Medical College of Wisconsin
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Cara Lynn Mack MD

Cara Lynn Mack MD profile photo picture

Chief, Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Gastroenterology

Member of the Center for Immunology


I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.


Research Areas of Interest

  • Adaptive Immunity
  • Autoimmunity
  • Bile Ducts
  • Biliary Atresia
  • Child
  • Cholangitis, Sclerosing
  • Cholestasis
  • Disease Models, Animal
  • Hepatitis, Autoimmune
  • Immunity, Innate
  • Liver
  • Liver Cirrhosis, Biliary
  • Publications (108)

  • HLA Associations in pediatric autoimmune liver diseases: Current state and future research initiatives. (Mack CL) Front Immunol 2022;13:1019339 PMID: 36311765 PMCID: PMC9609783 SCOPUS ID: 2-s2.0-85140210145 11/01/2022    
  • HLA Associations in pediatric autoimmune liver diseases: Current state and future research initiatives (Mack CL) Frontiers in Immunology 29 September 2022;13 SCOPUS ID: 2-s2.0-85140210145 09/29/2022    
  • The discriminatory ability of FibroScan liver stiffness measurement, controlled attenuation parameter, and FibroScan-aspartate aminotransferase to predict severity of liver disease in children. (Chaidez A, Pan Z, Sundaram SS, Boster J, Lovell M, Sokol RJ, Mack CL) Hepatol Commun 2022 Nov;6(11):3015-3023 PMID: 36069338 PMCID: PMC9592794 SCOPUS ID: 2-s2.0-85137525517 09/08/2022    
  • Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome (Shneider BL, Spino CA, Kamath BM, Magee JC, Ignacio RV, Huang S, Horslen SP, Molleston JP, Miethke AG, Kohli R, Leung DH, Jensen MK, Loomes KM, Karpen SJ, Mack C, Rosenthal P, Squires RH, Baker A, Rajwal S, Kelly D, Sokol RJ, Thompson RJ) Hepatology Communications August 2022;6(8):1922-1933 SCOPUS ID: 2-s2.0-85129743910 08/01/2022       1 Citation
  • Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial. (Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P) Lancet Gastroenterol Hepatol 2022 Sep;7(9):830-842 PMID: 35780807 SCOPUS ID: 2-s2.0-85133724905 07/06/2022       8 Citations
  • Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome. (Shneider BL, Spino CA, Kamath BM, Magee JC, Ignacio RV, Huang S, Horslen SP, Molleston JP, Miethke AG, Kohli R, Leung DH, Jensen MK, Loomes KM, Karpen SJ, Mack C, Rosenthal P, Squires RH, Baker A, Rajwal S, Kelly D, Sokol RJ, Thompson RJ, for ChiLDReN and UK IMAGO/IMAGINE Investigators) Hepatol Commun 2022 Aug;6(8):1922-1933 PMID: 35672955 PMCID: PMC9315125 SCOPUS ID: 2-s2.0-85129743910 06/09/2022       1 Citation
  • Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis. (Harrington C, Krishnan S, Mack CL, Cravedi P, Assis DN, Levitsky J) Hepatology 2022 Dec;76(6):1862-1879 PMID: 35611859 SCOPUS ID: 2-s2.0-85131518596 05/26/2022       1 Citation
  • Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study. (Loomes KM, Squires RH, Kelly D, Rajwal S, Soufi N, Lachaux A, Jankowska I, Mack C, Setchell KDR, Karthikeyan P, Kennedy C, Dorenbaum A, Desai NK, Garner W, Jaecklin T, Vig P, Miethke A, Thompson RJ) Hepatol Commun 2022 Sep;6(9):2379-2390 PMID: 35507739 PMCID: PMC9426380 SCOPUS ID: 2-s2.0-85129902577 05/05/2022       4 Citations
  • The Discriminatory Ability of FibroScan Liver Stiffness Measurement, Controlled Attenuation Parameter and FibroScan-AST to Predict Severity of Liver Disease in Children (Chaidez A, Pan Z, Sundaram SS, Boster J, Lovell M, Sokol RJ, Mack CL) Hepatol Commun Accepted for publication 04/12/2022    
  • Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia. (Bass LM, Ye W, Hawthorne K, Leung DH, Murray KF, Molleston JP, Romero R, Karpen S, Rosenthal P, Loomes KM, Wang KS, Squires RH, Miethke A, Ng VL, Horslen S, Kyle Jensen M, Sokol RJ, Magee JC, Shneider BL, ChiLDReN) Hepatology 2022 Sep;76(3):712-726 PMID: 35271743 PMCID: PMC9378352 SCOPUS ID: 2-s2.0-85134062903 03/11/2022       2 Citations
