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Medical College of Wisconsin

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Demin Wang PhD

Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center
Member of the Center for Immunology
Member of the Center for Microbiome Research

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Publications (122)

DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation. (Koo AS, Jia W, Kim S, Scalf M, Boos CE, Chen Y, Wang D, Voter AF, Bajaj A, Smith LM, Keck JL, Bakkenist CJ, Guo L, Tibbetts RS) bioRxiv 2025 May 28 PMID: 39553946 PMCID: PMC11565852 11/18/2024

Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19. (Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z) Res Pract Thromb Haemost 2023 Aug;7(6):102164 PMID: 37680312 PMCID: PMC10480648 SCOPUS ID: 2-s2.0-85169507694 09/08/2023 6 Citations

MiR-9-1 controls osteoblastic regulation of lymphopoiesis. (Zhang Y, Lin D, Zheng Y, Chen Y, Yu M, Cui D, Huang M, Su X, Sun Y, Chen Y, Qian Z, Carlson KS, Wen R, Wang D) Leukemia 2023 Nov;37(11):2261-2275 PMID: 37670087 PMCID: PMC10844005 SCOPUS ID: 2-s2.0-85169811460 09/06/2023 5 Citations

Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19 (Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z) Research and Practice in Thrombosis and Haemostasis August 2023;7(6) SCOPUS ID: 2-s2.0-85169507694 08/01/2023 6 Citations

CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells. (Zheng Y, Yu M, Chen Y, Xue L, Zhu W, Fu G, Morris SW, Wen R, Wang D) J Immunol 2023 May 01;210(9):1222-1235 PMID: 36961449 PMCID: PMC10156913 SCOPUS ID: 2-s2.0-85152627989 03/25/2023 2 Citations

Monoclonal gammopathy of thrombotic/thrombocytopenic significance. (Kanack AJ, Schaefer JK, Sridharan M, Splinter NP, Kohlhagen MC, Singh B, De Lorenzo SB, Mauch EE, Hussein MA, Shaikh M, Kumar S, Wen R, Wang D, Murray D, Padmanabhan A) Blood 2023 Apr 06;141(14):1772-1776 PMID: 36626584 PMCID: PMC10113173 SCOPUS ID: 2-s2.0-85149641390 01/11/2023 28 Citations

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis. (Zhu W, Zheng Y, Yu M, Wu Y, Wei J, Zhou L, Fu G, Schneider N, Jones C, Irani M, Padmanabhan A, Aster R, Wang D, Wen R) Blood 2023 Mar 02;141(9):1060-1069 PMID: 36493339 PMCID: PMC10023725 SCOPUS ID: 2-s2.0-85147273278 12/10/2022 5 Citations

MCD-DLBCL arises from germinal center B cells. (Wen R, Wang D) Blood 2022 Sep 08;140(10):1058-1059 PMID: 36074533 PMCID: PMC9461468 SCOPUS ID: 2-s2.0-85137324355 09/09/2022 4 Citations

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT. (Kanack AJ, Bayas A, George G, Abou-Ismail MY, Singh B, Kohlhagen MC, Splinter NP, Christ M, Naumann M, Moser KA, Smock KJ, Grazioli A, Wen R, Wang D, Murray DL, Padmanabhan A) Blood 2022 Jul 07;140(1):73-77 PMID: 35560046 PMCID: PMC9262283 SCOPUS ID: 2-s2.0-85133918941 05/14/2022 49 Citations

Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis. (Bluemn T, Schmitz J, Zheng Y, Burns R, Zheng S, DeJong J, Christiansen L, Arnold O, Izaguirre-Carbonell J, Wang D, Deshpande AJ, Zhu N) Leukemia 2022 Apr;36(4):946-955 PMID: 35022500 PMCID: PMC10095935 SCOPUS ID: 2-s2.0-85122690302 01/14/2022 14 Citations

STAT5B, the dominant twin, in hematopoietic stem cells (Chen Y, Wang D) Blood 9 December 2021;138(23):2303-2305 SCOPUS ID: 2-s2.0-85120728825 12/09/2021

LncRNA00492 is required for marginal zone B-cell development. (Wang F, Cui D, Zhang Q, Shao Y, Zheng B, Chen L, Luo Y, Yuan L, Wang D) Immunology 2022 Jan;165(1):88-98 PMID: 34435359 SCOPUS ID: 2-s2.0-85114376236 08/27/2021 5 Citations

Immune cells surveil aberrantly sialylated O-glycans on megakaryocytes to regulate platelet count. (Lee-Sundlov MM, Burns RT, Kim TO, Grozovsky R, Giannini S, Rivadeneyra L, Zheng Y, Glabere SH, Kahr WHA, Abdi R, Despotovic JM, Wang D, Hoffmeister KM) Blood 2021 Dec 09;138(23):2408-2424 PMID: 34324649 PMCID: PMC8662070 SCOPUS ID: 2-s2.0-85120725620 07/30/2021 24 Citations

