Medical College of Wisconsin
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Aoy Tomita Mitchell PhD

Aoy Tomita Mitchell PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Congenital Cardiac Surgery
Program: Pediatric Cardiothoracic-Mitchell Research

Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Publications (46)

  • Novel KLHL26 variant associated with a familial case of Ebstein's anomaly and left ventricular noncompaction. (Samudrala SSK, North LM, Stamm KD, Earing MG, Frommelt MA, Willes R, Tripathi S, Dsouza NR, Zimmermann MT, Mahnke DK, Liang HL, Lund M, Lin CW, Geddes GC, Mitchell ME, Tomita-Mitchell A) Mol Genet Genomic Med 2020 04;8(4):e1152 PMID: 31985165 PMCID: PMC7196453 SCOPUS ID: 2-s2.0-85078673520 01/28/2020    
  • Donor fraction cell-free DNA and rejection in adult and pediatric heart transplantation. (Richmond ME, Zangwill SD, Kindel SJ, Deshpande SR, Schroder JN, Bichell DP, Knecht KR, Mahle WT, Wigger MA, Gaglianello NA, Pahl E, Simpson PM, Dasgupta M, North PE, Hidestrand M, Tomita-Mitchell A, Mitchell ME) J Heart Lung Transplant 2020 May;39(5):454-463 PMID: 31983667 SCOPUS ID: 2-s2.0-85078178592 01/28/2020       2 Citations
  • Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability. (North PE, Ziegler E, Mahnke DK, Stamm KD, Thomm A, Daft P, Goetsch M, Liang HL, Baker MA, Vepraskas A, Rosenau C, Dasgupta M, Simpson P, Mitchell ME, Tomita-Mitchell A) PLoS One 2020;15(1):e0227385 PMID: 31929557 PMCID: PMC6957190 SCOPUS ID: 2-s2.0-85077765307 01/14/2020       1 Citation
  • Early changes in cell-free DNA levels in newly transplanted heart transplant patients. (Zangwill SD, Kindel SJ, Ragalie WS, North PE, Pollow A, Hidestrand M, Tomita-Mitchell A, Stamm KD, Mitchell ME) Pediatr Transplant 2020 02;24(1):e13622 PMID: 31825144 PMCID: PMC7065377 SCOPUS ID: 2-s2.0-85076338475 12/12/2019    
  • Effect of endomyocardial biopsy on levels of donor-specific cell-free DNA. (Zangwill SD, Stamm KD, Hidestrand M, Tomita-Mitchell A, Mitchell ME) J Heart Lung Transplant 2019 10;38(10):1118-1120 PMID: 31324442 PMCID: PMC7556715 SCOPUS ID: 2-s2.0-85072281917 07/22/2019       2 Citations
  • Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta. (LaDisa JF Jr, Tomita-Mitchell A, Stamm K, Bazan K, Mahnke DK, Goetsch MA, Wegter BJ, Gerringer JW, Repp K, Palygin O, Zietara AP, Krolikowski MM, Eddinger TJ, Alli AA, Mitchell ME) Physiol Genomics 2019 06 01;51(6):177-185 PMID: 31002586 PMCID: PMC6620646 SCOPUS ID: 2-s2.0-85066457176 04/20/2019       2 Citations
  • GSEPD: a Bioconductor package for RNA-seq gene set enrichment and projection display. (Stamm K, Tomita-Mitchell A, Bozdag S) BMC Bioinformatics 2019 Mar 06;20(1):115 PMID: 30841846 PMCID: PMC6404334 SCOPUS ID: 2-s2.0-85062495607 03/08/2019       1 Citation
  • Metakaryotic cells linked to pediatric pulmonary vein stenosis. (Kirkpatrick EC, Mitchell ME, Thilly WG, Hidestrand P, Tomita-Mitchell A, Hidestrand M, Gostjeva EV) Cardiovasc Pathol 2019 Mar - Apr;39:51-53 PMID: 30660022 SCOPUS ID: 2-s2.0-85059952993 01/20/2019       1 Citation
  • Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects. (Zhao Y, Guo T, Fiksinski A, Breetvelt E, McDonald-McGinn DM, Crowley TB, Diacou A, Schneider M, Eliez S, Swillen A, Breckpot J, Vermeesch J, Chow EWC, Gothelf D, Duijff S, Evers R, van Amelsvoort TA, van den Bree M, Owen M, Niarchou M, Bearden CE, Ornstein C, Pontillo M, Buzzanca A, Vicari S, Armando M, Murphy KC, Murphy C, Garcia-Minaur S, Philip N, Campbell L, Morey-Cañellas J, Raventos J, Rosell J, Heine-Suner D, Shprintzen RJ, Gur RE, Zackai E, Emanuel BS, Wang T, Kates WR, Bassett AS, Vorstman JAS, Morrow BE, International 22q11.2 Brain and Behavior Consortium) Am J Med Genet A 2018 10;176(10):2172-2181 PMID: 30289625 PMCID: PMC6209529 SCOPUS ID: 2-s2.0-85054522149 10/06/2018       3 Citations
  • Noninvasive Assay for Donor Fraction of Cell-Free DNA in Pediatric Heart Transplant Recipients. (Ragalie WS, Stamm K, Mahnke D, Liang HL, Simpson P, Katz R, Tomita-Mitchell A, Kindel SJ, Zangwill S, Mitchell ME) J Am Coll Cardiol 2018 06 26;71(25):2982-2983 PMID: 29929623 SCOPUS ID: 2-s2.0-85048264947 06/23/2018       7 Citations
  • Genome-Wide Association Study to Find Modifiers for Tetralogy of Fallot in the 22q11.2 Deletion Syndrome Identifies Variants in the GPR98 Locus on 5q14.3. (Guo T, Repetto GM, McDonald McGinn DM, Chung JH, Nomaru H, Campbell CL, Blonska A, Bassett AS, Chow EWC, Mlynarski EE, Swillen A, Vermeesch J, Devriendt K, Gothelf D, Carmel M, Michaelovsky E, Schneider M, Eliez S, Antonarakis SE, Coleman K, Tomita-Mitchell A, Mitchell ME, Digilio MC, Dallapiccola B, Marino B, Philip N, Busa T, Kushan-Wells L, Bearden CE, Piotrowicz M, Hawuła W, Roberts AE, Tassone F, Simon TJ, van Duin EDA, van Amelsvoort TA, Kates WR, Zackai E, Johnston HR, Cutler DJ, Agopian AJ, Goldmuntz E, Mitchell LE, Wang T, Emanuel BS, Morrow BE, International 22q11.2 Consortium/Brain and Behavior Consortium*) Circ Cardiovasc Genet 2017 Oct;10(5) PMID: 29025761 PMCID: PMC5647121 10/14/2017    
  • Impact of MYH6 variants in hypoplastic left heart syndrome. (Tomita-Mitchell A, Stamm KD, Mahnke DK, Kim MS, Hidestrand PM, Liang HL, Goetsch MA, Hidestrand M, Simpson P, Pelech AN, Tweddell JS, Benson DW, Lough JW, Mitchell ME) Physiol Genomics 2016 12 01;48(12):912-921 PMID: 27789736 PMCID: PMC5206387 SCOPUS ID: 2-s2.0-85006309110 10/30/2016       19 Citations
  • Ciliopathy variant burden and developmental delay in children with hypoplastic left heart syndrome. (Geddes GC, Stamm K, Mitchell M, Mussatto KA, Tomita-Mitchell A) Genet Med 2017 06;19(6):711-714 PMID: 27787502 SCOPUS ID: 2-s2.0-85020225756 10/28/2016       4 Citations
  • Metakaryotic cancer stem cells are constitutively resistant to X-rays and chemotherapeutic agents, but sensitive to many common drugs (Gostjeva EV, Koledova VV, Bai L, Duan KC, Kamath T, Nelson M, Agnihotri P, Moshinski DJ, Ping Wu L, Zukerberg L, Chung DC, Tsai S, Evans DB, Tomita-Mitchell A, Mitchell M, Thilly WG) Issues in Toxicology 2016;2016-January(29):196-249 SCOPUS ID: 2-s2.0-84986556373 01/01/2016    
  • Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery. (Brenner MK, Clarke S, Mahnke DK, Simpson P, Bercovitz RS, Tomita-Mitchell A, Mitchell ME, Newman DK) Pediatr Res 2016 Feb;79(2):318-24 PMID: 26492284 PMCID: PMC5114022 SCOPUS ID: 2-s2.0-84982285447 10/23/2015       14 Citations
  • Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. (Kim MS, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J) PLoS One 2015;10(2):e0118670 PMID: 25706534 PMCID: PMC4338295 SCOPUS ID: 2-s2.0-84923332744 02/24/2015       11 Citations
  • Use of cell-free fetal DNA in maternal plasma for noninvasive prenatal screening. (Wagner AJ, Mitchell ME, Tomita-Mitchell A) Clin Perinatol 2014 Dec;41(4):957-66 PMID: 25459783 SCOPUS ID: 2-s2.0-84910116657 12/03/2014       14 Citations
  • The inferred cardiogenic gene regulatory network in the mammalian heart. (Bazil JN, Stamm KD, Li X, Thiagarajan R, Nelson TJ, Tomita-Mitchell A, Beard DA) PLoS One 2014;9(6):e100842 PMID: 24971943 PMCID: PMC4074065 SCOPUS ID: 2-s2.0-84903388331 06/28/2014       9 Citations
  • Chromosomal Imbalances in Patients with Congenital Cardiac Defects: A Meta-analysis Reveals Novel Potential Critical Regions Involved in Heart Development. (Thorsson T, Russell WW, El-Kashlan N, Soemedi R, Levine J, Geisler SB, Ackley T, Tomita-Mitchell A, Rosenfeld JA, Töpf A, Tayeh M, Goodship J, Innis JW, Keavney B, Russell MW) Congenit Heart Dis 2015 May-Jun;10(3):193-208 PMID: 24720490 SCOPUS ID: 2-s2.0-84933675983 04/12/2014       18 Citations
  • Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid. (Hidestrand M, Tomita-Mitchell A, Hidestrand PM, Oliphant A, Goetsch M, Stamm K, Liang HL, Castleberry C, Benson DW, Stendahl G, Simpson PM, Berger S, Tweddell JS, Zangwill S, Mitchell ME) J Am Coll Cardiol 2014 Apr 01;63(12):1224-1226 PMID: 24140666 PMCID: PMC4988656 SCOPUS ID: 2-s2.0-84896944581 10/22/2013       41 Citations
  • Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM) J Clin Immunol 2013 Jan;33(1):30-9 PMID: 22930256 PMCID: PMC3557581 SCOPUS ID: 2-s2.0-84876429921 08/30/2012       118 Citations
  • Human gene copy number spectra analysis in congenital heart malformations. (Tomita-Mitchell A, Mahnke DK, Struble CA, Tuffnell ME, Stamm KD, Hidestrand M, Harris SE, Goetsch MA, Simpson PM, Bick DP, Broeckel U, Pelech AN, Tweddell JS, Mitchell ME) Physiol Genomics 2012 May 01;44(9):518-41 PMID: 22318994 PMCID: PMC3426426 SCOPUS ID: 2-s2.0-84862128193 02/10/2012       63 Citations
  • Influence of temperature during transportation on cell-free DNA analysis. (Hidestrand M, Stokowski R, Song K, Oliphant A, Deavers J, Goetsch M, Simpson P, Kuhlman R, Ames M, Mitchell M, Tomita-Mitchell A) Fetal Diagn Ther 2012;31(2):122-8 PMID: 22261730 SCOPUS ID: 2-s2.0-84859006623 01/21/2012       54 Citations
  • Selective analysis of cell-free DNA in maternal blood for evaluation of fetal trisomy. (Sparks AB, Wang ET, Struble CA, Barrett W, Stokowski R, McBride C, Zahn J, Lee K, Shen N, Doshi J, Sun M, Garrison J, Sandler J, Hollemon D, Pattee P, Tomita-Mitchell A, Mitchell M, Stuelpnagel J, Song K, Oliphant A) Prenat Diagn 2012 Jan;32(1):3-9 PMID: 22223233 PMCID: PMC3500507 SCOPUS ID: 2-s2.0-84857502701 01/10/2012       197 Citations