  • Cholangitis Definition and Treatment after Kasai Hepatoportoenterostomy for Biliary Atresia: A Delphi Process and International Expert Panel. (Calinescu AM, Madadi-Sanjani O, Mack C, Schreiber RA, Superina R, Kelly D, Petersen C, Wildhaber BE) J Clin Med 2022 Jan 19;11(3) PMID: 35159946 PMCID: PMC8836553 SCOPUS ID: 2-s2.0-85125194657 02/16/2022       4 Citations
  • Diagnostic Tools for Early Detection of Biliary Atresia: Is a Newborn Screen Attainable? (Corrado MM, Mack CL) Clin Liver Dis (Hoboken) 2022 Jan;19(1):25-28 PMID: 35106146 PMCID: PMC8785912 SCOPUS ID: 2-s2.0-85123475313 02/03/2022    
  • Primary vs. salvage liver transplantation for biliary atresia: A retrospective cohort study. (Yoeli D, Choudhury RA, Sundaram SS, Mack CL, Roach JP, Karrer FM, Wachs ME, Adams MA) J Pediatr Surg 2022 Oct;57(10):407-413 PMID: 35065808 SCOPUS ID: 2-s2.0-85123071257 01/24/2022       2 Citations
  • Regulatory T Cell (Treg) Cytotoxic T Lymphocyte–associated Antigen-4 Deficits in Biliary Atresia (BA) and Disease Rescue With Treg Augmentation in Murine BA (Yuhuan Luo,1 Joseph Bednarek,2 Alexander Chaidez,1 Shaikh Atif,3 Dong Wang,4 and Cara L. Mack) Gastro Hep Advances 2022;1:461–47 12/12/2021    
  • Pediatric Autoimmune Liver Diseases: Autoimmune Hepatitis and Primary Sclerosing Cholangitis. (Kemme S, Mack CL) Pediatr Clin North Am 2021 Dec;68(6):1293-1307 PMID: 34736590 SCOPUS ID: 2-s2.0-85118509157 11/06/2021       1 Citation
  • Malnutrition in Biliary Atresia: Assessment, Management, and Outcomes. (Boster JM, Feldman AG, Mack CL, Sokol RJ, Sundaram SS) Liver Transpl 2022 Mar;28(3):483-492 PMID: 34669243 PMCID: PMC8857023 SCOPUS ID: 2-s2.0-85118710766 10/21/2021       4 Citations
  • Severe Seronegative Hepatitis-associated Aplastic Anemia: Looking for the Best Treatment. (Kemme S, Feldman AG, Mack C) J Pediatr Gastroenterol Nutr 2021 Aug 01;73(2):e48 PMID: 34016886 PMCID: PMC8373680 SCOPUS ID: 2-s2.0-85114522405 05/22/2021    
  • Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study. (Martinez M, Perito ER, Valentino P, Mack CL, Aumar M, Broderick A, Draijer LG, Fagundes EDT, Furuya KN, Gupta N, Horslen S, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Miloh T, Mogul D, Mohammed S, Ovchinsky N, Rao G, Ricciuto A, Rodrigues Ferreira A, Schwarz KB, Smolka V, Tanaka A, Tessier MEM, Venkat VL, Vitola BE, Woynarowski M, Zerofsky M, Deneau MR) Hepatology 2021 Oct;74(4):2047-2057 PMID: 34008252 PMCID: PMC8530456 SCOPUS ID: 2-s2.0-85114458548 05/20/2021       3 Citations
  • Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study. (Kamath BM, Ye W, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Murray KF, Rosenthal P, Squires JE, Teckman J, Wang KS, Thompson R, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN)) Hepatol Commun 2020 Mar;4(3):387-398 PMID: 33313463 PMCID: PMC7049675 SCOPUS ID: 2-s2.0-85087112043 12/15/2020       29 Citations
  • Modeling Outcomes in Children With Biliary Atresia With Native Liver After 2 Years of Age. (Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS, Soufi N, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL, Rosenthal P, Shneider BL, Squires RH, Sokol RJ, Karpen SJ, Childhood Liver Disease Research Network) Hepatol Commun 2020 Dec;4(12):1824-1834 PMID: 33305153 PMCID: PMC7706301 SCOPUS ID: 2-s2.0-85113963061 12/12/2020       6 Citations
  • Oral Vancomycin, Ursodeoxycholic Acid, or No Therapy for Pediatric Primary Sclerosing Cholangitis: A Matched Analysis. (Deneau MR, Mack C, Mogul D, Perito ER, Valentino PL, Amir AZ, DiGuglielmo M, Draijer LG, El-Matary W, Furuya KN, Gupta N, Hochberg JT, Horslen S, Jensen MK, Jonas MM, Kerkar N, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mohammad S, Ovchinsky N, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Vitola B, Zizzo A, Guthery SL) Hepatology 2021 Mar;73(3):1061-1073 PMID: 32946600 PMCID: PMC8557636 SCOPUS ID: 2-s2.0-85096470448 09/19/2020       25 Citations
