CURRICULUM VITAE
Yiliang Chen PhD
Yiliang Chen PhD
Assistant Professor
Department of Medicine
Division of Endocrinology
Department of Medicine
Division of Endocrinology
OFFICE ADDRESS: |
The Blood Research Institute |
Versiti Inc |
Milwaukee, WI 53226 |
EDUCATION: |
09/1997 - 07/2001 BS, Fudan University, Shanghai, China |
08/2002 - 07/2004 MS, National University of Singapore, Singapore, Singapore |
08/2004 - 09/2009 PhD, University of Toledo, Toledo, OH |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
10/2009 - 08/2011 Postdoctoral Fellow, Department of Pharmacology, University of Toledo, Toledo, OH |
09/2011 - 05/2015 Postdoctoral Fellow, Vascular Pathobiology, Blood Research Institute, WI |
06/2015 - 08/2020 Research Scientist I, Vascular Pathobiology, Blood Research Institute, WI |
MILITARY SERVICE: |
None |
FACULTY APPOINTMENTS: |
09/01/2020 - Present Assistant Investigator, Blood Research of Wisconsin, Versiti, Milwaukee, WI 53226 |
09/2020 - Present Assistant Professor, Department of Medicine, Division of Endocrinology & Molecular Medicine, The Medical College of Wisconsin, Milwaukee, WI |
01/2021 - Present Present Assistant Professor, Biochemistry, MCW, WI |
ADMINISTRATIVE APPOINTMENTS: |
None |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
None |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
None |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
None |
HOSPITAL STAFF PRIVILEGES: |
None |
AWARDS AND HONORS: |
09/2008 - Present Retiree's Scholarship Award Winner, University of Toledo |
05/2012 - Present ATVB 2012 Travel Award for Young Investigators |
01/2022 - Present Faculty Career Development Award, Medical College of Wisconsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2009 - 2010 American Society for Cell Biology |
2010 - 2011 American Society of Nephrology |
2011 - Present American Heart Association |
2016 - 2018 American Association for the Advancement of Science |
02/24/2021 - Present Chinese American Diabetes Association (Member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
02/04/2021 - Present Associate Editor, Frontiers in Cardiovascular Medicine-Lipidology |
Journal Review |
2016 - Present Blood, Experimental and Therapeutic Medicine, Marine Drugs, Cells, Molecules, Applied Sciences, International Journal of Molecular Sciences |
2020 - Present Molecular Aspects of Medicine |
Ad-Hoc Reviewer |
08/2012 - 12/2012 Scientist Development Grant, American Heart Association |
10/2021 - 04/2022 Advancing a Healthier Wisconsin Endowment, Collaborative Research for Improved Health Grant |
09/2022 - 10/2022 Advancing a Healthier Wisconsin Endowment, MCW-Led Seed Grant |
10/2022 - 11/2022 Medical College of Wisconsin Cancer Center, Pilot Grant |
02/2023 - Present American Heart Association, Career Development Grant |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
“Na/K-ATPase/CD36 signaling and atherosclerosis”,, Department of Medicine Annual Research Retreat, MKE, WI, 03/2015 |
“CD36 recruits NKA/Lyn complex to mediate pro-atherogenic phenotypes in macrophages”, ATVB meeting seminar, Cardiovascular Center, MCW, 04/20/2015 |
“Macrophage immunometabolism: the effects of oxLDL and the role of scavenger receptors”, ATVB meeting seminar, CVC, MCW, 06/26/2017 |
“Oxidized LDL alter immunometabolism via CD36”, ATVB meeting seminar, Cardiovascular Center, Medical College of Wisconsin, 10/23/2017 |
“CD36 couples macrophage fatty acid metabolism to oxidative stress and inflammation”,, ATVB meeting seminar, Cardiovascular Center, MCW, 09/24/2018 |
“CD36 in macrophage immunometabolism”, ATVB meeting seminar, Cardiovascular Center, MCW, 10/18/2018 |
“CD36 couples macrophage fatty acid metabolism to oxidative stress and inflammation”, ATVB meeting seminar, Cardiovascular Center, MCW, 06/24/2019 |
“CD36/NKA complex couples fatty acid metabolism to oxidative stress and inflammation”, Na/K-ATPase symposium, University of Toledo, 07/08/2019 |
