Medical College of Wisconsin
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Antje Schaefer PhD

Antje Schaefer PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

View Curriculum Vitae

Research Experience

  • Carcinoma, Pancreatic Ductal
  • Cell Plasticity
  • Drug Screening Assays, Antitumor
  • Organoids
  • Stomach Neoplasms
  • ras Proteins
  • rho GTP-Binding Proteins

    • Publications (23)

  • Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. (Klomp JE, Diehl JN, Klomp JA, Edwards AC, Yang R, Morales AJ, Taylor KE, Drizyte-Miller K, Bryant KL, Schaefer A, Johnson JL, Huntsman EM, Yaron TM, Pierobon M, Baldelli E, Prevatte AW, Barker NK, Herring LE, Petricoin EF 3rd, Graves LM, Cantley LC, Cox AD, Der CJ, Stalnecker CA) Science 2024 Jun 07;384(6700):eadk0850 PMID: 38843329 PMCID: PMC11301400 SCOPUS ID: 2-s2.0-85195439364 06/06/2024       2 Citations
  • Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer. (Zhang F, Sahu V, Peng K, Wang Y, Li T, Bala P, Aitymbayev D, Sahgal P, Schaefer A, Der CJ, Ryeom S, Yoon S, Sethi N, Bass AJ, Zhang H) Gut 2024 Jul 11;73(8):1280-1291 PMID: 38621923 PMCID: PMC11287566 SCOPUS ID: 2-s2.0-85191367560 04/16/2024       1 Citation
  • RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling. (Schaefer A, Hodge RG, Zhang H, Hobbs GA, Dilly J, Huynh MV, Goodwin CM, Zhang F, Diehl JN, Pierobon M, Baldelli E, Javaid S, Guthrie K, Rashid NU, Petricoin EF, Cox AD, Hahn WC, Aguirre AJ, Bass AJ, Der CJ) Sci Signal 2023 Dec 19;16(816):eadg5289 PMID: 38113333 PMCID: PMC10791543 SCOPUS ID: 2-s2.0-85180383446 12/19/2023       1 Citation
  • Functional and biological heterogeneity of KRASQ61 mutations. (Huynh MV, Hobbs GA, Schaefer A, Pierobon M, Carey LM, Diehl JN, DeLiberty JM, Thurman RD, Cooke AR, Goodwin CM, Cook JH, Lin L, Waters AM, Rashid NU, Petricoin EF 3rd, Campbell SL, Haigis KM, Simeone DM, Lyssiotis CA, Cox AD, Der CJ) Sci Signal 2022 Aug 09;15(746):eabn2694 PMID: 35944066 PMCID: PMC9534304 SCOPUS ID: 2-s2.0-85135733710 08/10/2022       12 Citations
  • RHOA takes the RHOad less traveled to cancer. (Schaefer A, Der CJ) Trends Cancer 2022 Aug;8(8):655-669 PMID: 35568648 SCOPUS ID: 2-s2.0-85130338063 05/15/2022       15 Citations
  • Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma. (Javaid S, Schaefer A, Goodwin CM, Nguyen VV, Massey FL, Pierobon M, Gambrell-Sanders D, Waters AM, Lambert KN, Diehl JN, Hobbs GA, Wood KC, Petricoin EF, Der CJ, Cox AD) Mol Cancer Ther 2022 May 04;21(5):762-774 PMID: 35247914 PMCID: PMC9081222 SCOPUS ID: 2-s2.0-85129996457 03/06/2022       11 Citations
  • Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth. (Cook DR, Kang M, Martin TD, Galanko JA, Loeza GH, Trembath DG, Justilien V, Pickering KA, Vincent DF, Jarosch A, Jurmeister P, Waters AM, Hibshman PS, Campbell AD, Ford CA, Keku TO, Yeh JJ, Lee MS, Cox AD, Fields AP, Sandler RS, Sansom OJ, Sers C, Schaefer A, Der CJ) Cancer Res 2022 Jan 01;82(1):90-104 PMID: 34737214 PMCID: PMC9056178 SCOPUS ID: 2-s2.0-85122399548 11/06/2021       20 Citations
  • Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. (Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ) Cell Rep 2021 Jun 29;35(13):109291 PMID: 34192548 PMCID: PMC8340308 SCOPUS ID: 2-s2.0-85108871908 07/01/2021       14 Citations
  • RAS and RHO family GTPase mutations in cancer: twin sons of different mothers? (Hodge RG, Schaefer A, Howard SV, Der CJ) Crit Rev Biochem Mol Biol 2020 Aug;55(4):386-407 PMID: 32838579 SCOPUS ID: 2-s2.0-85089736184 08/26/2020       30 Citations
