Medical College of Wisconsin
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CURRICULUM VITAE

Ronald Blake Hill PhD
Professor
Department of Biochemistry

OFFICE ADDRESS:
Translational and Biomedical Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
09/1980 - 06/1984 B.A., Kalamazoo College, Kalamazoo, MI
09/1987 - 04/1995 Ph.D., Yale University, New Haven, CT

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
05/1995 - 06/2000 Postdoctoral Fellow, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylanvia, 3700 Hamilton Walk, Philadelphia, PA 19104-6059

FACULTY APPOINTMENTS:
07/2000 - 07/2006 Assistant Professor, Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
07/2006 - 07/2012 Associate Professor, Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
08/2012 - Present Professor, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
09/2000 - 07/2012 Preceptor, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Molecular Biophysics Graduate Training Program, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
09/2000 - 07/2012 Preceptor, Zanvyl Krieger School of Arts & Sciences, Molecular, Developmental Biology and Biophysics Graduate Training Program, Johns Hopkins University, 3520 San Martin Drive, Carnegie Institution for Science, Department of Embryology, Baltimore, MD 21218
01/2004 - 09/2005 Co-Founder, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Chemical Biology Graduate Training Program, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
09/2005 - 07/2012 Preceptor, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Chemical Biology Graduate Training Program, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
09/2005 - 07/2012 Member, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Institute for NanoBioTechnology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
09/2012 - Present Preceptor, Medical Scientist Training Program, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226
09/2012 - Present Preceptor, Interdisciplinary Program in Biomedical Sciences, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226

RESEARCH ADMINISTRATIVE APPOINTMENTS:
01/2001 - 03/2012 Lead Scientist, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Design of Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
01/2002 - 12/2002 Lead Scientist, Zanvyl Krieger School of Arts & Sciences, Design and Construction of Temporary NMR Space, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
01/2002 - 09/2004 Lead Scientist, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Construction of Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
01/2004 - 07/2012 Co-Director, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
12/2004 - 06/2006 Lead Negotiator, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Failed 800 MHz NMR Instruments Biomedical Nuclear Magnetic Resonance Center, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218
12/2010 - 07/2012 Member, Zanvyl Krieger School of Arts & Sciences, Research Infrastructure Committee, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218

AWARDS AND HONORS:
09/1980 - 06/1984 Honors Scholarship, Kalamazoo College
09/1987 - 06/1992 Frederick S. Heyl Doctoral Fellowship, Yale University
09/1989 - 05/1995 Graduate Fellow, Calhoun College, Yale University
09/1996 - 08/1998 NIH - NRSA Postdoctoral Fellowship
09/1998 - 06/2000 George W. Raiziss Postdoctoral Fellow, University of Pennsylvania
09/2007 - 05/2007 Excellence in Teaching Award Nominee, Johns Hopkins

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
American Association for the Advancement of Science
American Chemical Society
Protein Society
Biophysical Society
American Society for Biochemistry and Molecular Biology

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
BBA-Membranes
Biochemistry
Cell Death and Differentiation
Chemical Reviews
European Journal of Biophysics
FEBS Letters Journal of American Chemical Society
Journal of Biological Chemistry
Journal of Cellular Biochemistry,
Journal of Cellular and Molecular Medicine
Journal of Cell Science
Journal of Molecular Biology
PLOS One
Protein Engineering Design and Selection
Protein Science
Proteins
PNAS
Protein & Peptide Letters
Nature Structural & Molecular Biology
Analytical Biochemistry
Biophysical Journal

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2002 - Present Member, Mentoring Committee, Protein Society
2003 - 2005 Ad Hoc Reviewer, International Science & Technology Center
06/2004 Ad Hoc Reviewer, Special Emphasis Study Section ZRG1, National Institutes of Health
07/2004 Panel Member, University Education, Protein Society Annual Symposium
06/2006 Ad Hoc Reviewer, Study Section, S10 SIG, National Institutes of Health
2006 - 2011 Chair, Mentoring Committee, Protein Society
2007 - 2010 Ad Hoc Reviewer, individual investigator/CAREER awards, National Science Foundation
02/2008 Ad Hoc Reviewer, Study Section, Molecular Structure and Function B, National Institutes of Health
2008 - 2011 Member, Membership Committee, Protein Society
02/2009 Ad Hoc Reviewer, Study Section, S10 SIG, National Institutes of Health
2009 Ad Hoc Reviewer, ARRA awards, National Institutes of Health
2010 Ad Hoc Reviewer, National Research Foundation, Thuthuka Program, South Africa
06/2011 Ad Hoc Reviewer, Study Section, S10 SIG (declined), National Institutes of Health
2011 Ad Hoc Reviewer, Director’s Early Independence Award (DP5), National Institutes of Health
2011 Ad Hoc Reviewer, National Research Foundation, South Africa
2012 Ad Hoc Reviewer, Medical Research Council, United Kingdom
2012 Ad Hoc Reviewer, Bioinformatics and Genetics Pilot Project Program, South Carolina INBRE
10/2013 Ad Hoc Reviewer, Study Section, Biochemistry and Biophysics of Membranes, National Institutes of Health
2013 - Present Member, Publications Committee, American Society for Biochemistry and Molecular Biology
02/2014 Ad Hoc Reviewer, Study Section, Biochemistry and Biophysics of Membranes, National Institutes of Health

