CURRICULUM VITAE
Nita H. Salzman MD, PhD
Nita H. Salzman MD, PhD
Director, Professor
Department of Pediatrics
Division of Gastroenterology
Department of Pediatrics
Division of Gastroenterology
OFFICE ADDRESS: |
Medical Education Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
09/1979 - 06/1983 BA - Chemistry, Bryn Mawr College, Bryn Mawr, PA |
08/1983 - 06/1990 MD, New York University School of Medicine, New York, NY |
08/1983 - 06/1987 MS, New York University School of Medicine, Sackler Institute of Biomedical Sciences, New York, NY |
08/1983 - 06/1990 PhD, New York University School of Medicine, New York, NY |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
06/1990 - 06/1997 Resident, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA |
07/1994 - 06/1996 Postdoctoral Fellowship, Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, PA |
07/1996 - 06/1997 Post doctoral Fellowship, Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA |
FACULTY APPOINTMENTS: |
06/1990 - 06/1997 Assistant Instructor, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA |
07/1997 - 06/2001 Research Assistant Professor, Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA |
08/2001 - 06/2009 Assistant Professor, Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
08/2004 - Present Secondary Appointment, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI |
07/2009 - 06/2014 Associate Professor, Pediatrics, Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
07/2014 - Present Professor, Pediatrics, Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
ADMINISTRATIVE APPOINTMENTS: |
07/2005 - Present Director, GI Clinical Laboratory, Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
01/01/2013 - Present co-Leader, Immunology, Inflammation and Infection Research Unit, Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI |
01/01/2014 - Present Associate Director, Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI |
01/01/2016 - Present Director of Research, Pediatrics, Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
07/01/2016 - Present Scientific Director, Gnotobiotic mouse facility, Medical College of Wisconsin, Milwaukee, WI |
07/01/2016 - Present Director, Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
American Board of Pathology, Anatomic Pathology | 06/1994 | None |
Licensure | Number | Issue Date | Expiration |
Pennsylvania (inactive) | 049744 L | 1994 | None |
Wisconsin | 49506-020 | 07/2006 | None |
AWARDS AND HONORS: |
1983 Sigma Xi Scientific Honor Society |
1996 - 1998 Fellowship , Crohn's and Colitis Foundation of America |
2016 Women Pioneer in Research Award, Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
09/12/2017 - Present Medical College of Wisconsin Society for Research Excellence (member) |
American Gastroenterological Association (Member) |
American Association for the Advancement of Science (Member) |
American Society for Microbiology (Member) |
Society for Pediatric Research (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2011 - Present Infection and Immunity |
2016 - Present Gut Microbes |
02/01/2021 - Present Gut Microbes |
Journal Review |
2003 - Present Journal of Dairy Science |
2003 - Present Anaerobe |
2003 - Present Microbiology |
2004 - Present Infection and Immunity, Applied and Environmental |
2004 - Present Trends in Microbiology |
2005 - Present Pediatrics |
2007 - Present Gastroenterology |
2008 - Present J. Immunology |
2008 - Present Microbes and Infection |
2010 - Present Cell Host & Microbe |
2010 - Present Proceedings of the National Academy of Sciences |
2011 - Present Science |
2011 - Present Cellular Microbiology |
2012 - Present Nature Immunology |
2014 - Present PLOS Pathogens |
2014 - Present Molecular Cell |
2014 - Present Nature |
2016 - Present Science Translational Medicine |
2016 - Present Nature Microbiology |
2019 - Present mSphere |
2020 - Present Immunity |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2003 - 2011 Ad Hoc Reviewer, Crohn’s and Colitis Foundation of America |
2005 - 2007 Member, CSR Special Emphasis Panel, ZRG1 F07-L (20) Immunology Fellowships and AREA grants, NIH Study Section |
2005 - 2008 Member, Microbiology Focus Group-Crohn’s and Colitis Foundation of America |
2010 Reviewer, National Institute on Aging, program project review, NIH Study Section |
2010 Reviewer, Review of “Enteric Research Investigational Network Cooperative Research Centers (ERIN) Cooperative Research Centers (CRCs), NIH Study Section |
2011 - 2018 member, Research Training Grant Review Committee, Crohn's and Colitis Foundation of America |
2011 Reviewer, Targeting existence in Select Gram Negative Pathogens (R21/R33) Special Emphasis Panel, NIH NIAID |
2011 Reviewer, NIDDK Hepatobiliary Pathophysiology Study Section, NIH |
2011 Reviewer, CAREER proposal review, NSF |
2011 Vice Chair Elect, Gordon Research Conference on Antimicrobial |
2012 - 2102 Reviewer, Dynamics of Host Associated Microbial Communities Special Emphasis Panel, NIH NIGMS |
2012 - 2102 Reviewer, Ancillary Studies to Ongoing Clinical Studies in Areas of Interest to NIDDK, NIH NIDDK |
2013 Reviewer, Dynamics of Host Associated Microbial Communities Special Emphasis Panel, NIH NIGMS |
2013 Chair, Gordon Research Conference on Antimicrobial Peptides |
2013 Reviewer, Pilot and Feasibility Clinical Research Studies in Digestive Diseases and Nutrition Study Section, NIH NIDDK |
2013 Reviewer, Liver and Gastrointestinal Physiology, Pathology and Pharmacology Study Section, NIH NIDDK |
2013 - 2016 Ad Hoc Reviewer, Gastrointestinal Mucosal Pathobiology Study Section, NIH NIDDK |
2014 - 2017 Member, Scientific Advisory Board of the Broad Medical Research Foundation, Crohn's and Colitis Foundation of America |
2016 Reviewer, Exploratory Studies for Delineating Microbiome: Host Interactions in Obesity, Digestive and Liver Diseases and Nutrition (R21) Special Emphasis Panel, NIH NIDDK |
2016 - 2020 Member, Gastrointestinal Mucosal Pathobiology Study Section, NIH NIDDK |
2018 - 2020 vice-Chair, Research Training Award Review Committee, Crohn's and Colitis Foundation |
2018 - Present Member, National Advisory Committee, Crohn's and Colitis Foundation |
2018 Editorial Review Panel Member, NIH Director's New Innovator Award Program (DP2), NIH |
2020 Chair, Gastrointestinal Mucosal Pathobiology Study Section, NIH NIDDK |
2020 Reviewer, New Innovators Awards (DP2) Special Emphasis Panel, NIH NIAID |
2021 - Present Chair, Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory DIseases (DHMI) Study Section, NIH |
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
The Impact of Enteric Defensins on the Intestinal Microbiota, The Impact of Enteric Defensins, Barga, Italy, 2003 |
The role of enteric defensins in innate mucosal immunity, SBARIS, Tokyo, Japan, 2004 |
Intestinal Commensals and Innate Immunity, Innate Immunity and its Modulation in Inflammatory Bowel Disease, Stuttgart, Germany, 2005 |
Discussion Leader, Antimicrobial Peptides Gordon Research Conference, Barga, Italy, 2007 |
The Commensal Microbiota: From Homeostasis to Disease, A Peter Wall Institute for Advanced Studies and College de France Symposium, Paris, France, 2011 |
