CURRICULUM VITAE
Ronald Blake Hill PhD
Ronald Blake Hill PhD
Professor
Department of Biochemistry
Department of Biochemistry
OFFICE ADDRESS: |
Translational and Biomedical Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
09/1980 - 06/1984 B.A., Kalamazoo College, Kalamazoo, MI |
09/1987 - 04/1995 Ph.D., Yale University, New Haven, CT |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
05/1995 - 06/2000 Postdoctoral Fellow, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylanvia, 3700 Hamilton Walk, Philadelphia, PA 19104-6059 |
FACULTY APPOINTMENTS: |
07/2000 - 07/2006 Assistant Professor, Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
07/2006 - 07/2012 Associate Professor, Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
08/2012 - Present Professor, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
09/2000 - 07/2012 Preceptor, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Molecular Biophysics Graduate Training Program, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
09/2000 - 07/2012 Preceptor, Zanvyl Krieger School of Arts & Sciences, Molecular, Developmental Biology and Biophysics Graduate Training Program, Johns Hopkins University, 3520 San Martin Drive, Carnegie Institution for Science, Department of Embryology, Baltimore, MD 21218 |
01/2004 - 09/2005 Co-Founder, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Chemical Biology Graduate Training Program, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
09/2005 - 07/2012 Preceptor, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Chemical Biology Graduate Training Program, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
09/2005 - 07/2012 Member, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
09/2012 - Present Preceptor, Medical Scientist Training Program, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 |
09/2012 - Present Preceptor, Interdisciplinary Program in Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
01/2001 - 03/2012 Lead Scientist, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Design of Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
01/2002 - 12/2002 Lead Scientist, Zanvyl Krieger School of Arts & Sciences, Design and Construction of Temporary NMR Space, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
01/2002 - 09/2004 Lead Scientist, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Construction of Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
01/2004 - 07/2012 Co-Director, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
12/2004 - 06/2006 Lead Negotiator, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Failed 800 MHz NMR Instruments Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
12/2010 - 07/2012 Member, Zanvyl Krieger School of Arts & Sciences, Research Infrastructure Committee, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 |
AWARDS AND HONORS: |
09/1980 - 06/1984 Honors Scholarship, Kalamazoo College |
09/1987 - 06/1992 Frederick S. Heyl Doctoral Fellowship, Yale University |
09/1989 - 05/1995 Graduate Fellow, Calhoun College, Yale University |
09/1996 - 08/1998 NIH - NRSA Postdoctoral Fellowship |
09/1998 - 06/2000 George W. Raiziss Postdoctoral Fellow, University of Pennsylvania |
09/2007 - 05/2007 Excellence in Teaching Award Nominee, Johns Hopkins |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
American Association for the Advancement of Science |
American Chemical Society |
Protein Society |
Biophysical Society |
American Society for Biochemistry and Molecular Biology |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
BBA-Membranes |
Biochemistry |
Cell Death and Differentiation |
Chemical Reviews |
European Journal of Biophysics |
FEBS Letters Journal of American Chemical Society |
Journal of Biological Chemistry |
Journal of Cellular Biochemistry, |
Journal of Cellular and Molecular Medicine |
Journal of Cell Science |
Journal of Molecular Biology |
PLOS One |
Protein Engineering Design and Selection |
Protein Science |
Proteins |
PNAS |
Protein & Peptide Letters |
Nature Structural & Molecular Biology |
Analytical Biochemistry |
Biophysical Journal |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2002 - Present Member, Mentoring Committee, Protein Society |
2003 - 2005 Ad Hoc Reviewer, International Science & Technology Center |
06/2004 Ad Hoc Reviewer, Special Emphasis Study Section ZRG1, National Institutes of Health |
07/2004 Panel Member, University Education, Protein Society Annual Symposium |
06/2006 Ad Hoc Reviewer, Study Section, S10 SIG, National Institutes of Health |
2006 - 2011 Chair, Mentoring Committee, Protein Society |
