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Medical College of Wisconsin

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David Harder PhD, MS

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Research Center
Member of the Neuroscience Research Center

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Publications (207)

Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells. (Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR) PLoS One 2017;12(5):e0176796 PMID: 28472069 PMCID: PMC5417564 SCOPUS ID: 2-s2.0-85019077900 05/05/2017 8 Citations

Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen-Glucose Deprivation in Cortical Neurons. (Zhang H, Falck JR, Roman RJ, Harder DR, Koehler RC, Yang ZJ) Cell Mol Neurobiol 2017 Oct;37(7):1279-1286 PMID: 28110484 PMCID: PMC5522363 SCOPUS ID: 2-s2.0-85009885053 01/23/2017 13 Citations

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. (Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A) J Neurochem 2017 Mar;140(5):814-825 PMID: 28002622 PMCID: PMC5310989 SCOPUS ID: 2-s2.0-85013779052 12/22/2016 25 Citations

Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. (Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR) Prostaglandins Other Lipid Mediat 2016 Jul;124:16-26 PMID: 27174801 PMCID: PMC5287377 SCOPUS ID: 2-s2.0-84973896991 05/14/2016 21 Citations

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen –glucose deprivation (Zhang Y, Hong G, Lee KS, Hammock B, Gebremedhin D, Koehler R, Harder DR, Sapirstein A) Journal of Neurochemistry 01/04/2016

Expression of CYP 4A ω- hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes (Gebremedhin D, David Zhang X, Carver K, Rau N, Roman, R, Harder DR) Elsevier 01/04/2016

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. (Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD) PLoS One 2015;10(12):e0145335 PMID: 26683993 PMCID: PMC4686180 SCOPUS ID: 2-s2.0-84956951131 12/20/2015 1 Citation

Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2015;10(8):e0137369 PMID: 26322640 PMCID: PMC4554722 SCOPUS ID: 2-s2.0-84943279669 09/01/2015 4 Citations

Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia. (Liu X, Gebremedhin D, Harder DR, Koehler RC) J Appl Physiol (1985) 2015 Nov 15;119(10):1202-9 PMID: 25792716 PMCID: PMC4747900 SCOPUS ID: 2-s2.0-84947289919 03/21/2015 16 Citations

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. (Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ) PLoS One 2014;9(11):e112878 PMID: 25397684 PMCID: PMC4232417 SCOPUS ID: 2-s2.0-84911866190 11/15/2014 33 Citations

Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature. (Carver KA, Lourim D, Tryba AK, Harder DR) Am J Physiol Cell Physiol 2014 Dec 01;307(11):C989-98 PMID: 25055826 PMCID: PMC4254955 SCOPUS ID: 2-s2.0-84914140128 07/25/2014 54 Citations

Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats. (Pabbidi MR, Mazur O, Fan F, Farley JM, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2014 Apr 01;306(7):H989-H1000 PMID: 24464756 PMCID: PMC3962634 SCOPUS ID: 2-s2.0-84900531560 01/28/2014 25 Citations

Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID: 24324647 PMCID: PMC3851470 SCOPUS ID: 2-s2.0-84891893696 12/11/2013 88 Citations

Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes. (Sarkar P, Zaja I, Bienengraeber M, Rarick KR, Terashvili M, Canfield S, Falck JR, Harder DR) Am J Physiol Heart Circ Physiol 2014 Feb 15;306(4):H475-84 PMID: 24285116 PMCID: PMC3920242 SCOPUS ID: 2-s2.0-84894068191 11/29/2013 64 Citations

Endogenous events modulating myogenic regulation of cerebrovascular function. (Gebremedhin D, Gopalakrishnan S, Harder DR) Curr Vasc Pharmacol 2014;12(6):810-7 PMID: 24066934 SCOPUS ID: 2-s2.0-84926287512 09/27/2013 18 Citations

Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries. (Gebremedhin D, Terashvili M, Wickramasekera N, Zhang DX, Rau N, Miura H, Harder DR) PLoS One 2013;8(7):e68498 PMID: 23861911 PMCID: PMC3702596 SCOPUS ID: 2-s2.0-84879802004 07/19/2013 21 Citations

Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. (Wickramasekera NT, Gebremedhin D, Carver KA, Vakeel P, Ramchandran R, Schuett A, Harder DR) J Appl Physiol (1985) 2013 Jan 15;114(2):252-61 PMID: 23172031 PMCID: PMC3544499 SCOPUS ID: 2-s2.0-84872285379 11/23/2012 9 Citations

Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats. (Pabbidi MR, Juncos J, Juncos L, Renic M, Tullos HJ, Lazar J, Jacob HJ, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H311-7 PMID: 23144316 PMCID: PMC3543673 SCOPUS ID: 2-s2.0-84872388133 11/13/2012 19 Citations

The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. (Terashvili M, Sarkar P, Nostrand MV, Falck JR, Harder DR) Neuroscience 2012 Oct 25;223:68-76 PMID: 22863680 PMCID: PMC4003556 SCOPUS ID: 2-s2.0-84865450193 08/07/2012 42 Citations

Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. (Yang ZJ, Carter EL, Kibler KK, Kwansa H, Crafa DA, Martin LJ, Roman RJ, Harder DR, Koehler RC) J Neurochem 2012 Apr;121(1):168-79 PMID: 22251169 PMCID: PMC3303996 SCOPUS ID: 2-s2.0-84862831734 01/19/2012 38 Citations

Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. (Renic M, Kumar SN, Gebremedhin D, Florence MA, Gerges NZ, Falck JR, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2012 Mar 15;302(6):H1285-93 PMID: 22245774 PMCID: PMC3311475 SCOPUS ID: 2-s2.0-84863229646 01/17/2012 32 Citations

Reactive oxygen species modulate astrocyte and capillary cell functions in the regulation of cerebral blood flow. In: Hand Book of Systems Biology of Oxidative Stress (Gebremedhin D, Wickramasekera NT, and Harder DR) Hand Book of Systems Biology of Oxidative Stress 01/02/2012

Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation. (Liu X, Li C, Falck JR, Harder DR, Koehler RC) Am J Physiol Heart Circ Physiol 2012 Mar 01;302(5):H1075-85 PMID: 22198176 PMCID: PMC3311453 SCOPUS ID: 2-s2.0-84863177918 12/27/2011 31 Citations

Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. (Sarkar P, Narayanan J, Harder DR) Neuroscience 2011 Oct 27;194:241-9 PMID: 21843605 PMCID: PMC3183272 SCOPUS ID: 2-s2.0-80053098381 08/17/2011 37 Citations

Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. (Liu X, Li C, Gebremedhin D, Hwang SH, Hammock BD, Falck JR, Roman RJ, Harder DR, Koehler RC) Am J Physiol Heart Circ Physiol 2011 Aug;301(2):H373-81 PMID: 21602473 PMCID: PMC3154671 SCOPUS ID: 2-s2.0-79961046351 05/24/2011 37 Citations

Cytochrome P450 eicosanoids and cerebral vascular function. (Imig JD, Simpkins AN, Renic M, Harder DR) Expert Rev Mol Med 2011 Mar 01;13:e7 PMID: 21356152 PMCID: PMC3613250 SCOPUS ID: 2-s2.0-79956129813 03/02/2011 70 Citations

Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow. (Harder DR, Narayanan J, Gebremedhin D) Am J Physiol Heart Circ Physiol 2011 May;300(5):H1557-65 PMID: 21257913 PMCID: PMC3283039 SCOPUS ID: 2-s2.0-79955787397 01/25/2011 50 Citations

Adenosine can mediate its actions through generation of reactive oxygen species. (Gebremedhin D, Weinberger B, Lourim D, Harder DR) J Cereb Blood Flow Metab 2010 Oct;30(10):1777-90 PMID: 20531463 PMCID: PMC3023402 SCOPUS ID: 2-s2.0-77957709548 06/10/2010 26 Citations

Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 omega-hydroxylase activity. (Ohata H, Gebremedhin D, Narayanan J, Harder DR, Koehler RC) J Appl Physiol (1985) 2010 Aug;109(2):412-7 PMID: 20489034 PMCID: PMC2928585 SCOPUS ID: 2-s2.0-77955616253 05/22/2010 12 Citations

Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. (Cao S, Wang LC, Kwansa H, Roman RJ, Harder DR, Koehler RC) Am J Physiol Regul Integr Comp Physiol 2009 May;296(5):R1412-8 PMID: 19261918 PMCID: PMC2689832 SCOPUS ID: 2-s2.0-66149101990 03/06/2009 15 Citations

Astrocytes and the regulation of cerebral blood flow. (Koehler RC, Roman RJ, Harder DR) Trends Neurosci 2009 Mar;32(3):160-9 PMID: 19162338 SCOPUS ID: 2-s2.0-61649098367 01/24/2009 382 Citations

Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. (Boutet P, Agüera-González S, Atkinson S, Pennington CJ, Edwards DR, Murphy G, Reyburn HT, Valés-Gómez M) J Immunol 2009 Jan 01;182(1):49-53 PMID: 19109134 SCOPUS ID: 2-s2.0-59849101423 12/26/2008 126 Citations

Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. (Renic M, Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, Roman RJ) J Cereb Blood Flow Metab 2009 Mar;29(3):629-39 PMID: 19107134 PMCID: PMC2821901 SCOPUS ID: 2-s2.0-61349178515 12/25/2008 89 Citations

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. (Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ) Am J Physiol Heart Circ Physiol 2008 Dec;295(6):H2455-65 PMID: 18952718 PMCID: PMC2614536 SCOPUS ID: 2-s2.0-57349115247 10/28/2008 124 Citations

Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. (Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR) J Heart Lung Transplant 2008 Sep;27(9):1008-15 PMID: 18765194 PMCID: PMC2720038 SCOPUS ID: 2-s2.0-50249115531 09/04/2008 15 Citations

Increased blood pressure in mice lacking cytochrome P450 2J5. (Athirakul K, Bradbury JA, Graves JP, DeGraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Coffman TM, Zeldin DC) FASEB J 2008 Dec;22(12):4096-108 PMID: 18716027 PMCID: PMC2614614 SCOPUS ID: 2-s2.0-57349108805 08/22/2008 54 Citations

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. (Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H) J Clin Invest 2008 Sep;118(9):3025-37 PMID: 18688283 PMCID: PMC2496961 SCOPUS ID: 2-s2.0-51349157566 08/09/2008 206 Citations

Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. (Prasad VV, Nithipatikom K, Harder DR) Neurochem Int 2008 Dec;53(6-8):220-9 PMID: 18680775 SCOPUS ID: 2-s2.0-56349109857 08/06/2008 31 Citations

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. (Liu X, Li C, Falck JR, Roman RJ, Harder DR, Koehler RC) Am J Physiol Heart Circ Physiol 2008 Aug;295(2):H619-31 PMID: 18502903 PMCID: PMC2519225 SCOPUS ID: 2-s2.0-52449129583 05/27/2008 67 Citations

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. (Terashvili M, Tseng LF, Wu HE, Narayanan J, Hart LM, Falck JR, Pratt PF, Harder DR) J Pharmacol Exp Ther 2008 Aug;326(2):614-22 PMID: 18492947 PMCID: PMC2567871 SCOPUS ID: 2-s2.0-47949133301 05/22/2008 84 Citations

Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme. (Zagorac D, Jakovcevic D, Gebremedhin D, Harder DR) J Cereb Blood Flow Metab 2008 Aug;28(8):1431-9 PMID: 18414496 PMCID: PMC2637201 SCOPUS ID: 2-s2.0-48749116836 04/17/2008 35 Citations

Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. (Gebremedhin D, Yamaura K, Harder DR) Am J Physiol Heart Circ Physiol 2008 Jan;294(1):H107-20 PMID: 17906097 SCOPUS ID: 2-s2.0-38149009487 10/02/2007 53 Citations

(+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. (Terashvili M, Wu HE, Moore RM, Harder DR, Tseng LF) Eur J Pharmacol 2007 Sep 24;571(1):1-7 PMID: 17597599 PMCID: PMC3718891 SCOPUS ID: 2-s2.0-34548044285 06/29/2007 12 Citations

Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. (Shi Y, Liu X, Gebremedhin D, Falck JR, Harder DR, Koehler RC) J Cereb Blood Flow Metab 2008 Jan;28(1):111-25 PMID: 17519974 PMCID: PMC2204069 SCOPUS ID: 2-s2.0-37549048669 05/24/2007 69 Citations

Role of astrocytes in matching blood flow to neuronal activity. (Jakovcevic D, Harder DR) Curr Top Dev Biol 2007;79:75-97 PMID: 17498548 SCOPUS ID: 2-s2.0-34247868964 05/15/2007 71 Citations

Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution. (Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H895-901 PMID: 17434975 SCOPUS ID: 2-s2.0-34547129127 04/17/2007 20 Citations

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. (Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B) Free Radic Biol Med 2007 Apr 01;42(7):1049-61 PMID: 17349932 PMCID: PMC2692187 SCOPUS ID: 2-s2.0-33847619217 03/14/2007 87 Citations

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. (Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF) Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):19-29 PMID: 17164129 SCOPUS ID: 2-s2.0-33845313333 12/14/2006 47 Citations

Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes. (Yamaura K, Gebremedhin D, Zhang C, Narayanan J, Hoefert K, Jacobs ER, Koehler RC, Harder DR) Neuroscience 2006 Dec;143(3):703-16 PMID: 17027168 SCOPUS ID: 2-s2.0-33750978403 10/10/2006 46 Citations

Reactive oxygen species cerebral autoregulation in health and disease. (Terashvili M, Pratt PF, Gebremedhin D, Narayanan J, Harder DR) Pediatr Clin North Am 2006 Oct;53(5):1029-37, xi PMID: 17027622 PMCID: PMC2533262 SCOPUS ID: 2-s2.0-33749260560 10/10/2006 24 Citations

Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. (Hacein-Bey L, Harder DR, Meier HT, Varelas PN, Miyata N, Lauer KK, Cusick JF, Roman RJ) AJNR Am J Neuroradiol 2006;27(6):1350-4 PMID: 16775295 PMCID: PMC8133904 SCOPUS ID: 2-s2.0-33747387267 06/16/2006 34 Citations

Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease. (Iadecola C, Goldman SS, Harder DR, Heistad DD, Katusic ZS, Moskowitz MA, Simard JM, Sloan MA, Traystman RJ, Velletri PA) Stroke 2006 Jun;37(6):1578-81 PMID: 16627792 PMCID: PMC2730969 SCOPUS ID: 2-s2.0-33745141581 04/22/2006 32 Citations

Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. (Harder DR, Roman RJ) Circ Res 2006 Apr 14;98(7):866-7 PMID: 16614311 SCOPUS ID: 2-s2.0-33646145520 04/15/2006 4 Citations

Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. (Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yoshida S, Nakaike S, Okuyama S, Harder DR, Roman RJ) Stroke 2006 May;37(5):1307-13 PMID: 16601220 SCOPUS ID: 2-s2.0-33646707830 04/08/2006 65 Citations

Role of astrocytes in cerebrovascular regulation. (Koehler RC, Gebremedhin D, Harder DR) J Appl Physiol (1985) 2006 Jan;100(1):307-17 PMID: 16357084 PMCID: PMC1819408 SCOPUS ID: 2-s2.0-33644826760 12/17/2005 269 Citations

The effect of superoxide anion on autoregulation of cerebral blood flow. (Zagorac D, Yamaura K, Zhang C, Roman RJ, Harder DR) Stroke 2005 Dec;36(12):2589-94 PMID: 16293785 SCOPUS ID: 2-s2.0-33644665689 11/19/2005 35 Citations

Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH. (Takeuchi K, Miyata N, Renic M, Harder DR, Roman RJ) Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R84-9 PMID: 16166205 SCOPUS ID: 2-s2.0-33644833670 09/17/2005 19 Citations

Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE. (Takeuchi K, Renic M, Bohman QC, Harder DR, Miyata N, Roman RJ) Am J Physiol Heart Circ Physiol 2005 Nov;289(5):H2203-11 PMID: 15964920 SCOPUS ID: 2-s2.0-27144490317 06/21/2005 41 Citations

Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. (Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR, Roman RJ) J Pharmacol Exp Ther 2005 Jul;314(1):77-85 PMID: 15831442 SCOPUS ID: 2-s2.0-23044515393 04/16/2005 97 Citations

Mechanisms regulating cerebral blood flow as therapeutic targets. (Pratt PF, Medhora M, Harder DR) Curr Opin Investig Drugs 2004 Sep;5(9):952-6 PMID: 15503650 SCOPUS ID: 2-s2.0-13244257651 10/27/2004 32 Citations

Ca-induced Ca release: lessons regarding cell models. (Harder DR) Am J Physiol Heart Circ Physiol 2004 Nov;287(5):H1885-6 PMID: 15475522 SCOPUS ID: 2-s2.0-7244245400 10/12/2004 3 Citations

Ca-induced Ca release: lessons regarding cell models. (Harder DR) Am J Physiol Cell Physiol 2004 Nov;287(5):C1165-6 PMID: 15475514 SCOPUS ID: 2-s2.0-7244245400 10/12/2004 3 Citations

Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. (Drummond HA, Gebremedhin D, Harder DR) Hypertension 2004 Nov;44(5):643-8 PMID: 15381679 SCOPUS ID: 2-s2.0-7244260316 09/24/2004 155 Citations

Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats. (Peng X, Zhang C, Alkayed NJ, Harder DR, Koehler RC) J Cereb Blood Flow Metab 2004 May;24(5):509-17 PMID: 15129182 SCOPUS ID: 2-s2.0-2342656895 05/07/2004 74 Citations

Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. (Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy LM, Falck JR, Gebremedhin D, Harder DR, Roman RJ) Eur J Pharmacol 2004 Feb 23;486(3):297-306 PMID: 14985052 SCOPUS ID: 2-s2.0-10744221010 02/27/2004 60 Citations

Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. (Cambj-Sapunar L, Yu M, Harder DR, Roman RJ) Stroke 2003 May;34(5):1269-75 PMID: 12677022 SCOPUS ID: 2-s2.0-0038304402 04/05/2003 82 Citations

Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. (Bylund J, Harder AG, Maier KG, Roman RJ, Harder DR) Arch Biochem Biophys 2003 Apr 01;412(1):34-41 PMID: 12646265 SCOPUS ID: 2-s2.0-0037376494 03/21/2003 28 Citations

Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes. (Gebremedhin D, Yamaura K, Zhang C, Bylund J, Koehler RC, Harder DR) J Neurosci 2003 Mar 01;23(5):1678-87 PMID: 12629172 PMCID: PMC6741958 SCOPUS ID: 2-s2.0-0037335453 03/12/2003 76 Citations

Epoxyeicosatrienoic acids released by astrocytes: Function in cerebral angiogenesis (Zhang C. Harder DH) Excerpta Medica International Congress Series (ICS) 01/01/2003

Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. (Zhang C, Harder DR) Stroke 2002 Dec;33(12):2957-64 PMID: 12468797 SCOPUS ID: 2-s2.0-0036901546 12/07/2002 103 Citations

Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries. (Liu Y, Harder DR, Lombard JH) Am J Physiol Heart Circ Physiol 2002 Dec;283(6):H2276-81 PMID: 12388266 SCOPUS ID: 2-s2.0-0036890217 10/22/2002 24 Citations

Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. (Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, Harder DR) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H215-24 PMID: 12388259 SCOPUS ID: 2-s2.0-0037230201 10/22/2002 109 Citations

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. (Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC) Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H2029-37 PMID: 12384482 SCOPUS ID: 2-s2.0-0036838975 10/18/2002 107 Citations

Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (Bylund J, Zhang C, Harder DR) Biochem Biophys Res Commun 2002 Aug 23;296(3):677-84 PMID: 12176035 SCOPUS ID: 2-s2.0-0036384287 08/15/2002 44 Citations

Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. (Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, Hurn PD) Stroke 2002 Jun;33(6):1677-84 PMID: 12053011 SCOPUS ID: 2-s2.0-0036277938 06/08/2002 98 Citations

Mechanism of cGMP contribution to the vasodilator response to NO in rat middle cerebral arteries. (Yu M, Sun CW, Maier KG, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2002 May;282(5):H1724-31 PMID: 11959637 SCOPUS ID: 2-s2.0-0036087769 04/18/2002 43 Citations

20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. (Kehl F, Cambj-Sapunar L, Maier KG, Miyata N, Kametani S, Okamoto H, Hudetz AG, Schulte ML, Zagorac D, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2002 Apr;282(4):H1556-65 PMID: 11893593 SCOPUS ID: 2-s2.0-0036087904 03/15/2002 106 Citations

Astrocytes function in matching blood flow to metabolic activity. (Harder DR, Zhang C, Gebremedhin D) News Physiol Sci 2002 Feb;17:27-31 PMID: 11821533 SCOPUS ID: 2-s2.0-0036462415 02/01/2002 113 Citations

Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid. (Nithipatikom K, Grall AJ, Holmes BB, Harder DR, Falck JR, Campbell WB) Anal Biochem 2001 Nov 15;298(2):327-36 PMID: 11700990 SCOPUS ID: 2-s2.0-0035892637 11/10/2001 105 Citations

Prologue: EDHF--what is it? (Campbell WB, Harder DR) Am J Physiol Heart Circ Physiol 2001 Jun;280(6):H2413-6 PMID: 11356592 SCOPUS ID: 2-s2.0-0034979364 05/18/2001 51 Citations

Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids. (Roman RJ, Maier KG, Sun CW, Harder DR, Alonso-Galicia M) Clin Exp Pharmacol Physiol 2000 Nov;27(11):855-65 PMID: 11071299 SCOPUS ID: 2-s2.0-0033758628 11/09/2000 115 Citations

P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. (Bhardwaj A, Northington FJ, Carhuapoma JR, Falck JR, Harder DR, Traystman RJ, Koehler RC) Am J Physiol Heart Circ Physiol 2000 Oct;279(4):H1616-24 PMID: 11009448 SCOPUS ID: 2-s2.0-0033695239 09/29/2000 78 Citations

Impact factors and the competitive nature of journal publishing. (Harder DR) Am J Physiol Heart Circ Physiol 2000 Aug;279(2):H457 PMID: 10991631 SCOPUS ID: 2-s2.0-18144442552 09/19/2000 8 Citations

Impact factors and the competitive nature of journal publishing. (Harder DR) Am J Physiol Heart Circ Physiol 2000 Aug;279(2):H457-8 PMID: 10924041 08/03/2000

Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. (Sun CW, Falck JR, Okamoto H, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2000 Jul;279(1):H339-50 PMID: 10899074 SCOPUS ID: 2-s2.0-0033862805 07/19/2000 94 Citations

Production of 20-HETE and its role in autoregulation of cerebral blood flow. (Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, Harder DR) Circ Res 2000 Jul 07;87(1):60-5 PMID: 10884373 SCOPUS ID: 2-s2.0-0034617142 07/08/2000 292 Citations

Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes. (Harder DR, Roman RJ, Gebremedhin D) Acta Physiol Scand 2000 Apr;168(4):543-9 PMID: 10759591 SCOPUS ID: 2-s2.0-0034032372 04/12/2000 35 Citations

Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. (Munzenmaier DH, Harder DR) Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1163-7 PMID: 10749710 SCOPUS ID: 2-s2.0-0034109792 04/06/2000 129 Citations

Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. (Zhu D, Bousamra M 2nd, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2000 Feb;278(2):L335-43 PMID: 10666118 SCOPUS ID: 2-s2.0-0034014269 02/09/2000 90 Citations

Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation. (Alonso-Galicia M, Hudetz AG, Shen H, Harder DR, Roman RJ) Stroke 1999 Dec;30(12):2727-34; discussion 2734 PMID: 10583004 SCOPUS ID: 2-s2.0-0032728703 12/03/1999 82 Citations

Cytochrome P450 2C is an EDHF synthase in coronary arteries. (Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R) Nature 1999 Sep 30;401(6752):493-7 PMID: 10519554 SCOPUS ID: 2-s2.0-0033619262 10/16/1999 832 Citations

Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. (Gebremedhin D, Lange AR, Campbell WB, Hillard CJ, Harder DR) Am J Physiol 1999 Jun;276(6):H2085-93 PMID: 10362691 SCOPUS ID: 2-s2.0-0033002210 06/11/1999 251 Citations

Cerebrovascular alterations in protein kinase C-mediated constriction in stroke-prone rats. (Smeda JS, King S) Stroke 1999 Mar;30(3):656-61 PMID: 10066867 SCOPUS ID: 2-s2.0-0033006973 03/06/1999 10 Citations

Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. (Campbell WB, Harder DR) Circ Res 1999 Mar 05;84(4):484-8 PMID: 10066684 SCOPUS ID: 2-s2.0-0033525767 03/06/1999 193 Citations

Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. (Lombard JH, Kunert MP, Roman RJ, Falck JR, Harder DR, Jackson WF) Am J Physiol 1999 Feb;276(2):H503-8 PMID: 9950851 SCOPUS ID: 2-s2.0-0033036730 02/10/1999 39 Citations

Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. (Sun CW, Falck JR, Harder DR, Roman RJ) Hypertension 1999 Jan;33(1 Pt 2):414-8 PMID: 9931139 SCOPUS ID: 2-s2.0-0032946311 02/04/1999 114 Citations

A common pathway for regulation of nutritive blood flow to the brain: arterial muscle membrane potential and cytochrome P450 metabolites. (Harder DR, Roman RJ, Gebremedhin D, Birks EK, Lange AR) Acta Physiol Scand 1998 Dec;164(4):527-32 PMID: 9887975 SCOPUS ID: 2-s2.0-0032425022 01/15/1999 30 Citations

Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. (Sun CW, Alonso-Galicia M, Taheri MR, Falck JR, Harder DR, Roman RJ) Circ Res 1998 Nov 30;83(11):1069-79 PMID: 9831701 SCOPUS ID: 2-s2.0-0032583140 12/01/1998 164 Citations

Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. (Alonso-Galicia M, Sun CW, Falck JR, Harder DR, Roman RJ) Am J Physiol 1998 Sep;275(3):F370-8 PMID: 9729509 SCOPUS ID: 2-s2.0-0031702751 09/08/1998 91 Citations

Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. (Gebremedhin D, Harder DR, Pratt PF, Campbell WB) J Vasc Res 1998;35(4):274-84 PMID: 9701712 SCOPUS ID: 2-s2.0-0031819649 08/14/1998 89 Citations

Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs. (Zhu D, Effros RM, Harder DR, Roman RJ, Jacobs ER) Am J Respir Cell Mol Biol 1998 Jul;19(1):121-8 PMID: 9651188 SCOPUS ID: 2-s2.0-0032111675 07/03/1998 41 Citations

Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. (Gebremedhin D, Lange AR, Narayanan J, Aebly MR, Jacobs ER, Harder DR) J Physiol 1998 Mar 15;507 ( Pt 3)(Pt 3):771-81 PMID: 9508838 PMCID: PMC2230829 SCOPUS ID: 2-s2.0-0032521122 05/23/1998 183 Citations

Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites. (Harder DR, Alkayed NJ, Lange AR, Gebremedhin D, Roman RJ) Stroke 1998 Jan;29(1):229-34 PMID: 9445355 SCOPUS ID: 2-s2.0-0031963859 01/28/1998 199 Citations

Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. (Alkayed NJ, Birks EK, Narayanan J, Petrie KA, Kohler-Cabot AE, Harder DR) Stroke 1997 May;28(5):1066-72 PMID: 9158651 SCOPUS ID: 2-s2.0-0030965729 05/01/1997 129 Citations

Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. (Harder DR, Lange AR, Gebremedhin D, Birks EK, Roman RJ) J Vasc Res 1997;34(3):237-43 PMID: 9226306 SCOPUS ID: 2-s2.0-0031002404 05/01/1997 152 Citations

Symposium on potassium channels in blood vessels (Heistad DD, Harder DR) Clinical Experimental Pharmacology Physiology 01/01/1997

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow. (Alkayed NJ, Birks EK, Hudetz AG, Roman RJ, Henderson L, Harder DR) Am J Physiol 1996 Oct;271(4 Pt 2):H1541-6 PMID: 8897950 SCOPUS ID: 2-s2.0-33750807720 10/01/1996 106 Citations

Identification of a putative microvascular oxygen sensor. (Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, Roman RJ) Circ Res 1996 Jul;79(1):54-61 PMID: 8925569 SCOPUS ID: 2-s2.0-0029947046 07/01/1996 178 Citations

