Faculty Collaboration Database -

CURRICULUM VITAE

Zeljko Bosnjak PhD, MS

Emeritus Professor
Department of Medicine
Division of Medicine Endocrinology


OFFICE ADDRESS:
8850 William Coffey Drive

Milwaukee, WI 53226
Phone: +1 (414) 9555687
Fax: 414-955-6507


EDUCATION:
1969 BS, University of Zagreb, Zagreb, Croatia
1972 MT, Marquette University, Milwaukee, WI
1979 PhD, Medical College of Wisconsin, Milwaukee, WI


FACULTY APPOINTMENTS:
1979 - 1981 Research Associate, Anesthesia Research Laboratory, Medical College of Wisconsin, Milwaukee, WI 53226
1981 - 1984 Assistant Professor, Departments of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226
1984 - 1989 Associate Professor, Departments of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226
1989 - Present Professor, Departments of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226
2003 - 2017 Vice Chairman for Research, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226
03/01/2018 - Present Professor, Department of Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226


AWARDS AND HONORS:
1982 NHLBI New Investigator Research Award "Ganglionic Modulation of Cardiac Autonomic Activity", National Heart, Lung, and Blood Institute
1986 IARS B.B. Sankey Anesthesia Advancement Award "Effect of Chronic Administration of Calcium Antagonists", International Anesthesia Research Society
1987 NHLBI Research Career Development Award "General Anesthesia and Cardiovascular Regulation", National Heart, Lung, and Blood Institute
1999 Republic of Croatia, Presidential medal "Northern Star" Rudjer Boskovic, National Decoration for Science
2001 President, World Association of Croatian Physicians
2004 Honorary doctorate degree from the University of Split, Split, Croatia, University of Split
2004 Evaluation Board Member, Faculty of 1000 Medicine
2006 Member, The National Foundation for Science of the Republic of Croatia
2006 Republic of Croatia, Presidential medal "Northern Star" Katarina Zrinski, National Decoration for Humanitarian Work
2008 ASA Excellence in Research Award, American Society of Anesthesiologists
2011 - Present Fellow of the American Heart Association (F.A.H.A.) , American Heart Association
2019 European Award for the promotion of International Relations, The University of Zagreb School of Medicine, Croatia


MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1979 British Brain Research Association
1979 European Brain and Behavior Society
1979 Society for Neurosciences
1979 American Physiological Society
1981 Society for Experimental Biology and Medicine
1983 American Association for the Advancement of Science
1984 - Present International Anesthesia Research Society
1986 - Present American Society of Anesthesiologists
1986 - Present Wisconsin Society of Anesthesiologists
1987 Cardiac Muscle Society
1989 Biophysical Society
1989 - Present Association of University Anesthesiologists
1990 - Present American Heart Association
1991 - Present Advisory Board: Croatian Medical Journal
1991 Board of Trustees: Croatian Institute for Brain Research
2003 German Anesthesia Society
2005 - Present Academy of Anesthesiology Mentors
2010 - Present International Society for Stem Cell Research
2013 - Present Malignant Hyperthermia Association of the United States (MHAUS)


EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
The Cardiovascular and Thoracic Anesthesia Journal Club
Editorial Board
Medicinski Vjesnik, Croatia
Croatian Medical Journal, Croatia
Acta Anaesthesiologica Croatica
Journal of Anesthesia, Japan
Journal Review
American Journal of Physiology
Canadian Journal of Physiology and Pharmacology
Hypertension
Brain Research
Croatian Medical Journal
Anesthesiology
Anesthesia and Analgesia


NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1984 - 1988 Session Chairman, FASEB Annual Meeting, American Physiological Society
1987 Member, National Science Foundation
1988 Member, Study Section II, National Institutes of Health Clinical Sciences
1989 Member, Special Review Committee, National Institute on Drug Abuse
1990 Member, Pharmacology II Study Section, National Institute on Drug Abuse
1990 Member, Contract Review Committee, National Institute on Drug Abuse
1990 Ad Hoc Surgery Member, Anesthesiology and Trauma Study Section, National Institutes of Health
1991 Site Visit- Vanderbilt University, HLBI Institute, National Institutes of Health
1991 Member, Pharmacology II Study Section, National Institute on Drug Abuse
1991 Site Visit- University of Virginia, HLBI Institute, National Institutes of Health
1991 - 1994 Member, Scientific Advisory Board, Association of University Anesthesiologists
1991 Reviewer, Medical Research Council of Canada
1991 Member, Pharmacology II Subcommittee, National Institute on Drug Abuse
1992 Site Visit- Vanderbilt University, HLBI Institute, National Institutes of Health
1992 - 1993 Session Chairman, FASEB Annual Meeting, American Physiological Society
1992 Session Chairman, Annual Meeting, American Society of Anesthesiologists
1992 Member, Subcommittee on Exp. Circulation, American Society of Anesthesiologists
1993 - 1999 Associate Editor, Anesthesiology
1993 - 1995 Reviewer, American Heart Association of Wisconsin
1994 - 1995 Session Chairman, Annual Meeting, American Society of Anesthesiologists
1994 - 1995 Member, Subcommittee on Exp. Circulation, American Society of Anesthesiologists
1995 Member, Special Review Committee, National Institute on Drug Abuse
1996 Site Visit - University of Pennsylvania, HLBI Institute, National Institutes of Health
1997 External Advisory Board Member, IARS Frontiers in Anesthesia Research Award, International Anesthesia Research Society
1997 - 1998 Ad Hoc - Surgery Member, Anesthesiology and Trauma Study Section, National Institutes of Health
1999 Special Review Committee Member, AG Institute, National Institutes of Health
1999 - 2008 Editor, Anesthesiology
2000 Chairman - External Advisory Board, Frontiers in Anesthesia Research Award, International Anesthesia Research Society
2000 - 2003 Surgery - Member, Anesthesiology and Trauma Study Section, National Institutes of Health
2003 - 2005 Chairman - Surgery, Anesthesiology and Trauma Study Section, National Institutes of Health
2003 Member, Subcommittee on Anesthetic Action and Biochemistry, American Society of Anesthesiologists
2006 Chairman, Ad Hoc - SAT Study Section Conflicts, National Institutes of Health
2006 Member, Approval Committee, Unity through Knowledge Fund, Croatia
2008 Member, Committee on Excellence in Research, American Society of Anesthesiologists


INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
International
"Ganglionic Modulations of Cardiac Autonomic Activity", Croatian Physiological Society, Zagreb, Croatia, 08/1984
"Long term effects of calcium antagonists", Croatian Physiological Society, Zagreb, Croatia, 06/1986
"Neuronal integration in the peripheral sympatheticganglia", Semmelweis Medical University, Budapest, Hungary, 06/1988
"Inhalational anesthetics and calcium sensitivity", University of Paris--Sud, Orsay, France, 07/1989
"Cellular effects of anesthetics", University of Graz, Graz, Austria, 05/1992
"Mechanism of myocardial contraction and the effects of anesthetics", University of Zagreb, Zagreb, Croatia, 05/1992
"Inhalational Anesthesia", Munich, Germany, 03/1993
"Cardiac Electrophysiology", Split, Croatia, 03/1993
"Mechanisms and management of cardiac dysrhythmias" and "Effects of E047/1 on cardiac electrophysiology", Salzburg, Austria, 10/1993
"Ion channels in vascular smooth muscle", Leuven, Belgium, 10/1993
"Cardioprotective effects of BPC" and "Mechanisms and management of cardiac dysrhythmias", University of Zagreb, Zagreb, Croatia, 11/1993
"Cardiac cellular effects of anesthetics", Split, Croatia, 06/1994
"Cellular effects of anesthetics in the heart", Heidelberg, Germany, 10/1995
"Cellular effects of anesthetics" and "Mechanisms f cardiac dysrhythmias during anesthesia", Asahikawa, Fukuoka, and Sapporo, Japan, 09/1996
"Mechanisms of cardiac dysrhythmias during anesthesia", Heidelberg, Germany, 11/1996
"Cardiac effects of anesthetics", Mostar, Bosnia and Herzegovina, 11/1996
"Anesthetics and cardiac electrophysiology", Opatija, Croatia, 05/1997
"Anesthetics and cardiac signal transduction", Frankfurt, Germany, 07/1998
"Volatile anesthetic-induced cardioprotection", Asahikawa, Sapporo, Tokyo, and Toyama, Japan, 05/1999
"Cellular effects of anesthetics in the heart", Graz, Austria & Zagreb, Croatia, 09/1999
"Anesthesiology Research in 21st Century" and "How to write and publish the manuscripts", Japanese Society of Anesthesiologists Annual Meeting, Kobe, Japan, 04/2001
"Anesthetic-induced cardiac preconditioning", International Conference on Molecular and Basic Mechanisms of Anesthesia, Gustav-Stresemann-Institute, University of Bonn, Bonn, Germany, 06/2001
"Cardiac protection", Split, Croatia, 09/2001
"Role of diaspora in Croatian science", WACP Meeting, Zagreb, Croatia, 05/2002
"Anesthesiology Research in 21st Century", Wurzburg, Germany, 04/2003
"Cardioprotective effects of anesthetics" and "Anesthesiology Research in 21st Century", Aegean Anesthesia Conference, Crete, Greece, 05/2003
"Role of Diaspora in Advancement of Croatian Science", Split, Croatia, 09/2003
"Cardiac preconditioning against ischemia/reperfusion injury", Croatian Cardiac Society Meeting, Opatija, Croatia, 05/2004
"Role of Diaspora in Advancement of Croatian Science", Visiting Professor, Zagreb, Croatia, 11/2004
“Does Basic Research in Cardiac Anesthesia Improve the Clinical Outcome?”, Fast Track Anesthesia Conference, University of Athens,, Athens, Greece, 03/2005
"Future of anesthesiology research", University of Rijeka, Rijeka, Croatia, 05/2005
"Anesthetic-induced preconditioning", Anesthesia Symposium, Dubrovnik, Croatia., 05/2005
"Cardiac preconditioning by volatile anesthetics", Visiting Professor, Trondheim, Norway, 09/2005
"Anesthesiology research in the 21st century", Visiting Professor, University of Zagreb, Zagreb, Croatia, 09/2005
"Future of anesthesiology research", University of Zagreb, Zagreb, Croatia, 06/2006
"Cardiac Preconditioning", Alpa-Adria Anesthesia Symposium, Opatija, Croatia, 09/2006
"Anesthetic-induced preconditioning" and "How to write and publish the manuscripts in Anesthesiology", Japan Society of Clinical Anesthesiology, Asahikawa, Sapporo, and Tokyo, Japan, 10/2006
"Anesthetics and cardioprotection", Co-organizer, European-American Anesthesia Conference, Dubrovnik, Croatia, 05/2007
"Anesthetic preconditioning", Goettingen, Germany, 10/2007
"History of Anesthesiology Research", Heidelberg, Germany, 10/2007
"Anesthetic-induced protection", Zagreb Medical School, Zagreb, Croatia, 10/2008
"Protection against Ischemia and Reperfusion Injury", Jerusalem, Israel, 12/2008
"Cardiac Protection with Inhalational Anesthetics", Co-organizer, European-American Anesthesia Conference, Dubrovnik, Croatia, 04/2009
"Human embryonic and induced pluripotent stem cell-derived cardiomyocytes and anesthetic cardiac preconditioning", University of Rijeka, Rijeka, Croatia, 12/2009
"The use of induced pluripotent stem cells in anesthesia research", University of Regensburg, Regensburg, Germany, 12/2009
"Protection against ischemia and reperfusion injury" and "Cardiac protection with inhalational anesthetics", Seoul National University, Seoul, South Korea, 04/2010
"Cardiac protection with inhalational anesthetics" and "Human embryonic and induced pluripotent stem cells-derived cardiomyocytes and cardiac preconditioning", Annual Meeting of KSCVA, Daegu, South Korea, 04/2010
"Human stem cell-derived cardiomyocytes and anesthetic preconditioning", "Developmental neurotoxicity", "Organoprotection by volatile anesthetics", and "Brain protection during cardiac surgery", Co-organizer, European-American Anesthesia Conference, Dubrovnik, Croatia, 05/2011
"Stem cell biology and anesthesia research", "Neurotoxicity of anaesthetic agents", and "Brain Preconditioning: Is there a challenge?", 19th Panhellenic Congress of Anaesthesiology, Alexandroupolis, Greece, 05/2011

