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CURRICULUM VITAE

Michele A. Battle PhD
Associate Professor
Department of Cell Biology, Neurobiology and Anatomy

OFFICE ADDRESS:
Basic Science Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
1992 - 1996 BS (summa cum laude), Biology and Philosophy, University of Scranton, Scranton, PA
1997 - 2002 PhD, Cell and Molecular Biology, Michigan State University, East Lansing, MI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
2003 - 2008 Postdoctoral Fellow; Mentor: Stephen Duncan; Research area: GI Developmental Biology, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
2008 Instructor, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI
2008 - 2014 Assistant Professor, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI
2014 - Present Member, Clinical and Translational Science Institute (CTSI) of Southeast Wisconsin, Milwaukee, WI
2014 - Present Associate Professor, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI
2015 - Present Member, Cancer Center, Cancer Biology Research Program, Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
1992 - 1996 Presidential Scholarship, University of Scranton, Scranton, PA
1994 - 1995 Rose Kelly Award for Outstanding Junior, University of Scranton, Scranton, PA
1997 - 1998 College of Natural Science Recruiting Fellowship, Michigan State University
1998 - 1999 Barnett Rosenberg Fellowship, Michigan State University
1999 Honorable Mention, Leventhal Scholar Award, Women in Cancer Research, American Association of Cancer Research
2002 Dissertation Completion Fellowship, Michigan State University
2004 - 2007 Ruth L. Kirschstein National Research Service Award (NRSA), NIH NIDDK
2007 Edward J. Lennon, MD Outstanding Woman Postdoctoral Researcher Award, Medical College of Wisconsin
2009 - 2010 Outstanding Medical Student Teacher, Medical College of Wisconsin
2009 Research Scholar Award, American Gastroenterological Association Research Foundation
2010 - 2011 Outstanding Medical Student Teacher, Medical College of Wisconsin
2015 Kavli Fellow, Kavli Foundation
2015 MCW Cancer Center Travel Award, Medical College of Wisconsin
2015 - 2019 Presidential Scholar Award, Medical College of Wisconsin
2015 - 2016 Outstanding Medical Student Teacher, Medical College of Wisconsin
2016 - 2017 Outstanding Graduate School Educator, Medical College of Wisconsin
2017 - 2018 Outstanding Graduate School Educator, Medical College of Wisconsin
2017 - 2018 Outstanding Graduate School Educator, Medical College of Wisconsin
2018 Women in Science Rising Pioneer Award, Medical College of Wisconsin
2019 - 2020 Outstanding Graduate School Educator, Medical College of Wisconsin
2019 - 2020 Outstanding Medical Student Teacher, Medical College of Wisconsin
2019 Best Poster Award, MCW Cancer Center 2019 Scientific Retreat

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
American Gastroenterological Association Research Foundation (Member)
Society for Developmental Biology (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
2021 - Present Associate Editor, American Journal of Physiology-Gastrointestinal and Liver Physiology
Editorial Board
2016 - Present Cellular and Molecular Gastroenterology and Hepatology
Journal Review
Journal of Clinical Investigation
Oncogene
Biology of Reproduction
Genes and Development
Experimental Cell Research
Nature Protocols
Physiological Genomics
Developmental Dynamics
Molecular and Cellular Biology
American Journal of Physiology-Gastrointestinal and Liver Physiology
BMC Genomics
Development
Developmental Biology
PLoS One
PLoS Genetics
BMC Developmental Biology
BBA-Gene Regulatory Mechanisms
Cellular and Molecular Gastroenterology and Hepatology
Scientific Reports
FASEB Journal
WIREs Developmental Biology
Nature
Biochemical Journal
Gut
Gastroenterology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2009 Reviewer, Digestive Diseases Center Grant Review Panel, Digestive Diseases Center, Medical College of Wisconsin
2017 Ad hoc reviewer, basic science panel, MCW Cancer Center, Medical College of Wisconsin
2018 Reviewer, Digestive Disease Center Grant Review Panel, Digestive Disease Center, Medical College of Wisconsin