2007 - 2010 Ad Hoc Reviewer, individual investigator/CAREER awards, National Science Foundation |
02/2008 Ad Hoc Reviewer, Study Section, Molecular Structure and Function B, National Institutes of Health |
2008 - 2011 Member, Membership Committee, Protein Society |
02/2009 Ad Hoc Reviewer, Study Section, S10 SIG, National Institutes of Health |
2009 Ad Hoc Reviewer, ARRA awards, National Institutes of Health |
2010 Ad Hoc Reviewer, National Research Foundation, Thuthuka Program, South Africa |
06/2011 Ad Hoc Reviewer, Study Section, S10 SIG (declined), National Institutes of Health |
2011 Ad Hoc Reviewer, Director’s Early Independence Award (DP5), National Institutes of Health |
2011 Ad Hoc Reviewer, National Research Foundation, South Africa |
2012 Ad Hoc Reviewer, Medical Research Council, United Kingdom |
2012 Ad Hoc Reviewer, Bioinformatics and Genetics Pilot Project Program, South Carolina INBRE |
10/2013 Ad Hoc Reviewer, Study Section, Biochemistry and Biophysics of Membranes, National Institutes of Health |
2013 - Present Member, Publications Committee, American Society for Biochemistry and Molecular Biology |
02/2014 Ad Hoc Reviewer, Study Section, Biochemistry and Biophysics of Membranes, National Institutes of Health |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Invited Speaker, Johns Hopkins School of Medicine, Department of Biological Chemistry, Baltimore, MD, 2001 |
Invited Speaker, Johns Hopkins Bloomberg School of Public Health, Department of Molecular Biology & Biochemistry, Baltimore, MD, 2004 |
Invited Speaker, Milwaukee Area Structural Biology Interest Group, Milwaukee, WI, 2013 |
National |
Endocrine Society 68th Annual Meeting, Anaheim, CA, 1986 |
Frontiers of NMR in Molecular Biology III, Keystone Symposium, Taos, NM, 1993 |
Invited Speaker, Proctor & Gamble, Cincinnati, OH, 1994 |
35th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 1994 |
Invited Speaker, Genetics Institute, Cambridge, MA, 1994 |
37th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 1996 |
18th International Conference on Magnetic Resonance in Biological Systems, Keystone, CO, 1996 |
Invited Speaker, University of Utah, Department of Chemistry, Salt Lake City, UT, 1999 |
Invited Speaker, Kalamazoo College, Department of Chemistry, Kalamazoo, MI, 1999 |
Invited Speaker, Center for Advanced Research in Biotechnology, Rockville, MD, 1999 |
Invited Speaker, Bioorganic Chemistry Gordon Conference, Proctor Academy, Andover, NH, 1999 |
Invited Speaker, Dartmouth College, Department of Chemistry, Hanover, NH, 1999 |
Invited Speaker, University of Maryland, Department of Chemistry and Biochemistry, College Park, MD, 1999 |
Invited Speaker, Johns Hopkins University, Department of Biology, Baltimore, MD, 2000 |
41st Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 2000 |
Invited Speaker, niversity of Illinois at Chicago, Department of Chemistry, Chicago, IL, 2000 |
Invited Speaker, Albert Einstein College of Medicine, Department of Biophysics, Bronx, NY, 2000 |
14th Gibbs Conference in Biological Thermodynamics, Carbondale, IL, 2000 |
6th Johns Hopkins Folding Meeting, Berkeley Springs, WV, 2001 |
Cold Spring Harbor Meeting on Cell Death, Cold Spring Harbor Lab, NY, 2001 |
7th Johns Hopkins Folding Meeting, Berkeley Springs, WV, 2003 |
Invited Speaker, Columbia University School of Medicine, Biophysics and Biochemistry, New York, NY, 2003 |
Invited Speaker, Kalamazoo College, Department of Chemistry, Kalamazoo, MI, 2004 |
Mitochondria and Chloroplasts Gordon Conference, Kimball Union Academy, Meriden, NH, 2004 |
45th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 2004 |
48th Annual Meeting, Biophysical Society, Baltimore, MD, 2004 |
Invited Speaker, City College of New York, Department of Chemistry and Biochemistry, New York, NY, 2005 |
Invited Speaker, NMR Recent Developments in Magnetic Resonance: Liquid and Solid State Applications, Theoretical Methodology, and Emerging Techniques, Division of Physical Chemistry, 229th American Chemical Society National Meeting, San Diego, CA, 2005 |
20th Annual Symposium, Protein Society, San Diego, CA, 2006 |
Frontiers in Structural Biology, Keystone Symposium, Keystone, CO, 2006 |
Invited Speaker, University of Maryland, Biophysics Program, College Park, MD, 2006 |
Invited Speaker, Cell Death Gordon Research Conference, Big Sky, MT, 2006 |
Invited Speaker, Emory University, Department of Chemistry, Atlanta, GA, 2006 |
Interactions of Peptides and Proteins with Membrane Surfaces, 231st American Chemical Society National Meeting, Division of Physical Chemistry, Atlanta, GA, 2006 |
Invited Speaker, Summit on Facilities for Emerging Sciences, St. Petersburg, FL, 2006 |
