CURRICULUM VITAE
Ravindra P. Misra PhD
Ravindra P. Misra PhD
Associate Provost, Professor
Department of Biochemistry
Department of Biochemistry
OFFICE ADDRESS: |
Hub for Collaborative Medicine |
8701 Watertown Plank Road |
Milwaukee, WI 53226 |
Fax: 414-456-6510 |
EDUCATION: |
09/1975 - 05/1979 BA - Microbiology/Religion, Rutgers College, Rutgers University, New Brunswick, NJ |
09/1982 - 06/1985 MSc - Biochemistry, New York University School of Medicine, New York, NY |
07/1985 - 02/1988 PhD - Biochemistry, New York University School of Medicine, New York, NY |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
02/1988 - 02/1991 Postdoctoral Fellow (NIH-NRSA), Department of Microbiology & Molecular Genetics, Harvard Medical School, Laboratory of Michael E. Greenberg, Ph.D., Boston, MA |
03/1991 - 10/1993 American Cancer Society Senior Postdoctoral Fellow, Department of Microbiology & Molecular Genetics, Harvard Medical School, Laboratory of Michael E. Greenberg, Ph.D., Boston, MA |
FACULTY APPOINTMENTS: |
11/1993 - 06/2000 Assistant Professor, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI |
07/2000 - 06/2006 Associate Professor, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI |
07/2006 - Present Professor, w/Tenure Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
05/2010 - Present Dean, Graduate School of Biomedical Sciences. Medical College of Wisconsin, Milwaukee, WI |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
08/2013 - Present Director, MCW Campus Shared Research Resources |
AWARDS AND HONORS: |
1982 - 1985 National Research Service Award, Predoctoral Training, National Institutes of Health |
1983 - 1984 University Fellowship, New York University Graduate School of Arts & Sciences |
1988 Postdoctoral Fellowship, American Cancer Society |
1988 - 1991 Individual National Research Service Award, National Institutes of Health, NIGMS |
1991 - 1993 Senior Postodoctoral Fellowship, American Cancer Society, Massachusetts Division |
2008 - 2009 Outstanding Medical Student Teacher Award, Medical College of Wisconsin |
2009 - 2010 Outstanding Medical Student Teacher Award, Medical College of Wisconsin |
2010 - 2011 Outstanding Medical Student Teacher Award, Medical College of Wisconsin |
2011 - 2012 Outstanding Medical Student Teacher Award, Medical College of Wisconsin |
2012 - 2013 Outstanding Medical Student Teacher Award, Medical College of Wisconsin |
2013 - 2014 Outstanding Medical Student Teacher Award, Medical College of Wisconsin |
2013 - Present Alpha Omega Alpha, Medical College of Wisconsin Chapter |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
American Association for the Advancement of Science (Member) |
Milwaukee Academy of Medicine (Member) |
American Society of Biochemistry and Molecular Biology (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
Archives of Biochemistry and Biophysics |
Stem Cell Reviews and Reports |
Atherosclerosis, Thrombosis, & Vascular Biology |
Biochemistry |
BMC Cell Biology |
BMC Developmental Biology |
Cancer Research |
Cell Science |
Circulation Research |
Current Medicinal Chemistry |
Developmental Dynamics |
EMBO Journal |
Endocrinology |
Experimental Cell Research |
Experimental Gerontology |
Genomics |
Journal of Biological Chemistry |
Journal of Pharm and Exp Therapeutics |
Journal of Cellular Physiology |
Journal of Developmental Biology |
Journal of Neurochemistry |
Journal of Neuroscience |
Molecular and Cellular Biology |
Molecular Cellular Biochemistry |
Molecular Endocrinology |
Nucleic Acids Research |
Oncogene |
PLoS One |
Proceedings National Academy Sciences, U.S.A. |