Defensins as Essential Regulators of Intestinal Microbial Ecology, Antimicrobial Peptides Gordon Conference, Barga, Italy, 2011 |
Antimicrobial peptides and the regulation of the intestinal microbiota, International Workshop on Intestinal Mucosal Homeostasis and Disease, Hannover, Germany, 2011 |
Paneth cells, antimicrobial peptides, and maintenance of intestinal homeostasis, University of Alberta, Edmonton, Alberta, Canada, 2012 |
Paneth cell defensins and intestinal homeostasis: host regulation of the microbiota, PWSE (Pancosma) meeting, Madrid, Spain, 2012 |
Antimicrobial Peptides and the Regulation of the Intestinal Microbiome: Implications for Intestinal Homeostasis, International Probiotics Association World Congress, Los Angeles, CA, 2012 |
Antimicrobial peptides from host and microbe contribute to intestinal homeostasis, Antimicrobial Peptides Gordon Conference, Barga, Italy, 2015 |
Niche competition in the gastrointestinal tract, Wenner-Gren Symposium on Host-Microbe Interaction in the Gut-From Model Systems to Human Disease, Stockholm, Sweden, 2016 |
Antimicrobial peptides and bacterial niche competition in the GI tract, Zing Conference on Antimicrobial Activity and Defense Strategies at the Mucosal Surface, Albufeira, Portugal, 2016 |
Two sides to intestinal homeostasis: Roles for both host and
microbial AMPs, Keynote Speaker, AMP2016, Montpellier, France, 2016 |
Microbiome-based therapeutics to eliminate intestinal colonization by multidrug-resistant bacteria, 27th ECCMID (European Congress of Clinical Microbiology
and Infectious Diseases), Vienna, Austria, 2017 |
Antimicrobial peptides and bacterial niche competition in the GI tract, Cold Spring Harbor Asia Conference on Bacterial Infection and Host Defense, Suzhou, China, 2017 |
National |
Innate Intestinal Host Defense: The Role of Defensins in the Small, UMDNJ, Jonty Foundation/The Austism Center Think Tank Conference, Somerset, NJ, 2003 |
Analysis of 16S Libraries of Mouse Intestinal Bacteria: "The Real Story of Enteric Flora", IBD Research-Junior Faculty Symposium, Chicago, IL, 2003 |
The Role of Enteric Defensins in Innate Mucosal Immunity, Cleveland Clinic Foundation, Cleveland, OH, 2004 |
The Role of Enteric Defensins in Innate Mucosal Immunity, California State University, Los Angeles, CA, 2005 |
Innate Mucosal Immunity and the Microbial Ecology of the GI Tract, Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2007 |
Innate Mucosal Immunity and the Microbial Ecology of the GI Tract, Department of Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA, 2008 |
Discussion Leader, Antimicrobial Peptides Gordon Research Conference, Ventura, CA, 2009 |
Session Moderator, Digestive Disease Week, Chicago, IL, 2009 |
Session Moderator, Digestive Disease Week, New Orleans, LA, 2010 |
The Intestinal Microbiome: Regulation, Perturbation, and Susceptibility to Salmonella Infection, Colloquium entitled “Pathogen modulation of the normal microbiota”, American Society for Microbiology 110th General Meeting, San Diego, CA, 2010 |
Paneth cells, antimicrobial peptides, and maintenance of intestinal homeostasis, Cincinnati Children’s Hospital, Cincinnati, OH, 2011 |
Paneth cells, defensins, and the regulation of the intestinal microbiota, PAS/ASPR, Denver, CO, 2011 |
Paneth cells: Host defense and the gut microbiome, The NIH Center for Molecular Studies in Digestive and Liver Diseases Penn/CHOP 13th Annual Symposium, “IBD, Functional Genomics and the Intestinal Mucosal Interface”,, Philadelphia, PA, 2012 |
Intestinal Host-Microbial Interactions: Implications for Host Immunity, NIA Advisory Committee Meeting on the Microbiome and Aging, Bethesda, MD, 2012 |
Bacterial-host dynamics at the intestinal mucosal interface, University of Minnesota, Minneapolis, MN, 2013 |
Bacterial-host dynamics at the intestinal mucosal interface, Dynamics of Host-Associated Microbial Communities, NIH, NIGMS, Bethesda, MD, 2013 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal homeostasis, New Jersey Medical School, Newark, NJ, 2014 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal homeostasis, Microbiology Seminar Series, Alumnae Day speaker, University of Pennsylvania School of Medicine, Philadelphia, PA, 2014 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal homeostasis, Case Western Reserve University School of Medicine, Department of Pathology, Cleveland, OH, 2014 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal homeostasis, Albert Einstein College of Medicine, Department of Pediatrics, Bronx, NY, 2015 |
Paneth cells, the microbiome, and Crohn’s disease susceptibility, University of Nebraska Medical Center, Omaha, NE, 2015 |
Assessment of the effects of microbiome composition in pediatric
NAFLD., 2015 Annual Meeting of the American Society for Human Genetics, Session: Genetic Control of the Microbiome, Baltimore, MD, 2015 |
Paneth cell dysfunction, dysbiosis, and Crohn’s disease, Experimental Biology 2015, Boston, MA, 2015 |
The Microbiome, the Immune System and Intestinal Homeostasis: A
Delicate Balance, Association for Molecular Pathology AMP2015 Annual Meeting, Austin, Texas, 2015 |
The CCFA Microbiome Project, CCFA Gala, Northern California Chapter, San Francisco, CA, 2015 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal
homeostasis, University of North Carolina, Chapel Hill, NC, 2015 |
The Microbiome, the Immune System and Intestinal Homeostasis: A
Delicate Balance, Stanley Manne Children’s Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL, 2016 |
Antimicrobial peptides shape intestinal niche creation and competition, NIH workshop, The Human Microbiome: Emerging Themes at the Horizon of the 21st Century, Bethesda, MD, 2017 |
Genetics, Environment and the Microbiome: Implications for Human
Health and Disease, DOHaD Society Meeting, Chapel Hill, NC, 2018 |
Antimicrobial peptides and intestinal homeostasis: Contributions of both host and microbe, University of Iowa Carver College of Medicine, Iowa City, IA, 2018 |
Antimicrobial peptides and intestinal homeostasis: Contributions of both host and microbe, Vanderbilt University School of Medicine, Nashville, TN, 2018 |
Antimicrobial Peptides: Mediators of Bacterial Niche Competition in the GI Tract, University of Washington, Seattle, WA, 2018 |
Enterococcus colonization and competition in the GI tract, Tri-I Immunology and Microbial Pathogenesis Program Research Seminar Series, Sloan Kettering Institute, Rockefeller University, Weill Cornell Medical College, New York, NY, 2018 |
Antimicrobial peptides and intestinal homeostasis: Contributions of both host and microbe, University of Toledo College of Medicine, Toledo, OH, 2018 |
Paneth Cells in Host Defense and Homeostasis. State-of-the-art lecture., Digestive Disease Week (DDW) 2018, Washington, DC, 2018 |
Antimicrobial peptides and bacterial niche competition in the GI tract, Department of Molecular Genetics & Microbiology Symposium entitled “Harnessing Immunity to Combat Infection and Disease”, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, 2019 |
Enterococcus colonization and competition in the GI tract, Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 2019 |
