Medical College of Wisconsin
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CURRICULUM VITAE

Seung Min Shin PhD
Assistant Professor
Department of Anesthesiology
Division of Research

OFFICE ADDRESS:
Medical Education Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
03/1993 - 02/1997 BS, Kunsan National University, Kunsan, South Korea
03/1997 - 02/1999 MS, Sungkyunkwan University, Seoul, South Korea
03/2000 - 08/2006 PhD, School of Medicine Catholic University, Seoul, South Korea

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
09/2006 - 11/2006 Research assistance, Molecular Genetic Laboratory, Catholic Research Institutes of Medical Science, The College of Medicine, The Catholic University of Korea, Seoul, South Korea
12/2006 - 03/2017 Postdoctoral Fellow, Department of Pharmacology and Toxicology, The Medical College of Wisconsin, Milwaukee, WI
05/2017 - 04/2020 Research associate I, Department of Anesthesiology, Medical college of Wisconsin, Milwaukee, WI
05/2020 - 04/2022 Research scientist I, Department of Anesthesiology, Medical college of Wisconsin, Milwaukee, WI
05/2022 - Present Research scientist II, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI
08/2024 - Present Assistant Professor, Department of Anesthesiology, Medical college of Wisconsin, Milwaukee, WI

MILITARY SERVICE:
None

FACULTY APPOINTMENTS:
08/01/2024 - Present Assistant Professor, Anesthesiology, Research, Medical College of Wisconsin, Medical Education Building 8701 Watertown Plank Road, Milwaukee, WI 53226

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
09/1997 - 02/1999 Korean Drosophila Society
09/1997 - 02/1999 Genetics Society of Korea
09/1997 - 09/2015 Korean Society for Molecular and Cellular Biology (KSMCB)
06/2009 - Present American Society for Neuroscience (SFN)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Development of a dual Nav1.7 and Nav1.8 blocking
Source:
AHW-Research and Education Program
Role & Effort:
Co-Investigator
PI:
Hongwei Yu
Dates:
01/01/2024 - 12/31/2024
  
Title:
Initial translational development of sensory neuron-specific inhibition of sodium channels for pain therapy
Source:
Falk Medical Research Trust
Role & Effort:
Co-Investigator
PI:
Hongwei Yu
Dates:
01/31/2024 - 01/30/2027
  
Title:
Molecular engagement of CaV3.2 peptide aptamers in human iPSC-derived sensory neurons
Source:
NIH-Neurological Disorders and Stroke
Role & Effort:
Co-Investigator
PI:
Hongwei Yu
Dates:
04/01/2024 - 03/31/2029
  
Title:
Pain Mechanisms in Fabry Disease
Source:
NIH-Neurological Disorders and Stroke
Role & Effort:
Research staff
PI:
Cheryl Stucky
Dates:
04/01/2024 - 03/31/2026
  
Title:
Schwann cell Piezo1 and pain sensation
Source:
NIH-Neurological Disorders and Stroke
Role & Effort:
Co-Investigator
PI:
Hongwei Yu
Dates:
07/01/2024 - 06/30/2026
  
Prior
Peer Review
Title:
Pain Mechanisms in Fabry Disease
Source:
NIH-Neurological Disorders and Stroke
Role & Effort:
Research staff
PI:
Cheryl Stucky
Dates:
04/01/2019 - 03/31/2024
  
Title:
Primary sensory neuron-specific Cav3.2 blockade for DPNP pain therapy
Source:
Neuroscience Research center
Role & Effort:
Research staff
PI:
Hongwei Yu
Dates:
07/01/2019 - 06/30/2020
  
Title:
Primary sensory neuron-targeted block of Cav3.2 for treatment of chronic neuropathic pain
Source:
NIH-Neurological Disorders and Stroke
Role & Effort:
Co-Investigator
PI:
Hongwei Yu
Dates:
07/01/2021 - 07/31/2024
  
Title:
A novel analgesic approach for chronic pain: small peptide inhibition of Nav1.7 in anatomically targeted sensory neurons
Source:
Falk Medical Research Trust Catalyst Award Program
Role & Effort:
Research staff
PI:
Hongwei Yu
Dates:
11/30/2021 - 11/29/2023
  