Protein Expression & Purification |
Preclinica |
Anatomical Records |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2001 Ad hoc referee, Molecular and Cell Panel, The Wellcome Trust |
2003 - 2007 Ad hoc referee, Training Fellowship Panel, The Wellcome Trust |
2003 Ad hoc referee, David Phillips Fellowship Panel, Biotechnology and Biological Sciences Research Council, UK |
2004 - 2010 Reviewer, National Scientific Advisory Council (NSAC), American Federation of Aging Research (AFAR) |
2004 Reviewer, Cardiovascular Signaling and Transcription, NIHZRG1 CVS-E 02 |
06/2005 Ad hoc reviewer, Cardiovascular Differentiation and Development Study Section, NIH |
2006 - 2010 Charter member, Cardiovascular Differentiation and Development Study Section, NIH |
2006 - 2010 Ad hoc referee, Genes & Developmental Biology (GDB) Committee, Biotechnology and Biological Sciences Research Council, UK |
07/2009 Ad hoc reviewer, Cardiac Signaling, Development and Toxicity (Teleconference), ZRG1 CVRS-K (02) S |
2009 Abstract Reviewer, Scientific Sessions, Angiogensis, American Heart Association |
2009 Ad hoc reviewer, Grand Opportunities in Characterizing Differentiated Stem Cells (ARRA), ZHL1 CSR-W NHLBI |
04/2012 Reviewer, Regenerative Cell Biology 1, American Heart Association |
04/2013 Reviewer, Regenerative Cell Biology 3, American Heart Association |
07/2013 Reviewer, Fellowships: Physiology and Pathobiology of Cardiovascular and Respiratory Systems, NIH ZRG1 F10A (20) NRSA, National Institutes of Health |
10/2013 Reviewer, Regenerative Cell Biology 1, American Heart Association |
11/2013 Reviewer, Fellowships: Physiology and Pathobiology of Cardiovascular and Respiratory Systems, NIH ZRG1 F10A (20) NRSA, National Institutes of Health |
03/2014 Reviewer, Fellowships: Physiology and Pathobiology of Cardiovascular and Respiratory Systems, NIH ZRG1 F10A (20) NRSA, National Institutes of Health |
04/2014 Reviewer, Regenerative Cell Biology 1, American Heart Association |
10/2014 Reviewer, Regenerative Cell Biology 1, American Heart Association |
04/2015 Reviewer, Regenerative Cell Biology 1, American Heart Association |
07/2015 Reviewer, Fellowships: Physiology and Pathobiology of Cardiovascular and Respiratory Systems, NIH ZRG1 F10A (20) NRSA, National Institutes of Health |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Laboratory of Molecular Biology, Division of Neuroscience, Medical Research Council Centre, Cambridge, England, 1993 |
National |
Division on Aging, Harvard Medical School, Boston, MA, 1996 |
University of Miami School of Medicine, Geriatric Research Education and Clinical Center, VA Medical Center and Department of Medicine, Miami, FL, 1999 |
Hospital for Special Surgery, New York, NY, 1999 |
Department of Neuroscience, Johns Hopkins University Medical School, Baltimore, MD, 2001 |
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AK, 2003 |
Platform Presentation, Weinstein Cardiovascular Conferences, Tuscon, AZ, 2005 |
Department of Cell Biology, University of North Carolina, Chapel Hill, NC, 2006 |
Robert Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, 2007 |
2008 South Dakota Conference on Early Cardiac Development, Keystone, SD, 2008 |
Department of Pathology, University of California-Irvine, Irvine, CA, 2010 |
Department of Geriatrics, University of Arkansas Medical School, Little Rock, AK, 2012 |
Regional |
Chemistry Department, University of Michigan-Flint, Flint, MI, 2003 |
Department of Biology, University of Wisconsin- Platteville, Platteville, WI, 2004 |
Department of Molecular Medicine, University of Chicago, Chicago, IL, 2004 |
Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI, 2005 |
Riley Heart Center Symposium, Indianapolis, IN, 2009 |
Local |
MCW, Department of Cell Biology, Neurobiology & Anatomy, Milwaukee, WI, 2005 |
Children's Research Institute, Department of Pediatrics, Milwaukee, WI, 2009 |
MCW, Department of Cell Biology, Neurobiology & Anatomy, Milwaukee, WI, 2009 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
1994 - 1995 Member, Research Work Group Subcommittee, Integrated Academic Information Management System (IAIMS) Implementation, Medical College of Wisconsin |
1995 - 2005 Founder and Coordinator, Signaling And Gene Expression (SAGE) Working Group, Cancer Center, Medical College of Wisconsin |
1996 - 2005 Member, Neurosciences Graduate Program Steering Committee, Graduate School, Medical College of Wisconsin |
1996 - 1999 Member, Graduate Student Awards Committee, Graduate School, Medical College of Wisconsin |
1997 - 2003 Member, Biochemistry Graduate Studies Committee, Department of Biochemistry, Medical College of Wisconsin |
1998 - 2002 Member, Faculty Search Committee/Molecular Biology, Biochemistry Department, Medical College of Wisconsin |
1998 - 2001 Member, Graduate Student Admission & Welfare Committee, Graduate School, Medical College of Wisconsin |
1998 - 1999 Member, Ad Hoc Graduate Curriculum Re-design Committee, Graduate School, Medical College of Wisconsin |
1998 - 2005 Member, Research Grants Committee, Cancer Center, Medical College of Wisconsin |
1999 - 2003 Member, Institutional Animal Care and Use Committee, Medical College of Wisconsin |
1999 - 2003 Biochemistry Representative, Graduate Studies Council, Graduate School, Medical College of Wisconsin |
1999 - 2001 Member, Recruitment Committee, Interdisciplinary Biomedical Graduate Program, Graduate School, Medical College of Wisconsin |
1999 - 2009 Member, Graduate Admissions Committee, Interdisciplinary Biomedical Graduate Program (IDP), Graduate School, Medical College of Wisconsin |
2000 - 2001 Chairman, Nominating Committee, Graduate School, Medical College of Wisconsin |
2001 - 2004 Member, Nominating Committee, Medical College of Wisconsin |
2001 - 2003 Advisor, Graduate Program, Department of Biochemistry, Medical College of Wisconsin |
2002 - 2007 Chair, Stipend Allocation Committee, Ad hoc GSC, Medical College of Wisconsin |
2002 - 2003 Member, Joint Search, Micro. & Mol. Genetics Dept/Human & Mol Genetics, Medical College of Wisconsin |
2002 - 2005 Chair, Admissions Committee, IDP Graduate, Medical College of Wisconsin |
2002 - 2005 Interim Leader, Cancer Center Program: Signaling and Gene Expression, Medical College of Wisconsin |
2003 - 2006 Member, Research and Affairs Committee, Medical College of Wisconsin |
2003 - Present Representative, Interdisciplinary Program in Biomedical Sciences, Graduate Studies Council, Medical College of Wisconsin |
2003 - 2006 Representative, Faculty Council, Biochemistry Department, Medical College of Wisconsin |
2003 - 2006 Chair, Nominations Committee, Cancer Center "Distinguished Speakers in Basic Cancer Research" Series, Medical College of Wisconsin |
2003 - 2005 Member, Credentials Committee, Graduate School Faculty, Medical College of Wisconsin |
2004 - Present Member, Assessment Committee, Graduate School Student, Medical College of Wisconsin |
2004 - 2005 Member, Center Search Committee, Human and Molecular Genetics, Medical College of Wisconsin |
2004 - 2006 Member, Faculty Search Committee, Biochemistry Department, Medical College of Wisconsin |