  • Exploring the environmental and genetic etiologies of congenital heart defects: the Wisconsin Pediatric Cardiac Registry. (Harris SE, Cronk C, Cassidy LD, Simpson P, Tomita-Mitchell A, Pelech AN) J Registry Manag 2011;38(1):24-9 PMID: 22097702 SCOPUS ID: 2-s2.0-84856376667 11/22/2011       6 Citations
  • Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. (Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP) Genet Med 2011 Mar;13(3):255-62 PMID: 21173700 SCOPUS ID: 2-s2.0-79251645624 12/22/2010       505 Citations
  • Non-invasive prenatal detection of trisomy 21 using tandem single nucleotide polymorphisms. (Ghanta S, Mitchell ME, Ames M, Hidestrand M, Simpson P, Goetsch M, Thilly WG, Struble CA, Tomita-Mitchell A) PLoS One 2010 Oct 08;5(10):e13184 PMID: 20949031 PMCID: PMC2951898 SCOPUS ID: 2-s2.0-78149464048 10/16/2010       17 Citations
  • Report of the pediatric heart network and national heart, lung, and blood institute working group on the perioperative management of congenital heart disease. (Kaltman JR, Andropoulos DB, Checchia PA, Gaynor JW, Hoffman TM, Laussen PC, Ohye RG, Pearson GD, Pigula F, Tweddell J, Wernovsky G, Del Nido P, Perioperative Working Group) Circulation 2010 Jun 29;121(25):2766-72 PMID: 20585021 06/30/2010       52 Citations
  • Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. (Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME) Physiol Genomics 2010 Sep;42A(1):52-60 PMID: 20551144 PMCID: PMC2957771 SCOPUS ID: 2-s2.0-77957122165 06/17/2010       28 Citations
  • Metakaryotic stem cell lineages in organogenesis of humans and other metazoans. (Gostjeva EV, Koledova V, Tomita-Mitchell A, Mitchell M, Goetsch MA, Varmuza S, Fomina JN, Darroudi F, Thilly WG) Organogenesis 2009 Oct;5(4):191-200 PMID: 20539738 PMCID: PMC2878747 SCOPUS ID: 2-s2.0-74549124470 06/12/2010    
  • Metakaryotic stem cell lineages in organogenesis of humans and other metazoans. (Gostjeva EV, Koledova V, Tomita-Mitchell A, Mitchell M, Goetsch MA, Varmuza S, Fomina JN, Darroudi F, Thilly WG) Organogenesis 2009 Oct;5(4):109-18 PMID: 20357967 PMCID: PMC2808621 04/02/2010    
  • Investigation of somatic NKX2-5 mutations in congenital heart disease. (Draus JM Jr, Hauck MA, Goetsch M, Austin EH 3rd, Tomita-Mitchell A, Mitchell ME) J Med Genet 2009 Feb;46(2):115-22 PMID: 19181906 PMCID: PMC2628540 SCOPUS ID: 2-s2.0-62149117229 02/03/2009       50 Citations
  • GATA4 sequence variants in patients with congenital heart disease. (Tomita-Mitchell A, Maslen CL, Morris CD, Garg V, Goldmuntz E) J Med Genet 2007 Dec;44(12):779-83 PMID: 18055909 PMCID: PMC2652815 SCOPUS ID: 2-s2.0-37249090635 12/07/2007       147 Citations
  • The molecular basis of congenital heart disease. (Mitchell ME, Sander TL, Klinkner DB, Tomita-Mitchell A) Semin Thorac Cardiovasc Surg 2007;19(3):228-37 PMID: 17983950 SCOPUS ID: 2-s2.0-35748971489 11/07/2007       40 Citations
  • Spectrum of heart disease associated with murine and human GATA4 mutation. (Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT) J Mol Cell Cardiol 2007 Dec;43(6):677-85 PMID: 17643447 PMCID: PMC2573470 SCOPUS ID: 2-s2.0-35048838310 07/24/2007       175 Citations
  • Molecular and cellular basis of congenital heart disease. (Sander TL, Klinkner DB, Tomita-Mitchell A, Mitchell ME) Pediatr Clin North Am 2006 Oct;53(5):989-1009, x PMID: 17027620 SCOPUS ID: 2-s2.0-33749431116 10/10/2006       16 Citations