National
"Cellular Characteristics of the Stellate Ganglion and their Relationship to Cardiac Function", FASEB Summer Research Conference, Saxtons River, Vermont, 06/1984
"Effects of Verapamil and Halothane on Changes of Intracellular Free Calcium Concentrations, Transmembrane Potentials and Contractile Properties of the Papillary Muscle", Research Workshop: Interaction between Calcium Channel Blockers and Anesthesia, Houston, Texas, 09/1984
"Integrative neuromodulation in paravertebral ganglia", FASEB Symposium: Ganglionic control of autonomic effector systems, Anaheim, California, 04/1985
"Sensory mechanisms in sympathetic ganglia" and "Pulmonary and cardiovascular afferents to the stellate ganglion", Neuromuscular Symposium, Dallas, Texas, 10/1985
"Cardiac protection with halothane associated with post-ischemia or calcium paradox in isolated guinea pig hearts", VIIth International Spring Symposium:Cell Calcium Metabolism, Washington, DC, 05/1987
"Differential effects of halothane, enflurane, and isoflurane on calcium currents and transients", Workshop on subcellular mechanisms of anesthetic action in muscle., Augusta, Georgia, 09/1988
"Effects of inhalational anesthetics on calcium currents and transients", Emory University, Atlanta, Georgia, 03/1989
"Cardiac Electrophysiology", Department of Anesthesiology, The Johns Hopkins University, Baltimore, Maryland, 06/1989
"Suppression of cardiac Ca2+channel currents by halothane, enflurane, and isoflurane", Association of University Anesthesiologists (AUA) Meeting, Seattle, Washington, 05/1990
"Mechanisms of anesthetic action in cardiac muscle", Symposium, Baltimore, Maryland, 09/1990
"Effects of anesthetics on myocardial contractility", Clemson University, Clemson, South Carolina, 03/1991
"Effects of halothane on calcium and potassium currents in isolated smooth muscle cells of dog coronary arteries", Association of University Anesthesiologists (AUA) Meeting, Philadelphia, Pennsylvania, 05/1991
"Receptor Pharmacology", Department of Anesthesiology, Washington University, St Louis, Missouri, 10/1991
"Smooth Muscle Electrophysiology", American Society of Anesthesiologists (ASA) Meeting, San Francisco, California, 10/1992
"Cellular effects of anesthetics in the heart", Massachusetts General Hospital, Boston, Massachusetts, 01/1995
"Cellular mechanisms of anesthetics", Columbia University, New York, New York, 04/1997
"Cardioprotective effects of anesthetics", Cleveland Clinic Foundation, Cleveland, Ohio, 06/2000
"Myocardial Protection", American Society of Anesthesiologists (ASA) Annual Meeting, Panel on Organ Protection, San Francisco, California, 10/2000
"Effects of anesthetics on the Heart", Brigham & Women's Hospital, Boston, Massachusetts, 11/2000
"Anesthesiology Research in 21st Century" and "Anesthetic-induced cardiac preconditioning", Visiting Professor, UCLA, Los Angeles, California, 02/2004
"Cardiac protection", Visiting Professor, Louisiana State University, New Orleans, Louisiana, 10/2004
The Twenty-Eighth Emanuel M. Papper Lecture: "Anesthetic-induced cardioprotection", Visiting Professor, Columbia University, New York, New York, 12/2004
"Anesthetic-Induced Cardioprotection", Massachusetts General Hospital, Boston, Massachusetts, 06/2006
"Basic Cardiac Electrophysiology", Brigham & Women's Hospital, Boston, Massachusetts, 11/2006
"Protection against ischemia-reperfusion injury", American Society of Anesthesiologists (ASA) Meeting, San Francisco, California, 10/2007
"Role of mitochondria in APC", MCW, Department of Physiology, Milwaukee, Wisconsin, 12/2007
"Protection against ischemia", Rutgers New Jersey Medical School (UMDNJ), Newark, New Jersey, 06/2008
"Successful Approaches to Mentoring", American Society of Anesthesiologists (ASA) Annual Meeting, Orlando, Florida, 10/2008
"6th Annual Celebration of Research", American Society of Anesthesiologists (ASA) Annual Meeting, Orlando, Florida, 10/2008
"Cardiomyocytes Derived from Human Embryonic Stem Cells as a Model of Anesthetic Preconditioning", Galveston, Texas, 04/2009


Regional
"Sympathetic Ganglionic Reflexes", Cardiac Neuro-Control Symposium, Chicago, Illinois, 04/1981
"The Effects of Halothane and Calcium Channel Blockers on Transmembrane Potentials Intracellular Calcium Ion Transients and Contractile Properties of Cat Papillary Muscle", Association of University Anesthesiologists (AUA) meeting, Madison, Wisconsin, 05/1984
"Cardiac electrophysiology- automaticity"; "Cardiac electrophysiology-conduction"; "Cardiac effects of anesthetics", University of Chicago, Chicago, Illinois, 05/1991
"Myocardial Protection", Dept. of Anesthesiology, University of Wisconsin--Madison, Madison, Wisconsin, 11/2002
"Graduate education in Physiology", University of Wisconsin--Green Bay, Green Bay, Wisconsin, 11/2002
"Anesthetic-induced preconditioning", American Heart Association meeting, Chicago, Illinois, 11/2006


COMMITTEE SERVICE:
Medical College of Wisconsin
1984 - 1994 Member, Curriculum Committee, Anesthesiology, MCW
1984 - 1987 Advisor, PhD Thesis Committee for Zeljko Dujic, MD Thesis: "Modulation of Acetylcholine Release and Ganglionic Synaptic Transmission in the Stellate Ganglia", MCW
1988 - 1992 Member, Strategic Research Planning Committee, MCW
1989 - 1999 Member, Ad Hoc Committee for Residency Recruitment, Anesthesiology, MCW
1989 Chairman, Physiology Intramural Review Committee, MCW
1990 - 1996 Member, Graduate Division - Admissions and Welfare Committee, MCW
1990 Member, PhD Thesis Committee for Xiaohe Xi, Physiology, Loyola University
1991 Member, PhD Thesis Committee for Hassane Sobhi Mchaourab, MCW
1992 - Present Member, Research Committee, Anesthesiology, MCW
1994 - 2001 Member, Animal Care and Use Committee, MCW
1997 - 2003 Member, Clinical Sciences Advisory Committee, MCW
1999 - 2000 Member, Faculty Council, MCW
2002 - 2005 Member, Nominating Committee of the Faculty Council, MCW
2002 - 2006 Member, MSTP Admissions Committee, MCW
2002 - 2008 Member, Admissions Committee, MCW
2003 - 2007 Advisor, PhD Thesis Committee for Marko Ljubkovic, MCW
2003 - 2007 Advisor, PhD Thesis Committee for Jasna Marinovic, MCW
2006 - Present Member, DSHREP (formerly MSRTP) Steering Committee, MCW
2006 - 2010 Advisor, PhD Thesis Committee for Filip Sedlic, MCW
2007 - 2009 Advisor, PhD Thesis Committee for Danijel Pravdic, MCW
2009 Advisor, PhD Thesis Committee for Scott Canfield, MCW
2009 - Present Member, GSC Program Evaluation Committee, MCW
2010 - Present Member, Clinical & Translational Science Institute-Mentoring Committee, MCW
2010 - Present Member, Office of Research Innovation - Administration Task Force, MCW
2010 - Present Member, CVC Search Committee, MCW


MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Faculty
1980 - 1985 David Stowe, MD, PhD, MCW
1982 - 1985 Lawrence Turner, MD, MCW
1982 - 1984 Susan Palmer, MD, MCW
1985 - 1989 Anil Aggarwal, MD, MCW
1986 - 1990 Eugene Cheng, MD, MCW
1986 - 1987 Daniel Siker, MD, MCW
1987 - 1989 Robert Schoen, DO, PhD, MCW
1988 - 1990 John L. Atlee, MD, MCW
1989 - 1994 Barbara Palmisano, MD, MCW
1989 - 1992 Heinrich K. Schedewie, MD, MCW
1990 - 1993 Hanna Eskinder, PhD, MCW
1990 - 1992 Alan Goldberg, MD, PhD, MCW
1990 - 1991 Quinn Hogan, MD, MCW
1991 - 1993 Harvey Woehlck, MD, MCW
1993 - 1995 Anna Stadnicka, PhD, MCW
2010 - Present Xiaowen Bai, MD, PhD, MCW