“Na/K-ATPase, a negative regulator of LPS signaling in macrophages”,, ATVB meeting seminar, Cardiovascular Center, MCW, 08/10/2020 |
Yiliang chen, How does cellular metabolism determine macrophage activation, seminar, MCW-Biochemistry Department, 01/06/2021 |
“Regulation of Efferocytosis by Macrophage Mitochondria”, MCW Cardiovascular Winter Retreat, 12/08/2021 |
“Oxidized LDL Stimulates Efferocytosis through Mitochondrial Reactive Oxygen Species”, MCW Department of Medicine Annual Retreat, 03/05/2022 |
“Mitochondrial reactive oxygen species promote macrophage phagocytosis function”, ATVB meeting seminar, Cardiovascular Center, MCW, 05/23/2022 |
Yiliang Chen, ATVB meeting presentations, Cardiovascular Center, Medical College of Wisconsin, Milwaukee WI. 2014-present |
Regional |
“The signaling Na/K-ATPase and atherosclerosis”, seminar, University of Toledo, OH, 06/29/2015 |
“Oxidized LDL stimulates a metabolic switch via CD36 in macrophages”, Seminar, Milwaukee Area Mitochondriacs, WI, 01/08/2018 |
“CD36 couples macrophage fatty acid metabolism to oxidative stress and inflammation”, Annual Na/K-ATPase symposium, Marshall Universityv, WV, 07/08/2019 |
National |
“Macrophage in Atherosclerosis: Dual functions of CD36 linking metabolism to inflammation”, Seminar, Chinese American Diabetes Association, 03/03/2022 |
International |
“Oxidative Stress and Mitochondrial Dysfunction in Infections-Mitochondrial Reactive Oxygen Species, friends or foes?”, Section “Frontiers in Science: Atherosclerosis, Thrombosis and Vascular Biology”, American Heart Association Scientific Session, Chicago, IL, 11/04/2022 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Local |
Yiliang Chen, Na/K-ATPase/CD36 signaling and atherosclerosis, Department of Medicine Annual Research Retreat, Milwaukee, - 03/2015 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
01/2011 - 12/2015 Postdoctoral Advisory Committee |
09/01/2020 - Present faculty member, Graduate and Postdoc Seminar Series, Blood Research Institute |
07/2022 - Present Vascular Biology and Cell Therapy Program Committee, Present Transfusion Medicine, Blood Research Institute, Versiti |
08/2022 - Present Present Versiti Blood Research Institute (VBRI) Educational Committee, Blood Research institute, Versiti |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Salvado Yepez, Medical College of Wisconsin, 01/01/2017 - 12/31/2019 mentor, Kirschstein National Research Service Award Short-Term Institutional Research Training Grant (T35) program |
Demetra Korkos, MCW, 2019 - Present help her follow up the work by Moua, current project: “ERK5 and CD36 link oxidative stress to platelet dysfunctions” |
Jordan Bobek, MCW, 2022 - Present Mentor, Dissertation project “Impact of Aldehydes-Modified HDL on macrophage biology and cardiovascular disease”. |
Graduate Students |
PhD Students Advised |
MouaYang, Medical College of Wisconsin, 08/25/2012 - 07/28/2017 Regulation of Platelet CD36 by Redox Signaling, K99/R00 awarded by NIH-NHLBI after he completed postdoc at Harvard |
Postdoctoral Students |
Jue Zhang, Medical College of Wisconsin, 09/21/2020 - Present Academic Mentorship, Career Development Award and Peer-review publications |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
Emily Zhang, Blood Research Institute, Versiti, 06/01/2021 - 08/27/2021 Summer High School Student Internship |
Undergraduate Students |
Lailah Chadwick, 06/27/2022 - 08/04/2022 CTSI 500 Stars Program |
Postdoctoral Students |
Mirza Ahmar Beg, Blood Research Institute, Versiti, 09/20/2021 - Present |
Clinical/Research Fellows |
Michelle Roberts, PhD,, Medical College of Wisconsin,, 08/09/2022 - Present Postdoctoral Research Fellow, |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Ting Cai, Haojie Wang, Yiliang Chen, Lijun Liu, William T Gunning, Luis Eduardo M. Quintas, Zi-Jian Xie. "Regulation of Caveolin-1 Membrane Trafficking by the Na/K-ATPase" J. Cell. Biol. Vol 182, No. 6, 1153-69, 2008. |
