CURRICULUM VITAE
Thomas Zahrt PhD, MS
Thomas Zahrt PhD, MS
Emeritus Professor
Department of Microbiology and Immunology
Department of Microbiology and Immunology
OFFICE ADDRESS: |
8701 Watertown Plank Road |
Milwaukee, WI 53226 |
EDUCATION: |
09/1988 - 06/1992 B.A., Kalamazoo College, Kalamazoo, MI |
09/1992 - 05/1994 M.S., University of Illinois, Urbana, IL |
05/1994 - 10/1997 Ph.D., University of Illinois, Urbana, IL |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/1997 - 03/2001 Postdoctoral Fellow, University of Michigan Medical School, Ann Arbor, MI |
FACULTY APPOINTMENTS: |
04/2001 - 06/2007 Assistant Professor, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI |
07/2007 - 06/2009 Associate Professor, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI |
07/2009 - 06/2015 Associate Professor with tenure, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI |
07/2015 - Present Professor with tenure, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI |
ADMINISTRATIVE APPOINTMENTS: |
08/2010 - Present Director, Department of Microbiology and Molecular Genetics Graduate, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
1992 - 1995 Outstanding Teaching Assistant, University of Illinois |
06/1994 - Present American Society for Microbiology |
10/1995 - Present Francis Clark Award, University of Illinois |
06/1997 - Present Harley J. Van Cleave Fellowship, University of Illinois |
10/2001 - Present Pew Biomedical Scholar Nominee, Medical College of Wisconsin |
05/2003 - Present Awardee, Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Disease (1 of 8 total national awardees) |
2008 - 2009 MCW Outstanding Medical School Teaching Award, Medical Microbiology |
2011 - 2012 MCW Outstanding Medical School Teaching Award, Medical Microbiology |
2014 - 2015 MCW Outstanding Medical School Teaching Award, Infectious Agents and Host Immunity |
2015 - 2016 MCW Outstanding Graduate School Teaching Award |
2018 - Present Recipient of Journal of Bacteriology Jack Kenney Award for Outstanding Service on the Editorial Board |
2018 - 2019 MCW Outstanding Graduate School Educator Award |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
06/1994 - Present American Society for Microbiology |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
2005 - 2007 Infection and Immunity |
2008 - 2010 Infection and Immunity |
2010 - Present Frontiers in Microbiology |
2011 - Present Infection and Immunity |
Journal Review |
2001 Doody Publishing Book Reviews |
2002 European Journal of Biochemistry |
2002 Infection and Immunity |
2003 - Present Journal of Clinical Microbiology |
2003 - Present Journal of Bacteriology |
2003 - Present Microbiology |
2003 - Present Molecular Microbiology |
2004 Journal of Biological Chemistry |
2005 FEMS Microbiology Letters |
2005 Emerging Infectious Diseases |
2006 - Present Plos Pathogens |
2006 Clinical and Vaccine Immunology |
2007 Biochimica et Biophysica Acta-General Subjects |
2008 Journal of Microbiological Methods |
2010 Tuberculosis |
2010 Cellular Microbiology |
2010 BMC |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
01/2010 - Present Member Midwest Microbial Pathogenesis Conference Organizing Committee |
09/2012 - Present Co-Organizer 19th Annual Midwest Microbial Pathogenesis Conference, Milwaukee, WI |
07/2014 - Present Member Milwaukee Area Weapons of Mass Destruction (WMD) Networking Group-BSL3/ABSL3 Infrastructure |
08/2014 - Present Member Froederdt & Medical College of Wisconsin Joint Occupational Health Steering Committee |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