Invited Speaker, Biennial Biomolecular NMR Symposium, Center for Advanced Research in Biotechnology, Rockville, MD, 2006 |
Invited Speaker, University of Massachusetts Medical School, Department of Biochemistry & Molecular Pharmacology, Worcester, MA, 2006 |
Invited Speaker, Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, MD, 2006 |
Salon des Refusés Platform Session on Bcl-2 Proteins (with Dr. Marco Colombini), Biophysical Society Annual Meeting, Baltimore, MD, 2007 |
21st Annual Symposium, Protein Society, Boston, MA, 2007 |
Assembly of the Mitochondrial Respiratory Chain, FASEB Summer Research Conference, Tucson, AZ, 2007 |
Invited Speaker, University of Indiana, Department of Chemistry & Biochemistry, Bloomington, IN, 2007 |
Invited Speaker, Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 2008 |
Invited Speaker, Structure, Property, and Function of Cell Membranes and Membrane Related Biomolecule, 235th American Chemical Society National Meeting, Division of Colloid & Surface Chemistry, New Orleans, LA, 2008 |
22nd Annual Symposium, Protein Society, San Diego, CA, 2008 |
Mitochondrial Physiology and Pathobiology, Charleston, SC, 2009 |
Invited Speaker, St. Jude Children's Research Hospital, Memphis, TN, 2009 |
Session Chair, 23rd Annual Symposium, Protein Society, Boston, MA, 2009 |
50th Annual Meeting, American Society for Cell Biology, Philadelphia, PA, 2010 |
Invited Speaker, University of California Skaggs School of Pharmacy, San Diego, CA, 2010 |
Invited Speaker, University of California, Department of Chemistry & Biochemistry, Santa Barbara, CA, 2010 |
Invited Speaker, Burnham Institute, San Diego, CA, 2010 |
24th Annual Symposium, Protein Society, San Diego, CA, 2010 |
Invited Speaker, Cornell University Weil School of Medicine, Department of Biochemistry, New York, NY, 2010 |
Invited Speaker, University of California, Department of Chemistry and Biochemistry, Irvine, CA, 2010 |
Invited Speaker, University of California, Department of Chemistry, San Diego, CA, 2010 |
Molecular Basis for Biological Membrane Organization and Dynamics, Keystone Symposium, Snowbird, UT, 2010 |
55th Annual Meeting, Biophysical Society, Baltimore, MD, 2011 |
Invited Speaker, Mitochondrial Assembly & Dynamics in Health, Disease & Aging, FASEB Summer Research Conference, Steamboat, CO, 2011 |
Invited Speaker, 25th Annual Symposium, Protein Society, Boston, MA, 2011 |
Invited Speaker, Proteins Gordon Research Conference, Holderness School, Holderness, NH, 2011 |
Invited Speaker, University of Maryland School of Medicine, Department of Biochemistry, Baltimore, MD, 2011 |
Invited Speaker, Texas A&M University, Department of Biochemistry, College Station, TX, 2012 |
Invited Speaker, University of Illinois School of Medicine, Department of Physiology, Chicago, IL, 2012 |
Invited Speaker, Institute for Marine and Environmental Technology, University of Maryland, Baltimore, MD, 2012 |
Invited Speaker, University of Maryland Baltimore County, Department of Biology, Catonsville, MD, 2012 |
Invited Speaker, Boston Biomedical Research Institute, Boston, MA, 2012 |
Invited Speaker, University of Colorado Health Sciences, Department of Biochemistry, Aurora, CO, 2012 |
Co-Chair, Protein Conformation Platform Session, 56th Annual Meeting, Biophysical Society, San Diego, CA, 2012 |
Invited Speaker, University of Houston, Department of Biology and Biochemistry, Houston, TX, 2012 |
Invited Speaker, University of Maryland School of Medicine, Department of Biochemistry, Baltimore, MD, 2012 |
Invited Speaker, Boston University Medical Center, Department of Biophysics and Physiology, Boston, MA, 2012 |
Invited Speaker, University of Pittsburgh School of Medicine, Department of Structural Biology, Pittsburgh, PA, 2012 |
Invited Speaker, Biomolecular Interactions and Methods Gordon Research Conference, Galveston,TX, 2012 |
Invited Speaker, University of Medicine and Dentistry of New Jersey, Department of Cell Biology, Piscataway, NJ, 2012 |
Invited Speaker, Biomolecular Structure, Dynamics, and Function: Membrane Proteins, Vanderbilt University, Nashville, TN, 2014 |
Invited Speaker, Emerging Roles of Mitochondria in Cell Signaling, Physiology and Disease, ASBMB Annual Meeting, San Diego, CA, 2014 |
Biomolecular Structure, Dynamics, and Function 1 (with Drs. Kevin Gardner and Richard Kriwacki), Memphis, TN |
International |
Mitochondria and Chloroplasts Gordon Conference, Oxford University, Oxford, England, 2006 |
Invited Speaker, 7th European School of Haematolog International Euroconference on Mechanisms of Cell Death & Disease: Advances in Therapeutic Intervention and Drug Development, Cascais, Portugal, 2008 |