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2010 Session Co-Chair, Development and Differentiation in the Gastrointestinal Tract, American Gastroenterological Association Sponsored Research Forum, Digestive Disease Week, New Orleans, LA
2011 Session Co-Chair, Development and Differentiation in the Gastrointestinal Tract, American Gastroenterological Association Sponsored Research Forum, Digestive Disease Week, Chicago, IL
2012 Reviewer, ZDK1 GRB8(O1) Program Project on Alpha-1 Deficiency, NIH NIDDK
2013 Reviewer, ZDK1 GRB8(M2) Program Project on Intestinal Transport, NIH NIDDK
2014 Reviewer, ZDK GRB8(M3), Intestinal Stem Cell U01, NIH NIDDK
2017 Session Co-Chair, In Vivo (Non-Human) Models of Gastrointestinal Disorders, American Gastroenterological Association Sponsored Research Forum, Digestive Diseases Week, Chicago, IL
2017 Reviewer, ZRG1 DKUS-N (10) Small Business: Digestive Sciences Review Panel, NIH CSR
2017 Reviewer, ZDK1 GRB-2(J3) AT Deficiency P01, NIH, NIDDK
2017 Reviewer, Digestive Disease Center, Harvard University
06/2018 - 05/2021 Member, Research Fellowship Awards Committee, Crohn's and Colitis Foundation
2018 Reviewer, 2018/05 ZDK1 GRB-6 (M1) Esophageal Related P01s, NIH NIDDK
2018 Reviewer, 2018/05 DDK-C Digestive Disease and Nutrition Subcommittee C, NIH, NIDDK
2018 Reviewer, 2019/01 DDK-C Digestive Disease and Nutrition Subcommittee C, NIH NIDDK
2019 Reviewer, 2019/10 ZRG1-DKUS-T-90 Topics in Gastroenterology, NIH CSR
2019 Reviewer, Pilot and Feasibility Program, DIACOMP, NIDDK
2019 - 2021 Co-Organizer, FASEB Summer Research Conference, Gastrointestinal Tract XIX: Making and Breaking a Gut, Virtual Conference
2019 - 2020 Organizing Committee, AGA James Freston Conference: Gastrointestinal Organoids and Engineered Organoid Systems
2019 - 2022 Co-Organizer, FASEB Summer Research Conference, Gastrointestinal Tract XIX: Making and Breaking a Gut, Steamboat Springs, CO
2019 Reviewer, Merit Review Subcommittee For Oncology-C, Dept of Veterans Affairs
2019 Reviewer, 2019/05 ZRG1-DKUS-T-90 Topics in Gastroenterology, NIH, CSR
2020 Reviewer, 2020/10 ZRG DKUS-A (90), Topics in Gastroenterology, NIH, CSR
2020 Reviewer, 2020/05 ZRG DKUS-A (90) Special Topics in Gastroenterology, NIH CSR
2020 Reviewer, SEP ZDK-GRB-S (J3)AR19-319: NIDDK CENTRAL REPOSITORIES NON-RENEWABLE SAMPLE ACCESS (X0)-DIGESTIVE AND LIVER DISEASES, NIH CSR
2020 Reviewer, National Science Foundation (NSF)
2021 - Present Vice-Chair, Cellular and Molecular Gastroenterology Section, American Gastroenterological Association Institute Council
2021 Reviewer,, Fellowships: Cell Biology, Developmental Biology, and Bioengineering F05-D21, NIH CSR
2021 Reviewer, NCI P01 Grant Review, NIH, NCI
2021 Reviewer, ZRG1 Digestive and Nutrient Physiology and Diseases (DNPD), NIH CSR

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
R01 DK111822 GATA4 in development of a normal squamocolumnar junction and Barrett's esophagus (NCE)
Source:
NIH NIDDK
Role:
PI
PI:
Michele Battle
Dates:
07/01/2017 - 06/30/2022
 
Title:
Deciphering GATA4 function in gastric parietal cells and its relationship to gastric disease
Source:
MCW Office of Research Competitive Needs Opportunity
Role:
PI
PI:
Michele Battle
Dates:
2021 - 2022
 
Non-Peer Review
Title:
Women in Science Rising Pioneer Award
Source:
MCW
Role:
PI
PI:
Michele Battle
Dates:
2018 - Present
 
Prior
Peer Review
Title:
F32 DK067808 The Role of HNF4 in Gastrointestinal Development
Source:
NIDDK
Role:
PI
PI:
Michele Battle
Dates:
2004 - 2007
 
Title:
Determining the Role that GATAs play in Intestinal Development and Function
Source:
American Gastroenterological Association Research Foundation
Role:
PI
PI:
Michele Battle
Dates:
2009 - 2011
 
Title:
R01 DK087873 Determining Mechanisms Regulating Functional Regionalization of the Intestine
Source:
NIH NIDDK
Role:
PI
PI:
Michele Battle
Dates:
2010 - 2016
 
Title:
Transcriptional Control of Early Human Intestinal Development by GATA factors
Source:
Research Affairs Committee, Medical College of Wisconsin
Role:
PI
PI:
Michele Battle
Dates:
2011 - 2013
 
Title:
Defining the role of HNF4 family transcription factors in gastrointestinal development
Source:
Digestive Disease Center, Medical College of Wisconsin
Role:
PI
PI:
Michele Battle
Dates:
2013 - 2014
 
Title:
Cellular mechanisms driving visceral pain during colitis
Source:
Advancing a Healthier Wisconsin
Role:
Co-PI
PI:
Cheryl Stucky and Michele Battle
Dates:
01/01/2014 - 12/31/2016
 