  • Outcomes of Severe Seronegative Hepatitis-associated Aplastic Anemia: A Pediatric Case Series. (Kemme S, Stahl M, Brigham D, Lovell MA, Nakano T, Feldman AG, Mack C) J Pediatr Gastroenterol Nutr 2021 Feb 01;72(2):194-201 PMID: 32925550 PMCID: PMC7856235 SCOPUS ID: 2-s2.0-85099721796 09/15/2020       4 Citations
  • Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia. (Azeltine MW, Chavez EJ, Nemec KM, Bednarek JM, Asokan R, Balasubramaniyan N, Zgheib C, Mack CL, Roach JP) J Surg Res 2020 Dec;256:663-672 PMID: 32818799 SCOPUS ID: 2-s2.0-85089403967 08/21/2020       4 Citations
  • Unique Cholangiocyte-Targeted IgM Autoantibodies Correlate With Poor Outcome in Biliary Atresia. (Luo Y, Brigham D, Bednarek J, Torres R, Wang D, Ahmad S, Mack CL) Hepatology 2021 May;73(5):1855-1867 PMID: 32767570 PMCID: PMC7867668 SCOPUS ID: 2-s2.0-85097322099 08/09/2020       7 Citations
  • Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension. (Teckman J, Rosenthal P, Hawthorne K, Spino C, Bass LM, Murray KF, Kerkar N, Magee JC, Karpen S, Heubi JE, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Sherker AH, Sokol RJ, ChiLDReN (Childhood Liver Disease Research Network)) J Pediatr 2020 Dec;227:81-86.e4 PMID: 32663593 PMCID: PMC7686087 SCOPUS ID: 2-s2.0-85090308507 07/15/2020       5 Citations
  • Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders. (Karpen SJ, Kelly D, Mack C, Stein P) Hepatol Int 2020 Sep;14(5):677-689 PMID: 32653991 SCOPUS ID: 2-s2.0-85087807065 07/13/2020       33 Citations
  • Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome. (Kamath BM, Spino C, McLain R, Magee JC, Fredericks EM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Alonso EM, Murray KF, Loomes KM, Kyle Jensen M, Karpen SJ, Rosenthal P, Thomas D, Sokol RJ, Shneider BL, Childhood Liver Disease Research Network (ChiLDReN)) Hepatol Commun 2020 Jul;4(7):1012-1018 PMID: 32626833 PMCID: PMC7327199 SCOPUS ID: 2-s2.0-85113928487 07/07/2020       3 Citations
  • Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting American Association for the Study of Liver Diseases Guidelines. (Vierling JM, Kerkar N, Czaja AJ, Mack CL, Adams D, Assis DN, Manns MP, Mayo MJ, Nayfeh T, Majzoub AMM, Alzuabi MA, Ding J, Haffar S, Murad MH, Alsawas M) Hepatology 2020 Aug;72(2):753-769 PMID: 32500593 SCOPUS ID: 2-s2.0-85089775331 06/06/2020       18 Citations
  • Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type 1. (Feldman AG, Parsons JA, Dutmer CM, Veerapandiyan A, Hafberg E, Maloney N, Mack CL) J Pediatr 2020 Oct;225:252-258.e1 PMID: 32473148 SCOPUS ID: 2-s2.0-85089133897 05/31/2020       39 Citations
  • The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children. (Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, Tavares Fagundes ED, El-Matary W, Ferrari F, Furuya KN, Gupta N, Hochberg JT, Homan M, Horslen S, Iorio R, Jensen MK, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammad S, Mohan P, Moroz S, Ovchinsky N, Palle S, Papadopoulou A, Rao G, Rodrigues Ferreira A, Sathya P, Schwarz KB, Shah U, Shteyer E, Singh R, Smolka V, Soufi N, Tanaka A, Varier R, Vitola B, Woynarowski M, Zerofsky M, Zizzo A, Guthery SL) Hepatology 2021 Mar;73(3):1074-1087 PMID: 32464706 PMCID: PMC8557635 SCOPUS ID: 2-s2.0-85097772175 05/29/2020       12 Citations
  • Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis. (El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BGP, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR) Clin Gastroenterol Hepatol 2021 May;19(5):1067-1070.e2 PMID: 32360820 PMCID: PMC8788582 SCOPUS ID: 2-s2.0-85088554008 05/04/2020       2 Citations
  • Inherited Cholestatic Diseases in the Era of Personalized Medicine. (Goldberg A, Mack CL) Clin Liver Dis (Hoboken) 2020 Mar;15(3):105-109 PMID: 32257121 PMCID: PMC7128029 SCOPUS ID: 2-s2.0-85082944695 04/08/2020       4 Citations
  • The Importance of Prioritizing Pre and Posttransplant Immunizations in an Era of Vaccine Refusal and Epidemic Outbreaks. (Feldman AG, Hsu EK, Mack CL) Transplantation 2020 Jan;104(1):33-38 PMID: 31876696 PMCID: PMC6936334 SCOPUS ID: 2-s2.0-85077199520 12/27/2019       6 Citations
  • Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. (Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ) Hepatology 2020 Aug;72(2):671-722 PMID: 31863477 SCOPUS ID: 2-s2.0-85084202582 12/22/2019       253 Citations
  • A Prospective Trial of Withdrawal and Reinstitution of Ursodeoxycholic Acid in Pediatric Primary Sclerosing Cholangitis. (Black DD, Mack C, Kerkar N, Miloh T, Sundaram SS, Anand R, Gupta A, Alonso E, Arnon R, Bulut P, Karpen S, Lin CH, Rosenthal P, Ryan M, Squires RH, Valentino P, Elsea SH, Shneider BL) Hepatol Commun 2019 Nov;3(11):1482-1495 PMID: 31701072 PMCID: PMC6824074 SCOPUS ID: 2-s2.0-85085092262 11/09/2019       8 Citations
  • Assessing the Validity of Adult-derived Prognostic Models for Primary Sclerosing Cholangitis Outcomes in Children. (Deneau MR, Valentino PL, Mack C, Alqoaer K, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, El-Matary W, Ferrari F, Furuya KN, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Kim KM, Kolho KL, Koot B, Iorio R, Martinez M, Miloh T, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Woynarowski M, Guthery S) J Pediatr Gastroenterol Nutr 2020 Jan;70(1):e12-e17 PMID: 31651664 SCOPUS ID: 2-s2.0-85077298792 10/28/2019       2 Citations
  • Synovial Cell Sarcoma in an Adolescent Liver Transplant Recipient. (Jaramillo C, Gilani A, Haag M, Donaldson N, Mack C) ACG Case Rep J 2019 May;6(5):e00091 PMID: 31616756 PMCID: PMC6658059 10/17/2019    
  • The Contribution of B Cells in Autoimmune Liver Diseases. (Taylor SA, Assis DN, Mack CL) Semin Liver Dis 2019 Nov;39(4):422-431 PMID: 31226726 PMCID: PMC6800599 SCOPUS ID: 2-s2.0-85072520710 06/22/2019       22 Citations
  • Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy. (Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL, Childhood Liver Disease Research Network) Hepatol Commun 2019 May;3(5):685-696 PMID: 31061956 PMCID: PMC6492477 SCOPUS ID: 2-s2.0-85087816796 05/08/2019       9 Citations
  • Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: Predictors of Gamma Glutamyltransferase Normalization and Favorable Clinical Course. (Deneau M, Perito E, Ricciuto A, Gupta N, Kamath BM, Palle S, Vitola B, Smolka V, Ferrari F, Amir AZ, Miloh T, Papadopoulou A, Mohan P, Mack C, Kolho KL, Iorio R, El-Matary W, Venkat V, Chan A, Saubermann L, Valentino PL, Shah U, Miethke A, Lin H, Jensen MK) J Pediatr 2019 Jun;209:92-96.e1 PMID: 30878206 PMCID: PMC6535363 SCOPUS ID: 2-s2.0-85062695603 03/18/2019       9 Citations
  • A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia. (Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ, The ChiLDReN Network) J Pediatr Gastroenterol Nutr 2019 Apr;68(4):495-501 PMID: 30664564 PMCID: PMC6428610 SCOPUS ID: 2-s2.0-85063638849 01/22/2019       19 Citations
  • Gamma Glutamyltransferase Reduction Is Associated With Favorable Outcomes in Pediatric Primary Sclerosing Cholangitis. (Deneau MR, Mack C, Abdou R, Amin M, Amir A, Auth M, Bazerbachi F, Marie Broderick A, Chan A, DiGuglielmo M, El-Matary W, El-Youssef M, Ferrari F, Furuya KN, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Mo Kim K, Kolho KL, Konidari A, Koot B, Iorio R, Martinez M, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Valentino PL, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Miloh T) Hepatol Commun 2018 Nov;2(11):1369-1378 PMID: 30411083 PMCID: PMC6211333 SCOPUS ID: 2-s2.0-85062720274 11/10/2018       20 Citations
  • Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. (Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network) Hepatol Commun 2018 Oct;2(10):1184-1198 PMID: 30288474 PMCID: PMC6167076 SCOPUS ID: 2-s2.0-85067213259 10/06/2018       41 Citations
  • Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. (Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC, ChiLDReN Network) J Pediatr 2018 Nov;202:179-185.e4 PMID: 30244988 PMCID: PMC6365098 SCOPUS ID: 2-s2.0-85053735283 09/25/2018       18 Citations