Session Chair, Mitochondrial Dynamics: from Mechanism to Disease, Sardinia, Italy, 2011 |
CNRS, Centre de Biochimie Structurale, Montpellier, France, 2011 |
The Institute of Cancer Research, Division of Structural Biology, London, England, 2011 |
Invited Speaker, 5th International Congress on Stress Responses in Biology and Medicine, Quebec City, Quebec, Canada, 2011 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2001 - 2002 Member, Faculty Search Committee, Department of Chemistry, Johns Hopkins University |
2001 - 2002 Member, Howard Hughes Medical Institute Summer Undergraduate Research Fellowship Selection Committee, Johns Hopkins University |
2001 - 2003 Member, Seminar Committee, Department of Biology, Johns Hopkins University |
2001 - 2002 Member, Howard Hughes Medical Institute Summer Undergraduate Research Fellowship Selection Committee, Johns Hopkins University |
2001 - 2005 Zanvyl Krieger School of Arts and Sciences Representative, Graduate Board, Johns Hopkins University |
2002 - 2006 Meyerhoff Mentor, Meyerhoff Scholar Program, University of Maryland Baltimore County |
2002 - 2003 Principle Investigator, Acquisition and Installation of two 600 MHz NMR instruments, Johns Hopkins University |
2002 - 2004 Member, Retreat Organizing Committee, Cellular, Molecular, Developmental Biology, and Biophysics Graduate Training Program, Johns Hopkins University |
2003 Poster Judge, 6th Annual Symposium Undergraduate Research Symposium |
2003 Member, Facility Manager Search Committee, Biomedical NMR Center, Johns Hopkins University |
2004 - 2007 Chair, Seminar Committee, Department of Biology, Johns Hopkins University |
2005 - 2011 Member, Health Professions Committee, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
2005 - 2008 Member, Retreat Organizing Committee, Cellular, Molecular, Developmental Biology, and Biophysics Graduate Training Program, Johns Hopkins University |
2005 - 2008 Member, Steering Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
2005 - 2008 Member, Curriculum Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
2005 - 2011 Member, Advising Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
2005 - 2008 Member, Admissions Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
2006 Mentor, Research Practicum, Baltimore Polytechnic Institute |
2008 Member, Director Search Committee, Postbaccalaureate Medical Education Program, Johns Hopkins University |
2008 - 2010 Member, Curriculum Committee, Department of Biology, Johns Hopkins University |
2008 - 2009 Member, Faculty Search Committee, Department of Biology, Johns Hopkins University |
2009 - 2010 Member, Faculty Search Committee, Department of Biology, Johns Hopkins University |
2010 - 2011 Member, Summer Undergraduate Fellowship Selection Committee, Institute for NanoBioTechnology, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Medical Student Education |
2012 - Present Case-Based Discussions, Molecules To Cells, M1 Core Course , ~20 students, 3 cases |
2013 - Present Molecules To Cells, M1 Core Course, ~210 students, 3 lectures |
EXTRAMURAL TEACHING: |
Continuing Medical Education |
2008 Johns Hopkins University, Biological Impacts of Climate Change, "Alumni College", ~50 alumni, 1 lecture |
Graduate Student Education |
2001 - 2012 Johns Hopkins University, Department of Biology, Research Problems in Biology 020.513, 1-5 students/yr (undergraduate) |
2001 - 2010 Johns Hopkins University, Department of Biology, Biochemistry 020.305, 400-475 students/yr, 18-26 lectures/yr (undergraduate) |
2002 Johns Hopkins University, Department of Biophysics, Introduction to Biomedical Research & Careers 025.106 21 students, 1 lecture and dinner (undergraduate) |
2002 United States Naval Academy, Annapolis, MD, Department of Chemistry & Biochemistry, Biochemistry, ~20 cadets, 1 lecture (undergraduate) |
2002 - 2012 Johns Hopkins University, Department of Biology, Graduate Biophysical Chemistry 020.674, 15-35 students/yr, 4-6 lectures |
2002 - 2003 Johns Hopkins University, Department of Biophysics, Methods in Molecular Biophysics 250.690, ~18 students/yr, 2 lectures |
2003 University of Maryland, College Park, MD, Department of Physiology, Biophysical Methods, ~20 students, 1 lecture |
2004 Johns Hopkins University, Department of Biology, NMR Data Processing and Analysis 020.684, 15 students, 10 lectures |
2004 Carnegie Institute, Critical Thinking in Biology 020.731 (with Douglas Koshland and Chen-Ming Fan), 18 students, 13 lectures |
2004 Johns Hopkins University, Department of Biology, Functional Interpretation of Biological Structures 020.676, 15 students, 13 lectures |