SARS-CoV-2 receptor binding domain-specific antibodies activate platelets with features resembling the pathogenic antibodies in heparin-induced thrombocytopenia. (Zhu W, Zheng Y, Yu M, Wei J, Zhang Y, Topchyan P, Nguyen C, Janecke R, Kreuziger LB, White GC, Hari P, Aster R, Cui W, Jobe S, Graham MB, Wang D, Wen R) Res Sq 2021 Apr 26 PMID: 34013243 PMCID: PMC8132233 05/21/2021

Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. (Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J) Blood 2021 Jun 10;137(23):3259-3271 PMID: 33512434 PMCID: PMC8351901 SCOPUS ID: 2-s2.0-85107817855 01/30/2021 11 Citations

Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis. (Bluemn T, Schmitz J, Chen Y, Zheng Y, Zhang Y, Zheng S, Burns R, DeJong J, Christiansen L, Izaguirre-Carbonell J, Wang D, Zhu N) Exp Hematol 2021 Feb;94:37-46 PMID: 33346030 PMCID: PMC10041880 SCOPUS ID: 2-s2.0-85098572050 12/22/2020 16 Citations

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. (Li J, Zhang L, Zheng Y, Shao R, Liang Q, Yu W, Wang H, Zou W, Wang D, Xiang J, Lin A) Elife 2020 Dec 03;9 PMID: 33270017 PMCID: PMC7714394 SCOPUS ID: 2-s2.0-85097125352 12/04/2020 16 Citations

Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity. (Luo L, Chen Y, Chen X, Zheng Y, Zhou V, Yu M, Burns R, Zhu W, Fu G, Felix JC, Hartley C, Damnernsawad A, Zhang J, Wen R, Drobyski WR, Gao C, Wang D) J Immunol 2020 Dec 15;205(12):3480-3490 PMID: 33158956 PMCID: PMC7955895 SCOPUS ID: 2-s2.0-85097490484 11/08/2020 6 Citations

Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. (Gupta S, Konradt C, Corken A, Ware J, Nieswandt B, Di Paola J, Yu M, Wang D, Nieman MT, Whiteheart SW, Brass LF) Proc Natl Acad Sci U S A 2020 Sep 29;117(39):24316-24325 PMID: 32929010 PMCID: PMC7533880 SCOPUS ID: 2-s2.0-85092289547 09/16/2020 53 Citations

Expression of NrasQ61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice. (Wen Z, Rajagopalan A, Flietner ED, Yun G, Chesi M, Furumo Q, Burns RT, Papadas A, Ranheim EA, Pagenkopf AC, Morrow ZT, Finn R, Zhou Y, Li S, You X, Jensen J, Yu M, Cicala A, Menting J, Mitsiades CS, Callander NS, Bergsagel PL, Wang D, Asimakopoulos F, Zhang J) Blood 2021 Jan 07;137(1):61-74 PMID: 32640012 PMCID: PMC7808014 SCOPUS ID: 2-s2.0-85099107626 07/09/2020 24 Citations

Transcriptional Regulation of Natural Killer Cell Development and Functions. (Wang D, Malarkannan S) Cancers (Basel) 2020 Jun 16;12(6) PMID: 32560225 PMCID: PMC7352776 SCOPUS ID: 2-s2.0-85088411457 06/21/2020 48 Citations

Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. (Yang C, Siebert JR, Burns R, Zheng Y, Mei A, Bonacci B, Wang D, Urrutia RA, Riese MJ, Rao S, Carlson KS, Thakar MS, Malarkannan S) Elife 2020 May 14;9 PMID: 32406817 PMCID: PMC7255804 SCOPUS ID: 2-s2.0-85085630468 05/15/2020 22 Citations

CXCR5⁺PD-1⁺ follicular helper CD8 T cells control B cell tolerance. (Chen Y, Yu M, Zheng Y, Fu G, Xin G, Zhu W, Luo L, Burns R, Li QZ, Dent AL, Zhu N, Cui W, Malherbe L, Wen R, Wang D) Nat Commun 2019 Sep 27;10(1):4415 PMID: 31562329 PMCID: PMC6765049 SCOPUS ID: 2-s2.0-85072692451 09/29/2019 71 Citations

Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells. (Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S) Cancer Immunol Res 2019 Oct;7(10):1647-1662 PMID: 31515257 PMCID: PMC7428857 SCOPUS ID: 2-s2.0-85072848720 09/14/2019 11 Citations

Regulatory T Cells Control PF4/Heparin Antibody Production in Mice. (Zheng Y, Zhu W, Haribhai D, Williams CB, Aster RH, Wen R, Wang D) J Immunol 2019 Oct 01;203(7):1786-1792 PMID: 31471526 PMCID: PMC6944762 SCOPUS ID: 2-s2.0-85072761081 09/01/2019 13 Citations

Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression. (Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta HM, Miller HE, Olson M, Rajasekaran K, Ernstoff MS, Wang D, Malarkannan S, Wang L) Cancer Immunol Res 2019 Sep;7(9):1497-1510 PMID: 31340983 PMCID: PMC6726548 SCOPUS ID: 2-s2.0-85071783703 07/26/2019 141 Citations

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. (Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK, Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O) Cancer Discov 2019 Oct;9(10):1452-1467 PMID: 31285298 PMCID: PMC6774834 SCOPUS ID: 2-s2.0-85071298982 07/10/2019 77 Citations

Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia. (Izaguirre-Carbonell J, Christiansen L, Burns R, Schmitz J, Li C, Mokry RL, Bluemn T, Zheng Y, Shen J, Carlson KS, Rao S, Wang D, Zhu N) Blood Adv 2019 May 14;3(9):1499-1511 PMID: 31076406 PMCID: PMC6517669 SCOPUS ID: 2-s2.0-85068626845 05/12/2019 24 Citations

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8⁺ T-Cell Activation. (Wang Z, Vaughan TY, Zhu W, Chen Y, Fu G, Medrzycki M, Nishio H, Bunting ST, Hankey-Giblin PA, Nusrat A, Parkos CA, Wang D, Wen R, Bunting KD) Front Immunol 2019;10:486 PMID: 30936879 PMCID: PMC6431666 SCOPUS ID: 2-s2.0-85064229962 04/03/2019 14 Citations

PTPRJ: a novel inherited thrombocytopenia gene. (Wen R, Wang D) Blood 2019 Mar 21;133(12):1272-1274 PMID: 30898775 PMCID: PMC6428668 SCOPUS ID: 2-s2.0-85063642493 03/23/2019 2 Citations

Mature IgD^low/- B cells maintain tolerance by promoting regulatory T cell homeostasis. (Ray A, Khalil MI, Pulakanti KL, Burns RT, Gurski CJ, Basu S, Wang D, Rao S, Dittel BN) Nat Commun 2019 Jan 14;10(1):190 PMID: 30643147 PMCID: PMC6331566 SCOPUS ID: 2-s2.0-85060004031 01/16/2019 30 Citations

MiR-192-5p in the Kidney Protects Against the Development of Hypertension. (Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M) Hypertension 2019 Feb;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019 54 Citations

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. (Zhang M, Dong Y, Hu F, Yang D, Zhao Q, Lv C, Wang Y, Xia C, Weng Q, Liu X, Li C, Zhou P, Wang T, Guan Y, Guo R, Liu L, Geng Y, Wu H, Du J, Hu Z, Xu S, Chen J, He A, Liu B, Wang D, Yang YG, Wang J) Nat Immunol 2018 Sep;19(9):1036 PMID: 29915300 SCOPUS ID: 2-s2.0-85048663838 06/20/2018 2 Citations

Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. (Zhang M, Dong Y, Hu F, Yang D, Zhao Q, Lv C, Wang Y, Xia C, Weng Q, Liu X, Li C, Zhou P, Wang T, Guan Y, Guo R, Liu L, Geng Y, Wu H, Du J, Hu Z, Xu S, Chen J, He A, Liu B, Wang D, Yang YG, Wang J) Nat Immunol 2018 Mar;19(3):279-290 PMID: 29434353 PMCID: PMC6190911 SCOPUS ID: 2-s2.0-85041891411 02/13/2018 39 Citations

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis. (Zeng H, Yu M, Tan H, Li Y, Su W, Shi H, Dhungana Y, Guy C, Neale G, Cloer C, Peng J, Wang D, Chi H) Sci Adv 2018 Jan;4(1):eaar5701 PMID: 29399633 PMCID: PMC5792226 SCOPUS ID: 2-s2.0-85042155531 02/06/2018 37 Citations

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. (Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D) Nat Commun 2017 Nov 13;8(1):1457 PMID: 29133930 PMCID: PMC5684131 SCOPUS ID: 2-s2.0-85034212045 11/15/2017 39 Citations

IVIg for Treatment of Severe Refractory Heparin-Induced Thrombocytopenia. (Padmanabhan A, Jones CG, Pechauer SM, Curtis BR, Bougie DW, Irani MS, Bryant BJ, Alperin JB, Deloughery TG, Mulvey KP, Dhakal B, Wen R, Wang D, Aster RH) Chest 2017 Sep;152(3):478-485 PMID: 28427966 PMCID: PMC5812774 SCOPUS ID: 2-s2.0-85028972116 04/22/2017 105 Citations

Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development. (Fu G, Yu M, Chen Y, Zheng Y, Zhu W, Newman DK, Wang D, Wen R) Eur J Immunol 2017 Jan;47(1):74-83 PMID: 27759161 PMCID: PMC5559087 SCOPUS ID: 2-s2.0-84999652051 10/21/2016 8 Citations

