owen CA, Beggs AH. Selenoprotein N deficiency in mouse is associated with abnormal lung development. FASEB J. 2013;27(4):1585-99. PMID 23325319 |
27. Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O’Callaghan M, Pierson CR, Buj-Bello A, Beggs AH. Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy Hum Mol Genet. 2013; 22(8):1525-38. PMID 23307925 |
28. de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJM, Lawlor MW, Beggs AH, Ottenheijm CAC, Granzier H. Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. J Med Genet 2013; 50(6):383-92. PMID 23572184 |
29. Ottenheijm CAC, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Steinen GJM, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H. Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy. Brain. 2013; 136(Pt 6):1718-31. PMID 23715096 |
30. Ceyhan O, Agrawal PB, Hidalgo C, Schmitz-Abe K, DeChene ET, Swanson LC, Soemedi R, Vasli N, Iannaccone ST, Shieh PB, Shur N, Dennison JM, Lawlor MW, Laporte J, Markianos K, Fairbrother WG, Granzier H, Beggs AH. Recessive truncating titin gene, TTN, mutations in patients with centronuclear myopathy. Neurology 2013; 81(14):1205-14. PMID 23975875 |
31. Wu MP, Doyle JR, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. GPR56 promotes myoblast fusion through SRE- and NFAT-mediated signaling but is not essential for muscle development in vivo. FEBS J. 2013; 280(23):6097-113. PMID 24102982 |
32. Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Stem Cell Research 2014; 12(2):467-80. PMID 24434629 |
33. Childers MK, Joubert R, Jamet T, Poulard K, Holder MN, Grange RW, Doering J, Lawlor MW, Moal C, Daniele N, Martin S, Riviere C, Poppante K, Soker T, Hammer C, Van Wittenberghe L, Guan X, Goddard M, Mitchell E, Barber J, Furth ME, Vignaud A, Masurier C, Mavilio F, Moullier P, Beggs, AH, Buj-Bello A. Gene therapy prolongs survival and restores muscle function in murine and canine models of X-linked myotubular myopathy. Science Translational Medicine 2014; 6(220):220ra10. PMID 24452262 |
34. Lawlor MW, Viola MG, Meng H, Edelstein RV, Liu F, Yan K, Luna EJ, Lerch-Gaggl A, Hoffmann RG, Pierson CR, Buj-Bello A, Lachey JL, Pearsall S, Yang L, Hillard CJ, Beggs AH. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1p.R69C mice. The American Journal of Pathology 2014; 184(6):1831-42. PMID 24726641 |
35. Meng H, Janssen PML, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, Gussoni E, Lawlor MW. Tissue triage and freezing for models of skeletal muscle disease. J Vis Exp 2014; Jul 15 (89). Doi: 10.3791/51586. PMID 25078247 |
36. Robin D, Wright EW, Zou Y, Cossette SA, Lawlor MW, Gussoni E. Isolation and immortalization of patient-derived cell lines from muscle biopsy for disease modeling. J Vis Exp 2015;(95):52307. Doi: 10.3791/52307. PMID 25651101 |
37. Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER. Whole thorax irradiation induces hypoxic respiratory failure, pleural effusions, and congestive heart failure. Journal of Radiation Research 2014; 56(2):248-60. PMID 25368342 |
38. Konersman CG, Bordini BJ, Scharer G, Lawlor MW, Zangwill S, Southern JF, Amos L, Geddes GC, Kliegman R, Collins MP. BAG3 myofibrillar myopathy presenting with cardiomyopathy. Neuromuscul Disord 2015; 25(5): 418-22. PMID 25728519 |
39. Hooijman PE, Beishuizen A, Witt CC, de Waard MC, Girbes AR, Spoelstra-de Man AM, Niessen HW, Manders E, van Hees HW, van den Brom CE, Silderhuis V, Lawlor MW, Labeit S, Stienen GJ, Hartemink KJ, Paul MA, Heunks LM, Ottenheijm CA. Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients. Am J Respir Crit Care Med 2015; 191(10):1126-38. PMID 25760684 |
40. Li F, Buck D, De Winter J, Kolb J, Meng H, Birch C, Slater R, Escobar YN, Smith JE, Yang L, Konhilas J, Lawlor MW, Ottenheijm C, Granzier HL. Nebulin deficiency in adult skeletal muscle of a novel mouse model (Neb cKO): Sarcomere defects and muscle atrophy as a mechanistic basis for muscle weakness. Human Molecular Genetics 2015;24(18):5219-33. PMID: 26123491 |
41. Dastgir J, Rutkowski A, Alvarez R, Cossette SA, Yan K, Hoffmann RG, Sewry C, Hayaski Y, Goebel HH, Bonnemann C, Lawlor MW. Common data elements for muscle biopsy reporting. Archives of Pathology and Laboratory Medicine 2015;140(1):51-65. PMID: 26132600 |
42. Goddard MA, Mack DL, Czerniecki SM, Kelly VE, Snyder JM, Grange RW, Lawlor MW, Smith BK, Beggs AH, Childers MK. Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy. Ann Transl Med 2015;3(18):262. PMID: 26605308 |
43. Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JL, Lawlor MW, Dimmock DP. Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. Free Radic Biol Med 2016;92:141-51. PMID: 26773591 |
44. Lawlor MW, Beggs AH, Buj-Bello A, Childers MK, Dowling JJ, James ES, Meng H, Moore SA, Prasad S, Schoser B, Sewry CA. Skeletal muscle pathology in X-linked myotubular myopathy: Review with cross species comparisons. J Neuropathol Exp Neurol 2016;75(2):102-10. PMID: 26823526 |
45. Zappie KJ, Garrison SR, Palygin O, Weyer AD, Barabas ME, Lawlor MW, Staruschenko A, Stucky CL. Mechanosensory and ATP release deficits following keratin 14-Cre-mediated TRPA1 deletion despite absence of TRPA1 in murine keratinocytes. PLoS One 2016 Mar 15;11(3):e0151602. PMID 26978657 |
46. Tinklenberg J, Meng H, Yang L, Liu F, Hoffmann RG, Dasgupta M, Allen KP, Beggs AH, Hardeman EC, Pearsall RS, Fitts RH, Lawlor MW. Treatment with ActRIIB-mFc produces myofiber growth and improves lifespan in the Acta1 H40Y murine model of nemaline myopathy. The American Journal of Pathology 2016;186(6)1568-81. PMID 27102768 |
47. Alexander MS, Rozkalne A, Colletta A, Spinazzola JM, Johnson S, Rahimov F, Meng H, Lawlor MW, Estrella E, Kunkel LM, Gussoni E. CD82 is a marker for prospective isolation of human muscle satellite cells and is linked to muscular dystrophies. Cell Stem Cell 2016;19(6):800-807. PMID 27641304 |
48. Dimmock DP, Lawlor MW. Presentation and diagnostic evaluation of mitochondrial disease. Pediatr Clin North Am 2017;64(1):161-171. PMID 27894442 |
49. Kutchukian C, Lo Scrudato M, Tourneur Y, Poulard K, Vignaud A, Berthier C, Allard B, Lawlor MW, Buj-Bello A, Jacquemond V. Phosphatidylinositol 3-kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice. Proc Natl Acad Sci USA 2016;113(50):14432-14437. PMID 27911767 |
50. Wu W, Chordia MD, Hart BP, Kumarasinghe ES, Ji MK, Bhargava A, Lawlor MW, Shin JY, Sera F, Homma S, Muchir A, Khire UR, Worman HJ. Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation. Bioorg Med Chem 2017;25(3):1004-1013. PMID 28011205 |
51. Mack DL, Poulard K, Goddard M, Snyder JM, Grange RW, Doering J, Latournerie V, Veron P, Buscara L, Le Bec C, Martin S, Mingozzi F, Mavilio F, Meng H, Yang L, Liu F, Beggs AH, Lawlor MW, Buj-Bello A, Childers MK. Gene replacement in dogs supports recombinant AAV for myotubular myopathy. Molecular Therapy 2017 Feb 22. S1525-0016(17)30056-4. doi: 10.1016/j.ymthe.2017.02.004. [Epub ahead of print]. PMID: 28237839 |
52. Elverman M, Goddard MA, Mack D, Snyder JM, Lawlor MW, Meng H, Beggs AH, Buj-Bello A, Poulard K, Marsh AP, Grange RW, Kelly VE, Childers MK. Long-term effects of systemic gene therapy in a canine model of myotubular myopathy. Muscle Nerve 2017 Mar 29. Doi” 10.1002/mus.25658 [Epub ahead of print]. PMID 28370029 |
53. Belle L, Zhou V, Stuhr KL, Beatka M, Siebers EM, Knight JM, Lawlor MW, Weaver C, Hashizume M, Hillard CJ, Drobyski WR. Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD. JCI Insight 2017 Jul 20; 2(14). pii: 93726. doi: 10.1172/jci.insight.93726. [Epub ahead of print]. PMID 28724796 |
54. van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wust RCI, Ottenheijm CA. Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically ill. Am J Respir Crit Care Med. 2017 Aug 8. doi: 10.1164/rccm.201703-0501OC. [Epub ahead of print]. PMID 28787181 |
Books, Chapters, and Reviews |
1. Shana ZA, Maki JS, Zanoni AE, Benes SJ, Mercier CJ, Lawlor MW. “The effect of high voltage electrostatic fields on zebra mussels” in Zebra mussels and aquatic nuisance species, ed FM D’Itri (Ann Arbor: Ann Arbor Press); 1997. 429-438 |
2. Lawlor MW. Rapid Review for the USMLE Step 2. Philadelphia: Mosby; 2007. 412 p. |
3. Lawlor MW, Beggs AH. “Thin filament proteins (nemaline and related myopathies)” in the ISN book on Muscle Disease: Pathology and Genetics. Hoboken: Wiley-Blackwell; 2013. p. 145-151. |
4. Lawlor MW, Pierson CR. “Congenital Myopathies” in Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease. 2014; In Press. |
5. Dowling JJ, Lawlor MW, Dirksen RT. Triadopathies: An emerging class of skeletal muscle diseases. Neurotherapeutics 2014;Aug 29 [Epub ahead of print]. PMID: 25168790 |
6. Amburgey K, Lawlor MW, Dowling JJ. “Chapter 43.8 Congenital Myopathies” in PG Textbook of Pediatrics. 2015. p. 2274-2278. |