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Palmer SK, Zuperku EJ, Bosnjak ZJ, Coon RL, Kampine JP. Halothane, tracheal compliance and upper-airway mechanoreceptors. Anesthesiology, 1978;49:260-265.
2. Bosnjak ZJ, Zuperku EJ, Coon RL, Kampine JP. Acute coronary artery occlusion and cardiac sympathetic afferent nerve activity. Proc Soc Exp Biol Med, 1979;161:142-148.
3. Bosnjak ZJ. Segmental coronary artery occlusion: Afferent cardiac sympathetic nerve activity and effect of nitroglycerin. Thesis (Ph.D.) Medical College of Wisconsin. Department of Physiology, 1979.
4. Bosnjak ZJ, Seagard JL, Zuperku EJ, Coon RL, Singh HM, Bamrah VS, Kampine JP. Segmental ventricular adjustments to brief periods of ischemia in the dog. Can J Physiol Pharmacol, 1981;59:287-292.
5. Bachhuber SR, Seagard JL, Bosnjak ZJ, Kampine JP. The effect of halothane on reflexes elicited by acute coronary artery occlusion in the dog. Anesthesiology, 1981;54:481-487.
6. Bosnjak ZJ, Bamrah BS, Seagard JL, Kampine JP. Excitation of afferent cardiac sympathetic nerves is modulated by nitroglycerin. Proc Soc Exp Biol Med, 1981;166:398-404.
7. Bosnjak ZJ, Seagard JL, Kampine JP. Peripheral neural input to neurons of the stellate ganglion in the dog. Am J Physiol, 1982;242(11):R237-243.
8. Bosnjak ZJ and Kampine JP. Intracellular recordings from the stellate ganglion of the cat. J Physiol (London), 1982;324:273-283.
9. Bosnjak ZJ, Seagard JL, Wu A, Kampine JP. The effects of halothane on sympathetic ganglionic transmission. Anesthesiology, 1982;57:473-479.
10. Bosnjak ZJ and Kampine JP. Effects of halothane, enflurane and isoflurane on the SA node. Anesthesiology, 1983;58:314-321.
11. Palmer SK, Bosnjak ZJ, Hopp FA, von Colditz JH, Kampine JP. Lidocaine and bupivacaine differential blockade of isolated canine nerves. Anesth Analg, 1983;62:754-757.
12. Seagard JL, Elegbe EO, Hopp FA, Bosnjak ZJ, von Colditz JH, Kalbfleisch JH, Kampine JP. Effects of isoflurane on the baroreceptor reflex. Anesthesiology, 1983;59:511-520.
13. Seagard JL, Hopp FA, Bosnjak ZJ, Elegbe EO, Kampine JP. Extent and mechanism of halothane sensitization of the carotid sinus baroreceptors. Anesthesiology, 1983;58:432-437.
14. Bosnjak ZJ and Kampine JP. Peripheral neural input to neurons of the middle cervical ganglion in the cat. Am J Physiol, 1984;246(15):R354-R358.
15. Seagard JL, Hopp FA, Bosnjak ZJ, Osborn JL, Kampine JP. Sympathetic efferent nerve activity in conscious and isoflurane-anesthetized dogs. Anesthesiology, 1984;61:266-270.
16. Stowe DF, Bosnjak ZJ, Kampine JP. Halothane diminishes changes in cardiac fiber action potential duration induced by hypocarbia and hypercarbia. Anesthesiology, 1984;61:245-253.
17. Turner LA, Zuperku EJ, Bosnjak ZJ, Kampine JP. Autonomic modulation of refractoriness in the canine specialized His-Purkinje system. Am J Physiol, 1985;248(17):R515-R523.
18. Stowe DF, Bosnjak ZJ, Kampine JP. Effect of hypoxia on adult and neonatal pacemaker rates. Obstet Gynecol, 1985;66:649-656.
19. Kostreva DR, Armour JA, Bosnjak ZJ. Metabolic mapping of a cardiac reflex mediated by sympathetic ganglia in the dog. Am J Physiol, 1985;249:R317-R322.
20. Bosnjak ZJ and Kampine JP. Electrophysiological and morphological characterization of neurons in stellate ganglion of cat. Am J Physiol, 1985;248(17):R288-R292.
21. Bosnjak ZJ. Ganglionic modulation of cardiac autonomic activity. Periodicum Biologorum, 1985;87(1):27-32.
22. Bosnjak ZJ, Stowe DF, Kampine JP. Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. Anesth Analg, 1986;65:911-917.
23. Stowe DF, Bosnjak ZJ, Kampine JP. Cardiac cell action potential duration is dependent upon induced changes in Ca2+ activity during pH changes in vitro. J Electrocardiol, 1986;19(2):143-154.
24. Bosnjak ZJ, Seagard JL, Roerig DL, Kostreva DR, Kampine JP. Effects of morphine on sympathetic transmission in the stellate ganglion of the cat. Can J Physiol Pharmacol, 1986;64:940-946.
25. Bosnjak ZJ, and Kampine JP. Effects of halothane on transmembrane potentials, Ca2+ transients, and papillary muscle tension in the cat. Am J Physiol, 1986;251(20):H374-H381.
26. Turner LA, Bosnjak ZJ, Kampine JP. Action of halothane on the electrical activity of Purkinje fibers derived from normal and infarcted canine hearts. Anesthesiology, 1987;67:619-629.
27. Hoka S, Siker D, Bosnjak ZJ, Kampine JP. Alteration of blood flow distribution and vascular capacitance during induced hypotension in deafferented dogs. Anesthesiology, 1987;66:647-652.
28. Hoka S, Bosnjak ZJ, Kampine JP. Halothane inhibits calcium accumulation following myocardial ischemia and calcium paradox in guinea pig hearts. Anesthesiology, 1987;67:197-202.
29. Bosnjak ZJ. Let's have "sympathy". Anesthesiology, 1988;69:806.
30. Stowe DF, Dujic Z, Bosnjak ZJ, Kalbfleisch JH, Kampine JP. Effects of inhalational anesthetics and sympathomimetics on the SA node. Anesthesiology, 1988;68:887-894.
31. Stowe DF, Bosnjak ZJ, Marijic J, Kampine JP. Effects of halothane with and without histamine and/or epinephrine on automaticity, intracardiac conduction times and development of dysrhythmias in the isolated guinea pig heart. Anesthesiology, 1988;68:695-706.
32. Hoka S, Bosnjak ZJ, Seagard JL, Siker D, Palmisano BW, Coon RL, Kampine JP. Left ventricular reflex control of venous return and systemic vascular capacitance in dogs. Can J Physiol Pharmacol, 1988;66:112-118.
33. Hoka S, Bosnjak ZJ, Siker D, Luo R, Kampine JP. Dynamic changes in venous outflow by baroreflex and left ventricular distension. Am J Physiol, 1988;254(23):R212-R221.
34. Marijic J, Bosnjak ZJ, Stowe DF, Kampine JP. Effects and interaction of verapamil and volatile anesthetics on the isolated perfused guinea pig heart. Anesthesiology, 1988;69:914-922.
35. Bosnjak ZJ, Dujic Z, Roerig DL, Kampine JP. Effects of halothane on acetylcholine release and sympathetic ganglionic transmission. Anesthesiology, 1988;69:500-506.
36. Hoka S, Bosnjak ZJ, Arimura H, Kampine JP. Regional venous outflow, blood volume and sympathetic nerve activity during severe hypoxia. Am J Physiol, 1989;256(25):H162-H170.
37. Bosnjak ZJ and Kampine JP. Cardiac sympathetic afferent cell bodies located in the peripheral autonomic nervous system of the cat. Circ Res, 1989;64:554-562.
38. Ozono K, Bosnjak ZJ, Kampine JP. Reflex control of mesenteric vein diameter and pressure in situ in rabbits. Am J Physiol, 1989;256(25): H1066-H1072.
39. Cheng EY, Kay J, Hoka S, Bosnjak ZJ, Coon RL, Seagard JL, Kampine JP. Influence of lung inflation reflex on vascular capacitance in systemic circulation. Am J Physiol, 1989;257(26)R1004-R1011.
40. Atlee JL and Bosnjak ZJ. Mechanisms for cardiac dysrhythmias during anesthesia. Anesthesiology, 1990;72:347-374.
41. Turner LA, Marijic J, Kampine JP, Bosnjak ZJ. A comparison of the effects of halothane and tetrodotoxin on the regional repolarization characteristics on canine Purkinje fibers. Anesthesiology, 1990;73:1158-1168.
42. Dujic Z, Bosnjak ZJ, Schedewie H, Roerig DL, Kampine JP. Presynaptic modulation of ganglionic ACh release by muscarinic and nicotinic receptors. Am J Physiol, 1990;259(28)R288-R293.
43. Atlee JL, Bosnjak ZJ, Yeager TS. Effects of diltiazem, verapamil and inhalational anesthetics on electrophysiologic properties affecting reentrant supraventricular tachycardia in chronically instrumented dogs. Anesthesiology, 1990;72:889-901.
44. Marijic J, Stowe DF, Turner LA, Kampine JP, Bosnjak ZJ. Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart. Anesthesiology, 1990;73:976-983.
45. Marijic J, Madden JA, Kampine JP, Bosnjak ZJ. The effects of halothane on norepinephrine responsiveness in rabbit small mesenteric veins. Anesthesiology, 1990;73:479-484.
46. Stowe DF, Monroe S, Marijic J, Rooney RT, Bosnjak ZJ, Kampine JP. Effects of nitrous oxide on contractile function and metabolism of the isolated heart. Anesthesiology, 1990;73:1220-1226.
47. Sprung J, Gamulin S, Bosnjak ZJ, Kampine JP. Potassium correction of hypothermic hypokalemia induces hyperkalemia after rewarming. Can J Anaesth, 1990;37:S69.
48. Stekiel TA, Ozono K, McCallum JB, Bosnjak ZJ, Kampine JP. The inhibitory action of halothane on reflex constriction in mesenteric capacitance veins. Anesthesiology, 1990;73:1169-1178.
49. Ozono K, Bosnjak ZJ, Kampine JP. Effect of sympathetic tone on pressure-diameter relationship of rabbit mesenteric veins in situ. Circ Res, 1991;68:888-896.
50. Bosnjak ZJ, Marijic J, Roerig DL, Stowe DF, Murthy VS, Kampine JP. Chronic verapamil treatment depresses automaticity and contractility in isolated cardiac tissues. Anesth Analg, 1991;72:462-468.
51. Gallenberg LA, Stowe DF, Marijic J, Kampine JP, Bosnjak ZJ. Depression of atrial rate, atrioventricular nodal conduction and cardiac contraction by diltiazem and volatile anesthetics in isolated hearts. Anesthesiology, 1991;74:519-530.
52. Rooney J, Marijic J, Stowe DF, Kampine JP, Bosnjak ZJ. Additive depressant effects of amiodarone given with halothane in isolated hearts. Anesth Analg, 1991;72:474-481.
53. Bosnjak ZJ, Supan FD, Rusch NJ. The effects of halothane, enflurane and isoflurane on calcium current in isolated canine ventricular cells. Anesthesiology, 1991;74:340-345.
54. Rooney RT, Stowe DF, Marijic J, Bosnjak ZJ, Kampine JP. Amrinone reverses cardiac depression and augments coronary vasodilatation with isoflurane in the isolated heart. Anesthesiology, 1991;74:559-567.
55. Eskinder H, Rusch NJ, Supan FD, Kampine JP, Bosnjak ZJ. The effects of volatile anesthetics on L- and T-type calcium channel currents in canine cardiac Purkinje cells. Anesthesiology, 1991;74:919-926.
56. Bosnjak ZJ and Turner LA. Halothane, catecholamines, and cardiac conduction: anything new? Anesth Analg 1991;72:1-4.
57. Bosnjak ZJ. General anesthetics and cardiac function. Periodicum Biologorum, 1991;93:509-518.
58. Marijic J, Buljubasic N, Stowe DF, Turner LA, Kampine JP, Bosnjak ZJ. Opposing effects of diacetylmonoxime on contractility and calcium transients in isolated myocardium. Am J Physiol, 1991;260:H1153-1159.
59. Stowe DF, Marijic J, Bosnjak ZJ, Kampine JP. Direct comparative effects of halothane, enflurane and isoflurane on oxygen supply and demand in isolated hearts. Anesthesiology, 1991;74:1087-1095.
60. Laszlo A, Polic S, Atlee JL, Kampine JP, Bosnjak ZJ. Anesthetics and automaticity in latent pacemaker fibers. I. Effects of halothane, enflurane and isoflurane on automaticity and recovery of automaticity from overdrive suppression in Purkinje fibers derived from canine hearts. Anesthesiology, 1991;75:98-105.
61. Sprung J, Cheng EY, Bosnjak ZJ. Hypothermia and serum potassium concentration. Correspondence. Anesthesiology, 1991;75:164.
62. Arimura H, Bosnjak ZJ, Hoka S, Kampine JP. Modifications by halothane of responses to acute hypoxia in systemic vascular capacitance, resistance, and sympathetic nerve activity in dogs. Anesth Analg. 1991;73:319-326.
63. Sprung J, Cheng EY, Gamulin S, Kampine JP, Bosnjak ZJ. Effects of acute hypothermia and beta-adrenergic receptor blockade on serum potassium concentration in rats. Crit Care Med, 1991;19:1545-1551.
64. Polic S, Atlee JL, Laszlo A, Kampine JP, Bosnjak ZJ. Anesthetics and automaticity in latent pacemaker fibers. II Effects of halothane and epinephrine or norepinephrine on automaticity of dominant and subsidiary atrial pacemakers in the canine heart. Anesthesiology 1991;75:298-304.
65. Polic S, Atlee JL, Laszlo A, Kampine JP, Bosnjak ZJ. Anesthetics and automaticity in latent pacemaker fibers. III. Effects of halothane and ouabain on automaticity of the SA node and subsidiary atrial pacemakers in the canine heart. Anesthesiology, 1991;75:305-312.
66. Polic S, Bosnjak ZJ, Marijic J, Hoffman RG, Kampine JP, Turner LA. Actions of halothane, enflurane and isoflurane on the regional action potential characteristics of canine Purkinje fibers. Anesth Analg, 1991;73:603-611.
67. Buljubasic N, Marijic J, Stowe DF, Gross GJ, Kampine JP, Bosnjak ZJ. Comparative cardiac effects of KT-362 and verapamil in isolated hearts- Correlation to calcium channel current depression. J Cardiovasc Pharm, 1991;18:594-604.
68. Laszlo A, Polic S, Kampine JP, Turner LA, Atlee JL, Bosnjak ZJ. Halothane, enflurane and isoflurane on abnormal automaticity and triggered rhythmic activity of Purkinje fibers from 24-hour-old canine hearts. Anesthesiology, 1991;75:847-853.
69. Flynn NM, Kenny D, Pelc LR, Warltier DC, Bosnjak ZJ, Kampine JP. Endothelium-dependent vasodilation of canine coronary collateral vessels. Am J Physiol, 1991;261:H1797-H1801.
70. Stowe DF, Monroe SM, Marijic J, Bosnjak ZJ, Kampine JP. Comparison of halothane, enflurane and isoflurane with nitrous oxide on contractility and oxygen supply and demand in isolated hearts. Anesthesiology, 1991;75:1062-1074.
71. Rosenfeld BA, Bosnjak ZJ, Shapiro RM, Dorman T, Ligier B, Breslow MJ. Negative chronotropic factor in patients with fungemia. Crit Care Med, 1992;20:327-331.
72. Buljubasic N, Marijic J, Stowe DF, Kampine JP, Bosnjak ZJ. Halothane reduces dysrhythmias and improves contractile function after global hypoperfusion in isolated hearts. Anesth Analg, 1992;74:384-394.
73. Flynn NM, Buljubasic N, Bosnjak ZJ, Kampine JP. Isoflurane produces endothelium-independent relaxation in canine middle cerebral arteries. Anesthesiology, 1992;76:461-467.
74. Bosnjak ZJ, Aggarwal A, Turner LA, Kampine JP. Differential effects of halothane, enflurane and isoflurane on Ca2+ transients, and papillary muscle tension in guinea pigs. Anesthesiology, 1992;76:123-131.
75. Cheng EY, Kay J, Hoka S, Bosnjak ZJ, Coon RL, Kampine JP. The influence of isoflurane on the vascular reflex response to lung inflation in dogs. Anesthesiology, 1992;76:972-978.
76. Eskinder H, Gross GJ, Supan FD, Kampine JP, Bosnjak ZJ. Effects of KT-362, a novel calcium antagonist, on calcium channel current in single canine cardiac ventricular cells. Pharmacol Commun, 1992;1:37-43.
77. Buljubasic N, Rusch NJ, Marijic J, Kampine JP, Bosnjak ZJ. Effects of halothane and isoflurane on calcium and potassium channel currents in canine coronary arterial cells. Anesthesiology, 1992;76:990-998.
78. Buljubasic N, Flynn MN, Marijic J, Rusch NJ, Kampine JP, Bosnjak ZJ. Effects of isoflurane on K+ and Ca2+ conductance in isolated smooth muscle cells of canine cerebral arteries. Anesth Analg, 1992;75:590-596.
79. Dujic Z, Marijic J, Roerig DL, Kampine JP, Bosnjak ZJ. Effects of opioid analgesics on acetylcholine release and ganglionic transmission in the stellate ganglion of the cat. Croatian Med J, 1992;33:91-101.