  • From Hepatocyte to Cholangiocyte: The Remarkable Potential of Transdifferentiation to Treat Cholestatic Diseases. (Kamath B, Mack C) Hepatology 2019 Apr;69(4):1828-1830 PMID: 30179266 SCOPUS ID: 2-s2.0-85061813661 09/05/2018       3 Citations
  • Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia. (Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL) Hepatology 2018 Nov;68(5):1890-1904 PMID: 29679373 PMCID: PMC6195851 SCOPUS ID: 2-s2.0-85050869511 04/22/2018       18 Citations
  • Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century. (Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ) Hepatology 2018 Sep;68(3):1163-1173 PMID: 29604222 PMCID: PMC6167205 SCOPUS ID: 2-s2.0-85053079387 04/01/2018       143 Citations
  • Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. (Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN)) J Pediatr 2018 May;196:139-147.e3 PMID: 29519540 PMCID: PMC5924604 SCOPUS ID: 2-s2.0-85043331672 03/10/2018       23 Citations
  • Introducing Ronald J. Sokol, M.D.-our 2018 AASLD president. (Mack CL) Hepatology 2018 May;67(5):1669-1672 PMID: 29466842 SCOPUS ID: 2-s2.0-85044482073 02/22/2018    
  • Lack of Correlation of Liver Tests With Fibrosis Stage at Diagnosis in Pediatric Primary Sclerosing Cholangitis. (Cotter JM, Browne LP, Capocelli KE, McCoy A, Mack CL) J Pediatr Gastroenterol Nutr 2018 Feb;66(2):227-233 PMID: 29356767 SCOPUS ID: 2-s2.0-85041590902 01/23/2018       2 Citations
  • Primary sclerosing cholangitis: Unique aspects of disease in children. (Cotter JM, Mack CL) Clin Liver Dis (Hoboken) 2017 Nov;10(5):120-123 PMID: 30992770 PMCID: PMC6467120 SCOPUS ID: 2-s2.0-85036521452 11/30/2017       2 Citations
  • Update on investigations pertaining to the pathogenesis of biliary atresia. (Kilgore A, Mack CL) Pediatr Surg Int 2017 Dec;33(12):1233-1241 PMID: 29063959 PMCID: PMC5894874 SCOPUS ID: 2-s2.0-85032016321 10/25/2017       28 Citations
  • Use of Fully Covered Self-expanding Metal Biliary Stents in Pediatrics: A Case Series. (Mark JA, Mack CL, Marwan AI, Kramer RE) J Pediatr Gastroenterol Nutr 2018 Mar;66(3):e71-e75 PMID: 28837510 SCOPUS ID: 2-s2.0-85042396763 08/25/2017    
  • The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. (Deneau MR, El-Matary W, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya KN, Gottrand M, Gottrand F, Gupta N, Homan M, Kamath BM, Kim KM, Kolho KL, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M, Miloh T, Mohan P, O'Cathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Jensen MK) Hepatology 2017 Aug;66(2):518-527 PMID: 28390159 SCOPUS ID: 2-s2.0-85021369385 04/09/2017       97 Citations
  • Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. (Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL) J Pediatr Gastroenterol Nutr 2017 Jul;65(1):80-85 PMID: 28272159 PMCID: PMC5482766 SCOPUS ID: 2-s2.0-85014716269 03/09/2017       24 Citations
  • Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. (Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL, Childhood Liver Disease Research Network (ChiLDReN)) Hepatology 2017 May;65(5):1645-1654 PMID: 28027587 PMCID: PMC5397365 SCOPUS ID: 2-s2.0-85017347943 12/28/2016       40 Citations
  • Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. (Sundaram SS, Mack CL, Feldman AG, Sokol RJ) Liver Transpl 2017 Jan;23(1):96-109 PMID: 27650268 PMCID: PMC5177506 SCOPUS ID: 2-s2.0-85006494243 09/22/2016       118 Citations
  • Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. (Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ) J Pediatr Gastroenterol Nutr 2017 Jan;64(1):154-168 PMID: 27429428 SCOPUS ID: 2-s2.0-84978757526 07/19/2016       226 Citations
  • CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. (Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR) J Pediatr 2016 Mar;170:142-8.e1 PMID: 26743497 PMCID: PMC4833455 SCOPUS ID: 2-s2.0-84960075342 01/09/2016       7 Citations