01/2003 Ad-hoc Reviewer NSF Exp. Program to Stimulate Competitive Research |
09/2003 Ad-hoc Reviewer NIH IDM-90 Bacterial Biodefense Study Section Panel |
11/2003 Ad-hoc Reviewer The Wellcome Trust Foundation (UK) |
03/2004 Ad-hoc Reviewer Michael Smith Foundation for Health Research (Can) |
06/2004 Ad-hoc Reviewer NIH MBC-1 Study Section |
07/2004 Ad-hoc Reviewer Medical Research Council (UK) |
07/2004 Ad-hoc Reviewer The Wellcome Trust Foundation (UK) |
02/2005 Ad-hoc Reviewer NIH IDM-90 Bacterial Biodefense Study Section Panel |
12/2005 Ad-hoc Reviewer The Wellcome Trust Foundation (UK) |
09/2006 Ad-hoc Reviewer National Science Foundation |
03/2007 Ad-hoc Reviewer National Science Foundation |
06/2007 Ad-hoc Reviewer NIH IDM-90 Bacterial Biodefense Study Section Panel |
11/2007 Ad-hoc Reviewer NIH IDM-90 Bacterial Biodefense Study Section Panel |
06/2008 Ad-hoc Reviewer NIH BACP Study Section |
10/2008 Ad-hoc Reviewer NIH BACP Study Section |
06/2009 Ad-hoc Reviewer NIH IDM-A 02M Special Study Section Members |
01/2010 Ad-hoc Reviewer NIH NICHD Laboratory of Developmental and Molecular Immunity Intramural Review |
06/2010 Ad-hoc Reviewer NIH BACP Study Section |
07/2010 Ad-hoc Reviewer NIH ZRG1 BACP-B (09) Study Section |
10/2010 Ad-hoc Reviewer NIH ZRG1 IDM-80 Study Section |
10/2010 - Present Ad-hoc Reviewer NIH ZRG1 IDM-80 Study Section |
11/2010 Ad-hoc Reviewer NIH ZRG1 IDM-90 Study Section |
02/2013 - Present Ad-hoc Reviewer Postdoctoral Fellows Training Program, Eck Institute for Global Health, University of Notre Dame, South Bend, IN. |
03/2013 - Present Ad-hoc Reviewer NIH Director Early Investigator Independence Award |
10/2014 - Present Ad-hoc Reviewer NIH IDM-M03 Study Section |
03/2016 - Present Ad-hoc Reviewer NIH IDM-S81 AREA application in Infectious Diseases and |
03/2017 - Present Ad-hoc Reviewer NIH IDM-S81 AREA application in Infectious Diseases and |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Zahrt, Thomas C. Mycobacterium tuberculosis persistence requires adaptation within the host, Invited Talk, Congress of the Chilean Society for Microbiology, Punta de Tralca, Chile, 12/2002 |
National |
Zahrt, Thomas C. and V. Deretic, Global Analysis of Mycobacterium tuberculosis Two-Component Signal Transduction Systems, Invited talk, United States-Japan Thirty-Fourth Joint Tuberculosis/Leprosy Conference, San Francisco, CA, 06/1999 |
Springer, B., Master, S., Sander, S., Zahrt, T., McFalone, M., Song, J., Papavinasaundaram, K.G., Colston, M.J., Boettger, E.and V.Deretic, Silencing of Oxidative Stress Response in Mycobacterium tuberculosis: Inactivation of ahpC and Expression Patterns in Virulent and Avirulent Strains, Invited talk, ASM Conference on Tuberculosis: Past, Present, and Future, New York, NY, 06/2000 |
Zahrt, Thomas C., A Global Analysis of Two-Component Signal Transduction Systems in Mycobacterium tuberculosis: Implications for Survival in Macrophages, Invited seminar, University of Massachusetts Medical School, Worchester, MA, 07/2000 |
Zahrt, Thomas C., New plasmids for Francisella, Invited talk, First Annual Tularemia Workshop, Hamilton, MT, 10/2004 |
Zahrt, Thomas C., Characterization of a Transcriptional Program Required for Persistent Infection by Mycobacterium tuberculosis, Invited seminar, Marshall University, Charleston, WV, 11/2004 |
Zahrt, Thomas C., MprA is a Global Stress Regulator in Mycobacterium tuberculosis, Invited seminar, Tulane University, New Orleans, LA, 05/2005 |
Zahrt, Thomas C., Genetic platforms for mutagenesis in Francisella tularensis, Invited speaker, Second Annual Tularemia Workshop, Hancock, MA, 11/2005 |