  • The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. (Arrington ME, Temple B, Schaefer A, Campbell SL) J Biol Chem 2020 Aug 21;295(34):12130-12142 PMID: 32636302 PMCID: PMC7443499 SCOPUS ID: 2-s2.0-85089797156 07/09/2020       7 Citations
  • Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers. (Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, Petricoin EF 3rd, Tran NL, Bhagwat SV, Tiu RV, Peng SB, Herring LE, Graves LM, Sers C, Wood KC, Cox AD, Der CJ) Cell Rep 2020 Jun 16;31(11):107764 PMID: 32553168 PMCID: PMC7393480 SCOPUS ID: 2-s2.0-85086391632 06/20/2020       60 Citations
  • Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. (Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ) Cancer Discov 2020 Feb;10(2):288-305 PMID: 31771969 PMCID: PMC7007383 SCOPUS ID: 2-s2.0-85079074836 11/28/2019       105 Citations
  • Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation. (Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Alphen F, Hordijk P, Stroes ESG, Strömblad S, van Rheenen J, van Buul JD) J Immunol 2018 Mar 01;200(5):1790-1801 PMID: 29386254 SCOPUS ID: 2-s2.0-85044757309 02/02/2018       25 Citations
  • Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro. (Schaefer A, van Duijn TJ, Majolee J, Burridge K, Hordijk PL) J Immunol 2017 Jun 15;198(12):4823-4836 PMID: 28484055 PMCID: PMC5510545 SCOPUS ID: 2-s2.0-85020463656 05/10/2017       15 Citations
  • A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1. (Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD) J Cell Sci 2015 Aug 15;128(16):3041-54 PMID: 26116572 SCOPUS ID: 2-s2.0-84939474806 06/28/2015       71 Citations
  • Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration. (Schaefer A, Hordijk PL) J Cell Sci 2015 Jul 01;128(13):2221-30 PMID: 26092932 SCOPUS ID: 2-s2.0-84935414352 06/21/2015       79 Citations
  • Toward understanding RhoGTPase specificity: structure, function and local activation. (Schaefer A, Reinhard NR, Hordijk PL) Small GTPases 2014;5(2):6 PMID: 25483298 PMCID: PMC4601309 SCOPUS ID: 2-s2.0-84922251368 12/09/2014       77 Citations
  • Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration. (Schaefer A, Te Riet J, Ritz K, Hoogenboezem M, Anthony EC, Mul FP, de Vries CJ, Daemen MJ, Figdor CG, van Buul JD, Hordijk PL) J Cell Sci 2014 Oct 15;127(Pt 20):4470-82 PMID: 25107367 SCOPUS ID: 2-s2.0-84917680357 08/12/2014       85 Citations
  • The human minor histocompatibility antigen 1 is a RhoGAP. (de Kreuk BJ, Schaefer A, Anthony EC, Tol S, Fernandez-Borja M, Geerts D, Pool J, Hambach L, Goulmy E, Hordijk PL) PLoS One 2013;8(9):e73962 PMID: 24086303 PMCID: PMC3781157 SCOPUS ID: 2-s2.0-84884522965 10/03/2013       25 Citations
  • Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration. (Schaefer A, Nethe M, Hordijk PL) Biochem J 2012 Feb 15;442(1):13-25 PMID: 22280013 SCOPUS ID: 2-s2.0-84856267593 01/28/2012       40 Citations
  • Dimeric plant RhoGAPs are regulated by its CRIB effector motif to stimulate a sequential GTP hydrolysis. (Schaefer A, Miertzschke M, Berken A, Wittinghofer A) J Mol Biol 2011 Aug 26;411(4):808-22 PMID: 21723292 SCOPUS ID: 2-s2.0-80051665477 07/05/2011       15 Citations
  • The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins. (Schaefer A, Höhner K, Berken A, Wittinghofer A) Biopolymers 2011 Jun;95(6):420-33 PMID: 21294109 SCOPUS ID: 2-s2.0-80051666898 02/05/2011       14 Citations
  • Rho proteins of plants--functional cycle and regulation of cytoskeletal dynamics. (Mucha E, Fricke I, Schaefer A, Wittinghofer A, Berken A) Eur J Cell Biol 2011 Nov;90(11):934-43 PMID: 21277045 SCOPUS ID: 2-s2.0-79959926844 02/01/2011       45 Citations
    • Last update: 10/04/2024