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CURRICULUM VITAE

Ranjan K. Dash PhD
Professor
Department of Biomedical Engineering

OFFICE ADDRESS:
Translational and Biomedical Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-955-4497
Fax: 414-955-6546
Email: rdash@mcw.edu

EDUCATION:
07/1985 - 06/1988 BSc, Mathematics, Utkal University, Bhubaneswar, Orissa, India
07/1988 - 06/1991 MSc, Mathematics, Utkal University, Bhubaneswar, Orissa, Inida
12/1992 - 07/1998 PhD, Theoretical Cardiovascular Fluid Dynamics, Indian Institute of Technology, New Delhi, India
Thesis title: Theoretical Studies of Cardiovascular Flows in Small and Large Blood Vessels

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
12/1992 - 12/1994 Junior Research Fellow and Teaching Assistant, Department of Mathematics, Indian Institute of Technology, New Delhi, India
12/1994 - 07/1998 Senior Research Fellow and Teaching Assistant, Department of Mathematics, Indian Institute of Technology, New Delhi, India
01/1996 - 07/1998 Research Project Scientist, Department of Mathematics, Indian Institute of Technology, New Delhi, India
09/1998 - 07/2000 Postdoctoral Research Associate, Department of Mathematics, Texas A&M University, College Station, TX
10/2000 - 11/2002 Postdoctoral Senior Fellow, National Simulation Resource for Circulatory Mass Transport and Exchange, Department of Bioengineering, University of Washington, Seattle, WA
12/2002 - 08/2003 Postdoctoral Senior Fellow, Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, WA
09/2003 - 05/2006 Senior Research Associate, Center for Modeling Integrated Metabolic Systems (MIMS), Departments of Pediatrics and Biomedical Engineering, Case Western Reserve University, Cleveland, OH

FACULTY APPOINTMENTS:
06/2006 - 06/2010 Assistant Professor, Department of Physiology and Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI
07/2010 - 06/2016 Associate Professor, Department of Physiology and Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI
11/2013 - 06/2016 Adjunct Associate Professor, Department of Biomedical Engineering, Marquette University, Milwaukee, WI
07/2016 - 06/2018 Associate Professor (Secondary), Department of Physiology, Medical College of Wisconsin, Milwaukee, WI
07/2016 - 06/2018 Associate Professor (Primary) & Co-Director of Graduate Studies, Joint Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, WI
08/2016 - 07/2018 Adjunct Associate Professor, Department of Biomedical Engineering, University of Wisconsin - Milwaukee, Milwaukee, WI
07/2018 - Present Professor (Secondary), Department of Physiology, Medical College of Wisconsin, Milwaukee, WI
07/2018 - Present Professor (Primary) & Co-Director of Graduate Studies, Joint Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, WI
08/2018 - Present Adjunct Professor, Department of Biomedical Engineering, University of Wisconsin - Milwaukee, Milwaukee, WI

AWARDS AND HONORS:
06/1988 Graduated BSc in First Class Honors and Distinction, Utkal University, Bhubaneswar, Orissa, India
06/1991 Graduated MSc in First Class and 4th Rank (81%), Utkal University, Bhubaneswar, Orissa, India
12/1991 Qualified National Eligibility Test for Junior Research Fellowship conducted jointly by Council of Scientific and Industrial Research and University Grant Commission, Government of India
12/1992 - 12/1993 Secured a high 9.7 CGPA on 10-point scale from 25 credits in pre-PhD course work, Indian Institute of Technology, New Delhi, India
12/1992 - 12/1994 Junior Research Fellowship, University Grant Commission, Government of India
12/1994 - 12/1997 Senior Research Fellowship, University Grant Commission, Government of India
01/1996 - 07/1998 Research Scientist on a sponsored project “Flow through Pipes and Channels with Variable Cross Sections” (PI: Girija Jayaraman) from the Department of Science and Technology, Government of India
07/2007 - 06/2011 Scientific Development Grant ($260,000/4 Years), American Heart Association (National Affiliate)
09/2011 Founding Faculty, Virtual Physiological Rat Center (an NIH-funded National Center for Systems Biology) and Center for Computational Medicine, Medical College of Wisconsin
2011 Who's Who in Science and Engineering, Marquis
08/2015 Outstanding Faculty Service Award for service to the Library Committee from July 2014 to June 2015, Medical College of Wisconsin
12/2017 Dean's Choice Outstanding Graduate School Educator Award for commitment to excellence in graduate education during the academic year '16/'17, Graduate School of Biomedical Sciences, Medical College of Wisconsin
07/2018 Award of Tenure for distinction in scholarly and intellectual achievements, Joint Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin
2020 Dean's Choice Outstanding Graduate School Educator Award for commitment to excellence in graduate education during the academic year '19/'20, Graduate School of Biomedical Sciences, Medical College of Wisconsin
06/2024 Outstanding Faculty Service Award for service to the University Rank and Tenure Committee from July 2021 to June 2024, Medical College of Wisconsin

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
01/2002 - Present Biomedical Engineering Society (Professional Member)
10/2008 - Present Biophysical Society (Professional Member)
10/2008 - Present American Physiological Society (Professional Member affiliation with the Cardiovascular Section)
10/2011 - Present American Heart Association (Professional Member affiliation with the Council on Basic Cardiovascular Sciences)
10/2016 - Present IEEE Engineering in Medicine & Biology Society (Professional Member)
01/2024 - Present International Society for Computational Biology (Professional Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
04/2009 - Present IEEE EMBS Conference Proceedings (Topics include Systems Biology; Bioinformatics and Computational Biology; and Modeling Methodologies.)
03/2011 - Present Systems Biology, Frontiers Journals (Frontiers in Physiology; Frontiers in Applied Mathematics and Statistics)
05/2014 - Present Cardiovascular Genetics and Systems Medicine, Frontiers in Cardiovascular Medicine
03/2021 - Present Computational Physiology and Medicine, Frontiers in Physiology
Editorial Board
08/2010 - Present Bioenergetics: Open Access, Hilaris Publisher
10/2010 - Present Journal of Bioengineering and Biomedical Science, OMICS Group
Journal Review
11/2017 - Present Contributing Faculty Member of F1000Prime, Integrative Physiology Section of F1000 Physiology
Annals of Biomedical Engineering
American Journal of Physiology: Heart and Circulation Physiology
Cellular and Molecular Bioengineering
American Journal of Physiology: Endocrinology and Metabolism
Journal of Applied Physiology
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Biochimica and Biophysica Acta: Bioenergetics
Biochimica and Biophysica Acta: Molecular Cell Research
Theoretical Biology and Medical Modeling
Journal of Biological Chemistry
Mathematical and Computer Modeling
Physica-A
PLoS One
IET Systems Biology
Journal of Royal Society Interface
Acta Biotheoretica
Acta Mechanica
BMC Physiology
BMC Biophysics
Nitric Oxide
IMA Journal of Mathematical Medicine and Biology
Journal of Physiology - London
Free Radical Biology and Medicine
BMC Systems Biology
Cardiovascular Engineering and Technology
Biochimica and Biophysica Acta: Biomembranes
Physica-D
Cell Biophysics & Biochemistry
Biochimica et Biophysica Acta: General Subject
Chemical Science
Journal of Applied Fluid Mechanics
Bioscience Report
Computational Biology & Chemistry
Mathematical Problems in Engineering
Mathematical Biosciences
European Journal of Pharmacology
Computers in Biology and Medicine
Biophysical Journal
Biomedical Engineering Online
American Journal of Physiology: Cell Physiology
PLoS Computational Biology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
06/2006 - Present Member, Recruitment Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
06/2006 - 06/2016 Member, Planning Committee, Biotechnology and Bioengineering Center, Medical College of Wisconsin
06/2006 - Present Member, Planning Committee, Center for Computational Medicine & Virtual Physiological Rat Center, Medical College of Wisconsin
10/2006 - 12/2006 Review Panel Member, Inducement Grant Program for Faculty Collaborations, Biotechnology and Bioengineering Center, Medical College of Wisconsin
09/2007 - 07/2012 Member, PhD Dissertation Committee for Mathew Thompson, advised by Dr. Daniel Beard, Department of Physiology, Medical College of Wisconsin
09/2007 - 07/2010 Member, MS Dissertation Committee for Anthony Rick, advised by Dr. Daniel Beard, Department of Physiology, Medical College of Wisconsin
07/2011 - 09/2011 Review Panel Member, Research Grant Program for Postdoctoral and Clinical Fellows within the Medical College of Wisconsin, Innovation Center, Biotechnology & Bioengineering Center, Medical College of Wisconsin
09/2013 - Present Member, CTSI Pilot and Collaborative Clinical and Translational Research Program, Multi-institutional Study Panel, Greater Milwaukee Area
11/2013 - 02/2019 Co-Advisor, PhD Dissertation Committee for Xiao Zhang, advised by Dr. Said Audi, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
05/2014 - 06/2016 Member, Faculty Experience, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
07/2014 - 06/2020 Member with Distinction, Library Committee, Faculty Council, Medical College of Wisconsin
07/2016 - Present Faculty Mentor, Program for Undergraduate Research Experience, Medical College of Wisconsin
07/2016 - Present Faculty Mentor, Summer Program for Undergraduate Research, Medical College of Wisconsin
07/2016 - Present Faculty Mentor, Diversity Summer Health-Related Research & Education Program, Graduate School of Biomedical Sciences, Medical College of Wisconsin
07/2016 - Present Member, Graduate Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
10/2016 - 04/2017 Co-Developer, PhD Program Handbook and Proposal, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
12/2016 - 05/2017 Member, Faculty Search Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
01/2017 - Present Member, Faculty Interview/Recruitment Committee, University of Wisconsin - Milwaukee, Department of Biomedical Engineering
07/2017 - 12/2018 Co-Director, Joint MU-MCW PhD Program, Medical College of Wisconsin School of Biomedical Sciences
07/2017 - Present Member with Distinction, Graduate Studies Council, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering; Graduate School of Biomedical Sciences, Medical College of Wisconsin
09/2017 - 07/2023 Director/Advisor, PhD Dissertation Committee for Shima Sadri, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2017 - 05/2018 Member, MS Dissertation Committee Member for Nina Friedly, advised by Dr. Said Audi, Department of Biomedical Engineering, Marquette University
09/2017 - 10/2019 Member, MS Dissertation Committee for Anthony Cammarata, advised by Dr. Said Audi, Department of Biomedical Engineering, Marquette University
01/2018 - 03/2018 Study Panel Member, Digestive Disease Center Pilot Grant Review Committee, Medical College of Wisconsin
07/2018 - Present Mentoring Committee Member, MCW Medical Student Training Program (MSTP), Medical College of Wisconsin
09/2018 - 06/2020 Director/Advisor, MS Dissertation Committee of Viren Shah, Department of Biomedical Engineering, University of Wisconsin - Milwaukee
09/2018 - 06/2024 Member, PhD Dissertation Committee Member of Mir Hadi, advised by Dr. Amit Joshi, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
11/2018 - 06/2021 BME Faculty Representative, Department Mentoring Champions Committee of Faculty Affairs, Medical College of Wisconsin
01/2019 - Present Co-Director, MU-MCW Joint Department of Biomedical Engineering Ph.D. Program, Medical College of Wisconsin Graduate School of Biomedical Sciences
03/2019 - 06/2019 Study Panel Member, Cardiovascular Center Pilot Grant Review Committee, Medical College of Wisconsin
07/2019 - 09/2019 Member, Faculty Search Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
07/2019 - Present Member, Promotion and Tenure Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2019 - Present Member/Co-Advisor, PhD Dissertation Committee Member for Taheri Pardis, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2019 - Present Director/Advisor, PhD Dissertation Committee of Justin Womack, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2019 - 08/2020 Member, PhD Dissertation Committee of Choi Hoon, advised by Dr. Yoganandan Narayan, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
03/2020 - 08/2020 Member, Faculty Search Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
06/2020 - Present Co-Advisor, MSTP/PhD Dissertation Committee of Chris Monti, advised by Dr. Scott Terhune, Department of Microbiology and Immunology, Medical College of Wisconsin
07/2020 - 06/2021 Co-Developer, MS and ME Program Proposals and Handbooks, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2020 - Present Member, PhD Dissertation Committee of Patrick Noffke, advised by Dr. Janette Strasburger, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2020 - 08/2021 Member, MS Dissertation Committee of Sweta Ganesh, advised by Dr. Said Audi, Department of Biomedical Engineering, Marquette University
09/2020 - Present Director/Advisor, PhD Dissertation Committee of Viren Shah, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2020 - Present Member, Admission Committee, Medical Training Student Program, Medical College of Wisconsin
01/2021 - Present Member, Clinical Immersion Certification Program Development Committee, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
07/2021 - Present Member, University Rank and Tenure Committee, Medical College of Wisconsin
01/2022 - 12/2022 Departmental and Institutional Alignment Committee Member, MCW Promotion and Tenure Process and Equity Committee, Medical College of Wisconsin
01/2022 - 06/2024 Member, PhD Dissertation Committee of Tyler Rook, advised by Dr. Narayan Yoganandan, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
08/2023 - Present Director/Advisor, PhD Dissertation Committee of Yisak Asefa, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
09/2023 Member, MCW-led Seed Grants Peer Review Committee, Advancing Healthier Wisconsin Endowment
03/2024 - 07/2024 Member, Faculty Search Committee, Medical College of Wisconsin
04/2024 Member, BME Product Development Pilot Grant Review Panel, Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering
Member, Course Evaluation Committee, Graduate Studies Council, Medical College of Wisconsin

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
05/2010 - Present Member, Grant Reviewing Committee, Special Emphasis Study Panel ZHL1 CSR-G (S1) for RFA-HL-10-017 "Functional Modeling of Pediatric Upper Airway Disorders (R01)", Center for Scientific Review, National Institutes of Health
03/2012 - 03/2016 Member, Grant Reviewing Committee, Bioengineering and Basic Science Study Panel; Vascular Biology, Cardiac Mechanics, Bioengineering, American Heart Association
06/2012 - 10/2013 Member, Grant Reviewing Committee, Special Emphasis Study Panel ZEB1 OSR-C (O1) for MSM PAR-11-203 "Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (Interagency U01)", Center for Scientific Review, National Institutes of Health
07/2015 - Present Member, Grant Reviewing Committee, Special Emphasis Study Panel ZRG1 BST-T (O2) for Bioengineering Sciences and Technologies, Center for Scientific Review, National Institutes of Health
11/2017 - Present Invited External Reviewer, Faculty Promotion Review Committee, Candidacy of Dr. Rachael Hageman Blair for promotion from Assistant Professor to Associate Professor with Tenure, Department of Biostatistics, State University of New York - Buffalo
11/2019 - Present Co-Chair, Grant Reviewing Committee, Fellowship Bioengineering and Basic Science Peer Review Panel; Vascular Biology, Cardiac Mechanics, Bioengineering, American Heart Association
2019 - Present Co-Chair, Grant Reviewing Committee, AHA Fellowship Engineering and Technology Peer Review Panel, American Heart Association
07/2020 - Present Member, Grant Reviewing Committee, Special Emphasis Study Panel ZRG1 CVRS A05, Cardiovascular Respiratory Sciences, Center for Scientific Review, American Heart Association
03/2023 Reviewer, ORAU Ralph E. Powe Junior Faculty Enhancement Awards Program Committee, Oak Ridge Associated Universities, USA
09/2023 Reviewer, Grant Reviewing Committee, Scientific Peer Advisory and Review Services (SPARS) division of the American Institutes of Biological Sciences (AIBS), Nebraska Established Program to Stimulate Competitive Research (EPSCoR)

INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
04/2008 Invited International Reviewer, International PhD Dissertation Review Committee, "The Effect of Chaotic Vasomotion in Skeletal Muscle on Tissue Oxygenation" by Mr. Ranjan K. Pradhan, Department of Electrical Engineering, Indian Institute of Technology, Chennai, India
04/2012 Invited External Reviewer, International Faculty Promotion Review Committee for candidacy for promotion for Dr. Ponakala Nagarani from Lecturer to Senior Lecturer, Department of Mathematics, University of West Indies, Mona Campus, Jamaica, West Indies
08/2016 Invited International Reviewer, International PhD Dissertation Review Committee: "Enhanced 1D Modeling for Predicting BID-DO Conditions in River" by Ms. Ritu Kapoor, Department of Mathematics, Banasthali University, Uttar Pradesh, India
01/2018 Invited International Reviewer, International PhD Dissertation Review Committee: "Some Mathematical Models of Flow in Renal Tubules and Solute Transfer in Glomerular Capillaries" by a graduate student of Dr. P. Muthu, Department of Mathematics, National Institute of Technology, Warangal, Telangana, India
10/2018 International Reviewer, International Grant Review Committee: Computational Modeling grant focusing on cellular metabolism and tumor progression, Netherlands Organization for Scientific Research, Earth Life Sciences Division
01/2019 Invited International Reviewer, International Grant Review Committee: "Role of Ultrastructural Alterations in Diabetic Cardiomyopathy" by Mr. Shouryadipta Ghosh, Department of Biomedical Engineering, University of Melbourne, Australia
10/2019 International Reviewer, International Grant Review Committee: Computational Modeling Grant focusing on cellular metabolism using a telecommunication approach, National Science Centre of Poland
12/2020 Reviewer, International Grant Review Committee, Computational Biofluid Dynamics Grant, National Foundation of Science, Higher Education and Technological Development, Republic of Croatia
05/2021 International Reviewer, International Grant Review Committee: Grant focusing on mitochondrial role in Parkinson’s disease, UK Medical Research Council
03/2022 Invited International Reviewer, International PhD Dissertation Review Committee: "Study of Nonlinear Wave Propagation in Compressible Flow” of Ms. Nishi Deepa Palo, Dept. of Mathematics, Netaji Subhas Institute of Technology, University of Delhi, India
04/2022 International Reviewer, International Grant Review Committee: Grant focusing on mitochondrial Ca2+ regulation and metabolism, German Research Foundation
02/2023 Invited International Reviewer, International PhD Dissertation Review Committee: "Unravelling the Role of DNA Methylation in the Pathology of Cardiac Ischemia Reperfusion Injury and its Management” of Ms. Sri Rahavi B, Sastra Deemed University, Tamil Nadu, India
03/2023 International Reviewer, International Grant Review Committee: Computational Biology grant focusing on machine learning and artificial intelligence for developing diagnostic decision support for fetal monitoring systems, National Science Centre of Poland
09/2023 International Reviewer, International Grant Review Committee: Computational fluid dynamics grant focusing on the influence of venous anatomy on local hemodynamics in patients with deep vein thrombosis of the lower limb, National Science Centre of Poland

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Medical Scientist Training Program (MSTP)
Source:
NIH/NIGMS (T32-GM080202-15)
Role & Effort:
Participating Faculty Mentor
PI:
Nita Salzman and Joseph Barbieri, Department of Microbiology & Immunology, Medical College of Wisconsin
Dates:
07/01/2010 - 06/30/2025
Direct Funds:
$3,500,000 (for current 5 years period)
  
Title:
Integrated Physiology Training: Molecule to Organism
Source:
NIH/NHLBI (T32-HL007852-26)
Role & Effort:
Participating Faculty Mentor
PI:
Matthew Hodges, Department of Physiology, Medical College of Wisconsin
Dates:
07/01/2013 - 06/30/2028
Direct Funds:
$2,000,000 (for current 5 years period)
  
Title:
Experimental and Computational Analysis of Mechanisms of Mitochondrial-Cellular ROS Crosstalk in the Kidney in Salt-Sentsitive Hypertension
Source:
NIH/NHLBI (R01-Hl151587)
Role & Effort:
Principal Investigator/Program Director (Current Efforts 25%)
PI:
Allen Cowley, Department of Physiology, Medical College of Wisconsin
Dates:
01/01/2021 - 12/31/2024
Direct Funds:
$1,560,000 (for 4 years, with $780,000/4 years for Dash)
  
Title:
Medical Student Summer Research Training Program (MSSRTP)
Source:
NIH/NHLBI (T35-HL072483-39)
Role & Effort:
Participating Faculty Mentor
PI:
Ramani Ramchandran, Departments of Pediatrics, Medical College of Wisconsin
Dates:
07/01/2021 - 06/30/2026
Direct Funds:
$1,000,000 (for current 5 year period)
  
Title:
DMS/NIGMS 1: Collaborative Research: Advanced Ion Channel Modeling and Computational Tool with Application to Voltage Dependent Anion Channel and Mitochondrial Model Development
Source:
NSF/DMS (2153387)
Role & Effort:
Principal Investigator
PI:
Ranjan Dash
Dates:
07/15/2022 - 06/30/2025
Direct Funds:
$385,000 (≈$192,500 for 3 years for Dash)
  
Title:
Computational Simulations of Network Dynamics and Response in CART Therapy
Source:
MCW Cancer Center
Role & Effort:
Sponsor/Mentor/Advisor along with Dr. Scott Terhune
PI:
Viren Shah (Graduate Student of Drs. Dash and Terhune)
Dates:
07/01/2023 - 06/30/2025
Direct Funds:
$70,000 (graduate fellowship for 2 years)
  
Title:
Experimental and Computational Assessment of the Role of NOX4 in Mitochondrial Dysfunction Associated with ARDS
Source:
NIH/NHLBI (R15-HL129209-03)
Role & Effort:
Co-Investigator
PI:
Said Audi, MU-MCW Joint Department of Biomedical Engineering
Dates:
07/01/2023 - 06/30/2025
Direct Funds:
$300,000 (for 2 years; Salary support for Dash based on efforts)
  
Title:
Developing the Next Line of Single-Cell Workflows to More Accurately Interrogate and Model TCR-T and CAR-T Cell Behavior to Improve Prognostic Biomarkers for Cancer
Source:
Phenome X (FP00024536)
Role & Effort:
Co-Investigator
PI:
Anthony Zamora, Department of Medicine, Medical College of Wisconsin
Dates:
07/01/2023 - 06/30/2025
Direct Funds:
$216,470 (for 2 years; Salary support for Dash and a graduate student)
  
Title:
Identify a New Non-Canonical Role of MEF2D⍺2 Protein Isoform in Skeletal Muscle Metabolism
Source:
NIH/NIAMS (R21-AR083158-01)
Role & Effort:
Co-Investigator (PI of MCW subcontract)
PI:
Ravi Singh, University of Houston
Dates:
07/01/2023 - 05/31/2025
Direct Funds:
$275,000 (for 2 years, Salary support for Dash based on efforts)
  
Title:
Bottom-up and Top-down Computational Modeling Approaches to Study CMV Retinitis
Source:
NIH/NIAID (F30-AI179084-01)
Role & Effort:
Co-Sponsor/Mentor/Advisor along with Dr. Scott Terhune
PI:
Christopher Monti (MD/PhD Graduate Student of Drs. Dash and Terhune)
Dates:
07/01/2023 - 06/30/2027
Direct Funds:
$210,776 (for 4 years; includes graduate fellowship + tuition)
  
Title:
Data-Driven Computational Modeling of Cellular Response in CART Therapy
Source:
MCW/AHW (FP00025793)
Role & Effort:
Principal Investigator
PI:
Ranjan Dash
Dates:
01/01/2024 - 12/31/2024
Direct Funds:
$50,000 (1 year; Dr. Schott Terhune is Co-Investigator)
  
Title:
Effects of Salt Loading upon Renal Energy Production, Oxidative Stress, and Injury
Source:
AHA (24CDA1273496)
Role & Effort:
Co-Sponsor/Mentor/Advisor
PI:
Satoshi Shimada, Department of Physiology, Medical College of Wisconsin
Dates:
07/01/2027 - 06/30/2024
Direct Funds:
$231,000 (for 3 years)
  
Prior
Peer Review
Title:
Center for Modeling Integrated Metabolic Systems
Source:
NIH/NIGMS (P50-GM066309)
Role & Effort:
Co-Investigator (9/2003 – 5/2006)
PI:
Gerald Saidel, Case Western Reserve University
Dates:
07/01/2002 - 06/30/2007
Direct Funds:
$2,000,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Integrated Modeling of Cardiac Metabolism and Transport
Source:
NIH/NHLBI (R01-HL072011)
Role & Effort:
Co-Investigator (6/1/2006 – 8/31/2013)
PI:
Daniel Beard, UMich, Ann Arbor
Dates:
12/01/2002 - 06/30/2017
Direct Funds:
$250,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Analysis of Large-Scale Biochemical Systems
Source:
NIH/NIGMS (R01-GM068610)
Role & Effort:
Co-Investigator (6/1/2006 – 7/31/2008)
PI:
Daniel Beard, Medical College of Wisconsin
Dates:
08/01/2004 - 07/31/2008
Direct Funds:
$250,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Multi-Scale Modeling of the Heart in Cardiovascular Disease and Metabolic Syndrome
Source:
NIH/NIBIB (R01-EB005825)
Role & Effort:
Co-Investigator (6/1/2006 – 7/31/2008)
PI:
Daniel Beard, Medical College of Wisconsin
Dates:
08/01/2005 - 07/31/2008
Direct Funds:
$250,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Time Course of Metabolic Adaptations during Loading and Unloading
Source:
NASA Johnson Space Center (NNJ06HD81G)
Role & Effort:
Co-Principal Investigator (PI of MCW Subaward)
PI:
Marco Cabrera, Case Western Reserve University
Dates:
06/12/2006 - 06/11/2009
Direct Funds:
$35,280 (MCW Subaward for 2 years)
  
Title:
Computational Modeling of Mitochondrial Energetics
Source:
AHA National (SDG-0735093N)
Role & Effort:
Principal Investigator/Program Director
PI:
Ranjan Dash
Dates:
07/01/2007 - 06/30/2011
Direct Funds:
$260,000 (4 years)
  
Title:
PPG: Anesthetic-Induced Cardiac Preconditioning (Project II: Mitochondrial Function in Anesthetic-Induced Cardiac Preconditioning)
Source:
NIH/NIGMS (P01-GM066730)
Role & Effort:
Co-Investigator (8/1/2008 – 7/31/2013)
PI:
Zeljko Bosnjak, Medical College of Wisconsin
Dates:
08/01/2008 - 07/31/2013
Direct Funds:
$1,250,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Mechanisms of Metabolic Dysfunction in Heart Disease
Source:
NIH/NHLBI (R01-HL094317)
Role & Effort:
Co-Investigator
PI:
Daniel Beard, Medical College of Wisconsin
Dates:
01/01/2009 - 12/31/2012
Direct Funds:
$225,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Inflammation and Infection in Acquired and Congenital Cardiovascular Disease
Source:
NIH/NHLBI (T32-HL094273)
Role & Effort:
Participating Faculty Mentor for Jason Bazil (9/2010 – 8/2013)
PI:
Andrew Greene, Medical College of Wisconsin
Dates:
05/01/2009 - 04/30/2014
Direct Funds:
$100,000 (Per year; No salary support for faculty)
  
Title:
Database-Enabled Tools for Regulatory Metabolic Networks
Source:
NSF Biological Database and Informatics (DBI-0743705)
Role & Effort:
Co-Principal Investigator (PI of MCW Subaward)
PI:
Meral Ozsoyoglu, Case Western Reserve University
Dates:
08/01/2009 - 07/31/2012
Direct Funds:
$51,589 (MCW Subaward for 3 years)
  
Title:
Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Hearts
Source:
NIH/NHLBI (R01-HL095122)
Role & Effort:
Principal Investigator/Program Director
PI:
Ranjan Dash, Medical College of Wisconsin; Amadou Camara, Department of Anesthesiology, Medical College of Wisconsin
Dates:
04/01/2010 - 03/31/2015
Direct Funds:
$1,400,000 ($700,000 for Dash)
  
Title:
Virtual Physiological Rat Project
Source:
NIH/NIGMS (P50-GM094503)
Role & Effort:
Co-Investigator
PI:
Daniel Beard, UMich, Ann Arbor
Dates:
08/11/2011 - 06/30/2016
Direct Funds:
$13,000,000 (Salary support for Dash based on efforts)
  
Title:
Mechanisms of Metabolic Dysfunction in Type-2 Diabetes
Source:
NIH/NIDDK (R01-DK095210)
Role & Effort:
Co-Investigator (4/1/2012 – 8/31/2013)
PI:
Daniel Beard, UMich - Ann Arbor; Robert Wiseman, MSU - East Lansing
Dates:
04/01/2012 - 03/31/2017
Direct Funds:
$420,000 (Per year; Salary support for Dash based on efforts)
  
Title:
Mechanistic Characterization of Calcium and ROS Induced Mitochondrial Dysfunction
Source:
NIH/NHLBI (K99/R00-HL121160)
Role & Effort:
Co-Mentor/Co-Advisor (no salary support)
PI:
Jason Bazil, Assistant Professor of Physiology, MSU-East Lansing
Dates:
09/16/2014 - 01/31/2019
Direct Funds:
$714,511 (for 5 years)
  
Title:
PPG: Mechanisms of Anesthetics Cardioprotection (Project III: Modeling of Mitochondria and Cell Function in Anesthetic Cardioprotection)
Source:
NIH/NIGMS (P01-GM066730)
Role & Effort:
Principal Investigator of Project III
PI:
Zeljko Bosnjak (Project I and overall); Mingyu Liang (Project III); Ranjan Dash (Project III); Xiaowen Bai (Stem Cell Core)
Dates:
03/01/2015 - 02/29/2021
Direct Funds:
$5,830,000 ($1,375,000 for Project III (5 years))
  
Title:
Analyzing the Cardiac Power Grid: Adaptive Responses to Fluctuating Local Demand
Source:
NIH/NHLBI (U01-HL122199)
Role & Effort:
Principal Investigator of MCW Subcontract
PI:
James Bassingthwaighte, UW Seattle; Ranjan Dash, MCW; Daniel Beard, UMich; Andrew McCulloch, UCSD
Dates:
09/15/2015 - 05/31/2021
Direct Funds:
$2,150,000 (240,000 for MCW Subcontract (5 years))
  
Title:
Systems Biology Based Tools for Modeling Platelet Storage Lesion for Optimal Blood Transfusions
Source:
US Army (DOD)-CFDRC SBIR Phase II Project (W81XWH-16-C-0106)
Role & Effort:
Principal Investigator of MCW Subcontract
PI:
Andrzej Przekwas and Mahadevabharath Somayaii (CRDRC); Ranjan Dash (MCW); Anand Ramasubramanian (SJSU)
Dates:
09/26/2016 - 01/25/2019
Direct Funds:
$58,442 (for MCW subcontract (2 years))
  
Title:
Predictive Computational Modeling to Define Antiviral Efficacy
Source:
MCW Advancing a Healthier Wisconsin Endowment (REP # 5520429)
Role & Effort:
Co-Principal Investigator
PI:
Scott Terhune, Microbiology and Immunology, Medical College of Wisconsin; Ranjan Dash, Medical College of Wisconsin
Dates:
02/01/2017 - 01/31/2019
Direct Funds:
$200,000 (for 2 years with $100,000 for 2 years for Dash)
  
Title:
SPECT Imaging and Computational Modeling for Assessment of Acute Lung Injury
Source:
NIH/NHLBI (R15-HL129209)
Role & Effort:
Co-Investigator (Current efforts 3%)
PI:
Said Audi, MU-MCW Joint Department of Biomedical Engineering; Elizabeth Jacobs, Department of Pulmonary Medicine, Medical College of Wisconsin
Dates:
01/01/2019 - 12/31/2020
Direct Funds:
$300,000 (Salary support for Dash; 3% effort)
  
Title:
Predictive Computational Modeling to Define Antiviral Efficacy
Source:
NIH/NIAID (R21-AI149039)
Role & Effort:
Principal Investigator
PI:
Scott Terhune, Microbiology and Immunology, Medical College of Wisconsin; Ranjan Dash
Dates:
03/18/2020 - 02/28/2022
Direct Funds:
$275,000 (137,200 for Dash (2 years))
  