The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part. (Chang YI, Damnernsawad A, Kong G, You X, Wang D, Zhang J) Small GTPases 2017 Oct 02;8(4):233-236 PMID: 27449543 PMCID: PMC5680677 SCOPUS ID: 2-s2.0-84981205611 07/28/2016 4 Citations

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis. (Padmanabhan A, Jones CG, Curtis BR, Bougie DW, Sullivan MJ, Peswani N, McFarland JG, Eastwood D, Wang D, Aster RH) Chest 2016 Sep;150(3):506-15 PMID: 26905366 PMCID: PMC5028397 SCOPUS ID: 2-s2.0-84995622136 02/26/2016 86 Citations

Kras Is Critical for B Cell Lymphopoiesis. (Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, Zhou F, Zhu W, Wu Z, Zhang J, Wen R, Wang D) J Immunol 2016 Feb 15;196(4):1678-85 PMID: 26773157 PMCID: PMC4744498 SCOPUS ID: 2-s2.0-84958580592 01/17/2016 23 Citations

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms (Yu C, Yang Q, Chen Y, Wang D, Levine R, Crispino J, Wen Q, Huang Z) Cell and Bioscience 2016;6(1) SCOPUS ID: 2-s2.0-85007279960 01/01/2016 2 Citations

Evaluation of nestin or osterix promoter-driven cre/loxp system in studying the biological functions of murine osteoblastic cells (Su X, Yu M, Qiu G, Zheng Y, Chen Y, Wen R, Fu G, Zhu W, Chen J, Wu N, Ma P, Chen W, Wu Z, Wang D) American Journal of Translational Research 2016;8(3):1447-1459 SCOPUS ID: 2-s2.0-84964550193 01/01/2016 4 Citations

R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding. (Yan X, Yan M, Guo Y, Singh G, Chen Y, Yu M, Wang D, Hillery CA, Chan AM) PLoS One 2015;10(12):e0145218 PMID: 26710069 PMCID: PMC4692399 SCOPUS ID: 2-s2.0-84957536563 12/29/2015 9 Citations

A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. (Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W) Cell Rep 2015 Nov 10;13(6):1118-1124 PMID: 26527008 PMCID: PMC4859432 SCOPUS ID: 2-s2.0-84946826734 11/04/2015 116 Citations

Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic Stem Cells. (Laiosa MD, Tate ER, Ahrenhoerster LS, Chen Y, Wang D) Environ Health Perspect 2016 Jul;124(7):957-65 PMID: 26495820 PMCID: PMC4937855 SCOPUS ID: 2-s2.0-84977111532 10/27/2015 23 Citations

A modified PF4-dependent, CD62p expression assay selectively detects serotonin-releasing antibodies in patients suspected of HIT. (Padmanabhan A, Jones CG, Bougie DW, Curtis BR, McFarland JG, Wang D, Aster RH) Thromb Haemost 2015 Nov 25;114(6):1322-3 PMID: 26177881 PMCID: PMC4849413 SCOPUS ID: 2-s2.0-84983168956 07/17/2015 26 Citations

Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. (Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK) PLoS One 2015;10(3):e0119739 PMID: 25793864 PMCID: PMC4368822 SCOPUS ID: 2-s2.0-84925859948 03/21/2015 14 Citations

Critical role of CD4 T cells in PF4/heparin antibody production in mice. (Zheng Y, Yu M, Padmanabhan A, Aster RH, Yuan L, Wen R, Wang D) Blood 2015 Mar 12;125(11):1826-9 PMID: 25595736 PMCID: PMC4357587 SCOPUS ID: 2-s2.0-84941938986 01/18/2015 24 Citations

Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis. (Padmanabhan A, Jones CG, Bougie DW, Curtis BR, McFarland JG, Wang D, Aster RH) Blood 2015 Jan 01;125(1):155-61 PMID: 25342714 PMCID: PMC4281824 SCOPUS ID: 2-s2.0-84920555104 10/25/2014 76 Citations

B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. (Zheng Y, Wang AW, Yu M, Padmanabhan A, Tourdot BE, Newman DK, White GC, Aster RH, Wen R, Wang D) Blood 2014 Feb 06;123(6):931-4 PMID: 24357731 PMCID: PMC3916881 SCOPUS ID: 2-s2.0-84897574667 12/21/2013 46 Citations

Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates. (Qi X, Hong J, Chaves L, Zhuang Y, Chen Y, Wang D, Chabon J, Graham B, Ohmori K, Li Y, Huang H) Immunity 2013 Jul 25;39(1):97-110 PMID: 23871207 PMCID: PMC3755602 SCOPUS ID: 2-s2.0-84880728627 07/23/2013 124 Citations

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. (Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C) Nat Immunol 2013 Jul;14(7):732-40 PMID: 23727894 PMCID: PMC4084713 SCOPUS ID: 2-s2.0-84879355943 06/04/2013 118 Citations

