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Heather A. Himburg PhD

Heather A. Himburg PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Radiation Oncology
Program: Teaching

Member of the Cancer Center
Member of the Cardiovascular Center


I am willing to collaborate on research projects.


Publications (34)

  • Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration. (Fang T, Zhang Y, Chang VY, Roos M, Termini CM, Signaevskaia L, Quarmyne M, Lin PK, Pang A, Kan J, Yan X, Javier A, Pohl K, Zhao L, Scott P, Himburg HA, Chute JP) Blood 2020 Jul 23;136(4):441-454 PMID: 32369572 PMCID: PMC7378456 05/06/2020    
  • Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling. (Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP) J Clin Invest 2020 01 02;130(1):315-328 PMID: 31613796 PMCID: PMC6934217 10/16/2019       2 Citations
  • PTPσ inhibitors promote hematopoietic stem cell regeneration. (Zhang Y, Roos M, Himburg H, Termini CM, Quarmyne M, Li M, Zhao L, Kan J, Fang T, Yan X, Pohl K, Diers E, Jin Gim H, Damoiseaux R, Whitelegge J, McBride W, Jung ME, Chute JP) Nat Commun 2019 08 14;10(1):3667 PMID: 31413255 PMCID: PMC6694155 08/16/2019       2 Citations
  • Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells. (Kim MM, Schlussel L, Zhao L, Himburg HA) Radiat Res 2019 07;192(1):53-62 PMID: 31081743 PMCID: PMC6668624 05/14/2019    
  • Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration. (Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP) Cell Stem Cell 2018 09 06;23(3):370-381.e5 PMID: 30100167 PMCID: PMC6482945 08/14/2018       22 Citations
  • Wild-type Kras expands and exhausts hematopoietic stem cells. (Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP) JCI Insight 2018 06 07;3(11) PMID: 29875320 PMCID: PMC6124423 06/08/2018       4 Citations
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. (Himburg HA, Doan PL, Quarmyne M, Yan X, Sasine J, Zhao L, Hancock GV, Kan J, Pohl KA, Tran E, Chao NJ, Harris JR, Chute JP) Nat Med 2017 01;23(1):91-99 PMID: 27918563 PMCID: PMC5592969 12/06/2016       29 Citations
  • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. (Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP) Cell Rep 2016 11 01;17(6):1584-1594 PMID: 27806297 PMCID: PMC5963255 11/03/2016       13 Citations
  • Discussion: "Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties" (Rowland, E. M., Mohamied, Y., Chooi, K. Y., Bailey, E. L., and Weinberg, P. D., 2015, ASME J. Biomech. Eng., 137(10), p. 101003): An Alternative Approach Using Segmentation Based on Local Hemodynamics. (Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Friedman MH) J Biomech Eng 2016 09 01;138(9) PMID: 27437909 PMCID: PMC4993249 07/21/2016    
  • A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. (Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP) Radiat Res 2016 08;186(2):141-52 PMID: 27387861 PMCID: PMC6016841 07/09/2016       7 Citations
  • Mammalian Toxicology Chapter 15: Ionizing Radiation: Toxicologic Action (Himburg HA, Chute JP Editor: Abou‐Donia Mohamed B.) 02/27/2015    
  • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. (Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM) Gut 2016 Apr;65(4):683-92 PMID: 25596181 PMCID: PMC4504836 01/18/2015       15 Citations
  • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. (Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP) J Clin Invest 2015 Jan;125(1):177-82 PMID: 25415437 PMCID: PMC4382260 11/22/2014       13 Citations
  • A translatable predictor of human radiation exposure. (Lucas J, Dressman HK, Suchindran S, Nakamura M, Chao NJ, Himburg H, Minor K, Phillips G, Ross J, Abedi M, Terbrueggen R, Chute JP) PLoS One 2014;9(9):e107897 PMID: 25255453 PMCID: PMC4177872 09/26/2014       27 Citations
  • Pleiotrophin mediates hematopoietic regeneration via activation of RAS. (Himburg HA, Yan X, Doan PL, Quarmyne M, Micewicz E, McBride W, Chao NJ, Slamon DJ, Chute JP) J Clin Invest 2014 Nov;124(11):4753-8 PMID: 25250571 PMCID: PMC4347246 09/25/2014       28 Citations
