CURRICULUM VITAE
Michelle Brenner DO, MS
Michelle Brenner DO, MS
Instructor
Department of Pediatrics
Division of Pediatrics Hematology Oncology Blood and Marrow Transplant
Department of Pediatrics
Division of Pediatrics Hematology Oncology Blood and Marrow Transplant
OFFICE ADDRESS: |
999 N. 92nd Street |
Milwaukee, WI 53226 |
EDUCATION: |
05/2010 Bachelor of Natural Science. Major: Biochemistry. Second Major: Spanish, University of Wisconsin-Madison, Madison, WI |
05/2014 Master of Science. Major: Clinical and Translational Science, Medical College of Wisconsin, Milwaukee, WI |
05/2019 Doctor of Osteopathic Medicine, Des Moines University, Des Moines, IA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
06/2022 Pediatric Resident, Pediatrics, Pediatrics Residency Program, University of Wisconsin-Madison, Madison, WI |
06/2025 Pediatric Fellow, Pediatrics, Pediatric Hematology/Oncology/BMT Fellowship, Medical College of Wisconsin / Children's Wisconsin, Milwaukee, WI |
FACULTY APPOINTMENTS: |
07/01/2025 - Present Instructor, Pediatrics, Hematology, Oncology, BMT, Medical College of Wisconsin |
HOSPITAL STAFF PRIVILEGES: |
08/04/2025 - Present Instructor, Children’s Wisconsin, 9000 W. Wisconsin Ave., Milwaukee, WI, WI 53226 |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
Pediatrics | 10/13/2022 | 12/16/2027 |
Licensure | Number | Issue Date | Expiration |
Licensure Wisconsin | 74725 - 21 | 03/02/2021 | 10/31/2025 |
AWARDS AND HONORS: |
02/2016 Sigma Sigma Phi (SSP) member , National Osteopathic Honor Society |
12/2016 Most Outstanding Graduate Poster Presentation: Biomedical Science , Des Moines University Research Symposium |
11/2017 Student DO of the Year Nominee for Des Moines University , Des Moines University |
06/2018 Gold Humanism Honor Society, Des Moines University |
02/2022 American Academy of Pediatrics (AAP) Section on Pediatric Trainees (SOPT) registration scholarship to the 2022 virtual Advocacy Conference |
03/2023 Spring 2023 Hemostasis and Thrombosis Research Society (HTRS) Trainee Workshop |
12/2023 Medical College of Wisconsin Department of Pediatrics Grant Writing Retreat, Medical College of Wisconsin |
01/2024 - 06/2024 Medical College of Wisconsin Child Health Early Career Club (CHECC) grant writing program. , Medical College of Wisconsin |
04/2024 Spring 2024 Hemostasis and Thrombosis Research Society (HTRS) Trainee Workshop |
04/2024 Medical College of Wisconsin Department of Pediatrics Grant Writing Retreat, Medical College of Wisconsin |
11/2024 Medical College of Wisconsin Department of Pediatrics Grant Writing Retreat, Medical College of Wisconsin |
09/2025 Awarded from BloodNet, a pediatric critical care blood research network, that is part of PALISI (Pediatric Acute Lung Injury and Sepsis Investigators), Jacques Lacroix Junior Investigator Award |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
01/2016 - 07/2022 American College of Osteopathic Pediatricians (ACOP) (Member) |
07/2019 - Present National & Wisconsin Chapter of American Academy of Pediatrics (AAP) (Member) |
07/2022 - Present American Society of Hematology (Associate Member) |
11/2022 - Present Wisconsin Association of Osteopathic Physicians and Surgeons |
04/2023 - Present Hemostasis and Thrombosis Research Society (HTRS) (Trainee Member) |
08/2024 - Present International Society of Thrombosis and Haemostasis Associate (Member) |
06/2025 - Present American Heart Association Early Career (Member) |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
06/2020 - 06/2021 Lead Resident for Advocacy, Committee for Advocacy and Resident Education (CARE), UW-Madison Pediatric Residency Program (Madison, WI) |
04/2021 - 04/2022 Teacher, Pediatric Intern Prep Course Teacher, UW-Madison Pediatric Residency Program |
07/2021 - 06/2022 Resident National Program Delegate for advocacy, Section on Pediatric Trainees (SOPT), American Academy of Pediatrics |
11/01/2022 - Present Board Member, Student/Post-graduate committee, Wisconsin Association of Osteopathic Physicians and Surgeons (WAOPS) |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
