CURRICULUM VITAE
Yaqiang Wang PhD, MS
Yaqiang Wang PhD, MS
Assistant Professor
Department of Biophysics
Department of Biophysics
OFFICE ADDRESS: |
8701 Watertown Plank Road |
Milwaukee, WI 53226 |
Phone: +1 (414) 9554033 |
Email: yawang@mcw.edu |
EDUCATION: |
2000 - 2004 B.S., Huazhong University of Science and Technology, Wuhan, China |
2004 - 2007 M.S., Chinese Academy of Sciences, Wuhan, China |
2007 - 2012 Ph.D., University of North Carolina at Chapel Hill, Chapel Hill, NC |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2012 - 2021 Postdoctoral Fellow, University of California Los Angeles, Los Angeles, CA |
2021 - 2025 Principal Scientist, Arrakis Therapeutics, Waltham, MA |
FACULTY APPOINTMENTS: |
2025 - Present Assistant Professor, Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226 |
2025 - Present Assistant Professor, Obstetrics & Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226 |
CENTER/INSTITUTE AFFILIATIONS: |
2025 - Present Member, Cancer Center |
2026 - Present Member, Cardiovascular Research Center |
AWARDS AND HONORS: |
2026 Career Development Award, American Heart Association |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2018 - Present RNA Society (Member) |
2025 - Present American Crystallographic Association (Member) |
2025 - Present American Heart Association (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Ad-Hoc Reviewer |
2020 - Present Advanced Drug Delivery Reviews |
2024 - Present Magnetic Resonance Letters |
2025 - Present Smart Medicine |
2025 - Present Journal of Chemical Information and Modeling |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
NMR Spectroscopy in RNA Drug Discovery, Bruker Webinar, Online, 01/30/2024 |
FBDD against RNA Targets, Drug Discovery chemistry, San Diego, 04/03/2024 |
Structure-Based Approach to Screen and Characterize RNA-Targeted Small Molecules, Discovery on Target, Boston, 10/01/2024 |
Isotopic Labeling Strategies for RNA-Targeted Drug Discovery, ISOTOPE DAYS, Online, 09/18/2025 |
NMR Spectroscopy in RNA Drug Discovery, RNA-Targeted Drug Discovery & Development Summit 2025, Boston, 12/02/2025 |
Local |
Structural Biology of Noncoding RNAs in Cancer and Rare Diseases, Pancreas Club, Medical College of Wisconsin, Milwaukee, 03/12/2026 |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Postdoctoral Researchers |
2025 - Present Riley Petersen, University of Wisconsin at Madison, PhD 2025 |
2026 - Present Paul Kremer, University of Georgia, PhD 2024 |
COMMUNITY SERVICE ACTIVITIES: |
2022 - Present RNA Society Award Committee |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Gao H, Xiang Y, Sun N, Zhu H, Wang Y, Liu M, Ma Y, Lei H. Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy. Neurochem Int. 2007 Jan;50(2):386-94. |
2. Li CX, Wang Y, Gao H, Pan WJ, Xiang Y, Huang M, Lei H. Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy. Neurochem Res. 2008 Nov;33(11):2342-9. |
3. Li C, Wang Y, Pielak GJ. Translational and rotational diffusion of a small globular protein under crowded conditions. J Phys Chem B. 2009 Oct 08;113(40):13390-2. PMCID: PMC2774775 |
4. Pielak G, Wang Y, Conggang L. Protein Diffusion and Macromolecular Crowding. Biophys J. 2010;98(3):4a. |
5. Li C, Wang GF, Wang Y, Creager-Allen R, Lutz EA, Scronce H, Slade KM, Ruf RA, Mehl RA, Pielak GJ. Protein (19)F NMR in Escherichia coli. J Am Chem Soc. 2010 Jan 13;132(1):321-7. doi: 10.1021/ja907966n. PMID: 20050707; PMCID: PMC2815348. |
6. Wang Y, Li C, Pielak GJ. Effects of proteins on protein diffusion. J Am Chem Soc. 2010 Jul 14;132(27):9392-7. PMCID: PMC2898919 |
7. Miklos AC, Sarkar M, Wang Y, Pielak GJ. Protein crowding tunes protein stability. J Am Chem Soc. 2011 May 11;133(18):7116-20. |