Antimicrobial peptides and intestinal homeostasis: Contributions of both host and microbe., Department of Biology, Bryn Mawr College, Bryn Mawr, PA, 2019 |
Antimicrobial peptides and intestinal homeostasis: Contributions of both host and microbe, Spring Lecture Series on Cellular Homeostasis 2019, University of Southern California, Los Angeles, CA, 2019 |
The intestinal microbiome in pediatric NAFLD, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), virtual, 2020 |
N.H. Salzman, The intestinal microbiome in Pediatric NAFLD, Digestive Disease Research Center Seminar, Vanderbilt University School of Medicine, virtual, 2021 |
The intestinal microbiome and host protection from enterococcus infection, Digestive Disease Week, virtual, 2021 |
Regional |
The Role of Enteric Defensins in Innate Mucosal Host Defense, Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI, 2003 |
The Role of Enteric Defensins in Innate Mucosal Immunity, Ripon College, Ripon, WI, 2004 |
The Role of Intestinal Defensins in Innate Mucosal Immunity, 11th Annual Midwest Microbial Pathogenesis Conference, Lansing, MI, 2004 |
Paneth cells, the microbiome and intestinal homeostasis: Implications for the development of Crohn’s disease, Concordia University, School of Pharmacy, Mequon, WI, 2012 |
Paneth cells, the microbiome and IBD, CCFA Patient and Family Education Program, Illinois chapter of the CCFA, Palatine, IL, 2015 |
Two sides to intestinal homeostasis: roles for both host and microbial
antimicrobial peptides, 9th Annual Center for Human Immunology Symposium: The
Impact of the Microbiome on Immunity, Blood Research Institute, Wauwatosa, WI, 2015 |
Characterizing and Targeting the Microbiome in Human Disease, BioForward Wisconsin Speaker Series: Introducing the Microbiome, Milwaukee, WI, 2016 |
Antimicrobial peptides: Mediators of intestinal colonization,
homeostasis and defense, Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI, 2017 |
Local |
Human Defensin 5 Transgenic Mice: An In Vivo Model of Defensin Function, Children's Hospital of Wisconsin, Department of Pediatrics, Milwaukee, WI, 2002 |
The Role of Enteric Defensins in Mucosal Immunity, MCW Digestive Disease Center Research Seminar, Milwaukee, WI, 2002 |
Human Defensin 5 Transgenic Mice: An In Vivo Model of Defensin Function, MCW Department of Microbiology and Molecular Genetics, Milwaukee, WI, 2002 |
The Role of Defensins in Mucosal Protection of the Gastrointestinal Tract, MCW Digestive Disease Center Advisory Board, Milwaukee, WI, 2002 |
Enteric Defensins and the Regulation of the Intestinal Microbiota, MCW Department of Microbiology and Molecular Genetics, Milwaukee, WI, 2003 |
Defending the GI tract: the role of defensins in host-microbe interactions, Children’s Hospital of Wisconsin, Department of Pediatrics, Milwaukee, WI, 2005 |
The Role of Defensins in Innate Mucosal Immunity, MCW Department of Microbiology and Molecular Genetics, Milwaukee, WI, 2007 |
Innate Mucosal Immunity and the Microbial Ecology of the GI Tract, Medical College of Wisconsin, Department of Medicine, Division of Infectious Diseases, Milwaukee, WI, 2007 |
The GI microbiota, mucosal immunity, and the “Microflora Hypothesis” of allergic disease, Department of Pediatrics, Division of Allergy and Immunology, Children’s Hospital of Wisconsin, Milwaukee, WI, 2008 |
Go with your gut: the intestinal microbiome in health and disease, Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI, 2008 |
Studies of the intestinal microbiome: Applicability to basic and translational research, Department of Pediatrics, Division of Gastroenterology, Milwaukee, WI, 2008 |
Inate Immune Regulation of Intestinal Microbial Ecology, 2008 Pediatric Research Symposium, Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI, 2008 |
A niche of one’s own: Bacteria-biome-mucosal immune interactions, Medical College of Wisconsin, Department of Medicine, Division of Infectious Diseases, Milwaukee, WI, 2010 |
Impact of the immune system on the microbiome, Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI, 2010 |
Medical College of Wisconsin Microbiome Project, IBD Family Forum, Children’s Hospital of Wisconsin, Milwaukee, WI, 2011 |
The role of the intestinal microbiome in immunology and allergic disease, Department of Pediatrics, Division of Allergy and Immunology, Children’s Hospital of Wisconsin, Milwaukee, WI, 2011 |
Paneth cells, the microbiome and intestinal homeostasis: Implications for the development of Crohn’s disease, Children's Research Institute Seminar, Children's Hospital of Wisconsin, Milwaukee, WI, 2012 |
Paneth cells, antimicrobial peptides, and the microbiota: Détente at mucosal surfaces, Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital of Wisconsin, Milwaukee, WI, 2012 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal
homeostasis, Department of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI, 2014 |
Enterococcus faecalis dynamics in the gut: finding and defending
your niche, Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 2014 |
Enterococcus faecalis niche formation in the GI tract: at least two sides to the story, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 2014 |
Paneth cells, antimicrobial peptides, and the regulation of intestinal homeostasis, CTSI, Medical College of Wisconsin, Milwaukee, WI, 2014 |
Paneth cells, the microbiome, and Crohn’s disease, Digestive Disease Center Advisory Board Meeting, Medical College of Wisconsin, Milwaukee, WI, 2015 |
Obtaining grant funding: Persistence Pays!, Department of Pediatrics K Club, Medical College of Wisconsin, Milwaukee, WI, 2015 |
The Microbiome, the Immune System and Intestinal Homeostasis: A
Delicate Balance, Department of Pediatrics, Children’s Hospital of Wisconsin,
Children’s Research Institute Seminar, Milwaukee, WI, 2015 |
Microbial Niche Competition in the GI Tract, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 2015 |
Good Bugs, Bad Bugs, the Microbiome and You, “It’s contagious: inside the world of infectious disease”, Conversations with Scientists. Advancing a Healthier Wisconsin, Medical College of Wisconsin, Milwaukee, WI, 2016 |
Characterizing and Targeting the Microbiome in Human Disease, Children's Research Institute Golden Angels Meeting, Milwaukee, WI, 2016 |
The microbiome and allergy, Division of Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Wisconsin, Milwaukee, WI, 2016 |
The Microbiome, the Immune System and Intestinal Homeostasis: A
Delicate Balance, Children’s Hospital of Wisconsin Board Meeting, Medical College of Wisconsin, Milwaukee, WI, 2016 |
The Microbiome in Health and Disease, 10th Annual Diabetes Symposium of Wisconsin, Milwaukee, WI, 2017 |
Creating and defending your niche: antimicrobial production and
resistance, UW Microbiology Club, Milwaukee, WI, 2017 |
Antimicrobial peptides and intestinal homeostasis: Contributions of both host and microbe, Department of Obstetrics and Gynecology Research Seminar, Medical College of Wisconsin, Milwaukee, WI, 2018 |
The microbiome in health and disease, Milwaukee Academy of Medicine, Milwaukee, WI, 2018 |
A role for the microbiome in pediatric NAFLD, Children's Research Institute Seminar, Children’s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, 2018 |