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Fis1 Regulation of Mitochondrial Fission
Source:
NIH
Role:
Principal Investigator
Dates:
04/01/2004 - 03/31/2015
Direct Funds:
$2,100,000 (projected total for all years)
  
Pending
Peer Review
Title:
Fis1 Regulation of Mitochondrial Fission
Source:
NIH
Role:
Principal Investigator
Dates:
04/01/2015 - 03/31/2020
Direct Funds:
$1,250,000 (total for all years)
  
Prior
Peer Review
Title:
Design and Structure of de novo designed helical proteins
Source:
NIH
Role:
Principal Investigator
Dates:
09/1996 - 08/1998
  
Title:
Acquisition of a 750 MHz NMR Spectrometer/Cryoprobe
Source:
NSF Major Research Instrumentation Grant
Role:
Co-Principal Investigator
Dates:
04/2002 - 03/31/2003
Direct Funds:
$1,180,000
  
Title:
400 MHz NMR Spectrometer for Shared Use
Source:
NIH
Role:
Contributor
Dates:
04/2004 - 03/31/2005
Direct Funds:
$360,000
  
Title:
Peptide Synthesis System to Probe Protein Structure and
Source:
NSF Chemical Instrumentation Grant
Role:
Contributor
Dates:
04/2005 - 03/31/2006
Direct Funds:
$86,000
  
Title:
600 MHz NMR Spectrometer for Shared Use
Source:
NIH
Role:
Principal Investigator
Dates:
04/2005 - 03/31/2006
Direct Funds:
$500,000
  
Title:
Purchase of a Research Grade MALDI-ToF
Source:
NSF Chemical Instrumentation Grant
Role:
Contributor
Dates:
04/2009 - 03/31/2010
Direct Funds:
$260,000
  
Title:
Multiangle Laser Light Scattering and Refractive Index
Source:
NIH
Role:
Principal Investigator
Dates:
04/2009 - 08/31/2009
Direct Funds:
$64,000
  
Title:
Purchase of a 600 MHz NMR Console and Probes
Source:
NIH
Role:
Major User
Dates:
03/15/2011 - 03/31/2012
Direct Funds:
$550,000
  
Title:
Research Supplements to Promote Diversity in
Source:
NIH
Role:
Principal Investigator
Dates:
03/15/2011 - 05/31/2013
Direct Funds:
$30,000
  
Non-Peer Review
Title:
Uncovering the Molecular Details of Inhibiting Bcl-xL
Source:
American Cancer Society Institutional Research Grant
Role:
Principal Investigator
Dates:
04/2002 - 03/31/2003
Direct Funds:
$20,000
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Invited Speaker, Johns Hopkins School of Medicine, Department of Biological Chemistry, Baltimore, MD, 2001
Invited Speaker, Johns Hopkins Bloomberg School of Public Health, Department of Molecular Biology & Biochemistry, Baltimore, MD, 2004
Invited Speaker, Milwaukee Area Structural Biology Interest Group, Milwaukee, WI, 2013
 