Zahrt, Thomas C., Regulation of stress response in Mycobacterium tuberculosis, Invited seminar, The Biodesign Institute, Arizona State University, Tempe, AZ, 01/2006 |
Zahrt, Thomas C., Regulation of a stress response program in Mycobacterium tuberculosis, Invited seminar, University of Louisville, Louisville, KY, 09/2006 |
Zahrt, Thomas C., Development of an In Vivo Expression Technology (IVET) system for Francisella tularensis, Invited speaker, National Meeting of the Regional Centers of Excellence, St. Louis, MO, 04/2007 |
Zahrt, Thomas C., Development of an In Vivo Expression Technology (IVET) system for Francisella tularensis, Invited speaker, National Meeting of the Regional Centers of Excellence, St. Louis, MO, 04/2007 - Present |
Zahrt, Thomas C., Francisella tularensis and its potential use as a biological weapon, Invited seminar, Wayne State University, Detroit, MI, 10/2007 |
Zahrt, Thomas C., Regulation of a membrane stress response program in Mycobacterium tuberculosis, Invited Seminar, University of Minnesota, Minneapolis, MN, 11/2007 |
Zahrt, Thomas C., Comparison of LVS delta-purMCD and Schu S4 delta-purMCD auxotrophs as live vaccine candidates for Francisella tularensis, Invited speaker, National Meeting of the Regional Centers of Excellence, St. Louis, MO, 04/2008 |
Zahrt, Thomas C., Defining the role of MprAB two-component system in Mycobacterium tuberculosis virulence, Invited seminar, Walter Reed Army Institute of Infectious Disease Research, Washington DC, 06/2008 |
Zahrt, Thomas C., Defining the role of MprAB two-component system in Mycobacterium tuberculosis virulence, Invited seminar, Walter Reed Army Institute of Infectious Disease Research, Washington DC, 06/2008 - Present |
Zahrt, Thomas C., Identification of gene targets for live attenuated vaccine development in Francisella tularensis, Invited seminar, University of North Carolina, Raleigh-Durham, NC, 04/2010 |
Zahrt, Thomas C., The MprAB two-component system regulates membrane adaptations in Mycobacterium tuberculosis, Invited seminar, Northwestern University, Chicago, IL, 09/2010 |
Zahrt, Thomas C., Generation and application of a transposon mutant library in Francisella tularensis type A strain Schu S4, Invited speaker, National Meeting of the Regional Centers of Excellence, Denver, CO, 04/2011 |
Zahrt, Thomas C., Stress Adaptations and Mycobacterium tuberculosis persistence, Invited Seminar, University of Iowa, Iowa City, IA, 03/2012 - Present |
Zahrt, Thomas C., Regulation of the Cell Envelope Stress Response Network in Mycobacterium tuberculosis by the MprAB Two-Component System, Invited Seminar, University of Rochester, Rochester, NY, 04/2013 - Present |
Zahrt, Thomas C., Survival within the granuloma: Mycobacterium tuberculosis regulates resistance to cell envelope stress, Concordia University, Mequon, WI, 03/2014 - Present |
Zahrt, Thomas C., Lipid droplets and their importance in Mycobacterium tuberculosis persistence and host cell function, University of Wisconsin, Madison, WI, 01/2016 - Present |
Zahrt, Thomas C., Generation and application of a transposon mutant library in Francisella tularensis type A strain Schu S4, Invited speaker, National Meeting of the Regional Centers of Excellence, Denver, CO, - 2011 |
Regional |
Zahrt, Thomas C., A Study of Two-Component Signal Transduction Systems in Mycobacterium tuberculosis, Invited seminar, Andrews University, Berrien Springs, MI, 12/1999 |
Zahrt, Thomas C., Mycobacterium tuberculosis genes important for adaptation within the host, Invited seminar, University of Michigan Medical School, Ann Arbor, MI, 03/2001 |
