Faculty Collaboration Database

Edward J. Zuperku PhD, MS

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology

Publications (112)

Pulmonary stretch receptor modulation of synaptic inhibition shapes the discharge pattern of respiratory premotor neurons. (Zuperku EJ, Hopp FA, Stucke AG) Respir Physiol Neurobiol 2025;336:104420 PMID: 40147693 SCOPUS ID: 2-s2.0-105001504877 03/28/2025

Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs. (Palkovic B, Mustapic S, Saric I, Stuth EAE, Stucke AG, Zuperku EJ) Front Physiol 2023;14:1156076 PMID: 37362432 PMCID: PMC10285059 SCOPUS ID: 2-s2.0-85162654247 06/26/2023 1 Citation

Contribution of the caudal medullary raphe to opioid induced respiratory depression. (Palkovic B, Cook-Snyder D, Callison JJ, Langer TM 3rd, Nugent R, Stuth EAE, Zuperku EJ, Stucke AG) Respir Physiol Neurobiol 2022 May;299:103855 PMID: 35124284 PMCID: PMC8897277 SCOPUS ID: 2-s2.0-85124754852 02/07/2022 19 Citations

Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex. (Palkovic B, Callison JJ, Marchenko V, Stuth EAE, Zuperku EJ, Stucke AG) Anesthesiology 2021 Oct 01;135(4):649-672 PMID: 34352068 PMCID: PMC8489159 SCOPUS ID: 2-s2.0-85115636053 08/06/2021 24 Citations

Interaction between the pulmonary stretch receptor and pontine control of expiratory duration. (Zuperku EJ, Hopp FA, Stuth EAE, Stucke AG) Respir Physiol Neurobiol 2021 Nov;293:103715 PMID: 34126261 PMCID: PMC8418273 SCOPUS ID: 2-s2.0-85108097773 06/15/2021 5 Citations

Reflexes from the Lungs and Chest Wall (McCrimmon DR, Alheid GF, Zuperku EJ) Encyclopedia of Respiratory Medicine Second Edition 1 January 2021;2:261-268 SCOPUS ID: 2-s2.0-85143095758 01/01/2021

Multi-Level Regulation of Opioid-Induced Respiratory Depression. (Palkovic B, Marchenko V, Zuperku EJ, Stuth EAE, Stucke AG) Physiology (Bethesda) 2020 Nov 01;35(6):391-404 PMID: 33052772 PMCID: PMC7864237 SCOPUS ID: 2-s2.0-85092886511 10/15/2020 67 Citations

Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate. (Navarrete-Opazo AA, Cook-Snyder DR, Miller JR, Callison JJ, McCarthy N, Palkovic B, Stuth EAE, Zuperku EJ, Stucke AG) Respir Physiol Neurobiol 2020 Jun;277:103401 PMID: 32036030 PMCID: PMC7309965 SCOPUS ID: 2-s2.0-85083237275 02/10/2020 31 Citations

The contribution of endogenous glutamatergic input in the ventral respiratory column to respiratory rhythm. (Cook-Snyder DR, Miller JR, Navarrete-Opazo AA, Callison JJ, Peterson RC, Hopp FA, Stuth EAE, Zuperku EJ, Stucke AG) Respir Physiol Neurobiol 2019 Feb;260:37-52 PMID: 30502519 PMCID: PMC6397772 SCOPUS ID: 2-s2.0-85058568248 12/07/2018 18 Citations

Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency. (Zuperku EJ, Stucke AG, Krolikowski JG, Tomlinson J, Hopp FA, Stuth EA) Respir Physiol Neurobiol 2019 Jul;265:127-140 PMID: 29964165 PMCID: PMC6310670 SCOPUS ID: 2-s2.0-85049327239 07/03/2018 26 Citations

A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits. (Miller JR, Zuperku EJ, Stuth EAE, Banerjee A, Hopp FA, Stucke AG) Anesthesiology 2017 Sep;127(3):502-514 PMID: 28590302 PMCID: PMC5561451 SCOPUS ID: 2-s2.0-85020254103 06/08/2017 44 Citations

Characteristics of breathing rate control mediated by a subregion within the pontine parabrachial complex. (Zuperku EJ, Stucke AG, Hopp FA, Stuth EA) J Neurophysiol 2017 Mar 01;117(3):1030-1042 PMID: 27974449 PMCID: PMC5338614 SCOPUS ID: 2-s2.0-85014611292 12/16/2016 33 Citations

Activation of 5-HT1A receptors in the preBötzinger region has little impact on the respiratory pattern. (Radocaj T, Mustapic S, Prkic I, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ) Respir Physiol Neurobiol 2015 Jul;212-214:9-19 PMID: 25850079 SCOPUS ID: 2-s2.0-84928340110 04/08/2015 14 Citations

Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo. (Stucke AG, Miller JR, Prkic I, Zuperku EJ, Hopp FA, Stuth EA) Anesthesiology 2015 Jun;122(6):1288-98 PMID: 25751234 PMCID: PMC4639929 SCOPUS ID: 2-s2.0-84937512318 03/10/2015 46 Citations

Automatic classification of canine PRG neuronal discharge patterns using K-means clustering. (Zuperku EJ, Prkic I, Stucke AG, Miller JR, Hopp FA, Stuth EA) Respir Physiol Neurobiol 2015 Feb 01;207:28-39 PMID: 25511381 PMCID: PMC4638195 SCOPUS ID: 2-s2.0-84920141232 12/17/2014 10 Citations

Rebuttal from Peter M. Lalley, Paul M. Pilowsky, Hubert V. Forster and Edward J. Zuperku. (Lalley PM, Pilowsky PM, Forster HV, Zuperku EJ) J Physiol 2014 Mar 15;592(6):1169 PMID: 24634014 PMCID: PMC3961074 SCOPUS ID: 2-s2.0-84896041719 03/19/2014 3 Citations

CrossTalk opposing view: The pre-Botzinger complex is not essential for respiratory depression following systemic administration of opioid analgesics. (Lalley PM, Pilowsky PM, Forster HV, Zuperku EJ) J Physiol 2014 Mar 15;592(6):1163-6 PMID: 24634012 PMCID: PMC3961072 SCOPUS ID: 2-s2.0-84896040360 03/19/2014 39 Citations

Effects of anesthetics, sedatives, and opioids on ventilatory control. (Stuth EA, Stucke AG, Zuperku EJ) Compr Physiol 2012 Oct;2(4):2281-367 PMID: 23720250 SCOPUS ID: 2-s2.0-84891708026 05/31/2013 29 Citations

Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs. (Prkic I, Mustapic S, Radocaj T, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ) J Neurophysiol 2012 Nov;108(9):2430-41 PMID: 22875901 PMCID: PMC3545180 SCOPUS ID: 2-s2.0-84868322892 08/10/2012 75 Citations

The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. (Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ) Paediatr Anaesth 2011 Apr;21(4):441-53 PMID: 21306473 SCOPUS ID: 2-s2.0-79952471592 02/11/2011 22 Citations

Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. (Mustapic S, Radocaj T, Sanchez A, Dogas Z, Stucke AG, Hopp FA, Stuth EA, Zuperku EJ) J Neurophysiol 2010 Jan;103(1):409-18 PMID: 19906886 PMCID: PMC2807229 SCOPUS ID: 2-s2.0-74049097521 11/13/2009 55 Citations

Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo. (Sanchez A, Mustapic S, Zuperku EJ, Stucke AG, Hopp FA, Stuth EA) J Neurophysiol 2009 Mar;101(3):1211-21 PMID: 19091929 PMCID: PMC2666418 SCOPUS ID: 2-s2.0-64749116760 12/19/2008 5 Citations

Opioid receptors on bulbospinal respiratory neurons are not activated during neuronal depression by clinically relevant opioid concentrations. (Stucke AG, Zuperku EJ, Sanchez A, Tonkovic-Capin M, Tonkovic-Capin V, Mustapic S, Stuth EA) J Neurophysiol 2008 Nov;100(5):2878-88 PMID: 18815346 PMCID: PMC2585400 SCOPUS ID: 2-s2.0-57049139355 09/26/2008 26 Citations

Anesthetic effects on synaptic transmission and gain control in respiratory control. (Stuth EA, Stucke AG, Brandes IF, Zuperku EJ) Respir Physiol Neurobiol 2008 Dec 10;164(1-2):151-9 PMID: 18583201 SCOPUS ID: 2-s2.0-53849141477 06/28/2008 13 Citations

Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo. (Zuperku EJ, Brandes IF, Stucke AG, Sanchez A, Hopp FA, Stuth EA) Adv Exp Med Biol 2008;605:279-84 PMID: 18085286 SCOPUS ID: 2-s2.0-38449120437 12/19/2007 7 Citations

Isoflurane depresses the response of inspiratory hypoglossal motoneurons to serotonin in vivo. (Brandes IF, Zuperku EJ, Stucke AG, Hopp FA, Jakovcevic D, Stuth EA) Anesthesiology 2007 Apr;106(4):736-45 PMID: 17413911 SCOPUS ID: 2-s2.0-34147182706 04/07/2007 12 Citations

