Faculty Collaboration Database

Medical College of Wisconsin

CTSI Research Informatics REDCap

Frederick Freitag DO

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Neurology

Member of the Neuroscience Research Center

Send Message

Request Meeting

View Curriculum Vitae

Publications (156)

The efficacy and safety of sumatriptan intranasal powder in adults with acute migraine. (Freitag FG, Shumate DA) Expert Rev Neurother 2016 Jul;16(7):743-7 PMID: 27260875 SCOPUS ID: 2-s2.0-84976430938 06/05/2016 4 Citations

Cluster Headache (Freitag FG, Florczak J) Headache and Migraine Biology and Management March 13, 2015:135-148 SCOPUS ID: 2-s2.0-84940053145 03/13/2015

Current and investigational drugs for the prevention of migraine in adults and children. (Freitag FG, Shumate D) CNS Drugs 2014 Oct;28(10):921-7 PMID: 25253573 SCOPUS ID: 2-s2.0-84922005372 09/26/2014 7 Citations

Medical management of adult headache. (Freitag FG, Schloemer F) Otolaryngol Clin North Am 2014 Apr;47(2):221-37 PMID: 24680490 SCOPUS ID: 2-s2.0-84897032294 04/01/2014 17 Citations

Migraine disability, healthcare utilization, and expenditures following treatment in a tertiary headache center. (Freitag FG, Lyss H, Nissan GR) Proc (Bayl Univ Med Cent) 2013 Oct;26(4):363-7 PMID: 24082410 PMCID: PMC3777091 10/02/2013

A review of needle-free sumatriptan injection for rapid control of migraine. (Rothrock JF, Freitag FG, Farr SJ, Smith EF 3rd) Headache 2013 Sep;53 Suppl 2:21-33 PMID: 24024600 SCOPUS ID: 2-s2.0-84893974314 09/18/2013 7 Citations

SumaRT/Nap vs naproxen sodium in treatment and disease modification of migraine: a pilot study. (Cady R, O'Carroll P, Dexter K, Freitag F, Shade CL) Headache 2014 Jan;54(1):67-79 PMID: 24021029 SCOPUS ID: 2-s2.0-84892374152 09/12/2013 12 Citations

Treatment of chronic migraine: a 3-month comparator study of naproxen sodium vs SumaRT/Nap. (Cady R, Nett R, Dexter K, Freitag F, Beach ME, Manley HR) Headache 2014 Jan;54(1):80-93 PMID: 24020994 SCOPUS ID: 2-s2.0-84892372548 09/12/2013 16 Citations

Why do migraines often decrease as we age? (Freitag FG) Curr Pain Headache Rep 2013 Oct;17(10):366 PMID: 23996722 SCOPUS ID: 2-s2.0-84883110268 09/03/2013 7 Citations

Author response. (Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C) Neurology 2013 Feb 26;80(9):868-9 PMID: 23565553 SCOPUS ID: 2-s2.0-84876302475 04/09/2013 1 Citation

Managing and treating tension-type headache. (Freitag F) Med Clin North Am 2013 Mar;97(2):281-92 PMID: 23419626 SCOPUS ID: 2-s2.0-84873895168 02/20/2013 34 Citations

Author response (Silberstein SD, Freitag F, Dodick DW, Argoff C) Neurology 18 September 2012;79(12):1301-1302 SCOPUS ID: 2-s2.0-84867564901 09/18/2012

Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. (Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E, Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society) Neurology 2012 Apr 24;78(17):1346-53 PMID: 22529203 PMCID: PMC3335449 SCOPUS ID: 2-s2.0-84860705677 04/25/2012 296 Citations

Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. (Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E, Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society) Neurology 2012 Apr 24;78(17):1337-45 PMID: 22529202 PMCID: PMC3335452 SCOPUS ID: 2-s2.0-84860767840 04/25/2012 804 Citations

Headache: advances in understanding and treatment. (Freitag FG) Lancet Neurol 2012 Jan;11(1):10-2 PMID: 22172613 SCOPUS ID: 2-s2.0-83455249867 12/17/2011

OnabotulinumtoxinA improves quality of life and reduces impact of chronic migraine. (Lipton RB, Varon SF, Grosberg B, McAllister PJ, Freitag F, Aurora SK, Dodick DW, Silberstein SD, Diener HC, DeGryse RE, Nolan ME, Turkel CC) Neurology 2011 Oct 11;77(15):1465-72 PMID: 21956721 SCOPUS ID: 2-s2.0-82955236200 10/01/2011 128 Citations

Sumatriptan needle-free subcutaneous (Sumavel(®) DosePro™) approved for the acute treatment of migraine, with or without aura, and cluster headaches. (Freitag FG) Expert Rev Neurother 2011 Apr;11(4):481-90 PMID: 21469920 SCOPUS ID: 2-s2.0-79953735515 04/08/2011 12 Citations

The authors reply (Rapoport AM, Freitag F, Pearlman SH) CNS Drugs 2011;25(2):171-173 SCOPUS ID: 2-s2.0-78951488024 01/28/2011

The authors reply (Rapoport AM, Freitag F, Pearlman SH) CNS Drugs 2011;25(2):171-174 SCOPUS ID: 2-s2.0-78951491471 01/01/2011

Topiramate intervention to prevent transformation of episodic migraine: the topiramate INTREPID study. (Lipton RB, Silberstein S, Dodick D, Cady R, Freitag F, Mathew N, Biondi DM, Ascher S, Olson WH, Hulihan J) Cephalalgia 2011 Jan;31(1):18-30 PMID: 20974598 SCOPUS ID: 2-s2.0-79751483735 10/27/2010 55 Citations

Innovative delivery systems for migraine: the clinical utility of a transdermal patch for the acute treatment of migraine. (Rapoport AM, Freitag F, Pearlman SH) CNS Drugs 2010 Nov;24(11):929-40 PMID: 20932065 SCOPUS ID: 2-s2.0-77957872874 10/12/2010 49 Citations

OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. (Aurora SK, Dodick DW, Turkel CC, DeGryse RE, Silberstein SD, Lipton RB, Diener HC, Brin MF, PREEMPT 1 Chronic Migraine Study Group) Cephalalgia 2010 Jul;30(7):793-803 PMID: 20647170 SCOPUS ID: 2-s2.0-77953194100 07/22/2010 808 Citations

OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. (Diener HC, Dodick DW, Aurora SK, Turkel CC, DeGryse RE, Lipton RB, Silberstein SD, Brin MF, PREEMPT 2 Chronic Migraine Study Group) Cephalalgia 2010 Jul;30(7):804-14 PMID: 20647171 SCOPUS ID: 2-s2.0-77953223552 07/22/2010 855 Citations

Importance of botulinum toxin for prevention of migraine. (Freitag FG) Expert Rev Neurother 2010 Mar;10(3):339-40 PMID: 20187855 SCOPUS ID: 2-s2.0-77649289633 03/02/2010 3 Citations

Needle-free subcutaneous sumatriptan (Sumavel DosePro): bioequivalence and ease of use. (Brandes JL, Cady RK, Freitag FG, Smith TR, Chandler P, Fox AW, Linn L, Farr SJ) Headache 2009;49(10):1435-44 PMID: 19849720 SCOPUS ID: 2-s2.0-71049120558 10/24/2009 50 Citations

Topiramate treatment of chronic migraine: a randomized, placebo-controlled trial of quality of life and other efficacy measures. (Silberstein S, Lipton R, Dodick D, Freitag F, Mathew N, Brandes J, Bigal M, Ascher S, Morein J, Wright P, Greenberg S, Hulihan J) Headache 2009 Sep;49(8):1153-62 PMID: 19719543 SCOPUS ID: 2-s2.0-69449083213 09/02/2009 120 Citations

Topiramate versus amitriptyline in migraine prevention: a 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group noninferiority trial in adult migraineurs. (Dodick DW, Freitag F, Banks J, Saper J, Xiang J, Rupnow M, Biondi D, Greenberg SJ, Hulihan J, CAPSS-277 Investigator Group) Clin Ther 2009 Mar;31(3):542-59 PMID: 19393844 SCOPUS ID: 2-s2.0-64849112151 04/28/2009 133 Citations

Evaluation of carisbamate for the treatment of migraine in a randomized, double-blind trial. (Cady RK, Mathew N, Diener HC, Hu P, Haas M, Novak GP, Study Group) Headache 2009 Feb;49(2):216-26 PMID: 19222595 SCOPUS ID: 2-s2.0-59449089769 02/19/2009 37 Citations

Allodynia-associated symptoms, pain intensity and time to treatment: predicting treatment response in acute migraine intervention. (Cady RK, Freitag FG, Mathew NT, Elkind AH, Mao L, Fisher AC, Biondi DM, Finlayson G, Greenberg SJ, Hulihan JF) Headache 2009 Mar;49(3):350-63 PMID: 19220503 SCOPUS ID: 2-s2.0-61349189613 02/18/2009 29 Citations

Serotonin syndrome risks when combining SSRI/SNRI drugs and triptans: is the FDA's alert warranted? (Wenzel RG, Tepper S, Korab WE, Freitag F) Ann Pharmacother 2008 Nov;42(11):1692-6 PMID: 18957623 SCOPUS ID: 2-s2.0-55949090829 10/30/2008 22 Citations

Epidemiology, risk factors, and treatment of chronic migraine: a focus on topiramate. (Silberstein S, Diener HC, Lipton R, Goadsby P, Dodick D, Bussone G, Freitag F, Schwalen S, Ascher S, Morein J, Greenberg S, Biondi D, Hulihan J) Headache 2008 Jul;48(7):1087-95 PMID: 18687081 SCOPUS ID: 2-s2.0-46749137929 08/09/2008 33 Citations

Cumulative lifetime migraine incidence in women and men. (Stewart WF, Wood C, Reed ML, Roy J, Lipton RB, AMPP Advisory Group) Cephalalgia 2008 Nov;28(11):1170-8 PMID: 18644028 SCOPUS ID: 2-s2.0-53549126613 07/23/2008 367 Citations

Efficacy and tolerability of coadministration of rizatriptan and acetaminophen vs rizatriptan or acetaminophen alone for acute migraine treatment. (Freitag F, Diamond M, Diamond S, Janssen I, Rodgers A, Skobieranda F) Headache 2008 Jun;48(6):921-30 PMID: 18572432 SCOPUS ID: 2-s2.0-42949144836 06/24/2008 29 Citations

Prevalence and characteristics of allodynia in headache sufferers: a population study. (Bigal ME, Ashina S, Burstein R, Reed ML, Buse D, Serrano D, Lipton RB, AMPP Group) Neurology 2008 Apr 22;70(17):1525-33 PMID: 18427069 PMCID: PMC2664547 SCOPUS ID: 2-s2.0-42549086103 04/23/2008 322 Citations

Effect of melasma on quality of life in a sample of women living in southern Brazil. (Freitag FM, Cestari TF, Leopoldo LR, Paludo P, Boza JC) J Eur Acad Dermatol Venereol 2008 Jun;22(6):655-62 PMID: 18410339 SCOPUS ID: 2-s2.0-43649089803 04/16/2008 89 Citations

Pharmacoeconomic benefits of almotriptan in the acute treatment of migraine. (Freitag FG) Expert Rev Pharmacoecon Outcomes Res 2008 Apr;8(2):105-10 PMID: 20528399 SCOPUS ID: 2-s2.0-46949091363 04/01/2008 2 Citations

