CURRICULUM VITAE
Stephanie Olivier-Van Stichelen PhD
Stephanie Olivier-Van Stichelen PhD
Assistant Professor
Department of Biochemistry
Department of Biochemistry
OFFICE ADDRESS: |
Basic Science Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
09/01/2004 - 06/01/2007 B.S., Catholic University of Lille, Lille, FRANCE |
09/01/2009 - 12/12/2012 Ph.D., University of Lille 1, Villeneuve d'Ascq, FRANCE |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
02/01/2013 - 01/31/2019 Post-doctoral Fellow, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Cell and Molecular Biology, National Institute of Health, Bethesda, MD 20892 |
FACULTY APPOINTMENTS: |
02/01/2019 - Present Assistant Professor, Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226 |
04/25/2022 - Present Assistant professor (secondary), Department of Obstetrics and Gynecology, Medical College of Wisconsin |
AWARDS AND HONORS: |
05/2011 - Present Travel award, International glycobiology meeting |
05/2014 - Present Poster award, NIH-FDA glycosciences Research day |
02/2015 - Present Mentor award, National Institute of Health |
04/2016 - Present "Teacher who made the difference" award, University of Kentucky |
02/2017 - Present Poster award, NIH-Japan Biomedical Research Symposium |
12/2020 - Present Outstanding Medical Student Award, Medical College of Wisconsin |
12/2020 - Present Outstanding Graduate Student Award, Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
11/01/2014 - Present Society of Glycobiology (Member) |
01/01/2019 - Present ASBMB (Member) |
10/19/2021 - Present The Endocrine Society (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
02/2021 - Present Guest Editor, Frontiers in Molecular Biosciences |
Journal Review |
01/01/2017 - Present Frontiers in Endocrinology |
05/01/2018 - Present Frontiers in Microbiology |
05/01/2019 - Present Nutrient |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
09/2009 - 12/2012 Ph.D. representative, Institute Board, Unit of Structural and Functional Glycobiology |
09/2010 - 12/2012 Chair, Journal club, Unit of Structural and Functional Glycobiology |
06/2013 - 09/2017 Chair, Visiting Fellows Committee(VFC), National Institute of Health |
06/2013 - 09/2018 Chair, French NIH association(Fr@NIH), National Institute of Health |
03/01/2019 - 09/01/2021 Biochemistry dpt representative, Faculty council, Medical College of Wisconsin |
05/01/2019 - Present Biochemistry Liaison, Office of global health, Medical College of Wisconsin |
09/15/2020 - Present member, Biochemistry Graduate Studies Committee, Medical College of Wisconsin |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
06/01/2021 - Present member, Education Committee, Society for Glycobiology |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
04/01/2019 - 03/30/2020 Ambassador, eLife |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin, a novel marker of early colorectal cancer?, Autonomous University of Oaxaca, Oaxaca, Mexico, 03/2011 - Present |
Nutrient sensing O-GlcNAc cycling impacts neurodevelopmental timing and metabolism - Sendai, Japan, NIH-Japan Biomedical research symposium, Sendai, Japan, 02/2017 - Present |
Nutritive and Non-Nutritive sweeteners in development of metabolic homeostasis, Medical College of Wisconsin seminar series, Milwaukee, WI, USA, 06/2017 - Present |
Investigating Sugars and Artificial Sweeteners Exposure in Pregnancy and Lactation, WHRP Seminar series, Medical College of Wisconsin, 12/18/2018 |