National
Endocrine Society 68th Annual Meeting, Anaheim, CA, 1986
Frontiers of NMR in Molecular Biology III, Keystone Symposium, Taos, NM, 1993
Invited Speaker, Proctor & Gamble, Cincinnati, OH, 1994
35th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 1994
Invited Speaker, Genetics Institute, Cambridge, MA, 1994
37th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 1996
18th International Conference on Magnetic Resonance in Biological Systems, Keystone, CO, 1996
Invited Speaker, University of Utah, Department of Chemistry, Salt Lake City, UT, 1999
Invited Speaker, Kalamazoo College, Department of Chemistry, Kalamazoo, MI, 1999
Invited Speaker, Center for Advanced Research in Biotechnology, Rockville, MD, 1999
Invited Speaker, Bioorganic Chemistry Gordon Conference, Proctor Academy, Andover, NH, 1999
Invited Speaker, Dartmouth College, Department of Chemistry, Hanover, NH, 1999
Invited Speaker, University of Maryland, Department of Chemistry and Biochemistry, College Park, MD, 1999
Invited Speaker, Johns Hopkins University, Department of Biology, Baltimore, MD, 2000
41st Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 2000
Invited Speaker, niversity of Illinois at Chicago, Department of Chemistry, Chicago, IL, 2000
Invited Speaker, Albert Einstein College of Medicine, Department of Biophysics, Bronx, NY, 2000
14th Gibbs Conference in Biological Thermodynamics, Carbondale, IL, 2000
6th Johns Hopkins Folding Meeting, Berkeley Springs, WV, 2001
Cold Spring Harbor Meeting on Cell Death, Cold Spring Harbor Lab, NY, 2001
7th Johns Hopkins Folding Meeting, Berkeley Springs, WV, 2003
Invited Speaker, Columbia University School of Medicine, Biophysics and Biochemistry, New York, NY, 2003
Invited Speaker, Kalamazoo College, Department of Chemistry, Kalamazoo, MI, 2004
Mitochondria and Chloroplasts Gordon Conference, Kimball Union Academy, Meriden, NH, 2004
45th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, 2004
48th Annual Meeting, Biophysical Society, Baltimore, MD, 2004
Invited Speaker, City College of New York, Department of Chemistry and Biochemistry, New York, NY, 2005
Invited Speaker, NMR Recent Developments in Magnetic Resonance: Liquid and Solid State Applications, Theoretical Methodology, and Emerging Techniques, Division of Physical Chemistry, 229th American Chemical Society National Meeting, San Diego, CA, 2005
20th Annual Symposium, Protein Society, San Diego, CA, 2006
Frontiers in Structural Biology, Keystone Symposium, Keystone, CO, 2006
Invited Speaker, University of Maryland, Biophysics Program, College Park, MD, 2006
Invited Speaker, Cell Death Gordon Research Conference, Big Sky, MT, 2006
Invited Speaker, Emory University, Department of Chemistry, Atlanta, GA, 2006
Interactions of Peptides and Proteins with Membrane Surfaces, 231st American Chemical Society National Meeting, Division of Physical Chemistry, Atlanta, GA, 2006
Invited Speaker, Summit on Facilities for Emerging Sciences, St. Petersburg, FL, 2006
Invited Speaker, Biennial Biomolecular NMR Symposium, Center for Advanced Research in Biotechnology, Rockville, MD, 2006
Invited Speaker, University of Massachusetts Medical School, Department of Biochemistry & Molecular Pharmacology, Worcester, MA, 2006
Invited Speaker, Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, MD, 2006
Salon des Refusés Platform Session on Bcl-2 Proteins (with Dr. Marco Colombini), Biophysical Society Annual Meeting, Baltimore, MD, 2007
21st Annual Symposium, Protein Society, Boston, MA, 2007
Assembly of the Mitochondrial Respiratory Chain, FASEB Summer Research Conference, Tucson, AZ, 2007
Invited Speaker, University of Indiana, Department of Chemistry & Biochemistry, Bloomington, IN, 2007
Invited Speaker, Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 2008
Invited Speaker, Structure, Property, and Function of Cell Membranes and Membrane Related Biomolecule, 235th American Chemical Society National Meeting, Division of Colloid & Surface Chemistry, New Orleans, LA, 2008
22nd Annual Symposium, Protein Society, San Diego, CA, 2008
Mitochondrial Physiology and Pathobiology, Charleston, SC, 2009
Invited Speaker, St. Jude Children's Research Hospital, Memphis, TN, 2009
Session Chair, 23rd Annual Symposium, Protein Society, Boston, MA, 2009
50th Annual Meeting, American Society for Cell Biology, Philadelphia, PA, 2010
Invited Speaker, University of California Skaggs School of Pharmacy, San Diego, CA, 2010
Invited Speaker, University of California, Department of Chemistry & Biochemistry, Santa Barbara, CA, 2010
Invited Speaker, Burnham Institute, San Diego, CA, 2010
24th Annual Symposium, Protein Society, San Diego, CA, 2010
Invited Speaker, Cornell University Weil School of Medicine, Department of Biochemistry, New York, NY, 2010
Invited Speaker, University of California, Department of Chemistry and Biochemistry, Irvine, CA, 2010
Invited Speaker, University of California, Department of Chemistry, San Diego, CA, 2010
Molecular Basis for Biological Membrane Organization and Dynamics, Keystone Symposium, Snowbird, UT, 2010
55th Annual Meeting, Biophysical Society, Baltimore, MD, 2011
Invited Speaker, Mitochondrial Assembly & Dynamics in Health, Disease & Aging, FASEB Summer Research Conference, Steamboat, CO, 2011
Invited Speaker, 25th Annual Symposium, Protein Society, Boston, MA, 2011
Invited Speaker, Proteins Gordon Research Conference, Holderness School, Holderness, NH, 2011
Invited Speaker, University of Maryland School of Medicine, Department of Biochemistry, Baltimore, MD, 2011
Invited Speaker, Texas A&M University, Department of Biochemistry, College Station, TX, 2012
Invited Speaker, University of Illinois School of Medicine, Department of Physiology, Chicago, IL, 2012
Invited Speaker, Institute for Marine and Environmental Technology, University of Maryland, Baltimore, MD, 2012
Invited Speaker, University of Maryland Baltimore County, Department of Biology, Catonsville, MD, 2012
Invited Speaker, Boston Biomedical Research Institute, Boston, MA, 2012
Invited Speaker, University of Colorado Health Sciences, Department of Biochemistry, Aurora, CO, 2012
Co-Chair, Protein Conformation Platform Session, 56th Annual Meeting, Biophysical Society, San Diego, CA, 2012
Invited Speaker, University of Houston, Department of Biology and Biochemistry, Houston, TX, 2012
Invited Speaker, University of Maryland School of Medicine, Department of Biochemistry, Baltimore, MD, 2012
Invited Speaker, Boston University Medical Center, Department of Biophysics and Physiology, Boston, MA, 2012
Invited Speaker, University of Pittsburgh School of Medicine, Department of Structural Biology, Pittsburgh, PA, 2012
Invited Speaker, Biomolecular Interactions and Methods Gordon Research Conference, Galveston,TX, 2012
Invited Speaker, University of Medicine and Dentistry of New Jersey, Department of Cell Biology, Piscataway, NJ, 2012
Invited Speaker, Biomolecular Structure, Dynamics, and Function: Membrane Proteins, Vanderbilt University, Nashville, TN, 2014
Invited Speaker, Emerging Roles of Mitochondria in Cell Signaling, Physiology and Disease, ASBMB Annual Meeting, San Diego, CA, 2014
Biomolecular Structure, Dynamics, and Function 1 (with Drs. Kevin Gardner and Richard Kriwacki), Memphis, TN
 