Title:
Translational Dissection of Cav3.2iPA Molecule Engagement in Human iPSC-derived Sensory Neurons
Source:
AHW-Research and Education Program
Role & Effort:
Research staff
PI:
Hongwei Yu
Dates:
01/01/2023 - 12/31/2023
  
Non-Peer Review
Title:
Mirata Pharmaceuticals
Source:
Mirata Pharmaceuticals LLC
Role & Effort:
Research staff
PI:
Hongwei Yu
Dates:
11/01/2020 - 07/31/2021
  
Title:
Fast green (0.1%) effect on AAV transduction on NG108-15 cells.
Source:
Mirata Phamaceuticals LLC
Role & Effort:
Research staff
PI:
Hongwei Yu
Dates:
09/30/2021 - 01/31/2022
  
Title:
Characterization of AAV-Olig001 vector for gene delivery into Schwann cells
Source:
Myrtelle
Role & Effort:
Research stuff
PI:
Hongwei Yu
Dates:
02/07/2022 - 08/06/2022
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
1. Pain Editor's Choice Video presenter "Targeting intrinsically disordered regions facilitates discovery of CaV3.2 inhibitory peptides for AAV-mediated peripheral analgesia.", Pain.2022 December.
TEACHING ACTIVITIES:
Graduate Students
Qiu, Chensheng (Ph. D), Qingdao University School of Medicine, China, 2019-2020
03/1997 - 02/1999, Sungkyunkwan University, Seoul, South Korea
Taught Molecular Biology and Genetics.
Cai, Yongsong (Ph.D.), Xi'an Jiaotong University, China, 2018-2019
Undergraduate Students Education
 
National
1. Poster presenter, "Satellite glial cells in sensory ganglia express functional TRPA1 that is sensitized in neuropathic and inflammatory pain". Society of Neuroscience 50th annual meeting, Chicago, Oct. 12-16, 2019.
 

PATENT:
Yu H and Shin SM. Sodium channel 1.7 inhibitory peptide for treatment of chronic pain. Filed by MCW IP office. (U.S. Provisional Patent Application No. 63/495,946).