Retrograde labeling reveals extensive distribution of genioglossal motoneurons possessing 5-HT2A receptors throughout the hypoglossal nucleus of adult dogs. (Brandes IF, Zuperku EJ, Dean C, Hopp FA, Jakovcevic D, Stuth EA) Brain Res 2007 Feb 09;1132(1):110-9 PMID: 17188659 SCOPUS ID: 2-s2.0-33846193319 12/26/2006 9 Citations

Central pathways of pulmonary and lower airway vagal afferents. (Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR) J Appl Physiol (1985) 2006 Aug;101(2):618-27 PMID: 16645192 PMCID: PMC4503231 SCOPUS ID: 2-s2.0-33746724777 04/29/2006 410 Citations

Serotonergic modulation of inspiratory hypoglossal motoneurons in decerebrate dogs. (Brandes IF, Zuperku EJ, Stucke AG, Jakovcevic D, Hopp FA, Stuth EA) J Neurophysiol 2006 Jun;95(6):3449-59 PMID: 16495364 PMCID: PMC2582383 SCOPUS ID: 2-s2.0-33744938895 02/24/2006 29 Citations

Reflexes From the Lungs and Chest Wall (McCrimmon DR, Alheid GF, Zuperku EJ) Encyclopedia of Respiratory Medicine Four Volume Set 1 January 2006:618-626 SCOPUS ID: 2-s2.0-33746764678 01/01/2006 4 Citations

REFLEXES FROM THE LUNGS AND CHEST WALL (McCrimmon DR, Alheid GF, Zuperku EJ) Encyclopedia of Respiratory Medicine Volume 1 4 1 January 2006;1-4:V3-V3-626 SCOPUS ID: 2-s2.0-85181385316 01/01/2006 1 Citation

Sevoflurane depresses glutamatergic neurotransmission to brainstem inspiratory premotor neurons but not postsynaptic receptor function in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2005 Jul;103(1):50-6 PMID: 15983456 SCOPUS ID: 2-s2.0-21744446111 06/29/2005 17 Citations

Sevoflurane enhances gamma-aminobutyric acid type A receptor function and overall inhibition of inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Krolo M, Brandes IF, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2005 Jul;103(1):57-64 PMID: 15983457 SCOPUS ID: 2-s2.0-21744436491 06/29/2005 22 Citations

Central effects of general anesthesia (Stuth EAE, Zuperku EJ, Stucke AG) Pharmacology and Pathophysiology of the Control of Breathing 1 January 2005:571-652 SCOPUS ID: 2-s2.0-53849110694 01/01/2005 8 Citations

Subtype composition and responses of respiratory neurons in the pre-botzinger region to pulmonary afferent inputs in dogs. (Krolo M, Tonkovic-Capin V, Stucke AG, Stuth EA, Hopp FA, Dean C, Zuperku EJ) J Neurophysiol 2005 May;93(5):2674-87 PMID: 15601729 SCOPUS ID: 2-s2.0-17644375473 12/17/2004 28 Citations

Halothane enhances gamma-aminobutyric acid receptor type A function but does not change overall inhibition in inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Krolo M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2003 Dec;99(6):1303-12 PMID: 14639142 SCOPUS ID: 2-s2.0-0344420350 11/26/2003 6 Citations

Halothane depresses glutamatergic neurotransmission to brain stem inspiratory premotor neurons in a decerebrate dog model. (Stucke AG, Zuperku EJ, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Stuth EA) Anesthesiology 2003 Apr;98(4):897-905 PMID: 12657851 SCOPUS ID: 2-s2.0-0037381082 03/27/2003 12 Citations

Differential processing of excitation by GABAergic gain modulation in canine caudal ventral respiratory group neurons. (Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 2003 Feb;89(2):862-70 PMID: 12574464 SCOPUS ID: 2-s2.0-0037319226 02/08/2003 20 Citations

Gain modulation of respiratory neurons. (Zuperku EJ, McCrimmon DR) Respir Physiol Neurobiol 2002 Jul;131(1-2):121-33 PMID: 12107000 SCOPUS ID: 2-s2.0-0036302432 07/11/2002 46 Citations

Respiratory rhythm generation: converging concepts from in vitro and in vivo approaches? (Ramirez JM, Zuperku EJ, Alheid GF, Lieske SP, Ptak K, McCrimmon DR) Respir Physiol Neurobiol 2002 Jul;131(1-2):43-56 PMID: 12106994 SCOPUS ID: 2-s2.0-0036308415 07/11/2002 38 Citations

Effects of halothane and sevoflurane on inhibitory neurotransmission to medullary expiratory neurons in a decerebrate dog model. (Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2002 Apr;96(4):955-62 PMID: 11964605 SCOPUS ID: 2-s2.0-0036201402 04/20/2002 21 Citations

Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism. (Tonkovic-Capin V, Stucke AG, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 2001 Nov;86(5):2363-73 PMID: 11698526 SCOPUS ID: 2-s2.0-0035652623 11/08/2001 18 Citations

Effects of sevoflurane on excitatory neurotransmission to medullary expiratory neurons and on phrenic nerve activity in a decerebrate dog model. (Stucke AG, Stuth EA, Tonkovic-Capin V, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2001 Aug;95(2):485-91 PMID: 11506124 SCOPUS ID: 2-s2.0-0034894854 08/17/2001 31 Citations

Physiological and pharmacological properties of GABA-ergic gain modulation of canine ventral respiratory group (VRG) neurons (Zuperku EJ, Tonkovic-Capin V, Stuth EA, Stucke AG, Hopp FA, Tonkovic-Capin M, McCrimmon DR) Respiratory Research August 2001;2(Suppl 1) SCOPUS ID: 2-s2.0-85187157808 08/01/2001

Effects of halothane on excitatory neurotransmission to medullary expiratory neurons in a decerebrate dog model. (Stuth EA, Krolo M, Stucke AG, Tonkovic-Capin M, Tonkovic-Capin V, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 2000 Dec;93(6):1474-81 PMID: 11149443 SCOPUS ID: 2-s2.0-0033637316 01/10/2001 25 Citations

Effect of central CO(2) drive on lung inflation responses of expiratory bulbospinal neurons in dogs. (Tonkovic-Capin M, Zuperku EJ, Stuth EA, Bajic J, Dogas Z, Hopp FA) Am J Physiol Regul Integr Comp Physiol 2000 Nov;279(5):R1606-18 PMID: 11049842 SCOPUS ID: 2-s2.0-0033674077 10/26/2000 8 Citations

Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs. (Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) Am J Physiol Regul Integr Comp Physiol 2000 Aug;279(2):R639-49 PMID: 10938255 SCOPUS ID: 2-s2.0-0033859199 08/12/2000 35 Citations

Pattern formation and rhythm generation in the ventral respiratory group. (McCrimmon DR, Monnier A, Hayashi F, Zuperku EJ) Clin Exp Pharmacol Physiol 2000;27(1-2):126-31 PMID: 10696541 SCOPUS ID: 2-s2.0-0033973795 03/04/2000 54 Citations

Unraveling the mechanism for respiratory rhythm generation. (McCrimmon DR, Ramirez JM, Alford S, Zuperku EJ) Bioessays 2000 Jan;22(1):6-9 PMID: 10649284 SCOPUS ID: 2-s2.0-0033980340 01/29/2000 41 Citations

Effects of halothane on synaptic neurotransmission to medullary expiratory neurons in the ventral respiratory group of dogs. (Stuth EA, Krolo M, Tonkovic-Capin M, Hopp FA, Kampine JP, Zuperku EJ) Anesthesiology 1999 Sep;91(3):804-14 PMID: 10485792 SCOPUS ID: 2-s2.0-0032842471 09/15/1999 21 Citations

Differential roles of ionotropic glutamate receptors in canine medullary inspiratory neurons of the ventral respiratory group. (Krolo M, Stuth EA, Tonkovic-Capin M, Dogas Z, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 1999 Jul;82(1):60-8 PMID: 10400935 SCOPUS ID: 2-s2.0-0032771345 07/13/1999 33 Citations

Differential effects of GABAA receptor antagonists in the control of respiratory neuronal discharge patterns. (Dogas Z, Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ) J Neurophysiol 1998 Nov;80(5):2368-77 PMID: 9819249 SCOPUS ID: 2-s2.0-0031597393 11/18/1998 57 Citations

Improved method of canine decerebration. (Tonkovic-Capin M, Krolo M, Stuth EA, Hopp FA, Zuperku EJ) J Appl Physiol (1985) 1998 Aug;85(2):747-50 PMID: 9688755 SCOPUS ID: 2-s2.0-0031880079 08/04/1998 29 Citations

Dose-dependent effects of halothane on the phrenic nerve responses to acute hypoxia in vagotomized dogs. (Stuth EA, Dogas Z, Krolo M, Kampine JP, Hopp FA, Zuperku EJ) Anesthesiology 1997 Dec;87(6):1428-39 PMID: 9416728 SCOPUS ID: 2-s2.0-0031438490 01/07/1998 15 Citations

