Medical College of Wisconsin
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Aaron David Mickle PhD

Aaron David Mickle PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0002-6454-8038

Member of the Cardiovascular Research Center


I am willing to collaborate on research projects.

View Curriculum Vitae

Publications (37)

  • Contractions of ex-vivo mouse bladder driven by activation of channelrhodopsin-2 expressed in urothelial cells. (Alom F, Ratcliff KJ, Talluri B, Mickle AD) Sci Rep 2025 Oct 03;15(1):34617 PMID: 41044141 PMCID: PMC12494989 SCOPUS ID: 2-s2.0-105017715822 10/04/2025    
  • Local urothelial cell-driven detrusor contractions. (Alom F, Ratcliff KJ, Mickle AD) bioRxiv 2025 Feb 01 PMID: 39974977 PMCID: PMC11838309 02/20/2025    
  • Liquid-based encapsulation for implantable bioelectronics across broad pH environments. (Sun H, Xue X, Robilotto GL, Zhang X, Son C, Chen X, Cao Y, Nan K, Yang Y, Fennell G, Jung J, Song Y, Li H, Lu SH, Liu Y, Li Y, Zhang W, He J, Wang X, Li Y, Mickle AD, Zhang Y) Nat Commun 2025 Jan 25;16(1):1019 PMID: 39863617 PMCID: PMC11762702 SCOPUS ID: 2-s2.0-85216997873 01/26/2025       20 Citations
  • Role of local angiotensin II signaling in bladder function. (Anderson HA, Robilotto GL, Mickle AD) Am J Physiol Renal Physiol 2024 Nov 01;327(5):F726-F738 PMID: 39265080 PMCID: PMC11563647 SCOPUS ID: 2-s2.0-85207596708 09/12/2024    
  • Acute ampakines increase voiding function and coordination in a rat model of SCI. (Rana S, Alom F, Martinez RC, Fuller DD, Mickle AD) Elife 2024 Mar 07;12 PMID: 38451184 PMCID: PMC10962400 SCOPUS ID: 2-s2.0-85187207646 03/07/2024       4 Citations
  • Hypertension and urologic chronic pelvic pain syndrome: An analysis of MAPP-I data. (Conic RRZ, Vasilopoulos T, Devulapally K, Przkora R, Dubin A, Sibille KT, Mickle AD) BMC Urol 2024 Jan 28;24(1):21 PMID: 38281923 PMCID: PMC10822153 SCOPUS ID: 2-s2.0-85183341759 01/29/2024       5 Citations
  • Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing. (Robilotto GL, Yang OJ, Alom F, Johnson RD, Mickle AD) Am J Physiol Renal Physiol 2023 Aug 01;325(2):F150-F163 PMID: 37318991 SCOPUS ID: 2-s2.0-85164303227 06/15/2023       13 Citations
  • Acute ampakines increase voiding function and coordination in a rat model of SCI. (Rana S, Alom F, Martinez RC, Fuller DD, Mickle AD) bioRxiv 2023 Nov 17 PMID: 37293023 PMCID: PMC10245998 06/09/2023    
  • Evaluating the transduction efficiency of systemically delivered AAV vectors in the rat nervous system. (Yang OJ, Robilotto GL, Alom F, Alemán K, Devulapally K, Morris A, Mickle AD) Front Neurosci 2023;17:1001007 PMID: 36755734 PMCID: PMC9899837 SCOPUS ID: 2-s2.0-85147436634 02/10/2023       18 Citations
  • Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1. (Robilotto GL, Mohapatra DP, Shepherd AJ, Mickle AD) Eur J Pain 2022 Oct;26(9):1967-1978 PMID: 35900227 PMCID: PMC9483845 SCOPUS ID: 2-s2.0-85135524078 07/29/2022       14 Citations
  • Open source timed pressure control hardware and software for delivery of air mediated distensions in animal models. (Patel T, Hendren J, Lee N, Mickle AD) HardwareX 2022 Apr;11:e00271 PMID: 35509929 PMCID: PMC9058729 SCOPUS ID: 2-s2.0-85124207731 05/06/2022    
  • Characterization of a method to study urodynamics and bladder nociception in male and female mice. (Srivastava P, Lai HH, Mickle AD) Low Urin Tract Symptoms 2021 Apr;13(2):319-324 PMID: 33202486 PMCID: PMC8474011 SCOPUS ID: 2-s2.0-85096720870 11/18/2020       3 Citations
  • Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. (Zhang Y, Mickle AD, Gutruf P, McIlvried LA, Guo H, Wu Y, Golden JP, Xue Y, Grajales-Reyes JG, Wang X, Krishnan S, Xie Y, Peng D, Su CJ, Zhang F, Reeder JT, Vogt SK, Huang Y, Rogers JA, Gereau RW 4th) Sci Adv 2019 Jul;5(7):eaaw5296 PMID: 31281895 PMCID: PMC6611690 SCOPUS ID: 2-s2.0-85068588571 07/10/2019       164 Citations
  • A wireless closed-loop system for optogenetic peripheral neuromodulation. (Mickle AD, Won SM, Noh KN, Yoon J, Meacham KW, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Payne MA, Zhang J, Jang H, Li Y, Lai HH, Huang Y, Park SI, Gereau RW 4th, Rogers JA) Nature 2019 Jan;565(7739):361-365 PMID: 30602791 PMCID: PMC6336505 SCOPUS ID: 2-s2.0-85060148196 01/04/2019       456 Citations
  • A bright future? Optogenetics in the periphery for pain research and therapy. (Mickle AD, Gereau RW 4th) Pain 2018 Sep;159 Suppl 1(Suppl 1):S65-S73 PMID: 30113949 PMCID: PMC6097536 SCOPUS ID: 2-s2.0-85064486300 08/17/2018       25 Citations
  • Macrophage angiotensin II type 2 receptor triggers neuropathic pain. (Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW 4th, Mohapatra DP) Proc Natl Acad Sci U S A 2018 Aug 21;115(34):E8057-E8066 PMID: 30082378 PMCID: PMC6112686 SCOPUS ID: 2-s2.0-85051790113 08/08/2018       114 Citations
  • Natural Wax for Transient Electronics (Won SM, Koo J, Crawford KE, Mickle AD, Xue Y, Min S, McIlvried LA, Yan Y, Kim SB, Lee SM, Kim BH, Jang H, MacEwan MR, Huang Y, Gereau RW, Rogers JA) Advanced Functional Materials 8 August 2018;28(32) SCOPUS ID: 2-s2.0-85051141234 08/08/2018       122 Citations
  • Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain. (Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP) J Neurosci 2018 Aug 08;38(32):7032-7057 PMID: 29976627 PMCID: PMC6083458 SCOPUS ID: 2-s2.0-85051586513 07/07/2018       103 Citations
  • Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons. (Shepherd AJ, Mickle AD, McIlvried LA, Gereau RW 4th, Mohapatra DP) Eur J Pain 2018 Oct;22(9):1685-1690 PMID: 29797679 SCOPUS ID: 2-s2.0-85053414226 05/26/2018       9 Citations
  • Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity. (Shepherd AJ, Mickle AD, Kadunganattil S, Hu H, Mohapatra DP) Front Cell Neurosci 2018;12:38 PMID: 29497363 PMCID: PMC5818411 SCOPUS ID: 2-s2.0-85043586891 03/03/2018       21 Citations
  • Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics. (Noh KN, Park SI, Qazi R, Zou Z, Mickle AD, Grajales-Reyes JG, Jang KI, Gereau RW 4th, Xiao J, Rogers JA, Jeong JW) Small 2018 Jan;14(4) PMID: 29215787 PMCID: PMC5912318 SCOPUS ID: 2-s2.0-85040970185 12/08/2017       111 Citations
  • Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain. (Samineni VK, Mickle AD, Yoon J, Grajales-Reyes JG, Pullen MY, Crawford KE, Noh KN, Gereau GB, Vogt SK, Lai HH, Rogers JA, Gereau RW 4th) Sci Rep 2017 Nov 20;7(1):15865 PMID: 29158567 PMCID: PMC5696510 SCOPUS ID: 2-s2.0-85034640184 11/22/2017       49 Citations
  • Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics. (Samineni VK, Yoon J, Crawford KE, Jeong YR, McKenzie KC, Shin G, Xie Z, Sundaram SS, Li Y, Yang MY, Kim J, Wu D, Xue Y, Feng X, Huang Y, Mickle AD, Banks A, Ha JS, Golden JP, Rogers JA, Gereau RW 4th) Pain 2017 Nov;158(11):2108-2116 PMID: 28700536 PMCID: PMC5640477 SCOPUS ID: 2-s2.0-85040794230 07/13/2017       104 Citations
  • Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. (Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RW 4th, Ha JS, Bruchas MR, Rogers JA) Neuron 2017 Feb 08;93(3):509-521.e3 PMID: 28132830 PMCID: PMC5377903 SCOPUS ID: 2-s2.0-85010840004 01/31/2017       380 Citations
  • Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics. (Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW 4th, Bruchas MR, Rogers JA) Proc Natl Acad Sci U S A 2016 Dec 13;113(50):E8169-E8177 PMID: 27911798 PMCID: PMC5167187 SCOPUS ID: 2-s2.0-85006042924 12/03/2016       130 Citations
  • Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies. (Mickle AD, Shepherd AJ, Mohapatra DP) Pharmaceuticals (Basel) 2016 Nov 14;9(4) PMID: 27854251 PMCID: PMC5198047 SCOPUS ID: 2-s2.0-84997294311 11/18/2016       119 Citations
  • Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. (Mickle AD, Shepherd AJ, Loo L, Mohapatra DP) Pain 2015 Sep;156(9):1620-1636 PMID: 25970319 PMCID: PMC5070921 SCOPUS ID: 2-s2.0-84964617156 05/15/2015       25 Citations
  • Sensory TRP channels: the key transducers of nociception and pain. (Mickle AD, Shepherd AJ, Mohapatra DP) Prog Mol Biol Transl Sci 2015;131:73-118 PMID: 25744671 PMCID: PMC5903472 SCOPUS ID: 2-s2.0-84924581659 03/07/2015       139 Citations
  • NMDA receptor mediates chronic visceral pain induced by neonatal noxious somatic stimulation. (Miranda A, Mickle A, Bruckert M, Kannampalli P, Banerjee B, Sengupta JN) Eur J Pharmacol 2014 Dec 05;744:28-35 PMID: 25281204 PMCID: PMC4261000 SCOPUS ID: 2-s2.0-84918795742 10/05/2014       15 Citations
  • Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. (Borges GR, Morgan DA, Ketsawatsomkron P, Mickle AD, Thompson AP, Cassell MD, Mohapatra DP, Rahmouni K, Sigmund CD) Hypertension 2014 Sep;64(3):590-6 PMID: 24914194 PMCID: PMC4134389 SCOPUS ID: 2-s2.0-84907598119 06/11/2014       13 Citations
  • Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM). (Sengupta JN, Mickle A, Kannampalli P, Spruell R, McRorie J, Shaker R, Miranda A) Neuropharmacology 2014 Apr;79:345-58 PMID: 24334068 PMCID: PMC4321751 SCOPUS ID: 2-s2.0-84891619998 12/18/2013       19 Citations
  • Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics. (Shepherd AJ, Loo L, Gupte RP, Mickle AD, Mohapatra DP) J Neurosci 2012 Dec 05;32(49):17725-39 PMID: 23223293 PMCID: PMC3544972 SCOPUS ID: 2-s2.0-84870542038 12/12/2012       32 Citations
  • The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel. (Loo L, Shepherd AJ, Mickle AD, Lorca RA, Shutov LP, Usachev YM, Mohapatra DP) J Neurosci 2012 Aug 29;32(35):11942-55 PMID: 22933780 PMCID: PMC3461320 SCOPUS ID: 2-s2.0-84865469570 08/31/2012       42 Citations
  • Pronociceptive effect of 5-HT(1A) receptor agonist on visceral pain involves spinal N-methyl-D-aspartate (NMDA) receptor. (Mickle A, Kannampalli P, Bruckert M, Miranda A, Banerjee B, Sengupta JN) Neuroscience 2012 Sep 06;219:243-54 PMID: 22626644 PMCID: PMC3402596 SCOPUS ID: 2-s2.0-84864075446 05/26/2012       13 Citations
  • Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence. (Miranda A, Mickle A, Schmidt J, Zhang Z, Shaker R, Banerjee B, Sengupta JN) Neurogastroenterol Motil 2011 Jul;23(7):683-e281 PMID: 21592255 PMCID: PMC3117950 SCOPUS ID: 2-s2.0-79959311098 05/20/2011       34 Citations
  • Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. (Mickle A, Sood M, Zhang Z, Shahmohammadi G, Sengupta JN, Miranda A) Pain 2010 Jun;149(3):555-564 PMID: 20413219 PMCID: PMC2884285 SCOPUS ID: 2-s2.0-77952109906 04/24/2010       40 Citations
  • Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats. (Miranda A, Mickle A, Medda B, Zhang Z, Phillips RJ, Tipnis N, Powley TL, Shaker R, Sengupta JN) Neuroscience 2009 Sep 15;162(4):1299-306 PMID: 19477237 PMCID: PMC2741133 SCOPUS ID: 2-s2.0-67949124551 05/30/2009       20 Citations
    • Last update: 04/21/2026