Effect of early intervention with almotriptan vs placebo on migraine-associated functional disability: results from the AEGIS Trial. (Freitag F, Smith T, Mathew N, Rupnow M, Greenberg S, Mao L, Finlayson G, Wright P, Biondi D, AEGIS Investigator Study Group) Headache 2008 Mar;48(3):341-54 PMID: 18302700 SCOPUS ID: 2-s2.0-42049099690 02/28/2008 27 Citations

Analysis of safety and tolerability data obtained from over 1,500 patients receiving topiramate for migraine prevention in controlled trials. (Adelman J, Freitag FG, Lainez M, Shi Y, Ascher S, Mao L, Greenberg S, Hulihan J) Pain Med 2008 Mar;9(2):175-85 PMID: 18298700 SCOPUS ID: 2-s2.0-39649084396 02/27/2008 46 Citations

The impact of topiramate on health-related quality of life indicators in chronic migraine. (Dodick DW, Silberstein S, Saper J, Freitag FG, Cady RK, Rapoport AM, Mathew NT, Hulihan J, Crivera C, Rupnow MF, Mao L, Finlayson G, Greenberg SJ) Headache 2007;47(10):1398-408 PMID: 18052949 SCOPUS ID: 2-s2.0-36749067884 12/07/2007 65 Citations

Elimination of migraine-associated nausea in patients treated with rizatriptan orally disintegrating tablet (ODT): a randomized, double-blind, placebo-controlled study. (Freitag F, Taylor FR, Hamid MA, Rodgers A, Hustad CM, Ramsey KE, Skobieranda F) Headache 2008 Mar;48(3):368-77 PMID: 18047500 SCOPUS ID: 2-s2.0-42049118734 12/01/2007 8 Citations

Botulinum Toxin Type A in the treatment of chronic migraine without medication overuse. (Freitag FG, Diamond S, Diamond M, Urban G) Headache 2008 Feb;48(2):201-9 PMID: 18042229 SCOPUS ID: 2-s2.0-38849192498 11/29/2007 92 Citations

Newer aspects of migraine preventive therapies (Freitag FG) Drug Development Research September 2007;68(6):315-320 SCOPUS ID: 2-s2.0-38149109044 09/01/2007 1 Citation

Inpatient management of medication overuse headache and refractory headache pain (Freitag FG) Headache and Pain Diagnostic Challenges Current Therapy September 2007;18(3):100-104 SCOPUS ID: 2-s2.0-35348885583 09/01/2007

The cycle of migraine: patients' quality of life during and between migraine attacks. (Freitag FG) Clin Ther 2007 May;29(5):939-949 PMID: 17697913 SCOPUS ID: 2-s2.0-34547673154 08/19/2007 80 Citations

Analysis of pooled data from two pivotal controlled trials on the efficacy of topiramate in the prevention of migraine. (Freitag FG, Forde G, Neto W, Wang DZ, Schmitt J, Wu SC, Hulihan J) J Am Osteopath Assoc 2007 Jul;107(7):251-8 PMID: 17682112 SCOPUS ID: 2-s2.0-34548030182 08/08/2007 12 Citations

Time course of adverse events most commonly associated with topiramate for migraine prevention. (Láinez MJ, Freitag FG, Pfeil J, Ascher S, Olson WH, Schwalen S) Eur J Neurol 2007 Aug;14(8):900-6 PMID: 17662012 SCOPUS ID: 2-s2.0-34547132775 07/31/2007 51 Citations

Quality of care measures for migraine: a comprehensive review. (Gagne JJ, Leas B, Lofland JH, Goldfarb N, Freitag F, Silberstein S) Dis Manag 2007 Jun;10(3):138-46 PMID: 17590144 SCOPUS ID: 2-s2.0-34548602013 06/26/2007 8 Citations

Botulinum toxin type A in chronic migraine. (Freitag FG) Expert Rev Neurother 2007 May;7(5):463-70 PMID: 17492897 SCOPUS ID: 2-s2.0-34248372532 05/12/2007 9 Citations

Effect of pain intensity and time to administration on responsiveness to almotriptan: results from AXERT 12.5 mg Time Versus Intensity Migraine Study (AIMS). (Freitag FG, Finlayson G, Rapoport AM, Elkind AH, Diamond ML, Unger JR, Fisher AC, Armstrong RB, Hulihan JF, Greenberg SJ, AIMS Investigators) Headache 2007 Apr;47(4):519-30 PMID: 17445101 SCOPUS ID: 2-s2.0-34247243618 04/21/2007 37 Citations

Pharmacological approaches to managing migraine and associated comorbidities--clinical considerations for monotherapy versus polytherapy. (Silberstein SD, Dodick D, Freitag F, Pearlman SH, Hahn SR, Scher AI, Lipton RB) Headache 2007 Apr;47(4):585-99 PMID: 17445108 SCOPUS ID: 2-s2.0-34247341837 04/21/2007 76 Citations

Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. (Silberstein SD, Lipton RB, Dodick DW, Freitag FG, Ramadan N, Mathew N, Brandes JL, Bigal M, Saper J, Ascher S, Jordan DM, Greenberg SJ, Hulihan J, Topiramate Chronic Migraine Study Group) Headache 2007 Feb;47(2):170-80 PMID: 17300356 SCOPUS ID: 2-s2.0-33846998336 02/16/2007 466 Citations

Migraine prevalence, disease burden, and the need for preventive therapy. (Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF, AMPP Advisory Group) Neurology 2007 Jan 30;68(5):343-9 PMID: 17261680 SCOPUS ID: 2-s2.0-33846576913 01/31/2007 1996 Citations

Sumatriptan 6 mg subcutaneous as an effective migraine treatment in patients with cutaneous allodynia who historically fail to respond to oral triptans. (Diamond S, Freitag FG, Feoktistov A, Nissan G) J Headache Pain 2007 Feb;8(1):13-8 PMID: 17221340 PMCID: PMC3476122 SCOPUS ID: 2-s2.0-33947426785 01/16/2007 17 Citations