Therapeutic bacteria to prevent multidrug-resistant enterococcal infections, First Look Forum Event: What’s Brewing in MKE?, Milwaukee, WI, 2018 |
A role for the microbiome in pediatric NAFLD, Inaugural Dean’s Hour seminar series, Medical College of Wisconsin, Milwaukee, WI, 2019 |
A role for the microbiome in pediatric NAFLD, Pediatric GI divisional meeting, Medical College of Wisconsin, Milwaukee, WI, 2019 |
The intestinal microbiome in pediatric NAFLD, Children's Research Institute Seminar Series, Children's Hospital of Wisconsin, Milwaukee, WI, 2020 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Inhibition of Paneth Cell Antimicrobial Peptide Expression Following Salmonella Infection Requires SPI1 Type III Secretion, Antimicrobial Peptides Gordon Conference, Ventura, CA, 2001 |
Regulation of the Intestinal Microbiota by Paneth Cell Defensins, Antimicrobial Peptide Gordon Conference, Ventura, CA, 2005 |
Enteric Defensins are Essential Regulators of Intestinal Microbial, Antimicrobial Peptides Gordon Conference, Barga, Italy, 2007 |
Chakraborty, R. J. Stromich, D. Bretl, M. Hayward, C. Kristich, and N.H. Salzman, Enterococcus faecalis dynamics in the gastrointestinal tract: Interaction between antibiotics, microbiota and antimicrobial peptides, Gordon Research Conference on Antimicrobial Peptides, Ventura, CA, 2013 |
Kommineni, S., M. Hayward, Bretl, D., P. Bousounis, C. J. Kristich, and N.H. Salzman, Factors associated with bacteriocin encoding plasmid dependent Enterococcus faecalis colonization in the GI tract, Gordon Research Conference on Antimicrobial Peptides, Ventura, CA, 2013 |
Liu, T. C., B. Gurram, V. Lam, M. Baldridge, R. Head, M. Stephens, D. Lerner, M. Hayward, P. Bousounis, M. Holtz, Y. Cao, P. Simpson, H. Virgin, T. Stappenbeck and N. H. Salzman, Paneth cells, the microbiome, and Crohn’s disease susceptibility, Antimicrobial Peptides Gordon Conference, Barga, Italy, 2015 |
Kommineni, S., D. Bretl, V. Lam, R. Chakraborty, M. Hayward, P. Bousounis, C. J. Kristich and N. H. Salzman, Bacteriocin production augments niche competition by
enterococci in the mammalian GI tract, Antimicrobial Peptides Gordon Conference, Barga, Italy, 2015 |
National |
Increased Enteric Defensin Expression in Necrotizing Enterocolitis, Society for Pediatric Research, Annual Meeting, Washington, DC, 1996 |
Oral Infection with S. typhimurium Causes Down-regulation of Enteric Antimicrobial Peptide Expression, Keystone Symposia on Molecular and Cellular Biology. Innate and Acquired Immunity at Mucosal Surfaces, Taos, NM, 2000 |
Human Defensin 5 Transgenic Mice: An In Vivo Model of Defensin Function, Digestive Disease Week, AGA, Distinguished Plenary Presentation, San Francisco, CA, 2002 |
Enteric Defensins are Essential Regulators of Intestinal Microbial Ecology, SPR Research Conference, 2007 |
Enteric Defensins are Essential Regulators of Intestinal Microbial Ecology, ASM Conference on Beneficial Microbes, San Diego, CA, 2008 |
Kommineni, S., M. Hayward, P. Bousounis, C. J. Kristich, and N.H. Salzman, Factors associated with Enterococcus faecalis colonization in the GI tract, 2013 Molecular Genetics of Bacteria and Phages Conference, Madison, WI, 2013 |
Gurram, B., Stephens, M., V. Lam, M. Hayward, P. Bousounis, U. Broeckel, E. Worthey,
P. Simpson, and N.H. Salzman, Paneth Cells, the Microbiome, and Crohn’s Disease
Susceptibility, IBD Advances Meeting, Hollywood, FL, 2013 |
Liu, T.C., N.H. Salzman, C.A. Arnold, and T.S. Stappenbeck, Evolution of Paneth Cell Phenotype in Crohn's Disease: Implications for Disease Etiopathogenesis, Digestive Disease Week, Chicago, IL, 2014 |
Kommineni, S., M. Hayward, P. Bousounis, C. J. Kristich, and N.H. Salzman, The Bacteriocin-21 confers a competitive advantage for E. faecalis intestinal colonization through competition, conjugation, and microbiome manipulation, ASM Conference on Beneficial Microbes, Washington, DC, 2014 |
Simpson P, Pan A (Cao Y), Huang B, Johnson J, Schwimmer J, Holtz M, Weinstock G,
Weinstock E, Salzman N., For the microbiome, zeroes are definitely of non-zero
importance, Joint Statistical Meetings, Chicago, IL, 2016 |
Banla, I., M. Hayward, N.H. Salzman and C.J. Kristich, Determinants of Enterococcus
faecalis cell envelope integrity and antimicrobial resistance modulate intestinal
colonization in mice, 2016 Molecular Genetics of Bacteria and Phages Conference, Madison, WI, 2016 |
Schwimmer JB, Newton KP, Africa J, Durelle J, Arroyo S, Bross C, Behling C, Hamilton G, Sirlin CB, Borecki I, Mitreva M, Tyagi R, Belt P, Yates KP, Lavine JL, Johnson J, Sodergren E, Weinstock G, Holtz M, Simpson P, Salzman N., The intestinal microbiome in children with nonalcoholic fatty liver disease: A case-control study., Digestive Disease Week, San Diego, CA, 2016 |
Jennings KC, Banla I, Kristich C, Salzman NH, Growth phase and osmotic stress drive
subcellular localization of Enterococcus faecalis OGIRF_11271, a conserved protein
involved in cell envelope integrity., Molecular Genetics of Bacteria and Phages
Meeting, Madison, WI, 2019 |
Regional |
Regulation of the Intestinal Microbiota by Paneth Cell Defensins, Digestive Disease Week, AGA, Poster of Distinction, Chicago, IL, 2005 |
Reduced Paneth cell alpha-defensin expression in Crohn's Disease of the ileum, Digestive Disease Week, AGA, Poster of Distinction, Chicago, IL, 2005 |
Banla, I.L., M. Hayward, N.H. Salzman and C.J. Kristich, Stable and long-term
colonization of the murine GI tract by E. faecalis is dependent on ireK, Midwest
Microbial Pathogenesis Conference, Indianapolis, IN, 2015 |
Chakraborty, R., J. Stromich, M. Hayward, T. Nelson, C.J. Kristich, and N.H. Salzman, The role of the innate immune system in systemic enterococcus dissemination and
clearance, Midwest Microbial Pathogenesis Conference, Indianapolis, IN, 2015 |
Banla I, Kommineni S, Hayward M, Kristich C, Salzman N., Contributions of
Enterococcus faecalis Cell Surface Proteins to Intestinal Colonization, 9th Annual
Immunology Conference, Blood Research Institute, Milwaukee, WI, 2017 |
Chakraborty R, Stromich J, Bretl D, Hayward M, Kristich C, Salzman N., Role of the
Innate Immune System in Systemic Enterococcus Dissemination and Clearance, 9th
Annual Immunology Conference, Blood Research Institute, Milwaukee, WI, 2017 |
Chakraborty R, Lam V, Kommineni S, Stromich J, Hayward M, Kristich C, Salzman N., Ceftriaxone-mediated dynamics between the host, microbiota and enterococci in mouse
gastrointestinal tract., 12th Annual Immunology Conference, Blood Research Institute
(Versiti), Milwaukee, WI, 2019 |
Local |
Jennings K, Chakraborty R, Kristich C, Salzman N., Mononuclear phagocytes respond
to ceftriaxone-induced Enterococcus faecalis dissemination, 11th Annual Immunology
Scientific Retreat, MCW, Milwaukee, WI, 2020 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2004 Member, Basic Science Innovation Task Force, Department of Pediatrics, Medical College of Wisconsin |
07/2005 - 06/2008 Member, Institutional Animal Care and Use Committee, Medical College of Wisconsin |
2005 - 2006 Member, Task Force on Confict of Interest, Department of Pediatrics, Medical College of Wisconsin |
2006 Member, Biophotonic Core Oversight Committee, Medical College of Wisconsin |