Critical role for mouse marginal zone B cells in PF4/heparin antibody production. (Zheng Y, Yu M, Podd A, Yuan L, Newman DK, Wen R, Arepally G, Wang D) Blood 2013 Apr 25;121(17):3484-92 PMID: 23460609 PMCID: PMC3637017 SCOPUS ID: 2-s2.0-84879407772 03/06/2013 48 Citations

Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells. (Yu M, Chen Y, He Y, Podd A, Fu G, Wright JA, Kleiman E, Khan WN, Wen R, Wang D) J Immunol 2012 Dec 01;189(11):5185-93 PMID: 23087406 PMCID: PMC3786778 SCOPUS ID: 2-s2.0-84869825522 10/23/2012 18 Citations

Tyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cells. (Malherbe LP, Wang D) Sci Signal 2012 Jul 31;5(235):pe33 PMID: 22855504 PMCID: PMC4307919 SCOPUS ID: 2-s2.0-84864554527 08/03/2012 4 Citations

Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection. (Fu G, Chen Y, Schuman J, Wang D, Wen R) J Immunol 2012 Sep 01;189(5):2326-32 PMID: 22837484 PMCID: PMC3528184 SCOPUS ID: 2-s2.0-84865414173 07/28/2012 21 Citations

SU-E-J-11: Characterization of Interfractioanal Anatomical Variations in Post-Operative Radiation Therapy for Prostate Bed. (Liu F, Ahunbay E, Christian R, Lawton C, Wang D, Li X) Med Phys 2012 Jun;39(6Part6):3654 PMID: 28517560 SCOPUS ID: 2-s2.0-85024816223 06/01/2012

STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. (Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D) J Biol Chem 2012 Mar 30;287(14):11234-9 PMID: 22318729 PMCID: PMC3322890 SCOPUS ID: 2-s2.0-84859487740 02/10/2012 205 Citations

Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. (Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin X) J Biol Chem 2011 Dec 23;286(51):43651-43659 PMID: 22041900 PMCID: PMC3243564 SCOPUS ID: 2-s2.0-83755168978 11/02/2011 52 Citations

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. (Chen Y, Yu M, Dai X, Zogg M, Wen R, Weiler H, Wang D) J Exp Med 2011 May 09;208(5):923-35 PMID: 21502331 PMCID: PMC3092340 SCOPUS ID: 2-s2.0-79956105663 04/20/2011 34 Citations

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation (Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang TT, Wen R, Hoffmann A, Wang D, Miyamoto S) Immunity 25 March 2011;34(3):449 SCOPUS ID: 2-s2.0-79952746010 03/25/2011 9 Citations

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation. (Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang TT, Wen R, Hoffmann A, Wang D, Miyamoto S) Immunity 2011 Feb 25;34(2):188-200 PMID: 21333553 PMCID: PMC3111750 SCOPUS ID: 2-s2.0-79951768852 02/22/2011 33 Citations

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. (Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, Zarbock A) Blood 2010 Apr 15;115(15):3118-27 PMID: 20167705 PMCID: PMC2858472 SCOPUS ID: 2-s2.0-77951027428 02/20/2010 148 Citations

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. (Fu G, Chen Y, Yu M, Podd A, Schuman J, He Y, Di L, Yassai M, Haribhai D, North PE, Gorski J, Williams CB, Wang D, Wen R) J Exp Med 2010 Feb 15;207(2):309-18 PMID: 20123962 PMCID: PMC2822604 SCOPUS ID: 2-s2.0-77149154686 02/04/2010 116 Citations

The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. (Jana S, Jailwala P, Haribhai D, Waukau J, Glisic S, Grossman W, Mishra M, Wen R, Wang D, Williams CB, Ghosh S) Eur J Immunol 2009 Sep;39(9):2571-83 PMID: 19701891 SCOPUS ID: 2-s2.0-70349243737 08/25/2009 45 Citations

IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. (Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H) J Immunol 2009 Mar 01;182(5):2835-41 PMID: 19234178 PMCID: PMC2756103 SCOPUS ID: 2-s2.0-64849086165 02/24/2009 112 Citations

A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. (Schuman J, Chen Y, Podd A, Yu M, Liu HH, Wen R, Chen ZJ, Wang D) Blood 2009 May 07;113(19):4566-74 PMID: 19196865 PMCID: PMC2680363 SCOPUS ID: 2-s2.0-66549125216 02/07/2009 71 Citations

Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. (Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H) Blood 2008 Dec 15;112(13):4905-14 PMID: 18796632 PMCID: PMC2597598 SCOPUS ID: 2-s2.0-58149376483 09/18/2008 55 Citations

Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. (Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michalek S, He Y, Yu M, Fu YX, Wen R, Wu H, Wang D) J Biol Chem 2008 Oct 24;283(43):29593-601 PMID: 18728019 PMCID: PMC2570883 SCOPUS ID: 2-s2.0-57649174473 08/30/2008 28 Citations