2005 - Present Member, Joint Cancer Search Committee, MCW Interdepartmental, Medical College of Wisconsin |
2005 - Present Ad hoc Reviewer, Grants Committee, Cancer Center, Medical College of Wisconsin |
2006 - Present Member, BRC Advisory Committee, Medical College of Wisconsin |
2006 - Present Chair, MCW IACUC, Medical College of Wisconsin |
2006 - Present Ad hoc Reviewer, Grant Committee, Children's Institute, Medical College of Wisconsin |
2007 - Present Member, Steering Committee, Program in Regenerative Medicine, Medical College of Wisconsin |
2007 - 2010 Member, Safety Committee, Medical College of Wisconsin |
2007 - Present Chair, Curriculum Committee, Interdisciplinary Biomedical Graduate Program, Medical College of Wisconsin |
2008 - Present Member, Medicine Faculty Search Committee, Cell Biology/Regenerative, Medical College of Wisconsin |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Muench, K.F., Misra, R.P. and Humayun, M.Z. Sequence specificity in aflatoxin B1 DNA interactions. Proc. Natl. Acad. Sci. USA 80:6-10. 1983. |
2. Misra, R.P., Muench, K.F. and Humayun, M.Z. Covalent and noncovalent interactions of aflatoxin with defined deoxyribonucleic acid sequences. Biochemistry 22:3351-3359, 1983. |
3. DiGiovanni, L., Haynes, S.R., Misra, R. and Jelinek, W.R. Kpn I family of long-dispersed repeated DNA sequences of man: Evidence for entry into genomic DNA of DNA copies of poly(A) terminated Kpn I RNAs. Proc. Natl. Acad. Sci. USA 80:6533-6537, 1983. |
4. Paulson, K.E., Deka, N., Schmid, C.W., Misra, R., Schindler, C.W., Rush, M.G., Kadyk, L. and Leinwand, L. A transposon-like element in human DNA. Nature 316:359-361, 1985. |
5. Misra, R., Shih, A., Rush, M., Wong, E. and Schmid, C.W. Cloned extrachromosomal circular DNA copies of the human transposable element THE-1 are related predominantly to a single type of family member. J. Mol. Biol. 196:233-243, 1987. |
6. Shih, A., Misra, R. and Rush, M.G. Detection of multiple, novel reverse transcriptase coding sequences in human nucleic acids: Relation to primate retroviruses. J. Virology 63:64-75, 1989. |
7. Misra, R., Matera, A.G., Schmid, C.W. and Rush, M.G. Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1. Nucleic Acids Res. 17:8327-8341, 1989. |
8. Hazel, T.G., Misra, R., Davis, I.J., Greenberg, M.E. and Lau, L.F. Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Mol. Cell. Biol. 11:3239 3246, 1991. |
9. Misra, R., Rivera, V.M., Wang, J.M., Fan, P-D., and Greenberg, M.E. The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts. Mol. Cell. Biol. 11:4545-4554, 1991. |
10. Rivera, V.M., Miranti, C.K., Misra, R.P., Ginty, D.D., Chen, R.-H., Blenis, J., and Greenberg, M.E. A growth-factor induced kinase phosphorylates the serum response factor at a site that regulates its DNA binding activity. Mol. Cell. Biol. 13:6260-6273, 1993. |
11. Misra, R.P., Bonni, A., Miranti, C.K., Rivera, V.M., Sheng, M., and Greenberg, M.E. L-type voltage sensitive calcium channel activation stimulates gene expression by a serum response factor dependent pathway. J. Biol. Chem. 269:25483-25493, 1994. |
12. Spencer, J.A., and Misra, R.P. Expression of the serum response factor gene is regulated by serum response factor binding sites. J. Biol. Chem. 271:16535-16543, 1996. |
13. Nair, D., Misra, R.P., Sallis, J.D., and Cheung, H.S. Phosphocitrate inhibits a basic calcium phosphate and calcium pyrophosphate dihydrate crystal-induced mitogen activated-protein kinase cascade signal transduction pathway. J. Biol. Chem. 272:18920-18925, 1997. |
14. Ganesan, A.K., Frank, D.W., Misra, R.P., Schmidt, G. and Barbieri, J.T. Pseudomonas aeruginosa Exoenzyme S ADP-ribosylates Ras at multiple sites. J. Biol. Chem. 273: 7332-7337, 1998. |