2006 Member, “Advancing a Healthier Wisconsin” Scientific Peer Review Panel, Medical College of Wisconsin |
2006 Chair, DDC grant review committee, Medical College of Wisconsin |
2010 Member, DDC grant review committee |
2011 - 2014 Member, Faculty Career Development Committee, Medical College of Wisconsin |
2013 - Present Member, Internal NIH grant review committee, Department of Pediatrics |
2016 Member, Bioinformatics Faculty Advisory Group |
2019 - Present Member, University Rank and Tenure Committee |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
2001 - 2008 Lab Instructor, Microbiology |
2011 New Curriculum Development |
2013 - 2018 Instructor, GI and Nutrition Unit |
2017 - Present Lecturer, Infectious Agents and Host Immunity (IAHI) |
Graduate Student Education |
2009 - Present Instructor, Mucosal Pathogenesis |
2010 - Present Instructor, Mucosal Immunology |
2014 - 2019 Instructor, Cellular and Molecular Immunology |
2017 - Present Instructor, Translational Genetics |
2017 - 2019 Instructor, Cellular Microbiology |
2019 - Present Instructor, Integrated Curriculum |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
2021 Miranda Lyles, CTSI 500 Stars Summer Internship, MCW |
Graduate Students |
PhD Students Advised |
2021 - Present Sritejasvinithi Karimikonda, MCW |
PROGRAMMATIC DEVELOPMENTS: |
Research Programs |
2016 - Present Center for Microbiome Research |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011 Jul 22;35(1):109-22. PMCID: PMC3295638 |
2. Zimmerman, N.P., Vongsa, R.A., Faherty, S.L., SALZMAN, N.H., and M.B. Dwinell. Targeted intestinal epithelial deletion of the chemokine receptor CXCR4 reveals important roles for extracellular-regulated kinase-1/2 in restitution. Lab Invest. Epub 2011 May 2. PMID: 21537329 |
3. Duerr, C.U., N.H. SALZMAN, A. Dupont, A. Szabo, B.H. Normark, S. Normark, R.M. Locksley, P. Mellroth, and M.W. Hornef. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Mucosal Immunology, 2010, (27 October 2010) doi:10.1038/mi.2010.71. |
4. Biswas, A., Y. Liu, L. Hao, A. Mizoguchi, N.H. SALZMAN, C.L. Bevins, and K.S. Kobayashi. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc. Natl. Acad. Sci. 2010, 107(33): 14739-14744. PMID: 20679225 |
5. SALZMAN, N.H., K. Hung, D. Haribhai, H. Chu, J. Karlsson-Sjoberg, E. Amir, P. Teggatz, M. Barman, M. Hayward, D. Eastwood, M. Stoel, Y. Zhou, E. Sodergren, G.M. Weinstock, C.L. Bevins, C.B. Williams, and N.A. Bos. Enteric defensins are essential regulators of intestinal microbial ecology. Nature Immunology, 2010, 11(1): 76-83. published online 22 October 2009; doi:10.1038/ni.1825. PMID: 19855381 |
6. Croswell, A., E. Amir, P. Teggatz, M. Barman, and N.H. SALZMAN. Prolonged Impact of Antibiotics on Intestinal Microbial Ecology and Susceptibility to Enteric Salmonella Infection. Infection and Immunity, 2009, 77(7):2741-53. PMCID: PMC2708550 |
7. Haribhai, D., Lin, W., Edwards, B., Ziegelbauer, J., SALZMAN, N.H., Carlson, M.R., Li, S-H., Simpson, P.M., Chatila, T.A., and C. B. Williams. A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis. J. Immunol. 2009, 182(6): 3461-8. |
8. Underwood, M.A., SALZMAN, N.H., Bennett, S.H., Barman, M., Mills, D.A., Marcobal, A., Tancredi, D.J., Bevins, C.L., and M.P. Sherman. A Randomized Placebo-controlled Comparison of Two Prebiotic/Probiotic Combinations in Preterm Infants: Impact on Weight Gain, Intestinal Microbiota, and Fecal Short Chain Fatty Acids. J. Pediatr. Gastroenterol. Nutr. 2009 48(2):216-225. |
9. Pechous, R.D., McCarthy, T.R., Mohapatra, N.P., Soni, S., Penoske, R.M., SALZMAN, N.H., Frank, D.W., Gunn, J.S., and T.C. Zahrt. A Francisella tularensis Schu S4 Purine Auxotroph is Highly Attenuated in Mice but Offers Limited Protection Against Homologous Intranasal Challenge. PLoS ONE 2008 Jun 25; 3(6); e2487. |
10. Barman, M., D. Unold, K. Shifely, E. Amir, K. Hung, N. A. Bos, and N.H. SALZMAN. Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract. Infection and Immunity, 2008: 76(3): 907-915. |
11. Olivier, V., N.H. SALZMAN, K. J. Fullner Satchell. Prolonged Colonization of Mice by Vibrio cholerae El Tor O1 Depends on Accessory Toxins. Infection and Immunity, 2007: 75(10): 5043-5051. |
12. Wehkamp, J., N. H. SALZMAN, E. Porter, M. Weichenthal, R. E. Petras, B. Shen, E. Schaeffeler, M. Schwab, R. Linzmeier, R. W. Feathers, H. Chu, H. Lima, K. Fellermann, T. Ganz, E. F. Stange, and C. L. Bevins. Reduced Paneth cell -defensin expression in Crohn's Disease of the ileum. Proc. Natl. Acad. Sci. 2005; 102 (50): 18129-18134. |
13. SALZMAN, N. H., D. Ghosh, K. Huttner, J. Russell, Y. Paterson, and C. Bevins. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 2003: 422:522-526. |
14. SALZMAN, N. H., M. Chou, H. deJong, L. Liu, E.M. Porter, and Y. Paterson. Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression. Infection and Immunity, 2003: 71(3): 1109-1115. |
15. SALZMAN, N. H., H. de Jong, Y. Paterson, H. J. M. Harmsen, G. W. Welling and N. A. Bos. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology 2002; 148: 3651-3660 |
16. Chen, C. N., L. D. McVay, Z. S. Batlivala, S. K. Hendren, G. P. Swain, N. SALZMAN, N. N. Williams, J. L. Rombeau. Anatomic and functional characteristics of the rat ileal pouch. Am. J. Surg. 2002: 183(4): 464-470. |
17. SALZMAN, N. H., R. A. Polin, M. C. Harris, E. Ruchelli, A. Hebra, S. Zirin-Butler, and C. Bevins. 1998. Enteric defensin expression in necrotizing enterocolitis. Pediatric Research 44(1): 20-26. |
18. SALZMAN, N.H., E. B. Mallow, A. Harris, J.P. Russell, R.J. DeBerardinis, E. Ruchelli, and C.L. Bevins. 1996. Human enteric defensins: Gene structure and developmental expression. J. Biol. Chem. 271(8): 4038-4045. |
19. SALZMAN, N.H., and F.R. Maxfield. 1989. Fusion-accessibility of endocytic compartments along the recycling and lysosomal endocytic pathways in intact cells. J. Cell Biol. 109: 2097-2104. |
20. SALZMAN, N.H., and F.R. Maxfield. 1988. Intracellular fusion of sequentially formed endocytic compartments. J. Cell Biol. 106:1083-1091. |
21. Cais, R.E., J.M. Kometani, and N.H. SALZMAN, 1986. NMR characterization of the chemical microstructure of vinylidene halide and vinyl halide copolymers. Macromolecules 19: 1006-1012. |
22. Cais, R.E., J.M. Kometani, and N.H. SALZMAN, 1983. Analysis of the chemical microstructure of copolymers by high-resolution nuclear magnetic resonance spectroscopy. Analytical Proceedings 20: 579-582. |
23. Bevins CL, Salzman NH. The potter's wheel: the host's role in sculpting its microbiota. Cell Mol Life Sci. 2011 Nov;68(22):3675-85. PMCID: PMC3222938 |
24. Martinez Rodriguez NR, Eloi MD, Huynh A, Dominguez T, Lam AH, Carcamo-Molina D, Naser Z, Desharnais R, Salzman NH, Porter E. Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection. Infect Immun. 2012 Jan;80(1):266-75. PMCID: PMC3255647 |
25. Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE. Intestinal microbiota determine severity of myocardial infarction in rats. FASEB J. 2012 Apr;26(4):1727-35. PMCID: PMC3316900 |
26. Lam V, Moulder JE, Salzman NH, Dubinsky EA, Andersen GL, Baker JE. Intestinal microbiota as novel biomarkers of prior radiation exposure. Radiat Res. 2012 May;177(5):573-83. |
