Medical College of Wisconsin
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Guan Chen MD, PhD

Guan Chen MD, PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center


Research Experience

  • p38gamma MAPK, Cancer Signaling, Ras Oncogenesis, Nuclear Receptors, Targeted Cancer Therapy
  • Publications (59)

  • p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G) Cancer Res 2020 Aug 15;80(16):3251-3264 PMID: 32580961 SCOPUS ID: 2-s2.0-85089787021 06/26/2020    
  • p38gamma MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis (Fang Wang, Xiao-Mei Qi, Ryan Wertz, Matthew Mortensen, Catherine Hagen, John Evans, Yuri Sheinin, Michael James, Pengyuan Liu, Susan Tsai, James Thomas, Alexander Mackinnon, Michael Dwinell, Charles R Myers, Ramon Bartrons, Liwu Fu, Guan Chen) Cancer Research Wang F, Qi XM, Wertz R, et al. p38gamma MAPK is essential for aerobic glycolysis and pancreatic tumorigenesis [published online ahead of print, 2020 Jun 24]. Cancer Res. 2020;canres.3281.2019. doi:10.1158/0008-5472.CAN-19-3281 06/24/2020    
  • Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy. (Qi XM, Wang F, Mortensen M, Wertz R, Chen G) Acta Pharm Sin B 2018 Jul;8(4):511-517 PMID: 30109176 PMCID: PMC6089844 SCOPUS ID: 2-s2.0-85048878016 08/16/2018    
  • Editorial Preface for Targeted Cancer Therapy. (Chen G, Li W) Acta Pharm Sin B 2018 Jul;8(4):501-502 PMID: 30109174 PMCID: PMC6090083 08/16/2018    
  • Editorial Preface for Targeted Cancer Therapy (Chen G, Li W) Acta Pharmaceutica Sinica B July 2018;8(4):501-502 SCOPUS ID: 2-s2.0-85050349538 07/01/2018    
  • The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation. (Yin N, Lepp A, Ji Y, Mortensen M, Hou S, Qi XM, Myers CR, Chen G) J Biol Chem 2017 09 08;292(36):15070-15079 PMID: 28739874 PMCID: PMC5592682 SCOPUS ID: 2-s2.0-85029228747 07/26/2017       5 Citations
  • Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). (Ma S, Yin N, Qi X, Pfister SL, Zhang MJ, Ma R, Chen G) Oncotarget 2015 May 30;6(15):13320-33 PMID: 26079946 PMCID: PMC4537017 SCOPUS ID: 2-s2.0-84931073824 06/17/2015       10 Citations
  • p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. (Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G) Stem Cells 2015 Sep;33(9):2738-47 PMID: 26077647 PMCID: PMC4792188 SCOPUS ID: 2-s2.0-84940467357 06/17/2015       18 Citations
  • p38γ MAPK is required for inflammation-associated colon tumorigenesis. (Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K, Thomas JP, Myers CR, Stoner G, Chen G) Oncogene 2016 Feb 25;35(8):1039-48 PMID: 25961922 SCOPUS ID: 2-s2.0-84959509513 05/12/2015       16 Citations
  • Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer. (Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G) Oncotarget 2014 Jun 30;5(12):4269-82 PMID: 24962213 PMCID: PMC4147322 SCOPUS ID: 2-s2.0-84905098265 06/26/2014       11 Citations
  • Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537. (Suresh PS, Ma S, Migliaccio A, Chen G) Mol Cancer Ther 2014 Jan;13(1):230-8 PMID: 24227889 SCOPUS ID: 2-s2.0-84892585177 11/15/2013       14 Citations
  • MK2 Regulates Ras Oncogenesis through Stimulating ROS Production. (Kobayashi Y, Qi X, Chen G) Genes Cancer 2012 Jul;3(7-8):521-30 PMID: 23264852 PMCID: PMC3527985 12/25/2012    
  • p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. (Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G) J Biol Chem 2012 Aug 10;287(33):27895-905 PMID: 22730326 PMCID: PMC3431700 SCOPUS ID: 2-s2.0-84865009345 06/26/2012       15 Citations
  • p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription. (Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G) J Biol Chem 2012 Apr 27;287(18):14681-91 PMID: 22399296 PMCID: PMC3340246 SCOPUS ID: 2-s2.0-84860370781 03/09/2012       20 Citations
  • Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons. (Qi X, Hou S, Lepp A, Li R, Basir Z, Lou Z, Chen G) J Biol Chem 2011 Oct 14;286(41):35883-90 PMID: 21878638 PMCID: PMC3195563 SCOPUS ID: 2-s2.0-80053896975 09/01/2011       14 Citations
  • PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization. (Zhi HY, Hou SW, Li RS, Basir Z, Xiang Q, Szabo A, Chen G) Oncogene 2011 Apr 07;30(14):1706-15 PMID: 21119599 PMCID: PMC3072445 SCOPUS ID: 2-s2.0-79953789899 12/02/2010       28 Citations
  • PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. (Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G) Cancer Res 2010 Apr 01;70(7):2901-10 PMID: 20332238 PMCID: PMC2848905 SCOPUS ID: 2-s2.0-77950794747 03/25/2010       52 Citations
  • p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. (Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G) J Biol Chem 2010 May 14;285(20):15149-58 PMID: 20231272 PMCID: PMC2865276 SCOPUS ID: 2-s2.0-77952058710 03/17/2010       64 Citations
  • The p38 MAPK stress pathway as a tumor suppressor or more? (Loesch M, Chen G) Front Biosci 2008 May 01;13:3581-93 PMID: 18508457 PMCID: PMC4758212 05/30/2008       58 Citations
  • p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G) J Biol Chem 2007 Oct 26;282(43):31398-408 PMID: 17724032 SCOPUS ID: 2-s2.0-35748932065 08/29/2007       42 Citations
  • Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity. (Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G) J Biol Chem 2007 Jan 19;282(3):1544-51 PMID: 17121851 SCOPUS ID: 2-s2.0-33847265408 11/24/2006       22 Citations
  • p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. (Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G) Cancer Res 2006 Aug 01;66(15):7540-7 PMID: 16885352 PMCID: PMC2174269 SCOPUS ID: 2-s2.0-33747872178 08/04/2006       32 Citations
  • Essential role of p38gamma in K-Ras transformation independent of phosphorylation. (Tang J, Qi X, Mercola D, Han J, Chen G) J Biol Chem 2005 Jun 24;280(25):23910-7 PMID: 15851477 PMCID: PMC1224721 SCOPUS ID: 2-s2.0-21244490119 04/27/2005       47 Citations
  • p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. (Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G) J Biol Chem 2004 May 21;279(21):22138-44 PMID: 15037631 SCOPUS ID: 2-s2.0-2542458262 03/24/2004       52 Citations
  • Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. (Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G) J Biol Chem 2004 Feb 20;279(8):6769-77 PMID: 14638681 SCOPUS ID: 2-s2.0-1342325421 11/26/2003       26 Citations
  • p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. (Pramanik R, Qi X, Borowicz S, Choubey D, Schultz RM, Han J, Chen G) J Biol Chem 2003 Feb 14;278(7):4831-9 PMID: 12475989 SCOPUS ID: 2-s2.0-0038363324 12/12/2002       122 Citations
  • The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. (Qi X, Pramanik R, Wang J, Schultz RM, Maitra RK, Han J, DeLuca HF, Chen G) J Biol Chem 2002 Jul 19;277(29):25884-92 PMID: 11983707 SCOPUS ID: 2-s2.0-0037135524 05/02/2002       87 Citations
  • Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity. (Stacey DW, Hitomi M, Chen G) Mol Cell Biol 2000 Dec;20(24):9127-37 PMID: 11094065 PMCID: PMC102171 SCOPUS ID: 2-s2.0-0034461638 11/30/2000       29 Citations
  • The p38 pathway provides negative feedback for Ras proliferative signaling. (Chen G, Hitomi M, Han J, Stacey DW) J Biol Chem 2000 Dec 15;275(50):38973-80 PMID: 10978313 SCOPUS ID: 2-s2.0-0034671847 09/09/2000       142 Citations
  • Ras stimulates DNA topoisomerase II alpha through MEK: a link between oncogenic signaling and a therapeutic target. (Chen G, Templeton D, Suttle DP, Stacey DW) Oncogene 1999 Nov 25;18(50):7149-60 PMID: 10597316 SCOPUS ID: 2-s2.0-0033604451 12/22/1999       25 Citations
