CURRICULUM VITAE
Yunguang Sun MD, PhD
Yunguang Sun MD, PhD
Assistant Professor
Department of Pathology
Division of Administration
Department of Pathology
Division of Administration
OFFICE ADDRESS: |
Translational and Biomedical Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
Phone: 414-955-7587 |
Email: ysun@mcw.edu |
EDUCATION: |
09/1993 - 06/1998 M.D., Nanjing Medical University, Nanjing, Jiangsu |
09/1998 - 06/2003 Ph.D., Fudan University, Shanghai, China |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
08/2003 - 07/2008 Visiting Fellow, Clinical Endocrinology Branch, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 |
08/2008 - 05/2011 Research Fellow, Department of Radiation Oncology, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235 |
05/2011 - 10/2014 Research Associate, Department of Radiation Oncology, Thomas Jefferson University, 1020 Walnut Street, Philadelphia, PA 19107 |
11/2014 - 06/2015 Research Associate, Department of Cancer Biology, Thomas Jefferson University, 1020 Walnut Street, Philadelphia, PA 19107 |
MILITARY SERVICE: |
N/A |
FACULTY APPOINTMENTS: |
06/2015 - Present Assistant Professor, Department of Pathology, The Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226 |
ADMINISTRATIVE APPOINTMENTS: |
N/A |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
N/A |
HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: |
N/A |
RESEARCH ADMINISTRATIVE APPOINTMENTS: |
N/A |
HOSPITAL STAFF PRIVILEGES: |
N/A |
AWARDS AND HONORS: |
06/2008 NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) Fellow Scientific Retreat Travel Awards, NIH (National Institutes of Health) |
06/2010 VICTR (Vanderbilt Institute for Clinical and Translational Research) resource award, ID: VR1780, VR1376, VR967, supported by Vanderbilt CTSA grant UL1 RR024975 from NCRR/NIH (2010) |
11/2022 Best use of data 2022 Hack4NF event, the Children's Tumor Foundation |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
06/2009 - 06/2010 Sigma Xi |
01/2010 - 12/2011 Associate member (American Association of Cancer Research) |
06/2016 - Present MCW Cancer Center (member) |
05/2022 - Present Association of Biomolecular Resource Facilities (member) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
11/2018 - Present Journal of Veterinary Science and Research |
02/2019 - Present Scientific Reports |
Journal Review |
06/2010 - Present Journal of Oncology |
06/2010 - Present Cell Biology International |
2011 - Present International Journal of Biological Sciences |
2011 - Present Clinical Medicine Insights: Oncology |
08/2021 - Present Briefings in Bioinformatics |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
N/A |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
National |
L. Moretti, Y. Sun, L. Mitchell, B. Lu,, Terameprocol a Novel Survivin Inhibitor Leads to Radiosensitization of Non-Small Lung Cancer, Annual Meeting & Program Committee of the American Society for Radiation Oncology (ASTRO), Chicago IL, 11/01/2009 - 11/05/2009 |
L. Moretti, Y. Sun, B. Lu,, TG-AZ1, a Novel JAK2 Inhibitor Inhibits Survivin and Enhances Radiation Therapy in Non-Small Lung Cancer, American Thoracic International Conference, New Orleans, LA, 05/14/2010 - 05/19/2010 |
Y. Sun, Y. Zheng, C. Speris,B. Lu, Genetic profiling of lung cancer stem-like cells reveals IGF signaling pathway as a promising target for therapeutic resistance, Annual Meeting & Program Committee of the American Society for Radiation Oncology (ASTRO), San Diego, CA, 10/31/2010 - 11/04/2010 |
K. Nowak, Y. Sun, M. Werner‐Wasik, A. P. Dicker,B. Lu, PF02340166 Inhibits ALK Downstream Effectors And Increases Sensitivity To Radiation In Cells Harboring The EML4‐ALK Fusion, Annual Meeting & Program Committee of the American Society for Radiation Oncology (ASTRO), Boston, MA, 10/28/2012 - 11/01/2012 |
