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CURRICULUM VITAE

Tyce J. Kearl MD, PhD
Instructor
Department of Medicine
Division of Hematology and Oncology - Medicine

OFFICE ADDRESS:
Froedtert and Medical College Pavilion
9200 W Wisconsin Ave
Milwaukee, WI 53226

EDUCATION:
08/2000 - 05/2006 BA, Utah State University, Logan, UT
06/2006 - 05/2014 MD (2014), PhD (2012), Medical College of Wisconsin, Milwaukee, WI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
06/2014 - 06/2017 Resident, Department of Pediatrics, University of Wisconsin, Madison, WI
07/2017 - 06/2020 Fellow, Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
08/2020 - Present Instructor, Department of Medicine, Divisions of Hematology, Oncology, and Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI

RESEARCH ADMINISTRATIVE APPOINTMENTS:
08/2020 - Present Assistant Director, BMT and Cell Therapy Laboratory, Dept. of Medicine, Medical College of Wisconsin, Milwaukee, WI
02/2021 - Present Co-Director, Cell Therapy and Immune Monitoring shared resource laboratory, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI

HOSPITAL STAFF PRIVILEGES:
08/2020 - Present Children's Hospital of Wisconsin, 8915 W Connell Ct., Milwaukee, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
General Pediatrics
10/18/2017
None
Pediatric Hematology/Oncology
04/07/2021
None
 
Licensure
Number Issue DateExpiration
Wisconsin License
65649-20
09/2015
10/31/2021
 

AWARDS AND HONORS:
06/2005 - 08/2005 American Heart Association Summer Undergraduate Research Fellow
08/2005 - 05/2006 Research Fellow to the Vice Provost for Undergraduate Studies and Research, Utah State University
08/2005 - 05/2006 Eccles Undergraduate Research Fellow, College of Science, Utah State University
05/2014 Armand J. Quick Award for Outstanding Senior Medical Student in Biochemistry, Medical College of Wisconsin
10/2018 - 08/2020 Ruth L. Kirschstein National Service Award, NIH T32 HL007209-39, Blood Research Institute, Versiti, Milwaukee, WI
12/07/2021 ASH Abstract Achievement Award, American Society of Hematology

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
06/2014 - 06/2017 American Academy of Pediatrics
07/2017 - Present American Society of Hematology
07/2017 - Present American Society of Pediatric Hematology and Oncology
08/2020 - Present Society for the Immunotherapy of Cancer

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
03/19/2021 - Present Cancer Immunity and Immunotherapy (specialty section of Frontiers in Immunology and Frontiers in Oncology)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Epigenetic Regulation of the Anti-Tumor Efficacy of Chimeric Antigen Receptor (CAR) T cell Therapy
Source:
Medical College of Wisconsin Cancer Center
Role:
Co-PI
PI:
Tyce Kearl, MD, PhD; Weiguo Cui, MD, PhD
Dates:
07/01/2021 - 06/30/2022
Direct Funds:
$14,427
 
Title:
A patient-specific humanized murine model for oral cancer: Combining autologous hematopoietic stem cells and peripheral blood mononuclear cells in NSG-SGM3 vs MHC class I/II-deficient mice
Source:
Medical College of Wisconsin Center for Immunology
Role:
Co-I
PI:
Joseph Zenga, MD
Dates:
08/01/2021 - 06/30/2022
Direct Funds:
$20,000
 
Title:
Single-cell proteomics to characterize cancer immune checkpoint inhibitor toxicity
Source:
Medical College of Wisconsin Center for Immunology
Role:
Co-PI
PI:
Tyce Kearl, MD, PhD; Jonathan Thompson, MD
Dates:
08/01/2021 - 06/30/2022
Direct Funds:
$30,000
 
Prior
Non-Peer Review
Title:
Rebecca Slye Endowment Grant
Source:
Rebecca Slye Endowment, Medical College of Wisconsin
Role:
PI
Dates:
2009 - 2010
Direct Funds:
$10,000
 

COMMITTEE SERVICE:
Medical College of Wisconsin
07/2019 - 06/2020 member, Fellowship Program Evaluation Committee, Division of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, Medical College of Wisconsin
03/24/2021 - Present member, Role Clarity Workgroup, Division of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, Medical College of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
08/2008 - 12/2010 Small group tutor, M1 Developmental Biology
08/2010 - 12/2011 Small group tutor, M1 Human Physiology
05/2018 - Present Small group facilitator, M1 Immunology
 