15. Spencer, J.A., Major, M., and Misra, R.P. Basic fibroblast growth factor activates serum response factor gene expression by multiple distinct signaling mechanisms. Mol. Cell Biol. 19:3977-3988, 1999. |
16. Spencer, J.A., and Misra, R.P. Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated mechanism in response to serum growth signals. Oncogene, 18:7319-7329, 1999. |
17. Miano, J., Carlson, L., Spencer, J.A., and Misra, R.P. Serum Response Factor-dependent regulation of the smooth muscle calponin gene, J. Biol. Chem. 275:9814-9822, 2000. |
18. Zhang, X. M., Azhar, G., Chai, J., Sheridan, P., Nagano, K., Brown, T., Yang, J. H., Khrapko, K., Borras, A. M., Lawitts, J., Misra, R. P., and Wei, J. Y. Cardiomyopathy in transgenic mice with cardiac-specific overexpression of the serum response factor, Amer. J. Physiol. 280:H1782-H1792, 2001. |
19. Zhang, X. M., Chai, Azhar, G.,J., Sheridan, P., Brown, J. H., Khrapko, K., Borras, A. M., Lawitts, J., Misra, R. P., and Wei, J. Y. Early onset of cardiomyopathy in transgenic mice overexpressing a mutant form of serum response factor. J. Biol. Chem. 276:40033-40040, 2001. |
20. Misra, R.P., Bronson, S.K., Xiao, Q., Garrison, W., Li, J., Zhao, R., and Duncan, S.A. Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid complementation, BioMedCentral Biotechnology 1:12, 2001. |
21. Sun, Y, Wenger, L., Brinckerhoff, C.E., Misra, R.P. , and H.S. Cheung, H.S. BCP crystals induce metalloproteinase (MMP)-1 expression through Ras/MEK1/SRF/c-FOS/AP-1/MMP-1 Pathway: Involvement of Transcription Factor Binding Sites PEA-3 and AP-1,J. Biol. Chem. 277:1544-1552, 2002. |
22. Nelson, T.J, Duncan, S.A., and Misra, R.P., A Conserved Enhancer in the Serum Response Factor Promoter Controls Expression During Early Coronary Vasculogenesis, Circulation Research 94:1059-1066, 2004. |
23. Miano, J.M, Ramanan, N.,Georger, M.A., De Mesy Bentley, K.L., Emerson, R.L., Balza, R.O., Xiao, Q., Weiler, H., Gintly, D.D., and Misra, R.P., Restricted inactivation of serum response factor to the cardiovascular system. Proc. Natnl. Acad,Sci. USA, 101:17132-17137, 2004 |
24. Nelson, T.J., Balza, R.O, Xiao, Q., and Misra, R.P., SRF-dependent gene expression in isolated cardiomyocytes: regulation of genes involved in cardiac hypertrophy. J Mol. Cell. Cardiology, 39:479-489, 2005. |
25. Balza, R., and Misra R.P., Serum Response Factor is required for contractile apparatus gene expression and maintenance of sarcomeric integrity in cardiomyocytes. J. Biol. Chem. 281:6498-6510, 2006. |
26. Nelson, T.J., Ge, Z-D, Van Orman, J., Barron, M, Rudy-Reil, D., Hacker, T.A., Misra, R., Auchampach, J., Lough, J. , Improved Cardiac Function in Infarcted Mice after Treatment with Pluripotent Embryonic Stem Cells, Anatomical Records A, 288:1216-1224, 2006. |
27. Major, M.L., Cheung, H.S., and Misra, R. P., Basic Calcium Phosphate Crystals Activate c-fos Gene Expression Through a Ras/ERK Dependent Signaling Mechanism, Biochem, Biophys. Res.Comm 355:654-660, 2007. |
28. Holtz, M.L. and Misra, R.P., Endothelial-specific ablation of Serum Response Factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality, BMC Developmental Biology, 8:65, 2008. |
29. Sun, K, Battle, M., Misra, R.P., and Duncan, S.A., Hepatocyte expression of Serum Response Factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. Hepataology, 49:490-501, 2009. |
30. Holtz, M.L. and Misra, R.P. , Serum Response Factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium, BMC Developmental Biology, 8:65, 2011. |