  • Pediatric primary sclerosing cholangitis (Molla-Hosseini D, Mack CL) Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments 1 January 2016:73-81 SCOPUS ID: 2-s2.0-85018924298 01/01/2016       1 Citation
  • What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis. (Mack CL) Cell Mol Gastroenterol Hepatol 2015 May 01;1(3):267-274 PMID: 26090510 PMCID: PMC4467898 SCOPUS ID: 2-s2.0-84929232775 06/20/2015       30 Citations
  • Biliary Atresia: Clinical Lessons Learned. (Feldman AG, Mack CL) J Pediatr Gastroenterol Nutr 2015 Aug;61(2):167-75 PMID: 25658057 SCOPUS ID: 2-s2.0-84942832146 02/07/2015       66 Citations
  • High-dose IgG therapy mitigates bile duct-targeted inflammation and obstruction in a mouse model of biliary atresia. (Fenner EK, Boguniewicz J, Tucker RM, Sokol RJ, Mack CL) Pediatr Res 2014 Jul;76(1):72-80 PMID: 24727948 PMCID: PMC4062601 SCOPUS ID: 2-s2.0-84902688139 04/15/2014       13 Citations
  • Executive summary: Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: Recommendations from the national institutes of health, the centers for disease control and prevention, the HIV medicine association of the infectious diseases society of America, the pediatric infectious diseases society, and the American academy of pediatrics (Siberry GK, Abzug MJ, Nachman S, Steinbach WJ, Kleiman MB, Gaur A, Flynn P, Shimamura M, Narkewicz M, Mack CL, Levin MJ, Rutstein R, Moscicki AB, Kroger A, Edwards KM, Hobbs CV, McAuley J, Marais B, Clarke D, Gigliotti F, Harrison G, Koumans EH, Kimberlin D, Bhattacharya D, Seward J, Esbenshade JC, Wilson GJ, Maron G, Menzies HJ) Journal of the Pediatric Infectious Diseases Society 1 December 2013;2(4):293-308 SCOPUS ID: 2-s2.0-84949118734 12/01/2013       10 Citations
  • B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. (Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL) PLoS One 2013;8(8):e73644 PMID: 23991203 PMCID: PMC3749125 SCOPUS ID: 2-s2.0-84882586277 08/31/2013       31 Citations
  • Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. (Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC, Childhood Liver Disease Research and Education Network) Hepatology 2013 Nov;58(5):1724-31 PMID: 23703680 PMCID: PMC3844083 SCOPUS ID: 2-s2.0-84887021811 05/25/2013       91 Citations
  • Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. (Tucker RM, Feldman AG, Fenner EK, Mack CL) J Hepatol 2013 Oct;59(4):790-6 PMID: 23685050 PMCID: PMC3855478 SCOPUS ID: 2-s2.0-84884418640 05/21/2013       45 Citations
  • Lack of HLA predominance and HLA shared epitopes in biliary Atresia. (Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM) Springerplus 2013 Dec;2(1):42 PMID: 23505615 PMCID: PMC3595468 SCOPUS ID: 2-s2.0-84876535587 03/19/2013       9 Citations
  • Clues to the etiology of bile duct injury in biliary atresia. (Mack CL, Feldman AG, Sokol RJ) Semin Liver Dis 2012 Nov;32(4):307-16 PMID: 23397531 PMCID: PMC3827890 SCOPUS ID: 2-s2.0-84873364829 02/12/2013       59 Citations
  • Biliary atresia: cellular dynamics and immune dysregulation. (Feldman AG, Mack CL) Semin Pediatr Surg 2012 Aug;21(3):192-200 PMID: 22800972 PMCID: PMC3399127 SCOPUS ID: 2-s2.0-84863842159 07/18/2012       56 Citations
  • Conjugated hyperbilirubinemia in children. (Brumbaugh D, Mack C) Pediatr Rev 2012 Jul;33(7):291-302 PMID: 22753787 SCOPUS ID: 2-s2.0-84863546718 07/04/2012       26 Citations
  • NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. (Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition) J Pediatr Gastroenterol Nutr 2012 Jun;54(6):838-55 PMID: 22487950 SCOPUS ID: 2-s2.0-84861334032 04/11/2012       147 Citations
  • Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease. (Tucker RM, Mack CL) Hepatol Res 2012 May;42(5):502-7 PMID: 22236071 PMCID: PMC3798039 01/13/2012    
  • Infectious hepatitis (Lu B, Mack CL) Berman's Pediatric Decision Making 2011:588-591 SCOPUS ID: 2-s2.0-84882564130 12/01/2011    