2. Yiliang Chen, Ting Cai, Haojie Wang, Zhichuan Li, Elizabeth Loreaux, Jerry B. Lingrel, Zijian Xie. "Regulation of Intracellular Cholesterol Distribution by Na/K-ATPase" J. Biol. Chem. Vol 284, No. 22, 14881-90, 2009 |
3. Yiliang Chen, Xin Li, Qiqi Ye, Jiang Tian, Runming Jing, Zijian Xie. "Regulation of the α1 Na/K-ATPase Expression by Cholesterol" J. Biol. Chem. Vol 286, No. 17, 15517-24, 2011 |
4. Changxuan Liu, Yan Bai, Yiliang Chen, Yoann Sottjeau, Lijun Liu, Jerry B. Lingrel, Xiaomei Li, Christopher J. Cooper, Joseph I. Shapiro, Zijian Xie, Jian Tian. "Reduction of Na/K-ATPase Potentiates Marinobufagenin-Induced Cardiac Dysfunction and Myocyte Apoptosis" J. Biol. Chem. Vol 287, No. 12, 16390-8, 2012 |
5. David J. Kennedy, Yiliang Chen, Wenxin Huang, Jamie Viterna, Jiang Liu, Kristen Westfall, Jian Tian, David Bartlett, W. H. Wilson Tang, Zi-jian Xie, Joseph I. Shapiro and Roy L. Silverstein. "CD36 and Na/K ATPase-α1 Form a Pro-Inflammatory Signaling Loop in Kidney" Hypertension. Vol 61. 216-224, 2013 |
6. Alexandra C. Chadwick, Rebecca L. Holme, Yiliang Chen, Michael J. Thomas, Mary G. Sorci-Thomas, Roy L. Silverstein, Kirkwood A. Pritchard, Jr. and Daisy Sahoo. "Acrolein Impairs the Cholesterol Transport Functions of High Density Lipoproteins" PloS One, 2015, 10 (4): e0123138. |
7. Yiliang Chen, David J. Kennedy, Devi Prasadh Ramakrishnan, Moua Yang, Wenxin Huang, Zhichuan Li, Zijian Xie, Alexandra C. Chadwick, Daisy Sahoo, Roy L. Silverstein. "Oxidized LDL-bound CD36 recruits a Na+/K+-ATPase-Lyn complex in macrophages that promotes atherosclerosis" Science Signaling, 8 (393): ra91, 2015 |
8. Devi Prasadh Ramakrishnan, Rula A. Hajj-Ali, Yiliang Chen, Roy L. Silverstein. "Extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation" Arteriosclerosis, Thrombosis, and Vascular Biology, 36(3):534-544, 2016 |
9. Liuyi Dong, Ye Yuan, Cynthia Opansky, Yiliang Chen, Irene Aguilera-Barrantes, Shiyong Wu, Rong Yuan, Qi Cao, Yee Chung Cheng, Daisy Sahoo, Roy L. Silverstein, Bin Ren. "Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling" Oncotarget, 2017 |
10. Moua Yang, Brian C Cooley, Wei Li, Yiliang Chen, Jeannette Vasquez-Vivar, Na'il O Scoggins, Scott Cameron, Craig N Morrell, Roy L. Silverstein. "Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions" Blood, 129(21):2917-2927, 2017 |
11. Yiliang Chen, Wenxin Huang, Yang Moua, Xin Gang, Weiguo Cui, Zijian Xie, Roy L. Silverstein. "Cardiotonic steroids stimulate macrophage inflammatory responses through a pathway involving CD36, TLR4, and Na/K-ATPase" Arteriosclerosis Thrombosis, and Vascular Biology, 37(8): 1462-1469, 2017 |
12. Xiaoliang Wang, Liquan Cai, Jeffrey X. Xie, Xiaoyu Cui, Jue Zhang, Jiayan Wang, Yiliang Chen, Isabel Larre, Joseph I. Shapiro, Sandrine V. Pierre, Dianqing Wu, Guo-Zhang Zhu and Zijian Xie. "A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C. elegans". Science Advances. 2020 |
13. Rebecca L. Schill, Yiliang Chen, Darcy A. Knaack, Daniel J. Schill, Moua Yang, Roy L. Silverstein, and Daisy Sahoo. "Modification of HDL by Reactive Aldehydes Alters selective CardioProtective Functions of HDL in Macrophages". The FEBS Journal. Aug. 6. 2019 |
14. *Yiliang Chen, Moua Yang, Wenxin Huang, Wenjing Chen, Yiqiong Zhao, Marie L. Schulte, Peter Volberding, Zachary Gerbec, Michael T. Zimmermann, Atefeh Zeighami, Wendy Demos, Jue Zhang, Darcy Knaack, Brian C. Smith, Weiguo Cui, Subramaniam Malarkannan, Komal Sodhi, Joseph I. Shapiro, Zijian Xie, Daisy Sahoo, Roy L. Silverstein. "Mitochondrial metabolic reprogramming by CD36 signaling drives macrophage inflammatory responses". Circulation Research. 125(12):1087-1102. 2019. *Corresponding author. |
15. Fatimah Khalaf, Amal Mohamed, Yiliang Chen, Deepak Malhotra, Zijian Xie, Jiang Tian, Steven Haller, Kristen Westfall, WH Tang, and David Kennedy. "Epithelial and Endothelial Adhesion of Immune Cells is Enhanced by Cardiotonic Steroids Signaling through Na/K-ATPase alpha1". Journal of the American Heart Association. 9:e013933. 2020 |