Zahrt, Thomas C., A regulatory system important for persistent Mycobacterium tuberculosis, Invited speaker, Ninth Annual Midwest Microbial Pathogenesis Meeting, Indianapolis, IN, 09/2002 |
Zahrt, Thomas C., Analysis of a regulatory system important for Mycobacterium tuberculosis persistence, Invited seminar, Northern Illinois University, DeKalb, IL, 09/2002 |
Zahrt, Thomas C., Identification of Francisella virulence factors, Invited speaker, Great Lakes Regional Center of Excellence Annual Meeting, Chicago, IL, 12/2003 |
Zahrt, Thomas C., Regulation of Genes Required for Mycobacterium tuberculosis Persistent Infections, Invited seminar, University of Wisconsin-Parkside, Kenosha, WI, 11/2004 |
Zahrt, Thomas C., Construction of F. tularensis regulatory mutants, Invited speaker, Great Lakes Regional Center of Excellence Product Development Workshop, Chicago, IL, 08/2006 |
Zahrt, Thomas C., Virulence and immunogenicity of a Francisella purine auxotroph, Invited speaker, Great Lakes Regional Centers of Excellence Annual Meeting, Hilton Head, SC, 12/2007 |
Zahrt, Thomas C., Use of purine auxotrophs of Francisella tularensis as live vaccine candidates and surrogate hosts for in vivo expression technology, 15th Annual Midwest Microbial Pathogenesis Meeting, Madison, WI, 10/2008 |
Zahrt, Thomas C., Use of purine auxotrophs of Francisella tularensis as live vaccine candidates and surrogate hosts for in vivo expression technology, Invited speaker, Great Lakes Regional Centers of Excellence Annual Meeting, Hilton Head, SC, 11/2008 |
Zahrt, Thomas C., Generation and application of a transposon mutant library in Francisella tularensis type A strain Schu S4, Invited speaker, Great Lakes Regional Centers of Excellence Annual Meeting, Chicago, IL, 09/2010 |
Zahrt, Thomas C., Identification of Francisella tularensis determinants mediating suppression of cytopathic and pro-inflammatory responses during infection of human lung cells, Invited Speaker, Great Lakes Regional Centers of Excellence Annual Meeting, Chicago, IL, 08/2011 - Present |
Zahrt, Thomas C., Francisella tularensis interactions with human alveolar ATII pneumocytes, Invited Speaker, Great Lakes Regional Centers of Excellence Annual Meeting, Chicago, IL, 08/2012 - Present |
Zahrt, Thomas C., Processing Cell Envelope Stress in Mycobacterium tuberculosis, Opening Seminar, 20th Annual Midwest Microbial Pathogenesis Conference, Ohio State University, Columbus, OH, 09/2013 - Present |
Local |
Zahrt, Thomas C., A Mycobacterium tuberculosis regulatory system important for acute and persistent infection, Invited seminar, Medical College of Wisconsin Department of Biochemistry, Milwaukee, WI, 09/2001 |
Zahrt, Thomas C., A Mycobacterium tuberculosis two-component system important for adaptation within the host, Invited seminar, Milwaukee Microbiology Society, Milwaukee, WI, 09/2001 |
Zahrt, Thomas C., Functional characterization of the MprA response regulator of Mycobacterium tuberculosis, Invited seminar, Milwaukee Microbiology Society, Milwaukee, WI, 04/2003 |
Zahrt, Thomas C., Live attenuated vaccine candidates for Francisella tularensis, Invited seminar, Medical College of Wisconsin Department of Medicine Infectious Disease Conference, Milwaukee, WI, 11/2009 |
Zahrt, Thomas C., Defining the role of lipid droplets in Mycobacterium tuberculosis persistence, Invited Seminar, Medical College of Wisconsin, Department of Medicine Infectious Disease Conference, Milwaukee, WI, 03/2017 - Present |
Zahrt, Thomas C., Lipid droplets in Mycobacterium tuberculosis persistence, Invited Seminar, Medical College of Wisconsin, Department of Biochemistry, Milwaukee, WI, 10/2017 - Present |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