2005 - 2012 Johns Hopkins University, Department of Chemistry, Chemical Biology 030.619 and 620, 5-25 students/yr, 5-6 lectures |
2005 - 2008 Johns Hopkins University, Department of Biology, Biology in Film 020.125, 125-175 students/yr, 2 film discussions/yr (undergraduate) |
2006 Carnegie Institute, Critical Thinking in Biology 020.731 (with Douglas Koshland), 18 students, 13 lectures |
2009 Carnegie Institute, Critical Thinking in Biology 020.731 (with Douglas Koshland), 18 students, 13 lectures |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Natasha Moussouras, Medical College of Wisconsin, 06/2013 - 07/2013 Medical Scientist Training Program Rotation |
James Miller, Medical College of Wisconsin, 07/2013 - 08/2013 Medical Scientist Training Program Rotation |
Graduate Students |
PhD Students Advised |
Richard Armstrong, Medical College of Wisconsin, 2012 Interdisciplinary Program in Biomedical Sciences |
Rebecca Holme, Medical College of Wisconsin, 2012 Interdisciplinary Program in Biomedical Sciences |
Amber Bakkum, Medical College of Wisconsin, 2012 Interdisciplinary Program in Biomedical Sciences |
Aye-Myat Thinn, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences |
John Egner, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences |
Zachary Gerbec, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences |
Mathew Waas, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences |
PhD Committees |
Luis Paniagua, Biochemistry, Medical College of Wisconsin |
Amanda Nevins, Interdisciplinary Program in Biomedical Sciences, Medical College of Wisconsin |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
Ron James, Baltimore Polytechnical Institute, 09/2004 - 11/2004 Research practicum mentor |
Jack Flowers, The Gilman School, 06/2009 - 08/2009 Research Mentor |
Dylan Cincotta, River Hill High School, 05/2012 - 12/2012 Research Mentor |
Undergraduate Students |
Aloysus Lawong, Cleveland State Univeristy, 2010 Leadership Council |
Zachary Lee, Rockhurst College, 2010 Summer Research Mentor |
Barrett Zimmermann, Mount Holyoke College, 2011 Summer Research Mentor |
Nelson Milbach, St. Norbert College, 2014 |
Doug Bierer, Marquette University, 2014 |
Eddie Chang, Johns Hopkins University, Research Mentor |
Antonio Kibem Kim, Johns Hopkins University |
David Fishman, Johns Hopkins University, Research Mentor |
Jimmy Tooley, Johns Hopkins University, Research Mentor |
Jeffery W. Craig, Johns Hopkins University, Research Mentor |
Jonathan E. Zuckerman, Johns Hopkins University, Research Mentor |
Ann E. Monahan, Johns Hopkins University, Research Mentor |
Melinda Christie, Johns Hopkins University, Research Mentor |
David Park, Johns Hopkins University, Research Mentor |
David Merrick, Johns Hopkins University, Research Mentor |
Sarah C.P. Williams, Johns Hopkins University, Research Mentor |
Kristyn Hayashi, Johns Hopkins University, Research Mentor |
Taylor J. Barfield, Johns Hopkins University, Research Mentor |
Graduate Students |
PhD Students Advised |
John E. Weldon, Johns Hopkins University, 2000 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Julie A. Dohm, Johns Hopkins University, 06/2001 - 06/2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, Structural and Biophysical Characterization of the I. Mitochondrial Fission Protein Fis1 and II. Transcription Factor Sp1 and Its Cognate Binding Site (with Ru-Chih Huang) |
Guru R. Thuduppathy, Johns Hopkins University, 06/2001 - 10/2005 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, Solution to Membrane Conformational Change of Bcl-xl∆TM |
Erik Billings, Johns Hopkins University, 2001 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Kate Briggman, Johns Hopkins University, 2001 Program in Molecular Biophysics |
Brian Cannon, Johns Hopkins University, 2001 Program in Molecular Biophysics |
Erin Fleming, Johns Hopkins University, 2001 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Jason Weil, Johns Hopkins University, 2001 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Frederick J. Tan, Johns Hopkins University, 06/2002 - 10/2007 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, An Evolutionarily Conserved Role for the C. Elegans Bcl-2 Homolog CED-9 at Mitochondrial Membranes (co-mentored with Andrew Z. Fire) |
Toby Soper, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Caline Karam, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Victoria Hargreaves, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Jennifer Barrila, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Devon Sheppard, Johns Hopkins University, 2002 Program in Molecular Biophysics |