8. Schlesinger AP, Wang Y, Tadeo X, Millet O, Pielak GJ. Macromolecular crowding fails to fold a globular protein in cells. J Am Chem Soc. 2011 Jun 01;133(21):8082-5. PMCID: PMC3102155 |
9. Sarkar M, Montheith WB, Wang Y, Pielak GJ. Protein Stability and Macromolecular Crowding. Biohysic J. 2012 Jan; 102(3):55A. |
10. Wang Y, Sarkar M, Smith AE, Krois AS, Pielak GJ. Macromolecular crowding and protein stability. J Am Chem Soc. 2012 Oct 10;134(40):16614-8. |
11. Wang Y, Benton LA, Singh V, Pielak GJ. Disordered Protein Diffusion under Crowded Conditions. J Phys Chem Lett. 2012 Sep 20;3(18):2703-2706. PMCID: PMC3505085 |
12. Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO. Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end. J Biol Chem. 2013 Dec 20;288(51):36385-97. PMCID: PMC3868752 |
13. Wang Y, Yesselman JD, Zhang Q, Kang M, Feigon J. Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5125-34. PMCID: PMC5024593 |
14. Chan H, Wang Y, Feigon J. Progress in Human and Tetrahymena Telomerase Structure Determination. Annu Rev Biophys. 2017 May 22;46:199-225. PMCID: PMC5508521 |
15. Wang Y, Feigon J. Structural biology of telomerase and its interaction at telomeres. Curr Opin Struct Biol. 2017 Dec;47:77-87. PMCID: PMC5564310 |
16. Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, Feigon J. Structure of Telomerase with Telomeric DNA. Cell. 2018 May 17;173(5):1179-1190.e13. PMCID: PMC5995583 |
17. Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J. Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE. Nat Chem Biol. 2019 Feb;15(2):132-140. PMCID: PMC6339579 |
18. Wang Y, Sušac L, Feigon J. Structural Biology of Telomerase. Cold Spring Harb Perspect Biol. 2019 Dec 02;11(12). PMCID: PMC6886448 |
19. Wang Y, Gallagher-Jones M, Sušac L, Song H, Feigon J. A structurally conserved human and <i>Tetrahymena</i> telomerase catalytic core. Proc Natl Acad Sci U S A. 2020 Dec 08;117(49):31078-31087. PMCID: PMC7733840 |
20. Lu X, Li M, Arce FA, Ling J, Setiawan N, Wang Y, Shi X, Campbell HR, Nethercott MJ, Xu W, Munson EJ, Marsac PJ, Su Y. Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy. Mol Pharm. 2021 Dec 06;18(12):4310-4321. |
21. He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J. Structures of telomerase at several steps of telomere repeat synthesis. Nature. 2021 May;593(7859):454-459. PMCID: PMC8857963 |
22. Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J. Structure of active human telomerase with telomere shelterin protein TPP1. Nature. 2022 Apr;604(7906):578-583. PMCID: PMC9912816 |
23. He Y, Song H, Chan H, Liu B, Wang Y, Sušac L, Zhou ZH, Feigon J. Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. Nature. 2022 Aug;608(7924):813-818. PMCID: PMC9728385 |
24. Wang Y, He Y, Wang Y, Yang Y, Singh M, Eichhorn CD, Cheng X, Jiang YX, Zhou ZH, Feigon J. Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. J Mol Biol. 2023 Jun 01;435(11):168044. PMCID: PMC10988774 |
25. Yang Y, Murrali MG, Galvan S, Wang Y, Stephen C, Ajjampore N, Wang X, Feigon J. HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation. Nat Commun. 2026 Jan 15;17(1):1570. PMCID: PMC12901311 |
26. Petersen RJ, Wang Y. NMR-Based Fragment Screening for RNA-Targeted Drug Discovery. Molecules. 2026 Mar 10;31(6). PMCID: PMC13029659 |
27. Li C, Wang GF, Wang Y, Creager-Allen R, Lutz EA, Scronce H, Slade KM, Ruf RA, Mehl RA, Pielak GJ. Protein (19)F NMR in Escherichia coli. J Am Chem Soc. 2010 Jan 13;132(1):321-7. PMCID: PMC2815348 |
28. Lu XJ, Wang Y. Structural Pockets and Interacting RNA-Associated Ligands (SPIRAL): A DSSR-enabled Meta-Analysis of RNA-Small Molecule Recognition. bioRxiv. 2026 Jun 23. PMCID: PMC13228370 |
