Medical College of Wisconsin
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Guru Prasad Sharma

Guru Prasad Sharma profile photo picture

Research Scientist I

Institution: Medical College of Wisconsin
Department: Radiation Oncology

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0003-3197-4396


I am willing to collaborate on research projects.
I am willing to be a peer mentor.

View Curriculum Vitae

Research Areas of Interest

  • Acute Radiation Syndrome
  • Lung
  • Radiation Injuries
  • Rats

    • Research Experience

  • Animals
  • Endothelial Cells
  • Mice
  • Radiation Injuries
  • Rats

    • Publications (27)

  • Sex-specific differences in lung mitochondrial function and injury in rats exposed to hyperoxia. (Taheri P, Taye AG, Dave D, Jacobs ER, Sharma GP, Clough AV, Dash RK, Audi SH) J Appl Physiol (1985) 2026 May 01;140(5):1230-1250 PMID: 41934471 PMCID: PMC13142200 SCOPUS ID: 2-s2.0-105037506711 04/05/2026    
  • Lung uptake of two SPECT markers identifies sensitivity to hyperoxia-induced acute respiratory distress syndrome in rats. (Clough AV, Taheri P, Sharma GP, Zhao M, Jacobs ER, Audi SH) Front Physiol 2025;16:1648159 PMID: 41018018 PMCID: PMC12463966 SCOPUS ID: 2-s2.0-105017092807 09/29/2025       2 Citations
  • Activation of Angiotensin-Converting Enzyme 2 Mitigates Gastrointestinal Acute Radiation Syndrome. (Sharma GP, Nissen A, Gasperetti T, Foeckler J, Frei AC, Kuehn R, Gerhartz M, Heinzelman P, Romero PA, Zenga J, Himburg HA) Int J Radiat Oncol Biol Phys 2026 Feb 01;124(2):488-503 PMID: 40967372 PMCID: PMC12797870 SCOPUS ID: 2-s2.0-105019379840 09/19/2025       2 Citations
  • Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability. (Kosuru R, Romito O, Sharma GP, Ferraresso F, Ghadrdoost Nakhchi B, Yang K, Mammoto T, Mammoto A, Kastrup CJ, Zhang DX, Goldspink PH, Trebak M, Chrzanowska M) Arterioscler Thromb Vasc Biol 2024 Nov;44(11):2271-2287 PMID: 39324266 PMCID: PMC11495542 SCOPUS ID: 2-s2.0-85206451357 09/26/2024       16 Citations
  • Editorial: Ongoing advancements in the research of radiation- induced toxicity and the development of interventions to protect and/or mitigate its effects. (Cui W, Plett PA, Sharma GP, Kerns S, MacVittie TJ) Front Public Health 2024;12:1471228 PMID: 39234079 PMCID: PMC11372479 SCOPUS ID: 2-s2.0-85203343450 09/05/2024    
  • Type I interferon signaling promotes radioresistance in head and neck cancer. (Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA) Transl Cancer Res 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 SCOPUS ID: 2-s2.0-85195040296 06/17/2024       6 Citations
  • Mitochondrial function in lungs of rats with different susceptibilities to hyperoxia-induced acute lung injury. (Taheri P, Dave DD, Dash RK, Sharma GP, Clough AV, Jacobs ER, Audi SH) J Appl Physiol (1985) 2024 Aug 01;137(2):233-253 PMID: 38867668 PMCID: PMC11424179 SCOPUS ID: 2-s2.0-85200827997 06/13/2024       7 Citations