Evan Brower, Johns Hopkins University, 2003 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Bill Hawse, Johns Hopkins University, 2003 Program in Molecular Biophysics |
Alexandra Ebie, Johns Hopkins University, 2003 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Lora Picton, Johns Hopkins University, 06/2004 - 07/2010 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, The Dynamic N-Terminal Arm of Fis1 Regulates Mitochondrial Fission |
Casey Hemmis, Johns Hopkins University, 2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Christopher Sung, Johns Hopkins University, 2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Nancy Van Prooyen, Johns Hopkins University, 2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Robert Wells, Johns Hopkins University, 06/2005 - 04/2011 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, The Role of Fis1 in the Recruitment of Mitochondrial Fission Factors and Its Interaction with Membranes |
Megan Cleland, Johns Hopkins University, 2005 NIH-JHU Graduate Partner Program |
Sarah Hirsh, Johns Hopkins University, 2005 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Daniel Chalk, Johns Hopkins University, 2005 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Joshua Friedman, Johns Hopkins University, 2005 Program in Molecular Biophysics |
Jonathan Lees, Johns Hopkins University, 06/2006 - 10/2012 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, The Cytosolic Domain of Fis1 Forms a Kinetically Trapped Dimer that may be Involved in Mitochondrial Fission |
Laura Thompson, Johns Hopkins University, 2006 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Adam Newman, Johns Hopkins University, 2006 Chemical Biology Graduate Training Program |
Anna Vagstad, Johns Hopkins University, 2006 Chemical Biology Graduate Training Program |
Marijke Koppenol, Johns Hopkins University, 06/2007 - 02/2013 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, Investigating the Functional Role of Fis1 Interactions in Membrane Fission |
Matt Preimesberger, Johns Hopkins University, 2007 Program in Molecular Biophysics |
Cara Marie Manlandro, Johns Hopkins University, 2007 Chemical Biology Graduate Training Program |
Amy Guminski, Johns Hopkins University, 2007 Chemical Biology Graduate Training Program |
Ammon Posey, Johns Hopkins University, 06/2008 - 05/2014 Program in Molecular Biophysics, Intrinsic Disorder and Amphitropism in the Mitochondrial Fission Mechanoenzyme Drp1 (co-mentored with Vincent J. Hilser) |
Victoria Slavik, Johns Hopkins University, 2008 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Cherie Garvis, Johns Hopkins University, 2008 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Ryan Vierling, Johns Hopkins University, 2008 Chemical Biology Graduate Training Program |
Kyle Horvath, Johns Hopkins University, 2009 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Anthony Munoz, Johns Hopkins University, 2009 Program in Molecular Biophysics |
Daniel E. Richman, Johns Hopkins University, 06/2010 - 01/2012 Physics Graduate Program (completing his dissertation with Bertrand Garcia-Moreno) |
Lauren Boucher, Johns Hopkins University, 2010 Chemical Biology Graduate Training Program |
Anna McGeachy, Johns Hopkins University, 2010 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
Mary Weston, Johns Hopkins University, 2010 NIH-JHU Graduate Partner Program |
Selena Rice, Johns Hopkins University, 2010 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program |
PhD Committees |
Chun Tang, University of Maryland, Baltimore County, 2003 |
Sylvia Fannuchi, University of Witwatersrand, South Africa, 2006 |
Mod Jarungjit Rujiviphat, University of Toronto, Canada, 2013 |
Austin Elam, PMB, Johns Hopkins University |
Adam Newman, CBI, Johns Hopkins University |
Alexandra Ebie, Johns Hopkins University |
Erik Billings, Johns Hopkins University |
Megan Mayerle, Johns Hopkins University |
Chris Larkin, Johns Hopkins University |
Ralf Carrilo, Johns Hopkins University |
Dan Pierce, Johns Hopkins University |
Megan Cleland, Johns Hopkins University |
Jennifer Barrila, Johns Hopkins University |
Casey Hemmis, Johns Hopkins University |
Micah Webster, Johns Hopkins University |
Adam Ruben, Johns Hopkins University |
Evan Thompson, Johns Hopkins University |
Daniel Chalk, Johns Hopkins University |
Carlos Castañeda, PMB, Johns Hopkins University |
Sarah Williams, Johns Hopkins University |
Steve Tsang, Johns Hopkins University |
Nannan Zhang, Johns Hopkins University |
Evan Brower, Johns Hopkins University |
Erin Fleming, Johns Hopkins University |
Jeffrey Klein, Johns Hopkins University |
Drew Dudgeon, Johns Hopkins University |