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. (Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR) Stroke 1996 May;27(5):971-9 PMID: 8623121 SCOPUS ID: 2-s2.0-0029930387 05/01/1996 182 Citations

Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. (Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1996 May;270(5 Pt 2):F822-32 PMID: 8928844 SCOPUS ID: 2-s2.0-0029888211 05/01/1996 195 Citations

Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. (Campbell WB, Gebremedhin D, Pratt PF, Harder DR) Circ Res 1996 Mar;78(3):415-23 PMID: 8593700 SCOPUS ID: 2-s2.0-0030051805 03/01/1996 1145 Citations

Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. (Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):R217-27 PMID: 8769805 SCOPUS ID: 2-s2.0-0030028233 01/01/1996 268 Citations

Coexistence of two types of Ca(2+)-activated K+ channels in rat renal arterioles. (Gebremedhin D, Kaldunski M, Jacobs ER, Harder DR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):F69-81 PMID: 8769824 SCOPUS ID: 2-s2.0-0030062899 01/01/1996 91 Citations

20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. (Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):R228-37 PMID: 8769806 SCOPUS ID: 2-s2.0-0030029461 01/01/1996 295 Citations

Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells. (Jacobs ER, Cheliakine C, Gebremedhin D, Birks EK, Davies PF, Harder DR) Pflugers Arch 1995 Nov;431(1):129-31 PMID: 8584410 SCOPUS ID: 2-s2.0-0028840911 11/01/1995 77 Citations

Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. (Harder DR, Campbell WB, Roman RJ) J Vasc Res 1995;32(2):79-92 PMID: 7537544 SCOPUS ID: 2-s2.0-0028904786 03/01/1995 281 Citations

Transduction of physical force by the vascular wall Role of phospholipase C and cytochrome P450 metabolites of arachidonic acid. (Harder DR, Narayanan J, Gebremedhin D, Roman RJ) Trends Cardiovasc Med 1995;5(1):7-14 PMID: 21232232 SCOPUS ID: 2-s2.0-0028952938 01/01/1995 45 Citations

Hypoxia increases the activity of Ca(2+)-sensitive K+ channels in cat cerebral arterial muscle cell membranes. (Gebremedhin D, Bonnet P, Greene AS, England SK, Rusch NJ, Lombard JH, Harder DR) Pflugers Arch 1994 Oct;428(5-6):621-30 PMID: 7838685 SCOPUS ID: 2-s2.0-0028088792 10/01/1994 99 Citations

Myogenic activation of canine small renal arteries after nonchemical removal of the endothelium. (Liu Y, Harder DR, Lombard JH) Am J Physiol 1994 Jul;267(1 Pt 2):H302-7 PMID: 8048595 SCOPUS ID: 2-s2.0-0027967024 07/01/1994 50 Citations

Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats. (Li P, Zou AP, al-Kayed NJ, Rusch NJ, Harder DR) Hypertension 1994 Jun;23(6 Pt 2):914-8 PMID: 8206627 SCOPUS ID: 2-s2.0-0028214040 06/01/1994 25 Citations

Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. (Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman R) Am J Physiol 1994 May;266(5 Pt 2):H2098-107 PMID: 8203608 SCOPUS ID: 2-s2.0-0028155755 05/01/1994 240 Citations

Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol. (Narayanan J, Imig M, Roman RJ, Harder DR) Am J Physiol 1994 May;266(5 Pt 2):H1840-5 PMID: 8203583 SCOPUS ID: 2-s2.0-0028066620 05/01/1994 105 Citations

Cellular and ionic signal transduction mechanisms for the mechanical activation of renal arterial vascular smooth muscle. (Roman RJ, Harder DR) J Am Soc Nephrol 1993 Oct;4(4):986-96 PMID: 7506944 SCOPUS ID: 2-s2.0-0027675123 10/01/1993 38 Citations

Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. (Imig JD, Falck JR, Gebremedhin D, Harder DR, Roman RJ) Hypertension 1993 Sep;22(3):357-64 PMID: 8349328 SCOPUS ID: 2-s2.0-0027301319 09/01/1993 111 Citations

[Pulmonary valve endocarditis and atrial fibrillation]. (Harder D, Ehses W, Weller P, Deuss U, Winkelmann W) Dtsch Med Wochenschr 1993 Jul 02;118(26):975-8 PMID: 8519232 SCOPUS ID: 2-s2.0-0027300495 07/02/1993 1 Citation

Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli. (Masters BS, Clark JE, Roman LJ, Nishimoto M, McCabe TJ, Ortiz de Montellano PR, Plopper CG, Gebremedhin D, Ma YH, Harder DR) J Lipid Mediat 1993;6(1-3):353-60 PMID: 8357994 SCOPUS ID: 2-s2.0-0026969309 03/01/1993 11 Citations

Influence of physical and environmental factors on ion channels in arterial muscle (Harder DR, Gebremedhin D, Roman RJ) Ion Flux in Pulmonary Vascular Control 01/04/1993

20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. (Ma YH, Gebremedhin D, Schwartzman ML, Falck JR, Clark JE, Masters BS, Harder DR, Roman RJ) Circ Res 1993 Jan;72(1):126-36 PMID: 8417836 SCOPUS ID: 2-s2.0-0027329156 01/01/1993 257 Citations

Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. (Gebremedhin D, Ma YH, Imig JD, Harder DR, Roman RJ) J Vasc Res 1993;30(1):53-60 PMID: 8435472 SCOPUS ID: 2-s2.0-0027471234 01/01/1993 56 Citations

Modulation of vascular tone in renal microcirculation by erythrocytes: role of EDRF. (Imig JD, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1993 Jan;264(1 Pt 2):H190-5 PMID: 8430846 SCOPUS ID: 2-s2.0-0027404794 01/01/1993 40 Citations

An angiographic method for in vivo study of arteries of the circle of Willis in small animals. (Harder DR, Schulte ML, Clough AV, Dawson CA) Am J Physiol 1992 Nov;263(5 Pt 2):H1616-22 PMID: 1443212 SCOPUS ID: 2-s2.0-0026464492 11/01/1992 9 Citations

Distensibility of small veins of the dog lung. (al-Tinawi A, Clough AV, Harder DR, Linehan JH, Rickaby DA, Dawson CA) J Appl Physiol (1985) 1992 Nov;73(5):2158-65 PMID: 1474098 SCOPUS ID: 2-s2.0-0026469837 11/01/1992 12 Citations

Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. (Gebremedhin D, Ma YH, Falck JR, Roman RJ, VanRollins M, Harder DR) Am J Physiol 1992 Aug;263(2 Pt 2):H519-25 PMID: 1510149 SCOPUS ID: 2-s2.0-0026758963 08/01/1992 290 Citations

Non-invasive determination of systolic blood pressure by heart sound pattern analysis. (Bartels A, Harder D) Clin Phys Physiol Meas 1992 Aug;13(3):249-56 PMID: 1424474 SCOPUS ID: 2-s2.0-0026737395 08/01/1992 30 Citations

Spontaneous flow oscillations in the cerebral cortex during acute changes in mean arterial pressure. (Hudetz AG, Roman RJ, Harder DR) J Cereb Blood Flow Metab 1992 May;12(3):491-9 PMID: 1569142 SCOPUS ID: 2-s2.0-0026514971 05/01/1992 126 Citations