Evidence-based understanding of medication-overuse headache: clinical implications. (Dodick D, Freitag F) Headache 2006 Nov;46 Suppl 4:S202-11 PMID: 17078852 SCOPUS ID: 2-s2.0-33750452267 11/03/2006 81 Citations

Subcutaneous sumatriptan as a successful treatment for migraine associated with allodynia (Diamond S, Freitag FG, Feoktistov A, Nissan G) Headache and Pain Diagnostic Challenges Current Therapy November 2006;17(4):174-180 SCOPUS ID: 2-s2.0-34147175426 11/01/2006 1 Citation

Sumatriptan 6 MG subcutaneous as an effective migraine treatment in patients who historically fail to respond to oral triptans (Diamond S, Freitag FG, Feoktistov A, Nissan G) Headache and Pain Diagnostic Challenges Current Therapy September 2006;17(3):138-144 SCOPUS ID: 2-s2.0-33750455857 09/01/2006

Response [7] (Freitag FG, Biondi DM, Nissan GR, Winner PK) Journal of the American Osteopathic Association 2006;106(7):424-425 SCOPUS ID: 2-s2.0-33747488122 08/25/2006 1 Citation

Tension-type headache: Diagnosis and differential diagnostic considerations (Freitag FG) Headache and Pain Diagnostic Challenges Current Therapy June 2006;17(2):59-64 SCOPUS ID: 2-s2.0-33745211040 06/01/2006

Oral sumatriptan for the acute treatment of probable migraine: first randomized, controlled study. (Tepper SJ, Cady R, Dodick D, Freitag FG, Hutchinson SL, Twomey C, Kuhn TA) Headache 2006 Jan;46(1):115-24 PMID: 16412159 SCOPUS ID: 2-s2.0-33645097439 01/18/2006 16 Citations

Tension-Type Headache (Freitag FG) Pain Management December 2006;1:464-473 SCOPUS ID: 2-s2.0-84902220641 01/01/2006

Tramadol/acetaminophen for the treatment of acute migraine pain: findings of a randomized, placebo-controlled trial. (Silberstein SD, Freitag FG, Rozen TD, Kudrow DB, Hewitt DJ, Jordan DM, Fisher AC, Rosenthal NR, CAPSS-223 Investigators) Headache 2005;45(10):1317-27 PMID: 16324164 SCOPUS ID: 2-s2.0-33645727768 12/06/2005 39 Citations

Which preventive therapies should i use for which patients? (Freitag F) Managed Care Interface 2005;1(SUPPL. 2):16-23 SCOPUS ID: 2-s2.0-33846881761 12/01/2005

Understanding and diagnosing menstrually related migraine (Brandes JL, Freitag FG, Zacur HA) Advanced Studies in Medicine October 2005;5(9 A):S774-S782 SCOPUS ID: 2-s2.0-33644685129 10/01/2005 1 Citation

Characterization and prediction of emergency department use in chronic daily headache patients. (Freitag FG, Kozma CM, Slaton T, Osterhaus JT, Barron R) Headache 2005;45(7):891-8 PMID: 15985106 SCOPUS ID: 2-s2.0-22944445775 06/30/2005 20 Citations

Pain-free rates with zolmitriptan 2.5 mg ODT in the acute treatment of migraine: results of a large double-blind placebo- controlled trial. (Loder E, Freitag FG, Adelman J, Pearlmand S, Abu-Shakra S) Curr Med Res Opin 2005 Mar;21(3):381-9 PMID: 15811207 SCOPUS ID: 2-s2.0-16844372970 04/07/2005 35 Citations

As the "circle turns round" back to neurovascular basis in migraine (Freitag FG) Journal of the American Osteopathic Association April 2005;105(4 SUPPL. 2):S1 SCOPUS ID: 2-s2.0-33747464087 04/01/2005 2 Citations

Evidence-based review of patient-reported outcomes with botulinum toxin type A. (Jankovic J, Esquenazi A, Fehlings D, Freitag F, Lang AM, Naumann M) Clin Neuropharmacol 2004;27(5):234-44 PMID: 15602105 SCOPUS ID: 2-s2.0-7444247368 12/17/2004 40 Citations

LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. (Sang CN, Ramadan NM, Wallihan RG, Chappell AS, Freitag FG, Smith TR, Silberstein SD, Johnson KW, Phebus LA, Bleakman D, Ornstein PL, Arnold B, Tepper SJ, Vandenhende F) Cephalalgia 2004 Jul;24(7):596-602 PMID: 15196302 SCOPUS ID: 2-s2.0-2342483183 06/16/2004 152 Citations

Cluster headache. (Freitag FG) Prim Care 2004 Jun;31(2):313-29, vi PMID: 15172509 SCOPUS ID: 2-s2.0-2542490094 06/03/2004 8 Citations

Inpatient treatment of headache: an evidence-based assessment. (Freitag FG, Lake A 3rd, Lipton R, Cady R, Diamond S, Silberstein S, US Headache Guidelines Consortium, Section on Inpatient Treatment Chairpersons) Headache 2004 Apr;44(4):342-60 PMID: 15109359 SCOPUS ID: 2-s2.0-2142765287 04/28/2004 56 Citations

Divalproex in the treatment of migraine. (Freitag FG) Psychopharmacol Bull 2003;37 Suppl 2:98-115 PMID: 15021865 SCOPUS ID: 2-s2.0-3242745360 03/17/2004 22 Citations

Mood-Stabilizing Drugs and Cluster Headache Prophylaxis (Freitag FG) Headache and Pain Diagnostic Challenges Current Therapy November 2003;14(4):151-152 SCOPUS ID: 2-s2.0-0345356996 11/01/2003

Divalproex sodium extended-release for the prophylaxis of migraine headache. (Freitag FG) Expert Opin Pharmacother 2003 Sep;4(9):1573-8 PMID: 12943487 SCOPUS ID: 2-s2.0-0141740241 08/29/2003 8 Citations