Member, Pediatric Early Career Working Party, International Society of Thrombosis and Haemostasis (ISTH) |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
IL-6 Stimulation Increases Fucosylation and Changes Sialylation Patterns of Platelets Stimulated by a Specific GPVI Agonist: Unraveling Thromboinflammation, BloodNet Fall Meeting at Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Fall Conference, Quebec, Canada, 2025 |
National |
Brenner, Michelle, Renal Vein thrombosis in a Pre-teen, Hemostasis and Thrombosis Research Society (HTRS) Clinical Fellows Network, 2024 |
Local |
Brenner, Michelle, Platelets 101, Versiti Blood Research Institute Thrombosis and Hemostasis Summer Lecture Series, Versiti Blood Research Institute, 2024 |
The Red Flag: Recognizing and Treating Anemia, Wisconsin Association of Osteopathic Physicians and Surgeons Board Member (WAOPS) Fall Conference, Pewaukee, Wisconsin, 2025 |
COMMITTEE SERVICE: |
Hospital |
07/01/2025 - Present Member, Venous Thromboembolism (VTE) Anticoagulation Workgroup, Children's Wisconsin |
MCW TEACHING ACTIVITIES: |
Resident and Fellow Education |
2025 Ace the Boards: Hematology Review |
EXTRAMURAL TEACHING: |
Resident and Fellow Education |
04/2021 - 04/2022 UW-Madison Pediatric Residency Program (Madison, WI), Presented lectures on topics such as pediatric dermatology and defibrillation. Assisted with execution of and debriefing of simulated pediatric shock case. Lead simulated cases and discussion on appropriate informed consent. Developed and taught curriculum with mini simulations of indications and use of a defibrillator |
CONFERENCE ATTENDANCE : |
10/2012 14th Biennial Midwest Platelet Conference; Cleveland, OH |
06/2014 60th Annual International Society on Thrombosis and Haemostasis (ISTH) Scientific and Standardization Committee (SSC) Meeting; Milwaukee, WI |
10/2014 15th Biennial Midwest Platelet Conference; Chicago, IL |
06/2015 International Society on Thrombosis and Haemostasis (ISTH) Congress; Toronto, Canada |
07/2016 Des Moines University Mentored Summer Research Program Closing Program; Des Moines, Iowa |
12/2016 Des Moines University Research Symposium; Des Moines, Iowa |
04/2017 Experimental Biology; Chicago, Illinois |
12/2017 Des Moines University Research Symposium; Des Moines, Iowa |
03/2020 Wisconsin Chapter of the American Academy of Pediatrics (AAP) Advocacy Day; Madison, Wisconsin |
03/2021 Wisconsin Chapter of the American Academy of Pediatrics (AAP) Virtual Advocacy Day; Madison, Wisconsin |
04/2021 American Academy of Pediatrics (AAP) Virtual Advocacy Conference; Washington, DC |
05/2021 University of Wisconsin-Madison Department of Pediatrics Research Week; Madison, Wisconsin |
10/2021 AAP National Conference and Exhibition; Virtual |
03/2022 American Academy of Pediatrics (AAP) Virtual Advocacy Conference; Washington, DC |
05/2022 American Society of Pediatric and Hematology/Oncology Conference; Pittsburgh, Pennsylvania |
09/2023 Translational Glycomics Symposium; Milwaukee, Wisconsin |
11/2023 Society for Glycobiology Annual Meeting; Kona, Hawaii |
04/2024 Thrombosis and Hemostasis Summit of North America, Chicago, Illinois |
09/2024 Translational Glycomics Symposium; Milwaukee, Wisconsin |
10/2024 Wisconsin Association of Osteopathic Physicians and Surgeons Fall Conference, Madison, Wisconsin |
11/2024 Earl W. Davie Symposium, Vancouver, Canada |
12/2024 American Society of Hematology Conference, San Diego, California |
03/2025 Hemostasis and Thrombosis Research Society (HTRS) Conference, Coronado Bay, California |
09/2025 Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)/BloodNet Fall Conference, Montreal, Canada. |
12/2025 American Society of Hematology Conference, Orlando, Florida |
03/2026 Thrombosis and Hemostasis Summit of North America, Portland, Oregon. |
RESEARCH WORK EXPERIENCE: |
11/2006 - 05/2010 Undergraduate Research Assistant. UW-Madison Biochemistry Department (Madison, WI)