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Shin SM., Itson-Zoske B., Qiu C., Fan F., Xiao Y., Cummins T.R.,Hogan QH. and Yu H. Peripheral-targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels in rat. J Clin Invest. 2024. doi.org/10.1172/JCI170813.
2. Tang C, Zhang H, Border JJ, Liu Y, Fang X, Jefferson JR, Gregory A, Johnson C, Lee TJ, Bai S, Sharma A, Shin SM, Yu H, Roman RJ, Fan F. Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging. Geroscience 2024 Jan 10. doi: 10.1007/s11357-024-01061-y.PMID: 38200357; Scopus ID:2-s2.0-85182225045.
3. Fang X, Tang C, Zhang H, Border JJ, Liu Y, Shin SM, Yu H, Roman RJ, Fan F. Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease. GeroScience June 2023;45(3):1471-1490. doi: 10.1007/s11357-023-00773-x.Scopus ID: 2-s2.0-85150306159.
4. Shin SM, Wang F, Qiu C, Itson-Zoske B, Hogan QH, Yu H. Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain. Gene Ther. 2022 Feb;29(1-2):1-15. doi: 10.1038/s41434-020-0157-5. Epub 2020 May 18. PubMed PMID: 32424233; PubMed Central PMCID: PMC7671947.
5. Shin SM., Itson-Zoske B., Qiu C, Hao X, Fan F, Hogan QH, Yu H. Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain. Arthritis Research & Therapy 2022 Jul.24:168. doi:10.1186/s13075-022-02856-0.
6. Shin SM, Lauzadis J, Itson-Zoske B, Cai YS, c, Fan F, Natarajan G, Kwok WM, Puopolo M, Hogan QH, Yu H. Targeting intrinsically disordered regions facilitates discovery of CaV3.2 inhibitory peptides for AAV-mediated peripheral analgesia. Pain. 2022 Dec; 163(12): 2466-2484. doi: 10.1097/j.pain.0000000000002650. PMID: 35420557; PMCID: PMC9562599.
7. Kearney G, Grau D, Nieves Torres D, Shin SM, Lee SH. S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner. Sci Rep. 2022 Mar 08;12(1):4090. doi: 10.1038/s41598-022-08220-1. PMID: 35260764; PMCID: PMC8904762.
8. Shin SM, Moehring F, Itson-Zoske B, Fan F, Stucky CL, Hogan QH, Yu H. Piezo2mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain. Pain. 2021 Nov 1;162(11):2750-2768. doi: 10.1097/j.pain.0000000000002356. PMID: 34285153; PMCID: PMC8526381.
9. Shin SM, Skaar S, Danielson E, Lee SH. Aberrant expression of S-SCAM causes the loss of GABAergic synapses in hippocampal neurons. Sci Rep. 2020 Jan 9;10(1):83. doi: 10.1038/s41598-019-57053-y. PMID: 31919468; PMCID: PMC6952429.
10. Shin SM, Cai Y, Itson-Zoske B, Qiu C, Hao X, Xiang H, Hogan QH, Yu H. Enhanced T-type calcium channel 3.2 activity in sensory neurons contributes to neuropathic-like pain of monosodium iodoacetate-induced knee osteoarthritis. Mol Pain. 2020 Jan- Dec;16:1744806920963807. doi: 10.1177/1744806920963807. PMID: 33054557; PMCID: PMC7570798.
11. Shin SM, Itson-Zoske B, Cai Y, Qiu C, Pan B, Stucky CL, Hogan QH, Yu H. Satellite glial cells in sensory ganglia express functional transient receptor potential ankyrin 1 that is sensitized in neuropathic and inflammatory pain. Mol Pain. 2020 Jan-Dec;16:1744806920925425. doi: 10.1177/1744806920925425. PMID: 32484015; PMCID: PMC7268132.
12. Yu H, Shin SM, Wang F, Xu H, Xiang H, Cai Y, Itson-Zoske B, Hogan QH. Transmembrane protein 100 is expressed in neurons and glia of dorsal root ganglia and is reduced after painful nerve injury. Pain Rep. 2019 Jan-Feb;4(1):e703. doi: 10.1097/PR9.0000000000000703. eCollection 2019 Jan-Feb. PubMed PMID: 30801043; PubMed Central PMCID: PMC6370145.
13. Yu H, Shin SM, Xiang H, Chao D, Cai Y, Xu H, Khanna R, Pan B, Hogan QH. AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain. Gene Ther. 2019 Aug;26(7-8):308-323. doi: 10.1038/s41434-019-0082-7. Epub 2019 May 22. PubMed PMID: 31118475; PubMed Central PMCID: PMC6707887.