Performance on multiple choice/short answer tests is not a sufficient criterion for evaluating the educational value of live animal laboratories in the teaching of physiology. (Dawson CA, Cowley AW Jr, Spurr GB, Osborn JL, Raff H, Forster HV, Harder DR, Liard JF, Lombard JH, Stekiel WJ) Am J Physiol 1991 Dec;261(6 Pt 3):S34-5 PMID: 1755480 SCOPUS ID: 2-s2.0-0026284575 12/11/1991 4 Citations

Distensibility of small arteries of the dog lung. (al-Tinawi A, Madden JA, Dawson CA, Linehan JH, Harder DR, Rickaby DA) J Appl Physiol (1985) 1991 Nov;71(5):1714-22 PMID: 1761466 SCOPUS ID: 2-s2.0-0026043296 11/01/1991 26 Citations

Effects of 12-HETE on isolated dog renal arcuate arteries. (Ma YH, Harder DR, Clark JE, Roman RJ) Am J Physiol 1991 Aug;261(2 Pt 2):H451-6 PMID: 1908641 SCOPUS ID: 2-s2.0-0026050962 08/01/1991 62 Citations

Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. (Kauser K, Clark JE, Masters BS, Ortiz de Montellano PR, Ma YH, Harder DR, Roman RJ) Circ Res 1991 Apr;68(4):1154-63 PMID: 1901255 SCOPUS ID: 2-s2.0-0025967421 04/01/1991 134 Citations

Characterization of an outward K+ current in freshly dispersed cerebral arterial muscle cells. (Bonnet P, Rusch NJ, Harder DR) Pflugers Arch 1991 Apr;418(3):292-6 PMID: 1857636 SCOPUS ID: 2-s2.0-0025882108 04/01/1991 62 Citations

Cellular and biochemical mechanisms of pressure-induced myogenic tone in arteries (Harder DR, Roman RJ, Lombard JH) Resistance Arteries, Structure and Function: Excerpta Medica 01/07/1991

Structure-function studies and physiological roles of eicosanoids metabolized by cytochrome P450 w-Hydroxylases (Masters BSS, Clark JE, Roman LJ, McCabe TJ, Helm CB, Johnson EF, Ma Y-H, Harder DR, Roman RJ ) Prostaglandins, Leukotrienes, Lipoxins and PAF 01/07/1991

Effects of hypoxia on a potassium channel in cat cerebral arterial muscle cells. (Bonnet P, Gebremedhin D, Rush NJ, Harder DR) Z Kardiol 1991;80 Suppl 7:25-7 PMID: 1792816 SCOPUS ID: 2-s2.0-0026327010 01/01/1991 13 Citations

Enhanced vascular tone in the renal vasculature of spontaneously hypertensive rats. (Gebremedhin D, Fenoy FJ, Harder DR, Roman RJ) Hypertension 1990 Dec;16(6):648-54 PMID: 2246032 SCOPUS ID: 2-s2.0-0025685382 12/01/1990 53 Citations

Effect of nifedipine on endothelin induced contractions of skeletal muscle arterioles of spontaneously hypertensive rats. (Lougee L, Hinojosa-Laborde C, Harder DR, Lombard JH) Microcirc Endothelium Lymphatics 1990;6(4-5):355-68 PMID: 2280745 SCOPUS ID: 2-s2.0-0025205012 08/01/1990 4 Citations

Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure. (Lombard JH, Eskinder H, Kauser K, Osborn JL, Harder DR) Am J Physiol 1990 Jul;259(1 Pt 2):H29-33 PMID: 2375412 SCOPUS ID: 2-s2.0-0024991327 07/01/1990 47 Citations

Role of the vascular endothelium in regulating the response of small arteries of the dog kidney to transmural pressure elevation and reduced PO2. (Eskinder H, Harder DR, Lombard JH) Circ Res 1990 May;66(5):1427-35 PMID: 2335035 SCOPUS ID: 2-s2.0-0025265303 05/01/1990 38 Citations

Mechanoreception by the endothelium: mediators and mechanisms of pressure- and flow-induced vascular responses. (Rubanyi GM, Freay AD, Kauser K, Johns A, Harder DR) Blood Vessels 1990;27(2-5):246-57 PMID: 2242445 SCOPUS ID: 2-s2.0-0025049276 01/01/1990 168 Citations

Endothelium-dependent modulation of endothelin-induced vasoconstriction and membrane depolarization in cat cerebral arteries. (Kauser K, Rubanyi GM, Harder DR) J Pharmacol Exp Ther 1990 Jan;252(1):93-7 PMID: 2405153 SCOPUS ID: 2-s2.0-0025020417 01/01/1990 50 Citations

Mechanisms of pressure-induced myogenic activation of cerebral and renal arteries: role of the endothelium. (Harder DR, Kauser K, Roman RJ, Lombard JH) J Hypertens Suppl 1989 Sep;7(4):S11-5; discussion S16 PMID: 2809804 SCOPUS ID: 2-s2.0-0024376582 09/01/1989 26 Citations

[Lymphomatoid papulosis resembling ecthyma. A case report]. (Harder D, Kuhn A, Mahrle G) Z Hautkr 1989 Jul 15;64(7):593-5 PMID: 2528243 SCOPUS ID: 2-s2.0-0024384346 07/15/1989 1 Citation

Pressure releases a transferable endothelial contractile factor in cat cerebral arteries. (Harder DR, Sanchez-Ferrer C, Kauser K, Stekiel WJ, Rubanyi GM) Circ Res 1989 Jul;65(1):193-8 PMID: 2661050 SCOPUS ID: 2-s2.0-0024401081 07/01/1989 64 Citations

Mechanism of action of EDRF on pressurized arteries: effect on K+ conductance. (Kauser K, Stekiel WJ, Rubanyi G, Harder DR) Circ Res 1989 Jul;65(1):199-204 PMID: 2786773 SCOPUS ID: 2-s2.0-0024322480 07/01/1989 52 Citations

Pressure-dependent contraction of rat juxtamedullary afferent arterioles. (Sanchez-Ferrer CF, Roman RJ, Harder DR) Circ Res 1989 Apr;64(4):790-8 PMID: 2702737 SCOPUS ID: 2-s2.0-0024556306 04/01/1989 62 Citations

Increased sensitivity of cat cerebral arteries to serotonin upon elevation of transmural pressure. (Harder DR) Pflugers Arch 1988 Jun;411(6):698-700 PMID: 3412871 SCOPUS ID: 2-s2.0-0023936795 06/01/1988 24 Citations

Early effects of experimental diabetes on central catecholamine concentrations. (Wesselmann U, Konkol RJ, Roerig DL, Harder DR) Brain Res Bull 1988 May;20(5):651-4 PMID: 3133085 SCOPUS ID: 2-s2.0-0024162567 05/01/1988 10 Citations

Vascular muscle cell depolarization and activation in renal arteries on elevation of transmural pressure. (Harder DR, Gilbert R, Lombard JH) Am J Physiol 1987 Oct;253(4 Pt 2):F778-81 PMID: 2444115 SCOPUS ID: 2-s2.0-0023623683 10/01/1987 147 Citations

Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog. (Harder DR, Dernbach P, Waters A) J Clin Invest 1987 Sep;80(3):875-80 PMID: 2957393 PMCID: PMC442315 SCOPUS ID: 2-s2.0-0023473459 09/01/1987 109 Citations

Electrical stimulation of the endothelial surface of pressurized cat middle cerebral artery results in TTX-sensitive vasoconstriction. (Harder DR, Madden JA) Circ Res 1987 Jun;60(6):831-6 PMID: 3594755 SCOPUS ID: 2-s2.0-0023222815 06/01/1987 8 Citations

Distribution of excitatory junction potential amplitude in cat cerebral arteries: examination of its quantal nature and modulation by opiates. (Madden JA, Kalbfleisch JH, Harder DR) J Cell Physiol 1987 May;131(2):262-6 PMID: 2438292 SCOPUS ID: 2-s2.0-0023220514 05/01/1987 3 Citations

Altered splenic catecholamine concentrations during experimental allergic encephalomyelitis. (Wesselmann U, Konkol RJ, Leo GL, Roerig DL, Harder DR) Pharmacol Biochem Behav 1987 Apr;26(4):851-4 PMID: 3110796 SCOPUS ID: 2-s2.0-0023323846 04/01/1987 11 Citations

The effect of alkaline pH and transmural pressure on arterial constriction and membrane potential of hypertensive cerebral arteries. (Smeda JS, Lombard JH, Madden JA, Harder DR) Pflugers Arch 1987 Mar;408(3):239-42 PMID: 3106928 SCOPUS ID: 2-s2.0-0023148633 03/01/1987 18 Citations

Effect of morphine on electrophysiological properties of circular and longitudinal muscles. (Gilbert RJ, Sarna SK, Harder DR) Am J Physiol 1987 Mar;252(3 Pt 1):G333-8 PMID: 3826373 SCOPUS ID: 2-s2.0-0023274281 03/01/1987 2 Citations

Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium. (Harder DR) Circ Res 1987 Jan;60(1):102-7 PMID: 3568282 SCOPUS ID: 2-s2.0-0023113971 01/01/1987 196 Citations

Effect of reduced oxygen availability upon myogenic depolarization and contraction of cat middle cerebral artery. (Lombard JH, Smeda J, Madden JA, Harder DR) Circ Res 1986 Apr;58(4):565-9 PMID: 3698219 SCOPUS ID: 2-s2.0-0022602689 04/01/1986 29 Citations

Electrophysiological mechanisms of arterial muscle activation: alterations associated with cerebral vasospasm and hypertension. (Harder DR) Prog Clin Biol Res 1986;219:245-63 PMID: 3538027 SCOPUS ID: 2-s2.0-0022436921 01/01/1986 4 Citations

Vascular smooth muscle transmembrane potentials during hypotensive stress. (Lombard JH, Willems WJ, Harder DR, Stekiel WJ) Circ Shock 1986;18(2):131-40 PMID: 3948338 SCOPUS ID: 2-s2.0-0022638782 01/01/1986 2 Citations

Vascular smooth muscle membrane potentials in rats with one-kidney, one clip and reduced renal mass-saline hypertension: the influence of a humoral sodium pump inhibitor. (Pamnani MB, Bryant HJ, Harder DR, Haddy FJ) J Hypertens Suppl 1985 Dec;3(3):S29-31 PMID: 2856822 SCOPUS ID: 2-s2.0-0022283284 12/01/1985 7 Citations

Altered membrane properties of cerebral vascular smooth muscle following subarachnoid hemorrhage: an electrophysiological study. I. Changes in resting membrane potential (Em) and effect on the electrogenic pump potential contribution to Em. (Waters A, Harder DR) Stroke 1985;16(6):990-7 PMID: 2418549 SCOPUS ID: 2-s2.0-0022349610 11/01/1985 50 Citations

Hypoxic induction of Ca2+-dependent action potentials in small pulmonary arteries of the cat. (Harder DR, Madden JA, Dawson C) J Appl Physiol (1985) 1985 Nov;59(5):1389-93 PMID: 4066569 SCOPUS ID: 2-s2.0-0022273597 11/01/1985 80 Citations

A membrane electrical mechanism for hypoxic vasoconstriction of small pulmonary arteries from cat. (Harder DR, Madden JA, Dawson C) Chest 1985 Oct;88(4 Suppl):233S-235S PMID: 3930164 SCOPUS ID: 2-s2.0-0022203366 10/01/1985 28 Citations

Enhanced myogenic depolarization in hypertensive cerebral arterial muscle. (Harder DR, Smeda J, Lombard J) Circ Res 1985 Aug;57(2):319-22 PMID: 4017200 SCOPUS ID: 2-s2.0-0021853601 08/01/1985 75 Citations

Hypoxia-induced activation in small isolated pulmonary arteries from the cat. (Madden JA, Dawson CA, Harder DR) J Appl Physiol (1985) 1985 Jul;59(1):113-8 PMID: 4030552 SCOPUS ID: 2-s2.0-0022362903 07/01/1985 153 Citations

In vivo membrane potentials of smooth muscle cells in the caudal artery of the rat. (Bryant HJ, Harder DR, Pamnani MB, Haddy FJ) Am J Physiol 1985 Jul;249(1 Pt 1):C78-83 PMID: 4014453 SCOPUS ID: 2-s2.0-0022415282 07/01/1985 12 Citations

Cellular actions of halothane on cat cerebral arterial muscle. (Harder DR, Gradall K, Madden JA, Kampine JP) Stroke 1985;16(4):680-3 PMID: 4024180 SCOPUS ID: 2-s2.0-0021864113 07/01/1985 10 Citations

Cellular mechanism of force development in cat middle cerebral artery by reduced PCO2. (Harder DR, Madden JA) Pflugers Arch 1985 Apr;403(4):402-6 PMID: 3925432 SCOPUS ID: 2-s2.0-0021939950 04/01/1985 51 Citations

A cellular mechanism for myogenic regulation of cat cerebral arteries. (Harder DR) Ann Biomed Eng 1985;13(3-4):335-9 PMID: 4037463 SCOPUS ID: 2-s2.0-0021849929 01/01/1985 15 Citations

Pressure-dependent membrane depolarization in cat middle cerebral artery. (Harder DR) Circ Res 1984 Aug;55(2):197-202 PMID: 6744529 SCOPUS ID: 2-s2.0-0021182202 08/01/1984 337 Citations

Cellular mechanisms of opiate receptor stimulation in cat middle cerebral artery. (Harder DR, Madden JA) Eur J Pharmacol 1984 Jul 20;102(3-4):411-6 PMID: 6092096 SCOPUS ID: 2-s2.0-0021267604 07/20/1984 23 Citations

Electrical activation of arterial muscle. (Harder DR, Waters A) Int Rev Cytol 1984;89:137-49 PMID: 6088415 SCOPUS ID: 2-s2.0-0021285366 01/01/1984 7 Citations

Electromechanical coupling in rat basilar artery in response to morphine. (Waters A, Harder DR) Neurosurgery 1983 Dec;13(6):676-80 PMID: 6657022 SCOPUS ID: 2-s2.0-0021087602 12/01/1983 15 Citations