Title:
Administrative Supplement to R01 DK087873
Source:
NIH NIDDK
Role:
PI
PI:
Michele Battle
Dates:
07/01/2015 - 06/30/2016
 
Title:
R56 DK087873 Determining Mechanisms Regulating Functional Regionalization of the Intestine
Source:
NIH NIDDK
Role:
PI
PI:
Michele Battle
Dates:
09/15/2016 - 08/31/2017
 
Title:
Microbial approaches for the treatment of multi-drug resistant enterococci
Source:
AHW-Research and Education Program
Role:
Co-Investigator
PI:
Nita Salzman
Dates:
2016 - 2017
 
Title:
R01-GATA4 in development of a normal squamocolumnar junction and Barrett's esophagus
Source:
MCW Cancer Center
Role:
PI
PI:
Michele Battle
Dates:
01/01/2017 - 12/30/2017
 
Title:
Epithelial and neuronal interactions in colitis: a role for sensory neurons in protecting the colon epithelium
Source:
DOD, Peer Reviewed Medical Discovery Award
Role:
PI
PI:
Michele Battle
Dates:
05/15/2017 - 11/14/2018
 
Title:
Role of astrocyte-produced miR146a in SMA pathology
Source:
Cure SMA
Role:
Co-Investigator
PI:
Allison Ebert
Dates:
04/01/2018 - 03/31/2020
 
Title:
R21 NS102911-01A1 Mechanistic link between GATA factors, SMN, and astrocyte senescence in SMA pathology (NCE)
Source:
NIH
Role:
Co-Investigator
PI:
Allison Ebert
Dates:
06/15/2018 - 05/31/2021
 
Title:
The Role of GATA4 During Gastric Epithelial Cell Homeostasis and Metaplasia
Source:
American Cancer Society Postdoctoral Fellowship
Role:
Mentor/Sponsor
PI:
Ann DeLaForest
Dates:
07/01/2019 - 06/30/2021
 
Title:
3R01DK1118222-03S1 GATA4 in development of a normal squamocolumnar junction and Barrett's esophagus
Source:
NIH NIDDK
Role:
PI
PI:
Michele Battle
Dates:
07/01/2019 - 06/30/2021
 
Title:
The role of GATA4 during gastric epithelial cell homeostasis and metaplasia
Source:
MCW Digestive Diseases Center (MCW DDC)
Role:
PI
PI:
Michele Battle
Dates:
2019 - 2020
 
Title:
RAPID: How vertebrate end-lysosomal Ca2+ channels control coronaviral tropism
Source:
National Science Foundation
Role:
PI (MPI)
PI:
Marchant, Battle, Hudson
Dates:
06/2020 - 05/2021
 
Title:
Developing a preclinical model to screen novel agents to treat esopahgeal cancer
Source:
MCW Cancer Center
Role:
PI
PI:
Michele A. Battle
Dates:
2020
 
Non-Peer Review
Title:
MCW Presidential Scholar Award
Source:
MCW
Role:
PI
PI:
Michele Battle
Dates:
08/01/2015 - 07/31/2018
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
HNF4a orchestrates epithelial morphogenesis in the developing mouse liver, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 11/2006
Transcriptional regulation of intestinal development and function by GATA factors, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 01/2009
Transcriptional regulation of intestinal development and function, Inflammation and Cancer Cell Biology Research Group, Medical College of Wisconsin, Milwaukee, WI, 04/2009
Determining the Mechanisms Regulating Functional Regionalization of the Small Intestinal Epithelium, Summer Program for Undergraduate Research (SPUR), Medical College of Wisconsin, Milwaukee, WI, 07/2010
Gastrointestinal Development and Function, Apprentice in Medicine (AIM) Program, Medical College of Wisconsin, Milwaukee, WI, 2010 - 2011
Gastrointestinal Development and Function, Milwaukee Academy of Science, Milwaukee, WI, 06/2011
Stem Cells: Revolutionizing Patient Care, Medical College of Wisconsin Women in Science Seminar, Milwaukee, WI, 06/2012
Leading a research laboratory, New Leader Orientation, 4 presentations, Medical College of Wisconsin, 2012 - 2013
Regulation of intestinal development and function by GATA factors, Pediatric Surgery Multidisciplinary Research Conference, Medical College of Wisconsin, Milwaukee, WI, 05/2013
Determining the function of GATA factors in the epithelium of the gastrointestinal tract, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 03/25/2015
Novel roles of GATA4 in the GI tract: Implications for Barrett's esophagus, Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 10/2015
Leading a research laboratory, Office of Research, Medical College of Wisconsin, Milwaukee, WI, 05/05/2016
GATA4: Roles in Development and Function of GI Organs, Summer Program for Undergraduate Research (SPUR), Medical College of Wisconsin, Milwaukee, WI, 07/2016
Novel roles of GATA4 in the GI tract: Implications for Barrett's esophagus, Cell Biology, Neurobiology, and Anatomy Department, Medical College of Wisconsin, Milwaukee, WI, 10/05/2016
Using 3D organoid culture to study gastrointestinal development and disease, MCW MSTP Retreat 2016, Student Choice Seminar, Sheboygan, WI, 11/11/2016
A novel role for GATA4 in the GI tract: implications for Barrett's esophagus, Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 09/2017
Novel Roles for GATA Factors in Gastrointestinal Homeostasis and Disease, Hematology and Oncology Fellows Retreat, Medical College of Wisconsin, 09/11/2020
Novel Roles for GATA Factors in Gastrointestinal Tract Homeostasis and Disease, Medical College of Wisconsin Cancer Center, Milwaukee, WI, 2021
 