14. Xiang H, Xu H, Fan F, Shin SM, Hogan QH, Yu H. Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno-associated virus delivery in adult rats. J Neurosci Res. 2018 Mar;96(3):436-448. doi: 10.1002/jnr.24183. Epub 2017 Sep 23. PubMed PMID: 28941260; PubMed Central PMCID: PMC5766685.
15. Lee SH, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Heo WD, Kim DW, Yeo CY, Kim CH, Liu QS. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018 Aug 24;9(1):3434. doi: 10.1038/s41467-018-05858-2. PubMed PMID: 30143647; PubMed Central PMCID: PMC6109165.
16. Zhang N, Zhong P, Shin SM, Metallo J, Danielson E, Olsen CM, Liu QS, Lee SH. S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. J Neurosci. 2015 Feb 4;35(5):1892-904. doi: 10.1523/JNEUROSCI.3658-14.2015. PubMed PMID: 25653350; PubMed Central PMCID: PMC4315826.
17. Danielson E, Zhang N, Metallo J, Kaleka K, Shin SM, Gerges N, Lee SH. S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors. J Neurosci. 2012 May 16;32(20):6967-80. doi: 10.1523/JNEUROSCI.0025-12.2012. PubMed PMID: 22593065; PubMed Central PMCID: PMC3365591.
18. Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DT, Sheng M, Lee SH. GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. Nat Neurosci. 2012 Dec;15(12):1655-66. doi: 10.1038/nn.3259. Epub 2012 Nov 11. PubMed PMID: 23143515; PubMed Central PMCID: PMC3804128.
19. Ha SA, Kim HK, Yoo JA, Kim S, Shin SM, Gong GH, Lee YK, Kim JW. HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers. Mol Carcinog. 2014 Jan;53(1):30-7. doi: 10.1002/mc.21945. Epub 2012 Jul 31. PubMed PMID: 22851403.
20. Lee YS, Ha SA, Kim HJ, Shin SM, Kim HK, Kim S, Kang CS, Lee KY, Hong OK, Lee SH, Kwon HS, Cha BY, Kim JW. Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. Exp Mol Pathol. 2010 Feb;88(1):138-42. doi: 10.1016/j.yexmp.2009.09.015. Epub 2009 Oct 8. PubMed PMID: 19818763.
21. Ha SA, Kim HK, Yoo J, Kim S, Shin SM, Lee YS, Hur SY, Kim YW, Kim TE, Chung YJ, Jeun SS, Kim DW, Park YG, Kim J, Shin SY, Lee YH, Kim JW. Transdifferentiation-inducing HCCR-1 oncogene. BMC Cell Biol. 2010 Jun 30;11:49. doi: 10.1186/1471-2121-11-49. PubMed PMID: 20591135; PubMed Central PMCID: PMC2909153.
22. Ha SA, Lee YS, Shin SM, Kim HK, Kim S, Namkoong H, Kim HJ, Jung SM, Lee YS, Chung YJ, Jung SS, Kim JW. Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status. BMC Cancer. 2009 Feb 11;9:51. doi: 10.1186/1471-2407-9-51. PubMed PMID: 19208263; PubMed Central PMCID: PMC2672955.
23. Ha SA, Shin SM, Kim HK, Kim S, Namkoong H, Lee YS, Kim HJ, Jung SM, Lee YS, Chung YJ, Park YG, Jung SS, Kim JW. Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity. J Cell Mol Med. 2009 Sep;13(9B):3868-75. doi: 10.1111/j.1582-4934.2009.00652.x. PubMed PMID: 20196787; PubMed Central PMCID: PMC4516534.
24. Ha SA, Shin SM, Lee YJ, Kim S, Kim HK, Namkoong H, Lee H, Lee YS, Cho YS, Park YG, Jeon HM, Oh C, Kim JW. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization. Int J Cancer. 2008 Feb 1;122(3):501-8. doi: 10.1002/ijc.23146. PubMed PMID: 17943721.
25. Cho GW, Shin SM, Kim HK, Ha SA, Kim S, Yoon JH, Hur SY, Kim TE, Kim JW. HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis. BMC Cell Biol. 2007 Nov 28;8:50. doi: 10.1186/1471-2121-8-50. PubMed PMID: 18045496; PubMed Central PMCID: PMC2222240.
26. Chung YJ, Kim TM, Kim DW, Namkoong H, Kim HK, Ha SA, Kim S, Shin SM, Kim JH, Lee YJ, Kang HM, Kim JW. Gene expression signatures associated with the resistance to imatinib. Leukemia. 2006 Sep;20(9):1542-50. doi: 10.1038/sj.leu.2404310. Epub 2006 Jul 20. PubMed PMID: 16855633.
27. Shin SM, Chung YJ, Oh ST, Jeon HM, Hwang LJ, Namkoong H, Kim HK, Cho GW, Hur SY, Kim TE, Lee YS, Park YG, Ko J, Kim JW. HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon Carcinogenesis. Gastroenterology. 2006 Jun;130(7):2074-86. doi: 10.1053/j.gastro.2006.03.055. PubMed PMID: 16762630.
