Medical College of Wisconsin
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Pui Kei Wu PhD
Department of Biochemistry

Basic Science Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

Refereed Journal Publications/Original Papers
1. Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI. Mortalin (HSPA9) facilitates <i>BRAF</i>-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability. Sci Signal. 2020 Mar 10;13(622). PMCID: PMC7099430
2. Wu PK, Hong SK, Starenki D, Oshima K, Shao H, Gestwicki JE, Tsai S, Park JI. Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. Oncogene. 2020 May;39(21):4257-4270. PMCID: PMC7244387
3. Wu PK, Becker A, Park JI. Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway. Int J Mol Sci. 2020 Jul 30;21(15). PMCID: PMC7432891
4. Antholine WE, Vasquez-Vivar J, Quirk BJ, Whelan HT, Wu PK, Park JI, Myers CR. Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals. Int J Mol Sci. 2019 Mar 06;20(5). PMCID: PMC6429069
5. Wu PK, Hong SK, Park JI. Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in <i>KRAS</i> and <i>BRAF</i> Tumor Cells. Mol Cell Biol. 2017 Sep 15;37(18). PMCID: PMC5574043
6. Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI. A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. Mol Cell Biol. 2013 Oct;33(20):4051-67. PMCID: PMC3811686
7. Wu PK, Hong SK, Yoon SH, Park JI. Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. FEBS J. 2015 Mar;282(6):1017-30. PMCID: PMC4368470
8. Wu PK, Park JI. MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms. Semin Oncol. 2015 Dec;42(6):849-62. PMCID: PMC4663016
9. Hong SK, Starenki D, Wu PK, Park JI. Suppression of B-Raf<sup>V600E</sup> melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone. Cancer Biol Ther. 2017 02;18(2):106-114. PMCID: PMC5362989
10. Starenki D, Hong SK, Wu PK, Park JI. Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells. Cancer Biol Ther. 2017 Jul 03;18(7):473-483. PMCID: PMC5639831
11. Hong SK, Wu PK, Karkhanis M, Park JI. ERK1/2 can feedback-regulate cellular MEK1/2 levels. Cell Signal. 2015 Oct;27(10):1939-48. PMCID: PMC4540659
12. Hong SK, Wu PK, Park JI. A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses. Cell Signal. 2018 Jan;42:11-20. PMCID: PMC5732048
13. Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI. Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. Exp Cell Res. 2014 Oct 01;327(2):340-52. PMCID: PMC4164593
14. Wu PK, Tai WC, Choi RC, Tsim KW, Zhou H, Liu X, Jiang ZH, Hsiao WL. Chemical and DNA authentication of taste variants of Gynostemma pentaphyllum herbal tea. Food Chem. 2011 Sep 01;128(1):70-80.
15. Wu PK, Chi Shing Tai W, Liang ZT, Zhao ZZ, Hsiao WL. Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. Life Sci. 2009 Jul 17;85(3-4):113-21.
16. Ha WY, Wu PK, Kok TW, Leung KW, Mak NK, Yue PY, Ngai SM, Tsai SN, Wong RN. Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. Int J Biochem Cell Biol. 2006;38(8):1393-401.
17. Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45.
18. Wang TY, Zhou H, Wong YF, Wu PK, Hsiao WL, Leung EL, Liu L. The Predicted Proteomic Network Associated with the Antiarthritic Action of Qingfu Guanjieshu in Collagen-II-Induced Arthritis in Rats. Evid Based Complement Alternat Med. 2013;2013:582493. PMCID: PMC3678439
19. Hsiao WLW, Tai WCS, Mo Z, Wu PK. Anticancer activities and the drug targets of botanical saponins from a medicinal herb, gynostemma pentaphyllum Journal of Acupuncture and Tuina Science. October 2008;6(5):271-272.

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