International
Mitochondria and Chloroplasts Gordon Conference, Oxford University, Oxford, England, 2006
Invited Speaker, 7th European School of Haematolog International Euroconference on Mechanisms of Cell Death & Disease: Advances in Therapeutic Intervention and Drug Development, Cascais, Portugal, 2008
Session Chair, Mitochondrial Dynamics: from Mechanism to Disease, Sardinia, Italy, 2011
CNRS, Centre de Biochimie Structurale, Montpellier, France, 2011
The Institute of Cancer Research, Division of Structural Biology, London, England, 2011
Invited Speaker, 5th International Congress on Stress Responses in Biology and Medicine, Quebec City, Quebec, Canada, 2011
 

COMMITTEE SERVICE:
Medical College of Wisconsin
2001 - 2002 Member, Faculty Search Committee, Department of Chemistry, Johns Hopkins University
2001 - 2002 Member, Howard Hughes Medical Institute Summer Undergraduate Research Fellowship Selection Committee, Johns Hopkins University
2001 - 2003 Member, Seminar Committee, Department of Biology, Johns Hopkins University
2001 - 2002 Member, Howard Hughes Medical Institute Summer Undergraduate Research Fellowship Selection Committee, Johns Hopkins University
2001 - 2005 Zanvyl Krieger School of Arts and Sciences Representative, Graduate Board, Johns Hopkins University
2002 - 2006 Meyerhoff Mentor, Meyerhoff Scholar Program, University of Maryland Baltimore County
2002 - 2003 Principle Investigator, Acquisition and Installation of two 600 MHz NMR instruments, Johns Hopkins University
2002 - 2004 Member, Retreat Organizing Committee, Cellular, Molecular, Developmental Biology, and Biophysics Graduate Training Program, Johns Hopkins University
2003 Poster Judge, 6th Annual Symposium Undergraduate Research Symposium
2003 Member, Facility Manager Search Committee, Biomedical NMR Center, Johns Hopkins University
2004 - 2007 Chair, Seminar Committee, Department of Biology, Johns Hopkins University
2005 - 2011 Member, Health Professions Committee, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
2005 - 2008 Member, Retreat Organizing Committee, Cellular, Molecular, Developmental Biology, and Biophysics Graduate Training Program, Johns Hopkins University
2005 - 2008 Member, Steering Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
2005 - 2008 Member, Curriculum Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
2005 - 2011 Member, Advising Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
2005 - 2008 Member, Admissions Committee, Chemical Biology Interface Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
2006 Mentor, Research Practicum, Baltimore Polytechnic Institute
2008 Member, Director Search Committee, Postbaccalaureate Medical Education Program, Johns Hopkins University
2008 - 2010 Member, Curriculum Committee, Department of Biology, Johns Hopkins University
2008 - 2009 Member, Faculty Search Committee, Department of Biology, Johns Hopkins University
2009 - 2010 Member, Faculty Search Committee, Department of Biology, Johns Hopkins University
2010 - 2011 Member, Summer Undergraduate Fellowship Selection Committee, Institute for NanoBioTechnology, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
2012 - Present Case-Based Discussions, Molecules To Cells, M1 Core Course , ~20 students, 3 cases
2013 - Present Molecules To Cells, M1 Core Course, ~210 students, 3 lectures
 

EXTRAMURAL TEACHING:
Continuing Medical Education
2008 Johns Hopkins University, Biological Impacts of Climate Change, "Alumni College", ~50 alumni, 1 lecture
 