80. Stowe DF, Bosnjak ZJ, Kampine JP. Comparison of etomidate, ketamine, midazolam, propofol and thiopental on function and metabolism of isolated hearts. Anesth Analg, 1992;74:547-558.
81. Laszlo A, Buljubasic N, Zsolnai B, Kampine JP, Bosnjak ZJ. Interactive effects of volatile anesthetics, verapamil and ryanodine on contractility and calcium urrent ion of isolated pregnant rat myometrium. Am J Obstet Gynecol, 1992;167:804-810.
82. Marijic J, Buljubasic N, Coughlan MG, Kampine JP, Bosnjak ZJ. Effect of K+ channel blockade with tetraethylammonium on anesthetic-induced relaxation in canine cerebral and coronary arteries. Anesthesiology, 1992;77:948-955.
83. Coughlan MG, Lee JG, Bosnjak ZJ, Schmeling WT, Kampine JP, Warltier DC. Direct coronary and cerebral vascular responses to dexmedetomidine: Significance of endogenous nitric oxide synthesis. Anesthesiology, 1992;77:998-1006.
84. Stekiel TA, Tominaga M, Bosnjak ZJ, Kampine JP. The inhibitory effect of halothane on mesenteric venoconstriction and related reflex responses during acute graded hypoxia in rabbits. Anesthesiology, 1992;77:709-720.
85. Boban M, Stowe DF, Buljubasic N, Kampine JP, Bosnjak ZJ. Direct comparative effects of isoflurane and desflurane in isolated guinea pig hearts. Anesthesiology, 1992;76:775-780.
86. Hoka S, Arimura H, Bosnjak ZJ, Kampine JP. Regional venous outflow, blood volume and sympathetic nerve activity during hypercapnia and hypoxic hypercapnia. Can J Physiol Pharmacol, 1992;70:1032-1039.
87. Sprung J, Cheng EY, Gamulin S, Kampine JP, Bosnjak ZJ. The effect of acute hypothermia and serum potassium concentration on potassium cardiotoxicity in anesthetized rats. Acta Anaesth Scand, 1992;36:825-830.
88. Eskinder H, Hillard CJ, Flynn NM, Bosnjak ZJ, Kampine JP. Role of Guanylate cyclase-cGMP systems in halothane-induced vasodilatation in canine cerebral arteries. Anesthesiology, 1992;77:482-487.
89. Arimura H, Bosnjak ZJ, Kampine JP. Catecholamine-induced changes in vascular capacitance and sympathetic nerve activity in dogs. Can J Physiol Pharmacol, 1992;70:1021-1031.
90. Dujic Z, Marijic J, Roerig DL, Kampine JP, Bosnjak ZJ. Presynaptic modulation of acetylcholine release from the cat stellate ganglion by morphine. Croatian Med J, 1993;34(1)33-42.
91. McCallum JB, Stekiel TA, Bosnjak ZJ, Kampine JP. Does isoflurane alter mesenteric venous capacitance in the intact rabbit? Anesth Analg, 1993;76:1095-1105.
92. Gallenberg LA, Stowe DF, Kampine JP, Bosnjak ZJ. Effects of nifedipine with isoflurane, halothane or enflurane on automaticity, conduction and contractility in isolated guinea pig hearts. Anesthesiology, 1993;78:1112-1119.
93. Eskinder H, Supan FD, Turner LA, Kampine JP, Bosnjak ZJ. The effects of halothane and isoflurane on slowly inactivating sodium current in canine cardiac Purkinje cells. Anesth Analg, 1993;77:32-37.
94. Boban M, Stowe DF, Kampine JP, Goldberg AH, Bosnjak ZJ. Effects of 2,3 butanedione monoxime in isolated hearts; Protection during reperfusion following global ischemia. J Thorac Cardiovasc Surg, 1993;105:532-540.
95. Coughlan MG, Kenny D, Kampine JP, Bosnjak ZJ, Warltier DC. Differential effects on sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or inhibition of nitric oxide synthesis. Cardiovasc Res, 1993;27:1444-1448.
96. O'Brien P, Bosnjak ZJ, Warltier DC. Recovery of contractile function of postischemic, reperfused myocardium: influence of 2,3-Butanedione-2-monoxime, an agent that inhibits excitation-contraction coupling. J Cardiovasc Pharm, 1993;21:693-700.
97. Stadnicka A, Flynn NM, Bosnjak ZJ, Kampine JP. Enflurane, halothane and isoflurane attenuate contractile responses to exogeneous and endogenous norepinephrine in isolated small mesenteric veins of the rabbit. Anesthesiology, 1993;78:326-334.
98. Tudoric N, Coon RL, Flynn NM, Bosnjak ZJ. Inhibition of neutral endopeptidase augments anaphylactic constriction of guinea pig tracheal smooth muscle. Int Arch Allergy Immunol, 1993;100:170-177.
99. Buljubasic N, Stowe DF, Marijic J, Roerig DL, Kampine JP, Bosnjak ZJ. Halothane reduces release of adenosine, inosine and lactate with ischemia and reperfusion in isolated hearts. Anesth Analg, 1993;75:54-62.
100. Stadnicka A, Stekiel TA, Bosnjak ZJ, Kampine JP. Inhibition by enflurane of baroreflex mediated mesenteric venoconstriction in the rabbit ileum. Anesthesiology, 1993;78:928-936.
101. Vodanovic S, Turner LA, Hoffmann RG, Kampine JP, Bosnjak ZJ. Transient negative dromotropic effects of catecholamines on canine Purkinje fibers exposed to halothane and isoflurane. Anesth Analg, 1993;76:592-597.
102. Turner LA, Polic S, Hoffmann RG, Kampine JP, Bosnjak ZJ. Actions of volatile anesthetics on ischemic and nonischemic Purkinje fibers in the urrent i canine heart: Conduction, regional refractoriness and re-entry. Anesth Analg, 1993;76:718-725.
103. Turner LA, Polic S, Hoffmann RG, Kampine JP, Bosnjak ZJ. Actions of volatile anesthetics on ischemic and nonischemic Purkinje fibers in the urrent i canine heart: Regional action potential characteristics. Anesth Analg, 1993;76:726-733.
104. Boban M, Atlee JL, Vicenzi MN, Kampine JP, Bosnjak ZJ. Anesthetics and automaticity in latent pacemaker fibers. IV. Effects of isoflurane and epinephrine or norepinephrine on automaticity of dominant and subsidiary atrial pacemakers in the canine heart. Anesthesiology, 1993;79:555-562.
105. Stowe DF, Boban M, Kampine JP, Bosnjak ZJ. Reperfusion with adenosine and nitroprusside improves preservation of isolated guinea pig hearts after 22 hours of cold perfusion with 2,3 butanedione monoxime. J Cardiovasc Pharmacol, 1993;21:578-586.
106. Woehlck HJ, Vicenzi MN, Bosnjak ZJ, Atlee JL. Anesthetics and automaticity of dominant and latent pacemakers in chronically instrumented dogs. I. Methodology, Conscious state and halothane anesthesia: Comparison with and without muscarinic blockade during exposure to epinephrine. Anesthesiology, 1993;79:1304-1315.
107. Bosnjak ZJ. Ion channels in vascular smooth muscle: Physiology and Pharmacology. Anesthesiology, 1993;79:1392-1401.
108. Vicenzi MN, Woehlck HJ, Bosnjak ZJ, Atlee JL. Anesthetics and automaticity of dominant and latent pacemakers in chronically instrumented dogs. II. Effects of enflurane and isoflurane during exposure to epinephrine with and without muscarinic blockade. Anesthesiology, 1993;79:1316-1323.
109. Hogan QH, Stadnicka A, Stekiel TA, Bosnjak ZJ, Kampine JP. Effects of epidural and systemic lidocaine on sympathetic activity and mesenteric circulation in rabbits. Anesthesiology, 1993;79:1250-1260.
110. Boban M, Stowe DF, Gross GJ, Pieper GM, Kampine JP, Bosnjak ZJ. Potassium channel openers attenuate atrioventricular block by bupivacaine in isolated hearts. Anesth Analg, 1993;76:1259-1265.
111. Stowe DF, Sprung J, Kampine JP, Turner LA, Bosnjak ZJ. Differential effects of halothane and isoflurane on contractile force and calcium transients in cardiac Purkinje fibers. Anesthesiology, 1994;80:1360-1368.
112. Buljubasic N, Marijic J, Kampine JP, Bosnjak ZJ. Calcium-sensitive potassium current in isolated coronary smooth muscle cells. Can J Physiol Pharmacol, 1994;72:189-198.
113. Lee JG, Hudetz AG, Smith JJ, Hillard CJ, Bosnjak ZJ, Kampine JP. The effects of halothane and isoflurane on cerebrocortical microcirculation and autoregulation as assessed by Laser-Doppler flowmetry. Anesth Analg, 1994;79:58-65.
114. Mazzeo AJ, Cheng EY, Stadnicka A, Bosnjak ZJ, Coon RL, Kampine JP. Topographical differences in the direct effects of isoflurane on airway smooth muscle. Anesth Analg, 1994;78:948-954.
115. Stowe DF, Boban M, Graf BM, Kampine JP, Bosnjak ZJ. Contraction uncoupling with butanedione monoxime versus low calcium or high potassium solutions on flow and contractile function of isolated hearts after prolonged hypothermic perfusion in guinea pig. Circulation, 1994;89:2412-2420.
116. Stowe DF, Boban M, Palmisano BW, Kampine JP, Bosnjak ZJ. Coronary flow response to vasodilators in isolated hearts cold perfused for one day with butanedione monoxime. Endothelium, 1994;2:87-98.
117. Graf BM, Boban M, Stowe DF, Kampine JP, Bosnjak ZJ. Lack of stereospecific effects of isoflurane and desflurane isomers in isolated guinea pig hearts. Anesthesiology, 1994;81:129-136.
118. Kenny D, Coughlan MG, Kampine JP, Montgomery RR, Bosnjak ZJ, Warltier DC. Cultured endothelial cells restore vasodilator responses to coronary arteries with impaired endothelial function and alter the response to a nitric oxide donor. Pharmacology, 1994;49:249-256.
119. Palmisano BW, Mehner RW, Stowe DF, Bosnjak ZJ, Kampine JP. Direct myocardial effects of halothane and isoflurane: Comparison between adult and infant rabbits. Anesthesiology, 1994;81:718-729.
120. Sprung J, Stowe DF, Kampine JP, Bosnjak ZJ. Hypothermia modifies anesthetic effect on contractile force and calcium transients in canine Purkinje fibers. Am J Physiol, 1994;267(H36):H725-H733.
121. Hogan QH, Stadnicka A, Stekiel TA, Bosnjak ZJ, Kampine JP. Mechanism of mesenteric venodilatation during epidural anesthesia in rabbits. Anesthesiology, 1994;81:939-945.
122. Tudoric N, Coon RL, Bosnjak ZJ. Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. Int Arch Allergy Immunol, 1994;103:286-292.
123. Tudoric N, Coon RL, Bosnjak ZJ. Phosphoramidon modulates effects of the 5-lipoxygenase inhibition on anaphylactic contraction of the guinea pig trachea. Int Arch Allergy Immunol, 1994;103:293-297.
124. Arimura H, Hoka S, Bosnjak ZJ, Kampine JP. Alteration of vascular capacitance and blood flow distribution during halothane anesthesia. J Anesthesia (Japan), 1994;8:467-471.
125. Tudoric N, Coon RL, Bosnjak ZJ. Inhibition of neural endopeptidase potentiates compound 48/80-induced constriction of guinea-pig tracheal smooth muscle. Pulmonary Pharmacol, 1994;7:343-347.
126. Lee JG, Smith JJ, Hudetz AG, Hillard CJ, Bosnjak ZJ, Kampine JP. Laser-Doppler measurement of the effects of halothane and isoflurane on the cerebrovascular CO2 response in the rat. Anesth Analg, 1995;80:696-702.
127. Turner LA, Vodanovic S, Hoffmann RG, Kampine JP, Bosnjak ZJ. A subtype of 1 mediates depression of conduction in Purkinje fibers exposed to halothane. Anesthesiology, 1995;82:1438-1446.
128. Palmisano BW, Mehner RW, Baker JE, Stowe DF, Bosnjak ZJ, Kampine JP. Direct effects of halothane and isoflurane in infant rabbit hearts with right ventricular hypertrophy secondary to chronic hypoxemia. Anesth Analg, 1995;80:1122-1128.
129. Rooney J, Marijic J, Strommel KA, Bosnjak ZJ, Aggarwal A, Kampine JP, Stowe DF. Additive cardiac depression by volatile anesthetics in isolated hearts after chronic amiodarone treatment. Anesth Analg, 1995;80:917-924.
130. Vicenzi MN, Woehlck HJ, Bajic J, Sokolyk S, Bosnjak ZJ Atlee JL. Anesthetics and automaticity of dominant and latent pacemakers in chronically instrumented dogs. III. Automaticity after SA node excision. Anesthesiology, 1995;82:469-478.
131. Eskinder H, Gebremedhin D, Lee JG, Rusch NJ, Kampine JP Bosnjak ZJ. Halothane and isoflurane decrease the open state probability of K+ channels in dog cerebral arterial muscle cells. Anesthesiology, 1995;82:479-490.
132. Boban N, McCallum JB, Schedewie HK, Boban M, Kampine JP, Bosnjak ZJ. Direct comparative effects of isoflurane and desflurane on sympathetic ganglionic transmission. Anesth Analg, 1995;80:127-134.
133. Hudetz AG, Smith JJ, Lee JG, Bosnjak ZJ, Kampine JP. Modification of cerebral laser-Doppler flow oscillations by halothane, PCO2 and nitric oxide synthase blockade. Am J Physiol, 1995;269(38): H114-H120.
134. Smith JJ, Hudetz AG, Bosnjak ZJ, Kampine JP. The role of nitric oxide in cerebrocortical laser Doppler flow response to halothane in the rat. J Neurosurg Anesth, 1995;7(3):187-195.
135. Graf BM, Vicenzi MN, Martin E, Bosnjak ZJ, Stowe DF. Ketamine has stereospecific effects in the isolated perfused guinea pig heart. Anesthesiology, 1995;82:1426-1437.
136. Graf BM, Vicenzi MN, Bosnjak ZJ, Stowe DF. The comparative effects of equimolar sevoflurane and isoflurane in isolated hearts. Anesth Analg, 1995;81:1026-1032.
137. Hogan QH, Stekiel TA, Stadnicka A, Bosnjak ZJ, Kampine JP. Region of epidural blockade determines sympathetic and mesenteric capacitance effects in rabbits. Anesthesiology, 1995;83:604-610.
138. Stadnicka A, Stekiel TA, Bosnjak ZJ, Kampine JP. Hypoxic contraction of isolated rabbit mesenteric veins. Contribution of endothelium and attenuation by volatile anesthetics. Anesthesiology, 1995;82:550-558.
139. Stekiel TA, Tominaga M, Stadnicka A, Bosnjak ZJ, Kampine JP. Isoflurane-mediated inhibition of the constriction of mesenteric capacitance veins and related circulatory responses to acute graded hypoxic hypoxia. Anesth Analg, 1995;80:994-1001.
140. Sprung J, Laszlo A, Turner LA, Kampine JP, Bosnjak ZJ. Effects of hypothermia, potassium and verapamil on the action potential characteristics of canine cardiac Purkinje fibers. Anesthesiology, 1995;82:713-722.
141. Woehlck HJ, Vicenzi MN, Bajic J, Sokolyk S, Bosnjak ZJ, Atlee JL. Anesthetics and automaticity of dominant and latent pacemakers in chronically instrumented dogs. IV. Dysrhythmias after sinoatrial node excision. Anesthesiology, 1995;82:1447-1455.
142. Stowe DF, Habazettl H, Graf BM, Kampine JP, Bosnjak ZJ. One day hypothermic preservation of isolated hearts with halothane improves cardiac function better than low calcium. Anesthesiology, 1995;83:1065-1077.
143. Tudoric N, Coon RL, Bosnjak ZJ. Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. Acta Anaesth Scand, 1995;39:1111-1116.
144. Habazettl H, Palmisano BW, Bosnjak ZJ, Graf BM, Stowe DF. Isotonic versus hypertonic initial hyperkalemic reperfusion after cardioplegic arrest in isolated hearts. Thorac Cardiovasc Surg, 1995;43:123-128.
145. Vicenzi MN, Woehlck HJ, Boban M, McCallum B, Atlee JL, Bosnjak ZJ. Muscarinic and ganglionic blocking properties of atropine compounds in vivo and in vitro: time dependence and heart rate effects. Can J Physiol Pharmacol, 1995;73:483-490.
146. Buljubasic N, Marijic J, Berczi V, Stowe DF, Kampine JP, Bosnjak ZJ. Differential effects of etomidate, propofol and midazolam on calcium and potassium channel current in isolated canine myocardial cells. Anesthesiology, 1996;85:1092-1099.
147. Cheng EY, Mazzeo AJ, Bosnjak ZJ, Coon RL, Kampine JP. Direct relaxant effects of intravenous anesthetics on airway smooth muscle. Anesth Analg, 1996;83:162-168.
148. Habazettl H, Palmisano BW, Graf BM, Bosnjak ZJ et al. Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine. Thorac Cardiovasc Surg 1996;111:74-84.
149. Kulier AH, Woehlck HJ, Hogan QH, Hoffmann R, Novalija E, Turner LA, Bosnjak ZJ. Epinephrine dysrhythmogenicity is not enhanced by subtoxic bupivacaine in dogs. Anesth Analg, 1996;83:62-67.