Effects of halothane on the phrenic nerve responses to carbon dioxide mediated by carotid body chemoreceptors in vagotomized dogs. (Stuth EA, Dogas Z, Krolo M, Kampine JP, Hopp FA, Zuperku EJ) Anesthesiology 1997 Dec;87(6):1440-9 PMID: 9416729 SCOPUS ID: 2-s2.0-0031441277 01/07/1998 8 Citations

Modulation of the synaptic drive to respiratory premotor and motor neurons. (McCrimmon DR, Zuperku EJ, Hayashi F, Dogas Z, Hinrichsen CF, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA) Respir Physiol 1997 Nov;110(2-3):161-76 PMID: 9407609 SCOPUS ID: 2-s2.0-0030687877 01/04/1998 83 Citations

Roles of n-methyl-d-aspartate (NMDA) and non-NMDA receptors in the mediation of excitatory inputs to inspiratory bulbospinal neurons in dogs (Krolo M, Dooas Z, Tonkovlc-Capin M, Stuth E, Hopp F, McCrimmon D, Zuperku E) FASEB Journal 1996;10(3):A643 SCOPUS ID: 2-s2.0-33749180006 12/01/1996

Reflex effects of stimulation of sympathetic afferents on the triangularis sterni. (Coon RL, Hopp FA, Zuperku EJ) Respir Physiol 1995 Dec;102(2-3):187-94 PMID: 8904010 SCOPUS ID: 2-s2.0-0029565794 12/01/1995 3 Citations

NMDA receptor-mediated transmission of carotid body chemoreceptor input to expiratory bulbospinal neurones in dogs. (Dogas Z, Stuth EA, Hopp FA, McCrimmon DR, Zuperku EJ) J Physiol 1995 Sep 15;487 ( Pt 3)(Pt 3):639-51 PMID: 8544127 PMCID: PMC1156651 SCOPUS ID: 2-s2.0-0029116655 09/15/1995 42 Citations

Dose-dependent effects of halothane on the carbon dioxide responses of expiratory and inspiratory bulbospinal neurons and the phrenic nerve activities in dogs. (Stuth EA, Tonkovic-Capin M, Kampine JP, Bajic J, Zuperku EJ) Anesthesiology 1994 Dec;81(6):1470-83 PMID: 7992917 SCOPUS ID: 2-s2.0-0027948491 12/01/1994 29 Citations

Interaction between chemoreceptor and stretch receptor inputs at medullary respiratory neurons. (Bajić J, Zuperku EJ, Tonković-Capin M, Hopp FA) Am J Physiol 1994 Jun;266(6 Pt 2):R1951-61 PMID: 8024052 SCOPUS ID: 2-s2.0-0028276675 06/01/1994 23 Citations

Expiratory bulbospinal neurons of dogs. I. Control of discharge patterns by pulmonary stretch receptors. (Bajić J, Zuperku EJ, Tonković-Capin M, Hopp FA) Am J Physiol 1992 Jun;262(6 Pt 2):R1075-86 PMID: 1621861 SCOPUS ID: 2-s2.0-0026694517 06/01/1992 25 Citations

Expiratory bulbospinal neurons of dogs. II. Laterality of responses to spatial and temporal pulmonary vagal inputs. (Tonković-Capin M, Zuperku EJ, Bajić J, Hopp FA) Am J Physiol 1992 Jun;262(6 Pt 2):R1087-95 PMID: 1621862 SCOPUS ID: 2-s2.0-0026710525 06/01/1992 6 Citations

Dose-dependent effects of isoflurane on the CO2 responses of expiratory medullary neurons and the phrenic nerve activities in dogs. (Stuth EA, Tonkovic-Capin M, Kampine JP, Zuperku EJ) Anesthesiology 1992 May;76(5):763-74 PMID: 1575345 SCOPUS ID: 2-s2.0-0026559939 05/01/1992 23 Citations

Respiratory responses to aortic and carotid chemoreceptor activation in the dog. (Hopp FA, Seagard JL, Bajić J, Zuperku EJ) J Appl Physiol (1985) 1991 Jun;70(6):2539-50 PMID: 1885448 SCOPUS ID: 2-s2.0-0025796589 06/01/1991 14 Citations

Reflex ventilatory effects of KCl stimulation of lung receptors with sympathetic afferents. (Coon RL, Clifford PS, Hopp FA, Zuperku EJ) Respir Physiol 1990 Dec;82(3):349-58 PMID: 1964240 SCOPUS ID: 2-s2.0-0025687950 12/01/1990 12 Citations

Processing of pulmonary afferent input patterns by respiratory I-beta neurons. (Bajić J, Zuperku EJ, Hopp FA) Am J Physiol 1989 Feb;256(2 Pt 2):R379-93 PMID: 2492772 SCOPUS ID: 2-s2.0-0024578844 02/01/1989 3 Citations