Title:
BioModME – A Web Application for Biosystem Modeling Made Easy
Source:
MCW/BME (FP00022381)
Role & Effort:
Principal Investigator
PI:
Ranjan Dash
Dates:
06/01/2022 - 05/31/2023
Direct Funds:
$50,000
  
Title:
Development of a Novel Assay for Quantifying Tissue Antioxidant Status in Donated Organs
Source:
MCW/BME (FP00024456)
Role & Effort:
Co-Investigator
PI:
Said Audi, MU-MCW Joint Department of Biomedical Engineering
Dates:
07/01/2023 - 06/30/2024
Direct Funds:
$50,000 (1 year; Salary support for Dash based on efforts)
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
Dash RK, "A numerical study of pulsatile blood flow in an eccentric catheterized artery using a fast algorithm.", Department of Mathematics Seminar, Indian Institute of Technology, Kharagpur, India, 08/16/2002
Dash RK, "Molecular modeling of NADPH oxidase 2 assembly, activation, and ROS production.", 2017 Cardiac Physiome Meeting, Toronto, Canada, 11/06/2017 - 11/09/2017
 
National
Dash RK, "Computational modeling of oxygen and carbon dioxide transport and exchange in the physiological systems", Department of Applied Science, College of William & Mary, Williamsburg, VA, 10/24/2002
Dash RK, "Estimation of muscle oxygen uptake during muscle contraction and recovery using deconvolution.", Special Session on Microvascular Oxygen Exchange, Biomedical Engineering Society Annual Meeting, Nashville, TN, 10/01/2003 - 10/04/2003
Dash RK, "Cellular metabolic dynamics in skeletal muscle during ischemia – In silico studies using a multi-scale top-down integrated model", Fifth World Congress of Nonlinear Analysis, Orlando, FL, 07/02/2008 - 07/09/2008
Dash RK, "Modeling regulation of mitochondrial free Ca2+ by ATP/ADP-dependent Ca2+ buffering.", Special Session on Oxidative Phosphorylation and Mitochondrial Metabolism, Biophysical Society Annual Meeting, Boston, MA, 02/28/2009 - 03/04/2009
Dash RK, "Regulation of pyruvate dehydrogenase in skeletal muscle during altered energy demand; Inference from computational analysis of phosphoenergetics data from 31P-NMRS.", National Centers for Systems Biology Annual Meeting, Chicago, IL, 07/17/2012 - 07/18/2012
Dash RK, "Towards a quantitative understanding of the etiology of cardiac ischemia-reperfusion injury: Prospective and progress", Video presentation via the web for the Synthetic and Systems Biology Group, North Carolina State University, Raleigh, NC, 05/30/2014
Dash RK, "Towards a quantitative understanding of the etiology of cardiac ischemia-reperfusion injury: Role of mitochondrial Ca2+-ROS crosstalk", Department of Physiology Seminar, University of Arizona, Tucson, AZ, 11/12/2014
Dash RK, "Multi-scale computational modeling of cardiac ischemia-reperfusion injury phenotype: Role of mitochondrial Ca2+-ROS crosstalk", Modeling and Computation Seminar, Program in Applied Mathematics, University of Arizona, Tucson, AZ, 11/13/2014
Dash RK, "Modeling the detailed kinetics and nitric oxide inhibition of mitochondrial cytochrome c oxidase.", Special Platform Session on Metabolic Models, Biomedical Engineering Society Annual Meeting, Minneapolis, MN, 10/05/2016 - 10/08/2016
Dash RK, “Computational Modeling to Solve the Mystery of Complex Biological Functions and Regulations”, Quantitative Systems Pharmacology (QSP) Symposium, Buffalo, NY, 07/26/2023
 
Local
Dash RK, "Numerical study of flow in a catheterized curved artery with stenosis", National Simulation Resource for Circulatory Mass Transport and Exchange Seminar, Department of Bioengineering, University of Washington, Seattle, WA, 10/02/2000
Dash RK, "Computational modeling of oxygen and carbon dioxide transport and exchange in the physiological systems", Resource Facility for Population Kinetics Seminar, Department of Bioengineering, University of Washington, Seattle, WA, 09/25/2002
Dash RK, "Application of constraint-based estimation methods to complex metabolic systems", MIMS Center Summer Workshop on Modeling Metabolic Dynamics, Case Western Reserve University, Cleveland, OH, 06/11/2004
Dash RK, "Application of large-scale computational methods to complex metabolic system models", MIMS Center Advisory Board Meeting, Case Western Reserve University, Cleveland, OH, 10/22/2004
Dash RK, "A model of oxidative phosphorylation in mammalian skeletal muscle (Korzeniewski and Zoladz, Biophys Chem 92:17-34, 2001)", MIMS Center Journal Club, Case Western Reserve University, Cleveland, OH, 02/25/2005
Dash RK, "Control of respiration and bioenergetics during muscle contraction (Chung et al, Am J Physiol Cell Physiol 288:730-738, 2005)", MIMS Center Journal Club, Case Western Reserve University, Cleveland, OH, 04/29/2005
Dash RK, "Skeletal muscle energy metabolism: modeling and experimental validation", MIMS Center Review, Case Western Reserve University, Cleveland, OH, 07/22/2005
Dash RK, "Cellular metabolic dynamics in skeletal muscle during ischemia – In silico studies", Biotechnology and Bioengineering Center Journal Club, Medical College of Wisconsin, Milwaukee, WI, 06/28/2006
Dash RK, "Mechanism-oriented computational modeling of mitochondrial bioenergetics and cation handling", Department of Physiology Seminar, Medical College of Wisconsin, Milwaukee, WI, 10/13/2009
Dash RK, Bazil JN, "Towards reevaluating mitochondrial Ca2+ dynamics", Mentor-Mentee Seminar, Biotechnology Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, 05/03/2011
Dash RK, "Roles of cations and ROS in the dynamic regulation of mitochondrial function in normal and ischemic hearts", Faculty spotlight presentation, Biotechnology Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, 09/20/2011
Dash RK, "Regulation of pyruvate dehydrogenase in skeletal muscle during altered energy demand: In-ference from computational analysis of phosphoenergetics data from 31P-NMRS", VPR Project Advisory Board Meeting, Milwaukee, WI, 07/26/2012 - 07/27/2012
Dash RK, "Computational analyses of mitochondrial and cellular function in anesthetic-induced cardiac preconditioning", Department of Anesthesiology PPG Project III Presentation, Medical College of Wisconsin, Milwaukee, WI, 11/28/2012
Dash RK, "Regulation of mitochondrial energy metabolism in cardiac and skeletal muscle during altered energy expenditure: role of pyruvate dehydrogenase", Department of Physiology Seminar, Medical College of Wisconsin, Milwaukee, WI, 03/06/2013
Dash RK, Pannala VR, "Mechanisms of the mitochondrial glutathione ROS scavenging systems", Mentor-Mentee Seminar, Biotechnology Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, 05/03/2013
Dash RK, "Solving the Mystery of Ca2+ handling in cardiac mitochondria", UWM-MCW Joint Bioengineering Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 03/28/2014
Dash RK, "Integrated modeling of cardiac mitochondrial Ca2+-ROS handling and redox signaling in oxidative stress.", MCW Redox Biology Program Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 08/06/2015
Dash RK, "Modeling the mystery of mitochondrial Ca2+-ROS interplay and dysregulation in cardiac IR injury.", Department of Physiology Seminar, Medical College of Wisconsin, Milwaukee, WI, 04/13/2016
Dash RK, "PPG Project III: Modeling mitochondrial and cellular functions in anesthetic cardioprotection.", PPG Site Visit by Dr. Shey-Shing Sheu's, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 05/12/2016
Dash RK, "Probing cellular mechanisms through computational modeling.", MU-MCW-UWM Joint Biomedical Engineering Seminar Series, Medical College of Wisconsin, Milwaukee, WI, 04/14/2017
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
International
Dash RK, Jayaraman G, and Mehta KN, "Estimation of increased wall shear stress during coronary angioplasty – a theoretical model", 23rd National Conference on Fluid Mechanics and Fluid Power, Bhopal, India, 12/27/1996 - 12/29/1996
 
National
Dash RK and Daripa P, "A new class of models and their study for bi-directional propagation of capillary-gravity water waves", 36th Annual Meeting of the Society of Engineering Science, University of Texas, Austin, TX, 10/25/1999 - 10/27/1999
Dash RK and Daripa P, "A new class of model equations for two-way propagation of capillary-gravity water waves", 52nd Annual Meeting of the American Physical Society, Division of Fluid Dynamics, New Orleans, LA, 11/21/1999 - 11/23/1999
Dash RK, Bell BM, Kushmerick MJ, and Vicini P, "Estimation of muscle oxygen uptake during muscle contraction and recovery using deconvolution", Special Session on Micro-vascular Oxygen Exchange, Biomedical Engineering Society Annual Meeting, Nashville, TN, 10/01/2003 - 10/04/2003
Dash RK, Cellular metabolic dynamics in skeletal muscle during ischemia - in silico studies using multi-scale top-down integrated model., Fifth World Congress of Nonlinear Analysis (WCNA 2008), Orlando, FL, 07/02/2008 - 07/09/2008
Dash RK, Thompson MD, Vinnakota KC, Haumann J, Aldakkak M, Camara AKS, Stowe DF, and Beard DA, "Modeling regulation of mitochondrial free Ca2+ by ATP/ADP-dependent Ca2+ buffering", Special Session on Oxidative Phosphorylation and Mitochondrial Metabolism, Biophysical Society Meeting, Boston, MA, 02/28/2009 - 03/04/2009
Dash RK, Modeling the detailed kinetics and nitric oxide inhibition of mitochondrial cytochrome c oxidase., Special Platform Session on Metabolic Models, Biomedical Engineering Society Annual Meeting, Minneapolis, MN, 10/05/2016 - 10/08/2016
 

MCW TEACHING ACTIVITIES:
Graduate Student Education
09/2007 - 12/2007 Developed and taught (Course Co-Director) along with Dr. Daniel Beard a part of a three-credit systems biology course (50% of the course, spanning 14 weeks, totaling 28 1.5-hrs lectures) “PHYS8275, Special Topics in Physiology: Chemical Biophysics of Cellular Processes.”
09/2009 - 12/2009 Developed and taught (Course Co-Director) along with Dr. Daniel Beard a part of a three-credit systems biology course (50% of the course, spanning 14 weeks, totaling 28 1.5-hrs lectures) “PHYS8284, Special Topics in Physiology: Computational Methods in Biomedical Research.”
09/2011 - 12/2011 Developed and taught (Course Co-Director) along with Drs. Daniel Beard and Brian Carlson a part of a one-credit course (33% of the course, spanning 14 weeks, totaling 14 1-hr sessions) “PHYS8275, Special Topics in Physiology: Classic Papers in Physiology Research.”
01/2016 - 04/2016 Taught one 1.5-hrs lecture as a Guest Lecturer on “Multi-Scale and Systems Modeling of Cardiac Energy Metabolism and Ca2+-ROS Handling in Health and Disease” as a part of graduate course “BIEN5720, Cardiopulmonary Mechanics” (Instructor: Dr. John LaDisa).
01/2016 - 04/2016 Taught two 2-hrs lectures as a Guest Lecturer on “Introduction to Computational Modeling of Biological/Physiological Systems” as a part of a multi-disciplinary graduate course “PHYS8230, Physiological Genomics” (Course Director: Dr. Mingyu Liang).
01/2017 - 04/2017 Taught two 2-hrs lectures as a Guest Lecturer on “Introduction to Computational Modeling of Biological/Physiological Systems” as a part of a multi-disciplinary graduate course “PHYS8230, Physiological Genomics” (Course Director: Dr. Mingyu Liang).
01/2018 - 04/2018 Developed and taught (Course Co-Director) along with Dr. Said Audi a part of a three-credit systems biology course (>50% of the course, spanning 14 weeks, totaling 28 1.5-hrs lectures) “BIEN6391, Special Topics in BME: Modeling and Simulations of Integrated Cellular Systems” to the BME graduate students at the Medical College of Wisconsin and Marquette University.
09/2019 - 12/2019 Taught two 1.5-hrs lectures as a Guest Lecturer on “Introduction to Modeling and Simulations of Integrated Biological Systems” as a part of a BME graduate course “BIEN6710, Special Topics in BME: Cellular and Molecular Bioengineering” (Course Director: Dr. Brian Hoffmann) for the BME graduate students at the Medical College of Wisconsin and Marquette University.
01/2021 - 04/2021 Developed and taught (Course Co-Director) along with Dr. Said Audi a part of a three-credit systems biology course (>50% of the course, spanning 14 weeks, totaling 28 1.5-hrs lectures) “BIEN6391, Special Topics in BME: Modeling and Simulations of Integrated Cellular Systems” to the BME graduate students at the Medical College of Wisconsin and Marquette University.
09/2021 - 05/2022 BIEN8995: Independent Study in BME (1. Electrophysiological Computational Modeling for Patrick Noffke in Fall 2021 and Spring 2022, and 2. Topics in Mathematical Biology: Computational Virology for Christopher Monti in Fall 2021). Guided the students through the course materials focusing on mathematical modeling aspects.
 

EXTRAMURAL TEACHING:
Graduate Student Education
09/2001 - 12/2001 University of Washington, Taught a part of a bioengineering graduate course BIOEN589 (Bioengineering Principles of Physiology) floated by Dr. James Bassingthwaighte at the University of Washington; Developed two computational teaching models for the course which were used in laboratory classes for computational simulations; These were (1) a model for computing oxygen and carbon dioxide saturations of hemoglobin under varying physiological conditions and for computing oxygen and carbon dioxide contents in the whole blood, and (2) a four-compartmental recirculating model for transport and exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ions between the lungs and systemic circulation.
09/2002 - 12/2002 University of Washington, Taught a part of a bioengineering graduate course BIOEN589 (Bioengineering Principles of Physiology) floated by Dr. James Bassingthwaighte at the University of Washington; Developed two computational teaching models for the course which were used in laboratory classes for computational simulations; These were (1) a model for computing oxygen and carbon dioxide saturations of hemoglobin under varying physiological conditions and for computing oxygen and carbon dioxide contents in the whole blood, and (2) a four-compartmental recirculating model for transport and exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ions between the lungs and systemic circulation.
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
06/2006 - 08/2006 Aleksandra Polosukhina, Supervisor and Mentor, Medical College of Wisconsin
06/2006 - 08/2006 Victoria Georgakas, Supervisor and Mentor, Medical College of Wisconsin
05/2017 - 07/2017 Brittany Sheahan, Supervisor and Mentor, Medical College of Wisconsin
05/2018 - 07/2018 Jeannette Ingabire, Supervisor and Mentor, Medical College of Wisconsin
05/2019 - 07/2019 Janelle Lanham, Supervisor and Mentor, Medical College of Wisconsin
05/2021 - 07/2021 Grace Gibson, Supervisor and Mentor, Medical College of Wisconsin
 
Medical Students
07/2012 David Schauder, Supervisor and Mentor, Medical College of Wisconsin
07/2013 Amin Benanian, Supervisor and Mentor, Medical College of Wisconsin
 
Graduate Students
PhD Committees
08/2007 - 07/2012 Matthew Thompson, "Physiologically-based Pharmacokinetic Modeling of Drug Transport and Metabolism", Medical College of Wisconsin
MS Committees
08/2007 - 07/2010 Anthony Rick, "Identification of the Catalytic Mechanism of Mitochondrial Malate Dehydrogenase", Medical College of Wisconsin
PhD Students Advised
07/2020 - 05/2024 Chris Monti, Problems of computational virology (viral DNA replication and viral class protein synthesis, Medical College of Wisconsin
 