Collaborated with a graduate student to investigate pleiotropic drug resistance via over expression of molecular chaperone protein, ZUO1. Orally presented results each semester to lab group. Developed basic laboratory skills such as western blotting, PCR, and cloning. Prepared media, reagents, and other lab equipment for lab use
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2008 Product Development Intern. Blood Center of Wisconsin (Milwaukee, WI). Summer 2008
Evaluated clinical utility of an ELISA (Enzyme-Linked ImmunoSorbent Assay) for fibrinogen gamma prime detection. Analyzed the sensitivity of colorimetric, luminescent, and fluorescent ELISA designs. Isolated DNA from blood for use in a new blood genotyping platform |
06/2010 - 07/2015 Research Technologist II. Blood Research Institute, Blood Center of Wisconsin (Milwaukee, WI)
Analyzed effects of PECAM-1 as an inhibitor of platelet activation via cell transfection, culture, and analysis by flow cytometry. Investigated sequential regulation model for inhibitory receptors utilizing protein expression and purification and radioactive in-vitro kinase assays. Performed clinical research on bleeding and thrombosis in pediatric patients with congenital heart defects after cardiopulmonary bypass. Orally presented project data every month to lab group; Presented two posters and one oral presentation at national and international meetings |
06/2016 - 05/2017 Mentored Student Research Program Student Lab Assistant. Des Moines University (Des Moines, IA)
Compared mRNA expression patterns of various genes in the leucine metabolism pathway with and without various inhibitors in both T cells and cancer cells. Developed quantitative PCR assays. Prepared and presented three posters and one oral presentation
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BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Ananieva, EA, Bostic JN, Torres AA, Glanz HR, McNitt SM, Brenner MK, Boyer MP, Addington AK, and Hutson SM. Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma, Br. J. Cancer. 119(8): 1009-1017, 2018. |
2. Bercovitz RS, Brenner MK, and Newman DK. A whole blood model of thrombocytopenia that controls platelet count and hematocrit, Ann. Hematol. 95(11):1887-94, 2016. |
3. Brenner MK, Clarke S, Mahnke DK, Simpson P, Bercovitz RS, Tomita-Mitchell A, Mitchell ME, and Newman DK. Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery, Pediatric Research. 79(2):318-24, 2016. |
4. Tourdot BE, Brenner MK, Keough KC, Holyst T, Newman PJ, and Newman DK. Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM)-mediated Inhibitory Signaling is Regulated by Sequential Phosphorylation Mediated by Distinct Nonreceptor Tyrosine Kinases: A Case Study Involving PECAM-1, Biochemistry. 52(15):2597-608, 2013. |
5. Brenner, MK, Christopherson, PA, & Flood, VH (2025). (Un) Diagnosing von Willebrand disease. Hematology Am Soc Hematol Educ Program. 2025(1):127-130, 2025. |
Abstracts |
1. Brenner MK, Hoffmeister, K., and Branchford B. IL-6 Stimulation Increases Fucosylation and Changes Sialylation Patterns of Platelets Stimulated by a Specific GPVI Agonist: Unraveling Thromboinflammation. Hemostasis and Thrombosis Research Society (HTRS) Conference, Coronado Bay, CA (3/2025) Oral Presentation |
2. Brenner MK, Hoffmeister, K., and Branchford B. Characterization of Glycosylation Profile of Collagen-stimulated Platelets upon IL-6 Stimulation. Translational Glycomics Symposium, Milwaukee, Wisconsin (9/2024) Poster |
3. Brenner MK, Hoffmeister, K., and Branchford B. IL-6-Induced Potentiation of Platelet Activity and Glycosylation in Venous Thromboembolism. Thrombosis and Hemostasis Summit of North America, Chicago, Illinois (4/2024) Poster |
4. Brenner MK, Hoffmeister, K., and Branchford B. IL-6-Induced Potentiation of Platelet Activity and Glycosylation in Venous Thromboembolism. Society for Glycobiology Annual Conference, Kona, Hawaii (11/2023) Poster |