Graduate Student Education
2001 - 2012 Johns Hopkins University, Department of Biology, Research Problems in Biology 020.513, 1-5 students/yr (undergraduate)
2001 - 2010 Johns Hopkins University, Department of Biology, Biochemistry 020.305, 400-475 students/yr, 18-26 lectures/yr (undergraduate)
2002 Johns Hopkins University, Department of Biophysics, Introduction to Biomedical Research & Careers 025.106 21 students, 1 lecture and dinner (undergraduate)
2002 United States Naval Academy, Annapolis, MD, Department of Chemistry & Biochemistry, Biochemistry, ~20 cadets, 1 lecture (undergraduate)
2002 - 2012 Johns Hopkins University, Department of Biology, Graduate Biophysical Chemistry 020.674, 15-35 students/yr, 4-6 lectures
2002 - 2003 Johns Hopkins University, Department of Biophysics, Methods in Molecular Biophysics 250.690, ~18 students/yr, 2 lectures
2003 University of Maryland, College Park, MD, Department of Physiology, Biophysical Methods, ~20 students, 1 lecture
2004 Johns Hopkins University, Department of Biology, NMR Data Processing and Analysis 020.684, 15 students, 10 lectures
2004 Carnegie Institute, Critical Thinking in Biology 020.731 (with Douglas Koshland and Chen-Ming Fan), 18 students, 13 lectures
2004 Johns Hopkins University, Department of Biology, Functional Interpretation of Biological Structures 020.676, 15 students, 13 lectures
2005 - 2012 Johns Hopkins University, Department of Chemistry, Chemical Biology 030.619 and 620, 5-25 students/yr, 5-6 lectures
2005 - 2008 Johns Hopkins University, Department of Biology, Biology in Film 020.125, 125-175 students/yr, 2 film discussions/yr (undergraduate)
2006 Carnegie Institute, Critical Thinking in Biology 020.731 (with Douglas Koshland), 18 students, 13 lectures
2009 Carnegie Institute, Critical Thinking in Biology 020.731 (with Douglas Koshland), 18 students, 13 lectures
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Natasha Moussouras, Medical College of Wisconsin, 06/2013 - 07/2013 Medical Scientist Training Program Rotation
James Miller, Medical College of Wisconsin, 07/2013 - 08/2013 Medical Scientist Training Program Rotation
 
Graduate Students
PhD Students Advised
Richard Armstrong, Medical College of Wisconsin, 2012 Interdisciplinary Program in Biomedical Sciences
Rebecca Holme, Medical College of Wisconsin, 2012 Interdisciplinary Program in Biomedical Sciences
Amber Bakkum, Medical College of Wisconsin, 2012 Interdisciplinary Program in Biomedical Sciences
Aye-Myat Thinn, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences
John Egner, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences
Zachary Gerbec, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences
Mathew Waas, Medical College of Wisconsin, 2013 Interdisciplinary Program in Biomedical Sciences
PhD Committees
Luis Paniagua, Biochemistry, Medical College of Wisconsin
Amanda Nevins, Interdisciplinary Program in Biomedical Sciences, Medical College of Wisconsin
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
High School Students
Ron James, Baltimore Polytechnical Institute, 09/2004 - 11/2004 Research practicum mentor
Jack Flowers, The Gilman School, 06/2009 - 08/2009 Research Mentor
Dylan Cincotta, River Hill High School, 05/2012 - 12/2012 Research Mentor
 
Undergraduate Students
Aloysus Lawong, Cleveland State Univeristy, 2010 Leadership Council
Zachary Lee, Rockhurst College, 2010 Summer Research Mentor
Barrett Zimmermann, Mount Holyoke College, 2011 Summer Research Mentor
Nelson Milbach, St. Norbert College, 2014
Doug Bierer, Marquette University, 2014
Eddie Chang, Johns Hopkins University, Research Mentor
Antonio Kibem Kim, Johns Hopkins University
David Fishman, Johns Hopkins University, Research Mentor
Jimmy Tooley, Johns Hopkins University, Research Mentor
Jeffery W. Craig, Johns Hopkins University, Research Mentor
Jonathan E. Zuckerman, Johns Hopkins University, Research Mentor
Ann E. Monahan, Johns Hopkins University, Research Mentor
Melinda Christie, Johns Hopkins University, Research Mentor
David Park, Johns Hopkins University, Research Mentor
David Merrick, Johns Hopkins University, Research Mentor
Sarah C.P. Williams, Johns Hopkins University, Research Mentor
Kristyn Hayashi, Johns Hopkins University, Research Mentor
Taylor J. Barfield, Johns Hopkins University, Research Mentor
 