31. Cossette, S.C. and Misra, R.P., The Identification of different endothelial cell populations within the mouse proepicardium, Developmental Dynamics, 240:2344, 2011. |
32. Kolander, K, Cossette, S., Duncan, S.A. and Misra, R.P. Epicardial GATA factors regulate early coronary vascular plexus formation, Developmental Biology, 386:204, 2014. |
Books, Chapters, and Reviews |
1. Misra, R.P., Greenberg, M.E., and Bading, H., Mechanisms of c-fos Transcriptional Regulation by Growth Factors and Membrane Depolarization, Ninth International Congress on Endocrinology, Nice, France, 1993. |
2. Misra, R.P., Growth Factor Regulation of c-fos Proto-oncogene Transcription, in Proto-oncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation, Khan, S.A. and Stancel, G.M., Eds., CRC Press, 1994. |
3. Misra, R.P., Calcium Crystal Mediated Cell Activation Pathways, in Cellular and Molecular Life Sciences , 57:421-428, 2000, invited review . |
4. Misra, R.P. and Duncan, S.A., Gene Targeting in the Mouse: Advances in introduction of transgenes into the genome by homologous recombination, in Endocrine Journal, 19:229-238, 2002, invited review. |
5. Rush, M.G. and Misra, R. Extrachromosomal DNA in eukaryotes. Plasmid 14:177-191, 1985. |
6. Misra, R.P., The Role of Serum Response Factor in Early Coronary Vasculogenesis, in Pediatric Cardiology, 31:400-407, 2010. invited review. |
7. Misra, R.P., Greenberg, M.E., and Bading, H., Mechanisms of c-fos Transcriptional Regulation by Growth Factors and Membrane Depolarization, Ninth International Congress on Endocrinology, Nice, France, 1993. |
8. Misra, R.P., Growth Factor Regulation of c-fos Proto-oncogene Transcription, in Proto-oncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation, Khan, S.A. and Stancel, G.M., Eds., CRC Press, 1994. |
9. Misra, R.P., Calcium Crystal Mediated Cell Activation Pathways, in Cellular and Molecular Life Sciences , 57:421-428, 2000, invited review . |
10. Misra, R.P. and Duncan, S.A., Gene Targeting in the Mouse: Advances in introduction of transgenes into the genome by homologous recombination, in Endocrine Journal, 19:229-238, 2002, invited review. |
11. Misra, R.P., The Role of Serum Response Factor in Early Coronary Vasculogenesis, in Pediatric Cardiology, 31:400-407, 2010. invited review. |
Abstracts |
1. S. Hendrickson, A. Bonni, C.K. Miranti, M.E. Greenberg, and R.P. Misra, 'Elevated Intracellular Calcium Levels can Activate SRF-dependent Transcription and Phosphorylation,' Hormone Action Gordon Conference, Kimball Union Academy, Meriden, N.H., July 1995. |
2. R.P. Misra and J.A. Spencer, 'Regulation of Serum Response Factor Gene Expression by Extracellular Signals,' Cell Proliferation Gordon Conference, Colby Sawyer College, New London, N.H., July 1997. |
3. R.P. Misra, M.L. Major, and H.S. Cheung, 'Molecular Mechanism of Cell Activation by Calcium Containing Crystals,' American Federation of Aging Research Foundation Grantee Conference, Arden House, Harriman, N.Y., June 1998. |
4. J.A. Spencer, M.L. Major, R.P. Misra, 'bFGF Activates Serum Response Factor Gene Expression by Multiple Distinct Mechanisms,' won at the Hormone Action Gordon, Kimball Union Academy, Meriden, N.H., July 1998. Won poster award. |
5. R.P. Misra, M.L. Major, and J.A. Spencer, 'Regulation of Serum Response Factor Gene Expression by Extracellular Signals, Cell Proliferation Gordon Conference,' Colby Sawyer College, New London, N.H., July 1999. |