27. Ray A, Basu S, Williams CB, Salzman NH, Dittel BN. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol. 2012 Apr 01;188(7):3188-98. PMCID: PMC3311743 |
28. Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ. Alternative luminal activation mechanisms for paneth cell α-defensins. J Biol Chem. 2012 Mar 30;287(14):11205-12. PMCID: PMC3322892 |
29. Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB. IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol. 2012 Dec 15;189(12):5638-48. PMCID: PMC3537488 |
30. Ristow LC, Miller HE, Padmore LJ, Chettri R, Salzman N, Caimano MJ, Rosa PA, Coburn J. The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks. Mol Microbiol. 2012 Sep;85(6):1105-18. PMCID: PMC3438374 |
31. Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27;337(6093):477-81. PMCID: PMC4332406 |
32. Bretl DJ, He H, Demetriadou C, White MJ, Penoske RM, Salzman NH, Zahrt TC. MprA and DosR coregulate a Mycobacterium tuberculosis virulence operon encoding Rv1813c and Rv1812c. Infect Immun. 2012 Sep;80(9):3018-33. PMCID: PMC3418728 |
33. Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E. Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J Immunol. 2013 Jun 01;190(11):5676-88. PMCID: PMC3659955 |
34. Schmitt EG, Haribhai D, Jeschke JC, Co DO, Ziegelbauer J, Yan K, Iwakura Y, Mishra MK, Simpson P, Salzman NH, Williams CB. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol. 2013 Dec 01;191(11):5460-76. PMCID: PMC3893829 |
35. Salzman NH, Bevins CL. Dysbiosis--a consequence of Paneth cell dysfunction. Semin Immunol. 2013 Nov 30;25(5):334-41. |
36. Korn LL, Thomas HL, Hubbeling HG, Spencer SP, Sinha R, Simkins HM, Salzman NH, Bushman FD, Laufer TM. Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells. Mucosal Immunol. 2014 Sep;7(5):1045-57. PMCID: PMC4107180 |
37. Rumman N, Sultan M, El-Chammas K, Goh V, Salzman N, Quintero D, Werlin S. Calprotectin in cystic fibrosis. BMC Pediatr. 2014 May 29;14:133. PMCID: PMC4048584 |
38. Porter E, Valore EV, Anouseyan R, Salzman NH. Detection of antimicrobial (poly)peptides with acid urea polyacrylamide gel electrophoresis followed by Western immunoblot. Methods Mol Biol. 2015;1225:105-15. |
39. Zhang Q, Abel H, Wells A, Lenzini P, Gomez F, Province MA, Templeton AA, Weinstock GM, Salzman NH, Borecki IB. Selection of models for the analysis of risk-factor trees: leveraging biological knowledge to mine large sets of risk factors with application to microbiome data. Bioinformatics. 2015 May 15;31(10):1607-13. PMCID: PMC4426830 |
40. Salzman NH. The role of the microbiome in immune cell development. Ann Allergy Asthma Immunol. 2014 Dec;113(6):593-8. |
41. Bartlett JA, Meyerholz DK, Wohlford-Lenane CL, Naumann PW, Salzman NH, McCray PB Jr. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015 May;8(5):501-8. PMCID: PMC4415896 |
42. Ray A, Basu S, Gharaibeh RZ, Cook LC, Kumar R, Lefkowitz EJ, Walker CR, Morrow CD, Franklin CL, Geiger TL, Salzman NH, Fodor A, Dittel BN. Gut Microbial Dysbiosis Due to Helicobacter Drives an Increase in Marginal Zone B Cells in the Absence of IL-10 Signaling in Macrophages. J Immunol. 2015 Oct 01;195(7):3071-85. PMCID: PMC4575870 |
43. Kommineni S, Bretl DJ, Lam V, Chakraborty R, Hayward M, Simpson P, Cao Y, Bousounis P, Kristich CJ, Salzman NH. Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract. Nature. 2015 Oct 29;526(7575):719-22. PMCID: PMC4978352 |
44. Gurram B, Salzman NH, Kaldunski ML, Jia S, Li BU, Stephens M, Sood MR, Hessner MJ. Plasma-induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment-naive paediatric inflammatory bowel disease. Clin Exp Immunol. 2016 Apr;184(1):36-49. PMCID: PMC4778097 |
45. Gurram B, Hammelev E, Syverson G, Haribhai D, Yan K, Simpson P, Salzman N, Verbsky JW. Intact Regulatory T-Cell Function but Defective Generation of IL-17A-Producing CD4+ T Cells in XIAP Deficiency. J Pediatr Gastroenterol Nutr. 2016 Aug;63(2):218-25. |
46. Haribhai D, Ziegelbauer J, Jia S, Upchurch K, Yan K, Schmitt EG, Salzman NH, Simpson P, Hessner MJ, Chatila TA, Williams CB. Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis. J Immunol. 2016 Apr 15;196(8):3305-17. PMCID: PMC4851766 |
47. Liu TC, Gurram B, Baldridge M, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz M, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern D, Xavier R, Stappenbeck T, Salzman N. O-011 Paneth Cell Phenotypes Define a Subtype of Pediatric Crohn's Disease Through Alterations in Host-Microbial Interactions. Inflamm Bowel Dis. 2016 Mar;22 Suppl 1:S4. |
48. Lam V, Su J, Hsu A, Gross GJ, Salzman NH, Baker JE. Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats. PLoS One. 2016;11(8):e0160840. PMCID: PMC4978455 |
49. Kommineni S, Kristich CJ, Salzman NH. Harnessing bacteriocin biology as targeted therapy in the GI tract. Gut Microbes. 2016 Nov;7(6):512-517. PMCID: PMC5153615 |
50. Liu TC, Gurram B, Baldridge MT, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz ML, Bousounis P, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern DP, Xavier RJ, Stappenbeck TS, Salzman NH. Paneth cell defects in Crohn's disease patients promote dysbiosis. JCI Insight. 2016 Jun 02;1(8):e86907. PMCID: PMC5033844 |
51. Pan P, Lam V, Salzman N, Huang YW, Yu J, Zhang J, Wang LS. Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats. Nutr Cancer. 2017;69(6):943-951. PMCID: PMC6139254 |
52. Bajaj JS, Kakiyama G, Zhao D, Takei H, Fagan A, Hylemon P, Zhou H, Pandak WM, Nittono H, Fiehn O, Salzman N, Holtz M, Simpson P, Gavis EA, Heuman DM, Liu R, Kang DJ, Sikaroodi M, Gillevet PM. Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis. Alcohol Clin Exp Res. 2017 Nov;41(11):1857-1865. |
53. Fawley J, Koehler S, Cabrera S, Lam V, Fredrich K, Hessner M, Salzman N, Gourlay D. Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine. J Surg Res. 2017 Oct;218:35-42. |
54. Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ. Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility. PLoS One. 2018;13(1):e0190351. PMCID: PMC5749787 |
55. Banla IL, Kommineni S, Hayward M, Rodrigues M, Palmer KL, Salzman NH, Kristich CJ. Modulators of Enterococcus faecalis Cell Envelope Integrity and Antimicrobial Resistance Influence Stable Colonization of the Mammalian Gastrointestinal Tract. Infect Immun. 2018 Jan;86(1). PMCID: PMC5736811 |
56. Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE. Response. FASEB J. 2012 Nov;26(11):4388-4389. |
57. Chang YL, Rossetti M, Vlamakis H, Casero D, Sunga G, Harre N, Miller S, Humphries R, Stappenbeck T, Simpson KW, Sartor RB, Wu G, Lewis J, Bushman F, McGovern DPB, Salzman N, Borneman J, Xavier R, Huttenhower C, Braun J. A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. Mucosal Immunol. 2019 Mar;12(2):457-467. PMCID: PMC6202286 |
58. Jeschke JC, Mayne CG, Ziegelbauer J, DeCiantis CL, Singh S, Kumar SN, Suchi M, Iwakura Y, Drobyski WR, Salzman NH, Williams CB. A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis. Mucosal Immunol. 2018 Jul;11(4):1127-1137. PMCID: PMC6571016 |
59. Kirkpatrick CL, Parsley NC, Bartges TE, Wing CE, Kommineni S, Kristich CJ, Salzman NH, Patrie SM, Hicks LM. Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. Microb Biotechnol. 2018 Sep;11(5):943-951. PMCID: PMC6116741 |