Graduate Students
PhD Students Advised
John E. Weldon, Johns Hopkins University, 2000 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Julie A. Dohm, Johns Hopkins University, 06/2001 - 06/2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, Structural and Biophysical Characterization of the I. Mitochondrial Fission Protein Fis1 and II. Transcription Factor Sp1 and Its Cognate Binding Site (with Ru-Chih Huang)
Guru R. Thuduppathy, Johns Hopkins University, 06/2001 - 10/2005 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, Solution to Membrane Conformational Change of Bcl-xl∆TM
Erik Billings, Johns Hopkins University, 2001 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Kate Briggman, Johns Hopkins University, 2001 Program in Molecular Biophysics
Brian Cannon, Johns Hopkins University, 2001 Program in Molecular Biophysics
Erin Fleming, Johns Hopkins University, 2001 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Jason Weil, Johns Hopkins University, 2001 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Frederick J. Tan, Johns Hopkins University, 06/2002 - 10/2007 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, An Evolutionarily Conserved Role for the C. Elegans Bcl-2 Homolog CED-9 at Mitochondrial Membranes (co-mentored with Andrew Z. Fire)
Toby Soper, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Caline Karam, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Victoria Hargreaves, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Jennifer Barrila, Johns Hopkins University, 2002 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Devon Sheppard, Johns Hopkins University, 2002 Program in Molecular Biophysics
Evan Brower, Johns Hopkins University, 2003 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Bill Hawse, Johns Hopkins University, 2003 Program in Molecular Biophysics
Alexandra Ebie, Johns Hopkins University, 2003 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Lora Picton, Johns Hopkins University, 06/2004 - 07/2010 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, The Dynamic N-Terminal Arm of Fis1 Regulates Mitochondrial Fission
Casey Hemmis, Johns Hopkins University, 2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Christopher Sung, Johns Hopkins University, 2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Nancy Van Prooyen, Johns Hopkins University, 2004 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Robert Wells, Johns Hopkins University, 06/2005 - 04/2011 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, The Role of Fis1 in the Recruitment of Mitochondrial Fission Factors and Its Interaction with Membranes
Megan Cleland, Johns Hopkins University, 2005 NIH-JHU Graduate Partner Program
Sarah Hirsh, Johns Hopkins University, 2005 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Daniel Chalk, Johns Hopkins University, 2005 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Joshua Friedman, Johns Hopkins University, 2005 Program in Molecular Biophysics
Jonathan Lees, Johns Hopkins University, 06/2006 - 10/2012 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, The Cytosolic Domain of Fis1 Forms a Kinetically Trapped Dimer that may be Involved in Mitochondrial Fission
Laura Thompson, Johns Hopkins University, 2006 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Adam Newman, Johns Hopkins University, 2006 Chemical Biology Graduate Training Program
Anna Vagstad, Johns Hopkins University, 2006 Chemical Biology Graduate Training Program
Marijke Koppenol, Johns Hopkins University, 06/2007 - 02/2013 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program, Investigating the Functional Role of Fis1 Interactions in Membrane Fission
Matt Preimesberger, Johns Hopkins University, 2007 Program in Molecular Biophysics
Cara Marie Manlandro, Johns Hopkins University, 2007 Chemical Biology Graduate Training Program
Amy Guminski, Johns Hopkins University, 2007 Chemical Biology Graduate Training Program
Ammon Posey, Johns Hopkins University, 06/2008 - 05/2014 Program in Molecular Biophysics, Intrinsic Disorder and Amphitropism in the Mitochondrial Fission Mechanoenzyme Drp1 (co-mentored with Vincent J. Hilser)
Victoria Slavik, Johns Hopkins University, 2008 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Cherie Garvis, Johns Hopkins University, 2008 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Ryan Vierling, Johns Hopkins University, 2008 Chemical Biology Graduate Training Program
Kyle Horvath, Johns Hopkins University, 2009 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Anthony Munoz, Johns Hopkins University, 2009 Program in Molecular Biophysics
Daniel E. Richman, Johns Hopkins University, 06/2010 - 01/2012 Physics Graduate Program (completing his dissertation with Bertrand Garcia-Moreno)
Lauren Boucher, Johns Hopkins University, 2010 Chemical Biology Graduate Training Program
Anna McGeachy, Johns Hopkins University, 2010 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
Mary Weston, Johns Hopkins University, 2010 NIH-JHU Graduate Partner Program
Selena Rice, Johns Hopkins University, 2010 Cellular, Molecular, & Developmental Biology and Biophysics Graduate Training Program
PhD Committees
Chun Tang, University of Maryland, Baltimore County, 2003
Sylvia Fannuchi, University of Witwatersrand, South Africa, 2006
Mod Jarungjit Rujiviphat, University of Toronto, Canada, 2013
Austin Elam, PMB, Johns Hopkins University
Adam Newman, CBI, Johns Hopkins University
Alexandra Ebie, Johns Hopkins University
Erik Billings, Johns Hopkins University
Megan Mayerle, Johns Hopkins University
Chris Larkin, Johns Hopkins University
Ralf Carrilo, Johns Hopkins University
Dan Pierce, Johns Hopkins University
Megan Cleland, Johns Hopkins University
Jennifer Barrila, Johns Hopkins University
Casey Hemmis, Johns Hopkins University
Micah Webster, Johns Hopkins University
Adam Ruben, Johns Hopkins University
Evan Thompson, Johns Hopkins University
Daniel Chalk, Johns Hopkins University
Carlos Castañeda, PMB, Johns Hopkins University
Sarah Williams, Johns Hopkins University
Steve Tsang, Johns Hopkins University
Nannan Zhang, Johns Hopkins University
Evan Brower, Johns Hopkins University
Erin Fleming, Johns Hopkins University
Jeffrey Klein, Johns Hopkins University
Drew Dudgeon, Johns Hopkins University
Victoria Hargreaves, Johns Hopkins University
Stephanie Dirla, Johns Hopkins University
Heather Pressler, Johns Hopkins University
John E Weldon, Johns Hopkins University
Usman Bacha, Johns Hopkins University
Jovita Diaz, Johns Hopkins University
Julio Castañeda, Johns Hopkins University
Brian A. Roelofs, Johns Hopkins University
John Gallagher, PMB, Johns Hopkins University
Anna Vagstad, CBI, Johns Hopkins University
 
Postdoctoral Students
Nicholas Zagorski, Johns Hopkins University, Research Mentor
Salva Casares, Johns Hopkins University, Research Mentor
 