Graduate Student Education
05/06/2021 - Present Immunotherapy lecture; Integrated Microbiology and Immunology course
 

EXTRAMURAL TEACHING:
Community/Lay Public
09/2004 - 12/2004 Utah State University, Supplemental Instructor, General Biology I
09/2005 - 12/2005 Utah State University, Teaching fellow, MCAT prep course
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Thakar MS, Kearl TJ, Malarkannan S. 2019. Controlling Cytokine Release Syndrome to harness the full potential of CAR-based cellular therapy. Frontiers Onc. 9:1529.
2. Kearl TJ, Jing W, Gershan JA, Johnson BD. 2013. Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma. J Immunol. 190(11):5620-8.
3. Larson MC, Woodliff JE, Hillery CA, Kearl TJ, Zhao M. 2012. Characterization of microparticle surface phosphatidylethanolamine using duramycin. Biochim Biophys Acta - Molecular and Cell Biology of Lipids. 1821(12):1501-7.
4. Dice MS, Kearl T, Ruben PC. 2006. Methods for studying voltage-gated sodium channels in heterologous expression systems. Methods Mol. Med. 129:163-85.
 
Abstracts
1. Mohrdieck N, Bates P, Rinella S, King C, Tippins K, Johnson B, Kearl T, Capitini C. 2021. An immune co-stimulatory vaccine, with adoptive transfer of natural killer cells and immune inhibition blockade, after allogeneic bone marrow transplant, delays and reduces neuroblastoma tumor growth. Pediatric Cancer Symposium - Exploring Immunotherapy in Peadiatric Cancers, Milwaukee, WI.
2. Kearl TJ, Mei A, Brown R, Johnson B, Schneider D, Dropulic B, Hari P, Shah NN, Malarkannan S. 2020. Single-cell RNA sequencing identifies expression patterns associated with clinical response to dual-targeted CAR-T cell therapy. American Society of Hematology Annual Meeting.
3. Bourgeois S, Kearl TJ, Burke MJ, McCormick ME. 2020. Case Report: Pediatric Follicular Lymphoma of the parotid gland. Society for Ear, Nose and Throat Advancement in Children 2020 Virtual Meeting.
4. Kearl TJ, Patel N, Casey K, Bashir M, Iskandar B, Salamat MS, Bradley K, Puccetti D. 2015. Multifocal glioblastoma: a pediatric case and literature review. Society for Neuro-Oncology 2015 Annual Meeting, San Antonio, TX.
5. Kearl TJ, Johnson BD. 2011. Programmed Death Receptor-1 as a Marker of Tumor-Reactive Cells in a Murine Model of Multiple Myeloma. Cancer Immunology and Immunotherapy: Building on Success, NCI, Bethesda, MD.
6. Kearl TJ, Johnson BD. 2011. Macrophage Migration Inhibitory Factor is Linked to Production of a Membrane-Bound Immunosuppressive Factor in a Murine Neuroblastoma Model. 27th Annual National MD/PhD Student Conference, Keystone, CO.
7. Kearl TJ, Johnson BD. 2009. Indoleamine 2,3-dioxygenase Expression by Murine T Cells Following In Vitro Exposure to Tumor Culture Supernatant. International Society for the Biological Therapy of Cancer 24th Annual Meeting, National Harbor, MD.
8. Kearl TJ, Ruben PC. 2006. Modulation of Slow Inactivation via PKA-dependent phosphorylation in Human Cardiac Voltage-gated Sodium Channels. Biophysical Society 50th Annual Meeting, Salt Lake City, UT.
9. Kearl TJ, Ruben PC. 2005. Differential Modulation of Fast- and Slow-Inactivation in Two Cardiac Na(V) Channel Isoforms by an Inactivation Inhibitor. National Conference on Undergraduate Research, Lexington, VA.
10. Kearl TJ, Ruben PC, Mevissen M. 2004. Differential Effects of SDZ 211-939 on Human and Bovine Voltage-gated Sodium Channel Inactivation may be due to difference in the DII-DIII Linkers. AAAS Pacific Division 85th Annual Meeting, Logan, UT.