  • Neonatal hyperbilirubinemia (Chambers B, Mack CL) Berman's Pediatric Decision Making 2011:287-291 SCOPUS ID: 2-s2.0-84882459693 12/01/2011    
  • Elevated liver tests after 6 months of age (Lu B, Mack CL) Berman's Pediatric Decision Making 2011:234-237 SCOPUS ID: 2-s2.0-84882457550 12/01/2011    
  • Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. (Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL) Hepatology 2012 Apr;55(4):1130-8 PMID: 22105891 PMCID: PMC3319336 SCOPUS ID: 2-s2.0-84859137659 11/23/2011       75 Citations
  • Elevated Liver Tests After 6 Months of Age (Lu B, Mack CL) Berman's Pediatric Decision Making: Expert Consult 30 June 2011:234-237 SCOPUS ID: 2-s2.0-85135733996 06/30/2011    
  • Infectious Hepatitis (Lu B, Mack CL) Berman's Pediatric Decision Making: Expert Consult 30 June 2011:588-591 SCOPUS ID: 2-s2.0-85135731546 06/30/2011    
  • Autoimmune hepatitis (Kerkar N, Mack CL) Liver Disease in Children, Fourth Edition 1 January 2011:311-321 SCOPUS ID: 2-s2.0-84931301152 01/01/2011       3 Citations
  • α-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia. (Lu BR, Brindley SM, Tucker RM, Lambert CL, Mack CL) Gastroenterology 2010 Nov;139(5):1753-61 PMID: 20659472 PMCID: PMC3792016 SCOPUS ID: 2-s2.0-78049474694 07/28/2010       65 Citations
  • Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. (Rand EB, Karpen SJ, Kelly S, Mack CL, Malatack JJ, Sokol RJ, Whitington PF) J Pediatr 2009 Oct;155(4):566-71 PMID: 19560784 SCOPUS ID: 2-s2.0-70249151112 06/30/2009       113 Citations
  • Inflammation and biliary tract injury. (Lu BR, Mack CL) Curr Opin Gastroenterol 2009 May;25(3):260-4 PMID: 19396964 SCOPUS ID: 2-s2.0-67651123302 04/28/2009       16 Citations
  • Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia. (Barnes BH, Tucker RM, Wehrmann F, Mack DG, Ueno Y, Mack CL) Liver Int 2009 Sep;29(8):1253-61 PMID: 19040538 PMCID: PMC3783657 SCOPUS ID: 2-s2.0-70350041702 12/02/2008       50 Citations
  • End-stage liver disease and liver transplant: current situation and key issues. (Sokal EM, Goldstein D, Ciocca M, Lewindon P, Ni YH, Silveira T, Sibal A, Dhawan A, Mack C, Bucuvalas J, End-Stage Liver Disease Working Group) J Pediatr Gastroenterol Nutr 2008 Aug;47(2):239-46 PMID: 18664882 SCOPUS ID: 2-s2.0-56049117209 07/31/2008       16 Citations
  • The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. (Mack CL) Semin Liver Dis 2007 Aug;27(3):233-42 PMID: 17682970 PMCID: PMC3796656 SCOPUS ID: 2-s2.0-34548131082 08/09/2007       142 Citations
  • Impact of graft type on outcome in pediatric liver transplantation: a report From Studies of Pediatric Liver Transplantation (SPLIT). (Diamond IR, Fecteau A, Millis JM, Losanoff JE, Ng V, Anand R, Song C, SPLIT Research Group) Ann Surg 2007 Aug;246(2):301-10 PMID: 17667510 PMCID: PMC1933573 SCOPUS ID: 2-s2.0-34547565747 08/02/2007       185 Citations
  • Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. (Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP) Gastroenterology 2007 Jul;133(1):278-87 PMID: 17631149 PMCID: PMC1949019 SCOPUS ID: 2-s2.0-34447100540 07/17/2007       82 Citations
  • Serum cytokines as biomarkers of disease and clues to pathogenesis. (Mack CL) Hepatology 2007 Jul;46(1):6-8 PMID: 17596866 SCOPUS ID: 2-s2.0-34547422929 06/29/2007       19 Citations
  • Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. (Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, Mack CL) Viral Immunol 2007;20(1):34-43 PMID: 17425419 PMCID: PMC1978183 SCOPUS ID: 2-s2.0-34247276113 04/12/2007       28 Citations
  • Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. (Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, Gill RG) Hepatology 2006 Nov;44(5):1231-9 PMID: 17058262 PMCID: PMC1948978 SCOPUS ID: 2-s2.0-33750999089 10/24/2006       103 Citations