National
Transcriptional regulation of intestinal development and function, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 11/2009
Transcriptional regulation of intestinal development and function by GATA factors, Endoderm Club Seminar, Cincinnati Children’s Hospital, Cincinnati, OH, 08/2010
GATA4 and GATA6 are required for intestinal development (poster), NIH NIDDK New PIs Workshop, Bethesda, MD, 12/2012
Regulation of intestinal development and function by GATA factors, Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 01/2013
U.S. Kavli Frontiers of Science Symposium, National Academy of Sciences, Irvine, CA, 11/2015
A novel role for GATA4 in the GI tract: Implications for Barrett's esophagus, Baylor, Scott, and White Research Institute, Dallas, TX, 10/2017
A novel role for GATA4 in the GI tract: Implications for Barrett's esophagus, Digestive Disease Center, Baylor College of Medicine, Houston, TX, 10/2017
GATA4 and development of the squamocolumnar junction: Implications for Barrett's esophagus, Columbia University Medical Center, New York, NY, 03/2019
GATA4 and development of the squamocolumnar junction: Implications for Barrett's esophagus, University of Michigan, Ann Arbor, MI, 03/2019
Novel Roles for GATA Factors in Gastrointestinal Disease and Homeostasis, Vanderbilt University Medical Center, Digestive Diseases Research Center, Nashville, TN, 09/2019
Novel Roles for GATA Factors in Gastrointestinal Tract Homeostasis and Disease, University of Pennsylvania, Perelman School of Medicine, Digestive Diseases Research Center, Philadelphia, PA, 11/2019
Novel Roles for GATA Factors in Gastrointestinal Tract Homeostasis and Disease, University of Wisconsin Madison, Department of Nutritional Sciences, Madison, WI, 12/2019
Novel Roles for GATA Factors in Gastrointestinal Tract Homeostasis and Disease, The Fels Institute for Cancer Research and Molecular Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 01/2020
Novel Roles for GATA Factors in Gastrointestinal Tract Homeostasis and Disease, Medical University of South Carolina, Charleston, SC, 02/2020
Novel Roles for GATA Factors in Gastrointestinal Homeostasis and Disease, Cornell University, Ithaca, New York, 12/2020
 
International
HNF4a orchestrates expression of cell adhesion proteins to control formation of the hepatic epithelium, Institute of Laboratory Medicine and Biochemistry, Charite Campus Virchow Hospital, Medical School of Humboldt University, Berlin, Germany, 07/2005
The role of CGRP signaling in colon epithelial cells during colitis, CGRP Conference 2018, Santa Fe, NM, 02/2018
Transcription Factors Driving Metaplasia in Barrett's Esophagus, Cellular Plasticity, Metaplasia, and Tissue Repair Symposium, Digestive Diseases Week, Washington, DC, 06/2018
Regional Differentiation of the Intestine, Developmental Biology of the Gastrointestinal Tract Research Symposium, Digestive Diseases Week, Washington, DC, 06/2018
Transcriptional Regulation of Barrett's Metaplasia, Keystone Symposia Conference, Cellular Plasticity: Reprogramming, Regeneration and Metaplasia, Keystone, CO, 01/2019
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
Novel roles for GATA4 in defining the squamocolumnar junction: Implications for Barrett's esophagus, MCW Cancer Center 2019 Scientific Retreat, Milwaukee, WI (winner best poster), 04/2019
 