08/2002 - 09/2006 Dean's Appointee, Institutional Care and Use Committee (IACUC), Medical College of Wisconsin |
08/2002 - 08/2004 Member, Student Admission and Welfare Committee, Medical College of Wisconsin |
01/2003 - 12/2003 Chair, Pathogens Committee, Medical College of Wisconsin Institutional Biosafety Committee |
01/2003 - 06/2008 Member, Medical College of Wisconsin Safety Committee |
01/2004 - 09/2009 Member, Biological Safety Level 3 (BSL3) Subcommittee, Medical College of Wisconsin Safety Committee |
01/2004 - 09/2009 Co-chair, Institutional Biosafety Committee (IBC), Medical College of Wisconsin |
11/2005 Member, Advancing a Healthier Wisconsin Initiative Grant Scientific Peer Review Panel, Medical College of Wisconsin |
02/2006 - 12/2006 Member, Center for Biopreparedness and Infectious Disease Faculty Recruitment Committee, Medical College of Wisconsin |
11/2006 Member, Advancing a Healthier Wisconsin Initiative Grant Scientific Peer Review Panel, Medical College of Wisconsin |
03/2007 - 08/2007 Member, Center for Biopreparedness and Infectious Disease Faculty Recruitment Committee, Medical College of Wisconsin |
01/2008 - Present Member, Biomedical Resource Center Advisory Committee, Medical College of Wisconsin |
07/2008 - Present Associate Director, Biosafety Level Three Laboratories, Medical College of Wisconsin |
07/2008 - 08/2009 Member, Joint Safety Committee, Medical College of Wisconsin |
07/2008 - 07/2011 Member, Course Evaluation Committee, Graduate School for Biomedical Sciences, Medical College of Wisconsin |
08/2008 - Present Member, Executive Evaluation Committee, Graduate School for Biomedical Sciences Interdisciplinary Program, Medical College of Wisconsin |
12/2008 Member, Advancing a Healthier Wisconsin Initiative Grant Scientific Peer Review Panel, Medical College of Wisconsin |
05/2009 - Present Member, Ad Hoc Compliance Task Force on Tissues and Other Biospecimens, Medical College of Wisconsin |
08/2009 - Present Chair, Joint Safety Committee, Medical College of Wisconsin |
02/2010 - Present Member, Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Disease Faculty Recruitment Committee, Medical College of Wisconsin |
08/2010 - Present Member, Medical Scientist Training Program Mentoring Committee, Medical College of Wisconsin |
08/2010 - Present Member, Graduate Studies Council, MCW |
08/2011 - Present Member, Awards Committee, Graduate School for Biomedical Sciences, MCW |
MCW TEACHING ACTIVITIES: |
Medical Student Education |
08/2001 - 12/2001 M2 Lecturer-Microbiology Section-1 lecture (2 total contact hours) |
08/2002 - 12/2002 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2002 - 12/2002 M2 Lecturer-Microbiology Section-3 lectures (4 total contact hours) |
08/2003 - 12/2003 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2003 - 12/2003 M2 Lecturer-Microbiology Section-5 lectures (6 total contact hours) |
08/2004 - 12/2004 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2004 - 12/2004 M2 Lecturer-Microbiology Section-6 lectures (7 total contact hours) |
08/2005 - 12/2005 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2005 - 12/2005 M2 Lecturer-Microbiology Section-6 lectures (7 total contact hours) |
08/2006 - 12/2006 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2006 - 12/2006 M2 Lecturer-Microbiology Section-6 lectures (7 total contact hours) |
08/2007 - 12/2007 M2 Lecturer-Microbiology Section-6 lectures (7 total contact hours) |
08/2007 - 12/2007 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2008 - 12/2008 M2 Lecturer-Microbiology Section-6 lectures (7 total contact hours) |