  • Acute hepatitis and liver failure associated with influenza A infection in children. (Whitworth JR, Mack CL, O'Connor JA, Narkewicz MR, Mengshol S, Sokol RJ) J Pediatr Gastroenterol Nutr 2006 Oct;43(4):536-8 PMID: 17033532 SCOPUS ID: 2-s2.0-33750025716 10/13/2006       20 Citations
  • Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability. (Mack CL, Zelko FA, Lokar J, Superina R, Alonso EM, Blei AT, Whitington PF) Pediatrics 2006 Mar;117(3):e405-12 PMID: 16481447 SCOPUS ID: 2-s2.0-33645038616 02/17/2006       85 Citations
  • Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia. (Mack CL, Tucker RM, Sokol RJ, Kotzin BL) Clin Immunol 2005 May;115(2):200-9 PMID: 15885644 PMCID: PMC1950158 SCOPUS ID: 2-s2.0-18844416103 05/12/2005       87 Citations
  • Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. (Whitington PF, Malladi P, Melin-Aldana H, Azzam R, Mack CL, Sahai A) Pediatr Res 2005 Jun;57(6):837-44 PMID: 15845635 SCOPUS ID: 2-s2.0-19444366101 04/23/2005       54 Citations
  • Unraveling the pathogenesis and etiology of biliary atresia. (Mack CL, Sokol RJ) Pediatr Res 2005 May;57(5 Pt 2):87R-94R PMID: 15817506 SCOPUS ID: 2-s2.0-17844391845 04/09/2005       117 Citations
  • Optimizing outcomes and bridging biliary atresia into adulthood. (Sokol RJ, Mack CL) Hepatology 2005 Feb;41(2):231-3 PMID: 15657917 SCOPUS ID: 2-s2.0-12844280475 01/20/2005       13 Citations
  • Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. (Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD) Pediatr Res 2004 Jul;56(1):79-87 PMID: 15128911 PMCID: PMC1948976 SCOPUS ID: 2-s2.0-3042689562 05/07/2004       165 Citations
  • Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. (Zhang DY, Sabla G, Shivakumar P, Tiao G, Sokol RJ, Mack C, Shneider BL, Aronow B, Bezerra JA) Hepatology 2004 Apr;39(4):954-62 PMID: 15057899 SCOPUS ID: 2-s2.0-1842480207 04/02/2004       68 Citations
  • Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis. (Mack CL, Vanderlugt-Castaneda CL, Neville KL, Miller SD) J Neuroimmunol 2003 Nov;144(1-2):68-79 PMID: 14597100 SCOPUS ID: 2-s2.0-0142258022 11/05/2003       101 Citations
  • Pathogenesis and outcome of biliary atresia: current concepts. (Sokol RJ, Mack C, Narkewicz MR, Karrer FM) J Pediatr Gastroenterol Nutr 2003 Jul;37(1):4-21 PMID: 12827000 SCOPUS ID: 2-s2.0-0642315150 06/27/2003       244 Citations
  • Does JAGGED 1 have a role in the pathogenesis of biliary atresia? The significance of JAGGED 1 mutations detected in severe cases of extrahepatic biliary atresia: Commentary (Mack CL) Journal of Pediatric Gastroenterology and Nutrition May 2003;36(5):654-655 SCOPUS ID: 2-s2.0-4644264957 05/01/2003    
  • Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis. (Mack CL, Superina RA, Whitington PF) J Pediatr 2003 Feb;142(2):197-9 PMID: 12584545 SCOPUS ID: 2-s2.0-0037324149 02/14/2003       92 Citations
  • The surgical management of biliary atresia: Does variceal hemorrhage contribute to decision making? (Whitington PF, Mack CL, Superina RA) Hepatology 2002;36(2):498-499 SCOPUS ID: 2-s2.0-0036321452 01/01/2002    
  • Etiopathogenesis of biliary atresia. (Sokol RJ, Mack C) Semin Liver Dis 2001 Nov;21(4):517-24 PMID: 11745039 SCOPUS ID: 2-s2.0-0035204301 12/18/2001       129 Citations
  • Living donor liver transplantation for children with liver failure and concurrent multiple organ system failure. (Mack CL, Ferrario M, Abecassis M, Whitington PF, Superina RA, Alonso EM) Liver Transpl 2001 Oct;7(10):890-5 PMID: 11679988 SCOPUS ID: 2-s2.0-0034756717 10/27/2001       35 Citations
  • Early speech delay and hepatitis as presenting signs of homocystinuria. (Mack CL, Emerick KM, Kovarik P, Charrow J) J Pediatr Gastroenterol Nutr 2001 Aug;33(2):221-3 PMID: 11568530 SCOPUS ID: 2-s2.0-0034861110 09/25/2001       4 Citations
  • Pulmonary complications following liver transplantation in pediatric patients. (Mack CL, Millis JM, Whitington PF, Alonso EM) Pediatr Transplant 2000 Feb;4(1):39-44 PMID: 10731057 SCOPUS ID: 2-s2.0-0033959370 03/24/2000       40 Citations
  • Last update: 11/11/2022