T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: an implication of differential NF-kappaB dependence of naïve and memory T cells during T cell receptor-mediated responses. (Zeng H, Chen Y, Yu M, Xue L, Gao X, Morris SW, Wang D, Wen R) J Biol Chem 2008 Sep 05;283(36):24392-9 PMID: 18583339 PMCID: PMC2528987 SCOPUS ID: 2-s2.0-54049097968 06/28/2008 15 Citations

Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells. (Awasthi A, Samarakoon A, Dai X, Wen R, Wang D, Malarkannan S) Genes Immun 2008 Sep;9(6):522-35 PMID: 18548087 PMCID: PMC4623703 SCOPUS ID: 2-s2.0-51249121801 06/13/2008 30 Citations

A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. (Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, Wang D) Blood 2008 May 01;111(9):4627-36 PMID: 18319399 PMCID: PMC2343596 SCOPUS ID: 2-s2.0-47149093727 03/06/2008 40 Citations

STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output. (Li G, Wang Z, Zhang Y, Kang Z, Haviernikova E, Cui Y, Hennighausen L, Moriggl R, Wang D, Tse W, Bunting KD) Exp Hematol 2007 Nov;35(11):1684-94 PMID: 17976521 PMCID: PMC2134320 SCOPUS ID: 2-s2.0-35448975099 11/03/2007 35 Citations

Bruton's tyrosine kinase mediates NF-κB activation and B cell survival by B cell-activating factor receptor of the TNF-R family (Shinners NP, Carlesso G, Castro I, Hoek KL, Corn RA, Woodland RT, Scott ML, Wang D, Khan WN) Journal of Immunology 1 November 2007;179(9):6369 SCOPUS ID: 2-s2.0-59849091473 11/01/2007 18 Citations

Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation. (Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D) J Immunol 2007 Sep 15;179(6):3752-62 PMID: 17785812 SCOPUS ID: 2-s2.0-35748981185 09/06/2007 38 Citations

Bruton's tyrosine kinase mediates NF-kappa B activation and B cell survival by B cell-activating factor receptor of the TNF-R family. (Shinners NP, Carlesso G, Castro I, Hoek KL, Corn RA, Woodland RT, Scott ML, Wang D, Khan WN) J Immunol 2007 Sep 15;179(6):3872-80 PMID: 17785824 SCOPUS ID: 2-s2.0-35748966698 09/06/2007 89 Citations

Stat5 is essential for early B cell development but not for B cell maturation and function. (Dai X, Chen Y, Di L, Podd A, Li G, Bunting KD, Hennighausen L, Wen R, Wang D) J Immunol 2007 Jul 15;179(2):1068-79 PMID: 17617599 SCOPUS ID: 2-s2.0-34548807675 07/10/2007 53 Citations

Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. (Bai L, Chen Y, He Y, Dai X, Lin X, Wen R, Wang D) Mol Cell Biol 2007 Sep;27(17):5957-67 PMID: 17591700 PMCID: PMC1952164 SCOPUS ID: 2-s2.0-34548203816 06/27/2007 19 Citations

Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. (Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M, Budd RC) J Biol Chem 2007 Jul 06;282(27):19365-74 PMID: 17462996 PMCID: PMC4521413 SCOPUS ID: 2-s2.0-34547111577 04/28/2007 64 Citations

Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo. (Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM) J Immunol 2007 May 01;178(9):5496-504 PMID: 17442931 PMCID: PMC2664650 SCOPUS ID: 2-s2.0-34247557502 04/20/2007 53 Citations

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. (Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C) J Biol Chem 2007 Mar 30;282(13):9358-9363 PMID: 17277312 SCOPUS ID: 2-s2.0-34247593586 02/06/2007 1292 Citations

The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (Blonska M, Pappu BP, Matsumoto R, Li H, Su B, Wang D, Lin X) Immunity 2007 Jan;26(1):55-66 PMID: 17189706 PMCID: PMC1802095 SCOPUS ID: 2-s2.0-33846235557 12/27/2006 88 Citations

B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells. (Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang D) J Immunol 2007 Jan 01;178(1):49-57 PMID: 17182539 SCOPUS ID: 2-s2.0-33845917204 12/22/2006 22 Citations

Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. (Wen R, Chen Y, Bai L, Fu G, Schuman J, Dai X, Zeng H, Yang C, Stephan RP, Cleveland JL, Wang D) Mol Cell Biol 2006 Dec;26(24):9364-76 PMID: 17030619 PMCID: PMC1698523 SCOPUS ID: 2-s2.0-33845383712 10/13/2006 30 Citations

Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. (Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D, Malarkannan S) J Immunol 2006 Oct 15;177(8):5365-76 PMID: 17015722 SCOPUS ID: 2-s2.0-33749524546 10/04/2006 43 Citations

Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. (Hoek KL, Antony P, Lowe J, Shinners N, Sarmah B, Wente SR, Wang D, Gerstein RM, Khan WN) J Immunol 2006 Oct 15;177(8):5405-13 PMID: 17015726 SCOPUS ID: 2-s2.0-33749535412 10/04/2006 36 Citations