6. Y. Sun, L. Wenger, C.E. Brinckerhoff, R. P. Misra , and H.S. Cheung, 'BCP Crystals Induce Metalloproteinase (MMP)-1 Expression Through the Signal Transduction Pathway of RAS/ERK 1 & 2 MAPK /SRE/c-FOS/AP-1/hMMP-1,' Annual National Scientific Meeting of American College of Rheumatology, Boston, MA, 1999. |
7. X. Zhang, G. Azhar, J. Chai, P. Sheridan, K. Nagano, T. Brown, J. Yang, K. Khrapko, A.M. Borras, J. Lawitts, R.P. Misra, J.Y. Wei, 'Early Onset of Dilated Cardiomyopathy in Transgenic Mice Expressing a Mutant Form of Serum Response Factor,' Molecular, Cellular, and Integrated Physiological Approaches to the Failing Heart, Salt Lake City, Utah, August, 1999. |
8. X. Zhang, G. Azhar, J. Chai, P. Sheridan, K. Nagano, T. Brown, J. Yang, K. Khrapko, A.M. Borras, J. Lawitts, R.P. Misra, J.Y. Wei, 'Cardiac Hypertrophy in Transgenic Mice Overexpressing Serum Response Factor,' American Heart Association 72nd Scientific Sessions, Atlanta, Georgia, November, 1999. |
9. T.J. Nelson, S.A. Duncan, J. Lough, and R. P. Misra, 'Distal 5' Promoter Elements Control In Vivo SRF Gene Expression in the Proepicardial Organ,' American Heart Association 75th Scientific Sessions, Chicago, Illinois, November, 2002. |
10. T.J. Nelson, S.A. Duncan, J. Lough, and R. P. Misra, 'SRF Gene Expression in the Proepicardial Organ is Regulated through an conserved E-box dependent module in the proximal promoter during Coronary Vascular genesis' Weinstein Cardiovascular Development Conference, Boston, MA, May 2003. (Platform Talk) |
11. T.J. Nelson, S.A. Duncan, J. Lough, and R. P. Misra, 'During Coronary Vasculogenesis Expression of Serum Response Factor is Regulated by an E-box-Dependent Module in the Proximal Promoter,' Molecular Mechanisms of Growth, Death, and Regeneration in the Myocardium: Basic Biology and Insights into Ischemic Heart Disease and Heart Failure, American Heart Association Conference, Snowbird, UT, August 2003. |
12. Holtz, M.L., and Misra, R.P., 'Control of Coronary Vascular Gene Expression during Early Development: Conditional Gene Ablation in the Proepicardium' Weinstein Cardiovascular Development Conference, Tampa Bay, FL May 2006. |
13. Development: Conditional Gene Ablation in the Proepicardium' Weinstein Cardiovascular Development Conference, Tampa Bay, FL May 2006. |
14. Holtz, M.L., and Misra, R.P. 'Endothelial-Specific Ablation of Serum Response Factor Results in Vascular Instability and Embryonic Lethality' Weinstein Cardiovascular Development Conference, Indianapolis, IN, May 2007. (Platform Talk M.L. Holtz) |
15. Cossette, S. M., Holtz, M.L., and Misra, R. P. 'Conditional Ablation of a Subset of Cells of the Proepicardium' Weinstein Cardiovascular Development Conference, Indianapolis, IN, May 2007. (Travel Award to S. Cossette) |
16. Cossette, S. M., Beres, A.J., and Misra, R. P. 'In vitro Analysis of Mouse Coronary Vasculogenesis' Weinstein Cardiovascular Development Conference, Houston, TX, May 2008. |
17. Cossette, S. M. and Misra, R. P. 'In vitro Analysis of Mouse Coronary Proepicardium' Weinstein Cardiovascular Development Conference, San Francisco, CA, May 2009. |
18. Cossette, S. M. and Misra, R. P. 'The Identification of Different Endothelial Cell Populations within the Mouse Proepicardium" Weinstein Cardiovascular Development Conference, Cincinnati, OH, May 2011. |
19. Kolander K.D., Holtz, M.L. and Misra, R. P. 'Epicardial GATA Factors are required for Coronary Endothelial Plexus Formation" Weinstein Cardiovascular Development Conference, Cincinnati, OH, May 2011. |
20. Kolander K.D., Holtz, M.L. and Misra, R. P "Epicardial GATA Factors Regulate Coronary Endothelial Migration Via SHH signaling,' Weinstein Cardiovascular Development Conference, Chicago, IL, May 2012. |