Postdoctoral Researchers
08/2007 - 06/2009 Johan Haumann, Supervisor, Mentor, Medical College of Wisconsin
01/2008 - 08/2013 Kalyan Vinnakota, PhD, Supervisor, Mentor and Co-Sponsor, Medical College of Wisconsin
08/2008 - 09/2013 Ranjan Pradhan, PhD, Supervisor, Mentor and Sponsor, Medical College of Wisconsin
03/2009 - 04/2015 Bhawana Agarwal, PhD, Supervisor, Mentor and Sponsor, Medical College of Wisconsin
03/2009 - 02/2011 Age Boelens, Mentor, Medical College of Wisconsin
09/2010 - 08/2013 Jason Bazil, PhD, Supervisor, Mentor and Sponsor, Medical College of Wisconsin
11/2010 - 09/2013 Christoph Blomeyer, Mentor, Medical College of Wisconsin
02/2012 - 11/2013 Shivendra Tewari, PhD, Supervisor, Mentor and Sponsor, Medical College of Wisconsin
07/2012 - 04/2016 Venkat Pannala, PhD, Supervisor, Mentor and Sponsor, Medical College of Wisconsin
06/2015 - 06/2018 Neeraj Manhas, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
04/2016 - 07/2022 Namrata Tomar, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
12/2016 - 06/2019 Yongwoon Jung, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
09/2017 - 09/2019 Sunil Kandel, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
04/2019 - 08/2021 Xiao Zhang, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
07/2020 - Present Satoshi Shimada, Mentor, Medical College of Wisconsin
02/2022 - Present Devanshi Dave, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
01/2024 - Present Sri Rahavi Boovarahan, Supervisor, Mentor, Sponsor, Medical College of Wisconsin
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
06/2004 - 08/2004 Jessica Ferrato, Supervisor and Mentor, Case Western Reserve University
06/2004 - 08/2004 Krisanne Litinas, Supervisor and Mentor, Case Western Reserve University
06/2005 - 08/2005 Eric Xu, Supervisor and Mentor, Case Western Reserve University
 
Graduate Students
PhD Students Advised
09/2003 - 05/2006 Haiying Zhou, "Whole-Body Gas Exchange and Acid-Base Balance during Hypoxia and Exercise", Case Western Reserve University
09/2003 - 05/2006 Yanjun Li, "Regulation of Cellular Metabolism and Energetics in Skeletal Muscle during Ischemia and Exercise", Case Western Reserve University
09/2003 - 05/2006 Jaeyeon Kim, "Regulation of Whole-Body Energy Metabolism and Fuel Homeostasis during Exercise., Case Western Reserve University
09/2017 - 08/2023 Shima Sadri, Computational modeling of mitochondrial bioenergetics and ROS homeostasis to quantitatively characterize underlying kinetic mechanisms of mitochondrial dysfunction and ROS dysregulation in the kidney in salt-sensitive hypertension., Marquette University and the Medical College of Wisconsin
09/2019 - Present Taheri Pardis, Multi-scale computational modeling of lung tissue bioenergetics to quantitatively characterize cellular and mitochondrial targets in acute lung injury (ALI) and acquired respiratory distress syndrome (ARDS), Marquette University and the Medical College of Wisconsin
09/2019 - Present Justin Womack, Problems of computational virology (cell cycle dysregulation with viral infection), Marquette University and the Medical College of Wisconsin
09/2020 - Present Viren Shah, Problems of Computational Immunology, Marquette University and the Medical College of Wisconsin
09/2023 - Present Yisak Asefa, Problems in computational modeling, focusing on mitochondrial metabolism in the heart and kidney, Marquette University and the Medical College of Wisconsin
PhD Committees
11/2013 - 03/2019 Xiao Zhang, "Multi-scale computational modeling of lung tissue bioenergetics to quantitatively characterize cellular and mitochondrial targets in acute lung injury and acquired respiratory distress syndrom", Marquette University
01/2022 - 06/2024 Tyler Rook, Marquette University and the Medical College of Wisconsin
MS Students Advised
09/2018 - 06/2020 Viren Shah, Computational modeling of mitochondrial bioenergetics with altered VDAC kinetics for ions and metabolites, University of Wisconsin - Milwaukee
04/2023 - 07/2023 Krisna Parab, Sastra University, India
 
Postdoctoral Researchers
09/2015 - 12/2023 Ben Korman, BSc, MBBS, MD, FFARACS, FANZCA, Advisor, University of Western Australia, Perth, Australia
 

PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Faculty
Graduate Courses and Teaching Activities (various)
Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering Ph.D. Program
 
Research Programs
Research Program Development (additional Information Available upon request)
 
 
 

CONFERENCE ABSTRACT REVIEWING AND POSTER JUDGING:
2015 - 2016 Abstract Reviewer, Proceedings of the Annual Biomedical Engineering Society Meetings (approx. 20-25 abstracts/yr during summer); Poster Presentation Judge (approx. 8-10 posters/yr), Annual Biomedical Engineering Society Meetings
2020 Abstract Reviewer, Proceedings of the Society of Free Radicals in Biology and Medicine (SFRBM) Meetings (approx. 20-25 abstracts/yr during fall)

FACULTY AFFILIATIONS WITH MCW RESEARCH CENTERS:
06/2006 - 06/2016 Biotechnology and Bioengineering Center, directed by Andrew Greene
09/2011 - 08/2013 Center for Computational Medicine and Virtual Physiological Rat Center, directed by Daniel Beard.
12/2014 - Present Cardiovascular Research Center, directed by Ivor Benjamin
12/2015 - Present Center of Systems Molecular Medicine, directed by Mingyu Liang

MISCELLANEOUS MCW SERVICES:
06/2006 - Present Miscellaneous services include, but are not limited to, (1) Participating and contributing to departmental activities; (2) Promoting the computational biology research program with visiting scientists; (3) Promoting the mission of the Institution, participating departments and Centers; (4) Judging MCW Research Day and graduate/medical students' poster presentations.

OTHER TEACHING ACTIVITIES:
12/1992 - 07/1998 Teaching and tutoring of Calculus I and II, Complex Analysis, Numerical Analysis, Ordinary Differential Equations, Initial and Boundary Value Problems, and Applied Mathematical and Computational Methods at Indian Institute of Technology, New Dehli as Teaching Assistant
06/2006 - Present Working closely with graduate students and postdoctoral fellows associated with computational biology research. Providing general consultations on specific aspects of mathematical modeling an computer simulations of transport and reaction processes in complex metabolic systems. Involved in educating, supervising, and mentoring or undergraduate and high school students interested in computational biology research.

WORKSHOPS/SYMPOSIUMS/CONFERENCE SESSIONS ORGANIZING/CHAIRING:
2007 Co-organized and co-chaired with Dr. Dexuan Xie (University of Wisconsin - Milwaukee) a special oral session on "High Performance Computing for Biological Modeling and Simulations" at the 7th International Conference on Computational and Mathematical Methods in Science and Engineering (CMMSE-2007), Chicago, June 20-23, 2007
2013 Organizing Committee Member of the 2013 and 2017 Cardiac Physiome Society Annual Meeting held in Bar Harbor, Maine, USA (Oct 2013).
2016 Chaired (Co-chair: Stacey Finley, University of Southern California) a platform session on "Metabolic Models," 2016 Biomedical Engineering Society Annual Meeting, Minneapolis, Oct 5-8, 2016
2016 Chaired (Co-chair: Said Audi, Marquette University) a platform session on "Computational Modeling in Cardiovascular Systems I," 2016 Biomedical Engineering Society Annual Meeting, Minneapolis, Oct 5-8, 2016.
2017 Organizing Committee Member of the 2013 and 2017 Cardiac Physiome Society Annual Meeting held in Toronto, Canada (November 2017).