Topiramate prophylaxis in patients suffering from migraine with aura: Results from a randomized, double-blind, placebo-controlled trial (Freitag FG) Advanced Studies in Medicine June 2003;3(6 C):S562-S564 SCOPUS ID: 2-s2.0-0037972893 06/01/2003 6 Citations

A Multifaceted Approach to the Patient with Refractory Headache (Diamond S, Freitag FG) Headache and Pain Diagnostic Challenges Current Therapy June 2003;14(2):81-86 SCOPUS ID: 2-s2.0-0345528135 06/01/2003

Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role? (Freitag FG) CNS Drugs 2003;17(6):373-81 PMID: 12696998 SCOPUS ID: 2-s2.0-0037540062 04/17/2003 37 Citations

Preventive treatment of migraine (Silberstein SD, Freitag FG) Neurology 8 April 2003;60(7 SUPPL. 2):S38-S44 SCOPUS ID: 2-s2.0-0037426375 04/08/2003 26 Citations

Migraine management (Freitag FG) Medical Crossfire 15 January 2003;5(1):23 SCOPUS ID: 2-s2.0-0037440247 01/15/2003

A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis. (Freitag FG, Collins SD, Carlson HA, Goldstein J, Saper J, Silberstein S, Mathew N, Winner PK, Deaton R, Sommerville K, Depakote ER Migraine Study Group) Neurology 2002 Jun 11;58(11):1652-9 PMID: 12058094 06/12/2002

A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis (Freitag FG, Collins SD, Carlson HA, Goldstein J, Saper J, Silberstein S, Mathew N, Winner PK, Deaton R, Sommerville K) Neurology 11 June 2002;58(11):1652-1659 SCOPUS ID: 2-s2.0-0037062572 06/11/2002 271 Citations

Acute treatment of migraine and the role of triptans. (Freitag FG) Curr Neurol Neurosci Rep 2001 Mar;1(2):125-32 PMID: 11898508 SCOPUS ID: 2-s2.0-0035296611 03/20/2002 9 Citations

Do over-the-counter medications help the physician manage migraine headache? (Freitag FG) Curr Pain Headache Rep 2002 Apr;6(2):156-61 PMID: 11872188 SCOPUS ID: 2-s2.0-0036547785 03/02/2002 1 Citation

Divalproex sodium in the treatment of migraine and cluster headaches. (Gallagher RM, Mueller LL, Freitag FG) J Am Osteopath Assoc 2002 Feb;102(2):92-4 PMID: 11866398 SCOPUS ID: 2-s2.0-0036167987 02/28/2002 56 Citations

Certifying the headache physician: A method of trans-specialty recognition of expertise (Freitag FG) Headache Quarterly 2002;13(1):9-10 SCOPUS ID: 2-s2.0-0036339551 01/01/2002

Preventative treatment of migraine headache with rofecoxib and montelukast (Freitag FG, Diamond S, Diamond ML, Urban GJ, Pepper BJ) Headache Quarterly 2001;12(4):237-239 SCOPUS ID: 2-s2.0-0035759224 12/01/2001 2 Citations

The use of ibuprofen plus caffeine to treat tension-type headache. (Diamond S, Freitag FG) Curr Pain Headache Rep 2001 Oct;5(5):472-8 PMID: 11560814 SCOPUS ID: 2-s2.0-0035491814 09/19/2001 22 Citations

Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. (Freitag FG, Cady R, DiSerio F, Elkind A, Gallagher RM, Goldstein J, Klapper JA, Rapoport AM, Sadowsky C, Saper JR, Smith TR) Headache 2001 Apr;41(4):391-8 PMID: 11318886 SCOPUS ID: 2-s2.0-0035028148 04/25/2001 44 Citations

Degradation kinetics of leucine5-enkephalin by plasma samples from healthy controls and various patient populations: in vitro drug effects. (Mosnaim AD, Wolf ME, Nguyen TD, Puente J, Freitag F, Diamond S) Am J Ther 2000 May;7(3):185-94 PMID: 11317167 SCOPUS ID: 2-s2.0-0034189812 04/24/2001 14 Citations

Potential of the Migraine Disability Assessment (MIDAS) Questionnaire as a public health initiative and in clinical practice. (Edmeads J, Láinez JM, Brandes JL, Schoenen J, Freitag F) Neurology 2001;56(6 Suppl 1):S29-34 PMID: 11294957 SCOPUS ID: 2-s2.0-0035086741 04/11/2001 49 Citations

Divalproex in the long-term treatment of chronic daily headache. (Freitag FG, Diamond S, Diamond ML, Urban GJ) Headache 2001 Mar;41(3):271-8 PMID: 11264687 SCOPUS ID: 2-s2.0-0035080026 03/27/2001 68 Citations

Topical lidocaine in migraine (Freitag F, Diamond S, Lockhart E) Clinical Pharmacology and Therapeutics 2001;69(2):P2 SCOPUS ID: 2-s2.0-33748978631 01/01/2001

Divalproex sodium in the preventative treatment of cluster headache (Freitag FG, Diamond S, Diamond ML, Urban GJ, Pepper BJ) Headache Quarterly 2001;12(2):113-116 SCOPUS ID: 2-s2.0-0034881082 01/01/2001

Tizanidine HCl in the preventive treatment of chronic tension-type headache (Freitag FG, Diamond S, Diamond ML, Urban GJ) Headache Quarterly 2000;11(4):283-285 SCOPUS ID: 2-s2.0-0034460962 12/01/2000

Intranasal civamide for the acute treatment of migraine headache. (Diamond S, Freitag F, Phillips SB, Bernstein JE, Saper JR) Cephalalgia 2000 Jul;20(6):597-602 PMID: 11075845 SCOPUS ID: 2-s2.0-0034455035 11/15/2000 77 Citations