Victoria Hargreaves, Johns Hopkins University |
Stephanie Dirla, Johns Hopkins University |
Heather Pressler, Johns Hopkins University |
John E Weldon, Johns Hopkins University |
Usman Bacha, Johns Hopkins University |
Jovita Diaz, Johns Hopkins University |
Julio Castañeda, Johns Hopkins University |
Brian A. Roelofs, Johns Hopkins University |
John Gallagher, PMB, Johns Hopkins University |
Anna Vagstad, CBI, Johns Hopkins University |
Postdoctoral Students |
Nicholas Zagorski, Johns Hopkins University, Research Mentor |
Salva Casares, Johns Hopkins University, Research Mentor |
Faculty |
Dr. Ira J. Ropson, Pennsylvania State University, 09/2004 - 08/2005 Sabbatical |
PROGRAMMATIC DEVELOPMENTS: |
Educational Programs |
Student |
2004 Course Development, Functional Interpretation of Biological Structures 020.676, Johns Hopkins University |
2004 Graduate Program Co-Founder, Chemical Biology Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University |
2004 Course Development, NMR Data Processing & Analysis 020.684, Johns Hopkins University |
Research Programs |
2006 Protein Society Annual Symposia, Organizer and Reviewer, Mock NIH Grant Review Workshop |
2006 Protein Society Annual Symposia, Panel Member, How to Interview Workshop Panel Member, Career Panel Workshop |
2006 Protein Society Annual Symposia, Presenter, Writing Workshop and Scientific Presentation Workshop |
2007 Protein Society Annual Symposia, Panel Member, How to Interview Workshop |
2007 Protein Society Annual Symposia, Organizer and Reviewer, Mock NIH Grant Review Workshop, Organizer, Career Panel Workshop |
2007 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop |
2008 Protein Society Annual Symposia. Organizer, Mock NIH Grant Review Workshop, Organizer, How to Interview Workshop, Organizer, Career Panel Workshop |
2008 Protein Society Annual Symposia, Presenter, Writing Workshop Presenter, Scientific Presentation Workshop |
2009 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop |
2009 Protein Society Annual Symposia, Organizer, Mock NIH Grant Review Workshop, Organizer, Career Panel Workshop |
2009 Protein Society Annual Symposia, Panel Member, How to Interview Workshop |
2010 Protein Society Annual Symposia, Organizer, Mock NIH Grant Review Workshop, Organizer, How to Interview Workshop, Organizer, Career Panel Workshop |
2010 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop |
2011 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop |
2011 Protein Society Annual Symposia, Organizer, Mock NIH Grant Review Workshop, Organizer, How to Interview Workshop, Organizer, Career Panel Workshop |
COMMUNITY SERVICE ACTIVITIES: |
2005 - 2010 Advisor on college admissions to high school students |
2006 - 2008 Volunteer, Facility Committee, Baltimore Montessori Public Charter School |
2008 - 2011 Volunteer, IT Committee, Baltimore Montessori Public Charter School |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. R.W. Kriwacki, R.B. Hill, J.M. Flanagan, J.P. Caradonna, and J.H. Prestegard, "New NMR methods for the characterization of bound waters in macromolecules", J Am Chem Soc 115, 8907-8911 (1993). |
2. B.D. Albertson, R.B. Hill, K.A. Sprague, K.E. Wood, L.K. Nieman, and D.L. Loriaux, "The effect of the antiglucocorticoid RU486 on adrenal steroidogenic enzyme activity and steroidogenesis", Eur J Endocrinol 130, 195-200 (1994). |
3. M. Andrec, R.B. Hill, and J.H. Prestegard, "Amide exchange rates in Escherichia coli Acyl Carrier Protein: correlation with protein structure and dynamics", Protein Sci 4, 983-993 (1995). |
4. R.B. Hill, J.M. Flanagan, and J.H. Prestegard, "1H and 15N Magnetic resonance assignments, secondary structure, and tertiary fold of E. coli DnaJ(1-78)", Biochemistry 34, 5587-5595 (1995). |
5. R.B. Hill, K.R. MacKenzie, J.M. Flanagan, and J.H. Prestegard, "Overexpression, purification, and characterization of E. coli Acyl Carrier Protein and two mutant proteins", Protein Exp and Purif 66, 394-400 (1995). |
6. R.B. Hill and W.F. DeGrado, "Solution structure of α2D, a nativelike de novo designed protein", J Am Chem Soc 120, 1138-1145 (1998). |
7. R.B. Hill, J-K Hong, and W.F. DeGrado, "A hydrogen bonding cluster can specify the unique conformation of a protein", J Am Chem Soc 122, 746-747 (2000). |
8. R.B. Hill and W.F. DeGrado, "A polar, solvent-exposed residue can be essential for native protein structure", Structure 8, 471-479 (2000). |
9. R.B. Hill, C. Bracken, W.F. DeGrado, and A.G. Palmer, "Molecular motions and protein folding: Characterization of the backbone dynamics and folding equilibrium of α2D by 13C NMR spin relaxation methods", J Am Chem Soc 122, 11610-11619 (2000). |