28. Cho GW, Shin SM, Namkoong H, Kim HK, Ha SA, Hur SY, Kim TE, Chai YG, Kim JW. The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression. Gene. 2006 Dec 15;384:18-26. doi: 10.1016/j.gene.2006.07.006. Epub 2006 Jul 20. PubMed PMID: 16949218.
29. Shin SM., Namkoong H., Kim HK, Ha SA, Cho GW, Hur SY, Kim TE, Kim JW. The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein. BMC Cancer. 2006 Mar 18;6:74. doi: 10.1186/1471-2407-6-74. PubMed PMID: 16545136; PubMed Central PMCID: PMC1459871.
30. Jung SS, Park HS, Lee IJ, Namkoong H, Shin SM, Cho GW, Ha SA, Park YG, Lee YS, Ko J, Kim JW. The HCCR oncoprotein as a biomarker for human breast cancer. Clin Cancer Res. 2005 Nov 1;11(21):7700-8. doi: 10.1158/1078-0432.CCR-04-2609. PubMed PMID: 16278390.
31. Ko J, Shin SM, Oh YM, Lee YS, Ryoo ZY, Lee YH, Na DS, Kim JW. Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene. 2004 Mar 11;23(10):1950-3. doi: 10.1038/sj.onc.1207356. PubMed PMID: 14691448.
32. Ha SA, Shin SM, Namkoong H, Lee H, Cho GW, Hur SY, Kim TE, Kim JW. Cancer-associated expression of minichromosome maintenance 3 gene in several human cancers and its involvement in tumorigenesis. Clin Cancer Res. 2004 Dec 15;10(24):8386-95. doi: 10.1158/1078-0432.CCR-04-1029. PubMed PMID: 15623617.
33. Ko J, Lee YH, Hwang SY, Lee YS, Shin SM, Hwang JH, Kim J, Kim YW, Jang SW, Ryoo ZY, Kim IK, Namkoong SE, Kim JW. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene. 2003 Jul 24;22(30):4679-89. doi: 10.1038/sj.onc.1206624. PubMed PMID: 12879013.
34. Kim TE, Kim YW, Hwang SY, Shin SM, Shin JW, Lee YH, Shin SY, Han KT, Lee JM, Namkoong SE, Kim JW. Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. Int J Cancer. 2002 Feb 20;97(6):780-6. doi: 10.1002/ijc.10124. PubMed PMID: 11857354.
35. Tang C, Zhang H, Border JJ, Liu Y, Fang X, Jefferson JR, Gregory A, Johnson C, Lee TJ, Bai S, Sharma A, Shin SM, Yu H, Roman RJ, Fan F. Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging. Geroscience. 2024 Jun;46(3):3135-3147. PMCID: PMC11009215
36. Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu H, Stucky CL. Keratinocyte Piezo1 drives paclitaxel-induced mechanical hypersensitivity. bioRxiv. 2023 Dec 13. PMCID: PMC10760029
37. Tang C, Zhang H, Border JJ, Liu Y, Fang X, Jefferson JR, Gregory A, Johnson C, Lee TJ, Bai S, Sharma A, Shin SM, Yu H, Roman RJ, Fan F. Role of <i>Dusp</i>5 KO on Vascular Properties of Middle Cerebral Artery in Rats. bioRxiv. 2023 Dec 06. PMCID: PMC10723354
38. Itson-Zoske B, Gani U, Mikesell A, Qiu C, Fan F, Stucky C, Hogan Q, Shin SM, Yu H. Selective RNAi-silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury. Res Sq. 2023 Oct 16. PMCID: PMC10602140
39. Fang X, Tang C, Zhang H, Border JJ, Liu Y, Shin SM, Yu H, Roman RJ, Fan F. Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer’s disease GeroScience. June 2023;45(3):1471-1490.
40. Shin SM, Itson-Zoske B, Fan F, Gani U, Rahman M, Hogan QH, Yu H. Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels. Mol Pain. 2023;19:17448069231174315. PMCID: PMC10240879
41. Tang C, Border JJ, Zhang H, Gregory A, Bai S, Fang X, Liu Y, Wang S, Hwang SH, Gao W, Morgan GC, Smith J, Bunn D, Cantwell C, Wagner KM, Morisseau C, Yang J, Shin SM, O'Herron P, Bagi Z, Filosa JA, Dong Y, Yu H, Hammock BD, Roman RJ, Fan F. Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat Models. bioRxiv. 2024 Aug 31. PMCID: PMC11383657
42. Mikesell AR, Isaeva E, Schulte ML, Menzel AD, Sriram A, Prahl MM, Shin SM, Sadler KE, Yu H, Stucky CL. Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity. Sci Transl Med. 2024 Dec 11;16(777):eadn5629.