Proteasome-dependent down-regulation of activated Stat5A in the nucleus. (Chen Y, Dai X, Haas AL, Wen R, Wang D) Blood 2006 Jul 15;108(2):566-74 PMID: 16569768 PMCID: PMC1895487 SCOPUS ID: 2-s2.0-33745937881 03/30/2006 26 Citations

Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. (Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, Brindle PK) Blood 2006 Jun 01;107(11):4407-16 PMID: 16424387 PMCID: PMC1895794 SCOPUS ID: 2-s2.0-33744495991 01/21/2006 52 Citations

Erratum: Signaling by the cytokine receptor superfamily (Annals of the New York Academy of Sciences (1998) 865 (1-9) DOI: 10.1111/j.1749-6632.1998.tb11157. x) (Ihle JN, Thierfelder W, Teglund S, Stravopodis D, Wang D, Feng J, Parganas E) Annals of the New York Academy of Sciences October 2006;1078:627 SCOPUS ID: 2-s2.0-33845714715 01/01/2006

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. (Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X) Immunity 2005 Dec;23(6):575-85 PMID: 16356856 SCOPUS ID: 2-s2.0-28844499919 12/17/2005 246 Citations

Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. (Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R, Wang D) Mol Cell Biol 2006 Jan;26(1):88-99 PMID: 16354682 PMCID: PMC1317611 SCOPUS ID: 2-s2.0-33645237961 12/16/2005 12 Citations

Negative regulation of lymphocyte activation by the adaptor protein LAX. (Zhu M, Granillo O, Wen R, Yang K, Dai X, Wang D, Zhang W) J Immunol 2005 May 01;174(9):5612-9 PMID: 15843560 SCOPUS ID: 2-s2.0-17844394466 04/22/2005 46 Citations

Stat5 tetramer formation is associated with leukemogenesis. (Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, Bunting KD, Wagner EF, Sonneck K, Valent P, Ihle JN, Beug H) Cancer Cell 2005 Jan;7(1):87-99 PMID: 15652752 SCOPUS ID: 2-s2.0-19944431828 01/18/2005 201 Citations

An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. (Wen R, Chen Y, Schuman J, Fu G, Yang S, Zhang W, Newman DK, Wang D) EMBO J 2004 Oct 13;23(20):4007-17 PMID: 15372077 PMCID: PMC524341 SCOPUS ID: 2-s2.0-8144221736 09/17/2004 34 Citations

NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. (Regunathan J, Chen Y, Wang D, Malarkannan S) Blood 2005 Jan 01;105(1):233-40 PMID: 15328154 PMCID: PMC3889208 SCOPUS ID: 2-s2.0-11144236862 08/26/2004 54 Citations

Phospholipase Cgamma2 contributes to stable thrombus formation on VWF. (Rathore V, Wang D, Newman DK, Newman PJ) FEBS Lett 2004 Aug 27;573(1-3):26-30 PMID: 15327970 SCOPUS ID: 2-s2.0-4344564590 08/26/2004 14 Citations

Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism. (Zhu Y, Chen L, Huang Z, Alkan S, Bunting KD, Wen R, Wang D, Huang H) J Immunol 2004 Sep 01;173(5):2918-22 PMID: 15322148 SCOPUS ID: 2-s2.0-4344641107 08/24/2004 38 Citations

The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling (Lin X, Wang D) Seminars in Immunology December 2004;16(6):429-435 SCOPUS ID: 2-s2.0-8444225946 01/01/2004 101 Citations

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. (Wen R, Chen Y, Xue L, Schuman J, Yang S, Morris SW, Wang D) J Biol Chem 2003 Oct 31;278(44):43654-62 PMID: 12928432 SCOPUS ID: 2-s2.0-0242321892 08/21/2003 39 Citations

Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. (Xue L, Morris SW, Orihuela C, Tuomanen E, Cui X, Wen R, Wang D) Nat Immunol 2003 Sep;4(9):857-65 PMID: 12910267 SCOPUS ID: 2-s2.0-0041381357 08/12/2003 164 Citations

Identification of Shp-2 as a Stat5A phosphatase. (Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS, Wang D) J Biol Chem 2003 May 09;278(19):16520-7 PMID: 12615921 SCOPUS ID: 2-s2.0-0037593839 03/05/2003 102 Citations

Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R. (Wen R, Jou ST, Chen Y, Hoffmeyer A, Wang D) J Immunol 2002 Dec 15;169(12):6743-52 PMID: 12471105 SCOPUS ID: 2-s2.0-0037114147 12/10/2002 68 Citations

The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. (Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, Gartner TK) Blood 2003 Apr 01;101(7):2646-51 PMID: 12446460 SCOPUS ID: 2-s2.0-0037512367 11/26/2002 77 Citations

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. (Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Carpino N, Wang D, Ihle JN) Mol Cell Biol 2002 Dec;22(24):8580-91 PMID: 12446777 PMCID: PMC139888 SCOPUS ID: 2-s2.0-0037695593 11/26/2002 334 Citations