Lubna Naaz Chaudhary, Julie M Jorns, Yee Chung Cheng, Sailaja Kamaraju, John Burfeind, Mary Beth Gonyo, Amanda Kong, Caitlin Patten, Tina Yen, Chandler Cortina, Ebony Carson, Nedra Johnson, Carmen Bergom, Anjishnu Banerjee, Yu Wang, Yunguang Sun, Christopher R Chitambar, Hallgeir Rui, HER1-4 protein up-regulation following short-term neoadjuvant endocrine therapy in patients with hormone receptor-positive HER2-negative breast cancer, 2021 San Antonio Breast Cancer Symposium, San Antonio, TX, 12/07/2021 - 12/11/2021 |
Lubna N. Chaudhary, Inna Chervoneva, Amy R. Peck, Yunguang Sun, Misung Yi, John F. Langenheim, Julie M. Jorns, Sailaja Kamaraju, Yee Chung Cheng, John Burfeind, Christopher R. Chitambar, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Juan P. Palazzo, Marluce Bibbo, Terry Hyslop, Richard G. Pestell, Edith P. Mitchell, and Hallgeir Ru, High PD-L2 Protein Expression in Cancer Cells is an Independent Marker of Unfavorable
Prognosis in Luminal Breast Tumors, 2022 San Antonio Breast Cancer Symposium, San Antonio, TX, 12/06/2022 - 12/10/2022 |
International |
L. Moretti, Y. Sun, B. Lu, Targeting of STAT3 and survivin with TG101209 a novel JAK2 inhibitor enhances radiotherapy in lung cancer models, Annual Congress of European Respiratory Society (ERS), Barcelona, Spain, 09/18/2010 - 09/22/2010 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
12/02/2021 - Present permanent member, ACS-IRG Review panel, Cancer Research Training and Education (CRTE) office, Medical College of Wisconsin |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Medical Student Education |
05/27/2021 - Present Teach image analysis using QuPath for two medical students, Mathew Hargreaves and Rehaan Machhi |
09/22/2023 - Present mentor of Rehaan Machhi on Medical student research project |
Resident and Fellow Education |
10/28/2022 - Present Teaching image analysis using Qupath software |
Continuing Medical Education |
01/01/2021 - Present General education for MCW Tissue Bank - Biorepository & Tissue Analytics core users, such as digital pathology service provided |
Postdoctoral Fellow Education |
09/01/2016 - 06/30/2021 Lab techniques |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Mathew Hargreaves, Medical College of Wisconsin, 05/27/2021 - Present Mathew Hargreaves, manuscript in preparation for publication |
Rehaan Machhi, Medical College of Wisconsin, 01/08/2023 - Present, manuscript in preparation for publication |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Nicholas Giacalone (Grade II), Vanderbilt University, 01/2010 - 06/2010 Capacity (Research mentor). |
Stephen Matthew Schleicher (Grade IV), Vanderbilt University, 01/2010 - 06/2010 Capacity (Research mentor). |
Kamila Nowak, Thomas Jefferson University, 01/2012 - 06/2012 Capacity (Research mentor)., Published a research paper on Mol Cancer Ther in 2013 |
Chia-Lin Winchester, Thomas Jefferson University, 01/2012 - 06/2012 Capacity (Research mentor)., Published a research paper on Mol Cancer Ther in 2013 |
Kunal Dalal, Thomas Jefferson University, 01/2012 - 06/2012 Capacity (Research mentor). |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Zhou Z, Hu Y, Sun Y, Chen J. Protective effect of clonidine against toxicity of organophosphorus pesticides Journal of Occupational Health. 2001;43(6):346-350. |
2. Sun Y, Zhou Z, Hu Y, Chen J, Jin T. [The acute effects of dimethoate on the muscarinic-receptors of rat brains and the relationship between muscarinic-receptors and cholinesterase]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002 Aug;20(4):293-5. |
3. Sun YG, Zhou ZJ, Zhang XM, Gu XA, Jin TY. [Expression of M3 receptor gene in peripheral blood lymphocytes of workers exposed to dimethoate]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):3-6. |
4. Sun YG, Zhou ZJ, Zhang XM, Gu XA, Jin TY. [Muscarine receptor gene expression in brain and peripheral blood lymphocytes of rats pretreated with dimethoate for 28 days]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):7-10. |