16. Komal Sodhi, James Denvir, Jiang Liu, Juan R. Sanabria, Yiliang Chen, Roy Silverstein, Zi Jian Xie, Nader G. Abraham, Joseph I. Shapiro. "Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop". International Journal of Molecular Sciences. 2020 Aug 18;21(16). |
17. Jue Zhang, Xin Li, Hui Yu, Isabel Larre, Sandrine V. Pierre, Zijian Xie, *Yiliang Chen. "Isoform-specific regulation of Na/K-ATPase by cholesterol is dependent on Na/K-ATPase/caveolin-1/src complex". American Journal of Physiology. 2020. Dec 1;319(6):C1107-C1119. *Corresponding author. |
18. Gang Xin , Yao Chen , Paytsar Topchyan , Moujtaba Kasmani , Robert Burns , Peter Volberding , Alexandra Cohn , Yiliang Chen, Chien-Wei Lin , Ping-Chih Ho , Roy Silverstein. “Targeting PIM1 Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer”. Cancer Immunology Research, 2021. Feb 12. |
19. Flavio Palma, Bianca Ratti, Jeanne Danes, Andre de Abreu, Sueli Lautenschlager, Veronica Paviani, Sofia Zaichik, Yiliang Chen, Roy Silverstein, Dean Jones, Uppal Karan, Diego Coelho "AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism." Oncogene. 2021. Jul.21 |
20. Hou Y, Wang Q, Han B, Chen Y, Qiao X, Wang L. "CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys". Cell Death Dis. 2021 May 21;12(6):523. |
21. Wen Dai, Hayley Lund, Yiliang Chen, Jue Zhang, Kristen Osinski,
Stephanie Zellner Jones, Lisa Baumann Kreuziger, José A. López, Ivor J. Benjamin,Roy L. Silverstein, Ze Zheng "Hypertriglyceridemia during hospitalization independently associates with mortality in patients with COVID-19" Journal of Clinical Lipidology, 2021, 15(5):724 |
22. Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y. Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn. iScience. 2022 Sep 16;25(9):104963. PMCID: PMC9442361 |
23. Wenxin Huang, Renhao Li, Jue Zhang, Yiliang Chen, Devi P. Ramakrishnan, Roy L. Silverstein. “A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions” Translational Research, 2022, S1931 (22). |
24. Shreya Mukherji, Luca Brambilla, Kailey Stuart, Isabella Mayes, Laura Kutz, Yiliang Chen, Jeffrey McDermott, Steven Haller, Michael Romero, Manoocher Soleimani, Jiang Liu, Joseph Shapiro, V. Gustavo Blanco, Zijian Xie “Na/K-ATPase Signaling Tonically Inhibits Sodium Absorption in the Renal Proximal Tubule” FASEB Journal, 2023, 37 (4), e22835 |
25. Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z. Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19 Research and Practice in Thrombosis and Haemostasis. August 2023;7(6). |
26. Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y. Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL. Front Cardiovasc Med. 2023;10:1046495. PMCID: PMC10174328 |
27. Mukherji ST, Brambilla L, Stuart KB, Mayes I, Kutz LC, Chen Y, Barbosa LA, Elmadbouh I, McDermott JP, Haller ST, Romero MF, Soleimani M, Liu J, Shapiro JI, Blanco GV, Xie Z, Pierre SV. Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule. FASEB J. 2023 Apr;37(4):e22835. PMCID: PMC10028530 |
28. Zhang J, Dai W, Chen Y. Editorial: The Roles of Lipids in Immunometabolism: The Crosstalk Between Lipid Metabolisms and Inflammation. Front Cardiovasc Med. 2022;9:938535. PMCID: PMC9257247 |
29. Chen Y, Zhang J, Cui W, Silverstein RL. CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate. J Exp Med. 2022 Jun 06;219(6). PMCID: PMC9022290 |
Books, Chapters, and Reviews |
1. Yiliang Chen, Devi Prasadh, and Bin Ren. "Regulation of Angiogenesis by Phospholipid Lysophosphatidic Acid" Frontiers in Bioscience. Vol 18. 852-861, 2013 |
2. *Yiliang Chen, Jue Zhang, Weiguo Cui, and Roy L. Silverstein. “CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate” Journal of Experimental Medicine. In press. 2022 *Corresponding author. |
3. Yiliang Chen, Roy Silverstein. “Platelet metabolism meets thrombosis” Blood, 2018, 132(11):1089 |
4. Jue Zhang, and Wen Dai, *Yiliang Chen. “Editorial: The role of lipids in immunometabolism: The crosstalk between lipid metabolism and inflammation” Frontiers in Cardiovascular Medicine. Jun. 22, 2022 *Corresponding author. |