Ibuprofen plus caffeine in the treatment of tension-type headache. (Diamond S, Balm TK, Freitag FG) Clin Pharmacol Ther 2000 Sep;68(3):312-9 PMID: 11014413 SCOPUS ID: 2-s2.0-0033834590 10/03/2000 102 Citations

Consortium publishes guidelines to lessen "headache" of treating migraine. (Freitag FG) J Am Osteopath Assoc 2000 Jun;100(6):348 PMID: 10902405 SCOPUS ID: 2-s2.0-0034198865 07/21/2000

The new treatments in migraine: First year clinical experience (Freitag FG, Diamond S, Diamond ML, Urban GJ, Pepper BJ) Headache Quarterly 2000;11(1):33-36 SCOPUS ID: 2-s2.0-0034113444 06/15/2000 4 Citations

Cluster headache, part 2: Variants (Diamond S, Freitag FG) Consultant 2000;40(3):451-455 SCOPUS ID: 2-s2.0-0034025383 04/11/2000

A multifaceted approach to the patient with refractory headache (Diamond S, Freitag FG) Consultant 2000;40(9):1640-1646 SCOPUS ID: 2-s2.0-0033838168 01/01/2000

An open use trial of tiagabine in migraine (Freitag FG, Diamond S, Diamond ML, Urban GJ, Pepper BJ) Headache Quarterly 2000;11(2):133-134 SCOPUS ID: 2-s2.0-0033847286 01/01/2000 5 Citations

Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports. (Diamond S, Pepper BJ, Diamond ML, Freitag FG, Urban GJ, Erdemoglu AK) Neurology 1998 Jul;51(1):274-6 PMID: 9674820 SCOPUS ID: 2-s2.0-0032109624 07/23/1998 18 Citations

Flow cytometric analysis of lymphocyte subsets in migraine patients during and outside of an acute headache attack. (Mosnaim AD, Kulaga H, Adams AJ, Wolf ME, Puente J, Freitag F, Diamond S) Cephalalgia 1998 May;18(4):197-201 PMID: 9642494 SCOPUS ID: 2-s2.0-0031843098 06/27/1998 23 Citations

IV histamine desensitization therapy in intractable cluster headache (Diamond S, Freitag FG, Diamond ML, Urban GJ) Headache Quarterly 1998;9(1):55-59 SCOPUS ID: 2-s2.0-0031892289 01/01/1998 6 Citations

Subcutaneous sumatriptan in patients treated with monoamine oxidase inhibitors and other prophylactic agents (Freitag FG, Diamond S, Diamond M, Urban G, Pepper B) Headache Quarterly 1998;9(2):165-171 SCOPUS ID: 2-s2.0-0031861566 01/01/1998 8 Citations

IV histamine in chronic cluster headaches (Freitag FG, Diamond S, Bambhvani S) Clinical Pharmacology and Therapeutics 1997;61(2):141 SCOPUS ID: 2-s2.0-33748962579 12/01/1997 2 Citations

Ibuprofen plus caffeine in the treatment of tension-type headache (Diamond S, Freitag FG, Balm TK, Berry DA) Clinical Pharmacology and Therapeutics 1997;61(2):194 SCOPUS ID: 2-s2.0-0344846669 12/01/1997 2 Citations

Open-label long-term use of divalproex sodium in headache (Diamond S, Freitag FG, Diamond ML, Urban GJ, Pepper BJ, Bhambhavani D) Headache Quarterly 1997;8(1):42-44 SCOPUS ID: 2-s2.0-0031052355 01/01/1997 4 Citations

Conducting clinical trials for the treatment of headache (Diamond S, Freitag FG) Headache Quarterly 1996;7(SUPPL. 2):6-13 SCOPUS ID: 2-s2.0-0030466460 12/01/1996

Panel discussion (Dalessio DJ, Feeney J, Freitag FG, Goldstein J) Headache Quarterly 1996;7(4 SUPPL.):21-30 SCOPUS ID: 2-s2.0-0030479704 12/01/1996

A double-blind placebo-controlled trial of nabumetone in the prophylaxis of migraine (Diamond S, Freitag FG, Diamond ML, Urban GJ, Pepper BJ) Headache Quarterly 1996;7(4):326-329 SCOPUS ID: 2-s2.0-0030479699 12/01/1996

Myths in migraine research: 1. Migraine and cluster headache patients are characterized by significant alterations in platelet monoamine oxidase activity (Mosnaim AD, Wolf ME, Curr M, Mosnaim JN, Freitag FG, Diamond S) Headache Quarterly 1996;7(3):225-234 SCOPUS ID: 2-s2.0-0029739015 09/22/1996 2 Citations

Subcutaneous dihydroergotamine mesylate (DHE) in the treatment of menstrual migraine (Diamond S, Freitag FG, Diamond ML, Urban GJ) Headache Quarterly 1996;7(2):145-147 SCOPUS ID: 2-s2.0-0030056701 08/02/1996 3 Citations

Experience with divalproex sodium as a new agent migraine prophylaxis (Klapper JA, Cady RK, Elkind AH, Freitag FG, Goldstein J) Headache Quarterly 1996;7(3 SUPPL.):20-23 SCOPUS ID: 2-s2.0-0029738308 01/01/1996

Apparent lack of correlation between tyramine and phenylethylamine content and the occurrence of food-precipitated migraine - Reexamination of a variety of food products frequently consumed in the United States and commonly restricted in tyramine-free diets (Mosnaim AD, Freitag FG, Ignacio R, Salas MA, Karoum F, Wolf ME, Diamond S) Headache Quarterly 1996;7(3):239-249 SCOPUS ID: 2-s2.0-0029757957 01/01/1996 9 Citations

Safety and efficacy of ergotamine tartrate and dihydroergotamine in the treatment of migraine and status migrainosus [RETIRED]. Working Panel of the Headache and Facial Pain Section of the American Academy of Neurology. (Silberstein SD, Young WB) Neurology 1995 Mar;45(3 Pt 1):577-84 PMID: 7898722 SCOPUS ID: 2-s2.0-0029078085 03/01/1995 78 Citations