60. Grayson MH, Camarda LE, Hussain SA, Zemple SJ, Hayward M, Lam V, Hunter DA, Santoro JL, Rohlfing M, Cheung DS, Salzman NH. Intestinal Microbiota Disruption Reduces Regulatory T Cells and Increases Respiratory Viral Infection Mortality Through Increased IFNγ Production. Front Immunol. 2018;9:1587. PMCID: PMC6048222 |
61. Chakraborty R, Lam V, Kommineni S, Stromich J, Hayward M, Kristich CJ, Salzman NH. Ceftriaxone Administration Disrupts Intestinal Homeostasis, Mediating Noninflammatory Proliferation and Dissemination of Commensal Enterococci. Infect Immun. 2018 Dec;86(12). PMCID: PMC6246901 |
62. Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME. Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res. 2018 Oct 12;123(9):1091-1102. PMCID: PMC6205737 |
63. Banla LI, Salzman NH, Kristich CJ. Colonization of the mammalian intestinal tract by enterococci. Curr Opin Microbiol. 2019 Feb;47:26-31. PMCID: PMC6511500 |
64. Geldart KG, Kommineni S, Forbes M, Hayward M, Dunny GM, Salzman NH, Kaznessis YN. Engineered E. coli Nissle 1917 for the reduction of vancomycin-resistant <i>Enterococcus</i> in the intestinal tract. Bioeng Transl Med. 2018 Sep;3(3):197-208. PMCID: PMC6195901 |
65. Banla LI, Pickrum AM, Hayward M, Kristich CJ, Salzman NH. Sortase-Dependent Proteins Promote Gastrointestinal Colonization by Enterococci. Infect Immun. 2019 Mar;87(5). PMCID: PMC6479037 |
66. Bajaj JS, Salzman NH, Acharya C, Sterling RK, White MB, Gavis EA, Fagan A, Hayward M, Holtz ML, Matherly S, Lee H, Osman M, Siddiqui MS, Fuchs M, Puri P, Sikaroodi M, Gillevet PM. Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo-Controlled Trial. Hepatology. 2019 Nov;70(5):1690-1703. PMCID: PMC6819208 |
67. Dahlgren AF, Pan A, Lam V, Gouthro KC, Simpson PM, Salzman NH, Nghiem-Rao TH. Longitudinal changes in the gut microbiome of infants on total parenteral nutrition. Pediatr Res. 2019 Jul;86(1):107-114. PMCID: PMC6594895 |
68. Schwimmer JB, Johnson JS, Angeles JE, Behling C, Belt PH, Borecki I, Bross C, Durelle J, Goyal NP, Hamilton G, Holtz ML, Lavine JE, Mitreva M, Newton KP, Pan A, Simpson PM, Sirlin CB, Sodergren E, Tyagi R, Yates KP, Weinstock GM, Salzman NH. Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2019 Oct;157(4):1109-1122. PMCID: PMC6756995 |
69. Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 May 16;25(Suppl 2):S5-S12. |
70. Bajaj JS, Salzman N, Acharya C, Takei H, Kakiyama G, Fagan A, White MB, Gavis EA, Holtz ML, Hayward M, Nittono H, Hylemon PB, Cox IJ, Williams R, Taylor-Robinson SD, Sterling RK, Matherly SC, Fuchs M, Lee H, Puri P, Stravitz RT, Sanyal AJ, Ajayi L, Le Guennec A, Atkinson RA, Siddiqui MS, Luketic V, Pandak WM, Sikaroodi M, Gillevet PM. Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis. JCI Insight. 2019 Dec 19;4(24). PMCID: PMC6975263 |
71. Hofeld BC, Puppala VK, Tyagi S, Ahn KW, Anger A, Jia S, Salzman NH, Hessner MJ, Widlansky ME. Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation. Sci Rep. 2021 Feb 17;11(1):3972. PMCID: PMC7889883 |
72. Ta-Chiang Liu, Bhaskar Gurram, Megan Baldridge, Richard Head, Vy Lam, Chengwei Luo, Yumei Cao, Pippa Simpson, Michael Hayward, Mary Holtz, Joshua Noe, Diana Lerner, Jose Cabrera, Vincent Biank, Michael Stephens, Curtis Huttenhower, Dermot McGovern, Ramnik Xavier, Thaddeus Stappenbeck, Nita Salzman. O-011 Paneth Cell Phenotypes Define a Subtype of Pediatric Crohn's Disease Through Alterations in Host-Microbial Interactions Inflammatory Bowel Diseases. Inflammatory Bowel Diseases, Volume 22, Issue suppl_1, March 2016, Page S4,. |
73. Dokoshi T, Seidman JS, Cavagnero KJ, Li F, Liggins MC, Taylor BC, Olvera J, Knight R, Chang JT, Salzman NH, Gallo RL. Skin inflammation activates intestinal stromal fibroblasts and promotes colitis. J Clin Invest. 2021 Nov 01;131(21). PMCID: PMC8553570 |
74. Cabrera SM, Coren AT, Pant T, Ciecko AE, Jia S, Roethle MF, Simpson PM, Atkinson SN, Salzman NH, Chen YG, Hessner MJ. Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study. Sci Rep. 2022 Feb 28;12(1):3306. PMCID: PMC8885673 |
75. Zenga J, Atkinson S, Yen T, Massey B, Stadler M, Bruening J, Peppard W, Reuben M, Hayward M, Mesich B, Buchan B, Ledeboer N, Sanchez JL, Fraser R, Lin CW, Holtz ML, Awan M, Wong SJ, Puram SV, Salzman N. A phase 2 trial of a topical antiseptic bundle in head and neck cancer surgery: Effects on surgical site infection and the oral microbiome. EBioMedicine. 2022 Jul;81:104099. PMCID: PMC9168040 |
76. Wang LS, Kuo CT, Peiffer D, Seguin C, Stoner K, Huang YW, Huang THM, Salzman N, Liu Z, Rosenberg D, Yang GY, Yang W, Bi X, Carmella S, Hecht S, Stoner G. Anthocyanins, anthocyanin derivatives, and colorectal cancer Anthocyanins in Health and Disease. 1 January 2013:225-243. |
77. Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE. Response FASEB Journal. November 2012;26(11):4388-4389. |
78. Cais RE, Kometani JM, Salzman NH. NMR Characterization of the Chemical Microstructure of Vinylidene Halide and Vinyl Halide Copolymers Macromolecules. 1986;19(4):1006-1012. |
79. Cais RE, Kometani JM, Salzman NH. NMR CHARACTERIZATION OF THE CHEMICAL MICROSTRUCTURE OF VINYLIDENE HALIDE AND VINYL HALIDE COPOLYMERS. Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material. 1984;50:285-289. |
80. Gerrard DL, Coleman MM, Gordon B, Lehrle RS, McNeill IC, Cais RE, Kometani JM, Salzman NH. Annual chemical congress: Polymer analysis Analytical Proceedings. 1983;20(11):569-582. |
81. Wu X, Khatun A, Kasmani MY, Chen Y, Zheng S, Atkinson S, Nguyen C, Burns R, Taparowsky EJ, Salzman NH, Hand TW, Cui W. Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice. J Exp Med. 2022 Nov 07;219(11). PMCID: PMC9440727 |
82. Sargin P, Roethle MF, Jia S, Pant T, Ciecko AE, Atkinson SN, Salzman NH, Teng RJ, Chen YG, Cabrera SM, Hessner MJ. <i>Lactiplantibacillus plantarum</i> 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats. Gut Microbes. 2022;14(1):2136467. PMCID: PMC9586621 |
83. Frenn M, Salzman N, Lam V, Holtz M, Moosreiner A, Garnier-Villarreal M. <i>Retracted:</i> Body Mass Index and Gut Microbiome: A Cluster-Randomized, Controlled, Pilot Feasibility Study. Child Obes. 2023 Feb 02. |
84. Sadler KE, Atkinson SN, Ehlers VL, Waltz TB, Hayward M, Rodríguez García DM, Salzman NH, Stucky CL, Brandow AM. Gut microbiota and metabolites drive chronic sickle cell disease pain. bioRxiv. 2023 Apr 28. PMCID: PMC10168372 |
85. Fung C, Fraser LM, Barrón GM, Gologorsky MB, Atkinson SN, Gerrick ER, Hayward M, Ziegelbauer J, Li JA, Nico KF, Tyner MDW, DeSchepper LB, Pan A, Salzman NH, Howitt MR. Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape. Proc Natl Acad Sci U S A. 2023 Jun 06;120(23):e2216908120. PMCID: PMC10266004 |
86. Bora G, Atkinson SN, Pan A, Sood M, Salzman N, Karrento K. Impact of auricular percutaneous electrical nerve field stimulation on gut microbiome in adolescents with irritable bowel syndrome: A pilot study. J Dig Dis. 2023 May;24(5):348-358. |
87. Khatun A, Wu X, Qi F, Gai K, Kharel A, Kudek MR, Fraser L, Ceicko A, Kasmani MY, Majnik A, Burns R, Chen YG, Salzman N, Taparowsky EJ, Fang D, Williams CB, Cui W. BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology. Adv Sci (Weinh). 2023 Oct;10(28):e2206692. PMCID: PMC10558681 |