Faculty
Dr. Ira J. Ropson, Pennsylvania State University, 09/2004 - 08/2005 Sabbatical
 

PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Student
2004 Course Development, Functional Interpretation of Biological Structures 020.676, Johns Hopkins University
2004 Graduate Program Co-Founder, Chemical Biology Graduate Training Program, Schools of Engineering, Medicine, Public Health, Arts & Sciences, Johns Hopkins University
2004 Course Development, NMR Data Processing & Analysis 020.684, Johns Hopkins University
 
Research Programs
2006 Protein Society Annual Symposia, Organizer and Reviewer, Mock NIH Grant Review Workshop
2006 Protein Society Annual Symposia, Panel Member, How to Interview Workshop Panel Member, Career Panel Workshop
2006 Protein Society Annual Symposia, Presenter, Writing Workshop and Scientific Presentation Workshop
2007 Protein Society Annual Symposia, Panel Member, How to Interview Workshop
2007 Protein Society Annual Symposia, Organizer and Reviewer, Mock NIH Grant Review Workshop, Organizer, Career Panel Workshop
2007 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop
2008 Protein Society Annual Symposia. Organizer, Mock NIH Grant Review Workshop, Organizer, How to Interview Workshop, Organizer, Career Panel Workshop
2008 Protein Society Annual Symposia, Presenter, Writing Workshop Presenter, Scientific Presentation Workshop
2009 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop
2009 Protein Society Annual Symposia, Organizer, Mock NIH Grant Review Workshop, Organizer, Career Panel Workshop
2009 Protein Society Annual Symposia, Panel Member, How to Interview Workshop
2010 Protein Society Annual Symposia, Organizer, Mock NIH Grant Review Workshop, Organizer, How to Interview Workshop, Organizer, Career Panel Workshop
2010 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop
2011 Protein Society Annual Symposia, Presenter, Writing Workshop, Presenter, Scientific Presentation Workshop
2011 Protein Society Annual Symposia, Organizer, Mock NIH Grant Review Workshop, Organizer, How to Interview Workshop, Organizer, Career Panel Workshop
 
 
 