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Dash RK, Jayaraman G, and Mehta KN. Estimation of increased flow resistance in a narrow catheterized artery - a theoretical model. J Biomech 29(7): 917-930, 1996.
2. Dash RK, Jayaraman G, and Mehta KN. Estimation of increased wall shear stress during coronary angioplasty - a theoretical model. Proceedings of the 23rd National Conference on Fluid Mechanics and Fluid Power, Bhopal, India, Dec 27-29, 1996 (pp. 522-533). (Shortlisted for Dr. M. G. Deshpande Memorial Prize for best paper; judged as the 2nd best paper.)
3. Dash RK, Mehta KN, and Jayaraman G. Casson fluid flow in a pipe filled with a homogeneous porous medium. Int J Eng Sci 34(10): 1145-1156, 1996.
4. Dash RK, Mehta KN, and Jayaraman G. Effect of yield stress on the flow of a Casson fluid in a homogeneous porous medium bounded by a circular tube. Appl Sci Res 57(1): 133-149, 1997.
5. Dash RK, Jayaraman G, and Mehta KN. Flow in a catheterized curved artery with stenosis. J Biomech 32(1): 49-61, 1999.
6. Daripa P and Dash RK. Relevance of the sixth-order Boussinesq equation for water waves. Proceedings of IMACS International Conference on Scientific Computing and Mathematical Modeling, University of Wisconsin, Milwaukee, May 25-27, 2000 (pp. 347-351).
7. Daripa P and Dash RK. Studies of capillary ripples in a sixth-order Boussinesq equation arising in water waves. Proceedings of the 5th International Conference on Mathematical and Numerical Aspects of Wave Propagation, Santiago de Compostela, Spain, July 10-14, 2000 (pp. 285-289).
8. Daripa P and Dash RK. A fast algorithm and its application to computing pulsatile flow in an eccentric catheterized artery. Proceedings of the International Conference on Recent Advances in Mathematical Sciences and Symposium on Challenges in Mathematical Sciences in the New Millennium, IIT Kharagpur, India, Dec 20-22, 2000 (pp. 379-390).
9. Dash RK, Jayaraman G, and Mehta KN. Shear augmented dispersion of a solute in a Casson fluid flowing in a conduit. Ann Biomed Eng 28(4): 373-385, 2000.
10. Jayaraman G and Dash RK. Numerical study of flow in a constricted curved annulus: an application to flow in a catheterized artery. J Eng Math 40(4): 355-376, 2001.
11. Daripa P and Dash RK. Weakly non-local solitary wave solutions of a singularly perturbed Boussinesq equation. Math Comp Simul 55: 393-405, 2001.
12. Dash RK and Daripa P. Analytical and numerical studies of a singularly perturbed Boussinesq equation. Appl Math Comput 126(1): 1-30, 2002.
13. Daripa P and Dash RK. A numerical study of pulsatile blood flow in an eccentric catheterized artery using a fast algorithm. J Eng Math 42(1): 1-22, 2002.
14. Daripa P and Dash RK. A class of model equations for bi-directional propagation of capillary-gravity waves. Int J Eng Sci 41(2): 201-218, 2003.
15. Daripa P and Dash RK. On a class of Boussinesq equations for shallow water waves. Lect Notes Comp Sci 2668: 764-773, 2003.
16. Dash RK and Bassingthwaighte JB. Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. Ann Biomed Eng 32(12): 1676-1693, 2004.
17. Dash RK, Bell BM, Kushmerick MJ, and Vicini P. Estimating in vitro mitochondrial oxygen consumption during muscle contraction and recovery: a novel approach that accounts for diffusion. Ann Biomed Eng 33(3): 343-355, 2005.
18. Calvetti D, Dash RK, Somersalo E, and Cabrera ME. Local regularization method applied to estimating oxygen consumption during muscle activities. Inverse Problems 22: 229-243, 2006.
19. Dash RK and Bassingthwaighte JB. Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate and hydrogen ion. Ann Biomed Eng 34(7): 1129-1148, 2006.
20. Lai N, Dash RK, Nasca MM, Saidel GM, and Cabrera ME. Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in-vivo & in-silico studies. Eur J Appl Physiol 97: 380-394, 2006.
21. Dash RK, Somersalo E, Cabrera ME, and Calvetti D. An efficient deconvolution algorithm for estimating oxygen consumption during muscle activities. Comput Meth Prog Biomed 85(3): 247-256, 2007.
22. Lai N, Camesasca M, Saidel GM, Dash RK, and Cabrera ME. Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise. Ann Biomed Eng 35(6): 956-969, 2007.
23. Dash RK, Dibella II JA, and Cabrera ME. A Computational model of skeletal muscle metabolism linking cellular adaptations induced by altered loading states to metabolic responses during exercise. Biomed Eng Online 6:14, 2007.
24. Carlson BE, Anderson JC, Raymond GM, Dash RK, and Bassingthwaighte JB. Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system. Adv Exp Med Biol 614: 353-360, 2008.
25. Dash RK, Li Y, Kim J, Saidel GM, and Cabrera ME. Modeling cellular metabolism and energetics in skeletal muscle: large-scale parameter estimation and sensitivity analysis. IEEE Trans Biomed Eng 55(4): 1298-1318, 2008.
26. Dash RK and Beard DA. Analysis of cardiac mitochondrial Na+/Ca2+ exchanger kinetics with a biophysical model of mitochondrial Ca2+ handling suggests a 3:1 stoichiometry. J Physiol 586(13): 3267-3285, 2008.
27. Dash RK, Li Y, Kim J, Beard DA, Saidel GM, and Cabrera ME. Metabolic dynamics in skeletal muscle during acute reduction in blood flow and oxygen supply to mitochondria - In silico studies using a multi-scale, top-down integrated model. PLoS One 3(9): e3168, 2008.
28. Li Y#, Dash RK#, Kim J, Saidel GM, and Cabrera ME. Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise - In silico studies. Am J Physiol Cell Physiol 296(1): C25-46, 2009. [# Equal contributions]
29. Dash RK, Qi F, and Beard DA. A biophysically-based mathematical model for the kinetics of mitochondrial calcium uniporter. Biophys J 96(4): 1318-1332, 2009.
30. Vanlier J, Wu F, Qi F, Vinnakota KC, Han Y, Dash RK, Yang F, and Beard DA. BISEN: Biochemical Simulation Environment. Bioinformatics 25(6): 836-837, 2009.
31. Qi F, Dash RK, Han Y, and Beard DA. Generating rate equations for complex enzyme systems by a computer-assisted systematic method. BMC Bioinformatics 10: 238, 2009.
32. Vinnakota KC, Beard DA, and Dash RK. Design of experiments for identification of complex biochemical systems with applications to mitochondrial bioenergetics. Proceedings of the IEEE Engineering in Medicine and Biology Society Conference, Minneapolis, Sept 2-6, 2009 (pp. 4171-4174).
33. Xie D, Dash RK, and Beard DA. An improved algorithm and its parallel implementation for solving a general blood-tissue transport and metabolism model. J Comp Phys 228(20): 7850-7861, 2009.
34. Dash RK and Bassingthwaighte JB. Erratum to: Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. Ann Biomed Eng 38(4): 1683-1701, 2010. [Republication of the entire article from Ann Biomed Eng 32(12): 1676-1693, 2004.]
35. Pradhan RK, Beard DA, and Dash RK. A biophysically-based mathematical model for the kinetics of mitochondrial Na+-Ca2+ antiporter. Biophys J 98(2): 218-230, 2010.
36. Li X, Dash RK, Pradhan RK, Qi F, Thompson M, Vinnakota KC, Wu F, Yang F, and Beard DA. A database of thermodynamic quantities for the reactions of glycolysis and the tricarboxylic acid cycle. J Phys Chem B 114(49): 16068-16082, 2010.
37. Chen X, Qi F, Dash RK, and Beard DA. Kinetics and regulation of mammalian NADH-ubiquinone oxidoreductase (Complex I). Biophys J 99(5): 1426-1436, 2010.
38. Haumann J#, Dash RK#, Stowe DF, Boelens AD, Beard DA, and Camara AKS. Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: Exploration of mechanisms. Biophys J 99(4): 997-1006, 2010. [# Equal contributions]
39. Pradhan RK, Qi F, Beard DA, and Dash RK. Characterization of membrane potential dependency of mitochondrial Ca2+ uptake by an improved biophysical model of mitochondrial Ca2+ uniporter. PLoS One 5(10):e13278, 2010.
40. Bazil JN and Dash RK. A minimal model for the mitochondrial rapid mode of Ca2+ uptake mechanism. PLoS One 6(6):e21324, 2011.
41. Vinnakota KC, Dash RK, and Beard DA. Stimulatory effects of calcium on respiration and NAD(P)H synthesis in intact rat heart mitochondria utilizing physiological substrates cannot explain respiratory control in vivo. J Biol Chem 286(35): 30816-30822, 2011.
42. Qi F, Pradhan RK, Dash RK, and Beard DA. Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase. BMC Biochem 12:53, 2011.
43. Pradhan RK, Qi F, Beard DA, and Dash RK. Characterization of Mg2+ inhibition of mitochon-drial Ca2+ uptake by a mechanistic model of mitochondrial Ca2+ uniporter. Biophys J 101(9): 2071-2081, 2011.
44. Agarwal B, Camara AKS, Stowe DF, Bosnjak ZJ, and Dash RK. Enhanced charge-independent mitochondrial free Ca2+ and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection. Biochim Biophys Acta Bioenerg 1817(3): 453-465, 2012.
45. Coskun SA, Qi X, Cakmak A, Cheng E, Cicek EA, Yang L, Jadeja R, Dash RK, Lai N, Ozsoyoglu G, and Ozsoyoglu ZM. PathCase-SB: Integrating data sources and providing tools for systems biology research. BMC Syst Biol 6(1):67, 2012.
46. Qi X, Coskun SA, Cakmak A, Cheng E, Cicek EA, Yang L, Jadeja R, Syed S, Dash RK, Lai N, Ozsoyoglu G, and Ozsoyoglu ZM. PathCase-SB: Database-enabled tools for regulatory metabolic networks. Newsletter of the ACM SIGBioinformatics 2(3): 16-25, 2012.
47. Tewari SG, Dash RK, Beard DA, and Bazil JN. A biophysical model of the mitochondrial ATP-Mg/Pi carrier. Biophys J 103(7): 1616-1625, 2012.
48. Aldakkak M, Stowe DF, Dash RK, and Camara AKS. Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. Free Radic Biol Med 56: 193-202, 2013.
49. Bazil JN, Blomeyer CA, Pradhan RK, Camara AKS, and Dash RK. Modeling the calcium sequestration system in isolated guinea pig cardiac mitochondria. J Bioenerg Biomembr 45(3): 177-188, 2013.
50. Blomeyer CA, Bazil JN, Stowe DF, Pradhan RK, Dash RK, and Camara AKS. Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr 45(3): 189-202, 2013.
51. Boelens AD, Pradhan RK, Blomeyer C, Camara AKS, Dash RK, and Stowe DF. Extra-matrix Mg2+ limits Ca2+ uptake and modulates Ca2+ uptake-independent respiration and redox state in cardiac isolated mitochondria. J Bioenerg Biomembr 45(3): 203-218, 2013.
52. Coskun SA, Cicek AE, Lai N, Dash RK, Ozsoyoglu ZM, and Ozsoyoglu G. An online model composition tool for systems biology models. BMC Syst Biol 7(1): 88, 2013.
53. Pannala VR, Bazil JN, Camara AKS, and Dash RK. A Biophysically-based mathematical model for the catalytic mechanism of glutathione reductase. Free Radic Biol Med 65: 1385-1397, 2013.
54. Menzies RI, Unwin RJ, Dash RK, Beard DA, Cowley AW, Carlson BE, Mullins JJ, and Bailey MA. Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats. Front Physiol 4: 305, 2013.
55. Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ, and Camara AKS. Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. Biochim Biophys Acta Bioenerg 1837(3): 354-365, 2014.
56. Pannala VR, Bazil JN, Camara AKS, and Dash RK. A mechanistic mathematical model for the catalytic action of glutathione peroxidase. Free Radic Res 48(4): 487-502, 2014.
57. Tewari SG, Camara AKS, Stowe DF, and Dash RK. Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake. J Physiol 592(9): 1917-1930, 2014.
58. Bassingthwaighte JB, Raymond GM, Dash RK, Beard DA, and Nolan M. The pathway for oxygen: A modeling essay on the delivery of oxygen from air to mitochondrion. Proceedings of the 2014 International Society of Oxygen Transport to Tissue (ISOTT); Adv Exp Med Biol 876: 103-110, 2016.
59. Bazil JN, Pannala VR, Dash RK, and Beard DA. Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH:ubiquinone oxidoreductase. Free Radic Biol Med 77: 121-129, 2014.
60. Pannala VR and Dash RK. Mechanistic characterization of the thioredoxin system in the re-moval of hydrogen peroxide. Free Radic Biol Med 78:42-55, 2015.
61. Tewari SG, Zhou Y, Otto BJ, Dash RK, Kwok WM, and Beard DA. Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics. Front Physiol 5:513, 2015.
62. Salehpour F, Ghanian Z, Yang C, Kurth T, Dash RK, Cowley AW Jr, and Ranji M. Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: Optical fluorescence 3D cryoimaging. Am J Physiol Renal Physiol, 309(4): 377-382, 2015 Aug. doi: 10.1152/ajprenal.00098.2015. Epub 2015 Jun.
63. Pannala VR, Beard DA, and Dash RK. Letter to the Editor – Mitochondrial cytochrome c oxidase: Mechanism of action and role in regulating oxidative phosphorylation. J Appl Physiol, 2015 Jul 15; doi: 10.1152/japplphysiol.00290.2015.
64. Blomeyer CA#, Bazil JN#, Stowe DF, Dash RK, and Camara AKS. Mg2+ differentially regulates two modes of mitochondrial Ca2+ uptake in isolated cardiac mitochondria: Implications for mitochondria Ca2+ sequestration. J Gen Physiol, 2015 (Submitted).[# Equal contributions]
65. Dash RK#, Korman B, and Bassingthwaighte JB#. Simple accurate mathematical models of blood HbO2 and HbCO2 dissociation curves at varied physiological conditions – Evaluation and comparison with other mathematical models. Eur J Appl Physiol 116(1): 97-113, 2016 Jan. doi:10.1007/s00421-015-3228-3. Epub 2015 Aug.
66. Ranji M#, Salehpour F, Motlagh MM, Sepehr R, Heisner JS, Dash RK, and Camara AKS#. Optical cryo-imaging reveals a heterogeneous distribution of mitochondrial redox state in the ex vivo guinea pig heart and its alteration during ischemia and reperfusion. IEEE J Trans Eng Health Med 4: 1800210, 2016 Jun. doi: 10.1109/JTEHM.2016.2570219. [# Equal Contributions for Senior Authorship]
67. Pannala VR, Camara AKS, and Dash RK. Modeling the detailed kinetics of mitochondriall cytochrome c oxidase: Catalytic mechanism and nitric acid oxide inhibition. J Appl Physiol 121: 1196-1207, 2016 Now. dio: 10.1152/japplphysiol.00524.2016. Epub 2016 Sep.
68. Korman B, Dash RK, and Peyton PJ. Can mathematical modeling explain the measured magnitude of the second gas effect? Anesthesiology 128(6): 1075-1083, 2018 Jun. Epub 2018 Feb. doi: 10.1097/ALN.0000000000002131.
69. Zhang X, Dash RK#, Jacobs ER, Camara AKS, Clough AV, and Audi SH#. Integrated computational model of the bioenergetics of isolated lung mitochondria. PLoS One 13(6): e0197921, 2018 Jun. [# Equal Contribution for Senior Authorship].
70. Audi SH, Friedly N, Dash RK, Beyer AM, Clough AV, and Jacobs ER. Detection of hydrogen peroxide production in the isolated rat lung using amplex red. Free Radic Res 52(9): 1052-1062, 2018 Sep.
71. Korman B, Dash RK, and Peyton PJ. The effect of net gas volume changes on alveolar gas and arterial blood in the presence of ventilation-perfusion mismatch. J Appl Physiol 126: 558-568, 2019.
72. Nasci VL, Chuppa S, Griswold L, Goodreau K, Dash RK, and Kriegel AJ. miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells. Am J Physiol Heart Circ Physiol 316(3): H710-H721, 2019 Mar.
73. Haumann J, Camara AKS, Gadicherla AK, Navarro CD, Boelens AS, Blomeyer CA, Dash RK, Boswell MR, Kwok WM, and Stowe DF. Slow Ca2+ efflux by Ca2+/H+ exchange in cardiac mitochondria is modulated by Ca2+ reuptake via MCU, extra-matrix pH, and proton pumping by F0F1-ATPase. Front Physiol 9:1914, 2019 Feb 4.
74. Tomar N, Sadri S, Cowley AW Jr, Yang C, Qureshi N, Pannala VR Audi SH, and Dash RK. A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production. Free Rad Biol Med 134: 581-597, 2019 Apr.
75. Zhang X, Dash RK#, Clough AV, Xie D, Jacobs ER, and Audi SH#. Integrated computational model of lung tissue bioenergetics. Front Physiol 10:191, 2019 Mar 8. [Equal Contributions for Senior Authorship].
76. Haspula D, Vallejos A, Moore T, Tomar N, Dash RK, and Hoffmann BR. Influence of a hyperglycemic microenvironment on a diabetic versus healthy rat vascular endothelium reveals distinguishable mechanistic and phenotypic responses. Front Physiol 10:558, 2019 May 10.
77. Xie D, Audi SH, and Dash RK. A size modified Poisson-Boltzmann ion channel model in a solvent of multiple ionic species: Application to VDAC. J Comp Chem 41(3): 218-230, 2020 Jan 30.
78. Audi SH, Cammarata A, Dash RK, Clough AV, and Jacobs ER. Quantification of mitochondrial membrane potential in the isolated rat lung using rhodamine 6G. J Appl Physiol 128(4):892-906. 2020 Apr 1.
79. Korman B, Dash RK, and Peyton PJ. Elucidating the roles of solubility and ventilation-perfusion mismatch in the second gas effects using a two-step model of gas exchange. J Appl Physiol 128(6): 1587-1593, 2020 June 1.
80. Terhune SS#,$; Jung Y$; Cataldo K; and Dash RK#. Network mechanisms and dysfunction within an integrated computational model of the progression through mitosis in the human cell cycle. PLoS Comp Biol 16(4): e1007733, 2020 Apr 6. [# Equal Contribution for Senior Authorship; $ Equal Contribution for First Authorship].
81. Sadri S, Tomar N, Yang C, Audi SH, Cowley AW Jr, and Dash RK. Mechanistic computational modeling of the kinetics and regulation of NADPH oxidase 2 assembly and activation facilitating superoxide production. Free Rad Res 54(10): 695-721, 2020 Oct.
82. Jung Y $, Kraikivski P $#, Shafiekhani S, Terhune SS, and Dash RK #. Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: Computational modeling and analysis. NPJ Systems Biology, 2021 (under review; revised manuscript submitted in July 2021). [# Equal Contributions for Senior Authorship; $ Equal Contribution for First Authorship]
83. Tomar N $, Zhang X $, Kandel SM $, Sadri S, Chun Y, Zheleznova N, Liang M, Audi SH, Cowley AW Jr #, and Dash RK #. Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla. Biochimica Biophysica Acta Bioenergetics, 2021. [Under revision; original manuscript submitted in May 2021] [# Equal Contributions for Senior Authorship; $ Equal Contributions for First Authorship]
84. Zhang X $, Kandel SM $, Tomar N $, Yang Chun, Zheleznova N, Liang M, Audi SH, Cowley AW Jr #, and Dash RK #. Calcium regulation of mitochondrial respiration and ATP synthesis is biphasic, substrate dependent, and tissue specific. Function, 2021. [Under review; original manuscript submitted in June 2021][# Equal Contributions for Senior Authorship; $ Equal Contributions for First Authorship].
85. Zhang X, Tomar N, Audi SH, Liang M, Cowley AW Jr #, and Dash RK #. Integrated computational modeling of mitochondrial bioenergetics of kidney cortex and outer medulla. Function, 2021. [Under preparation; manuscript to be submitted in September 2021][# Equal Contributions for Senior Authorship].
86. Monti CE, Womack J, Audi SH, Hong SK, Yang Y, Kim J, and Dash RK. Physiologically-based pharmaco-kinetic (PBPK) modeling of blood clearance of liver fluorescent markers for the assessment of the degree of hepatic ischemia-reperfusion injury. IEEE Engineering in Medicine and Biology Society Conference Proceedings, Sydney, Australia, July 24-28, 2023. arXiv:2302.05511.
 
Books, Chapters, and Reviews
1. Dash RK. Theoretical Studies of Cardiovascular Flows in Small and Large Blood Vessels. PhD Thesis, Indian Institute of Technology, New Delhi, India, 1998. [Book]
2. Beard DA, Wu F, Cabrera ME, and Dash RK. Modeling of Cellular Metabolism and Micro-circulatory Transport. Microcirculation 15(8): 777-793, 2008. [Review Article]
3. Bassingthwaighte JB, Beard DA, Carlson BE, Dash RK, and Vinnakota K. Modeling to link regional myocardial work, metabolism and blood flows. Ann Biomed Eng 40(11): 2379-2398, 2012. [Review Article]
4. Pradhan RK and Dash RK. Numerical Methods and Simulations of Partial Differential Equations. In Dubitzky W, Wolkenhauer O, Cho KH, and Yokota H (Eds.), Encyclopedia of Systems Biology, 1641-1645, Springer Verlag, New York, 2013. [Book Chapter]
5. Pradhan RK, Vinnakota KC, Beard DA, and Dash RK. Carrier-Mediated Transport through Biomembranes. In Kuznetsov A and Becker S (Eds.), Transport in Biological Media (Chapter 5), Elsevier, 2013. [Book Chapter]
6. Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ, and Camara AKS. Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Special topic “Mitochondria: Hubs of cellular signaling, energetics, and redox balance”, Front Physiol 5:341, 2014. [REVIEW ARTICLE]
7. Kandel SM, Dashika SK, Dash RK, and Beard DA. Control of cardiac mitochondrial fuel selection by calcium. bioRxiv preprint, Oct 2017.
8. Sadri S, Audi SH, Zhang X, Tomar N, Cowley AW Jr, and Dash RK. Mechanistic computational modeling of enzymatic redox reactions: Application to NOX2-mediated ROS production on cell membrane. In Kuznetsov AV and Becker SM (Eds.), Modeling Mass Transport Processes in Biological Media (Ch. 19), XXX-YYY, Elsevier (Academic Press), 2021. [Book Chapter]
9. Sadri S, Audi SH, Zhang X, Tomar N, Cowley AW Jr, and Dash RK. Chemical thermodynamic principles and computational modeling of NOX2-mediated ROS production on cell membrane. In Kuznetsov AV and Becker SM (Eds.), Modeling Mass Transport Processes in Biological Media, Ch. 18, pp. 537-579, Elsevier (Academic Press), 2022. [BOOK CHAPTER]
 
Editorials, Letters To Editor, Other
1. Cowley AW Jr and Dash RK. Computational/experimental interrogation of the failing heart - A perspective on "Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts." Function 1(2): zqaa022, 2020 Oct 9.
 
