Medical College of Wisconsin
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Elizabeth Sweeny PhD

Elizabeth Sweeny PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Cardiovascular Research Center

View Curriculum Vitae

Publications (26)

  • One academic health center's response to a freedom of expression controversy. (Raymond JR Sr, Michaelis LC, Mitchell AB, DeBisschop M, Drew EM, Fadumiye C, Fleury N, Horton K, Hughes D, Mier T, Singh A, Sweeny E, Witten A, Carroll H, Zundel MT, Maurana CA) Acad Med 2026 Jan 01;101(1):19-26 PMID: 41601312 SCOPUS ID: 2-s2.0-105033855149 01/28/2026    
  • Key roles of GAPDH, Hsp90, and NO in heme trafficking. (Stuehr DJ, Biswas P, Dai Y, Jayaram DT, Sinha PD, Sweeny EA, Ghosh A) J Inorg Biochem 2025 Sep 08;274:113066 PMID: 40961740 SCOPUS ID: 2-s2.0-105015835663 09/18/2025       1 Citation
  • Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH. (Jayaram DT, Sivaram P, Biswas P, Dai Y, Sweeny EA, Stuehr DJ) Nat Commun 2025 Aug 26;16(1):7972 PMID: 40858607 PMCID: PMC12381273 SCOPUS ID: 2-s2.0-105014169951 08/28/2025       3 Citations
  • Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH. (Jayaram DT, Sivaram P, Biswas P, Dai Y, Sweeny EA, Stuehr DJ) Res Sq 2024 May 03 PMID: 38746106 PMCID: PMC11092803 05/15/2024    
  • Functional interactions between NADPH oxidase 5 and actin. (Richter SM, Massman LC, Stuehr DJ, Sweeny EA) Front Cell Dev Biol 2023;11:1116833 PMID: 36776559 PMCID: PMC9909703 SCOPUS ID: 2-s2.0-85147764215 02/14/2023       7 Citations
  • New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals. (Stuehr DJ, Dai Y, Biswas P, Sweeny EA, Ghosh A) Biol Chem 2022 Nov 25;403(11-12):1005-1015 PMID: 36152339 PMCID: PMC10184026 SCOPUS ID: 2-s2.0-85139392791 09/25/2022       17 Citations
  • GAPDH is involved in the heme-maturation of myoglobin and hemoglobin. (Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A) FASEB J 2022 Feb;36(2):e22099 PMID: 34972240 PMCID: PMC9239731 SCOPUS ID: 2-s2.0-85123037483 01/01/2022       36 Citations
  • Nitric oxide and heme-NO stimulate superoxide production by NADPH oxidase 5. (Sweeny EA, Hunt AP, Batka AE, Schlanger S, Lehnert N, Stuehr DJ) Free Radic Biol Med 2021 Aug 20;172:252-263 PMID: 34139309 PMCID: PMC8355125 SCOPUS ID: 2-s2.0-85109100150 06/18/2021       14 Citations
  • Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones. (Sweeny EA, Schlanger S, Stuehr DJ) Redox Biol 2020 Sep;36:101656 PMID: 32738790 PMCID: PMC7394750 SCOPUS ID: 2-s2.0-85088630674 08/02/2020       17 Citations
  • GAPDH delivers heme to soluble guanylyl cyclase. (Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ) J Biol Chem 2020 Jun 12;295(24):8145-8154 PMID: 32358060 PMCID: PMC7294094 SCOPUS ID: 2-s2.0-85086495703 05/03/2020       51 Citations
  • Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting. (Sweeny EA, Tariq A, Gurpinar E, Go MS, Sochor MA, Kan ZY, Mayne L, Englander SW, Shorter J) J Biol Chem 2020 Feb 07;295(6):1517-1538 PMID: 31882541 PMCID: PMC7008382 SCOPUS ID: 2-s2.0-85079204211 12/29/2019       14 Citations
  • Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. (Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J) Cell Rep 2019 Aug 20;28(8):2080-2095.e6 PMID: 31433984 PMCID: PMC6750954 SCOPUS ID: 2-s2.0-85070688471 08/23/2019       33 Citations
  • Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases. (Durie CL, Lin J, Scull NW, Mack KL, Jackrel ME, Sweeny EA, Castellano LM, Shorter J, Lucius AL) Biophys J 2019 May 21;116(10):1856-1872 PMID: 31027887 PMCID: PMC6531783 SCOPUS ID: 2-s2.0-85064567361 04/28/2019       16 Citations
  • Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. (Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ) J Biol Chem 2018 Sep 14;293(37):14557-14568 PMID: 30012884 PMCID: PMC6139559 SCOPUS ID: 2-s2.0-85053291002 07/18/2018       110 Citations
  • Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. (Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J) Cell 2018 Apr 19;173(3):677-692.e20 PMID: 29677512 PMCID: PMC5911940 SCOPUS ID: 2-s2.0-85045775165 04/21/2018       392 Citations
  • Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells. (Ghosh A, Garee G, Sweeny EA, Nakamura Y, Stuehr DJ) Proc Natl Acad Sci U S A 2018 Feb 06;115(6):E1117-E1126 PMID: 29358373 PMCID: PMC5819442 SCOPUS ID: 2-s2.0-85041537342 01/24/2018       48 Citations
  • Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. (Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR) Science 2017 Jul 21;357(6348):273-279 PMID: 28619716 PMCID: PMC5770238 SCOPUS ID: 2-s2.0-85020493156 06/18/2017       208 Citations
  • Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures. (Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL) Biochemistry 2017 Apr 18;56(15):2071-2075 PMID: 28379007 PMCID: PMC5649362 SCOPUS ID: 2-s2.0-85020121050 04/06/2017       11 Citations
  • Formation of Nitrogenase NifDK Tetramers in the Mitochondria of Saccharomyces cerevisiae. (Burén S, Young EM, Sweeny EA, Lopez-Torrejón G, Veldhuizen M, Voigt CA, Rubio LM) ACS Synth Biol 2017 Jun 16;6(6):1043-1055 PMID: 28221768 PMCID: PMC5477005 SCOPUS ID: 2-s2.0-85020844594 02/22/2017       73 Citations
  • Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. (Sweeny EA, Shorter J) J Mol Biol 2016 May 08;428(9 Pt B):1870-85 PMID: 26608812 PMCID: PMC4860052 SCOPUS ID: 2-s2.0-84960926930 11/27/2015       71 Citations
  • The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. (Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J) Mol Cell 2015 Mar 05;57(5):836-849 PMID: 25620563 PMCID: PMC4623595 SCOPUS ID: 2-s2.0-84924037150 01/27/2015       83 Citations
  • Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. (Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J) J Biol Chem 2014 Jan 10;289(2):848-67 PMID: 24280225 PMCID: PMC3887210 SCOPUS ID: 2-s2.0-84891905978 11/28/2013       43 Citations
  • Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. (DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J) Cell 2012 Nov 09;151(4):778-793 PMID: 23141537 PMCID: PMC3496281 SCOPUS ID: 2-s2.0-84869017593 11/13/2012       148 Citations
  • Purification of hsp104, a protein disaggregase. (Sweeny EA, DeSantis ME, Shorter J) J Vis Exp 2011 Sep 30(55) PMID: 21989490 PMCID: PMC3230206 SCOPUS ID: 2-s2.0-80053910072 10/13/2011       19 Citations
  • A synergistic small-molecule combination directly eradicates diverse prion strain structures. (Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J) Nat Chem Biol 2009 Dec;5(12):936-46 PMID: 19915541 PMCID: PMC2909773 SCOPUS ID: 2-s2.0-73549103148 11/17/2009       89 Citations
  • Prion proteostasis: Hsp104 meets its supporting cast. (Sweeny EA, Shorter J) Prion 2008;2(4):135-40 PMID: 19242125 PMCID: PMC2658762 SCOPUS ID: 2-s2.0-63049114323 02/27/2009       44 Citations
    • Last update: 01/29/2026