10. D.A. Salom, R.B. Hill, J.D. Lear, and W.F. DeGrado, "pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus", Biochemistry 39, 14160-14170 (2000). |
11. M.G. VanderHeiden, X.X. Li, E. Gottlieb, R.B. Hill, C.B. Thompson, and M. Colombini, "Bcl-xL promotes both the open configuration of the VDAC and metabolite passage through the |
12. outer mitochondrial membrane", J Biol Chem 276, 19414-19419 (2001). |
13. J.A. Dohm, S.J. Lee, J.M. Hardwick, R.B. Hill*, and A.G. Gittis*, "The cytosolic domain of the human mitochondrial fission protein Fis1 adopts a TPR fold", Proteins 54,153-6 (2004). |
14. Y. Fannjiang, W.C. Cheng, S.J. Lee, B. Qi, J. Pevsner, J.M. McCaffery, R.B. Hill, G. Basañez, and J.M. Hardwick, "Mitochondrial fission proteins regulate programmed cell death in yeast.", Genes Dev 18, 2785-97 (2004). |
15. G.R. Thuduppathy and R.B. Hill, "Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes", Protein Sci 15, 248-57 (2006). |
16. G.R. Thuduppathy, J. W. Craig, V. Kholodenko, A. Schon, and R.B. Hill, "Evidence that membrane insertion of the cytosolic domain of Bcl-xL might be governed by an electrostatic mechanism", J Mol Biol 359,1045-58 (2006). |
17. G.R. Thuduppathy, O. Terrones, J. W. Craig, G. Basañez, and R.B. Hill, "The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner", Biochemistry 45,14533-42 (2006). |
18. F.J. Tan, J.E. Zuckerman, A.Z. Fire, and R.B. Hill, "Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain", Cell Death Differ 14,1925-35 (2007). |
19. R.C. Wells, L.K. Picton, S.C.P. Williams, F.J. Tan, and R.B. Hill, "Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm.", J Biol Chem 282, 33769-75 (2007). |
20. L.J. Siskind, L. Feinstein, T. Yu, J.S. Davis, D. Jones, J. Choi, J.E. Zuckerman, W. Tan, R. B. Hill, J.M. Hardwick, and M. Colombini "Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels", J Biol Chem 283, 6622-6630 (2008). |
21. D.A. De Cotiis, M.P. Woll, T.E. Fox, R.B. Hill, R. Levenson, J.M. Flanagan, "Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli." Protein Expr Purif 61, 103-12 (2008). |
22. F.J. Tan, M. Husain, C.M. Manlandro, M. Koppenol, A.Z. Fire, & R.B. Hill, "CED-9 and mitochondrial homeostasis in C. elegans muscle. J Cell Sci 102, 3373-82 (2008). |
23. M.M. Parrott, S.A. Sitarski, R.J. Arnold, L.K. Picton, R.B. Hill, and S. Mukhopadhyay. "Role of conserved cysteines in the alphavirus E3 protein. J Virol 83, 2584-91 (2009). |
24. L.K. Picton, S. Casares, A.C. Monahan, A. Majumdar, & R.B. Hill, "Evidence for conformational heterogeneity of fission protein Fis1 from S. cerevisiae", Biochemistry 48, 6598-609 (2009). |
25. C.R. Chang†, C.M. Manlandro†, D. Arnoult, J. Stadler, A.E. Posey, R.B. Hill*, and C. Blackstone*, "A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher-order assembly and mitochondrial division", J Biol Chem 285, 32494-503 (2010). |
26. F.J. Tan, J.E. Zuckerman, R.C. Wells, R.B. Hill, "The C. elegans B-cell lymphoma 2 (bcl-2) homolog Cell death abnormal 9 (CED-9) associates with and remodels lipid membranes", Protein Sci 20, 62-74 (2011). |
27. D.V. Jeyaraju, H.M. McBride, R.B. Hill*, L. Pellegrini*, "Structural and mechanistic basis of Parl activity and regulation", Cell Death Differ 18, 1531-9 (2011). |
28. R.C. Wells and R.B. Hill, "The Fis1 cytosolic domain binds and reversibly clusters lipid vesicles", PLoS-1, 6, e21384 (2011). doi:10.1371/journal.pone.0021384 |
29. J.E. Tooley, V. Khangulov, J.P. Lees, J.L. Schlessman, M.C. Bewley, A. Héroux, J. Bosch*, |
30. |
31. J.P. Lees, C.M. Manlandro, L.K. Picton, A.Z.E. Tan, S. Casares, J.M. Flanagan, K.G. |
32. Fleming, and R.B. Hill, "A designed point mutant in Fis1 disrupts dimerization and |
33. mitochondrial fission", J Mol Biol, 423,143-58 (2012). doi: 10.1016/j.jmb.2012.06.042 |
34. A.R. Diers, K.A. Broniowska, C.F. Chang, R.B. Hill, N. Hogg, "S-Nitrosation of monocarboxylate transporter 1: Inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells", Free Rad Biol Med 69:229-38 (2014). |
35. †co-first authors *co-corresponding authors |
Books, Chapters, and Reviews |
1. E.T. Lally, R.B. Hill, I.R. Kieba, and J. Korostoff, "The interaction between RTX Toxins and target cells", Trends Microbiol 7, 356-361 (1999). |
2. R.B. Hill, D.P. Raleigh, A. Lombardi, and W.F. DeGrado, "De novo design of helical bundles as models for understanding protein folding and function", Acc Chem Res 33, 745-754 (2000). |
3. G.R. Thuduppathy and R.B. Hill, "Applications of NMR Spin Relaxation Methods for Measuring Biological Motions", Methods Enzymol 384, 243-64 (2004). |
4. Hill R.B., Pellegrini L. "The PARL family of mitochondrial rhomboid proteases." |