Abstracts
1. Dash RK and Daripa P. A new class of models and their study for bi-directional propagation of capillary-gravity water waves. 36th Annual Meeting of the Society of Engineering Science, University of Texas, Austin, Oct 25-27, 1999.
2. Dash RK and Daripa P. New class of model equations for two-way propagation of capillary-gravity water waves. 52nd Annual Meeting of the American Physical Society, Division of Fluid Dynamics, New Orleans, Nov 21-23, 1999. [APS Suppl 44(8): p.57A]
3. Daripa P and Dash RK. On a class of Boussinesq equations for shallow water waves. International Conference on Computational Science and its Applications; Workshop on Wave Phenomena in Physics and Engineering: New Models, Algorithms, and Application, Montreal, Canada, May 18-21, 2003.
4. Dash RK and Bassingthwaighte JB. New model equations for oxyhemoglobin and carbamino hemoglobin dissociation curves. Biophysical Society Meeting, San Antonio, Mar 1-5, 2003. [Biophys J 84(2): p.460A]
5. Dash RK and Bassingthwaighte JB. A computational model for oxygen and carbon dioxide transport and exchange in the microcirculation. Experimental Biology Meeting, San Diego, Apr 11-14, 2003. [FASEB J 17(4), p.465A]
6. Dash RK and Bassingthwaighte JB. An integrative model of O2, CO2, HCO3- and H+ transport and exchange in heart. Biomedical Engineering Society Meeting, Nashville, Oct 1-4, 2003. [Abstract # 6.P4.61]
7. Dash RK, Bell BM, Kushmerick MJ, and Vicini P. Estimation of muscle oxygen uptake during muscle contraction and recovery using deconvolution. Biomedical Engineering Society Meeting, Nashville, Oct 1-4, 2003. [Abstract # 6.6.3]
8. Li Y, Dash RK, Cabrera ME, and Saidel GM. Computational studies of cellular metabolism in skeletal muscle: lumped vs. distributed models. Biomedical Engineering Society Meeting, Philadelphia, Oct 13-16, 2004. [Abstract # 54]
9. Calvetti D, Dash RK, Somersalo E, and Cabrera ME. A novel dynamic regularized deconvolution algorithm that accurately reconstructs input functions. Biomedical Engineering Society Meeting, Baltimore, Sept 29 - Oct 1, 2005. [Abstract # 472]
10. Dash RK, Somersalo E, Cabrera ME, and Calvetti D. A novel hybrid deconvolution algorithm that efficiently estimates intracellular VO2 kinetics. Biomedical Engineering Society Meeting, Baltimore, Sept 29 - Oct 1, 2005. [Abstract # 1154.P5.120]
11. Lai N, Dash RK, Saidel GM, and Cabrera ME. Model of O2 transport and metabolism in working skeletal muscle predicts in-vivo experimental data. Biomedical Engineering Society Meeting, Baltimore, Sept 29 - Oct 1, 2005. [Abstract # 1168.P5.134]
12. Li Y, Dash RK, Saidel GM, and Cabrera ME. Parameter sensitivity analysis for a large-scale model of cellular metabolism in skeletal muscle. Biomedical Engineering Society Annual Meeting, Baltimore, Sept 29 - Oct 1, 2005. [Abstract # 1170.P5.136]
13. Cabrera ME, Valentine RW, and Dash RK. Multi-scale model of whole body to predict integrated metabolic response to space travel. 56th International Astronautical Congress, Fukuoka, Japan, Oct 17-21, 2005.
14. Dash RK, Li Y, Saidel GM, and Cabrera ME. In-silico studies of cellular metabolic dynamics in skeletal muscle. 2nd Annual Meeting of the National Centers for Systems Biology: Predictive Models of Complex Systems, Friday Harbor, June 3-7, 2006.
15. Dash RK, Li Y, Saidel GM, and Cabrera ME. Skeletal muscle metabolic dynamics during reduced blood flow. 34th Annual Conference of the International Society on Oxygen Transport to Tissue (ISOTT-2006), Louisville, Aug 12-17, 2006.
16. Bassingthwaighte JB, Neal ML, Dash RK, Carlson BE, and Anderson JC. The role of hemoglobin in respiratory gas exchanges. 34th Annual Conference of the International Society on Oxygen Transport to Tissue (ISOTT-2006), Louisville, Aug 12-17, 2006.
17. Lai N, Dash RK, Saidel GM, and Cabrera ME. Oxygen delivery and utilization as limiting factors during exercise: in vivo vs. in silico studies. Biomedical Engineering Society Meeting, Chicago, Oct 12-15, 2006. [Abstract # 479]
18. Li Y, Dash RK, Kim J, Valentine RW, Saidel GM, and Cabrera ME. Regulation of skeletal muscle energy metabolism: activation mechanism with exercise. Biomedical Engineering Society Meeting, Chicago, Oct 12-15, 2006. [Abstract # 729]
19. Cabrera ME, Lai N, Dash RK, and Saidel GM. Linking internal to external respiration during exercise. Biomedical Engineering Society Meeting, Chicago, Oct 12-15, 2006. [Abstract # 1385]
20. Aldakkak M, Camara AKS, Beard DA, Dash RK, Huang M, and Stowe DF. NS1619 increases potassium influx in the isolated intact mitochondria in a dose dependent manner. Biophysical Society Meeting, Baltimore, Mar 3-7, 2007. [Biophys J, p.95A]
21. Aldakkak M, Stowe DF, Rhodes S, Beard DA, Dash RK, Huang M, and Camara AKS. Hypothermia enhances complex II substrate dependent generation of reactive oxygen species from mitochondrial complex III. Experimental Biology Meeting, Washington DC, Apr 28 – May 2, 2007. [FASEB J 21(6), p.820A; Abstract # 732.28]
22. Dash RK, Aldakkak M, Rhodes S, Camara AKS, Stowe DF, and Beard DA. Modeling the roles of Ca2+ uniporter, Na+/Ca2+ exchanger and Na+/H+ exchanger in regulating Ca2+, Na+ and pH flux in cardiac mitochondria using in-vitro spectrofluorometry. Experimental Biology Meeting, Washington DC, Apr 28 – May 2, 2007. [FASEB J 21(6), p.1352A; Abstract # 946.3]
23. Xie D, Dash RK, Wu F, and Beard DA. Parallel computational algorithm for 1D model of blood-tissue transport and metabolism. 7th International Conference on Computational and Mathematical Methods in Science and Engineering, Chicago, June 20-23, 2007.
24. Qi F, Wu F, Dash RK, and Beard DA. The adenine nucleotide translocase operates near optimal efficiency at physiological biochemical states. Biomedical Engineering Society Meeting, Los Angles, Sep 28 - Oct 2, 2007. [Abstract # 233.P1.153]
25. Qi F, Dash RK, and Beard DA. A Thermodynamically balanced kinetic model of the mitochondrial calcium uniporter. Biomedical Engineering Society Meeting, Los Angles, Sep 28 - Oct 2, 2007. [Abstract # 448.P2.8]
26. Rhodes S, Sharma S, Aldakkak M, Camara AKS, Dash RK, Beard DA, and Stowe DF. Regulation of Ca2+ flux in isolated cardiac mitochondria: novel spectrofluorometric measurements. Biomedical Engineering Society Meeting, Los Angles, Sep 28 - Oct 2, 2007. [Abstract # 454.P2.14]
27. Dash RK, Rhodes S, Sharma S, Aldakkak M, Camara AKS, Stowe DF, and Beard DA. Integrated role of mitochondrial cation transport system in the regulation of mitochondrial Ca2+. Biomedical Engineering Society Meeting, Los Angles, Sep 28 - Oct 2, 2007. [Abstract # 723.P3.4]
28. Xie D, Dash RK, Wu F, and Beard DA. Parallel numerical solution for 1D model of blood-tissue transport and metabolism. Biomedical Engineering Society Meeting, Los Angles, Sep 28 - Oct 2, 2007. [Abstract # 1612.P6.3]
29. Haumann J, Herrera M, Vega JL, Aldakkak M, Camara AKS, Bienengraeber M, Dash RK, Stowe DF. Isoflurane enhances buffer Ca2+-induced mitochondrial Ca2+ flux: Role of mitochondrial Ca2+ uniporter. Biophysical Society Meeting, Long Beach, Feb 2-6, 2008.
30. Dash RK, Stowe DF, Camara AKS, Aldakkak M, Rhodes SS, Beard DA. Computational modeling of mitochondrial Ca2+ flux via the Ca2+ uniporter: Modulation by isoflurane. Biophysical Society Meeting, Long Beach, Feb 2-6, 2008.
31. Haumann J, Patel R, Aldakkak M, Rhodes SS, Vinnakota KC, Dash RK, Camara AKS, Beard DA, and Stowe DF. ADP and CCCP–induced increases in mitochondrial free Ca2+: greater contribution of matrix Ca2+ buffering by ATP/ADP. Experimental Biology Meeting, San Diego, Apr 5-9, 2008. [FASEB J 22; Abstract # 756.6; Poster # F97]
32. Dash RK, Haumann J, Patel R, Aldakkak M, Rhodes SS, Camara AKS, Stowe DF, Vinnakota KC, and Beard DA. Regulation of mitochondrial free Ca2+ by metabolite and pH-dependent Ca2+ buffering in the matrix: Analysis by a computational model of mitochondrial Ca2+ handling. Experimental Biology Meeting, San Diego, Apr 5-9, 2008. [FASEB J 22; Abstract # 756.7; Poster # F98]
33. Li Y, Dash RK, Saha AK, Kim J, Saidel GM, and Cabrera ME. Intracellular mechanisms of regulation of muscle metabolism during exercise. Mini Symposia for 2008 MSM Consortium Meeting at the SIAM Conference on the Life Sciences, Montreal, Quebec, Canada, August 4-7, 2008.
34. Beard DA, Dash RK, Qi F, Vinnakota KC, and Wu F. Merging cellular biochemical models using physiochemically rigorous rules. Mini Symposia for 2008 MSM Consortium Meeting at the SIAM Conference on the Life Sciences, Montreal, Quebec, Canada, August 4-7, 2008.
35. Dash RK, Thompson MD, Vinnakota KC, Haumann J, Aldakkak M, Camara AKS, Stowe DF, and Beard DA. Modeling regulation of mitochondrial free Ca2+ by ATP/ADP-dependent Ca2+ buffering. Biophysical Society Meeting, Boston, Feb 28 – Mar 4, 2009. [Biophys J 96(3), p.8a; Abstract # 41-Plat]
36. Aldakkak M, Camara AKS, Haumann J, Dash RK, and Stowe DF. Substrate dependent mito-chondrial pH changes during oxidative phosphorylation. Biophysical Society Meeting, Boston, Feb 28 – Mar 4, 2009. [Biophys J 96(3), p.240a; Abstract # 1233-Pos]
37. Haumann J, Hartman C, Dash RK, Aldakkak M, Camara AKS, and Stowe DF. Characterizing the calcium uniporter: Effect of partial depolarization on calcium flux. Biophysical Society Meeting, Boston, Feb 28 – Mar 4, 2009. [Biophys J 96(3), p.244a; Abstract # 1250-Pos].
38. Haumann J, Stowe DF, Dash RK, Aldakkak M, Patel R, Vernon MR, Beard DA, and Camara AKS. ADP/ATP antiport and ADP phosphorylation increase mitochondrial free Ca2+. Biophysical Society Meeting, Boston, Feb 28 – Mar 4, 2009. [Biophys J 96(3), p244a; Abstract # 1251-Pos]
39. Haumann J, Hartman C, Aldakkak M, Dash RK, Camara AKS, and Stowe DF. Uncoupler induced graded mitochondrial depolarization and attenuated matrix calcium uptakes are enhanced by complex V inhibition indicative of blocked ATP synthesis. Experimental Biology Meeting, New Orleans, Apr 18-22, 2009.
40. Dash RK, Thompson MD, Vinnakota KC, Haumann J, Aldakkak M, Camara AKS, Stowe DF, and Beard DA. Modeling regulation of mitochondrial free Ca2+ by metabolite-dependent Ca2+ buffering. Experimental Biology Meeting, New Orleans, Apr 18-22, 2009.
41. Pradhan RK, Beard DA, and Dash RK. A thermodynamically-balanced kinetic model of mitochondrial Na+-Ca2+ antiporter. Experimental Biology Meeting, New Orleans, Apr 18-22, 2009.
42. Boelens AD, Dash RK, Haumann J, Camara AKS, Aldakkak M, Gadicherla AK, and Stowe DF. Buffer magnesium limits mitochondrial calcium uptake but not matrix calcium buffering in response to ADP. Biophysical Society Meeting, San Francisco, Feb 20-24, 2010. [Biophys J 98(3), p.736a; Abstract # 3827-Pos]
43. Aldakkak M, Stowe DF, Boelens AD, Haumann J, Dash RK, and Camara AKS. Ca2+ enhances ROS generation from inhibited complex I but not from inhibited complex II with NADH-linked substrate. Biophysical Society Meeting, San Francisco, Feb 20-24, 2010. [Biophys J 98(3), p.736a; Abstract # 3829-Pos]
44. Aldakkak M, Camara AKS, Heisner JS, Gadicherla AK, Boelens AD, Yang M, Dash RK, and Stowe DF. Ranolazine delays Ca2+-induced mitochondrial permeability transition pore opening and membrane potential depolarization in guinea pig heart mitochondria. Experimental Biology Meeting, Anaheim, Apr 24-28, 2010. [FASEB J 24; Abstract # 601.9; Poster # D154]
45. Dash RK, Pradhan RK, Agarwal B, Boelens AD, Haumann J, Camara AKS, Stowe DF, and Beard DA. Modeling regulation of mitochondrial free Ca2+ by extra-mitochondrial Mg2+ during ADP phosphorylation. Experimental Biology Meeting, Anaheim, Apr 24-28, 2010. [FASEB J 24; Abstract # 1048.4; Poster # A190]
46. Agarwal B, Boelens AD, Camara AKS, Stowe DF, Bosnjak ZJ, Beard DA, and Dash RK. Isoflurane enhances mitochondrial free Ca2+ in response to Ca2+ but not ADP: Possible role of isoflurane activating mitochondrial Ca2+ uniporter. Experimental Biology Meeting, Anaheim, Apr 24-28, 2010. [FASEB J 24; Abstract # 1048.6; Poster # A193]
47. Boelens AD, Stowe DF, Aldakkak M, Gadicherla AK, Dash RK, Haumann J, and Camara AKS. Reduced mitochondrial volume contributes but cannot fully explain the increase in matrix free Ca2+ after addition of ADP. Experimental Biology Meeting, Anaheim, Apr 24-28, 2010. [FASEB J 24; Abstract # 1048.9; Poster # A195]
48. Pradhan RK, Qi F, Beard DA, and Dash RK. Mathematical characterization of the inhibitory effect of Mg2+ on the kinetics of mitochondrial Ca2+ uniporter. Experimental Biology Meeting, Anaheim, Apr 24-28, 2010. [FASEB J 24; Abstract # 1065.6; Poster # A376]
49. Coskun S, Cheng E, Qi X, Jadeja R, Cicek E, Syed S, Bai Z, Lai N, Dash RK, Ozsoyoglu G, and Ozsoyoglu ZM. PathCaseSysBio: database-enabled tools for regulatory metabolic networks. Ohio Collaborative Conference on Bioinformatics, Columbus, June 15-17, 2010.
50. Agarwal B, Camara AKS, Stowe DF, Bosnjak ZJ, Beard DA, and Dash RK. Isoflurane increases mitochondrial free Ca2+ by enhancing transport via the Ca2+ uniporter independent of dPsim. Biophysical Society Meeting, Baltimore, Mar 5-9, 2011. [Biophys J 100(3), p.81a; Abstract # 436-Pos B236]
51. Boelens AD, Camara AKS, Dash RK, Pradhan RK, Thompson O, and Stowe DF. Increases in extra-matrix Mg2+ inhibit Ca2+ uptake via the Ca2+ uniporter but do not acutely alter state 3 respiration. Biophysical Society Meeting, Baltimore, Mar 5-9, 2011. [Biophys J 100(3), p.461a; Abstract # 2499-Pos B485]
52. Aldakkak M, Stowe DF, Dash RK, Riess ML, and Camara AKS. Excess Ca2+ enhances ROS generation from inhibited complex III with FADH2-linked substrate but not NADH-linked substrate. Experimental Biology Meeting, Washington DC, Apr 9-13, 2011. [FASEB J 25; Abstract # 639.6; Poster # D89]
53. Bazil JN, Boelens AD, Pradhan RK, Camara AKS, Stowe DF, Beard DA, and Dash RK. An integrated model that accurately characterizes Ca2+ uptake, efflux, and storage mechanisms in isolated mitochondria. Experimental Biology Meeting, Washington DC, Apr 9-13, 2011. [FASEB J 25; Abstract # 732.1; Poster # B224]
54. Pradhan RK, Boelens AD, Bazil JN, Camara AKS, Stowe DF, Beard DA, and Dash RK. Effect of extra-matrix Mg2+ on matrix free Ca2+: analysis by an integrated model of mitochondrial Ca2+ handling. Experimental Biology Meeting, Washington DC, Apr 9-13, 2011. [FASEB J 25; Abstract # 732.8; Poster # B231]