150. Hogan QH, Kulier A, Bosnjak ZJ, Kampine JP. Sympathetic and mesenteric venous responses to baroreceptor and chemoreceptor stimulation during epidural anesthesia in rabbits. Anesthesiology, 1996;85:1413-1421.
151. Habazettl H, Palmisano BW, Bosnjak ZJ, Stowe DF. Initial reperfusion with 2,3 butanedione monoxime is better than hyperkalemic reperfusion after cardioplegic arrest in isolated guinea pig hearts. Eur J Cardio-thorac Surg, 1996;10:897-904.
152. Stekiel TA, Stekiel WJ, Tominaga T, Stadnicka A, Bosnjak ZJ, Kampine JP. Effect of halothane and isoflurane on in situ diameter responses of small mesenteric veins to acute graded hypercapnia. Anesth Analg, 1996;82:349-357.
153. Mazzeo AJ, Cheng EY, Bosnjak ZJ, Coon RL, Kampine JP. Differential effects of desflurane and halothane on peripheral airway smooth muscle. Br J Anaest, 1996;76(6): 841-846.
154. Buljubasic N, Marijic J, Kampine JP, Bosnjak ZJ. Mechanisms of isoflurane- and halothane-induced decrease of single potassium channel current in isolated coronary smooth muscle cells. Can J Phys Pharm, 1997;38(2):105-112.
155. Vodanovic S, Turner LA, Kampine JP, Bosnjak ZJ. Negative dromotropic effects of epinephrine-halothane combination in canine Purkinje fibers depend on the sequence of exposure. Croatian Med J, 1997;38:13-18.
156. Stadnicka A, Kwok WM, Kampine JP, Bosnjak ZJ. Modulation of cardiac inward rectifier K(+)current by halothane and isoflurane. Am J Physiol, 1997;273(42):H324-H332.
157. Weigt HU, Kwok WM, Rehmert GC, Turner LA, Bosnjak ZJ. Voltage-dependent effects of inhalational anesthetics on cardiac sodium channel. Anesth Analg, 1997;84:285-293.
158. Graf B, Martin E, Bosnjak ZJ, Stowe DF. Stereospecific effect of bupivacaine isomers on atrioventricular conduction in the isolated perfused guinea pig heart. Anesthesiology, 1997;l86:410-419.
159. Graf B, Fisher B, Martin E, Bosnjak ZJ, Stowe DF. Differential effects of arginine vasopressin on isolated guinea pig heart function during perfusion at constant flow and constant pressure. J Cardiovasc Pharmacol, 1997;29:1-7.
160. Okamoto H, Meng W, Ma J, Ayata C, Roman RJ, Bosnjak ZJ, Kampine JP, Huang PL, Moskowitz MA, Hudetz AG. Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice. Anesthesiology, 1997;86:875-884.
161. Hogan QH, Novalija E, Kulier A, Turner LA, Bosnjak ZJ. Effect of thoracic epidural anesthesia on spontaneous postinfarction ventricular dysrhythmia in awake dogs. Regional Anesth, 1997;22(4):318-324.
162. Vodanovic S, Turner A, Hoffman R, Kampine JP, Bosnjak ZJ. Actions of phenylephrine, isoproterenol and epinephrine with halothane on endocardial conduction and activation in canine left ventricular papillary muscles. Anesthesiology, 1997;87:117-126.
163. Baker JE, Contney SJ, Gross GJ, Bosnjak ZJ. KATP channel activation in an rabbit model of chronic myocardial hypoxia. J Mol Cell Cardiol, 1997;29:845-848.
164. Graf BM, Fisher B, Stowe DF, Bosnjak ZJ, Martin E. Synthetic 8-ornithine-vasopressin, a clinically used vasoconstrictor, causes cardiac effects mainly via changes in coronary flow. Acta Anaest Scand, 1997;41(3):414-421.
165. Smith JJ, Lee JG, Hudetz AG, Hillard CJ, Bosnjak ZJ, Kampine JP. The role of nitric oxide in the cerebrovascular response to hypercapnia. Anesth Analg, 1997;84:363-369.
166. Stowe DF, Boban M, Roerig DL, Chang D, Palmisano B, Bosnjak ZJ. Effects of L-arginine and L-NAME on cardiac perfusion and function after one day cold preservation of isolated hearts. Circulation, 1997;95:1623-1634.
167. Weigt HU, Rehmert GC, Bosnjak ZJ, Kwok WM. Conformational state-dependent effects of halothane on cardiac Na+ current. Anesthesiology, 1997;87:1494-1506.
168. Weigt HU, Kwok WM, Rehmert GC, Turner LA, Bosnjak ZJ. Modulation of cardiac sodium current by alpha1-stimulation and volatile anesthetics. Anesthesiology, 1997;87:1507-1516.
169. Okamoto H, Hudetz AG, Roman RJ, Bosnjak ZJ. Kampine JP. Neuronal NOS-derived NO plays permissive role in cerebral blood flow response to hypercapnia. Am J Physiol, 1997;272:H559-H566.
170. Hogan QT, Amuzu J, Clifford P, Bosnjak ZJ, Kampine JP. Hypoxia causes apnea during epidural anesthesia in rabbits. Anesthesiology, 1998;88:761-777.
171. Lathrop DA, Contney SJ, Bosnjak ZJ, Stowe DF. Reversal of hypothermia-induced action potential lengthening by KATP channel agonist bimakalim in isolated guinea pig ventricular muscle. Gen Pharm, 1998;31:125-131.
172. Novalija E, Hogan QH, Kulier AH, Turner LA, Bosnjak ZJ. Effects of desflurane, sevoflurane and halothane on postinfarction spontaneous dysrhythmias in dogs. Acta Anaesth Scand, 1998;142:353-357.
173. McCallum JB, Boban N, Hogan QH, Schmelling WT, Kampine JP, Bosnjak ZJ. The mechanism of 2-adrenergic inhibition of sympathetic ganglionic transmission. Anesth Analg 1998;87:503-510.
174. Weigt HU, Kwok WM, Rehmert GC, Bosnjak ZJ. Sensitization of the cardiac Na channel to 1-adrenergic stimulation by inhalational anesthetics: Evidence for distinct modulatory pathways. Anesthesiology, 1998;88:125-133.
175. Fujita S, Roerig DL, Chung WW, Bosnjak ZJ, Stowe DF. Volatile anesthetics do not alter bradykinin-induced release of nitric oxide or L-citrulline in crystalloid perfused guinea pig hearts. Anesthesiology, 1998;89:421-433.
176. Yamazaki M, Stekiel TA, Bosnjak ZJ, Kampine JP, Stekiel WJ. Effects of volatile anesthetics on in situ vascular muscle transmembrane potential in resistance and capacitance blood vessels. Anesthesiology, 1998;88:1085-1095.
177. Stowe DF, Fujita S, Bosnjak ZJ. Improved contractility and coronary flow in isolated hearts after 1-day hypothermic preservation with isoflurane is not dependent on KATP channel activation. Anesthesiology, 1998;88:233-244.
178. Weigt HU, Kwok WM, Rehmert GC, Bosnjak ZJ. Sensitization of the cardiac Na channel to alpha1-adrenergic stimulation by inhalation anesthetics: evidence for distinct modulatory pathways. Anesthesiology, 1998;88(1):125-133.
179. Pagel PS, Hettrick DA, Kersten JR, Bosnjak ZJ, Warltier DC. Cardiovascular effects of verapamil enantiomer combination in conscious dogs. Eur J Pharmacol, 1998;348:213-221.
180. Takahata O, Krolikowski JG, McCallum JB, Lathrop DA, Bosnjak ZJ. Effects of the optical isomers of verapamil on electrophysiological properties of the heart in conscious dogs. Eur J Pharmacol, 1998;355:159-166.
181. Hettrick DA, Pagel PS, Kersten JR, Tessmer JP, Bosnjak ZJ, Georgieff M, Warltier DC. Cardiovascular effects of Xenon in isoflurane-anesthetized dogs with dilated cardiomyopathy. Anesthesiology, 1998;89:1166-1173.
182. Hogan QH, Stadnicka A, Bosnjak ZJ, Kampine JP. Effects of lidocaine and bupivacaine on isolated rabbit mesenteric capacitance veins. Reg Anesth and Pain Med, 1998;23(4):409-417.
183. Fujita S, Roerig DL, Bosnjak ZJ, Stowe DF. Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts. Cardiovasc Res, 1998;38:655-667.
184. Akhtar S, Mazzeo AJ, Cheng EY, Bosnjak ZJ, Kampine JP. Differential bronchodilatory effects of terbutaline, diltiazem and aminophylline in canine intraparenchymal airways. Am Crit Care Med, 1999;27:1551-1556.
185. Stekiel TA, Kokita N, Yamazaki M, Bosnjak ZJ, Kampine JP, Stekiel WJ. Effects of isoflurane on in situ vascular smooth muscle transmembrane potential in spontaneous hypertension. Anesthesiology, 1999;91:207-214.
186. Kokita N, Stekiel TA, Yamazaki M, Bosnjak ZJ, Kampine JP, Stekiel WJ. Potassium channel-mediated hyperpolarization of mesenteric vascular smooth muscle by isoflurane. Anesthesiology, 1999;90:779-788.
187. Stadnicka A, Kwok WM, Hartman HA, Bosnjak ZJ. Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channel. Anesthesiology, 1999;90:1671-1683.
188. Kulier AH, Novalija E, Hogan QH, Vicenzi M, Woehlck HJ, Bajic J, Atlee JL, Bosnjak ZJ. The effects of new antiarrhythmic E047/1 on postoperative ischemia induced arrhythmias in dogs. Anesth Analg, 1999;89:1393-1399.
189. Tominaga M, Stekiel TA, Bosnjak ZJ, Kampine JP. Contribution of carotid chemoreceptors to mesenteric venoconstriction during acute hypercapnia in rabbits. Am J Physiol, 1999;277:H2305-H2310.
190. Stadnicka A, Bosnjak ZJ, Kampine JP, Kwok WM. Modulation of cardiac inward rectifier K(+) current by halothane and isoflurane. Anesth Analg, 2000;90:824-833.
191. Hogan QH, McCallum JB, Sarantopoulos C, Aason M, Mynlieff M, Kwok WM, Bosnjak ZJ. Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons. Pain, 2000;86:43-53.
192. Ho BY, Stadnicka A, Prather PL, Buckley AR, Current LL, Bosnjak ZJ, Kwok WM. Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells. Endocrinology, 2000;141:1675-1685.
193. Kulier AH, Turner LA, Vodanovic S, Contney S, Lathrop DA, Bosnjak ZJ. Multiple agents potentiate alpha 1-adrenoceptor-induced conduction depression in canine cardiac purkinje fibers. Anesthesiology, 2000;92:1713-1721.
194. Stowe DF, Rehmert GC, Kwok WM, Weigt HU, Georgieff M, Bosnjak ZJ. Xenon does not alter cardiac function or major cation currents in isolated guinea pig hearts or myocytes. Anesthesiology, 2000;92:516-522.
195. Camara AK, Turner LA, Bosnjak ZJ. Interaction of halothane with isoproterenol and epinephrine on canine epicardial conduction velocity at normal and elevated potassium levels. Acta Anaesthesiol Scand, 2001;45(7):885-892.
196. Stekiel TA, Contney S, Kokita N, Bosnjak ZJ, Kampine JP, Stekiel WJ. Mechanisms of isoflurane-mediated hyperpolarization of vascular smooth muscle in chronically hypertensive and normotensive conditions. Anesthesiology, 2001;94:496-506.
197. Camara AKS, Begic Z, Kwok WM, Bosnjak ZJ. Differential modulation of the cardiac L- and T-type calcium currents by isoflurane. Anesthesiology, 2001;95:515-524.
198. Baker JE, Contney SJ, Singh R, Kalyanaraman B, Gross GJ, Bosnjak ZJ. Nitric oxide activates the sarcolemmal KATP channel in normaxic and chronically hypoxic hearts by a cyclic GMP dependent mechanism. J Mol Cell Cardiol, 2001;33:331-341.
199. Nicolosi AC, Kwok CS, Contney SJ, Olinger GN, Bosnjak ZJ. Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscle. Am J Physiol, 2001;280:H1122-11228.
200. Kohro S, Hogan QH, Nakae Y, Yamakage M, Bosnjak ZJ. Anesthetic effects on mitochondrial ATP-sensitive K channel. Anesthesiology, 2001;95:1435-1440.
201. Stadnicka A, Kwok WM, Warltier DC, Bosnjak ZJ. Protein tyrosine dependent modulation of cardiac sarcolemmal KATP channel by genistein and isoflurane. Anesthesiology, 2002;97:1198-1208.
202. Tonkovic-Capin M, Gross GJ, Bosnjak ZJ, Tweddell JS, Fitzpatrick CM, Baker JE. Delayed cardioprotection by isoflurane: Role of KATP channels. Am J Physiol, 2002;283:H61-H68.
203. Fujimoto K, Bosnjak ZJ, Kwok WM. Isoflurane-induced facilitation of the cardiac sarcolemmal KATP channels. Anesthesiology, 2002;97:57-65.
204. Kwok WM, Martinelli AT, Fujimoto K, Suzuki A, Stadnicka A, Bosnjak ZJ. Differential modulation of the cardiac ATP-sensitive potassium channel by isoflurane and halothane. Anesthesiology, 2002;97:50-56.
205. Suzuki A, Aizawa K, Gassmayr S, Bosnjak ZJ, Kwok WM. Biphasic effects of isoflurane on the cardiac action potential: An ionic basis for anesthetic-induced changes in cardiac electrophysiology. Anesthesiology, 2002;97:1209-1217.
206. Nakae Y, Kohro, S, Hogan QH, Bosnjak ZJ. Intracellular mechanism of mitochondrial adenosine triphosphate-sensitive potassium channel activation with isoflurane. Anesth Analg, 2003;97:1025-1032.
207. Gassmayr S, Stadnicka A, Suzuki A, Kwok WM, Bosnjak ZJ. Isoflurane sensitizes the cardiac sarcolemmal KATP channel to pinacidil. Anesthesiology, 2003;98:114-120.
208. Stadnicka A, Bosnjak ZJ. Isoflurane decreases ATP sensitivity of cardiac sarcolemmal KATP channel at reduced intracellular pH. Anesthesiology, 2003;98:396-403.
209. Nakae, Y, Kwok WM, Bosnjak ZJ, Jiang MT. Isoflurane activates rat mitochondrial ATP-sensitive K channels reconstituted in lipid bilayers. Am J Physiol, 2003;284:H1865-H1871.
210. Suzuki A, Bosnjak ZJ, Kwok WM. The effects of isoflurane on the cardiac slowly activating delayed-rectifier potassium channel in guinea pig ventricular myocytes. Anesth Analg, 2003;96(5):1308-1315.
211. Kohro S, Hogan QH, Nakae Y, Yamakage M, Bosnjak ZJ. Repeated or prolonged isoflurane exposure reduces mitochondrial oxidizing effects. Anesthesiology, 2003;98(1):275-278.
212. Novalija E, Kevin LG, Camara AK, Bosnjak ZJ, Kampine JP, Stowe DF. Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade. Anesthesiology, 2003;99(2):421-428.
213. McCallum JB. Kwok WM. Mynlieff M. Bosnjak ZJ, Hogan QH. Loss of t-type calcium current in sensory neurons of rats with neuropathic pain. Anesthesiology, 2003;98(1):209-216.
214. Stekiel TA, Bosnjak ZJ, Stekiel WJ. Effects of general anesthetics on regulation of the peripheral vasculature. Seminars in Cardiothorasic and Vascular Anesthesia, 2003;7(3):311-331.
215. An J, Stadnicka A, Kwok WM, Bosnjak ZJ. Contribution of reactive oxygen species to isoflurane-induced sensitization of cardiac sarcolemmal KATP channels to pinacidil. Anesthesiology, 2004;100:575-580.
216. Aizawa K, Turner LA, Weihrauch D, Bosnjak ZJ, Kwok WM. Protein Kinase C-epsilon primes cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane. Anesthesiology, 2004;101:381-389.
217. Kohro S, Hogan QH, Warltier DC, Bosnjak ZJ. Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. Anesth Analg, 2004;99:1316-1322.
218. Nicolosi AC, Kwok CS, Bosnjak ZJ. Antagonists of stretch-activated ion channels restore contractile function in hamster dilated cardiomyopathy. J Heart Lung Trans, 2004;23(8):1003-1007.
219. Stekiel TA, Contney S, Bosnjak ZJ, Kampine KP, Roman RJ, Stekiel WJ. Reversal of minimum alveolar concentrations of volatile anesthetics by chromosomal substitution. Anesthesiology, 2004;101:796-798.
220. Turner LA, Fujimoto K, Suzuki A, Stadnicka A, Bosnjak ZJ. The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels. Anesth Analg, 2005;100(6):1680-6.
221. Marinovic J, Bosnjak ZJ, Stadnicka A. Preconditioning by isoflurane induces lasting sensitization of the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel by protein kinase c-delta-mediated mechanism. Anesthesiology 2005;103:540-547.
222. Jamnicki-Abegg M, Weihrauch D, Pagel PS, Kersten JR, Bosnjak ZJ, Warltier DC, Bienengraeber MW. Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology 2005; 103(5):1006-1014.
223. Stekiel TA, Contney S, Bosnjak ZJ, Kampine JP, Roman RJ, Stekiel WJ. Chromosomal substitution-dependent differences in cardiovascular responses to sodium pentobarbital. Anesth Analg, 2006; 102:799-805.