08/2008 - 12/2008 M2 Microbiology Lab Instructor-19 sessions (40 total contact hours) |
08/2009 - 12/2009 M2 Lecturer-Microbiology Section-5 lectures (6 total contact hours) |
08/2009 - 12/2009 M2 Small Group Discussion Facilitator (4 total contact hours) |
01/2010 - 06/2010 Physician-Scientist Pathway Small Group Facilitator (18 total contact hours) |
08/2010 - 12/2010 M2 Lecturer-Microbiology Section-5 lectures (6 total contact hours) |
08/2010 - 12/2010 M2 Small Group Discussion Facilitator (4 total contact hours) |
09/2010 - 05/2011 Physician-Scientist Pathway Small Group Facilitator (13 total contact hours) |
Graduate Student Education |
08/2001 - 12/2001 Lecturer-05236 Cellular Microbiology-1 lecture (2.5 total contact hours) |
11/2002 - 05/2003 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (2.5 total contact hours) |
08/2003 - 12/2003 Lecturer-05236 Cellular Microbiology-4 lectures (7 total contact hours) |
11/2003 - 05/2004 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (2.5 total contact hours) |
11/2004 - 05/2005 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (2.5 total contact hours) |
01/2005 - 05/2005 Lecturer-16252 Class and Mol Genetics-1 lecture (2.5 total contact hours) |
01/2005 - 05/2005 Lecturer-05236 Cellular Microbiology-4 lectures (7 total contact hours) |
11/2005 - 05/2006 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (2.5 total contact hours) |
08/2006 - 12/2006 Co-Course Director, 05300 Microbiology and Molecular Genetics Seminar (30 total contact hours) |
11/2006 - 05/2007 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (2.5 total contact hours) |
01/2007 - 05/2007 Lecturer-05236 Cellular Microbiology-4 lectures (7 total contact hours) |
08/2007 - 12/2007 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (3.0 total contact hours) |
08/2007 - 12/2007 Co-Course Director, 05300 Microbiology and Molecular Genetics Seminar (22 total contact hours) |
08/2008 - 12/2008 Co-Course Director, 05300 Microbiology and Molecular Genetics Seminar (30 total contact hours) |
08/2008 - 12/2008 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (3.0 total contact hours) |
01/2009 - 05/2009 Lecturer-05236 Cellular Microbiology-4 lectures (7 total contact hours) |
08/2009 - 12/2009 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (3.0 total contact hours) |
08/2009 - 12/2009 Co-Course Director, 05300 Microbiology and Molecular Genetics Seminar (45 total contact hours) |
09/2009 - 11/2009 Course Director, 05260 Mucosal Pathogenesis-3 lectures (4.5 total contact hours) |
09/2009 - 11/2009 Course Director, 05260 Mucosal Pathogenesis-2 lectures (3.0 total contact hours) |
11/2009 - 12/2009 Lecturer-05261 Mucosal Toxins-1 lecture (1.5 total contact hours) |
08/2010 - 12/2010 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (3.0 total contact hours) |
08/2010 - 12/2010 Co-Course Director, 05300 Microbiology and Molecular Genetics Seminar (15 total contact hours) |
01/2011 - 05/2011 Lecturer-05236 Cellular Microbiology-4 lectures (7 total contact hours) |
08/2011 - 12/2011 Lecturer-05242 Tech. in Mol and Cell Biol-1 lecture (3.0 total contact hours) |
08/2011 - 12/2011 Co-Course Director, 05300 Microbiology and Molecular Genetics Seminar (45 total contact hours) |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Orser, C.S., C. C. Lang, L. Xun, T. C. Zahrt, and B.J. Schneider. Cloning, sequence analysis, and expression of the Flavobacterium pentacholorophenol-4-monooxygenase gene in Escherichia coli, J. Bacteriol. 175: 411-416. 1993. PMID: 7678243 |
