Medical College of Wisconsin
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Emily M. Eshleman PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Pediatrics Gastroenterology

Research Areas of Interest

  • Allergy and Immunology
  • Asthma
  • Colitis, Ulcerative
  • Crohn Disease
  • Dysbiosis
  • Inflammatory Bowel Diseases
  • Intestinal Mucosa
  • Microbiota
  • Type 2 immunity
  • Epithelial-microbiota interactions
  • tuft cells
  • type 2 innate lymphoid cells
  • epithelial-immune interactions

    • Research Experience

  • Allergy and Immunology
  • immunology
  • mucosal immunology

    • Publications (20)

  • Tuft cells protect against intestinal inflammation through histone deacetylase 3. (Eshleman EM, Rice T, Waddell A, Kumar S, Didriksen BJ, Engleman L, Vidyant S, Sayed M, Karns R, Lim HW, Denson LA, Alenghat T) Mucosal Immunol 2026 Jun 03:100356 PMID: 42242519 SCOPUS ID: 2-s2.0-105041067576 06/05/2026    
  • Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. (Stevens J, Culberson E, Kinder J, Ramiriqui A, Gray J, Bonfield M, Shao TY, Al Gharaibeh F, Peterson L, Steinmeyer S, Eshleman EM, Negi S, Zacharias W, Pryhuber G, Paul O, Sengupta S, Alenghat T, Way SS, Deshmukh H) Cell 2025 Aug 07;188(16):4239-4256.e19 PMID: 40494345 PMCID: PMC12335363 SCOPUS ID: 2-s2.0-105007602567 06/11/2025       17 Citations
  • Epithelial regulation of microbiota-immune cell dynamics. (Didriksen BJ, Eshleman EM, Alenghat T) Mucosal Immunol 2024 Apr;17(2):303-313 PMID: 38428738 PMCID: PMC11412483 SCOPUS ID: 2-s2.0-85187354253 03/02/2024       38 Citations
  • Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. (Eshleman EM, Rice T, Potter C, Waddell A, Hashimoto-Hill S, Woo V, Field S, Engleman L, Lim HW, Schumacher MA, Frey MR, Denson LA, Finkelman FD, Alenghat T) Immunity 2024 Feb 13;57(2):319-332.e6 PMID: 38295798 PMCID: PMC10901458 SCOPUS ID: 2-s2.0-85184758677 02/01/2024       108 Citations
  • Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. (Shao TY, Jiang TT, Stevens J, Russi AE, Troutman TD, Bernieh A, Pham G, Erickson JJ, Eshleman EM, Alenghat T, Jameson SC, Hogquist KA, Weaver CT, Haslam DB, Deshmukh H, Way SS) Cell Rep 2023 Nov 28;42(11):113323 PMID: 37889750 PMCID: PMC10822050 SCOPUS ID: 2-s2.0-85174807435 10/27/2023       5 Citations
  • Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. (Velez Lopez A, Waddell A, Antonacci S, Castillo D, Santucci N, Ollberding NJ, Eshleman EM, Denson LA, Alenghat T) Neurogastroenterol Motil 2023 Dec;35(12):e14681 PMID: 37736865 PMCID: PMC10841278 SCOPUS ID: 2-s2.0-85171759742 09/22/2023       4 Citations
  • Cleaving an epithelial path to food tolerance. (Eshleman EM, Alenghat T) Cell Res 2023 Dec;33(12):896-897 PMID: 37491601 PMCID: PMC10709587 SCOPUS ID: 2-s2.0-85165701203 07/26/2023    
  • IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. (Overcast GR, Meibers HE, Eshleman EM, Saha I, Waggoner L, Patel KN, Jain VG, Haslam DB, Alenghat T, VanDussen KL, Pasare C) J Exp Med 2023 Jun 05;220(6) PMID: 36976181 PMCID: PMC10067527 SCOPUS ID: 2-s2.0-85151168201 03/29/2023       17 Citations
  • Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. (Eshleman EM, Shao TY, Woo V, Rice T, Engleman L, Didriksen BJ, Whitt J, Haslam DB, Way SS, Alenghat T) J Clin Invest 2023 Feb 15;133(4) PMID: 36602872 PMCID: PMC9927950 SCOPUS ID: 2-s2.0-85148114388 01/06/2023       48 Citations
  • Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. (Fawad JA, Luzader DH, Hanson GF, Moutinho TJ Jr, McKinney CA, Mitchell PG, Brown-Steinke K, Kumar A, Park M, Lee S, Bolick DT, Medlock GL, Zhao JY, Rosselot AE, Chou CJ, Eshleman EM, Alenghat T, Hong CI, Papin JA, Moore SR) Gastroenterology 2022 Nov;163(5):1377-1390.e11 PMID: 35934064 PMCID: PMC11551968 SCOPUS ID: 2-s2.0-85140087418 08/08/2022       137 Citations
  • Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. (Woo V, Eshleman EM, Hashimoto-Hill S, Whitt J, Wu SE, Engleman L, Rice T, Karns R, Qualls JE, Haslam DB, Vallance BA, Alenghat T) Cell Host Microbe 2021 Dec 08;29(12):1744-1756.e5 PMID: 34678170 PMCID: PMC8667605 SCOPUS ID: 2-s2.0-85117839880 10/23/2021       82 Citations
  • Myeloid cell responsiveness to interferon-gamma is sufficient for initial resistance to Listeria monocytogenes. (Eshleman EM, Bortell N, McDermott DS, Crisler WJ, Lenz LL) Curr Res Immunol 2020 Dec;1:1-9 PMID: 34337387 PMCID: PMC8323841 SCOPUS ID: 2-s2.0-85132275813 08/03/2021       6 Citations
  • Epithelial sensing of microbiota-derived signals. (Eshleman EM, Alenghat T) Genes Immun 2021 Oct;22(5-6):237-246 PMID: 33824498 PMCID: PMC8492766 SCOPUS ID: 2-s2.0-85103677164 04/08/2021       24 Citations
  • Microbiota-derived metabolite promotes HDAC3 activity in the gut. (Wu SE, Hashimoto-Hill S, Woo V, Eshleman EM, Whitt J, Engleman L, Karns R, Denson LA, Haslam DB, Alenghat T) Nature 2020 Oct;586(7827):108-112 PMID: 32731255 PMCID: PMC7529926 SCOPUS ID: 2-s2.0-85088807655 07/31/2020       216 Citations
  • Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness. (Crisler WJ, Eshleman EM, Lenz LL) Life Sci Alliance 2019 Oct;2(5) PMID: 31585982 PMCID: PMC6778285 SCOPUS ID: 2-s2.0-85072940574 10/06/2019       6 Citations
  • Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression. (Woo V, Eshleman EM, Rice T, Whitt J, Vallance BA, Alenghat T) Front Immunol 2019;10:928 PMID: 31134059 PMCID: PMC6514056 SCOPUS ID: 2-s2.0-85067016663 05/28/2019       21 Citations
  • Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. (Eshleman EM, Delgado C, Kearney SJ, Friedman RS, Lenz LL) PLoS Pathog 2017 May;13(5):e1006388 PMID: 28542482 PMCID: PMC5457163 SCOPUS ID: 2-s2.0-85020198451 05/26/2017       26 Citations
  • Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. (Eshleman EM, Lenz LL) Front Immunol 2014;5:431 PMID: 25309533 PMCID: PMC4161047 SCOPUS ID: 2-s2.0-84918801828 10/14/2014       39 Citations
  • Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. (Kearney SJ, Delgado C, Eshleman EM, Hill KK, O'Connor BP, Lenz LL) J Immunol 2013 Sep 15;191(6):3384-92 PMID: 23935197 PMCID: PMC3777655 SCOPUS ID: 2-s2.0-84884227097 08/13/2013       47 Citations
  • Human anti-varicella-zoster virus (VZV) recombinant monoclonal antibody produced after Zostavax immunization recognizes the gH/gL complex and neutralizes VZV infection. (Birlea M, Owens GP, Eshleman EM, Ritchie A, Traktinskiy I, Bos N, Seitz S, Azarkh Y, Mahalingam R, Gilden D, Cohrs RJ) J Virol 2013 Jan;87(1):415-21 PMID: 23077312 PMCID: PMC3536365 SCOPUS ID: 2-s2.0-84872000832 10/19/2012       20 Citations
    • Last update: 07/06/2026