224. Stadnicka A, Marinovic J, Bosnjak ZJ. Impact of in vivo preconditioning by isoflurane on sarcolemmal KATP channel in the rat heart: long-term modulation of nucleotide sensitivity during early memory phase of cardioprotection. Anesthesiology 2006;104:503-510.
225. Jiang MT, Ljubkovic M, Nakae Y, Shi Y, Kwok WM, Stowe DF, Bosnjak ZJ. Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. Am J Physiol Heart Circ Physiol. 2006;290:H1770-H1776.
226. Marinovic J, Bosnjak ZJ, Stadnicka A. Distinct roles for sarcolemmal and mitochondrial KATP channels in isoflurane-induced protection against oxidative stress. Anesthesiology 105:98-104, 2006.
227. Ljubkovic M, Marinovic J, Fuchs A, Bosnjak ZJ, Bienengraeber MW. Targeted expression of Kir6.2 in mitochondria confers protection against hypoxic stress. J Physiol. 2006 Nov 15;577(Pt 1):17-29. PMCID: PMC2000685
228. An J, Rhodes SS, Jiang MT, Bosnjak ZJ, Tian M, Stowe DF. Anesthetic preconditioning enhances calcium handling and mechanical and metabolic function elicited by Na/Ca exchange inhibition in isolated hearts. Anesthesiology, 2006;105:541-549.
229. Bosnjak Z. Personal narrative of prof. Zeljko Bosnjak, Laureate of Croatian National Decoration for Humanitarian Work. Croat Med J. 2006 Dec:47(6):805-808. PMCID: PMC2121599
230. Bosnjak ZJ, Warltier DC. Cellular Signal Transduction Pathways for Anesthetic-induced Cardioprotection. Touch Briefings, US Cardiovascular Disease 2006, June 2006;(1):93-94.
231. Bienengraeber M, Warltier DC, Bosnjak ZJ, Stadnicka A. Mechanism of Cardiac Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channel Activation by Isoflurane in a Heterologous Expression System. Anesthesiology, 2006;105:534-540.
232. Ljubkovic M, Mio Y, Marinovic J, Stadnicka A, Warltier DC, Bosnjak ZJ, Bienengraeber MW. Isoflurane preconditioning uncouples mitochondria with a memory effect and protects from calcium influx. Am J Physiol Cell Physiol. 2007, 292(5):C1583-90.
233. Stadnicka A, Marinovic J, Ljubkovic M, Bienengraeber MW, Bosnjak ZJ. Volatile anesthetic-induced preconditioning. 2007;21(2):212-9, J Anesthesia.
234. Jiang, MT, Nakae Y, Ljubkovic M, Kwok WM, Stowe DF, Bosnjak ZJ. Isoflurane Activates Human Cardiac Mitochondrial Adenosine Triphosphate-Sensitive K+ Channels Reconstituted in Lipid Bilayers. Anesth Analg, 2007; 105:926-32.
235. Stekiel TA, Weber C, Contney S, Bosnjak ZJ. Differences in cardiovascular sensitivity to propofol in a chromosome substitution rat model. 2007; 48(3):312-8, Croat Med J. PMCID: PMC2080540
236. An J, Bosnjak ZJ, Jiang MT. Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels. Anesth Analg 2007; 105:1207-13.
237. Ljubkovic M, Shi Y, Cheng Q, Bosnjak Z, Jiang, MT. Cardiac mitochondrial ATP-sensitive potassium channel is activated by nitric oxide in vitro. FEBS Letters, 2007;581(22):805-808.
238. Marinovic J, Ljubkovic M, Stadnicka A, Bosnjak ZJ, Bienengraeber MW. Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: mitochondrial connection. Am J Physiol 2008; 294:H1317-H1325.
239. Pravdic D, Sedlic F, Sepac A, Bosnjak ZJ. Anesthetic-Induced Preconditioning. Med Vjesn 2008; 40:37-43.
240. Eisenach JC, A Borgeat, ZJ Bosnjak, TJ Brennan, JR Kersten, E Kochs, JP Wiener-Kronish. 2007 in review: A dozen steps forward in Anesthesiology. Anesthesiology 2008; 108:149-55.
241. Simunovic, VJ et al. Short History of Just Mentorship and Support. Croat Med J. 2008;49:18-21. PMCID: PMC2269248
242. Mio Y, Bienengraeber MW, Marinovic J, Gutterman DC, Rakic M, Bosnjak ZJ, Stadnicka A. Age-related Attenuation of Isoflurane Preconditioning in Human Atrial Cardiomyocytes: Roles for Mitochondrial Respiration and Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channel Activity. Anesthesiology 2008;108(4):612-620. PMCID: PMC2697447
243. Eisenach JC, Borgeat A, Bosnjak ZJ, Brennan TJ, Kersten JR, Kochs E, Lerman J, Warner DS, Wiener-Kronish JP. 2008 in review: advancing medicine in anesthesiology. Anesthesiology 2008;109(6):962-72.
244. Stadnicka A, Contney SJ, Moreno C, Weihrauch D, Bosnjak ZJ, Roman RJ, Stekiel TA. Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway and chromosome 13 substituted consomic rat strains: role of large conductance Ca2+ and voltage activated potassium channels. J Pharmacol Exp Ther 2009; 330(3):727-35. PMCID: PMC2729794
245. Tampo A, Hogan CS, Sedlic F, Bosnjak ZJ, Kwok WM. Accelerated Inactivation of Cardiac L-type Calcium Channels Triggered by Anaesthetic-Induced Preconditioning. Br J Pharmacol 2009; 156:432-443. PMCID: PMC2697672
246. Mio Y, Shim YH, Richards E, Bosnjak ZJ, Pagel PS, Bienengraeber MW. Xenon preconditioning: Role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats. Anesth Analg 2009; 108:858-866. PMCID: PMC2748301
247. Sprung J, Whalen FX, MD, Comfere T, Bosnjak ZJ, Bajzer Z, Gajic O, Sarr MG, Schroeder DR, Lavonne LM, Liedl LM, Offord CP, Warner DO. Alveolar Recruitment and Uptake of Desflurane during Open Bariatric Surgery. Anesth Analg 2009;108(1):120-7.
248. Pravdic D, Sedlic F, Mio Y, Vladic N, Bienengraeber M, Bosnjak ZJ. Anesthetic-Induced Preconditioning Delays Opening of Mitochondrial Permeability Transition Pore via PKC-ε- Mediated Pathway. Anesthesiology 2009;111(2):267-274. PMCID: PMC2744603
249. Bosnjak ZJ, Sarantopoulos C. Channels of Preconditioning: Potassium Drain that Protects the Brain. Anesthesiology 2009; 110:961-3. PMCID: PMC2739679
250. Sedlic F, Pravdic D, Ljubkovic M, Marinovic J, Stadnicka A, Bosnjak Z. Differences in Production of Reactive Oxygen species and Mitochondrial Uncoupling as Events in the Preconditioning Signaling Cascade Between Desflurane and Sevoflurane. Anesth Analg 2009;109(2):405-11. PMCID: PMC2742556
251. Pravdic D, Vladic N, Bosnjak ZJ. Intracellular Ca2+ modulation during short exposure to ischemia-mimetic factors in isolated rat ventricular myocytes. Coll Antropol, 2009;33 Suppl 2:121-6.
252. Pravdic D, Mio Y, Sedlic F, Pratt PF, Bosnjak ZJ, Warltier DC, Bienengraeber M. Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion. Br J Pharmacol 2010; 160, 220-232. PMCID: PMC2874845
253. Sepac A, Richards R, Sedlic F, Weihrauch D, Warltier DC, Bosnjak ZJ, Brzezinska AK. Isoflurane induces translocation of the voltage dependent anion channel (VDAC-1) in human coronary artery endothelial cells. Under review, Anesth Analg, 2010.
254. Si-Tayeb K, Noto FK, Sepac A, Sedlic F, Bosnjak ZJ, Lough JW, Duncan SA. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Developmental Biology, 2010, 10:81. PMCID: PMC2923111
255. Sepac A, Sedlic F, Si-Tayeb K, Lough JW, Duncan SA, Bienengraeber M, Park F, Kim J, Bosnjak ZJ. Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells. Anesthesiology, 2010;113:906-16. PMCID: PMC2945423
256. Sedlic F, Sepac A, Pravdic D, Camara AKS, Bienengraeber B, Brzezinska AK, Wakatsuki T, Bosnjak ZJ. Mitochondrial Depolarization Underlies Delay in Permeability Transition by Preconditioning with Isoflurane: Roles of ROS and Ca2+. Am J Physiol Cell Physiol 299: C506-C515, 2010. PMCID: PMC2928640
257. Sedlic F, Pravdic D, Hirata N, Mio Y, Sepac A, Bosnjak ZJ, Camara AK, Wakatsuki T, Bienengraeber M. Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes. Biochim Biophys Acta, 2010;1797(10):1749-1758. PMCID: PMC2926458
258. Liang HL, Sedlic F, Bosnjak Z, and Nilakantan V. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radic Biol Med. 2010 Nov 30;49(10):1550-60.
259. Aggarwal NT, Pravdic D, McNally EM, Bosnjak ZJ, Shi NQ, Makielski JC. The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2-mutant mice. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1884-90. PMCID: PMC3006279
260. Cheng Q, Sedlic F, Pravdic D, Bosnjak ZJ, Kwok WM. Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Letters, 585:328-34, 2011. PMCID: PMC3035949
261. Hirata N, Shim YH, Pravdic D, Lohr NL, Pratt PF, Weihrauch D, Kersten JR, Warltier DC, Bosnjak ZJ, Bienengraeber M. Isoflurane differentially modulates mitochondrial ROS production via forward vs. reverse electron transport flow: Implications for preconditioning. Anesthesiology. 2011 Sep;115(3):531-40. PMCID: PMC3337729
262. Kim JH, Oh AY, Choi YM, Ku SY, Kim YY, Lee NJ, Sepac A, Bosnjak ZJ. Isoflurane decreases death of human embryonic stem cell-derived, transcriptional marker Nkx2.5(+) cardiac progenitor cells. Acta Anaesthesiol Scand. 2011 Oct;55(9):1124-31. PMCID: PMC3859137
263. Stekiel TA, Contney SJ, Roman RJ, Weber CA, Stadnicka A, Bosnjak ZJ, Greene AS, Moreno C. Pharmacogenomic strain differences in cardiovascular sensitivity to propofol. Anesthesiology. 2011 Dec;115(6):1192-200. PMCID: PMC3245982
264. Agarwal B, Camara AK, Stowe DF, Bosnjak ZJ, Dash RK. Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection. Biochim Biophys Acta. 2012 Mar;1817(3):453-65. PMCID: PMC3269543
265. Sepac A, Si-Tayeb K, Sedlic F, Barrett S, Canfield S, Duncan SA, Bosnjak ZJ, Lough JW. Comparison of cardiomyogenic potential among human ESC and iPSC lines. Cell Transplant. 2012;21(11):2523-30. PMCID: PMC3522765
266. Bosnjak ZJ, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Wells CW, Corbett JA, Bai X. Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Saf. 2012 Apr;7(2):106-19. PMCID: PMC3684944
267. Pravdic D, Vladic N, Cavar I, Bosnjak ZJ. Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes. Clin Exp Pharmacol Physiol. 2012 Sep;39(9):772-8. PMCID: PMC3430815
268. Pravdic D, Hirata N, Barber L, Sedlic F, Bosnjak ZJ, Bienengraeber M. Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria. Eur J Pharmacol. 2012 Sep 05;690(1-3):149-57. PMCID: PMC3653412
269. Canfield SG, Sepac A, Sedlic F, Muravyeva MY, Bai X, Bosnjak ZJ. Marked hyperglycemia attenuates anesthetic preconditioning in human-induced pluripotent stem cell-derived cardiomyocytes. Anesthesiology. 2012 Oct;117(4):735-44. PMCID: PMC3459588
270. Bosnjak ZJ. Developmental neurotoxicity screening using human embryonic stem cells. Exp Neurol. 2012 Sep;237(1):207-10. PMCID: PMC3418390
271. Bienengraeber M, Pellitteri-Hahn M, Hirata N, Baye TM, Bosnjak ZJ, Olivier M. Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia. Physiol Genomics. 2013 Mar 01;45(5):163-70. PMCID: PMC3615574
272. Bai X, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Zaja I, Corbett JA, Bosnjak ZJ. Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. Anesth Analg. 2013 Apr;116(4):869-80. PMCID: PMC3606677
273. Muravyeva M, Sedlic F, Dolan N, Bosnjak ZJ, Stadnicka A. Preconditioning by isoflurane elicits mitochondrial protective mechanisms independent of sarcolemmal KATP channel in mouse cardiomyocytes. J Cardiovasc Pharmacol. 2013 May;61(5):369-77. PMCID: PMC3648596
274. Bai X, Bosnjak ZJ. Emerging model in anesthetic developmental neurotoxicity: human stem cells. Int J Clin Anesthesiol. 2013 Jul;1:1002. PMCID: PMC4068347
275. Jia P, Teng J, Zou J, Fang Y, Zhang X, Bosnjak ZJ, Liang M, Ding X. miR-21 contributes to xenon-conferred amelioration of renal ischemia-reperfusion injury in mice. Anesthesiology. 2013 Sep;119(3):621-30. PMCID: PMC4428598
276. Jia P, Teng J, Zou J, Fang Y, Zhang X, Bosnjak ZJ, Liang M, Ding X. miR-21 contributes to xenon-conferred amelioration of renal ischemia–reperfusion injury in mice. Anesthesiology. 2013 Sep;119(3):621-30.
277. Bai X, Twaroski D, Bosnjak ZJ. Modeling anesthetic developmental neurotoxicity using human stem cells. Semin Cardiothorac Vasc Anesth. 2013 Dec;17(4):276-87. PMCID: PMC3830670
278. Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ, Camara AK. Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. Biochim Biophys Acta. 2014 Mar;1837(3):354-65. PMCID: PMC4084852
279. Muravyeva M, Baotic I, Bienengraeber M, Lazar J, Bosnjak ZJ, Sedlic F, Warltier DC, Kersten JR. Cardioprotection during diabetes: the role of mitochondrial DNA. Anesthesiology. 2014 Apr;120(4):870-9. PMCID: PMC3975667
280. Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ, Camara AK. Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol. 2014;5:341. PMCID: PMC4165278
281. Twaroski DM, Yan Y, Olson JM, Bosnjak ZJ, Bai X. Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons. Anesthesiology. 2014 Oct;121(4):786-800. PMCID: PMC4174986
282. Zaja I, Bai X, Liu Y, Kikuchi C, Dosenovic S, Yan Y, Canfield SG, Bosnjak ZJ. Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death. Biochem Biophys Res Commun. 2014 Oct 31;453(4):710-21. PMCID: PMC4312217
283. Kikuchi C, Bienengraeber M, Canfield S, Koopmeiner A, Schäfer R, Bosnjak ZJ, Bai X. Comparison of Cardiomyocyte Differentiation Potential Between Type 1 Diabetic Donor- and Nondiabetic Donor-Derived Induced Pluripotent Stem Cells. Cell Transplant. 2015;24(12):2491-504. PMCID: PMC4627864
284. Qiao S, Olson JM, Paterson M, Yan Y, Zaja I, Liu Y, Riess ML, Kersten JR, Liang M, Warltier DC, Bosnjak ZJ, Ge ZD. MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway. Anesthesiology. 2015 Oct;123(4):786-798. PMCID: PMC4573345
285. Twaroski DM, Yan Y, Zaja I, Clark E, Bosnjak ZJ, Bai X. Altered Mitochondrial Dynamics Contributes to Propofol-induced Cell Death in Human Stem Cell-derived Neurons. Anesthesiology. 2015 Nov;123(5):1067-83. PMCID: PMC4632973
286. Twaroski D, Bosnjak ZJ, Bai X. MicroRNAs: New Players in Anesthetic-Induced Developmental Neurotoxicity. Pharm Anal Acta. 2015;6:357. PMCID: PMC4486668
287. Baumgardt SL, Paterson M, Leucker TM, Fang J, Zhang DX, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD. Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice. Circ Heart Fail. 2016 Jan;9(1):e002424. PMCID: PMC4714787
288. Olson JM, Yan Y, Bai X, Ge ZD, Liang M, Kriegel AJ, Twaroski DM, Bosnjak ZJ. Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes. Anesthesiology. 2015 Apr;122(4):795-805. PMCID: PMC4366274
289. Bosnjak ZJ, Logan S, Liu Y, Bai X. Recent Insights Into Molecular Mechanisms of Propofol-Induced Developmental Neurotoxicity: Implications for the Protective Strategies. Anesth Analg. 2016 Nov;123(5):1286-1296. PMCID: PMC5073000
290. Wu HE, Baumgardt SL, Fang J, Paterson M, Liu Y, Du J, Shi Y, Qiao S, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD. Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy. Sci Rep. 2016 Jun 13;6:27925. PMCID: PMC4904741
291. Canfield SG, Zaja I, Godshaw B, Twaroski D, Bai X, Bosnjak ZJ. High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission. Anesth Analg. 2016 May;122(5):1269-79. PMCID: PMC5189917
292. Levy RJ, Herbstman JB, Bosnjak ZJ, Loepke AW, McGowan FX. Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children. J Neurosurg Anesthesiol. 2016 Oct;28(4):384-388. PMCID: PMC5326616
293. Liu Y, Baumgardt SL, Fang J, Shi Y, Qiao S, Bosnjak ZJ, Vásquez-Vivar J, Xia Z, Warltier DC, Kersten JR, Ge ZD. Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling. Sci Rep. 2017 Jun 08;7(1):3093. PMCID: PMC5465102