COMMUNITY SERVICE ACTIVITIES:
2005 - 2010 Advisor on college admissions to high school students
2006 - 2008 Volunteer, Facility Committee, Baltimore Montessori Public Charter School
2008 - 2011 Volunteer, IT Committee, Baltimore Montessori Public Charter School
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. R.W. Kriwacki, R.B. Hill, J.M. Flanagan, J.P. Caradonna, and J.H. Prestegard, "New NMR methods for the characterization of bound waters in macromolecules", J Am Chem Soc 115, 8907-8911 (1993).
2. B.D. Albertson, R.B. Hill, K.A. Sprague, K.E. Wood, L.K. Nieman, and D.L. Loriaux, "The effect of the antiglucocorticoid RU486 on adrenal steroidogenic enzyme activity and steroidogenesis", Eur J Endocrinol 130, 195-200 (1994).
3. M. Andrec, R.B. Hill, and J.H. Prestegard, "Amide exchange rates in Escherichia coli Acyl Carrier Protein: correlation with protein structure and dynamics", Protein Sci 4, 983-993 (1995).
4. R.B. Hill, J.M. Flanagan, and J.H. Prestegard, "1H and 15N Magnetic resonance assignments, secondary structure, and tertiary fold of E. coli DnaJ(1-78)", Biochemistry 34, 5587-5595 (1995).
5. R.B. Hill, K.R. MacKenzie, J.M. Flanagan, and J.H. Prestegard, "Overexpression, purification, and characterization of E. coli Acyl Carrier Protein and two mutant proteins", Protein Exp and Purif 66, 394-400 (1995).
6. R.B. Hill and W.F. DeGrado, "Solution structure of α2D, a nativelike de novo designed protein", J Am Chem Soc 120, 1138-1145 (1998).
7. R.B. Hill, J-K Hong, and W.F. DeGrado, "A hydrogen bonding cluster can specify the unique conformation of a protein", J Am Chem Soc 122, 746-747 (2000).
8. R.B. Hill and W.F. DeGrado, "A polar, solvent-exposed residue can be essential for native protein structure", Structure 8, 471-479 (2000).
9. R.B. Hill, C. Bracken, W.F. DeGrado, and A.G. Palmer, "Molecular motions and protein folding: Characterization of the backbone dynamics and folding equilibrium of α2D by 13C NMR spin relaxation methods", J Am Chem Soc 122, 11610-11619 (2000).
10. D.A. Salom, R.B. Hill, J.D. Lear, and W.F. DeGrado, "pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus", Biochemistry 39, 14160-14170 (2000).
11. M.G. VanderHeiden, X.X. Li, E. Gottlieb, R.B. Hill, C.B. Thompson, and M. Colombini, "Bcl-xL promotes both the open configuration of the VDAC and metabolite passage through the
12. outer mitochondrial membrane", J Biol Chem 276, 19414-19419 (2001).
13. J.A. Dohm, S.J. Lee, J.M. Hardwick, R.B. Hill*, and A.G. Gittis*, "The cytosolic domain of the human mitochondrial fission protein Fis1 adopts a TPR fold", Proteins 54,153-6 (2004).
14. Y. Fannjiang, W.C. Cheng, S.J. Lee, B. Qi, J. Pevsner, J.M. McCaffery, R.B. Hill, G. Basañez, and J.M. Hardwick, "Mitochondrial fission proteins regulate programmed cell death in yeast.", Genes Dev 18, 2785-97 (2004).
15. G.R. Thuduppathy and R.B. Hill, "Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes", Protein Sci 15, 248-57 (2006).
16. G.R. Thuduppathy, J. W. Craig, V. Kholodenko, A. Schon, and R.B. Hill, "Evidence that membrane insertion of the cytosolic domain of Bcl-xL might be governed by an electrostatic mechanism", J Mol Biol 359,1045-58 (2006).
17. G.R. Thuduppathy, O. Terrones, J. W. Craig, G. Basañez, and R.B. Hill, "The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner", Biochemistry 45,14533-42 (2006).
18. F.J. Tan, J.E. Zuckerman, A.Z. Fire, and R.B. Hill, "Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain", Cell Death Differ 14,1925-35 (2007).
19. R.C. Wells, L.K. Picton, S.C.P. Williams, F.J. Tan, and R.B. Hill, "Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm.", J Biol Chem 282, 33769-75 (2007).
20. L.J. Siskind, L. Feinstein, T. Yu, J.S. Davis, D. Jones, J. Choi, J.E. Zuckerman, W. Tan, R. B. Hill, J.M. Hardwick, and M. Colombini "Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels", J Biol Chem 283, 6622-6630 (2008).
21. D.A. De Cotiis, M.P. Woll, T.E. Fox, R.B. Hill, R. Levenson, J.M. Flanagan, "Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli." Protein Expr Purif 61, 103-12 (2008).
22. F.J. Tan, M. Husain, C.M. Manlandro, M. Koppenol, A.Z. Fire, & R.B. Hill, "CED-9 and mitochondrial homeostasis in C. elegans muscle. J Cell Sci 102, 3373-82 (2008).
23. M.M. Parrott, S.A. Sitarski, R.J. Arnold, L.K. Picton, R.B. Hill, and S. Mukhopadhyay. "Role of conserved cysteines in the alphavirus E3 protein. J Virol 83, 2584-91 (2009).
24. L.K. Picton, S. Casares, A.C. Monahan, A. Majumdar, & R.B. Hill, "Evidence for conformational heterogeneity of fission protein Fis1 from S. cerevisiae", Biochemistry 48, 6598-609 (2009).
25. C.R. Chang†, C.M. Manlandro†, D. Arnoult, J. Stadler, A.E. Posey, R.B. Hill*, and C. Blackstone*, "A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher-order assembly and mitochondrial division", J Biol Chem 285, 32494-503 (2010).
26. F.J. Tan, J.E. Zuckerman, R.C. Wells, R.B. Hill, "The C. elegans B-cell lymphoma 2 (bcl-2) homolog Cell death abnormal 9 (CED-9) associates with and remodels lipid membranes", Protein Sci 20, 62-74 (2011).
27. D.V. Jeyaraju, H.M. McBride, R.B. Hill*, L. Pellegrini*, "Structural and mechanistic basis of Parl activity and regulation", Cell Death Differ 18, 1531-9 (2011).
28. R.C. Wells and R.B. Hill, "The Fis1 cytosolic domain binds and reversibly clusters lipid vesicles", PLoS-1, 6, e21384 (2011). doi:10.1371/journal.pone.0021384
29. J.E. Tooley, V. Khangulov, J.P. Lees, J.L. Schlessman, M.C. Bewley, A. Héroux, J. Bosch*,
30.
31. J.P. Lees, C.M. Manlandro, L.K. Picton, A.Z.E. Tan, S. Casares, J.M. Flanagan, K.G.
32. Fleming, and R.B. Hill, "A designed point mutant in Fis1 disrupts dimerization and
33. mitochondrial fission", J Mol Biol, 423,143-58 (2012). doi: 10.1016/j.jmb.2012.06.042
34. A.R. Diers, K.A. Broniowska, C.F. Chang, R.B. Hill, N. Hogg, "S-Nitrosation of monocarboxylate transporter 1: Inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells", Free Rad Biol Med 69:229-38 (2014).
35. †co-first authors *co-corresponding authors
 
Books, Chapters, and Reviews
1. E.T. Lally, R.B. Hill, I.R. Kieba, and J. Korostoff, "The interaction between RTX Toxins and target cells", Trends Microbiol 7, 356-361 (1999).
2. R.B. Hill, D.P. Raleigh, A. Lombardi, and W.F. DeGrado, "De novo design of helical bundles as models for understanding protein folding and function", Acc Chem Res 33, 745-754 (2000).
3. G.R. Thuduppathy and R.B. Hill, "Applications of NMR Spin Relaxation Methods for Measuring Biological Motions", Methods Enzymol 384, 243-64 (2004).
4. Hill R.B., Pellegrini L. "The PARL family of mitochondrial rhomboid proteases."