Control of discharge patterns of medullary respiratory neurons by pulmonary vagal afferent inputs. (Zuperku EJ, Hopp FA) Am J Physiol 1987 Dec;253(6 Pt 2):R809-20 PMID: 3425759 SCOPUS ID: 2-s2.0-0023568441 12/01/1987 6 Citations

Effect of arterial PCO2 on 2-[1-14C]deoxy-D-glucose uptake by feline cerebral arteries. (Kostreva DR, McNeely J, Zuperku EJ) J Appl Physiol (1985) 1986 Oct;61(4):1288-92 PMID: 3096936 SCOPUS ID: 2-s2.0-0022930456 10/01/1986

Mechanical effects of vasoactive drugs on carotid sinus. (Bell LB, Seagard JL, Zuperku EJ, Kampine JP) Am J Physiol 1986 Jun;250(6 Pt 2):R1074-80 PMID: 3717381 SCOPUS ID: 2-s2.0-0022516983 06/01/1986 5 Citations

Respiratory arrhythmias and airway CO2, lung receptors, and central inspiratory activity. (Coon RL, Zuperku EJ, Kampine JP) J Appl Physiol (1985) 1986 May;60(5):1713-21 PMID: 3086282 SCOPUS ID: 2-s2.0-0022503891 05/01/1986 8 Citations

Technique for continuous measurement of compliance in isolated vascular segments. (Bell LB, Zuperku EJ, Kampine JP) Am J Physiol 1986 Jan;250(1 Pt 2):R142-9 PMID: 3942248 SCOPUS ID: 2-s2.0-0022531352 01/01/1986

Autonomic modulation of refractoriness in canine specialized His-Purkinje system. (Turner LA, Zuperku EJ, Bosnjak ZJ, Kampine JP) Am J Physiol 1985 May;248(5 Pt 2):R515-23 PMID: 3993811 SCOPUS ID: 2-s2.0-0022065725 05/01/1985 8 Citations

On the relation between expiratory duration and subsequent inspiratory duration. (Zuperku EJ, Hopp FA) J Appl Physiol (1985) 1985 Feb;58(2):419-30 PMID: 2984159 SCOPUS ID: 2-s2.0-0021865438 02/01/1985 18 Citations

Systemic arterial pH servocontrolled ventilator simulation of the respiratory control system. (Coon RL, Zuperku EJ, Kampine JP) Respir Physiol 1984 Dec;58(3):345-50 PMID: 6441984 SCOPUS ID: 2-s2.0-0021686054 12/01/1984 1 Citation

Responses of medullary respiratory neurons to vagal input patterns in the dog (Zuperku EJ, Hopp FA) Federation Proceedings 1984;43(3) SCOPUS ID: 2-s2.0-18744435968 01/01/1984

Pulmonary denervation in the dog. (Clifford PS, Coon RL, von Colditz JH, Zuperku EJ, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1983 Jun;54(6):1451-6 PMID: 6874467 SCOPUS ID: 2-s2.0-0020595224 06/01/1983 7 Citations

A programmable electrical stimulator suitable for control of respiration studies. (Hopp FA, Zuperku EJ, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1983 Apr;54(4):1149-56 PMID: 6687882 SCOPUS ID: 2-s2.0-0020632226 04/01/1983 1 Citation

Central integration of pulmonary stretch receptor input in the control of expiration. (Zuperku EJ, Hopp FA, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1982 May;52(5):1296-315 PMID: 7096154 SCOPUS ID: 2-s2.0-0019984765 05/01/1982 41 Citations

Interrelationships among airway CO2, airway pressure, and breathing frequency. (Nilsestuen JO, Coon RL, Zuperku EJ, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1982 Jan;52(1):190-7 PMID: 6800986 SCOPUS ID: 2-s2.0-0019989359 01/01/1982 2 Citations

Measurement of dead space ventilation using a pHa servo-controlled ventilator. (Coon RL, Zuperku EJ, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1981 Jul;51(1):154-9 PMID: 7263410 SCOPUS ID: 2-s2.0-0019417857 07/01/1981 6 Citations

Segmental ventricular adjustments to brief periods of ischemia in the dog. (Bosnjak ZJ, Seagard JL, Zuperku EJ, Coon RL, Singh HM, Bamrah VS, Kampine JP) Can J Physiol Pharmacol 1981 Mar;59(3):287-92 PMID: 6261904 SCOPUS ID: 2-s2.0-0019435679 03/01/1981