5. Brenner MK, Branchford, B, and Hoffmeister, K. Impact of IL-6 on Platelet Activity and Glycosylation: Implications for Venous Thromboembolism. Translational Glycomics Symposium, Milwaukee, Wisconsin (9/2023) Oral Presentation |
6. Brenner MK, Damodharan S, Ryan M, and Lee-Miller C. Characterization of CLABSI in a Pediatric Hematology/Oncology Population. American Society of Pediatric Hematology/Oncology Conference, Pittsburgh, Pennsylvania (5/2022) Poster |
7. Brenner MK, Damodharan S, Ryan M, and Lee-Miller C. “Those who fail to learn from the past are doomed to repeat it”: Characterization of Central Line Associated Bloodstream Infections (CLABSIs) at American Family Children’s Hospital (AFCH) from 2018-2020. University of Wisconsin-Madison Department of Pediatrics Research Week, Madison, Wisconsin (5/2021) Poster |
8. Ananieva EA, Bostic J, Torres A, Glanz H, McNitt S, Brenner MK, Boyer M, Addington A, Hutson S. Mice Deficient in the Mitochondrial Branched-Chain Aminotransferase (BCATm) Respond with Delayed Tumor Growth to a Challenge with EL-4 Lymphoma. Abstracts of Nutrition, Boston, Massachusetts (6/2018) Poster |
9. McNitt S, Brenner MK, Boyer M, Ananieva EA. Conditional T-cell Knockout of the Cytosolic Branched Chain Aminotransferase 1 (BCAT1) in Mice: Breeding Strategy. Des Moines University Research Symposium, Des Moines, Iowa (12/2017) Poster |
10. Brenner MK, Torres A, Hutson S, Ananieva EA. The Leucine Metabolic Pathway is Differentially Regulated by c-MYC and NFAT in T cells and their Cancerous Counterpart EL-4 Lymphoma Cells. Experimental Biology 2017, Chicago, Illinois (4/2017) Poster |
11. Brenner MK, Torres A, Ananieva EA. A Comparative Molecular Analysis of the Leucine Metabolic Pathway in T cells and EL-4 Lymphoma Cells. Des Moines University Research Symposium, Des Moines, Iowa (12/2016) Poster |
12. Brenner MK, Ananieva EA. A comparative genetic analysis of the leucine degrading enzymes in T lymphocytes and EL-4 lymphoma cells. Des Moines University Mentored Summer Research Program Closing Program, Des Moines, Iowa (7/2016) Oral Presentation |
13. Bercovitz RS, Brenner MK, Newman DK. A novel in vitro platelet transfusion model using a microfluidic perfusion assay. American Association of Blood Banks (AABB) Annual Meeting, Anaheim, California (10/2015) Oral Presentation |
14. Brenner MK, Bercovitz RS, Cole R, Niebler RA, Scott J, Stuth E, Mitchell ME, Woods R, Tweddell J, Benson DW, Newman DK. Assessment of platelet function and hemostasis in neonates undergoing cardiopulmonary bypass. International Society on Thrombosis and Haemostasis (ISTH) Congress, Toronto, Canada (6/2015) Oral Presentation |
15. Brenner MK, Clarke S, Bercovitz RS, Tomita-Mitchell A, Mitchell ME, Newman DK. Effect of 22q11.2 deletion on bleeding risk following cardiac surgery in children with congenital heart disease. 60th Annual International Society on Thrombosis and Haemostasis (ISTH) Scientific and Standardization Committee (SSC) Meeting, Milwaukee, WI (6/2014) Poster
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16. Bercovitz RS, Brenner MK, Newman DK. Development of a laboratory model of thrombocytopenia in human whole blood. 60th Annual International Society on Thrombosis and Haemostasis (ISTH) Scientific and Standardization Committee (SSC) Meeting, Milwaukee, WI (6/2014) Poster |
17. Brenner MK, Kofler M, Holyst T, Pawson T, and Newman DK. The Mechanistic Basis of PECAM-1 Phosphorylation by Fes/Fps. 14th Biennial Midwest Platelet Conference, Cleveland, OH (10/2012) Poster |
18. Tourdot BE, Brenner MK, Holyst T, Newman PJ, and Newman DK. ITIM-mediated Inhibitory Signaling is Regulated by Sequential Phosphorylation Mediated by Distinct Nonreceptor Tyrosine Kinases: A Case Study Involving PECAM-1. 14th Biennial Midwest Platelet Conference, Cleveland, OH (10/2012) Poster |
19. Brenner MK, Hoffmeister, K., and Branchford B. Characterization of Glycosylation Profile of Collagen-stimulated Platelets upon IL-6 Stimulation. Earl W. Davie Symposium, Vancouver, Canada (11/2024) Poster |