Sugars and artificial sweeteners in pregnancy and early life, Pediatric Pathology seminar series, Medical College of Wisconsin, 11/24/2021 - Present |
Nutrient-dependent O-GlcNAcylation in early metabolic development and pregnancy complications, CVC ATVB Signature Program meeting, Medical College of Wisconsin(Virtual), 04/18/2022 - Present |
National |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin, a novel marker of early colorectal cancer?, UNAM, Mexico city, Mexico, 03/2011 - Present |
Nutritive and Non-Nutritive sweeteners in development of metabolic homeostasis, UNC Chapel hill Seminar series, Kannapolis, NC, USA, 11/2016 - Present |
Maternal exposure to non-nutritive sweeteners impacts infant metabolism and nascent microbiome, 2018 Glycobiology SIG Workshop, Bethesda, MD, USA, 09/2018 - Present |
Linking maternal sugar consumption to progeniesa?? developmental defect: a focus on OTX2a??s O-GlcNAcylation, Satellite meeting of the Society of Glycobiology meeting 2019: Tools in Glycoscience: Glycan Expression and Function, Phoenix, AZ, 11/02/2019 - Present |
O-GlcNAcylation in early development: resource and research, Graduate School Seminar Series of Oaxaca School of Medecine, Oaxaca, Mexico, 02/26/2021 - Present |
International |
O-GlcNAcylation and beta-catenin, European Research Network, GDRE, Lille, France, 06/2010 - Present |
Sugars and Artificial Sweeteners in Development of Metabolic Homeostasis, Quadram Institute Bioscience serminar series, Dundee, UK, 05/18/2017 - Present |
O-GlcNAcylation in early development: resource and research, Faculty of medecine and surgery of the Universidad Benito Juarez de Oaxaca, Virtual, 02/26/2021 - Present |
SWEETENERS EXPOSURE IN EARLY DEVELOPMENT: SAFE OR NOT, UGSF seminar series, University of Lille, France, 09/16/2021 - Present |
O-GlcNAcylation in the pituitary gland: From
development to endocrine function, 6th Latin American Glycobiology Congress, Virtual, 10/06/2021 - Present |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Local |
O-GlcNAcylation and beta-catenin, Genomic of cancer symposium, Lille, France, 01/2010 - Present |
A complex interplay between X-inactivation to Barr bodies and regulation of the Xist-proximal gene O-linked GlcNAc Transferase (OGT), NIH FDA glycosciences research day, Bethesda, MD, USA, 05/2014 - Present |
Disruption of Brain O-GlcNAc cycling induces OTX2-dependent developmental delay, NIH FDA glycosciences research day, Bethesda, MD, USA, 04/2015 - Present |
Disruption of Brain O-GlcNAc cycling induces OTX2-dependent developmental delay, NIH FDA glycosciences research day, Bethesda, MD, USA, 06/2016 - Present |
Maternal exposure to non-nutritive sweeteners adversely impacts infant metabolism and nascent microbiome, NIH FDA glycosciences research day, Bethesda, MD, USA, 02/2018 - Present |
Investigating sugars and artificial sweeteners exposure in pregnancy and lactation, OBGYN seminar series, Medical College of Wisconsin, 12/18/2019 - Present |
Regional |
Linking maternal sugar consumption to progeniesa?? developmental defect: a focus on OTX2a??s O-GlcNAcylation., Great Lakes Glycomics Symposium, Versiti, Blood research institute, Milwaukee, 05/31/2019 - Present |
National |
O-GlcNAcylation and beta-catenin, 3rd Canceropole symposium, Deauville, France, 03/2010 - Present |
O-GlcNAcylation and beta-catenin, MIFOBIO School, Seignosse, France, 09/2010 - Present |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin, a novel marker of early colorectal cancer?, 4th canceropole, Deauville, France, 05/2011 - Present |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin, a novel marker of early colorectal cancer?, 24th French Glycoscience group (GFG), Val Joly, France, 05/2012 - Present |