Coarctation of the aorta and baroreceptor resetting. A study of carotid baroreceptor stimulus-response characteristics before and after surgical repair in the dog. (Igler FO, Boerboom LE, Werner PH, Donegan JH, Zuperku EJ, Bonchek LI, Kampine JP) Circ Res 1981 Mar;48(3):365-71 PMID: 7460210 03/01/1981

Coarctation of the aorta and baroreceptor resetting. A study of carotid baroreceptor stimulus-response characteristics before and after surgical repair in the dog (Igler FO, Boerboom LE, Werner PH, Donegan JH, Zuperku EJ, Bonchek LI, Kampine JP) Circulation Research 1981;48(3):365-371 SCOPUS ID: 2-s2.0-0019511299 01/01/1981 31 Citations

Effect of anodal blockade of myelinated fibers on vagal C-fiber afferents. (Hopp FA, Zuperku EJ, Coon RL, Kampine JP) Am J Physiol 1980 Nov;239(5):R454-62 PMID: 7435661 SCOPUS ID: 2-s2.0-0019084703 11/01/1980 24 Citations

Effect of sympathetic nerve stimulation on hypocapnic airway constriction. (Coon RL, Zuperku EJ, Kampine JP) Proc Soc Exp Biol Med 1980 May;164(1):63-8 PMID: 6769131 SCOPUS ID: 2-s2.0-0019230186 05/01/1980 2 Citations

In vivo changes in canine ventricular cardiac conduction during halothane anesthesia. (Turner LA, Zuperku EJ, Purtock RV, Kampine JP) Anesth Analg 1980 May;59(5):327-34 PMID: 7189379 SCOPUS ID: 2-s2.0-0018886486 05/01/1980 13 Citations

Cardiac, aortic, pericardial, and pulmonary receptors in the dog. (Peters SR, Kostreva DR, Armour JA, Zuperku EJ, Igler FO, Coon RL, Kampine JP) Cardiology 1980;65(2):85-100 PMID: 7363286 SCOPUS ID: 2-s2.0-0018888540 01/01/1980 16 Citations

Breathing frequency responses to pulmonary CO2 in an isolated lobe of the canine lung. (Nilsestuen JO, Coon RL, Igler FO, Zuperku EJ, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1979 Dec;47(6):1201-6 PMID: 536290 SCOPUS ID: 2-s2.0-0018577317 12/01/1979 7 Citations

Apnea, tachypnea, and hypotension elicited by cardiac vagal afferents. (Kostreva DR, Hopp FA, Zuperku EJ, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1979 Aug;47(2):312-8 PMID: 468686 SCOPUS ID: 2-s2.0-0018687645 08/01/1979 21 Citations

Acute coronary artery occlusion and cardiac sympathetic afferent nerve activity. (Bosnjak ZJ, Zuperku EJ, Coon RL, Kampine JP) Proc Soc Exp Biol Med 1979 Jun;161(2):142-8 PMID: 450919 SCOPUS ID: 2-s2.0-0018429349 06/01/1979 28 Citations

Halothane, tracheal compliance and upper-airway mechanoreceptors. (Palmer SK, Zuperku EJ, Bosnjak Z, Coon RL, Kampine JP) Anesthesiology 1978 Oct;49(4):260-5 PMID: 697080 SCOPUS ID: 2-s2.0-0018078181 10/01/1978

Systemic arterial blood pH servocontrol of mechanical ventilation. (Coon RL, Zuperku EJ, Kampine JP) Anesthesiology 1978 Sep;49(3):201-4 PMID: 28683 SCOPUS ID: 2-s2.0-0018120975 09/01/1978 21 Citations

Respiratory inhibition with sympathetic afferent stimulation in the canine and primate. (Kostreva DR, Hopp FA, Zuperku EJ, Igler FO, Coon RL, Kampine JP) J Appl Physiol Respir Environ Exerc Physiol 1978 May;44(5):718-24 PMID: 418050 SCOPUS ID: 2-s2.0-0018243353 05/01/1978 40 Citations

Receptors in the canine lung which respond to vascular pressure changes. (Igler FO, Coon RL, Zuperku EJ, Kampine JP) Proc Soc Exp Biol Med 1978 Jan;157(1):36-40 PMID: 202970 SCOPUS ID: 2-s2.0-0017855677 01/01/1978 1 Citation

Reflex effects of thoracic sympathetic afferent nerve stimulation on the kidney. (Purtock RV, von Colditz JH, Seagard JL, Igler FO, Zuperku EJ, Kampine JP) Am J Physiol 1977 Nov;233(5):H580-6 PMID: 920821 SCOPUS ID: 2-s2.0-0344882960 11/01/1977 11 Citations