294. Sedlic F, Muravyeva MY, Sepac A, Sedlic M, Williams AM, Yang M, Bai X, Bosnjak ZJ. Targeted Modification of Mitochondrial ROS Production Converts High Glucose-Induced Cytotoxicity to Cytoprotection: Effects on Anesthetic Preconditioning. J Cell Physiol. 2017 Jan;232(1):216-24. PMCID: PMC5028252
295. Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC, 2016 BJA Neurotoxicology and Neuroplasticity Study Group. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2017 Sep 01;119(3):443-447. PMCID: PMC6172966
296. Bosnjak ZJ, Ge ZD. The application of remote ischemic conditioning in cardiac surgery. F1000Res. 2017;6:928. PMCID: PMC5482336
297. Liu Y, Yan Y, Inagaki Y, Logan S, Bosnjak ZJ, Bai X. Insufficient Astrocyte-Derived Brain-Derived Neurotrophic Factor Contributes to Propofol-Induced Neuron Death Through Akt/Glycogen Synthase Kinase 3β/Mitochondrial Fission Pathway. Anesth Analg. 2017 Jul;125(1):241-254. PMCID: PMC5484590
298. Ge ZD, Li Y, Qiao S, Bai X, Warltier DC, Kersten JR, Bosnjak ZJ, Liang M. Failure of Isoflurane Cardiac Preconditioning in Obese Type 2 Diabetic Mice Involves Aberrant Regulation of MicroRNA-21, Endothelial Nitric-oxide Synthase, and Mitochondrial Complex I. Anesthesiology. 2018 Jan;128(1):117-129. PMCID: PMC5726897
299. Liu Y, Paterson M, Baumgardt SL, Irwin MG, Xia Z, Bosnjak ZJ, Ge ZD. Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning. Cardiovasc Res. 2019 Jan 01;115(1):168-178. PMCID: PMC6302266
300. Terashvili M, Bosnjak ZJ. Stem Cell Therapies in Cardiovascular Disease. J Cardiothorac Vasc Anesth. 2019 Jan;33(1):209-222. PMCID: PMC6203676
301. Jiang C, Logan S, Yan Y, Inagaki Y, Arzua T, Ma P, Lu S, Bosnjak ZJ, Bai X. Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice. Sci Rep. 2018 Sep 21;8(1):14172. PMCID: PMC6155049
302. Pant T, Dhanasekaran A, Fang J, Bai X, Bosnjak ZJ, Liang M, Ge ZD. Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy. BMC Cardiovasc Disord. 2018 Oct 20;18(1):197. PMCID: PMC6196023
303. Pant T, Mishra MK, Bai X, Ge ZD, Bosnjak ZJ, Dhanasekaran A. Microarray analysis of long non-coding RNA and mRNA expression profiles in diabetic cardiomyopathy using human induced pluripotent stem cell-derived cardiomyocytes. Diab Vasc Dis Res. 2019 Jan;16(1):57-68.
304. Horikoshi Y, Yan Y, Terashvili M, Wells C, Horikoshi H, Fujita S, Bosnjak ZJ, Bai X. Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes. Cells. 2019 Sep 17;8(9). PMCID: PMC6769886
305. Pant T, Dhanasekaran A, Bai X, Zhao M, Thorp EB, Forbess JM, Bosnjak ZJ, Ge ZD. Genome-wide differential expression profiling of lncRNAs and mRNAs associated with early diabetic cardiomyopathy. Sci Rep. 2019 Oct 25;9(1):15345. PMCID: PMC6814824
306. Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020 May;124(5):585-593. PMCID: PMC7424895
307. Emelyanova L, Bai X, Yan Y, Bosnjak ZJ, Kress D, Warner C, Kroboth S, Rudic T, Kaushik S, Stoeckl E, Ross GR, Rizvi F, Tajik AJ, Jahangir A. Biphasic effect of metformin on human cardiac energetics. Transl Res. 2021 Mar;229:5-23. PMCID: PMC10655614
308. Twaroski D, Yan Y, Olson JM, Liang M, Bosnjak ZJ, Bai X. Analysis of MicroRNAs and their potential targets in human embryonic stem cell-derived neurons treated with the anesthetic propofol Neuromethods. 2017;128:29-42.
309. Stekiel TA, Bosnjak ZJ, Stekiel WJ. Effects of General Anesthetics on Regulation of the Peripheral Vasculature Seminars in Cardiothoracic and Vascular Anesthesia. September 2003;7(3):311-331.
310. Kokita N, Stekiel TA, Bosnjak ZJ, Kampine JP, Stekiel WJ. Direct isoflurane-mediated hyperpolarization of Vascular Smooth Muscle (VSM) independent of neural or stretch-activated mechanisms FASEB Journal. 20 March 1998;12(5).
311. Contney SJ, Baker JE, Gross GJ, Bosnjak ZJ. Nitric oxide activates K<inf>ATP</inf>channels during chronic myocardial hypoxia FASEB Journal. 20 March 1998;12(5).
312. László A, Ács N, Kampine JP, Bosnjak ZJ. Interactive effects of volatile anesthektics and verapamil on calcium homeostasis of pregnant rat myometrium FASEB Journal. 1997;11(3).
313. Novalija E, Hogan Q, Kulier A, Bosnjak ZJ. Minimal effects of thoracic anesthesia on spontaneous post-infarction ventricular dysrhythmia in awake dogs Regional Anesthesia. 1997;22(2 SUPPL.):33.
314. Fujita S, Smart SC, Bosnjak ZJ, Tseng LF, Mizoguchi H, Stowe DF. Delta enkephalin agonist, deltorphin, enhances myofibrillar Ca<sup>2+</sup> sensitivity in isolated hearts FASEB Journal. 1997;11(3).
315. Turner LA, Contney S, Bosnjak ZJ, Kampine JP. Epinephrine slows conduction in Canine Purkinje fibers exposed to the sensitizing intravenous anesthetics thiopental and propofol FASEB Journal. 1997;11(3).
316. Hogan Q, Amuzu J, Bosnjak ZJ, Kampine JP. Hypoxia during epidural anesthesia results in apnea in rabbits Regional Anesthesia. 1997;22(2 SUPPL.):2.
317. Buljubašić N, Marijić J, Kampine JP, Bošnjak ZJ. Mechanisms of isoflurane- and halothane-induced decrease of single potassium channel current in isolated coronary smooth muscle cells Croatian Medical Journal. June 1997;38(2):105-112.
318. Vodanović-Janković S, Turner LA, Kampine JP, Bošnjak ZJ. Negative dromotropic effects of epinephrine-halothane combination in canine Purkinje fibers depend on the sequence of exposure Croatian Medical Journal. March 1997;38(1):13-18.
319. Qkamoto H, Hudetz AG, Roman RJ, Bosnjak ZJ, Kampine JP. Neuronal nitric oxide plays permissive role in cerebral blood flow increase to hypercapnia FASEB Journal. 1996;10(3).
320. Turner IA, Contney S, Kulier AH, Bosnjak ZJ. RS17053 sensitive X1-adrenergic depression of conduction in canine purkinje fibers exposed to longchain acylcarnitine FASEB Journal. 1996;10(3).
321. Hogan Q, Amuzu J, Kulier A, Bosnjak Z, Kampine JP. Sympathetic activity and splanchnic vein responses to baroreceptor activation during epidural anesthesia Regional Anesthesia. 1996;21(2 SUPPL.):57.
322. Hogan Q, Amuzu J, Kulier A, Bosnjak Z, Kampine JP. Sympathetic activity and splanchnic vein responses to decreased f02 during epidural anesthesia in rabbits Regional Anesthesia. 1996;21(2 SUPPL.):58.
323. Graf BM, Vicenzi MN, Martin E, Bosnjak ZJ, Stowe DF, Riou B. Ketamine has stereospecific effects in the isolated perfused guinea pig heart Anesthesiology. 1995;82(6).
324. Bosnjak ZJ, Kampine JP. Preface Advances in Pharmacology. 1994;31(C).
325. Stowe DF, Boban M, Palmisano BW, Kampine JP, Bosnjak ZJ. Coronary Flow Response to Vasodilators in Isolated Hearts Cold Perfused for One Day with Butanedione Monoxime Endothelium. 1 January 1994;2(1):87-98.
326. Bosnjak ZJ, Warltier DC. New aspects of cardiac electrophysiology and function: effects of inhalational anaesthetics Bailliere's Clinical Anaesthesiology. December 1993;7(4):937-960.
327. Hogan O, Stadnicka A, Stekiel T, Bosnjak ZJ, Kampine JP. A new rabbit epidural anesthesia (ea) model: Hemodynamic responses to graded concentrations of epidural and systemic lidocaine Regional Anesthesia. March-April 1993;18(2):48.
328. Stadnicka A, Hogan O, Stekiel TA, Bosnjak ZJ, Kampine JP. Dose-dependent effects of lidocaine in isolated small mesenteric veins of the rabbit Regional Anesthesia. March-April 1993;18(2):89.
329. Dujic Z, Marijic J, Roerig SC, Dujic J, Kampine JP, Bosnjak ZJ. Presynaptic modulation of acetylcholine release from the cat stellate ganglion by morphine Croatian Medical Journal. 1993;34(1):33-42.
330. Hogan O, Stadnicka A, Stekiel T, Bosnjak ZJ, Kampine JP. The response of rabbit sympathetic efferent nerve activity (Sena) and mesenterio vein diameter (vd) to graded concentrations of epidural and im lidocaine Regional Anesthesia. March-April 1993;18(2):47.
331. Flynn NM, O'Toole DP, Bosnjak ZJ, Kampine JP. Halothane produces potent endothelium independent vasodilatation in canine middle cerebral arteries British Journal of Anaesthesia. 1992;69(2).
332. Dujic Z, Marijic J, Roerig DL, Kampine JP, Bosnjak ZJ. Effects of opioid analgesics on acetylcholine release and ganglionic transmission in the stellate ganglion of the cat Croatian Medical Journal. 1992;33(2-3):91-101.
333. Bosnjak ZJ. General anesthetics and cardiac function Periodicum Biologorum. 1991;93(4):509-518.
334. Schmeling WT, Bosnjak ZJ, Kampine JP. Anesthesia and the autonomic nervous system Seminars in Anesthesia. 1990;9(4):223-231.
335. Dujic Z, Bosnjak ZJ, Kampine JP. Effects of halothane (H) and sympathomimetics on the ventricular muscle action potential Federation Proceedings. 1985;44(5).
336. Stowe DF, Bosnjak ZJ, Kampine JP. Effect of epinephrine, acidosis and glucose lack on pacemaker activity of paired adult and neonatal SA nodes during hypoxia Federation Proceedings. 1985;44(3).
337. Bosnjak ZJ, Roerig DL, Seagard JL, Kampine JP. Modulation of acetylcholine release from the stellate ganglion by morphine and fentanyl Federation Proceedings. 1985;44(5).
338. Stowe DF, Bosnjak ZJ, Kampine JP. Effects of hypoxia and hypercapnia on cardiac pacemaker activity of adult and neonatal guinea pigs Federation Proceedings. 1984;43(4).
339. Bosnjak ZJ, Dujic Z, Kampine JP. Interaction between verapamil and halothane on calcium transients, transmembrane potentials and papillary muscle tension Federation Proceedings. 1984;43(4).
340. Turner LA, Bosnjak ZJ, Kampine JP. Electrophysiologic effects of halothane on Purkinje fibers from normal and infarcted canine hearts Federation Proceedings. 1984;43(4).
341. Seagard JL, Hopp FA, Bosnjak ZJ, Kampine JP. Mechanism of baroreceptor sensitization due to halothane Federation Proceedings. 1982;41(5).
342. Bosnjak ZJ, Kampine JM, Turner LA, Kampine JP. Effects of halothane, enflurane and isoflurane on the refractory period of the ventricular muscle cell Federation Proceedings. 1982;41(4).
343. Bosnjak ZJ, Kampine JP. Effects of halothane on ganglionic transmission Anesthesiology. 1981;55(3 Suppl.).
344. Bosnjak ZJ, Kampine JP. Halothane and sympathetic ganglionic transmission Federation Proceedings. 1981;40(3 I).
345. Kampine JP, Bosnjak ZJ, Turner LA. Effects of halothane on SA node - role of calcium Anesthesiology. 1981;55(3 Suppl.).
346. Merlos JR, Bosnjak ZJ, Purtock RV. Halothane and enflurane effects on SA node cells Anesthesiology. 1980;53(3 SUPPL.).
347. Palmer SK, Bosnjak ZJ, Hopp FA, Kampine JP. Local anesthetic blockade of canine A- and C-fibers Anesthesiology. 1980;53(3 SUPPL.).
348. Bachhuber SR, Seagard JL, Bosnjak ZJ. Halothane effect on coronary occlusion reflexes in the dog Anesthesiology. 1979;51(3 SUPPL).
349. Bosnjak ZJ, Seagard JL, Kampine JP. The effect of nitroglycerin on excitation of unmyelinated afferent cardiac sympathetic nerves during myocardial ischemia Physiologist. 1979;22(4):12.
350. Bosnjak ZJ, Seagard JL, Bamrah VS, Kampine JP. The effect of nitroglycerin on excitation of afferent cardiac sympathetic nerves during myocardial ischemia Physiologist. 1978;21(4):11.
351. Bosnjak ZJ, Bamrah VS, Seagard JL. Propranolol, verapamil, and segmental ventricular function in experimental acute coronary occlusion in dogs Federation Proceedings. 1977;36(3).
352. Pant T, Dhanasekaran A, Zhao M, Thorp EB, Forbess JM, Bosnjak ZJ, Benjamin IJ, Ge ZD. Identification and analysis of circulating long non-coding RNAs with high significance in diabetic cardiomyopathy. Sci Rep. 2021 Jan 28;11(1):2571. PMCID: PMC7843621
353. Pant T, DiStefano JK, Logan S, Bosnjak ZJ. Emerging Role of Long Noncoding RNAs in Perioperative Neurocognitive Disorders and Anesthetic-Induced Developmental Neurotoxicity. Anesth Analg. 2021 Jun 01;132(6):1614-1625. PMCID: PMC8154629
354. Perry TR, Roberts ML, Sunkara B, Maddula R, McLeish T, Gomez J, Lucas J, Rayan D, Patel S, Liang M, Bosnjak ZJ, Brown SA. Modeling Precision Cardio-Oncology: Using Human-Induced Pluripotent Stem Cells for Risk Stratification and Prevention. Curr Oncol Rep. 2021 May 03;23(7):77. PMCID: PMC8088904
355. Pant T, Juric M, Bosnjak ZJ, Dhanasekaran A. Recent Insight on the Non-coding RNAs in Mesenchymal Stem Cell-Derived Exosomes: Regulatory and Therapeutic Role in Regenerative Medicine and Tissue Engineering. Front Cardiovasc Med. 2021;8:737512. PMCID: PMC8517144
356. Sepac A, Bosnjak ZJ, Seiwerth S, Sikiric S, Dzombeta TR, Kulic A, Karsaj JM, Sedlic F. Human C2a and C6a iPSC lines and H9 ESC line have less efficient cardiomyogenesis than H1 ESC line: Beating enhances cardiac differentiation. Int J Dev Biol. 2021;65(10-11-12):537-543.
357. Liu X, Chu H, Ji Y, Bosnjak Z, Ao H, Li T. Which BMI for Diabetes Patients is Better? From the View of the Adipose Tissue Macrophage-Derived Exosome. Diabetes Metab Syndr Obes. 2022;15:141-153. PMCID: PMC8763208
358. Pant T, Jiang C, Yan Y, Schultz B, Laws D, Logan S, Bedrat A, Juric M, Berens RJ, Taylor SP, Henry AM, Mohiuddin A, Bosnjak ZJ, Bai X. Integrated 3D human cerebral organoids and paediatric patient serum analysis reveals mechanisms and biomarkers of anaesthetic-induced neurotoxicity. Br J Anaesth. 2026 Mar;136(3):915-932. PMCID: PMC12718073
359. Solomon AD, Dabral S, Brajesh RG, Day BW, Juric M, Zielonka J, Bosnjak ZJ, Pant T. Understanding the Mechanisms of Chemotherapy-Related Cardiotoxicity Employing hiPSC-Derived Cardiomyocyte Models for Drug Screening and the Identification of Genetic and Epigenetic Variants. Int J Mol Sci. 2025 Apr 23;26(9). PMCID: PMC12071959
360. Baumgardt SL, Fang J, Fu X, Liu Y, Xia Z, Zhao M, Chen L, Mishra R, Gunasekaran M, Saha P, Forbess JM, Bosnjak ZJ, Camara AKS, Kersten JR, Thorp EB, Kaushal S, Ge ZD. Genetic deletion or pharmacologic inhibition of histone deacetylase 6 protects the heart against ischaemia/reperfusion injury by limiting tumour necrosis factor alpha-induced mitochondrial injury in experimental diabetes. Cardiovasc Res. 2024 Oct 14;120(12):1456-1471. PMCID: PMC11472425
361. Pant T, Uche N, Juric M, Bosnjak ZJ. Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes. Antioxidants (Basel). 2023 Apr 07;12(4). PMCID: PMC10135521
362. Pant T, Uche N, Juric M, Bosnjak ZJ. Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes. Antioxidants (Basel). 2023 Apr 07;12(4). PMCID: PMC10135521
363. Baumgardt SL, Fang J, Fu X, Liu Y, Xia Z, Zhao M, Chen L, Mishra R, Gunasekaran M, Saha P, Forbess JM, Bosnjak ZJ, Camara AK, Kersten JR, Thorp E, Kaushal S, Ge ZD. Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts. bioRxiv. 2023 Feb 22. PMCID: PMC9980088
364. Pant T, Juric M, Bosnjak ZJ. Recent insights into Cannabinoids: Functions, mechanisms, clinical trials, and technological advancements in cancer and neurological diseases Phytopharmaceuticals and Biotechnology of Herbal Plants. 28 December 2022:225-237.