International
HNF4 is required for expression of proteins involved in cell adhesion and junction formation, FASEB Science Research Conference: Mechanisms of Liver Growth, Development, and Disease, Snowmass, CO, 08/2004
HNF4a orchestrates expression of proteins required for cell adhesion and junction formation, Gordon Research Conference: Cell Contact and Adhesion, Proctor Academy, Andover, New Hampshire, 06/2005
GATA4 is required for proper function of the small intestine (oral presentation), EMBO workshop: The role and control of GATA factors in tissue development and disease, Capri, Italy, 04/2007
GATA4 is required for lipid absorption by the small intestine epithelium (oral presentation), FASEB Science Research Conference: Gastrointestinal Tract XII: The Molecular and Integrative Basis for GI Development, Homeostasis and Disease,, Snowmass, CO, 08/2007
E-cadherin is essential for intestinal epithelial morphogenesis in the mouse (oral presentation, session co-chair), AGA Sponsored Research Forum, Development and Differentiation in the Gastrointestinal Tract, Digestive Diseases Week, New Orleans, LA, 05/2010
GATA4 and GATA6 are Required for Proper Intestinal Development, Society for Developmental Biology Annual Meeting, Chicago, IL, 07/2011
GATA4 and GATA6 are Required for Proper Intestinal Development, FASEB Science Research Conference: Gastrointestinal Tract XIV: Stem Cells, Adaptation, Inflammation, and Cancer, Steamboat Springs, CO, 08/2011
GATA factors regulate intestinal epithelial morphogenesis and cytodifferentiation during development, FASEB Science Research Conference: Gastrointestinal Tract XV: Epithelia Microbes, Inflammation, and Cancer, Steamboat Springs, CO, 08/2013
GATA4 suppresses ileal gene expression to confer jejunal character in the intestinal epithelium, FASEB Science Research Conference: Gastrointestinal Tract XV: Epithelia Microbes, Inflammation, and Cancer, Steamboat Springs, CO, 08/2013
GATA4 is required for proper gastrointestinal development, FASEB Science Research Conference: Gastrointestinal Tract XV: Epithelia Microbes, Inflammation, and Cancer, Steamboat Springs, CO, 08/2013
Novel roles for GATA4 in defining the squamocolumnar junction in the GI tract: Implications for Barrett's esophagus, FASEB Science Research Conference: Gastrointestinal Tract XVI: GI homeostasis, the microbiome and the barrier, development and disease, Steamboat Springs, CO, 08/2015
Novel Roles for GATA4 in Defining the Squamocolumnar Junction in the GI Tract: Implications for Barrett's Esophagus (oral presentation), AGA 2016 James W. Freston Conference, Chicago, IL, 08/2016
GATA4 regulates development of the squamocolumnar junction in the GI tract: Implications for Barrett's esophagus (oral presentation), AGA Sponsored Research Forum, Cellular and Molecular Gastroenterology Distinguished Abstract Plenary Session, Digestive Diseases Week, Chicago, IL, 05/2017
GATA4 is required for budding morphogenesis of human posterior foregut endoderm in vitro, GI Stem Cells and Tissue Engineering Poster Session, Digestive Diseases Week, Washington, DC, 06/2018
GATA4 inhibits expression of p63 and its downstream targets in stratified squamous cells, Cellular Plasticity in Regeneration and Metaplasia Research Forum, Digestive Diseases Week, Washington, DC, 06/2018
Novel Roles for GATA4 in Defining the Squamocolumnar Junction in the GI Tract: Implications for Barrett's Esophagus, FASEB Science Research Conference: Gastrointestinal Tract XXVIII, Steamboat Springs, CO, 08/2019
Repression of Stratified Squamous Cell Gene Expression and Induction of adenosquamous lesions in GATA4 expressing esophageal cells, FASEB Science Research Conference: Gastrointestinal Tract XXVIII, Steamboat Springs, CO, 2019
GATA4 is required for gastric epithelial cell homeostasis, Digestive Diseases Week, Cancelled due to COVID-19, 2020
GATA4 suppresses squamous cell identity and promote columnar gene expression in patient-derived esophageal epithelial cells, FASEB Science Research Conference: Gastrointestinal Tract XIX- Making and Breaking a Gut, Virtual, 2021
Parietal Cell Function is Reliant upon GATA4, Digestive Diseases Week, Virtual, 2021
GATA4 suppresses squamous cell identity and promote columnar gene expression in patient-derived esophageal epithelial cells, Digestive Diseases Week, Virtual, 2021
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2010 - Present Member, Graduate Studies Council, Medical College of Wisconsin
2010 - 2013 Department Representative (alternate), Faculty Council, Medical College of Wisconsin
2010 - 2011 Member, Graduate Studies Council Student Admission and Welfare Committee, Medical College of Wisconsin
2010 - 2011 Member, Interdisciplinary Program Recruitment Committee, Medical College of Wisconsin
2011 - Present Member, Medical Scientist Training Program Admissions, Medical College of Wisconsin
2011 - 2013 Member, Environmental Sustainability Committee, Medical College of Wisconsin
2011 - 2013 Chair, Graduate Studies Council Student Admission and Welfare Committee, Medical College of Wisconsin
2011 - 2019 Chair, Interdisciplinary Program Recruitment Committee, Medical College of Wisconsin
2015 - Present Member, Cell and Developmental Biology Program Advisory Committee, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin
2015 - 2017 Member, Search Committee for the Chair of Dept. of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin
2016 - Present Member, Biomedical Research Advisory Committee, Medical College of Wisconsin
2018 - Present Member, IDP Course Directors Group, Medical College of Wisconsin
2019 - Present Member, M1-M2 Basic Science Workgroup, Medical College of Wisconsin
2019 - Present Member, M1-M2 Course Directors and Coordinators Committee, Medical College of Wisconsin
 