  • Imatinib tackles lymphoma via the PDGFRβ+ pericyte. (Chute JP, Himburg HA) Blood 2013 Jun 27;121(26):5107-8 PMID: 23813934 07/03/2013       6 Citations
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. (Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP) Nat Med 2013 Mar;19(3):295-304 PMID: 23377280 PMCID: PMC3594347 02/05/2013       104 Citations
  • Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. (Doan PL, Russell JL, Himburg HA, Helms K, Harris JR, Lucas J, Holshausen KC, Meadows SK, Daher P, Jeffords LB, Chao NJ, Kirsch DG, Chute JP) Stem Cells 2013 Feb;31(2):327-37 PMID: 23132593 PMCID: PMC3580267 11/08/2012       44 Citations
  • Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. (Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP) Cell Rep 2012 Oct 25;2(4):964-75 PMID: 23084748 PMCID: PMC3696585 10/23/2012       46 Citations
  • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. (Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP) PLoS One 2010 Jul 12;5(7):e11535 PMID: 20634956 PMCID: PMC2902517 07/17/2010       35 Citations
  • Endothelial gene expression in regions of defined shear exposure in the porcine iliac arteries. (LaMack JA, Himburg HA, Zhang J, Friedman MH) Ann Biomed Eng 2010 Jul;38(7):2252-62 PMID: 20387120 04/14/2010       9 Citations
  • Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. (Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP) Nat Med 2010 Apr;16(4):475-82 PMID: 20305662 PMCID: PMC3689427 03/23/2010       185 Citations
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. (Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP) Stem Cells 2010 Mar 31;28(3):523-34 PMID: 20054864 PMCID: PMC3909217 01/08/2010       51 Citations
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. (Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP) Blood 2009 Feb 26;113(9):2104-7 PMID: 19141867 PMCID: PMC2651019 01/15/2009       104 Citations
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. (Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP) Mol Endocrinol 2009 Feb;23(2):188-201 PMID: 19106195 PMCID: PMC2646618 12/25/2008       17 Citations
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. (Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP) PLoS One 2008 Apr 02;3(4):e1912 PMID: 18382685 PMCID: PMC2271127 04/03/2008       76 Citations
  • Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aorta. (LaMack JA, Himburg HA, Friedman MH) Atherosclerosis 2007 Dec;195(2):e35-41 PMID: 17588585 PMCID: PMC2683674 06/26/2007       11 Citations
  • Frequency-dependent response of the vascular endothelium to pulsatile shear stress. (Himburg HA, Dowd SE, Friedman MH) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H645-53 PMID: 17322417 02/27/2007       88 Citations
  • Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. (Friedman MH, Himburg HA, LaMack JA) J Biomech Eng 2006 Dec;128(6):965-8 PMID: 17154699 12/13/2006       6 Citations
  • Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. (Himburg HA, Friedman MH) J Biomech Eng 2006 Dec;128(6):852-6 PMID: 17154685 12/13/2006       28 Citations
  • Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. (Chute JP, Muramoto GG, Salter AB, Meadows SK, Rickman DW, Chen B, Himburg HA, Chao NJ) Blood 2007 Mar 15;109(6):2365-72 PMID: 17095624 PMCID: PMC1852197 11/11/2006       64 Citations
  • Effect of hypercholesterolemia on transendothelial EBD-albumin permeability and lipid accumulation in porcine iliac arteries. (Lamack JA, Himburg HA, Friedman MH) Atherosclerosis 2006 Feb;184(2):255-63 PMID: 15935354 06/07/2005       9 Citations
  • Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability. (LaMack JA, Himburg HA, Li XM, Friedman MH) Ann Biomed Eng 2005 Apr;33(4):457-64 PMID: 15909651 05/25/2005       35 Citations
  • Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. (Himburg HA, Grzybowski DM, Hazel AL, LaMack JA, Li XM, Friedman MH) Am J Physiol Heart Circ Physiol 2004 May;286(5):H1916-22 PMID: 14715506 01/13/2004       292 Citations
  • Last update: 10/27/2020
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