  • 2nd Window NIR Imaging of Radiation Injury Mitigation Provided by Reduced Notch-Dll4 Expression on Vasculature. (Kondelaji MHR, Sharma GP, Jagtap J, Shafiee S, Hansen C, Gasperetti T, Frei A, Veley D, Narayanan J, Fish BL, Parchur AK, Ibrahim EH, Medhora M, Himburg HA, Joshi A) Mol Imaging Biol 2024 Feb;26(1):124-137 PMID: 37530966 PMCID: PMC11188939 SCOPUS ID: 2-s2.0-85166543488 08/02/2023       7 Citations
  • X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer. (Sharma G, Razeghi Kondelaji MH, Sharma GP, Hansen C, Parchur AK, Shafiee S, Jagtap JM, Fish B, Bergom C, Paulson E, Hall WA, Himburg HA, Joshi A) Technol Cancer Res Treat 2023;22:15330338231189593 PMID: 37469184 PMCID: PMC10363893 SCOPUS ID: 2-s2.0-85165292958 07/20/2023       9 Citations
  • Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury. (Sharma GP, Frei A, Fish B, Gasperetti T, Veley D, Szalewski N, Nissen A, Himburg HA) Front Physiol 2023;14:1191237 PMID: 37275232 PMCID: PMC10235526 SCOPUS ID: 2-s2.0-85161056291 06/05/2023       14 Citations
  • Delayed renal injury in survivors of hematologic acute radiation syndrome. (Gasperetti T, Frei A, Prasad Sharma G, Pierce L, Veley D, Szalewski N, Munjal Mehta S, Fish BL, Pleimes D, Himburg HA) Int J Radiat Biol 2023;99(7):1130-1138 PMID: 36688956 PMCID: PMC10313734 SCOPUS ID: 2-s2.0-85147298374 01/24/2023       5 Citations
  • Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure. (Sharma GP, Himburg HA) Toxics 2022 Dec 01;10(12) PMID: 36548580 PMCID: PMC9781710 SCOPUS ID: 2-s2.0-85144737806 12/23/2022       11 Citations
  • Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression. (Sharma GP, Kosuru R, Lakshmikanthan S, Zheng S, Chen Y, Burns R, Xin G, Cui W, Chrzanowska M) Angiogenesis 2023 May;26(2):265-278 PMID: 36403190 SCOPUS ID: 2-s2.0-85142245350 11/21/2022       12 Citations
  • Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate. (Gasperetti T, Sharma GP, Frei AC, Pierce L, Veley D, Szalewski N, Narayanan J, Fish BL, Himburg HA) Radiat Res 2022 Oct 01;198(4):325-335 PMID: 35904437 PMCID: PMC9641750 SCOPUS ID: 2-s2.0-85139804264 07/30/2022       13 Citations
  • Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model. (Zenga J, Awan MJ, Frei A, Petrie E, Sharma GP, Shreenivas A, Shukla M, Himburg HA) Head Neck 2022 Jun;44(6):1324-1334 PMID: 35261119 PMCID: PMC9081149 SCOPUS ID: 2-s2.0-85125920861 03/10/2022       7 Citations
  • Pharmacologic ACE-Inhibition Mitigates Radiation-Induced Pneumonitis by Suppressing ACE-Expressing Lung Myeloid Cells. (Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, Himburg HA) Int J Radiat Oncol Biol Phys 2022 May 01;113(1):177-191 PMID: 35093482 PMCID: PMC9018504 SCOPUS ID: 2-s2.0-85125928392 01/31/2022       35 Citations
  • A revolutionary breakthrough of bionanomaterials in tissue engineering and regenerative medicine (Shankar P, Jagtap J, Sharma G, Sharma GP, Singh J, Parashar M, Kumar G, Mittal S, Sharma MK, Jadhav K, Parashar D) Bionanotechnology Emerging Applications of Bionanomaterials 1 January 2022:399-441 SCOPUS ID: 2-s2.0-85137443298 01/01/2022       7 Citations
  • Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells. (Sharma GP, Frei AC, Narayanan J, Gasperetti T, Veley D, Amjad A, Albano K, Fish BL, Himburg HA) PLoS One 2021;16(10):e0259042 PMID: 34695155 PMCID: PMC8544859 SCOPUS ID: 2-s2.0-85117930366 10/26/2021       15 Citations
  • Asymptomatic low-density Plasmodium infection during non-transmission season: a community-based cross-sectional study in two districts of North Eastern Region, India. (Shankar H, Phookan S, Singh MP, Bharti RS, Ahmed N, Yadav CP, Sharma GP, Singh K, Kaur H, Mishra N) Trans R Soc Trop Med Hyg 2021 Oct 01;115(10):1198-1206 PMID: 33580962 SCOPUS ID: 2-s2.0-85103353476 02/14/2021       12 Citations
  • Genomic analysis of a novel species Halomonas shambharensis isolated from hypersaline lake in Northwest India. (Jadhav K, Kushwaha B, Jadhav I, Shankar P, Geethadevi A, Kumar G, Mittal S, Sharma GP, Parashar M, Parashar D) Mol Biol Rep 2021 Feb;48(2):1045-1053 PMID: 33479827 SCOPUS ID: 2-s2.0-85099741349 01/23/2021       2 Citations
  • Redox interactome in malaria parasite Plasmodium falciparum. (Tiwari S, Sharma N, Sharma GP, Mishra N) Parasitol Res 2021 Feb;120(2):423-434 PMID: 33459846 SCOPUS ID: 2-s2.0-85100204639 01/19/2021       22 Citations
  • Whole-Genome Shotgun Sequence of Halomonas sp. Strain SBS 10, Isolated from a Hypersaline Lake in India. (Kushwaha B, Sharma GP, Sharma A, Shankar P, Geethadevi A, Sharma N, Sharma MK, Jadhav I, Parashar D, Jadhav K) Microbiol Resour Announc 2020 Jan 02;9(1) PMID: 31896639 PMCID: PMC6940291 SCOPUS ID: 2-s2.0-85077808388 01/04/2020       6 Citations
  • CID-6033590 inhibits p38MAPK pathway and induces S-phase cell cycle arrest and apoptosis in DU145 and PC-3 cells. (Sharma GP, Gurung SK, Inam A, Nigam L, Bist A, Mohapatra D, Senapati S, Subbarao N, Azam A, Mondal N) Toxicol In Vitro 2019 Oct;60:420-436 PMID: 31175925 SCOPUS ID: 2-s2.0-85068364782 06/09/2019       14 Citations
  • Design, synthesis and biological evaluation of quinazolin-4(3H)-one Schiff base conjugates as potential antiamoebic agents (Tariq S, Avecilla F, Sharma GP, Mondal N, Azam A) Journal of Saudi Chemical Society March 2018;22(3):306-315 SCOPUS ID: 2-s2.0-84995555322 03/01/2018       13 Citations
  • Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications. (Narayanaswamy N, Das S, Samanta PK, Banu K, Sharma GP, Mondal N, Dhar SK, Pati SK, Govindaraju T) Nucleic Acids Res 2015 Oct 15;43(18):8651-63 PMID: 26350219 PMCID: PMC4605319 SCOPUS ID: 2-s2.0-84961883530 09/10/2015       76 Citations
  • Novel insights into the regulation of malarial calcium-dependent protein kinase 1. (Ahmed A, Gaadhe K, Sharma GP, Kumar N, Neculai M, Hui R, Mohanty D, Sharma P) FASEB J 2012 Aug;26(8):3212-21 PMID: 22539638 PMCID: PMC3405269 SCOPUS ID: 2-s2.0-84864779342 04/28/2012       23 Citations
  • PfSRPK1, a novel splicing-related kinase from Plasmodium falciparum. (Dixit A, Singh PK, Sharma GP, Malhotra P, Sharma P) J Biol Chem 2010 Dec 03;285(49):38315-23 PMID: 20870716 PMCID: PMC2992265 SCOPUS ID: 2-s2.0-78649642686 09/28/2010       37 Citations
    • Last update: 05/17/2026