Hospital
2021 - Present Member, Search Committee, Section Chief,Pediatric Gastroenterology, Pediatrics, Children's Hospital of Wisconsin/ Medical College of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
2009 - 2011 Cell and Tissue Biology-Cell Junctions and Epithelia lecture
2009 - 2011 Cell and Tissue Biology-Digestive 1 (oral glands, esophagus, stomach) Virtual Microscope Lab
2009 - 2011 Cell and Tissue Biology-Digestive 3 (Liver, Gall Bladder, Pancreas) Virtual Microscope Lab
2009 - 2011 Cell and Tissue Biology-Cell Junctions and Epithelia Virtual Microscope Lab
2009 - 2012 Cell and Tissue Biology-Upper GI lecture
2009 - 2011 Cell and Tissue Biology-Digestive 2 (Lower GI: Small and Large Intestine) Virtual Microscope Lab
2010 Team-based learning medical school curriculum development: designed and facilitated one session on epithelial biology
2011 Developmental Biology--GI system development (intestine, liver, and pancreas)
2011 Team-based learning medical school curriculum development: designed and facilitated 5 sessions on GI tract development and structure
2012 - Present Molecules to Cells - Cell Junctions and Epithelia Virtual Microscope Lab
2012 - Present Molecules to Cells - Cell Junctions and Epithelia lecture
2014 - Present Gastrointestinal and Nutritional Pathophysiology, Normal Structure and Function of the Oral Cavity and Upper GI Tract lecture
2014 - Present Gastrointestinal and Nutritional Pathophysiology, Developmental and Congenital Abnormalities of the GI tract (contributed study guide)
2014 - Present Gastrointestinal and Nutritional Pathophysiology, Normal Structure and Function of the Oral Cavity and Upper GI Tract, Virtual Microscope Lab
2019 - Present Co-Director, Gastrointestinal and Nutrition Pathophysiology Unit
 
Graduate Student Education
2008 Developmental and Stem Cell Biology - 2 lectures
2010 Developmental and Stem Cell Biology - 2 lectures
2011 - 2014 Techniques in Molecular and Cellular Biology - 1 lecture
2011 Analysis Journal Club - 1 lecture
2011 - Present Co-Director, Integrated Analyses of the Contribution of Developmental Biology and Stem Cell Biology to the Study of Childhood Disease and Development
2011 - 2013 Molecular Biology of the Cell - 1 lecture
2012 Developmental and Stem Cell Biology - 7 sessions
2013 Advanced Cell Biology - 4 sessions
2014 Developmental and Stem Cell Biology - 3 sessions
2015 Advanced Cell Biology - 2 sessions
2016 Developmental and Stem Cell Biology -- 2 sessions and Course Director
2016 - Present Stem Cell and Development Biology Journal Club, Course Director
2017 Advanced Cell Biology -- 2 sessions
2018 Developmental and Stem Cell Biology--8 sessions and Course Director
2018 Responsible Conduct in Research, Small Group Facilitator
2021 Developmental and Stem Cell Biology- Course Director and 5 sessions
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Kevin Wojta, Medical College of Wisconsin, 2009 SPUR student researcher
Ann-Marie Lee, Medical College of Wisconsin, 2011 SPUR student researcher
Alexandria Sweetman, Medical College of Wisconsin, 10/2013 - 12/2013 PURE internship program
Logan Kludt, Medical College of Wisconsin, 2016 SPUR
Hilary Marrero-Garcia, Medical College of Wisconsin, 2017 SPUR
Emily Siniscalco, Medical College of Wisconsin, 2018 SPUR
Gabriella Metten, Medical College of Wisconsin, 2019 - 2020 PURE Student
 
Medical Students
Benjamin Bondow, Medical College of Wisconsin, 2012 Preceptor, Medical Student Summer Research Program
 