Ventral root mapping of cardiac nerves in the canine using evoked potentials. (Kostreva DR, Zuperku EJ, Cusick JF, Kampine JP) Am J Physiol 1977 Jun;232(6):H590-5 PMID: 879297 SCOPUS ID: 2-s2.0-0017713555 06/01/1977 10 Citations

Response of left ventricular mechanoreceptors to changes in pressure and muscle length. (Purtock RV, Zuperku EJ, Peters SR, Coon RL, Kampine JP) Proc Soc Exp Biol Med 1977 Apr;154(4):500-4 PMID: 859855 SCOPUS ID: 2-s2.0-0017379812 04/01/1977 4 Citations

Effect of pulmonary vascular and airway PCO2 alterations on ventilation (Igler FO, Zuperku EJ, Coon RL) Federation Proceedings 1977;36(3):No.1153 SCOPUS ID: 2-s2.0-17444434878 01/01/1977

Measurement of dead space ventilation using a systemic arterial pH servocontrolled ventilator (Coon RL, Zuperku EJ, Kampine JP) Federation Proceedings 1977;36(3) SCOPUS ID: 2-s2.0-0017394066 01/01/1977

Cardiac vagal afferent reflex alteration of respiratory drive (Kostreva DR, Czarnecki D, Zuperku EJ) Federation Proceedings 1977;36(3):No.1148 SCOPUS ID: 2-s2.0-0017393296 01/01/1977

Cardiac responses to stimulation of thoracic afferents in the primate and canine. (Kostreva DR, Hess GL, Zuperku EJ, Neumark J, Coon RL, Kampine JP) Am J Physiol 1976 Oct;231(4):1279-84 PMID: 984213 SCOPUS ID: 2-s2.0-0017108116 10/01/1976 8 Citations

Tracheal afferent nerves. (Traxel RM, Prudlow WF, Kampine JP, Coon RL, Zuperku EJ) Ann Otol Rhinol Laryngol 1976;85(5 Pt.1):664-9 PMID: 984658 SCOPUS ID: 2-s2.0-0017124537 09/01/1976 5 Citations

Inhibition of respiratory drive with stimulation of thoracic sympathetic afferents (Kostreva DR, Zuperku EJ, Coon RL, Kampine JP) Federation Proceedings 1976;35(3):No.1919 SCOPUS ID: 2-s2.0-0017251450 01/01/1976

Sympathetic afferent nerve activity of right heart origin. (Kostreva DR, Zuperku EJ, Purtock RV, Coon RL, Kampine JP) Am J Physiol 1975 Oct;229(4):911-5 PMID: 1190333 SCOPUS ID: 2-s2.0-0016804611 10/01/1975 17 Citations

Pulmonary afferent activity recorded from sympathetic nerves. (Kostreva DR, Zuperku EJ, Hess GL, Coon RL, Kampine JP) J Appl Physiol 1975 Jul;39(1):37-40 PMID: 1150589 SCOPUS ID: 2-s2.0-0016799626 07/01/1975 57 Citations

Sympathetic afferent nerve activity of pulmonary origin (Kostreva DR, Zuperku EJ, Hess GL) Federation Proceedings 1975;34(3) SCOPUS ID: 2-s2.0-0016651760 01/01/1975 2 Citations

Sympathetic afferent nerve activity of left ventricular origin. (Hess GL, Zuperku EJ, Coon RL, Kampine JP) Am J Physiol 1974 Sep;227(3):543-6 PMID: 4416008 SCOPUS ID: 2-s2.0-0016204274 09/01/1974 21 Citations

Upper airway protective reflexes. (Frisk JL, Titulaer RJ, Kampine J, Zuperku EJ) Surg Forum 1974;25(0):501-3 PMID: 4439245 SCOPUS ID: 2-s2.0-0016164075 01/01/1974

Receptors in the lungs which respond to pulmonary vascular pressure changes (Igler FO, Zuperku EJ, Hakim TS, Smith JJ) Federation Proceedings 1974;33(3 I):1335 SCOPUS ID: 2-s2.0-0016187637 01/01/1974

Cardiac sympathetic afferent nerve activity of left ventricular origin (Hess GL, Zuperku EJ, Coon RL) Federation Proceedings 1973;32(3 (I)):654 SCOPUS ID: 2-s2.0-0015794340 01/01/1973

An on-line circuit for extraction of average evoked potentials from periodic noise. (Benoit HJ, Zuperku EJ, Sances A Jr, Larson SJ) J Assoc Adv Med Instrum 1972;6(4):279-82 PMID: 4626443 SCOPUS ID: 2-s2.0-0015368375 07/01/1972 1 Citation

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Edward J. Zuperku PhD, MS

Emeritus Professor

Publications (112)