88. Ellison JS, Atkinson SN, Hayward M, Hokanson E, Sheridan KR, Salzman N. The intestinal microbiome of children with initial and recurrent nephrolithiasis: A pilot study and exploratory analysis. J Pediatr Urol. 2024 Feb;20(1):18-25. PMCID: PMC10922064 |
89. Yuan C, Rayasam A, Moe A, Hayward M, Wells C, Szabo A, Mackenzie A, Salzman N, Drobyski WR. Interleukin-9 production by type 2 innate lymphoid cells induces Paneth cell metaplasia and small intestinal remodeling. Nat Commun. 2023 Dec 02;14(1):7963. PMCID: PMC10693577 |
90. Hang Nghiem-Rao T, Johnson JS, Pan A, Atkinson SN, Behling C, Simpson PM, Holtz ML, Weinstock GM, Schwimmer JB, Salzman NH. A serum-induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):886-897. |
91. Dokoshi T, Chen Y, Cavagnero KJ, Rahman G, Hakim D, Brinton S, Schwarz H, Brown EA, O'Neill A, Nakamura Y, Li F, Salzman NH, Knight R, Gallo RL. Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice. Nat Commun. 2024 Apr 08;15(1):3009. PMCID: PMC11001995 |
92. Jennings KC, Johnson KE, Hayward MA, Kristich CJ, Salzman NH. CCR2-dependent CX3CR1+ colonic macrophages promote <i>Enterococcus faecalis</i> dissemination. Infect Immun. 2024 May 07;92(5):e0000624. PMCID: PMC11075457 |
Books, Chapters, and Reviews |
1. Bevins, C. L. and N. H. SALZMAN. 2011. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nature Reviews Microbiology, 9:356-368, Epub 2011 Mar 22. PMID: 21423246 |
2. SALZMAN, N. H. 2010. Microbiota-immune system interaction: an uneasy alliance. Curr Opin Microbiol Feb;14(1): 99-105. Epub 2010 Oct 21.PMID: 20971034 |
3. SALZMAN, N. H. and C. L. Bevins, 2008. Negative Interactions with the Microbiota (IBD). GI Microbiota and Regulation of the Immune System. G. Huffnagle and M. Noverr. Georgetown, TX, Landes Bioscience: 67-78. |
4. SALZMAN, N. H., M.A. Underwood, and C. L. Bevins, 2007. Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa. Seminars in Immunology 19:70-83. |
5. SALZMAN, N.H., and F.R. Maxfield. 1993. Quantitative Fluorescence Techniques for the Characterization of Endocytosis in Intact Cells. Subcellular Endocytic Components: Identification and Characterization, edited by .J. Bergeron and J.R. Harris. Plenum Press, NY. |
6. Salzman NH, Schwimmer JB. Pediatric nonalcoholic fatty liver disease and the microbiome: Mechanisms contributing to pathogenesis and progression. Curr Opin Endocr Metab Res. 2021 Aug;19:22-29. PMCID: PMC8248528 |
Editorials, Letters To Editor, Other |
1. SALZMAN, N. H. 2010. Paneth cell defensins and the regulation of the microbiome: Détente at mucosal surfaces. Gut Microbes, in press. |
2. SALZMAN, N. H. 2008. Defensins Versus Bacteria: Not Just Antibiotics Anymore. Gastroenterology 134(7): 2174-7. |
Abstracts |
1. Hung, K., C. L. Bevins, M. Barman, N.A. Bos, M. Stoel, E. Amir, P. Teggatz, M. Hayward, and N.H. SALZMAN. Paneth Cell Defensins in the Regulation of Intestinal Microbial Ecology: Implications for Infection and Inflammation. Antimicrobial Peptides Gordon Research Conference, Ventura, CA., March 2009. |
2. SALZMAN, N. H. Enteric Defensins are Essential Regulators of Intestinal Microbial Ecology. ASM Beneficial Microbes Conference, San Diego, CA., October 2008. |
3. SALZMAN, N. H. Enteric Defensins are Essential Regulators of Intestinal Microbial Ecology. SPR Research Conference, Houston, Tx., October 2007. |
4. Barman, M., D. Unold, K. Shifely, E. Amir, K. Hung, and N. H. SALZMAN. Enteric Salmonellosis Profoundly Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract. American Society for Microbiology, Toronto, May 2007. |
5. Dominguez, T., M. Eloi, A. Cheung, D. Carcamo-Molina, N. SALZMAN, and E. Porter. Salmonella induced apoptosis in small intestinal crypts: A possible novel virulence factor. American Society for Microbiology, Toronto, May 2007. |
6. Hung, K., E. Amir, C.L. Bevins, N. Bos, M. Stoel, and N.H. SALZMAN. Enteric Defensins are Essential Regulators of Intestinal Microbial Ecology. Antimicrobial Peptides Gordon Conference, Barga, Italy. May 2007 |
7. Hung, K., E. Amir, C.L. Bevins, N. Bos, M. Stoel, and N.H. SALZMAN. Enteric defensins and the regulation of the intestinal microbiota. Midwest Microbial Pathogenesis Conference, Cinncinati, OH, October 2006. |
8. Barman, M., D. Unold, K. Hung, and N. H. SALZMAN. Profound alterations of the intestinal microbiota are induced by enteric Salmonellosis. Midwest Microbial Pathogenesis Conference, Cinncinati, OH, October 2006. |
9. SALZMAN, N. H., N. Bos, G. Welling, H. Harmsen, Y. Paterson, and C. Bevins. Regulation of the Intestinal Microbiota by Paneth Cell Defensins. Digestive Disease Week, AGA, Poster of Distinction, Chicago, IL, May 2005 |
10. Wehkamp, J., N. H. SALZMAN, E. Porter, M. Weichenthal, R. E. Petras, B. Shen, E. Schaeffeler, M. Schwab, R. Linzmeier, R. W. Feathers, H. Chu, H. Lima, K. Fellermann, T. Ganz, E. F. Stange, and C. L. Bevins. Reduced Paneth cell -defensin expression in Crohn's Disease of the ileum. Digestive Disease Week, AGA, Poster of Distinction, Chicago, IL, May 2005 |
11. SALZMAN, N. H., D. Ghosh, K. Huttner, C. Bevins. Human Defensin 5 Transgenic Mice: An In Vivo Model of Defensin Function. Digestive Disease Week, AGA, Distinguished Plenary Presentation, San Francisco, CA, May 2002. |
12. SALZMAN, N.H., M. Chou, H. deJong, L. Liu, E. M. Porter, and Y. Paterson. Inhibition of Paneth cell antimicrobial peptide expression following Salmonella infection requires SPI1 type III secretion. Antimicrobial Peptides Gordon Conference, March 2001. |
13. DeJong, H., N. Bos, Y. Paterson, and SALZMAN, N.H.. Flow cytometric analysis of intestinal bacterial populations using in situ hybridization with 16S rRNA oligonucleotide probes. American Society for Microbiology, Annual Meeting, May 2000. |
14. SALZMAN, N.H., H. de Jong, C. Bevins, and Y. Paterson. Oral infection with S. typhimurium causes down-regulation of enteric antimicrobial peptide expression. Keystone Symposia on Molecular and Cellular Biology. Innate and Acquired Immunity at Mucosal Surfaces, January, 2000. |
15. SALZMAN, N.H., K. Huttner, Y. Paterson, and C. Bevins. A transgenic mouse model for investigatingthe role of HD5 in mucosal immunity. Antimicrobial Peptides Gordon Conference, April, 1999. |
16. SALZMAN, N.H., E. Mallow, A. Harris, J. Russell, R. DeBerardinis, E. Ruchelli, and C. Bevins. Developmental expression of human enteric defensins. United States and Canadian Academy of Pathology, Annual Meeting, March 1996. |
17. SALZMAN, N.H., R. A. Polin, M. C. Harris, E. Ruchelli, A. Hebra, S. Zirin-Butler, and C. Bevins. Increased enteric defensin expression in necrotizing enterocolitis. Society for Pediatric Research, Annual Meeting, May 1996. |
18. SALZMAN, N.H., C. Bevins, and K. Huttner. Paneth cell specific expression of human defensin-5 in transgenic mice. American Society for Microbiology, Annual Meeting, May, 1996. |
19. Maxfield, F.R., SALZMAN, N.H., K. Dunn, and T. McGraw. 1988. Mechanisms for sorting ligands and receptors following endocytosis. Protein Traffic in Parasites and Mammalian Cells. Edited by J.D. Lonsdale-Eccles and J.K. Lenahan. The International Laboratory for Research on Animal Diseases, Nairobi, Kenya. |