A complex interplay between X-inactivation to Barr bodies and regulation of the Xist-proximal gene O-linked GlcNAc Transferase (OGT), Society for glycobiology meeting, St. Petersburg, FL, USA, 11/2013 - Present |
A complex interplay between X-inactivation to Barr bodies and regulation of the Xist-proximal gene O-linked GlcNAc Transferase (OGT), Society for glycobiology meeting, Honolulu, HA, USA, 11/2014 - Present |
Nutrient sensing O-GlcNAc cycling impacts neurodevelopmental timing and metabolism, Society for glycobiology meeting, San Francisco, CA, USA, 12/2015 - Present |
Nutrient sensing O-GlcNAc cycling impacts neurodevelopmental timing and metabolism, Society for glycobiology meeting, New Orleans, LA, USA, 11/2016 - Present |
Nascent microbiome and early metabolism are perturbed by pre- and post-natal exposure to artificial sweeteners, Society for glycobiology meeting, Portland, OR, USA, 11/2017 - Present |
International |
O-GlcNAcylation: a new element regulating the properties of beta-catenin, 20th Joint glycobiology meeting, Koln, Germany, 11/2009 - Present |
O-GlcNAcylation and beta-catenin, 21st Joint meeting, Gent, Belgium, 11/2010 - Present |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin, a novel marker of early colorectal cancer?, GLYCO21, Vienna, Austria, 08/2011 - Present |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin,a novel marker of early colorectal cancer?, 22nd joint glycobiology meeting, Lille, France, 11/2011 - Present |
Incidence of O-GlcNAcylation on beta-catenin properties: O-GlcNAcylated beta-catenin, a novel marker of early colorectal cancer?, 10th Jenner Glycobiology and Medicine Symposium, The Hague, Netherland, 03/2012 - Present |
Disruption of Brain O-GlcNAc cycling induces OTX2-dependent developmental delay, GLYCO23, Split, Croatia, 09/2015 - Present |
Nutrient sensing O-GlcNAc cycling impacts neurodevelopmental timing and metabolism, Glycobiology Gordon conference, Ventura, CA, USA, 04/2017 - Present |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Medical Student Education |
09/2019 - Present Amino Acid Metabolism |
Graduate Student Education |
09/2019 - Present Glycobiology |
EXTRAMURAL TEACHING: |
Graduate Student Education |
09/01/2019 - 12/31/2012 University of Lille 1, Biochemistry |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
Eugenia Wulff, Medical College of Wisconsin, 04/2019 - Present Thesis Supervisor |
Ugo Ihenacho, Medical College of Wisconsin, 05/2019 - Present Thesis committee member |
Carla Martinez, Medical College of Wisconsin, 06/01/2019 - 08/01/2019 Research mentor |
Natalia Soledo, Medical College of Wisconsin, 06/01/2019 - 08/01/2019 Research Mentor |
Laura Danner, Medical College of Wisconsin, 04/2020 - Present Thesis supervisor |
Kaitlin Schulz, Medical College of Wisconsin, 05/2020 - Present Thesis committee member |
Wenjing Chen, Medical College of Wisconsin, 05/2020 - Present Thesis committee member |
Lazaro Vergara, Medical College of Wisconsin, 06/01/2021 - 08/01/2021 Research mentor |
Jennifer Nworah, Medical College of Wisconsin, 06/01/2021 - 08/01/2021 Research mentor |
Medical Students |
Logan Massman, Medical College of Wisconsin, 06/2020 - Present Research supervisor |
Raquel Valdes, Medical College of Wisconsin, 06/01/2021 - Present Research mentor |
Clinical/Research Fellows |