Books, Chapters, and Reviews
1. Seagard JL, Bosnjak ZJ, Hopp FA, Kotrly KJ, Ebert TJ, Kampine JP. Cardiovascular effects of general anesthesia. In: Effects of Anesthesia. Waverly Press, Inc, Baltimore & Easton, 1985;149-178.
2. Bosnjak ZJ, Hoka S, Turner LA, Kampine JP. Cardiac protection by halothane following ischemia and calcium paradox. In: Cell Calcium Metabolism: Physiology, Biochemistry, Pharmacology and Clinical Applications. New York, Plenum Press, 1989;612:593-601.
3. Schmeling WT, Bosnjak ZJ, Kampine JP. Anesthesia and the autonomic nervous system. In: Seminars in Anesthesia, Anesthesia and the Circulation I, Ed: RL Katz, W.B. Saunders Company, 1990;9(4):223-231.
4. Bosnjak ZJ. Cardiac effects of anesthetics. In: Mechanisms of Anesthetic Action in Skeletal, Cardiac and Smooth Muscle. Blanck TJJ, Wheeler DM (eds.): New York, Plenum Press, 1991;91-96.
5. Bosnjak ZJ. Effects of volatile anesthetics on the intracellular calcium transient and calcium current in cardiac muscle cells. In: Mechanisms of Anesthetic Action in Skeletal, Cardiac and Smooth Muscle. Blanck TJJ, Wheeler DM (eds.): New York, Plenum Press, 1991;97-107.
6. Flynn NM, Buljubasic N, Bosnjak ZJ, Kampine JP. Cerebral vascular responses to anesthetics. In: Mechanisms of Anesthetic Action in Skeletal, Cardiac and Smooth Muscle. Blanck TJJ, Wheeler DM (eds.): New York, Plenum Press, 1991;237-246.
7. Turner LA and Bosnjak ZJ. Autonomic and anesthetic modulation of cardiac conduction and dysrhythmias. In: Cardiac Electrophysiology. Considerations for Cardiac Anesthesia. Ch 2, Ed: C. Lynch. Philadelphia, Lippincott Co, 1993;53-84.
8. Bosnjak ZJ and Warltier DC. New aspects of cardiac electrophysiology and function: effects of inhalational anaesthetics. In: Inhalation Anaesthesia. Ch 6, Conzen P, Peter K (eds.): Bailliere's Clinical Anaesthesiology, London, Bailliere Tindall Ltd, 1993;7(4):937-960.
9. Turner LA, Vodanovic S, Bosnjak ZJ. Interaction of anesthetics and catecholamines on conduction in the canine His-Purkinje system. In: Anesthesia and Cardiovascular Disease, Bosnjak ZJ, Kampine JP (eds.): San Diego, Academic Press, 1994;167-184.
10. Atlee JL, Vicenzi MN, Woehlck HJ, Bosnjak ZJ. Anesthetics, catecholamines and ouabain on automaticity of primary and secondary pacemakers. In: Anesthesia and Cardiovascular Disease, Bosnjak ZJ, Kampine JP (eds.): San Diego, Academic Press, 1994;185-206
11. Buljubasic N, Marijic J, Bosnjak ZJ. Potassium channel current and coronary vasodilatation by volatile anesthetics. In: Anesthesia and Cardiovascular Disease, Bosnjak ZJ, Kampine JP (eds.): San Diego, Academic Press, 1994;235-252.
12. Stekiel TA, Bell LB, Bosnjak ZJ, Kampine JP. Effect of isoflurane on regulation of capacitance vessels under normotensive and chronically hypertensive conditions. In, Anesthesia and Cardiovascular Disease, Bosnjak ZJ, Kampine JP (eds.): San Diego, Academic Press, 1994;409-430.
13. McCallum JB, Stekiel TA, Stadnicka A, Bosnjak ZJ, Kampine JP. The effect of volatile anesthetics on baroreflex control of mesenteric venous capacitance. In: Anesthesia and CardiovascularDisease, Bosnjak ZJ, Kampine JP (eds.): San Diego, Academic Press, 1994;431-448.
14. Hudetz A, Lee JG, Smith JJ, Bosnjak ZJ, Kampine JP. Effects of volatile anesthetics on cerebrocortical laser-Doppler flow: hyperemia, autoregulation, CO2 response, flow oscillations and the role of nitric oxide. In: Anesthesia and Cardiovascular Disease, Bosnjak ZJ, Kampine JP (eds.): San Diego, Academic Press, 1994;577-594.
15. Bosnjak ZJ and Kampine JP. Physiology of the heart. In: Cardiac Anesthesia. Chapter 1, Estafanous FC, Barash PG, Reves JG (eds): Philadelphia, JB Lippincott Co, 1994;3-19.
16. Bosnjak ZJ and Lynch C. Cardiac Electrophysiology - Considerations for cardiac anesthesia. In: Anesthesia: Biologic Foundations, Biebuyck JF, Lynch C, Maze M, Saidman LJ, Yaksh TL, Zapol WM (eds.): New York, Raven Press, 1997;65:1001-1040.
17. Stekiel W, Stekiel T, Bosnjak ZJ. The peripheral vasculature: Control and anesthetic action. In: Anesthesia: Biologic Foundations, Biebuyck JF, Lynch C, Maze M, Saidman LJ, Yaksh TL, Zapol WM (eds.): New York, Raven Press, 1997;68:1135-1168.
18. Bosnjak ZJ, Kwok WM, Pancrazio JJ. Potassium channels. In: Anesthesia: Biologic Foundations, Biebuyck JF, Lynch C, Maze M, Saidman LJ, Yaksh TL, Zapol WM (eds.): 1997; New York, Raven Press.
19. Bosnjak ZJ. Anesthetic-Induced Cardiac Preconditioning. In: Molecular and Basic Mechanisms of Anesthesia, BW Urban, M Barann (eds.): Germany, Pabst Science Publishers, 2002;184-189.
20. Sedlic F, Sepac A, Muravyeva M, Bosnjak ZJ. Cardioprotection by Volatile Anesthetics: from Bench to Bedside and Back. Acta Anaesthesiologica Croatica 8(1):19-26, 2011.

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