Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Heather A. Himburg PhD

Heather A. Himburg PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Radiation Oncology
Program: Teaching

Member of the Cancer Center
Member of the Cardiovascular Center


I am willing to collaborate on research projects.

View Curriculum Vitae

Publications (50)

  • IPW-5371 mitigates the delayed effects of acute radiation exposure in WAG/RijCmcr rats when started 15 days after PBI with bone marrow sparing. (Fish BL, Hart B, Gasperetti T, Narayanan J, Gao F, Veley D, Pierce L, Himburg HA, MacVittie T, Medhora M) Int J Radiat Biol 2023 Feb 15:1-11 PMID: 36794325 SCOPUS ID: 2-s2.0-85148532473 02/17/2023    
  • Cord Blood-Derived Endothelial Progenitor Cells Promote In Vivo Regeneration of Human Hematopoietic Bone Marrow. (Doan PL, Frei AC, Piryani SO, Szalewski N, Fan E, Himburg HA) Int J Radiat Oncol Biol Phys 2023 Feb 14 PMID: 36792018 02/16/2023    
  • Delayed renal injury in survivors of hematologic acute radiation syndrome. (Gasperetti T, Frei A, Prasad Sharma G, Pierce L, Veley D, Szalewski N, Munjal Mehta S, Fish BL, Pleimes D, Himburg HA) Int J Radiat Biol 2023 Jan 25:1-9 PMID: 36688956 SCOPUS ID: 2-s2.0-85147298374 01/24/2023    
  • Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation (Zenga J, Awan MJ, Frei A, Shukla M, Shreenivas A, Wong SJ, Himburg HA) Oral Oncology Reports 2022, 100010. ISSN 2772-9060, https://doi.org/10.1016/j.oor.2022.100010. 12/30/2022    
  • Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure. (Sharma GP, Himburg HA) Toxics 2022 Dec 01;10(12) PMID: 36548580 PMCID: PMC9781710 SCOPUS ID: 2-s2.0-85144737806 12/23/2022    
  • Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate. (Gasperetti T, Sharma GP, Frei AC, Pierce L, Veley D, Szalewski N, Narayanan J, Fish BL, Himburg HA) Radiat Res 2022 Oct 01;198(4):325-335 PMID: 35904437 PMCID: PMC9641750 SCOPUS ID: 2-s2.0-85139804264 07/30/2022       1 Citation
  • Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model. (Zenga J, Awan MJ, Frei A, Petrie E, Sharma GP, Shreenivas A, Shukla M, Himburg HA) Head Neck 2022 Jun;44(6):1324-1334 PMID: 35261119 PMCID: PMC9081149 SCOPUS ID: 2-s2.0-85125920861 03/10/2022    
  • Pharmacologic ACE-Inhibition Mitigates Radiation-Induced Pneumonitis by Suppressing ACE-Expressing Lung Myeloid Cells. (Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, Himburg HA) Int J Radiat Oncol Biol Phys 2022 May 01;113(1):177-191 PMID: 35093482 PMCID: PMC9018504 SCOPUS ID: 2-s2.0-85125928392 01/31/2022       5 Citations
  • Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution. (Termini CM, Pang A, Fang T, Roos M, Chang VY, Zhang Y, Setiawan NJ, Signaevskaia L, Li M, Kim MM, Tabibi O, Lin PK, Sasine JP, Chatterjee A, Murali R, Himburg HA, Chute JP) Nat Commun 2021 Nov 30;12(1):6990 PMID: 34848712 PMCID: PMC8635308 SCOPUS ID: 2-s2.0-85120176028 12/02/2021       6 Citations
  • Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells. (Sharma GP, Frei AC, Narayanan J, Gasperetti T, Veley D, Amjad A, Albano K, Fish BL, Himburg HA) PLoS One 2021;16(10):e0259042 PMID: 34695155 PMCID: PMC8544859 SCOPUS ID: 2-s2.0-85117930366 10/26/2021       3 Citations
  • Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. (Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M) Health Phys 2021 Oct 01;121(4):419-433 PMID: 34546222 PMCID: PMC8577554 SCOPUS ID: 2-s2.0-85117425987 09/22/2021       7 Citations
  • Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration. (Fang T, Zhang Y, Chang VY, Roos M, Termini CM, Signaevskaia L, Quarmyne M, Lin PK, Pang A, Kan J, Yan X, Javier A, Pohl K, Zhao L, Scott P, Himburg HA, Chute JP) Blood 2020 Jul 23;136(4):441-454 PMID: 32369572 PMCID: PMC7378456 SCOPUS ID: 2-s2.0-85088499146 05/06/2020       7 Citations
  • Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. (Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP) J Clin Invest 2020 Jan 02;130(1):315-328 PMID: 31613796 PMCID: PMC6934217 SCOPUS ID: 2-s2.0-85077404546 10/16/2019       9 Citations
  • PTPσ inhibitors promote hematopoietic stem cell regeneration. (Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP) Nat Commun 2019 Aug 14;10(1):3667 PMID: 31413255 PMCID: PMC6694155 SCOPUS ID: 2-s2.0-85070740613 08/16/2019       17 Citations
  • Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells. (Kim MM, Schlussel L, Zhao L, Himburg HA) Radiat Res 2019 Jul;192(1):53-62 PMID: 31081743 PMCID: PMC6668624 SCOPUS ID: 2-s2.0-85068359875 05/14/2019       7 Citations
  • Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration. (Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP) Cell Stem Cell 2018 Sep 06;23(3):370-381.e5 PMID: 30100167 PMCID: PMC6482945 SCOPUS ID: 2-s2.0-85056484773 08/14/2018       70 Citations
  • Wild-type Kras expands and exhausts hematopoietic stem cells. (Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP) JCI Insight 2018 Jun 07;3(11) PMID: 29875320 PMCID: PMC6124423 SCOPUS ID: 2-s2.0-85056627323 06/08/2018       11 Citations
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. (Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP) Nat Med 2017 Jan;23(1):91-99 PMID: 27918563 PMCID: PMC5592969 SCOPUS ID: 2-s2.0-85001889482 12/06/2016       51 Citations
  • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. (Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP) Cell Rep 2016 Nov 01;17(6):1584-1594 PMID: 27806297 PMCID: PMC5963255 SCOPUS ID: 2-s2.0-84995621461 11/03/2016       19 Citations
  • Discussion: "Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties" (Rowland, E. M., Mohamied, Y., Chooi, K. Y., Bailey, E. L., and Weinberg, P. D., 2015, ASME J. Biomech. Eng., 137(10), p. 101003): An Alternative Approach Using Segmentation Based on Local Hemodynamics. (Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Friedman MH) J Biomech Eng 2016 Sep 01;138(9):0955011-2 PMID: 27437909 PMCID: PMC4993249 SCOPUS ID: 2-s2.0-85009400030 07/21/2016    
  • A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. (Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP) Radiat Res 2016 Aug;186(2):141-52 PMID: 27387861 PMCID: PMC6016841 SCOPUS ID: 2-s2.0-84982263977 07/09/2016       22 Citations
  • Ionizing Radiation: Toxicologic Action (Himburg HA, Chute JP) Mammalian Toxicology 27 March 2015:309-321 SCOPUS ID: 2-s2.0-84976562539 03/27/2015    
  • Mammalian Toxicology Chapter 15: Ionizing Radiation: Toxicologic Action (Himburg HA, Chute JP Editor: Abou‐Donia Mohamed B.) 02/27/2015    
  • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. (Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM) Gut 2016 Apr;65(4):683-92 PMID: 25596181 PMCID: PMC4504836 SCOPUS ID: 2-s2.0-84929919170 01/18/2015       21 Citations
  • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. (Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP) J Clin Invest 2015 Jan;125(1):177-82 PMID: 25415437 PMCID: PMC4382260 SCOPUS ID: 2-s2.0-84920461717 11/22/2014       20 Citations
  • A translatable predictor of human radiation exposure. (Lucas J, Dressman HK, Suchindran S, Nakamura M, Chao NJ, Himburg H, Minor K, Phillips G, Ross J, Abedi M, Terbrueggen R, Chute JP) PLoS One 2014;9(9):e107897 PMID: 25255453 PMCID: PMC4177872 SCOPUS ID: 2-s2.0-84907588604 09/26/2014       37 Citations
  • Pleiotrophin mediates hematopoietic regeneration via activation of RAS. (Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP) J Clin Invest 2014 Nov;124(11):4753-8 PMID: 25250571 PMCID: PMC4347246 SCOPUS ID: 2-s2.0-84908636760 09/25/2014       37 Citations
  • Imatinib tackles lymphoma via the PDGFRβ+ pericyte. (Chute JP, Himburg HA) Blood 2013 Jun 27;121(26):5107-8 PMID: 23813934 SCOPUS ID: 2-s2.0-84884171117 07/03/2013       8 Citations
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. (Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP) Nat Med 2013 Mar;19(3):295-304 PMID: 23377280 PMCID: PMC3594347 SCOPUS ID: 2-s2.0-84875228640 02/05/2013       133 Citations
  • Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche (Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP) Cell Reports 27 December 2012;2(6):1774 SCOPUS ID: 2-s2.0-84871699237 12/27/2012       31 Citations
  • Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. (Doan PL, Russell JL, Himburg HA, Helms K, Harris JR, Lucas J, Holshausen KC, Meadows SK, Daher P, Jeffords LB, Chao NJ, Kirsch DG, Chute JP) Stem Cells 2013 Feb;31(2):327-37 PMID: 23132593 PMCID: PMC3580267 SCOPUS ID: 2-s2.0-84874327921 11/08/2012       56 Citations
  • Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. (Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP) Cell Rep 2012 Oct 25;2(4):964-75 PMID: 23084748 PMCID: PMC3696585 SCOPUS ID: 2-s2.0-84868107930 10/23/2012       68 Citations
  • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. (Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP) PLoS One 2010 Jul 12;5(7):e11535 PMID: 20634956 PMCID: PMC2902517 SCOPUS ID: 2-s2.0-77955375162 07/17/2010       44 Citations
  • Endothelial gene expression in regions of defined shear exposure in the porcine iliac arteries. (LaMack JA, Himburg HA, Zhang J, Friedman MH) Ann Biomed Eng 2010 Jul;38(7):2252-62 PMID: 20387120 SCOPUS ID: 2-s2.0-77954659301 04/14/2010       9 Citations
  • Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. (Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP) Nat Med 2010 Apr;16(4):475-82 PMID: 20305662 PMCID: PMC3689427 SCOPUS ID: 2-s2.0-77950543499 03/23/2010       220 Citations
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. (Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP) Stem Cells 2010 Mar 31;28(3):523-34 PMID: 20054864 PMCID: PMC3909217 SCOPUS ID: 2-s2.0-77950589175 01/08/2010       55 Citations
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. (Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP) Blood 2009 Feb 26;113(9):2104-7 PMID: 19141867 PMCID: PMC2651019 SCOPUS ID: 2-s2.0-61849092556 01/15/2009       120 Citations
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. (Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP) Mol Endocrinol 2009 Feb;23(2):188-201 PMID: 19106195 PMCID: PMC2646618 SCOPUS ID: 2-s2.0-58849113213 12/25/2008       20 Citations
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. (Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP) PLoS One 2008 Apr 02;3(4):e1912 PMID: 18382685 PMCID: PMC2271127 SCOPUS ID: 2-s2.0-44849110695 04/03/2008       92 Citations
  • Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aorta. (LaMack JA, Himburg HA, Friedman MH) Atherosclerosis 2007 Dec;195(2):e35-41 PMID: 17588585 PMCID: PMC2683674 SCOPUS ID: 2-s2.0-36049003109 06/26/2007       11 Citations
  • Frequency-dependent response of the vascular endothelium to pulsatile shear stress. (Himburg HA, Dowd SE, Friedman MH) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H645-53 PMID: 17322417 SCOPUS ID: 2-s2.0-34547148984 02/27/2007       102 Citations
  • Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. (Friedman MH, Himburg HA, LaMack JA) J Biomech Eng 2006 Dec;128(6):965-8 PMID: 17154699 SCOPUS ID: 2-s2.0-33846424238 12/13/2006       6 Citations
  • Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. (Himburg HA, Friedman MH) J Biomech Eng 2006 Dec;128(6):852-6 PMID: 17154685 SCOPUS ID: 2-s2.0-33846443970 12/13/2006       31 Citations
  • Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. (Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ) Blood 2007 Mar 15;109(6):2365-72 PMID: 17095624 PMCID: PMC1852197 SCOPUS ID: 2-s2.0-33947265398 11/11/2006       76 Citations
  • The effect of waveform frequency and amplitude on vascular endothelial gene expresssion (Himburg HA, Friedman MH) Proceedings of the 2005 Summer Bioengineering Conference 2005;2005:327-328 SCOPUS ID: 2-s2.0-33646570860 12/01/2005    
  • A CFD-based method to evaluate the effect of shear stress on endothelial gene expression in vivo (Himburg HA, Lamack JA, Friedman MH) Proceedings of the 2005 Summer Bioengineering Conference 2005;2005:1392-1393 SCOPUS ID: 2-s2.0-33646546929 12/01/2005    
  • Effect of hypercholesterolemia on transendothelial EBD-albumin permeability and lipid accumulation in porcine iliac arteries. (Lamack JA, Himburg HA, Friedman MH) Atherosclerosis 2006 Feb;184(2):255-63 PMID: 15935354 SCOPUS ID: 2-s2.0-30044439227 06/07/2005       10 Citations
  • Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability. (LaMack JA, Himburg HA, Li XM, Friedman MH) Ann Biomed Eng 2005 Apr;33(4):457-64 PMID: 15909651 SCOPUS ID: 2-s2.0-18244382054 05/25/2005       38 Citations
  • Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. (Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Li XM, Friedman MH) Am J Physiol Heart Circ Physiol 2004 May;286(5):H1916-22 PMID: 14715506 SCOPUS ID: 2-s2.0-1942533437 01/13/2004       383 Citations
  • Model-based shear stress gradient in realistic vascular flows and its relation to arterial macromolecular permeability (LaMack JA, Himburg HA, Li XM, Friedman MH) American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 2003;55:89-90 SCOPUS ID: 2-s2.0-1842457052 01/01/2003    
    • Last update: 03/20/2023