Christine Livergood, Medical College of Wisconsin, 12/2019 - Present Thesis committee member |
Yiwen Cui, Medical College of Wisconsin, 06/2020 - Present Research Advisor |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
Katie Pruitt, Thomas Jefferson high school, 06/01/2014 - 09/01/2017 Research mentor |
Alexandra Saks, Quince Orchard high school, 09/2016 - 04/2017 Research mentor |
Undergraduate Students |
Matthieu Jeavon, University of Lille 1, 03/2010 - 06/2010 Research mentor |
Alexandra Zak, University of Lille 1, 03/2011 - 06/2011 Research mentor |
Clement Delanoy, University of Lille 1, 08/01/2011 - 09/01/2011 Research mentor |
Joshua Ohde, University of Kentucky, 07/01/2015 - 09/01/2016 Research mentor |
Razan Bakarman, Catholic University of America, 06/01/2017 - 09/01/2017 Research mentor |
Jeffrey Boakye, National Institute of Health, 11/2017 - Present Research mentor |
Christer Abou Anny, University of Lille, France, 09/01/2020 - Present Research mentor |
Yannick Masson, University of Lille, France, 09/01/2021 - Present Research mentor |
GLOBAL HEALTH ACTIVITIES: |
05/01/2019 - Present Scientific and student exchange agreement with University of Lille |
04/01/2020 - Present International Mentor, PhD fellowhsip University of Lille, Project PEARL |
MEDIA: |
07/31/2019 - Present WUWM 89.7 Milwaukee's NPR
Fit For You: Artificial Sweeteners
https://www.wuwm.com/post/fit-you-artificial-sweeteners#stream/0 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Lefebvre T, Dehennaut V, Guinez C, Olivier S, Drougat L, Mir AM, Mortuaire M, Vercoutter-Edouart AS, Michalski JC. Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease. Biochim Biophys Acta. 2010 Feb;1800(2):67-79. |
2. Olivier S, Mir AM, Michalski JC, Lefebvre T. [Signaling and metabolic predispositions linked to the colorectal cancer]. Med Sci (Paris). 2011 May;27(5):514-20. |
3. Olivier-Van Stichelen S, Guinez C, Mir AM, Perez-Cervera Y, Liu C, Michalski JC, Lefebvre T. The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of I?-catenin and cell proliferation. Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E417-24. |
4. Olivier-Van Stichelen S, Drougat L, Dehennaut V, El Yazidi-Belkoura I, Guinez C, Mir AM, Michalski JC, Vercoutter-Edouart AS, Lefebvre T. Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression. Oncogenesis. 2012 Dec 10;1:e36. PMCID: PMC3545199 |
5. Drougat L, Olivier-Van Stichelen S, Mortuaire M, Foulquier F, Lacoste AS, Michalski JC, Lefebvre T, Vercoutter-Edouart AS. Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition. Biochim Biophys Acta. 2012 Dec;1820(12):1839-48. |
6. Perez-Cervera Y, Dehennaut V, Aquino Gil M, Guedri K, Sol??rzano Mata CJ, Olivier-Van Stichelen S, Michalski JC, Foulquier F, Lefebvre T. Insulin signaling controls the expression of O-GlcNAc transferase and its interaction with lipid microdomains. FASEB J. 2013 Sep;27(9):3478-86. |
7. Lefebvre T, Drougat L, Olivier-Van Stichelen S, Michalski JC, Vercoutter-Edouart AS. Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc. Methods Mol Biol. 2013;1022:147-59. |
8. Olivier-Van Stichelen S, Dehennaut V, Buzy A, Zachayus JL, Guinez C, Mir AM, El Yazidi-Belkoura I, Copin MC, Boureme D, Loyaux D, Ferrara P, Lefebvre T. O-GlcNAcylation stabilizes I?-catenin through direct competition with phosphorylation at threonine 41. FASEB J. 2014 Aug;28(8):3325-38. PMCID: PMC4101651 |