Graduate Students
PhD Committees
Fallon Noto, Medical College of Wisconsin, 2009 - 2012
Max Cayo, Medical College of Wisconsin, 2010 - 2015
Ann Delaforest, Medical College of Wisconsin, 2010 - 2013
Kirk Twaroski, Medical College of Wisconsin, 2011 - 2015
Joel Meisfield, Medical College of Wisconsin, 2011 - 2014
Amanda Urick, Medical College of Wisconsin, 2012 - 2017
Andy Weyer, Medical College of Wisconsin, 2013 - 2015
Kristen Westdorp, Medical College of Wisconsin, 2013 - 2017
Karen Hansen, Medical College of Wisconsin, 2013 - 2017
Rajrupa Chakraborty, Medical College of Wisconsin, 2013 - 2018
Joshua Nord, Medical College of Wisconsin, 2015 - 2019
Megan Determan, Medical College of Wisconsin, 2015
Francie Moehring, Medical College of Wisconsin, 2016 - 2018
Orlando DeLeon, Medical College of Wisconsin, 2017 - 2019
Theresa Bluemn, Medical College of Wisconsin, 2017 - 2021
Rebekah Mokry, Medical College of Wisconsin, 2018 - 2021
Puja Agrawal, Medical College of Wisconsin, 2018 - 2021
Savannah Neu, Medical College of Wisconsin, 2019 - Present
Ugochukwu Ihenacho, Medical College of Wisconsin, 2019 - Present
Kaelin Akins, Medical College of Wisconsin, 2020 - Present
Alex Mikesell, Medical College of Wisconsin, 2021 - Present
Priscilla Kyi, Medical College of Wisconsin, 2021 - Present
Matthew Mortensen, Medical College of Wisconsin
PhD Students Advised
Emily Walker, Medical College of Wisconsin, 2010 - 2014 Current position: Research Investigator, University of Michigan, Ann Arbor, MI
Cayla Thompson, Medical College of Wisconsin, 2011 - 2017 Current Position, Senior Scientist, Fujifilm Cellular Dynamics, Inc., Madison, WI
Bridget Kohlnhofer, Medical College of Wisconsin, 2011 - 2016 Current position: Scientist II, Takada GI Drug Discovery Unit, San Diego, CA
Talia Frolkis, Medical College of Wisconsin, 2019 - 2020
Olivia Franklin, Medical College of Wisconsin, 2020 - Present
 
Postdoctoral Students
Roman Stavniichuk, Medical College of Wisconsin, 2016 - 2018, Current Position: Associate Research Scientist, Gene and Cell Therapy, PPD, Madison, WI
Ann Delaforest, Medical College of Wisconsin, 2017 - 2021, Current Position, Senior Scientist, Celcuity, Minneapolis, MN
 
Faculty
John Chan, Medical College of Wisconsin, 2018 - 2020 Faculty Mentoring Committee, Chair
Ken Tanguichi, Medical College of Wisconsin, 2020 - Present Faculty Mentoring Committee, Chair
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Afiya Quryshi, University School of Milwaukee, Milwaukee, WI, 2017 - Present Research mentor
Stephen Merrills, Hope Christian High School, Milwaukee, WI, 2018 Research mentor
 
Graduate Students
PhD Committees
Ran Jing, Medical University of South Carolina, 2014 - 2018
Fatima Aboulalazm, Medical College of Wisconsi, 2021 - Present
 