5. Dai XF, Zhou ZJ, Gu XA, Sun YG, Zheng G, Zheng J. [Protective effect of memantine on N-methyl-D-aspartate receptor in dichlorvos-poisoned rat brain]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):11-4. |
6. Zhou Z, Dai X, Gu X, Sun Y, Zheng G, Zheng J. Memantine alleviates toxicity induced by dichlorvos in rats. J Occup Health. 2005 Mar;47(2):96-101. |
7. Kim Y, Sun Y, Chow C, Pommier YG, Simons SS Jr. Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):3-17. |
8. Sun Y, Tao YG, Kagan BL, He Y, Simons SS Jr. Modulation of transcription parameters in glucocorticoid receptor-mediated repression. Mol Cell Endocrinol. 2008 Nov 25;295(1-2):59-69. PMCID: PMC2662735 |
9. Sun Y, Giacalone NJ, Lu B. Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma. J Thorac Oncol. 2011 Jan;6(1):8-14. PMCID: PMC3010256 |
10. Niermann KJ, Moretti L, Giacalone NJ, Sun Y, Schleicher SM, Kopsombut P, Mitchell LR, Kim KW, Lu B. Enhanced radiosensitivity of androgen-resistant prostate cancer: AZD1152-mediated Aurora kinase B inhibition. Radiat Res. 2011 Apr;175(4):444-51. PMCID: PMC3133747 |
11. Sun Y, Moretti L, Giacalone NJ, Schleicher S, Speirs CK, Carbone DP, Lu B. Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models. J Thorac Oncol. 2011 Apr;6(4):699-706. PMCID: PMC3104103 |
12. Morrison R, Schleicher SM, Sun Y, Niermann KJ, Kim S, Spratt DE, Chung CH, Lu B. Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis. J Oncol. 2011;2011:941876. PMCID: PMC2958340 |
13. Li W, Li B, Giacalone NJ, Torossian A, Sun Y, Niu K, Lin-Tsai O, Lu B. BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro. J Thorac Oncol. 2011 Nov;6(11):1801-9. PMCID: PMC3196825 |
14. Sun Y, Zheng S, Torossian A, Speirs CK, Schleicher S, Giacalone NJ, Carbone DP, Zhao Z, Lu B. Role of insulin-like growth factor-1 signaling pathway in cisplatin-resistant lung cancer cells. Int J Radiat Oncol Biol Phys. 2012 Mar 01;82(3):e563-72. PMCID: PMC3271860 |
15. Li B, Torossian A, Sun Y, Du R, Dicker AP, Lu B. Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458, a novel selective c-Met inhibitor with radiosensitizing effects. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e525-31. |
16. Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. J Biol Chem. 2013 Jan 04;288(1):42-58. PMCID: PMC3537039 |
17. Sun Y, Nowak KA, Zaorsky NG, Winchester CL, Dalal K, Giacalone NJ, Liu N, Werner-Wasik M, Wasik MA, Dicker AP, Lu B. ALK inhibitor PF02341066 (crizotinib) increases sensitivity to radiation in non-small cell lung cancer expressing EML4-ALK. Mol Cancer Ther. 2013 May;12(5):696-704. PMCID: PMC3651772 |
18. Zaorsky NG, Sun Y, Wang Z, Palmer J, Fortina PM, Solomides C, Werner-Wasik M, Dicker AP, Axelrod R, Campling B, Evans N 3rd, Cowan S, Lu B. Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab. Cancer Biol Ther. 2013 Oct 01;14(10):883-7. PMCID: PMC3926884 |
19. Li B, Blanc JM, Sun Y, Yang L, Zaorsky NG, Giacalone NJ, Torossian A, Lu B. Assessment of M867, a selective caspase-3 inhibitor, in an orthotopic mouse model for non-small cell lung carcinoma. Am J Cancer Res. 2014;4(2):161-71. PMCID: PMC3960453 |
20. Liu N, Tao Z, Blanc JM, Zaorsky NG, Sun Y, Vuagniaux G, Dicker AP, Lu B. Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro. Am J Cancer Res. 2014;4(6):943-51. PMCID: PMC4266726 |
21. Sun Y, Myers CJ, Dicker AP, Lu B. A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect. PLoS One. 2014;9(2):e87492. PMCID: PMC3928108 |
22. Lakshmikuttyamma A, Sun Y, Lu B, Undieh AS, Shoyele SA. Stable and efficient transfection of siRNA for mutated KRAS silencing using novel hybrid nanoparticles. Mol Pharm. 2014 Dec 01;11(12):4415-24. |
23. Wang YA, Sun Y, Le Blanc JM, Solomides C, Zhan T, Lu B. Nitrilase 1 modulates lung tumor progression in vitro and in vivo. Oncotarget. 2016 Apr 19;7(16):21381-92. PMCID: PMC5008292 |
24. Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL. SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. Oncogene. 2017 Dec 14;36(50):6873-6883. PMCID: PMC5730474 |