2. Zahrt, Tom C., Guido C. Mora, and Stanley Maloy. Inactivation of mismatch repair overcomes the barrier to transduction between Salmonella typhimurium and Salmonella typhi, J. Bacteriol. 176: 1527-1529. 1994. PMID: 8113197 |
3. Zahrt, Thomas C., and Stanley Maloy. Barriers to recombination between closely related bacteria: MutS and RecBCD inhibit recombination between Salmonella typhimurium and Salmonella typhi, Proc. Natl. Acad. Sci. USA. 94: 9786-9791. 1997. PMID: 9275203 |
4. Zahrt, Thomas C., Nancy Buchmeier, and Stanley Maloy. Effect of mutS and recD mutations on Salmonella virulence, Infect. Immunol. 67: 6168-6172. 1999. PMID: 10531283 |
5. Maloy, Stanley, and Thomas Zahrt. Surrogate genetics: The use of bacterial hybrids as a genetic tool, Methods. 20:73-79. 2000. PMID: 10610806 |
6. Zahrt, Thomas C., and Vojo Deretic. An essential two-component signal transduction system in Mycobacterium tuberculosis, J. Bacteriol. 182:3832-3838. 2000. PMID: 10851001 |
7. Zahrt, Thomas C., Jian Song, Jessica Siple and Vojo Deretic. Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG, Mol. Microbiol. 39:1174-1185. 2001. PMID: 11251835 |
8. Master, S., Zahrt, T.C., Song, J. and V. Deretic. Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages, J. Bacteriol. 183:4033-1039. 2001. PMID: 11395468 |
9. Springer, B., Master, S., Sander, S., Zahrt, T., McFalone, M., Song, J., Papavinasaundaram, K. G., Colston, M. J., Boettger, E. and V. Deretic. Silencing of oxidative stress response in Mycobacterium tuberculosis: Expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation, Infect. Immunol. 69:5967-5973. 2001. PMID: 11553532 |
10. Zahrt, T. C. and V. Deretic. Mycobacterium tuberculosis two-component system required for persistent infections, Proc. Natl. Acad. Sci. USA. 98:12706-12711. 2001. PMID: 11675502 |
11. Zahrt, T. C. and V. Deretic. Reactive Nitrogen and Oxygen Intermediates and Bacterial Defenses: Unusual Adaptations in Mycobacterium tuberculosis, Antioxid Redox Signal. 4: 141-158. 2002. PMID: 11970850 |
12. Zahrt, T. C. Molecular mechanisms regulating persistent Mycobacterium tuberculosis infection, Microbes Infect. 5: 159-167. 2003. PMID: 12650744 |
13. Zahrt, T.C., Wozniak, C., Jones, D., and A. Trevett, Functional analysis of the Mycobacterium tuberculosis MprA-MprB two-component signal transduction system. Infect. Immun. 71: 6962-6970. 2003. PMID: 14638758 |
14. Hessner, Martin J., Singh, Vineet K., Khan, Shehnaz, Tschannen, Michael R., Wang, Xujing, and Thomas C. Zahrt, Utilization of Labeled Tracking Oligonucleotide for Visualization and Quality Control of Spotted 70-mer Arrays. BMC Genomics. 5: 12 (On-line). 2004. PMID: 15018646 |
15. Maier, Tamara M., Trevett, Andrea, Casey, Monika, Nano, Francis, Frank, Dara M., Thomas C. Zahrt, Construction of a Highly Efficient Francisella tularensis Shuttle Plasmid. Appl. Environ. Microbiol. 70: 7511-7519. 2004. PMID: 15574954 |
16. He, Hongjun and Thomas C. Zahrt, Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. J. Bacteriol. 187:202-212. 2005. PMID: 15601704 |
17. He, Hongjun, Hovey, Raymond, Kane, Jason, Singh, Vineet and Thomas C. Zahrt, MprAB is a stress responsive two-component system that directly regulates expression of SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 188:2134-2143. 2006. PMID: 16513743 |
18. Maier, TM, R. Pechous, M. Casey, T. Zahrt, and Dara W. Frank, In vivo-Himar1¬-based transposon mutagenesis of Francisella tularensis. Appl. Environ. Microbiol. 72: 1878-1885. 2006. PMID: 16517634 |
19. Pechous, R., J. Celli, S. Hayes, R. Penoske, D. Frank and Thomas C. Zahrt, Construction and characterization of a purine auxotroph in Francisella tularensis LVS. Infect. Immun. 74: 4452-4461. 2006. PMID: 16861631 |