COMMUNITY SERVICE ACTIVITIES:
2011 Mentor, Connecting Researchers, Educators, and Students (CREST) Team from Mt. Mary College
2011 Lecture, Gastrointestinal Development and Function, Milwaukee Academy of Science, Milwaukee, WI
2012 - 2015 Board Member, Friends of the Medical College of Wisconsin
2012 Lecture, Stem Cells: Revolutionizing Patient Care, Medical College of Wisconsin Women in Science Seminar, Milwaukee, WI
2018 MCW Women in Science Rising Pioneer Awards Luncheon, Investigating Development of The Gastrointestinal Tract to Understand Mechanisms of Human Disease
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Battle MA, Maher VM, McCormick JJ. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. Biochemistry. 2003 Jun 24;42(24):7270-82.
2. Watt AJ, Battle MA, Li J, Duncan SA. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12573-8. PMCID: PMC515098
3. Rufibach LE, Duncan SA, Battle M, Deeb SS. Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. J Lipid Res. 2006 Jul;47(7):1463-77.
4. Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006 Apr;130(4):1207-20. PMCID: PMC3581272
5. Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8419-24. PMCID: PMC1482507
6. Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA. Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008 May 15;317(2):614-9. PMCID: PMC2423416
7. Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct;48(4):1242-50. PMCID: PMC2717709
8. Battle MA, Bondow BJ, Iverson MA, Adams SJ, Jandacek RJ, Tso P, Duncan SA. GATA4 is essential for jejunal function in mice. Gastroenterology. 2008 Nov;135(5):1676-1686.e1. PMCID: PMC2844802
9. Sun K, Battle MA, Misra RP, Duncan SA. Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. Hepatology. 2009 May;49(5):1645-54. PMCID: PMC2810404
10. Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, North PE, Dalton S, Duncan SA. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology. 2010 Jan;51(1):297-305. PMCID: PMC2946078
11. Patankar JV, Chandak PG, Obrowsky S, Pfeifer T, Diwoky C, Uellen A, Sattler W, Stollberger R, Hoefler G, Heinemann A, Battle M, Duncan S, Kratky D, Levak-Frank S. Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E478-88. PMCID: PMC3163292
12. Chamouton J, Hansmannel F, Bonzo JA, Clémencet MC, Chevillard G, Battle M, Martin P, Pineau T, Duncan S, Gonzalez FJ, Latruffe N, Mandard S, Nicolas-Francès V. The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver. PPAR Res. 2010;2010:352957. PMCID: PMC3061263
13. DeLaForest A, Nagaoka M, Si-Tayeb K, Noto FK, Konopka G, Battle MA, Duncan SA. HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. Development. 2011 Oct;138(19):4143-53. PMCID: PMC3171218
14. Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med. 2011 Nov 20;17(12):1585-93. PMCID: PMC3902046
15. Patankar JV, Obrowsky S, Doddapattar P, Hoefler G, Battle M, Levak-Frank S, Kratky D. Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis. J Hepatol. 2012 Nov;57(5):1061-8. PMCID: PMC3477492
16. Bondow BJ, Faber ML, Wojta KJ, Walker EM, Battle MA. E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012 Nov 01;371(1):1-12. PMCID: PMC3455111
17. Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012 Oct;122(10):3516-28. PMCID: PMC3461916
18. Walker EM, Thompson CA, Battle MA. GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. Dev Biol. 2014 Aug 15;392(2):283-94. PMCID: PMC4149467
19. Walker EM, Thompson CA, Kohlnhofer BM, Faber ML, Battle MA. Characterization of the developing small intestine in the absence of either GATA4 or GATA6. BMC Res Notes. 2014 Dec 11;7:902. PMCID: PMC4307969
20. Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ. Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. J Neurosci. 2015 May 13;35(19):7503-8. PMCID: PMC4429154
21. Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC. Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function. J Biol Chem. 2016 Mar 18;291(12):6146-57. PMCID: PMC4813565
22. Kohlnhofer BM, Thompson CA, Walker EM, Battle MA GATA4 regulates epithelial cell proliferation to control intestinal growth and development in mice. Cell Mol Gastroenterol Hepatol. 2016 Mar;2(2):189-209 PMCID: PMC4823006 Featured as Journal Cover
23. Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR. A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. Stem Cell Reports. 2016 11 08;7(5):826-839. PMCID: PMC5106483
24. Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM. Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. Stem Cell Reports. 2017 03 14;8(3):491-499. PMCID: PMC5355643
25. Thompson CA, Wojta K, Pulakanti K, Rao S, Dawson P, Battle MA. GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):422-446. PMCID: PMC5404030
26. Fields B, DeLaForest A, Zogg M, May J, Hagen C, Komnick K, Wieser J, Lundberg A, Weiler H, Battle MA, Carlson KS. The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis. Sci Rep. 2019 12 17;9(1):19303. PMCID: PMC6917708
27. DeLaForest A, Quryshi AF, Frolkis TS, Franklin OD, Battle MA. GATA4 Is Required for Budding Morphogenesis of Posterior Foregut Endoderm in a Model of Human Stomach Development. Front Med (Lausanne). 2020;7:44. PMCID: PMC7042400
28. McCormick CA, Samuels TL, Battle MA, Frolkis T, Blumin JH, Bock JM, Wells C, Yan K, Altman KW, Johnston N. H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients. Laryngoscope. 2021 01;131(1):130-135.
29. Stavniichuk R, DeLaForest A, Thompson CA, Miller J, Souza RF, Battle MA. GATA4 blocks squamous epithelial cell gene expression in human esophageal squamous cells. Sci Rep. 2021 Feb 05;11(1):3206. PMCID: PMC7864948
30. DeLaForest A, Kohlnhofer BM, Franklin OD, Stavniichuk R, Thompson CA, Pulakanti K, Rao S, Battle MA. GATA4 Controls Epithelial Morphogenesis in the Developing Stomach to Promote Establishment of Glandular Columnar Epithelium. Cell Mol Gastroenterol Hepatol. 2021 Jun 07;12(4):1391-1413. PMCID: PMC8479485
31. R. Ramadan, SM. van Neerven, VM. Wouters, T. Martins Garcia, V. Muncan, OD. Franklin, M. Battle, KS. Carlson, J. Leach, OJ. Sansom, L. Vermeulen, JP. Medema, DJ. Huels. The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult gut bioRxiv pre-print. bioRxiv 2021.04.14.439776; doi: https://doi.org/10.1101/2021.04.14.439776.
 
Books, Chapters, and Reviews
1. Thompson, CA, & Battle, MA: Basic Science of Small Intestinal Development. In Translational Gastroenterology: Organogenesis to Disease. D.L. Gumucio, L.C. Samuelson, & J.R. Spence (Eds.) Hoboken, NJ: Wiley Blackwell Publishers; 2014:85-97.
2. Thompson CA, DeLaForest A, Battle MA. Patterning the gastrointestinal epithelium to confer regional-specific functions. Dev Biol. 2018 03 15;435(2):97-108. PMCID: PMC6615902