  • Design of an automated multicapillary instrument with fraction collection for DNA mutation discovery by constant denaturant capillary electrophoresis (CDCE). (Li Q, Deka C, Glassner BJ, Arnold K, Li-Sucholeiki XC, Tomita-Mitchell A, Thilly WG, Karger BL) J Sep Sci 2005 Aug;28(12):1375-89 PMID: 16138690 SCOPUS ID: 2-s2.0-23944499103 09/06/2005       11 Citations
  • Scanning the beta-globin gene for mutations in large populations by denaturing capillary and gel electrophoresis. (Li-Sucholeiki XC, Hu G, Perls T, Tomita-Mitchell A, Thilly WG) Electrophoresis 2005 Jun;26(13):2531-8 PMID: 15948210 SCOPUS ID: 2-s2.0-22244480969 06/11/2005       12 Citations
  • Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry. (Li-Sucholeiki XC, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler PM, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, Karger B, Gillespie KM, Ekstrøm PO, Todd JA, Thilly WG) Mutat Res 2005 Mar 01;570(2):267-80 PMID: 15708585 SCOPUS ID: 2-s2.0-13544268461 02/15/2005       15 Citations
  • Diversity and dynamics of a north atlantic coastal Vibrio community. (Thompson JR, Randa MA, Marcelino LA, Tomita-Mitchell A, Lim E, Polz MF) Appl Environ Microbiol 2004 Jul;70(7):4103-10 PMID: 15240289 PMCID: PMC444776 SCOPUS ID: 2-s2.0-3242798356 07/09/2004       204 Citations
  • The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. (Tomita-Mitchell A, Ling LL, Glover CL, Goodluck-Griffith J, Thilly WG) Cancer Res 2003 Sep 15;63(18):5793-8 PMID: 14522901 SCOPUS ID: 2-s2.0-0141731313 10/03/2003       9 Citations
  • Identification of in vivo mutations in exon 5 of the human HPRT gene in a set of pooled T-cell mutants by constant denaturant capillary electrophoresis (CDCE). (Fält S, Kumar R, Wennborg A, Tomita-Mitchell A, Thilly WG, Lambert B) Mutat Res 2000 Jul 20;452(1):57-66 PMID: 10894891 SCOPUS ID: 2-s2.0-0343962276 07/15/2000    
  • Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. (Tomita-Mitchell A, Kat AG, Marcelino LA, Li-Sucholeiki XC, Goodluck-Griffith J, Thilly WG) Mutat Res 2000 May 30;450(1-2):125-38 PMID: 10838138 SCOPUS ID: 2-s2.0-0034733020 06/06/2000       29 Citations
  • Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States. (Herrero-Jimenez P, Tomita-Mitchell A, Furth EE, Morgenthaler S, Thilly WG) Mutat Res 2000 Jan 17;447(1):73-116 PMID: 10686307 SCOPUS ID: 2-s2.0-0033984511 02/25/2000       39 Citations
  • Single nucleotide polymorphism spectra in newborns and centenarians: identification of genes coding for rise of mortal disease. (Tomita-Mitchell A, Muniappan BP, Herrero-Jimenez P, Zarbl H, Thilly WG) Gene 1998 Nov 26;223(1-2):381-91 PMID: 9858772 SCOPUS ID: 2-s2.0-0032570015 12/22/1998       26 Citations
  • Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. (Herrero-Jimenez P, Thilly G, Southam PJ, Tomita-Mitchell A, Morgenthaler S, Furth EE, Thilly WG) Mutat Res 1998 May 25;400(1-2):553-78 PMID: 9685710 SCOPUS ID: 2-s2.0-0032565556 08/01/1998       41 Citations
  • Last update: 04/18/2020
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