20. Frank, DW and Thomas C. Zahrt, Genetics and genetic manipulation in Francisella tularensis. Ann. N.Y. Acad. Sci. 1105:67-97. 2007. PMID: 17395725 |
21. Jiaxin Li, Cheryl Ryder, Manas Mandal, Farzana Ahmed, Parastoo Azadi, D. Scott Snyder, Roger R. Pechous, Thomas Zahrt, and Thomas J. Inzana. Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS. Microbiology. 153: 3141-3153. 2007. PMID: 17768257 |
22. Maier, Tamara M., Casey, Monika S., Becker, Rachel H., Dorsey, Caleb W., Glass, Elizabeth M., Maltsev, Natalia, Zahrt, Thomas C. and Dara W. Frank. Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages. Infect. Immun. 75:5376-5389. 2007. PMID: 1768257 |
23. Pechous, Roger P., McCarthy, Travis M., Mohapatra, Nhrusing, Soni, Shilpa, Frank, Dara W., Gunn, John S., and Thomas C. Zahrt. A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. PLoS ONE. Jun 25;3(6):e2487. 2008. PMID: 18575611 |
24. Pechous, RD,McCarthy TR, and Thomas C. Zahrt. Working towards the future: Insights into Francisella tularensis pathogenesis and vaccine development. Microbiol. Mol. Biol. Rev. 73:684-711. 2009. PMID: 19946137 |
25. White MJ., He H, Penoske RM, Twining SS, and Thomas C. Zahrt. PepD participates in the Mycobacterial stress response mediated by MprAB and SigE. J. Bacteriol. 192:1498-1510. 2010. PMID: 20061478 |
26. Apicella MA, Post DMB, Fowler CA, Jones BD, Rasmussen JA, Hunt JR, Imagawa S, Choudhury B, Inzana TJ, Maier TM, Frank DW, Zahrt TC, Jennings MP, McLendon MK, and Gibson BW. Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis, PLoS One. 5(7):e11060. 2010. PMID: 20625403 |
27. White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC. The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein, PLoS One. 6(3):e18175. 2011. PMID: 21445360 |
28. He H, Bretl DJ, Penoske RM, Anderson DM, Zahrt TC. Components of the Rv0081-Rv0088 locus encoding a predicted formate hydrogenlyase complex are co-regulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis, J. Bacteriol: Epub ahead of print. 2011. PMID: 21821774 |
29. Bretl DJ, Demetriadou C, Zahrt TC. Adaptation to environmental stimuli within the host: two-component signal transduction systems of Mycobacterium tuberculosis. Microbiol Mol Biol Rev. 2011 Dec;75(4):566-82. PMCID: PMC3232741 |
30. Bretl DJ, He H, Demetriadou C, White MJ, Penoske RM, Salzman NH, Zahrt TC. MprA and DosR coregulate a Mycobacterium tuberculosis virulence operon encoding Rv1813c and Rv1812c. Infect Immun. 2012 Sep;80(9):3018-33. PMCID: PMC3418728 |
31. Celli J, Zahrt TC. Mechanisms of Francisella tularensis intracellular pathogenesis. Cold Spring Harb Perspect Med. 2013 Apr 01;3(4):a010314. PMCID: PMC3683997 |
32. Bretl DJ, Bigley TM, Terhune SS, Zahrt TC. The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. J Bacteriol. 2014 Jan;196(2):391-406. PMCID: PMC3911260 |
33. Armstrong RM, Adams KL, Zilisch JE, Bretl DJ, Sato H, Anderson DM, Zahrt TC. Rv2744c is a PspA ortholog that regulates lipid droplet homeostasis and non-replicating persistence in Mycobacterium tuberculosis, J. Bacteriol., 2016. 198(11):1645-1661. PMID: 27002134 |
34. Armstrong RM, Carter CC, Atkinson SN, Terhune SS, Zahrt TC. Association of Mycobacterium proteins with lipid droplets, J. Bacteriol., 2018. 200(16):e00240-18. PMID: 29760207 |
Books, Chapters, and Reviews |
1. Armstrong RM, Zahrt TC. Mycobacterial Infections and Lipid Droplets - Host and Pathogen Stealing, Sharing, and Storing Fat, 2019. In Tuberculosis Host-Pathogen Interactions. Invited Book Chapter for Springer Press. |