Analysis of patients with cluster headache (Urban GJ, Diamond S, Freitag FG, Diamond ML) Headache Quarterly 1994;5(3):236-240 SCOPUS ID: 2-s2.0-0027998023 01/01/1994 6 Citations

In vitro studies of natural killer cell activity in migraineurs. Changes in response to a β-endorphin challenge during an acute migraine episode (Mosnaim AD, Wolf ME, Maturana P, Puente J, Freitag FG, Diamond S) Headache Quarterly 1994;5(2):142-148 SCOPUS ID: 2-s2.0-0028068743 01/01/1994 7 Citations

The acute treatment of migraine with transnasal butorphanol (TNB) (Freitag FG) Headache Quarterly 1993;4(SUPPL. 3):22-28 SCOPUS ID: 2-s2.0-0027859041 12/01/1993 2 Citations

A double blind trial of flunarizine in migraine prophylaxis (Diamond S, Freitag FG) Headache Quarterly 1993;4(2):169-172 SCOPUS ID: 2-s2.0-0027310534 01/01/1993 18 Citations

In vitro studies of natural killer cell activity in migraineurs. Changes in response to methionine-enkephalin challenge during an acute migraine episode (Mosnaim AD, Wolf ME, Maturana P, Puente J, Freitag FG, Diamond S) Headache Quarterly 1993;4(1):36-41 SCOPUS ID: 2-s2.0-0027532463 01/01/1993 6 Citations

Headache and facial pain. Part V: Migraine variants (Freitag FG) IM Internal Medicine 1992;13(1):31-52 SCOPUS ID: 2-s2.0-0027053944 12/01/1992

Neurobiologic mechanisms as an approach to the pharmacology of headache (Solomon GD, Mosnaim AD, Cohen M, Freitag FG, Russell IJ) Headache Quarterly 1992;3(3):309-318 SCOPUS ID: 2-s2.0-0026768133 01/01/1992

Platelet monoamine oxidase activity in cluster headache patients (Mosnaim AD, Huprikar S, Wolf ME, Callaghan OH, Freitag FG, Diamond S) Headache Quarterly 1992;3(2):172-176 SCOPUS ID: 2-s2.0-0026633372 01/01/1992 2 Citations

Emergency treatment of headache. (Freitag FG, Diamond M) Med Clin North Am 1991 May;75(3):749-61 PMID: 2020227 SCOPUS ID: 2-s2.0-0025845394 05/01/1991 11 Citations

A placebo controlled trial of flunarizine in migraine prophylaxis (Freitag FG, Diamond S, Diamond M) Cephalalgia 1991;11(SUPPL. 11):157-158 SCOPUS ID: 2-s2.0-0025824261 01/01/1991 12 Citations

Evaluation of headache patients by MRI (Prager JM, Rosenblum J, Mikulis DJ, Diamond S, Freitag FG) Headache Quarterly 1991;2(3):192-196 SCOPUS ID: 2-s2.0-0025742721 01/01/1991 8 Citations

The effects of weather on migraine frequency in Chicago (Diamond S, Freitag FG, Nursall A) Headache Quarterly 1990;1(2):136-145 SCOPUS ID: 2-s2.0-0025111539 01/01/1990 12 Citations

Ketoprofen in the prophylaxis of migraine (Diamond S, Freitag FG, Gallagher RM, Feinberg DT) Headache Quarterly 1990;1(1):75-77 SCOPUS ID: 2-s2.0-0025000466 01/01/1990 5 Citations

Plasma degradation of methionine-enkephalin by cluster headache patients. In vitro studies (Mosnaim AD, Wolf ME, Lee G, Puente J, Garmnerdsiri S, Freitag F, Diamond S) Headache Quarterly 1990;1(1):79-83 SCOPUS ID: 2-s2.0-0025089155 01/01/1990 6 Citations

Intravenous prochlorperazine for acute headache. JAMA 1989 Jul 28;262(4):501-2 PMID: 2739053 SCOPUS ID: 2-s2.0-0024403362 07/28/1989

Safety and effectiveness of cranial electrotherapy in the treatment of tension headache. (Solomon S, Elkind A, Freitag F, Gallagher RM, Moore K, Swerdlow B, Malkin S) Headache 1989 Jul;29(7):445-50 PMID: 2668227 SCOPUS ID: 2-s2.0-0024800443 07/01/1989 37 Citations

Endogenous opioid-like peptides in headache. An overview. (Mosnaim AD, Diamond S, Wolf ME, Puente J, Freitag FG) Headache 1989 Jun;29(6):368-72 PMID: 2668224 SCOPUS ID: 2-s2.0-0024813365 06/01/1989 20 Citations

Do non-steroidal anti-inflammatory agents have a role in the treatment of migraine headaches? (Diamond S, Freitag FG) Drugs 1989 Jun;37(6):755-60 PMID: 2667935 SCOPUS ID: 2-s2.0-0024674658 06/01/1989 17 Citations

The use of fluoxetine in the treatment of headache. (Diamond S, Freitag FG) Clin J Pain 1989 Jun;5(2):200-1 PMID: 2520405 SCOPUS ID: 2-s2.0-0024352350 06/01/1989 21 Citations

Treatment of headache. (Diamond S, Freitag FG) Clin J Pain 1989;5 Suppl 2:S7-16; discussion S16-8 PMID: 2520442 SCOPUS ID: 2-s2.0-0024792577 01/01/1989 3 Citations

Sexual headaches occurring in cluster headache patients. (Maliszewski M, Diamond S, Freitag FG) Clin J Pain 1989;5(1):45-7 PMID: 2520385 SCOPUS ID: 2-s2.0-0024596449 01/01/1989 9 Citations