Variations in the human phospholipase Cgamma2 gene in patients with B-cell defects of unknown etiology. (Wang D, Boylin EC, Minegishi Y, Wen R, Smith CI, Ihle JN, Conley ME) Immunogenetics 2001 Sep;53(7):550-6 PMID: 11685467 SCOPUS ID: 2-s2.0-0034764039 10/31/2001 7 Citations

Differential roles of cytokine signaling during T-cell development. (Moriggl R, Marine JC, Topham DJ, Teglund S, Sexl V, McKay C, Piekorz R, Wang D, Parganas E, Yoshimura A, Ihle JN) Cold Spring Harb Symp Quant Biol 1999;64:389-95 PMID: 11232312 SCOPUS ID: 2-s2.0-0033510145 03/10/2001 2 Citations

Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. (Wen R, Wang D, McKay C, Bunting KD, Marine JC, Vanin EF, Zambetti GP, Korsmeyer SJ, Ihle JN, Cleveland JL) Mol Cell Biol 2001 Jan;21(2):678-89 PMID: 11134353 PMCID: PMC86650 SCOPUS ID: 2-s2.0-0035159241 01/03/2001 64 Citations

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. (Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, Lee CK, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, Loh ML, Levy DE, Ihle JN, Gilliland DG) Mol Cell 2000 Sep;6(3):693-704 PMID: 11030348 SCOPUS ID: 2-s2.0-0033639119 10/13/2000 278 Citations

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. (Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN) Immunity 2000 Jul;13(1):25-35 PMID: 10933392 SCOPUS ID: 2-s2.0-0033624638 08/10/2000 431 Citations

A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. (Wang D, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, Ihle JN) EMBO J 2000 Feb 01;19(3):392-9 PMID: 10654938 PMCID: PMC305576 SCOPUS ID: 2-s2.0-0034142208 02/02/2000 107 Citations

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. (Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN) Cell 1999 Sep 03;98(5):609-16 PMID: 10490100 SCOPUS ID: 2-s2.0-0033520467 09/18/1999 470 Citations

SOCS3 is essential in the regulation of fetal liver erythropoiesis. (Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN) Cell 1999 Sep 03;98(5):617-27 PMID: 10490101 SCOPUS ID: 2-s2.0-0033520389 09/18/1999 319 Citations

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. (Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN) Immunity 1999 Feb;10(2):249-59 PMID: 10072077 SCOPUS ID: 2-s2.0-0033082138 03/11/1999 496 Citations

Expression of c-Myc in response to colony-stimulating factor-1 requires mitogen-activated protein kinase kinase-1. (Cheng M, Wang D, Roussel MF) J Biol Chem 1999 Mar 05;274(10):6553-8 PMID: 10037749 SCOPUS ID: 2-s2.0-0033525882 02/26/1999 51 Citations

Signaling by the cytokine receptor superfamily. (Ihle JN, Thierfelder W, Teglund S, Stravopodis D, Wang D, Feng J, Parganas E) Ann N Y Acad Sci 1998 Dec 11;865:1-9 PMID: 9927991 SCOPUS ID: 2-s2.0-0032417376 02/03/1999 98 Citations

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. (Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN) Cell 1998 May 29;93(5):841-50 PMID: 9630227 SCOPUS ID: 2-s2.0-0000943469 06/18/1998 1112 Citations

The roles of Jaks and Stats in cytokine signaling. (Ihle JN, Stravapodis D, Parganas E, Thierfelder W, Feng J, Wang D, Teglund S) Cancer J Sci Am 1998 May;4 Suppl 1:S84-91 PMID: 9619276 SCOPUS ID: 2-s2.0-0031844302 06/10/1998 23 Citations

Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. (Quelle FW, Wang J, Feng J, Wang D, Cleveland JL, Ihle JN, Zambetti GP) Genes Dev 1998 Apr 15;12(8):1099-107 PMID: 9553040 PMCID: PMC316716 SCOPUS ID: 2-s2.0-0032522453 05/30/1998 94 Citations

Jak2 is essential for signaling through a variety of cytokine receptors. (Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN) Cell 1998 May 01;93(3):385-95 PMID: 9590173 SCOPUS ID: 2-s2.0-0032076542 05/20/1998 954 Citations

Naturally occurring dominant negative variants of Stat5. (Wang D, Stravopodis D, Teglund S, Kitazawa J, Ihle JN) Mol Cell Biol 1996 Nov;16(11):6141-8 PMID: 8887644 PMCID: PMC231617 SCOPUS ID: 2-s2.0-0029826282 11/01/1996 227 Citations

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. (Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN) Mol Cell Biol 1996 Apr;16(4):1622-31 PMID: 8657137 PMCID: PMC231148 SCOPUS ID: 2-s2.0-0029866781 04/01/1996 243 Citations

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Demin Wang PhD

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