Medical College of Wisconsin
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Hongxu Xian PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Research Areas of Interest

  • Autophagy
  • Autophagy-Related Protein 7
  • CD4 Lymphocyte Count
  • DNA, Mitochondrial
  • Dendritic Cells
  • Inflammation
  • Inflammation Mediators
  • Macrophages
  • Mitochondria
  • Neurogenic Inflammation
  • immunology

    • Publications (12)

  • Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. (Antonucci L, Li N, Duran A, Cobo I, Nicoletti C, Watari K, Nandi SP, Zhu F, Zhao Y, Riahi I, Tsuda M, Shah VM, Morgan T, Waugh T, Caputo L, Liu Y, Rundberg Nilsson A, Xian H, Todoric J, Gu L, Sanchez-Lopez E, Eibl G, Vucic EA, Krawczyk M, Xu Q, Lowy AM, Hatzivassiliou G, Roose-Girma M, Skowronska-Krawczyk D, Scott DA, Bar-Sagi D, Tamayo P, Wu Y, Sears RC, Glass CK, Alexandrov LB, Puri PL, Dawson DW, Hu Y, Diaz-Meco MT, Moscat J, Karin M) Nat Cancer 2025 Jul;6(7):1263-1282 PMID: 40588523 PMCID: PMC12331375 SCOPUS ID: 2-s2.0-105009473074 07/01/2025    
  • Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation. (Xian H, Watari K, Ohira M, Brito JS, He P, Onyuru J, Zuniga EI, Hoffman HM, Karin M) Nat Immunol 2025 Jul;26(7):1168-1181 PMID: 40528028 SCOPUS ID: 2-s2.0-105008250331 06/18/2025       3 Citations
  • Death-Associated Protein 3 Triggers Intrinsic Apoptosis via Miro1 Upon Inducing Intracellular Calcium Changes. (Hu D, Yang Q, Xian H, Wang M, Zheng H, Mallilankaraman KB, Yu VC, Liou YC) MedComm (2020) 2025 May;6(5):e70214 PMID: 40351389 PMCID: PMC12064944 SCOPUS ID: 2-s2.0-105004823052 05/12/2025    
  • IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance. (Rundberg Nilsson A, Xian H, Shalapour S, Cammenga J, Karin M) bioRxiv 2023 Mar 02 PMID: 36747722 PMCID: PMC9900858 02/08/2023    
  • Oxidized mitochondrial DNA: a protective signal gone awry. (Xian H, Karin M) Trends Immunol 2023 Mar;44(3):188-200 PMID: 36739208 PMCID: PMC12045651 SCOPUS ID: 2-s2.0-85148755055 02/05/2023       47 Citations
  • Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. (Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M) Immunity 2022 Aug 09;55(8):1370-1385.e8 PMID: 35835107 PMCID: PMC9378606 SCOPUS ID: 2-s2.0-85135950950 07/15/2022       467 Citations
  • Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. (Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E) Immunity 2021 Jul 13;54(7):1463-1477.e11 PMID: 34115964 PMCID: PMC8189765 SCOPUS ID: 2-s2.0-85107723500 06/12/2021       312 Citations
  • Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy. (Xian H, Liou YC) Cell Death Differ 2021 Mar;28(3):827-842 PMID: 33208889 PMCID: PMC7937681 SCOPUS ID: 2-s2.0-85096233896 11/20/2020       113 Citations
  • STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism. (Xian H, Yang Q, Xiao L, Shen HM, Liou YC) Nat Commun 2019 May 03;10(1):2059 PMID: 31053718 PMCID: PMC6499814 SCOPUS ID: 2-s2.0-85065203621 05/06/2019       109 Citations
  • Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy. (Xian H, Liou YC) Autophagy 2019 Dec;15(12):2107-2125 PMID: 30894073 PMCID: PMC6844504 SCOPUS ID: 2-s2.0-85063580396 03/22/2019       52 Citations
  • Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. (Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC) J Biol Chem 2017 Oct 06;292(40):16697-16708 PMID: 28848050 PMCID: PMC5633131 SCOPUS ID: 2-s2.0-85030765773 08/30/2017       197 Citations
  • Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics. (Xiao L, Xian H, Lee KY, Xiao B, Wang H, Yu F, Shen HM, Liou YC) J Biol Chem 2015 Oct 09;290(41):24961-74 PMID: 26306039 PMCID: PMC4599003 SCOPUS ID: 2-s2.0-84943802980 08/26/2015       34 Citations
    • Last update: 11/01/2025