25. Wang YA, Sun Y, Palmer J, Solomides C, Huang LC, Shyr Y, Dicker AP, Lu B. IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling. Mol Cancer Res. 2017 Jul;15(7):896-904. |
26. Gennaro VJ, Stanek TJ, Peck AR, Sun Y, Wang F, Qie S, Knudsen KE, Rui H, Butt T, Diehl JA, McMahon SB. Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. Proc Natl Acad Sci U S A. 2018 Oct 02;115(40):E9298-E9307. PMCID: PMC6176615 |
27. Tran TH, Utama FE, Sato T, Peck AR, Langenheim JF, Udhane SS, Sun Y, Liu C, Girondo MA, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Palazzo JP, Bibbo M, Auer PW, Flister MJ, Hyslop T, Mitchell EP, Chervoneva I, Rui H. Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling. Clin Cancer Res. 2018 Dec 15;24(24):6355-6366. |
28. Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C. Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3. Am J Physiol Heart Circ Physiol. 2019 Jun 01;316(6):H1267-H1280. PMCID: PMC6620678 |
29. Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A. The p52 isoform of SHC1 is a key driver of breast cancer initiation. Breast Cancer Res. 2019 Jun 15;21(1):74. PMCID: PMC6570928 |
30. Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ. Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome. Breast Cancer Res Treat. 2019 Aug;177(1):77-91. PMCID: PMC10317546 |
31. Liu N, Wang YA, Sun Y, Ecsedy J, Sun J, Li X, Wang P. Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines. Respir Res. 2019 Oct 23;20(1):230. PMCID: PMC6813099 |
32. Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C. Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury. Cancers (Basel). 2020 Apr 16;12(4). PMCID: PMC7226421 |
33. Odnokoz O, Yu P, Peck AR, Sun Y, Kovatich AJ, Hooke JA, Hu H, Mitchell EP, Rui H, Fuchs SY. Malignant cell-specific pro-tumorigenic role of type I interferon receptor in breast cancers. Cancer Biol Ther. 2020 Jul 02;21(7):629-636. PMCID: PMC7515508 |
34. Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, McCue PA, Shen D, Achilefu S, Rui H, Pestell RG. The membrane-associated form of cyclin D1 enhances cellular invasion. Oncogenesis. 2020 Sep 18;9(9):83. PMCID: PMC7501870 |
35. Cho C, Mukherjee R, Peck AR, Sun Y, McBrearty N, Katlinski KV, Gui J, Govindaraju PK, Puré E, Rui H, Fuchs SY. Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis. Oncogene. 2020 Sep;39(38):6129-6137. PMCID: PMC7502515 |
36. Chen S, Sun J, Zhao L, Sun Y, Jia D, Song Y, Luo J, Lei H, Liu N. Safety of apatinib plus S-1 for advanced solid tumor as palliative treatment. Exp Ther Med. 2021 Jan;21(1):62. PMCID: PMC7716638 |
37. Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y. Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. Pathol Res Pract. 2021 Apr;220:153380. PMCID: PMC7883708 |
38. Lu Z, Ortiz A, Verginadis II, Peck AR, Zahedi F, Cho C, Yu P, DeRita RM, Zhang H, Kubanoff R, Sun Y, Yaspan AT, Krespan E, Beiting DP, Radaelli E, Ryeom SW, Diehl JA, Rui H, Koumenis C, Fuchs SY. Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. J Clin Invest. 2021 May 17;131(10). PMCID: PMC8121529 |
39. Sun Y, Ge L, Udhane SS, Langenheim JF, Rau MJ, Patton MD, Gallan AJ, Felix JC, Rui H. Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues. Methods Protoc. 2021 Jul 10;4(3). PMCID: PMC8293419 |
40. Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H. Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness. Ann Diagn Pathol. 2021 Aug;53:151744. PMCID: PMC8053602 |
41. Sun Y, Yang N, Utama FE, Udhane SS, Zhang J, Peck AR, Yanac A, Duffey K, Langenheim JF, Udhane V, Xia G, Peterson JF, Jorns JM, Nevalainen MT, Rouet R, Schofield P, Christ D, Ormandy CJ, Rosenberg AL, Chervoneva I, Tsaih SW, Flister MJ, Fuchs SY, Wagner KU, Rui H. NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers. Sci Adv. 2021 Sep 17;7(38):eabc8145. PMCID: PMC8443188 |
42. Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ. Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. Cell Stress Chaperones. 2021 Sep;26(5):859-868. PMCID: PMC8357488 |
43. Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P. Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. Cancer Res. 2021 Oct 15;81(20):5336-5352. PMCID: PMC8530981 |
44. George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P. RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. 2021 Nov 02;37(5):109934. PMCID: PMC8675433 |
45. Maisel BA, Yi M, Peck AR, Sun Y, Hooke JA, Kovatich AJ, Shriver CD, Hu H, Nevalainen MT, Tanaka T, Simone N, Wang LL, Rui H, Chervoneva I. Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer. Cancers (Basel). 2022 Jan 08;14(2). PMCID: PMC8773496 |
46. Puzyrenko A, Felix JC, Ledeboer NA, Sun Y, Rui H, Sheinin Y. Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis. Pathology. 2022 Jun;54(4):404-408. PMCID: PMC8572726 |
47. Li Z, Jiao X, Robertson AG, Sante GD, Ashton AW, DiRocco A, Wang M, Zhao J, Addya S, Wang C, McCue PA, South AP, Cordon-Cardo C, Liu R, Patel K, Hamid R, Parmar J, DuHadaway JB, Jones SJ, Casimiro MC, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y, Iczkowski KA, Rui H, Pestell RG. The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses. Res Sq. 2023 Jan 10. PMCID: PMC9882663 |
48. Chervoneva I, Peck AR, Sun Y, Yi M, Udhane SS, Langenheim JF, Girondo MA, Jorns JM, Chaudhary LN, Kamaraju S, Bergom C, Flister MJ, Hooke JA, Kovatich AJ, Shriver CD, Hu H, Palazzo JP, Bibbo M, Hyslop T, Nevalainen MT, Pestell RG, Fuchs SY, Mitchell EP, Rui H. High PD-L2 Predicts Early Recurrence of ER-Positive Breast Cancer. JCO Precis Oncol. 2023 Jan;7:e2100498. PMCID: PMC9928763 |
49. Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ. Collagen-Specific HSP47<sup>+</sup> Myofibroblasts and CD163<sup>+</sup> Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. J Am Heart Assoc. 2023 Feb 21;12(4):e027990. PMCID: PMC10111490 |
50. George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P. RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. 2023 Mar 28;42(3):112228. PMCID: PMC10233815 |
51. Chaudhary LN, Jorns J, Sun Y, Cheng YC, Kamaraju S, Burfeind J, Gonyo M, Kong A, Patten C, Yen T, Cortina C, Carson E, Johnson N, Bergom C, Tsaih SW, Banerjee A, Wang Y, Chervoneva I, Weil E, Chitambar CR, Rui H. Frequent Upregulation Of HER2 Protein In Hormone Receptor-Positive HER2-Negative Breast Cancer After Short-Term Neoadjuvant Endocrine Therapy. Res Sq. 2023 Apr 07. PMCID: PMC10104267 |
52. Li Z, Jiao X, Robertson AG, Di Sante G, Ashton AW, DiRocco A, Wang M, Zhao J, Addya S, Wang C, McCue PA, South AP, Cordon-Cardo C, Liu R, Patel K, Hamid R, Parmar J, DuHadaway JB, Jones SJM, Casimiro MC, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y, Iczkowski KA, Rui H, Pestell RG. The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses. Oncogene. 2023 Jun;42(22):1857-1873. PMCID: PMC10238272 |
53. Yi M, Zhan T, Peck AR, Hooke JA, Kovatich AJ, Shriver CD, Hu H, Sun Y, Rui H, Chervoneva I. Selection of optimal quantile protein biomarkers based on cell-level immunohistochemistry data. BMC Bioinformatics. 2023 Jul 22;24(1):298. PMCID: PMC10363294 |
54. Yi M, Zhan T, Peck AR, Hooke JA, Kovatich AJ, Shriver CD, Hu H, Sun Y, Rui H, Chervoneva I. Quantile Index Biomarkers Based on Single-Cell Expression Data. Lab Invest. 2023 Aug;103(8):100158. PMCID: PMC10524910 |
55. Chaudhary LN, Jorns JM, Sun Y, Cheng YC, Kamaraju S, Burfeind J, Gonyo MB, Kong AL, Patten C, Yen T, Cortina CS, Carson E, Johnson N, Bergom C, Tsaih SW, Banerjee A, Wang Y, Chervoneva I, Weil E, Chitambar CR, Rui H. Frequent upregulation of HER2 protein in hormone-receptor-positive HER2-negative breast cancer after short-term neoadjuvant endocrine therapy. Breast Cancer Res Treat. 2023 Oct;201(3):387-396. |
56. Jacobs ER, Ross GR, Padilla N, Pan AY, Liegl M, Puzyrenko A, Lai S, Dai Q, Uche N, Rubenstein JC, North PE, Ibrahim EH, Sun Y, Felix JC, Rui H, Benjamin IJ. Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47<sup>+</sup> expression in cardiac myofibroblasts in situ. J Mol Cell Cardiol. 2023 Dec;185:1-12. |