  • Dissociation of CDK2 from cyclin A in response to the topoisomerase II inhibitor etoposide in v-src-transformed but not normal NIH 3T3 cells. (Chen G, Hitomi M) Exp Cell Res 1999 Jun 15;249(2):327-36 PMID: 10366432 SCOPUS ID: 2-s2.0-0033563637 06/15/1999       7 Citations
  • Biochemical characterization of in vivo alkylating agent resistance of a murine EMT-6 mammary carcinoma. Implication for systemic involvement in the resistance phenotype. (Chen G, Teicher BA, Frei E 3rd) Cancer Biochem Biophys 1998 Jun;16(1-2):139-55 PMID: 9923973 SCOPUS ID: 2-s2.0-2442628298 01/29/1999       9 Citations
  • Protection against cyclophosphamide-induced alopecia and inhibition of mammary tumor growth by topical 1,25-dihydroxyvitamin D3 in mice. (Chen G, Baechle A, Nevins TD, Oh S, Harmon C, Stacey DW) Int J Cancer 1998 Jan 19;75(2):303-9 PMID: 9462723 SCOPUS ID: 2-s2.0-0032545725 02/14/1998       27 Citations
  • Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide. (Chen G, Shu J, Stacey DW) Oncogene 1997 Oct 02;15(14):1643-51 PMID: 9349497 SCOPUS ID: 2-s2.0-0030694260 02/12/1998       54 Citations
  • Antisense oligonucleotides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts. (Chen G, Oh S, Monia BP, Stacey DW) J Biol Chem 1996 Nov 08;271(45):28259-65 PMID: 8910444 SCOPUS ID: 2-s2.0-0029903628 11/08/1996       63 Citations
  • Differential interactions of Pgp inhibitor thaliblastine with adriamycin, etoposide, taxol and anthrapyrazole CI941 in sensitive and multidrug-resistant human MCF-7 breast cancer cells. (Chen G, Teicher BA, Frei E 3rd) Anticancer Res 1996 Nov-Dec;16(6B):3499-505 PMID: 9042212 SCOPUS ID: 2-s2.0-0030513617 11/01/1996       13 Citations
  • Transforming growth factor-beta in in vivo resistance. (Teicher BA, Holden SA, Ara G, Chen G) Cancer Chemother Pharmacol 1996;37(6):601-9 PMID: 8612316 SCOPUS ID: 2-s2.0-0029873924 01/01/1996       34 Citations
  • Positive correlation between cellular glutathione and acquired cisplatin resistance in human ovarian cancer cells. (Chen G, Hutter KJ, Zeller WJ) Cell Biol Toxicol 1995 Oct;11(5):273-81 PMID: 8608408 SCOPUS ID: 2-s2.0-0028860368 10/01/1995       25 Citations
  • Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance. (Chen G, Waxman DJ) J Pharmacol Exp Ther 1995 Sep;274(3):1271-7 PMID: 7562498 SCOPUS ID: 2-s2.0-0029151639 09/01/1995       17 Citations
  • Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism. (Chang TK, Chen G, Waxman DJ) J Pharmacol Exp Ther 1995 Jul;274(1):270-5 PMID: 7616408 SCOPUS ID: 2-s2.0-0029011523 07/01/1995       34 Citations
  • Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells. (Chen G, Waxman DJ) Biochem Pharmacol 1995 May 26;49(11):1691-701 PMID: 7786310 SCOPUS ID: 2-s2.0-0029076803 05/26/1995       45 Citations
  • Increased poly(ADP-ribose) formation in cisplatin-resistant rat ovarian tumor cells. (Chen G, Zeller WJ) Anticancer Res 1994 Jul-Aug;14(4A):1461-7 PMID: 7979172 SCOPUS ID: 2-s2.0-0028029995 07/01/1994       8 Citations
  • Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells. (Chen G, Waxman DJ) Biochem Pharmacol 1994 Mar 15;47(6):1079-87 PMID: 8147907 SCOPUS ID: 2-s2.0-0028279942 03/15/1994       70 Citations
  • Collateral sensitivity to thaliblastine and/or hyperthermia exhibited by a rat ovarian tumor cell line selected for resistance to cisplatin. (Chen G, Zeller WJ, Todorov DK) Anticancer Res 1993 Sep-Oct;13(5A):1269-75 PMID: 8239496 SCOPUS ID: 2-s2.0-0027331851 09/01/1993       9 Citations
  • Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein. (Chen G, Ramachandran C, Krishan A) Cancer Res 1993 Jun 01;53(11):2544-7 PMID: 8098661 SCOPUS ID: 2-s2.0-0027322989 06/01/1993       31 Citations
  • Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment. (Bürkle A, Chen G, Küpper JH, Grube K, Zeller WJ) Carcinogenesis 1993 Apr;14(4):559-61 PMID: 8472314 SCOPUS ID: 2-s2.0-0027223526 04/01/1993       95 Citations
  • Reversal of acquired cisplatin resistance by nicotinamide in vitro and in vivo. (Chen G, Zeller WJ) Cancer Chemother Pharmacol 1993;33(2):157-62 PMID: 8261576 SCOPUS ID: 2-s2.0-0027367451 01/01/1993       15 Citations
  • Effects of thaliblastine on cytotoxicity and DNA damage in drug-sensitive and -resistant rat ovarian tumor cells treated with cisplatin. (Chen G, Zeller WJ) Anticancer Res 1993 Jan-Feb;13(1):219-23 PMID: 8476216 SCOPUS ID: 2-s2.0-0027413154 01/01/1993       4 Citations
  • Multiple effects of 3-aminobenzamide on DNA damage induced by cisplatin (DDP) in DDP-sensitive and -resistant rat ovarian tumor cell lines. (Chen G, Zeller WJ) Cancer Lett 1992 Oct 30;67(1):27-33 PMID: 1423242 SCOPUS ID: 2-s2.0-0026545729 10/30/1992       10 Citations
  • Antitumor activity of thaliblastine (NSC-68075) in experimental ovarian tumor cell lines sensitive and resistant to cisplatin. (Chen G, Todorov DK, Zeller WJ) Cancer Lett 1992 Feb 29;62(2):173-7 PMID: 1531781 SCOPUS ID: 2-s2.0-0026590726 02/29/1992       12 Citations
  • Investigations on synergistic effects of BSO and 3AB for the reversal of cisplatin resistance (Chen G, Zeller WJ) Tumor Diagnostik und Therapie 1991;12(6):226-229 SCOPUS ID: 2-s2.0-0026315911 12/01/1991    
  • Augmentation of cisplatin (DDP) cytotoxicity in vivo by DL-buthionine sulfoximine (BSO) in DDP-sensitive and-resistant rat ovarian tumors and its relation to DNA interstrand cross links. (Chen G, Zeller WJ) Anticancer Res 1991 Nov-Dec;11(6):2231-7 PMID: 1776864 SCOPUS ID: 2-s2.0-0026315232 11/01/1991       26 Citations
  • Karyotypic change from heteroploidy to near diploidy associated with development of cisplatin resistance in a rat ovarian tumour cell line. (Chen G, Hutter KJ, Bullerdiek J, Zeller WJ) J Cancer Res Clin Oncol 1991;117(6):539-42 PMID: 1744159 SCOPUS ID: 2-s2.0-0025988894 01/01/1991       10 Citations
  • Chemoresistance in rat ovarian tumours. (Zeller WJ, Frühauf S, Chen G, Keppler BK, Frei E, Kaufmann M) Eur J Cancer 1991;27(1):62-7 PMID: 1826445 SCOPUS ID: 2-s2.0-0026080482 01/01/1991       24 Citations
  • In vitro investigations on induction and reversal of cisplatin resistance in a rat ovarian tumor cell line. (Chen G, Zeller WJ) J Cancer Res Clin Oncol 1990;116(5):443-7 PMID: 2121738 SCOPUS ID: 2-s2.0-0025077871 01/01/1990       22 Citations
  • Enhancement of cisplatin (DDP) antitumor activity by 3-aminobenzamide in rat ovarian tumors sensitive and resistant to DDP in vivo. (Chen G, Zeller WJ) Cancer Chemother Pharmacol 1990;26(1):37-41 PMID: 2322989 SCOPUS ID: 2-s2.0-0025373830 01/01/1990       20 Citations
  • Determination of intracellular reduced glutathione and glutathione related enzyme activities in cisplatin-sensitive and resistant experimental ovarian carcinoma cell lines. (Chen G, Frei E, Zeller WJ) Cancer Lett 1989 Aug;46(3):207-11 PMID: 2766260 SCOPUS ID: 2-s2.0-0024450999 08/01/1989       21 Citations
  • Biological activity of hydroxylated chloroethylnitrosoureas. (Zeller WJ, Frühauf S, Chen G, Eisenbrand G, Lijinsky W) Cancer Res 1989 Jun 15;49(12):3267-70 PMID: 2720679 SCOPUS ID: 2-s2.0-0024397144 06/15/1989       9 Citations
  • Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide. (Chen G, Pan QC) Cancer Chemother Pharmacol 1988;22(4):303-7 PMID: 2971467 SCOPUS ID: 2-s2.0-0023793075 01/01/1988       36 Citations
  • Last update: 09/16/2020
    jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a