Migraine headache variants. (Freitag FG) Clin J Pain 1989;5(1):11-7 PMID: 2520376 SCOPUS ID: 2-s2.0-0024602519 01/01/1989 1 Citation

The analgesic efficacy of transnasal butorphanol (TNB) in the acute treatment of migraine (Diamond S, Freitag FG, Gallagher RM, Chu G, Mosnaim AD) Cephalalgia 1989;9(SUPPL. 10):357 SCOPUS ID: 2-s2.0-0024950041 01/01/1989

Reversible multiple cranial nerve palsies in temporal (giant cell) arteritis with normal sedimentation rate: report of a case. (Freitag FG, Diamond S, Solomon GD) J Am Osteopath Assoc 1988 Mar;88(3):381-3 PMID: 3360641 SCOPUS ID: 2-s2.0-0023913270 03/01/1988 5 Citations

The mixed headache syndrome. A review (Diamond S, Freitag FG) Clinical Journal of Pain 1988;4(2):67-74 SCOPUS ID: 2-s2.0-0023753650 01/01/1988 1 Citation

I.v. verapamil and negative results. (Solomon GD, Freitag FG, Millstein E, Mehta N, Diamond S) Headache 1987 Jun;27(6):355 PMID: 3654194 SCOPUS ID: 2-s2.0-0023270259 06/01/1987

The role of MRI in the evaluation of a migraine population: preliminary data. (Kaplan RD, Solomon GD, Diamond S, Freitag FG) Headache 1987 Jun;27(6):315-8 PMID: 3654186 SCOPUS ID: 2-s2.0-0023265226 06/01/1987 10 Citations

Migraine headache. Working for the best outcome. (Diamond S, Freitag FG, Solomon GD, Millstein E) Postgrad Med 1987 Jun;81(8):174-6, 179-83 PMID: 3588460 SCOPUS ID: 2-s2.0-0023225832 06/01/1987 7 Citations

Plasma and platelet methionine-enkephalin levels in chronic cluster patients during an acute headache episode. (Mosnaim AD, Diamond S, Freitag F, Chevesich J, Wolf ME, Solomon G) Headache 1987 Jun;27(6):325-8 PMID: 3654188 SCOPUS ID: 2-s2.0-0023637929 06/01/1987 10 Citations

Fenoprofen in the prophylaxis of migraine: a double-blind, placebo controlled study. (Diamond S, Solomon GD, Freitag FG, Mehta ND) Headache 1987 May;27(5):246-9 PMID: 3298164 SCOPUS ID: 2-s2.0-0023502597 05/01/1987 14 Citations

Long-acting propranolol in the prophylaxis of migraine. (Diamond S, Solomon GD, Freitag FG, Mehta ND) Headache 1987 Feb;27(2):70-2 PMID: 3553068 SCOPUS ID: 2-s2.0-0023230193 02/01/1987 10 Citations

Selection of patients--critical aspects. (Diamond S, Solomon GD, Freitag FG, Mehta N) Neuroepidemiology 1987;6(4):172-7 PMID: 3317097 SCOPUS ID: 2-s2.0-0023216375 01/01/1987 3 Citations

Cluster headache (Diamond S, Solomon GD, Freitag FG) Clinical Journal of Pain 1987;3(3):171-176 SCOPUS ID: 2-s2.0-0023582147 01/01/1987 4 Citations

Plasma methionine enkephalin. Increased levels during a migraine episode. (Mosnaim AD, Chevesich J, Wolf ME, Freitag FG, Diamond S) Headache 1986 Jun;26(6):278-81 PMID: 3721864 SCOPUS ID: 2-s2.0-0022965359 06/01/1986 15 Citations

Inpatient treatment of headache: long-term results. (Diamond S, Freitag FG, Maliszewski M) Headache 1986 Apr;26(4):189-97 PMID: 3710772 SCOPUS ID: 2-s2.0-0023035905 04/01/1986 10 Citations

Diet and headache. Is there a link? (Diamond S, Prager J, Freitag FG) Postgrad Med 1986 Mar;79(4):279-86 PMID: 3952046 SCOPUS ID: 2-s2.0-0022551993 03/01/1986 16 Citations

Cold as an adjunctive therapy for headache. (Diamond S, Freitag FG) Postgrad Med 1986 Jan;79(1):305-9 PMID: 3941818 SCOPUS ID: 2-s2.0-0022574452 01/01/1986 22 Citations

Treatment of intractable cluster. (Diamond S, Freitag FG, Prager J, Gandhi S) Headache 1986 Jan;26(1):42-6 PMID: 3096911 SCOPUS ID: 2-s2.0-0022630328 01/01/1986 23 Citations

Olfactory aura in migraine. (Diamond S, Freitag FG, Prager J, Gandi S) N Engl J Med 1985 May 23;312(21):1390-1 PMID: 3990743 SCOPUS ID: 2-s2.0-0021957931 05/23/1985 26 Citations

Nadolol and placebo comparison study in the prophylactic treatment of migraine. (Freitag FG, Diamond S) J Am Osteopath Assoc 1984 Dec;84(4):343-7 PMID: 6150909 SCOPUS ID: 2-s2.0-0021709772 12/01/1984 35 Citations

Cluster headache with trigeminal neuralgia. An uncommon association that may be more than coincidental. (Diamond S, Freitag FG, Cohen JS) Postgrad Med 1984 Feb 01;75(2):165-72 PMID: 6420783 SCOPUS ID: 2-s2.0-0021327096 02/01/1984 20 Citations

Last update: 12/03/2020

© 2026 Clinical & Translational Science Institute
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53223

Publication and ontology data from NCBI | Disclaimer and Copyright

This site is a collaborative effort of the Medical College of Wisconsin and the Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number 2UL1TR001436) at the National Institutes of Health (NIH).

Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Frederick Freitag DO

Emeritus Professor

Publications (156)