9. Olivier-Van Stichelen S, Abramowitz LK, Hanover JA. X marks the spot: does it matter that O-GlcNAc transferase is an X-linked gene? Biochem Biophys Res Commun. 2014 Oct 17;453(2):201-7. PMCID: PMC4253714 |
10. Abramowitz LK, Olivier-Van Stichelen S, Hanover JA. Chromosome imbalance as a driver of sex disparity in disease. J Genomics. 2014;2:77-88. PMCID: PMC4091450 |
11. Olivier-Van Stichelen S, Hanover JA. X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body. Front Genet. 2014;5:256. PMCID: PMC4120696 |
12. Olivier-Van Stichelen S, Hanover JA. You are what you eat: O-linked N-acetylglucosamine in disease, development and epigenetics. Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):339-45. PMCID: PMC4479189 |
13. Steenackers A, Olivier-Van Stichelen S, Baldini SF, Dehennaut V, Toillon RA, Le Bourhis X, El Yazidi-Belkoura I, Lefebvre T. Silencing the Nucleocytoplasmic O-GlcNAc Transferase Reduces Proliferation, Adhesion, and Migration of Cancer and Fetal Human Colon Cell Lines. Front Endocrinol (Lausanne). 2016;7:46. PMCID: PMC4879930 |
14. Baldini SF, Steenackers A, Olivier-Van Stichelen S, Mir AM, Mortuaire M, Lefebvre T, Guinez C. Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation. Biochem Biophys Res Commun. 2016 09 16;478(2):942-8. |
15. Olivier-Van Stichelen S, Wang P, Comly M, Love DC, Hanover JA. Nutrient-driven <i>O</i>-linked <i>N</i>-acetylglucosamine (<i>O</i>-GlcNAc) cycling impacts neurodevelopmental timing and metabolism. J Biol Chem. 2017 04 14;292(15):6076-6085. PMCID: PMC5391740 |
16. Akan I, Olivier-Van Stichelen S, Bond MR, Hanover JA. Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration. J Neurochem. 2018 01;144(1):7-34. PMCID: PMC5735008 |
17. Olivier-Van Stichelen S, Rother KI, Hanover JA. Maternal Exposure to Non-nutritive Sweeteners Impacts Progeny's Metabolism and Microbiome. Front Microbiol. 2019;10:1360. PMCID: PMC6595049 |
18. Palatnik A, Moosreiner A, Olivier-Van Stichelen S. Consumption of non-nutritive sweeteners during pregnancy. Am J Obstet Gynecol. 2020 08;223(2):211-218. |
19. Palatnik A, Moosreiner A, Olivier-Van Stichelen S. Reply. Am J Obstet Gynecol. 2020 11;223(5):777. |
20. Palatnik A, Moosreiner A, Olivier-Van Stichelen S. Reply. Am J Obstet Gynecol. 2020 12;223(6):953. |
21. Wulff-Fuentes E, Berendt RR, Massman L, Danner L, Malard F, Vora J, Kahsay R, Olivier-Van Stichelen S. The human O-GlcNAcome database and meta-analysis. Sci Data. 2021 01 21;8(1):25. PMCID: PMC7820439 |
22. Malard F, Wulff-Fuentes E, Berendt RR, Didier G, Olivier-Van Stichelen S. Automatization and self-maintenance of the O-GlcNAcome catalog: a smart scientific database. Database (Oxford). 2021 07 19;2021. PMCID: PMC8288053 |
23. Massman LJ, Pereckas M, Zwagerman NT, Olivier-Van Stichelen S. O-GlcNAcylation Is Essential for Rapid Pomc Expression and Cell Proliferation in Corticotropic Tumor Cells. Endocrinology. 2021 12 01;162(12). PMCID: PMC8482966 |
24. Olivier-Van Stichelen S, Malard F, Berendt R, Wulff-Fuentes E, Danner L. Find out if your protein is O-GlcNAc modified: The O-GlcNAc database. FASEB J. 2022 May;36 Suppl 1. |
25. Danner L, Valdes R, Olivier-Van Stichelen S. Non-nutritive sweeteners competitively inhibit P-glycoprotein in liver. FASEB J. 2022 May;36 Suppl 1. |
26. Wulff Fuentes EA, Boakye J, Pereckas M, Berendt R, Hanover JA, Olivier-Van Stichelen S. OTX2's Dual Mode of Degradation is Regulated by O-GlcNAcylation. FASEB J. 2022 May;36 Suppl 1. |
27. Malard F, Danner L, Rouzies E, Meyer JG, Lescop E, Olivier-Van Stichelen S. EpyNN: Educational python for Neural Networks SoftwareX. July 2022;19. |