Electromechanical coupling in feline basilar artery in response to serotonin. (Harder DR, Waters A) Eur J Pharmacol 1983 Sep 16;93(1-2):95-100 PMID: 6628550 SCOPUS ID: 2-s2.0-0020524805 09/16/1983 23 Citations

Membrane mechanisms in arterial hypertension. (Harder DR, Hermsmeyer K) Hypertension 1983;5(4):404-8 PMID: 6345356 SCOPUS ID: 2-s2.0-0020538112 07/01/1983 32 Citations

Sodium-potassium pump activity in reduced renal-mass hypertension. (Huot SJ, Pamnani MB, Clough DL, Buggy J, Bryant HJ, Harder DR, Haddy FJ) Hypertension 1983;5(2 Pt 2):I94-100 PMID: 6298108 SCOPUS ID: 2-s2.0-0342731038 03/01/1983 62 Citations

Response of venous membrane potentials to calcium blockade in spontaneous hypertension. (Stekiel WJ, Contney SJ, Lombard JH, Harder DR) Hypertension 1983;5(2 Pt 2):I64-9 PMID: 6826229 SCOPUS ID: 2-s2.0-0020682928 03/01/1983 1 Citation

Heterogeneity of membrane properties in vascular muscle cells from various vascular beds. (Harder DR) Fed Proc 1983 Feb;42(2):253-6 PMID: 6337065 SCOPUS ID: 2-s2.0-0020513922 02/01/1983 23 Citations

Diatrizoate meglumine-induced dilation of rat basilar artery: an in vitro study. (Schmidek HH, Moreira D, Harder DR) Neurosurgery 1983 Feb;12(2):137-41 PMID: 6835495 SCOPUS ID: 2-s2.0-0020699527 02/01/1983 6 Citations

Altered membrane electrical properties of smooth muscle cells from small cerebral arteries of hypertensive rats. (Harder DR, Brann L, Halpern W) Blood Vessels 1983;20(3):154-60 PMID: 6831059 SCOPUS ID: 2-s2.0-0020583247 01/01/1983 51 Citations

Sympathetic supraspinal control of venous membrane potential in spontaneous hypertension in vivo. (Willems WJ, Harder DR, Contney SJ, McCubbin JW, Stekiel WJ) Am J Physiol 1982 Sep;243(3):C101-6 PMID: 7114244 SCOPUS ID: 2-s2.0-0020189433 09/01/1982 13 Citations

Effect of H+ and elevated PCO2 on membrane electrical properties of rat cerebral arteries. (Harder DR) Pflugers Arch 1982 Aug;394(2):182-5 PMID: 6812018 SCOPUS ID: 2-s2.0-0019950492 08/01/1982 36 Citations

Effect of methylprednisolone on small vein responses to hemorrhage and norepinephrine. (Harder DR, Stekiel WJ, Lombard JH) Eur J Pharmacol 1982 Jun 16;81(1):163-6 PMID: 7117368 SCOPUS ID: 2-s2.0-0019966813 06/16/1982 3 Citations

Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine. (Harder DR, Abel PW, Hermsmeyer K) Circ Res 1981 Dec;49(6):1237-42 PMID: 7307242 SCOPUS ID: 2-s2.0-0019852057 12/01/1981 28 Citations

Bepridil blockade of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery. (Harder DR, Sperelakis N) J Cardiovasc Pharmacol 1981;3(4):906-14 PMID: 6167820 SCOPUS ID: 2-s2.0-0019390650 07/01/1981 51 Citations

Norepinephrine effect on in situ venous membrane potential in spontaneously hypertensive rats. (Harder DR, Contney SJ, Willems WJ, Stekiel WJ) Am J Physiol 1981 Jun;240(6):H837-42 PMID: 7246748 SCOPUS ID: 2-s2.0-0019583681 06/01/1981 18 Citations

Membrane activation of smooth muscle from rabbit basilar artery by dopamine. (Harder DR) Pflugers Arch 1981 Jun;390(3):296-8 PMID: 7196031 SCOPUS ID: 2-s2.0-0019427194 06/01/1981 7 Citations

Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries. (Harder DR, Belardinelli L) Experientia 1980 Sep 15;36(9):1082-3 PMID: 7418845 SCOPUS ID: 2-s2.0-0019310055 09/15/1980 18 Citations

Transmembrane potential and amino acid transport in rat hepatocytes in primary monolayer culture. (Wondergem R, Harder DR) J Cell Physiol 1980 Jul;104(1):53-60 PMID: 7440646 SCOPUS ID: 2-s2.0-0019271976 07/01/1980 21 Citations

Comparison of electrical properties of middle cerebral and mesenteric artery in cat. (Harder DR) Am J Physiol 1980 Jul;239(1):C23-6 PMID: 7395983 SCOPUS ID: 2-s2.0-0019036221 07/01/1980 47 Citations

Membrane electrical effects of histamine on vascular smooth muscle of canine coronary artery. (Harder DR) Circ Res 1980 Mar;46(3):372-7 PMID: 7357692 SCOPUS ID: 2-s2.0-0018843703 03/01/1980 13 Citations

Membrane potential measurements during rat liver regeneration. (Wondergem R, Harder DR) J Cell Physiol 1980 Feb;102(2):193-7 PMID: 7372723 SCOPUS ID: 2-s2.0-0018826199 02/01/1980 24 Citations

Active vascular smooth muscle tone and venous membrane potentials during hemorrhage. (Stekiel WJ, Willems WJ, Harder DR, Lombard JH) Am J Physiol 1980 Feb;238(2):H144-52 PMID: 7361906 SCOPUS ID: 2-s2.0-0018978235 02/01/1980 9 Citations

Estrogen receptors and effects of estrogen on membrane electrical properties of coronary vascular smooth muscle. (Harder DR, Coulson PB) J Cell Physiol 1979 Aug;100(2):375-82 PMID: 511949 SCOPUS ID: 2-s2.0-0018617333 08/01/1979 173 Citations

Action potentials induced in guinea pig arterial smooth muscle by tetraethylammonium. (Harder DR, Sperelakis N) Am J Physiol 1979 Jul;237(1):C75-80 PMID: 464044 SCOPUS ID: 2-s2.0-17744417865 07/01/1979 34 Citations

Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. (Harder DR, Belardinelli L, Sperelakis N, Rubio R, Berne RM) Circ Res 1979 Feb;44(2):176-82 PMID: 104800 02/01/1979

Action potential generation in reaggregates of rat aortic smooth muscle cells in primary culture. (Harder DR, Sperelakis N) Blood Vessels 1979;16(4):186-201 PMID: 454857 SCOPUS ID: 2-s2.0-0018769229 01/01/1979 20 Citations

Membrane electrical properties of vascular smooth muscle from the guinea pig superior mesenteric artery. (Harder DR, Sperelakis N) Pflugers Arch 1978 Dec 28;378(2):111-9 PMID: 569831 SCOPUS ID: 2-s2.0-0018068756 12/28/1978 48 Citations

[Antigens of the connective tissue. I. Studies of serum proteins in connective tissue]. (Timpl R, Pecker I) Z Immunitatsforsch Allerg Klin Immunol 1967 Apr;132(4):322-34 PMID: 4232417 SCOPUS ID: 2-s2.0-0014076448 04/01/1967 1 Citation

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

David Harder PhD, MS

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Publications (207)