55. Qi F, Pradhan RK, Dash RK, and Beard DA. Modeling the kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase. Experimental Biology Meeting, Washington DC, Apr 9-13, 2011. [FASEB J 25; Abstract # 732.9; Poster # B232]
56. Boelens AD, Agarwal B, Stowe DF, Dash RK, and Camara AKS. Isoflurane and Mg2+ as regulators of Ca2+ uptake in cardiac mitochondria. European Society of Anesthesiology Meeting, Amsterdam, June 2011. [Eur J Anesthesiology 28, p.46; Abs# 4AP2-5]
57. Bazil JN, Pradhan RK, Blomeyer CA, Camara AKS, Stowe DF, and Dash RK. Modeling the paradoxical increase in mitochondrial calcium buffering power as matrix calcium increases. Biophysical Society Meeting, San Diego, Feb 25-29, 2012. [Biophys J 102(3), p.164a]
58. Blomeyer CA, Stowe DF, Pradhan RK, Bazil JN, Dash RK, Camara AKS. Sodium-induced calcium effluxes via mitochondrial NCE are dissimilar when derived from matrix and extra-matrix calcium concentrations. Biophysical Society Meeting, San Diego, Feb 25-29, 2012. [Biophys J 102(3), p.164a]
59. Pradhan RK, Blomeyer CA, Bazil JN, Camara AKS, Stowe DF, and Dash RK. Modeling dynamic regulation of mitochondrial free Ca2+: Effects of Ca2+ sequestration and precipitation. Experimental Biology Meeting, San Diego, Apr 21-25, 2012. [FASEB J 26; Abs#585.4]
60. Aldakkak M, Stowe DF, Dash RK, and Camara AKS. Mitochondrial handling of excess Ca2+ is substrate-dependent with implications on ROS generation. Experimental Biology Meeting, San Diego, Apr 21-25, 2012. [FASEB J 26; Abs#678.17]
61. Agarwal B, Camara AKS, Stowe DF, Bosnjak ZJ, Beard DA, and Dash RK. Isoflurane increases mitochondrial free Ca2+ by attenuating Na+/Ca2+ exchanger activity. Experimental Biology Meeting, San Diego, Apr 21-25, 2012. [FASEB J 26; Abs#888.4]
62. Jeneson JAL, Dash RK, Vinnakota KC, Wu F, Beard DA, and Wiseman RW. Mitochondrial sensitivity to regulatory signals in muscle energy balance: Is it constant during exercise? Experimental Biology Meeting, San Diego, Apr 21-25, 2012. [FASEB J 26; Abs#887.13]
63. Bazil JN, Blomeyer CA, Camara AKS, and Dash RK. Modeling the mitochondrial calcium sequestration system. 2012 ASBMB Special Symposia Series, Mitochondria: Energy, Signals, and Homeostasis, MSU East Lansing, June 28-29, 2012.
64. Dash RK, Wiseman RW, Jeneson JAL, Vinnakota KC, Wu F, and Beard DA. Regulation of pyruvate dehydrogenase in skeletal muscle during altered energy demand: Inference from computational analysis of phosphoenergetics data from 31P-NMRS. National Centers of Systems Biology Meeting, Chicago, July 17-18, 2012.
65. Bazil JN, Blomeyer CA, Camara AKS, and Dash RK. Elucidating the mechanism of mitochondrial calcium sequestration. Special Workshop on Model-based Analysis and Control of Cellular Processes, Purdue University, Oct 08-09, 2012.
66. Tewari SG, Bazil JN, Beard DA, and Dash RK. A biophysical model of the carboxyatractyloside-insensitive ATPMg/Pi carrier. Biomedical Engineering Society Meeting, Atlanta, Oct 24-27, 2012.
67. Agarwal B, Dash RK, Bosnjak ZJ, Stowe DF, and Camara AKS. Substrate-dependent action of isoflurane on electron transport chain complexes. Experimental Biology Meeting, Boston, Apr 20-24, 2013. [FASEB J 27, Abs#1209.9]
68. Tewari SG, Zhoub Y, Camara AKS, Dash RK, and Kwok WM. Post-translationally modified cardiac mitochondrial VDAC1 gating kinetics analyzed using continuous-time MCMC model. Experimental Biology Meeting, Boston, Apr 20-24, 2013. [FASEB J 27; Abs#1209.15]
69. Tewari SG, Pradhan RK, Bazil JN, Stowe DF, Camara AKS, and Dash RK. Characterization of different modes of Ca2+ uptake under physiological conditions in cardiac mitochondria. Experimental Biology Meeting, Boston, Apr 20-24, 2013. [FASEB J 27; Abs#1209.20]
70. Jeneson JAL, Dash RK, Beard DA, and Wiseman RW. Kinetic model-based analysis of dynamic 31P-NMRS data on ATP metabolism in rat hindlimb muscle. ISMRM Annual Meeting, Salt Lake City, Apr 20-26, 2013 [MRS & Metabolism; Abstract # 1965].
71. Stowe DF, Agarwal B, Dash RK, and Camara AKS. Effects of isoflurane on mitochondrial electron transport chain complexes I and III are substrate dependent. International Anesthesia Research Society Meeting, San Diego, May 4-7, 2013. [Anesthesia Analgesia 116, p.35]
72. Aldakkak M, Stowe DF, Dash RK, Benjamin IJ, and Camara AKS. Excess Ca2+ and succinate induce mitochondrial permeability transition through complex I and ROS generation from inhibited complex III. Annual Meeting of the Foundation Leduc Transatlantic Network of Excellence on Redox and Nitrosative Regulation of Cardiac Remodeling: Novel Therapeutic Approaches for Heart Failure, Turin, Italy, Sept 9-12, 2013.
73. Tewari SG, Otto BJ, Cheng Q, Zhou YF, Dash RK, and Kwok WM. Markov chain Monte Carlo model analysis of cardiac mitochondrial VDAC1 kinetics. Biophysical Society Meeting, San Francisco, Feb 15-19, 2014. [Biophys J 106(2), p.761a]
74. Blomeyer CA, Bazil JN, Stowe DF, Dash RK, and Camara AKS. The potential for another calcium uptake mode in cardiac mitochondria. Biophysical Society Meeting, San Francisco, Feb 15-19, 2014. [Biophys J 106(2), p.242a]
75. Agarwal B, Dash RK, Bosnjak ZJ, Stowe DF, and Camara AKS. Isoflurane induces substrate-dependent early mitochondrial PTP opening. Experimental Biology Meeting, San Diego, Apr 26-30, 2014. [FASEB J 28; Abs#648.13]
76. Bassingthwaighte JB, Raymond GM, Dash RK, Beard DA, and Nolan M. The pathway for oxygen: A modeling essay on the delivery of oxygen from air to mitochondrion. 42nd Meeting of the International Society on Oxygen Transport to Tissue (ISOTT-2014), University College of London, UK, June 28 – July 3, 2014.
77. Zhang X, Dash RK, Clough AV, Jacobs ER, and Audi SH. Mechanistic computational model of lung tissue bioenergetics and the effect of acute lung injury. Biomedical Engineering So-ciety Meeting, San Antonio, Oct 22-25, 2014. [Abstract # P-Fri-526]
78. Pannala VR and Dash RK. Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. Biomedical Engineering Society Meeting, San Antonio, Oct 22-25, 2014. [Abstract # P-Th-292]
79. Bazil JN, Pannala VR, Dash RK, and Beard DA. Simulating free radical production from complex I. Biophysical Society Meeting, Baltimore, Feb 7-11, 2015. [Biophys J 108(2), p.311a; 1557-pos]
80. Pannala VR and Dash RK. Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. Biophysical Society Meeting, Baltimore, Feb 7-11, 2015. [Biophys J 108(2), p.610a-611a; 3080-pos].
81. Agarwal B, Dash RK, Bosnjak ZJ, Stowe DF, Kwok WM, Turner LA, and Camara AKS. Isoflurane induces substrate-dependent transient mitochondrial PTP opening. Association of University Anesthesiologists 62nd Annual Meeting, Nashville, TN, Apr 23-25, 2015.
82. Xiao Z, Dash RK, Pannala VR, Clough AV, Camara AKS, Jacobs ER, and Audi SH. Thermodynamically constrained computational model of lung mitochondrial bioenergetics. Proceedings of the Biomedical Engineering Society Annual Meeting, Tampa, Oct 7-10, 2015 (1-page, peer-reviewed extended abstract).
83. Pannala VR and Dash RK. Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. Proceedings of the Biomedical Engineering Society Annual Meeting, San Antonio, Oct 22-25, 2014. [One-Page Peer-Reviewed Extended Abstract]
84. Zhang X, Dash RK, Clough AV, Jacobs ER, and Audi SH. Mechanistic computational model of lung tissue bioenergetics and the effect of acute lung injury. Proceedings of the Biomedical Engineering Society Annual Meeting, San Antonio, Oct 22-25, 2014. [One-Page Peer-Reviewed Extended Abstract]
85. Manhas N, Garcia G, Pannala VR, Kwok WM, Camara AKS, and Dash RK. Modeling the effects of volatile anesthetics on L-type Ca2+ channels and Ca2+ induced Ca2+ release in cardiac myocytes. Proceedings of the Biomedical Engineering Society Annual Meeting, Minneapolis, Oct 5-8, 2016. [One-Page Peer-Reviewed Extended Abstract]
86. Pannala VR, Camara AKS, Audi SH, and Dash RK. Modeling the detailed kinetics and nitric oxide inhibition of mitochondrial cytochrome c oxidase. Proceedings of the Biomedical Engineering Society Annual Meeting, Minneapolis, Oct 5-8, 2016. [One-Page Peer-Reviewed Extended Abstract]
87. Zhang X, Dash RK, Pannala VR, Clough AV, Camara AKS, Jacobs ER, and Audi SH. Integrated model of lung mitochondrial TCA cycle and electron transport system. Proceedings of the Biomedical Engineering Society Annual Meeting, Minneapolis, Oct 5-8, 2016. [One-Page Peer-Reviewed Extended Abstract]
88. Jung Y, Cataldo K, Terhune SS, and Dash RK. Modeling mitotic cell cycle in human cells and its dysregulation during cellular perturbations. Proceedings of the Biomedical Engineering Society Annual Meeting, Atlanta, Oct 17-20, 2018. [One-Page Peer-Reviewed Extended Abstract]
89. Pannala VR, Camara AKS, and Dash RK. A thermodynamically constrained mechanistic mathematical model for the catalytic action of mitochondrial cytochrome c oxidase. Experimental Biology Meeting, San Diego, Apr 2-6, 2016. [Abstract # B235 942.11]
90. Bassingthwaighte JB, Jardine B, and Dash RK. A dynamical computational model of circulating blood gasses, hemoglobin binding, and pH regulation in the microcirculation. Experimental Biology Meeting, San Diego, Apr 2-6, 2016. [Abstract # B33 946.14]
91. Camara AKS, Salehpour F, Motlagh MM, Sepehr R, Heisner JS, Dash RK, and Ranji M. Optical cryo-imaging reveals a heterogeneous distribution of mitochondrial redox state in the ex vivo guinea pig heart and its alteration during ischemia and reperfusion. Experimental Biology Meeting, San Diego, Apr 2-6, 2016. [Abstract # W58 1278.7]
92. Manhas N, Garcia G, Pannala VR, Kwok WM, Camara AKS, and Dash RK. Modeling the effects of volatile anesthetics on L-type Ca2+ channels and Ca2+ induced Ca2+ release in cardiac myocytes. Biomedical Engineering Society Meeting, Minneapolis, Oct 5-8, 2016. [Abstract # PP-Th-340]
93. Zhang X, Dash RK, Pannala VR, Clough AV, Camara AKS, Jacobs ER, and Audi SH. Integrated model of lung mitochondrial TCA cycle and electron transport system. Biomedical Engineering Society Meeting, Minneapolis, Oct 5-8, 2016. [Abstract # PP-Th-546]
94. Pannala VR, Camara AKS, Audi SH, and Dash RK. Modeling the detailed kinetics and nitric oxide inhibition of mitochondrial cytochrome c oxidase. Biomedical Engineering Society Meeting, Minneapolis, Oct 5-8, 2016. [Abstract # OP-Thurs-3-13]
95. Manhas N, Garcia G, Kwok WM, Camara AKS, and Dash RK. Modeling the effects of volatile anesthetics on L-type Ca2+ channels and Ca2+ induced Ca2+ release in cardiomyocytes. Biophysical Society Meeting, New Orleans, Feb 11-15, 2017. [Abstract # 534-Pos]
96. Tomar N, Pannala VR, Yang C, Audi SH, Cowley AW Jr, and Dash RK. A thermodynamically constrained mechanistic mathematical model for the kinetics of NADPH oxidase 2 assembly, activation and ROS production. Experimental Biology Meeting, Chicago, Apr 22-26, 2017. [Abstract # F45 722.11]
97. Davani AJ, Navarro CD, Heisner JS, Pannala VR, Dash RK, Stowe DF, and Camara AKS. The mitochondrial adenine nucleotide pool contributes to the matrix Ca2+ buffering system. Experimental Biology Meeting, Chicago, Apr 22-26, 2017. [Abstract # E368 696.5]
98. Przekwas AJ, Somayaji MR, Das D, Chen ZJ, Lebeda FJ, Dash RK, and Ramasubramanian AK. Systems biology based tools for modeling platelet storage lesion for optimal blood transfusions. Military Health System Research Symposium (MHSRS), Kissimmee-FL, Aug 27-31, 2017.
99. Kandel SM, Dashika SK, Dash RK, and Beard DA. Role of calcium and ADP infusion rates in cardiac mitochondrial fuel selection. Cardiac Physiome Meeting, Toronto, Canada, Nov 6-9, 2017.
100. Manhas N, Camara AKS, and Dash RK. Modeling mechanisms of cardiac L-type Ca2+ channel regulation: Interactions of voltage, Ca2+, and isoflurane. Cardiac Physiome Meeting, Toronto, Canada, Nov 6-9, 2017.
101. Tomar N, Cowley AW Jr, Audi SH, and Dash RK. Molecular modeling of NADPH oxidase 2 assembly, activation and ROS production. Cardiac Physiome Meeting, Toronto, Canada, Nov 6-9, 2017.
102. Manhas N, Camara AKS, and Dash RK. Modeling mechanisms of cardiac L-type Ca2+ channel regulation: Interactions of voltage, Ca2+, and Isoflurane. Biophysical Society Meeting, San Fransisco, Feb 17-21, 2018. [Abstract # 1521-Pos]
103. Kandel SM, Dashika SK, Dash RK, and Beard DA. Role of calcium and ADP infusion rates in cardiac mitochondrial fuel selection. Biophysical Society Meeting, San Francisco, Feb 17-21, 2018. [Abstract # 3261-Pos]
104. Mishra J, Davani AJ, Stowe DF, Dash RK, Kwok WM, Camara AKS. Cyclosporine A: New insights into its potential role in mitochondrial Ca2+ buffering. Biophysical Society Meeting, San Francisco, Feb 17-21, 2018. [Abstract # 3269-Pos]
105. Zhang X, Dash RK, Clough AV, Camara AKS, Jacobs ER, and Audi SH. Thermodynamically constrained computational model of lung mitochondrial bioenergetics. Biophysical Society Meeting, San Francisco, Feb 17-21, 2018. [Abstract # L3859-Pos]
106. Haspula D, Vallejos A, Moore T, Tomar N, Dash RK, and Hoffman BR. Differential responses of GK and WKY rat microvascular endothelial cells to a hyperglycemic environment. Experimental Biology Meeting, San Diego, Apr 21-25, 2018. [Abstract # W52 902.6-Pos]
107. Kandel SM, Tomar N, Audi SH, Camara SH, Cowley AW Jr, and Dash RK. Calcium regulation of mitochondrial respiration is substrate dependent and tissue specific. Experimental Biology Meeting, San Diego, Apr 21-25, 2018. [Abstract # LB161-Pos]
108. Jung Y, Cataldo K, Terhune SS, and Dash RK. Modeling mitotic cell cycle in human cells and its dysregulation during cellular perturbations. Biomedical Engineering Society Meeting, Atlanta, Oct 17-20, 2018. [Abstract # P-TH-31]
109. Tomar N, Kandel SM, Zheleznova N, Audi SH, Cowley AW Jr, and Dash RK. Ca2+ dependent mitochondrial permeability transition pore opening in kidney is substrate dependent. Biophys J Suppl 116(3), 2019 Feb 15, p269a. Biophysical Society Meeting, Baltimore, Mar 2-6, 2019. [Abstract # 1326-Pos]
110. Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley AW Jr, and Dash RK. Differential regulation of substrate-dependent mitochondrial respiration in the heart and kidney. Biophys J Suppl 116(3), 2019 Feb 15, p271a. Biophysical Society Meeting, Baltimore, Mar 2-6, 2019. [Abstract # 1333-Pos]
111. Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley AW Jr, and Dash RK. Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J Suppl 116(3), 2019 Feb 15, p271a. Biophysical Society Meeting, Baltimore, Mar 2-6, 2019. [Abstract # 1334-Pos]
112. Zhang X, Dash RK, Clough AV, Xie D, Jacobs ER, and Audi SH. Integrated computational model of lung tissue bioenergetics. Biophys J Suppl 116(3), 2019 Feb 15, p560-561a. Biophysical Society Meeting, Baltimore, Mar 2-6, 2019 [Abstract # 2780-Pos]
113. Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley AW Jr, and Dash RK. The role of calcium in the regulation of mitochondrial respiration under various substrate combinations in the heart and kidney. Experimental Biology Meeting, Orlando, April 6-9, 2019. [Abstract # E609 579.2-Pos]
114. Jones E, Van den Bergh F, Kandel SM, Dashika SK, Dash RK, and Beard DA. Control of cardiac mitochondrial fuel selection by calcium. Experimental Biology Meeting, Orlando, April 6-9, 2019. [Abstract # E499LB-Pos]
115. Haspula D, Vallejos A, Moore T, Tomar N, Dash RK, and Hoffman BR. Influence of a hyperglycemic microenvironment on a healthy vs. diabetic rat vascular endothelium reveals distinct mechanistic and phenotypic responses. Experimental Biology Meeting, Orlando, April 6-9, 2019. [Abstract # C253 828.13-Pos]
116. Terhune SS, Jung Y, Cataldo K, and Dash RK. Defining virus-mediated network dysfunction using an integrated computational model of the mitotic cell cycle. 38th Annual Meeting of the American Society of Virology, University of Minnesota, July 20-24, 2019.
117. Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley AW Jr, and Dash RK. Mitochondrial dysfunction in the heart and kidney during the progression of salt-sensitive hypertension. APS/ASN Renal Conference. Charlottesville, June 23-25, 2019.
118. Zhang X, Tomar N, Kandel SM, Sadri S, Audi SH, Cowley AW Jr, and Dash RK. Characterizing substrate dependent differential regulation of mitochondrial respiration in the heart and kidney using computational modeling. Experimental Biology Meeting, San Diego, April 3-7, 2020 (cancelled due to COVID-19).
119. Tomar N, Kandel SM, Zheleznova N, Audi SH, Cowley AW Jr, and Dash RK. Progressive alterations of mitochondrial function in the kidney and heart during the development of salt-induced hypertension. Experimental Biology Meeting, San Diego, April 3-7, 2020 (cancelled due to COVID-19).
120. Sadri S, Tomar N, Audi SH, Cowley AW Jr, and Dash RK. Integrated computational modeling of the kinetics and regulation of NADPH oxidase 2 assembly, activation, electron flow, and superoxide production. Experimental Biology Meeting, San Diego, April 3-7, 202 (cancelled due to COVID-19).
121. Tomar N, Kandel SM, Zhang X, Zheleznova N, Cowley AW Jr, and Dash RK. Progressive alterations of mitochondrial bioenergetics in the kidney during the development of salt-induced hypertension. AHA Hypertension Scientific Session, Sept 10-13, 2020 (virtual meeting due to COVID-19).
122. Pant T, Narayan S, Dash RK, Kalyanaraman B, and Bosnjak ZJ. Disease modeling doxorubicin-induced cardiotoxicity using human induced pluripotent-stem-cell-derived cardiomyocytes from healthy and type 2 diabetic patients. AHA Cardio-Oncology Scientific Session, Nov 13-16, 2020 (virtual meeting due to COVID-19).
123. Sadri S, Tomar N, Audi SH, Cowley AW Jr, and Dash RK. Integration of a random-rapid-equilibrium binding model of NOX2 assembly and activation with a five-state rate-limiting model of NOX2 electron flow facilitating superoxide production. Experimental Biology Meeting, April 27-30, 2021 (virtual meeting due to COVID-19).
124. Shimada S, Dash RK, and Cowley AW Jr. High-salt diet increases renal oxygen consumption in Sprague-Dawley rats. Experimental Biology Meeting, APril 27-30, 2021 (virtual meeting due to COVID-19).
125. Shimada S, Dash RK, and Cowley AW Jr. Changes in renal oxygen consumption with high-salt diet differ between Sprague-Dawley and Dahl salt-sensitive rats. AHA Hypertension Scientific Session, Sept 10-13, 2021 (virtual meeting due to COVID-19).
126. Tomar N, Cowley AW Jr, Audi SH, and Dash RK. A thermodynamically constrained mechanistic mathematical model for the kinetics of NADPH oxidase 2 assembly, activation and ROS production. Research Day Poster, Medical College of Wisconsin - Milwaukee, WI, Sep 12, 2017.
127. Pannala VR and Dash RK. Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. Proceedings of the First Redox Biology Program Meeting, Medical College of Wisconsin, Milwaukee, WI, Nov 14, 2014.
128. Camara AKS, Dash RK, Agarwal B, Kwok WM, and Bosnjak ZJ. The pleiotropic actions of isoflurane on mitochondria: Implications for cardioprotection. The 9th International Conference on Mechanisms of Anesthesia (MAC2015), Berlin, Germany, June 17-19, 2015.
129. Shah V, Womack J, Zamora AE, Terhune SS, and Dash RK. Simulating the evolution of signaling signatures during CART cell – tumor cell interactions. IEEE Engineering in Medicine and Biology Society Conference Proceedings, Sydney, Australia, July 24-28, 2023.
130. Monti CE, Womack J, Audi SH, Hong SK, Yang Y, Kim J, and Dash RK. Physiologically-based pharmaco-kinetic (PBPK) modeling of blood clearance of liver fluorescent markers for the assessment of the degree of hepatic ischemia-reperfusion injury. IEEE Engineering in Medicine and Biology Society Conference Proceedings, Sydney, Australia, July 24-28, 2023.
131. Monti CE, Mokry RL, Schumacher ML, Rosas S, Dash RK, and Terhune SS. Replication efficiencies of HCMV-infected ARPE19 cells are dependent on source of virus production. International Herpes-virus Workshop-2023. Missoula, Montana, July 15-19, 2023.
132. Monti CE, Womack J, Audi SH, Hong SK, Yang Y, Kim J, and Dash RK. Physiologically-based pharmaco-kinetic (PBPK) modeling of sodium fluorescein (SF) blood clearance for assessing hepatic ischemia-reperfusion injury (IRI). American Physiological Society Summit, Long Beach, CA, Apr 19-23, 2023.
133. Audi SH, Taheri P, Dash RK, Hu K, Zhao M, Jacobs ER, and Clough AV. Lung uptake of 99mTc-hexa-methylpropyleneamine oxime (HMPAO) and 99mTc-duramycin (DU) in rats susceptible to hyperoxia-induced acute respiratory distress syndrome (ARDS). American Physiological Society Summit, Long Beach, CA, Apr 19-23, 2023.
134. Taheri P, Dash RK, Dave DD, Clough AV, Jacobs ER, and Audi SH. Assessment of mitochondrial function and vascular permeability in lungs of rats susceptible to hyperoxia-induced acute respiratory distress syndrome (ARDS). American Physiological Society Summit, Long Beach, CA, Apr 19-23, 2023.
135. Dash RK, Yang C, Shimada S, Zheleznova NN, and Cowley AW Jr. Alterations of mitochondrial respiratory function in isolated nephron segments of Dahl salt-sensitive rats in salt-induced hypertension. American Physiological Society Summit, Long Beach, CA, Apr 19-23, 2023.
136. Shimada S, Hoffmann BR, Yang C, Kurth T, Greene AS, Liang M, Dash RK, and Cowley AW Jr. The effects of excess salt intake on the kidney metabolism in normal Sprague Dawley rats. American Physiological Society Summit, Long Beach, CA, Apr 19-23, 2023.
137. Womack JA, Shah V, Audi SH, Terhune SS, and Dash RK. BioModME for building and simulating dynamic computational models of complex biological networks. Biomedical Engineering Society Meeting, San Antonio, TX, October 12-15, 2022.
138. Sadri S, Zhang X, Dave DD, Tomar N, Audi SH, Cowley AW Jr, and Dash RK. Characterizing substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla using a novel computational model. Biomedical Engineering Society Meeting, San Antonio, TX, October 12-15, 2022.
139. Dash RK, Tomar N, Sadri S, Yang C, Audi SH, Liang M, and Cowley AW Jr. Role of NOX-induced oxidative stress in mitochondrial bioenergetic dysfunction in the kidney cortex and outer medulla of Dahl salt-sensitive rats during the development of hypertension. American Heart Association Hypertension Council. San Diego, CA, Sept 6-10, 2022.
140. Cowley AW Jr, Yang C, Isaeva E, Shimada S, Kurth T, Stumpf M, Kriegel A, and Dash RK. Tubular sites of mTORC2 inhibition of sodium transport in Dahl SS rats. American Heart Association Hypertension Council. San Diego, CA, Sept 6-10, 2022.
141. Shimada S, Hoffmann BR, Greene A, Liang M, Dash RK, and Cowley AW Jr. Compensatory changes in the metabolomic profiles in the kidney of Sprague-Dawley rats fed a high-salt diet. American Heart Association Hypertension Council. San Diego, CA, Sept 6-10, 2022.
142. Monti CE, Mokry RL, Schumacher ML, Dash RK, and Terhune SS. Mathematical modeling of protracted HCMV replication using genome substrates and protein temporal profiles. American Society of Virology Annual Meeting, Madison, WI, July 10-12, 2022.
143. Sadri S#, Zhang X, Tomar N, Audi SH, Cowley AW Jr, and Dash RK. Computational modeling of substrate-dependent differential regulation of mitochondrial bioenergetics in kidney cortex and outer medulla. World Congress on Biomechanics, Taipei, Taiwan, July 10-14, 2022 (virtual meeting due to COVID-19).
144. Tomar N, Sadri S, Yang C, Audi SH, Liang M, Cowley AW Jr, and Dash RK. Biphasic alterations of mitochondrial bioenergetics in the kidney during the development of salt-induced hypertension: Role of NOX-induced ROS and oxidative stress. American Physiological Society Kidney Camp, Charlottesville, VA, June 25-28, 2022.
145. Yang C, Zheleznova NN, Liang M, Dash RK, and Cowley AW Jr. Assessment of mitochondrial respiratory function in isolated nephron segments of Dahl SS rats in salt-induced hypertension. American Physiological Society Kidney Camp, Charlottesville, VA, June 25-28, 2022.
146. Shimada S, Hoffmann B, Greene A, Liang M, Dash RK, and Cowley AW Jr. Compensatory changes in oxygen extraction and metabolomic profiles in the kidney of Sprague-Dawley rats fed a high-salt diet. American Physiological Society Kidney Camp, Charlottesville, VA, June 25-28, 2022.
147. Audi SH, Ganesh S, Taheri P, Zhang X, Dash RK, Clough AV, and Jacobs ER. Depolarized mitochondrial membrane potential and protection with duroquinone in isolated perfused lungs from rats exposed to hyperoxia. Experimental Biology Meeting, Philadelphia, Apr 2-5, 2022. [Abstract # 879.4]
148. Sadri S, Tomar N, Zhang X, Yang C, Audi SH, Cowley AW Jr, and Dash RK. Reverse electron transfer is a more dominant source of mitochondrial ROS production in the heart and kidney outer medulla than in the kidney cortex. Experimental Biology Meeting, Philadelphia, Apr 2-5, 2022. [Abstract # 879.5]
149. Shimada S, Hoffmann BR, Yang C, Kurth T, Greene AS, Liang M, Dash RK, and Cowley AW Jr. High salt diet shifts metabolism in the kidneys of SD rats from TCA-dependent to non-TCA-dependent. American Heart Association Hypertension Council, Boston, MA, Sept 7-11, 2023.
150. Shimada S, Dash RK, and Cowley AW Jr. Impact of NADPH oxidase 4 knockout on renal O2 consumption in Dahl salt-sensitive rats. American Heart Association Hypertension Council, Boston, MA, Sept 7-11, 2023.
151. Yang C, Dash RK, Kurth T, Shimada S, and Cowley AW Jr. High salt induced mitochondrial uncoupling and enhanced respiratory activity in isolated proximal tubules from Dahl salt-sensitive rats. American Heart Association Hypertension Council, Boston, MA, Sept 7-11, 2023.
152. Monti CE, Parab K, Womack J, Hong SK, Yang Y, Kim J, Audi SH, and Dash RK. Physiologically-based pharmacokinetic computational modeling of sodium fluorescein blood clearance for the assessment of the degree of hepatic ischemia-reperfusion injury. Biomedical Engineering Society Meeting, Seattle, Oct 14-17, 2023.
153. Monti CE, Mokry RL, Rosas-Rogers S, Schumacher ML, Terhune SS, and Dash RK. Computational modeling of replication efficiency and late protein synthesis variabilities in HCMV-infected ARPE19 cells. Biomedical Engineering Society Meeting, Seattle, Oct 14-17, 2023.
154. Taheri P, Dash RK, Dave DD, Clough AV, Jacobs ER, and Audi SH. Quantitative assessment of mitochondrial function in lungs of rats susceptible to hyperoxia-induced acute respiratory distress syndrome (ARDS). Biomedical Engineering Society Meeting, Seattle, Oct 14-17, 2023.
155. Shah V, Womack J, Zamora AE, Terhune AA, and Dash RK. Simulating signaling dynamics in chimeric antigen receptor T-cells. Biomedical Engineering Society Meeting, Seattle, Oct 14-17, 2023.
156. Womack JA, Shah V, Audi SH, Terhune SS, and Dash RK. BioModME: A web application for building and simulating dynamic computational models. Biomedical Engineering Society Meeting, Seattle, October 14-17, 2023.
157. Dash RK, Yang C, Dave DD, Kurth T, Shimada S, and Cowley AW Jr. High salt induced alterations in substrate metabolism, respiratory activity, and acidification in isolated proximal tubules from Dahl salt-sensitive rats. American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024.
158. Dave DD, Fox A, Yang C, Audi SH, Cowley AW Jr, and Dash RK. Sex-specific mitochondrial bio-energetics differences in heart and kidney cortex. American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024.
159. Taheri P, Dash RK, Dave DD, Clough AV, Jacobs ER, and Audi SH. Mitochondrial function in lungs of rats with different susceptibilities to hyperoxia-induced acute respiratory distress syndrome (ARDS). American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024.
160. Shimada S, Yang C, Dash RK, and Cowley AW Jr. Dynamic shift towards increased O₂ consumption and reduced lactate uptake during acute volume expansion in Sprague Dawley rats. American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024.
161. Dave DD, Hong SK, Audi SH, Joshi A, Kim J, and Dash RK. Altered hepatic mitochondrial bioenergetics and oxidant emission with ischemia and reperfusion. American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024. [Distinguished Abstract Award]
162. Monti C, Audi SH, Hong SK, Yang Y, Kim J, and Dash RK. Computational modeling of sodium fluo-rescein disposition in ex vivo, machine-perfused livers with ischemia-reperfusion injury. American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024.
163. Shimada S, Yang C, Dash RK, and Cowley AW Jr. NADPH oxidase 4 knockout in Dahl salt-sensitive rats impacts kidney O₂ consumption and UCP2 responses to a high salt diet. American Physiological Society Summit, Long Beach, CA, Apr 4-7, 2024.