Medical College of Wisconsin
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Hui-Zi Chen PhD, MD

Hui-Zi Chen PhD, MD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Medicine Hematology Oncology

Member of the Cancer Center

View Curriculum Vitae

Publications (37)

  • EZH2 Inhibition Reshapes 3D Chromatin Architecture to Induce Immunogenic Phenotype in Small Cell Lung Cancer. (Parveen S, Adhinaveni R, Fang K, Choppavarapu L, Du M, Leone G, de Sarkar N, Jin V, Chen HZ) bioRxiv 2026 Jan 28 PMID: 41659399 PMCID: PMC12874048 02/09/2026    
  • CHIMERA-DDR: A Machine Learning Framework for Classifying Heterogeneous Mismatch-Repair and Homologous-Recombination Deficiency Patterns in Prostate Cancer. (Sharma K, Wilson DA, Wang Y, Haider S, Bhatlapenumarthi V, Boiarsky D, Cipriaso JM, Yermakov L, Dutta R, Vashisth M, Coleman IM, Bankhead A, Jadhav SK, Neupane B, Taylor BW, Morrissey C, Schweitzer MT, Montgomery RB, Rao S, Nevalainen MT, Nelson AA, Antonarakis ES, Pilié PG, Berchuk JE, Zarrabi KK, Pritchard CC, Kthari A, Chen HZ, George B, Kurzrock R, Ha G, Nelson PS, Auer PL, Banerjee A, Kilari D, De Sarkar N) bioRxiv 2025 Oct 14 PMID: 41278905 PMCID: PMC12633065 11/24/2025    
  • Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy. (Mountzios G, Sun L, Cho BC, Demirci U, Baka S, Gümüş M, Lugini A, Zhu B, Yu Y, Korantzis I, Han JY, Ciuleanu TE, Ahn MJ, Rocha P, Mazières J, Lau SCM, Schuler M, Blackhall F, Yoshida T, Owonikoko TK, Paz-Ares L, Jiang T, Hamidi A, Gauto D, Recondo G, Rudin CM, DeLLphi-304 Investigators) N Engl J Med 2025 Jul 24;393(4):349-361 PMID: 40454646 SCOPUS ID: 2-s2.0-105012375634 06/02/2025       99 Citations
  • Cancer treatment paradigms in the precision medicine era. (Subbiah V, Curigliano G, Sicklick JK, Kato S, Tasken K, Medford A, Rieke DT, Chen HZ, Wahida A, Buschhorn L, Horgan D, Kurzrock R) Nat Med 2025 Nov;31(11):3609-3611 PMID: 40394190 SCOPUS ID: 2-s2.0-105005797459 05/21/2025       7 Citations
  • PD-1 transcriptomic landscape across cancers and implications for immune checkpoint blockade outcome. (Chen HZ, Kim NH, Nishizaki D, Nesline MK, Conroy JM, DePietro P, Pabla S, Kato S, Kurzrock R) NPJ Genom Med 2025 Mar 11;10(1):21 PMID: 40069238 PMCID: PMC11897377 SCOPUS ID: 2-s2.0-105000032476 03/12/2025       10 Citations
  • Successful Targeting of Somatic VHL Alterations With Belzutifan in Two Cases. (Thapa B, Shreenivas A, Bylow K, Chen HZ, George B, Kurzrock R) J Immunother Precis Oncol 2024 Nov;7(4):308-313 PMID: 39524464 PMCID: PMC11541926 SCOPUS ID: 2-s2.0-85208714820 11/14/2024       2 Citations
  • Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice. (Karan D, Dubey S, Gunewardena S, Iczkowski KA, Singh M, Liu P, Poletti A, Choo YM, Chen HZ, Hamann MT) Mol Oncol 2024 Aug;18(8):1966-1979 PMID: 38605607 PMCID: PMC11306517 SCOPUS ID: 2-s2.0-85190504464 04/12/2024       5 Citations
  • ALK fusions in the pan-cancer setting: another tumor-agnostic target? (Shreenivas A, Janku F, Gouda MA, Chen HZ, George B, Kato S, Kurzrock R) NPJ Precis Oncol 2023 Sep 29;7(1):101 PMID: 37773318 PMCID: PMC10542332 SCOPUS ID: 2-s2.0-85173930134 09/29/2023       79 Citations
  • Mainstreaming germline genetic testing for patients with pancreatic cancer increases uptake. (Ramsey ML, Tomlinson J, Pearlman R, Abushahin L, Aeilts A, Chen HZ, Chen Y, Compton A, Elkhatib R, Geiger L, Hays J, Jeter J, Jin N, Malalur P, Roychowdhury S, Ruple J, Prebish J, Stanich PP, Hampel H) Fam Cancer 2023 Jan;22(1):91-97 PMID: 35713757 PMCID: PMC9204376 SCOPUS ID: 2-s2.0-85132186768 06/18/2022       28 Citations
  • Effectiveness of a novel 1% glucose isotonic electrolyte solution for intraoperative fluid therapy in children: a randomized controlled trial. (Gao ZZ, Wang F, Hua L, Cui XH, Xu J, Fu WY, Chen HZ) J Int Med Res 2021 Nov;49(11):3000605211055624 PMID: 34775865 PMCID: PMC8593312 SCOPUS ID: 2-s2.0-85119428077 11/16/2021       3 Citations
  • Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy. (Chen HZ, Bonneville R, Paruchuri A, Reeser JW, Wing MR, Samorodnitsky E, Krook MA, Smith AM, Dao T, Miya J, Wang W, Yu L, Freud AG, Allenby P, Cole S, Otterson G, Shields P, Carbone DP, Roychowdhury S) JTO Clin Res Rep 2021 Apr;2(4):100164 PMID: 34590014 PMCID: PMC8474405 SCOPUS ID: 2-s2.0-85109556332 10/01/2021       17 Citations
  • Disparate Use of Chemoradiation in Elderly Patients With Localized Anal Cancer. (Miller ED, Nalin AP, Diaz Pardo DA, Arnett AL, Huang E, Gasior AC, Malalur P, Chen HZ, Williams TM, Bazan JG) J Natl Compr Canc Netw 2021 Jun 10;20(6):644-652.e2 PMID: 34111839 SCOPUS ID: 2-s2.0-85120318339 06/11/2021       8 Citations
  • Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. (Krook MA, Reeser JW, Ernst G, Barker H, Wilberding M, Li G, Chen HZ, Roychowdhury S) Br J Cancer 2021 Mar;124(5):880-892 PMID: 33268819 PMCID: PMC7921129 SCOPUS ID: 2-s2.0-85097055552 12/04/2020       293 Citations
  • Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing. (Bonneville R, Paruchuri A, Wing MR, Krook MA, Reeser JW, Chen HZ, Dao T, Samorodnitsky E, Smith AM, Yu L, Nowacki N, Chen W, Roychowdhury S) Mol Cancer Res 2021 Mar;19(3):465-474 PMID: 33229401 PMCID: PMC7939074 SCOPUS ID: 2-s2.0-85102273551 11/25/2020       7 Citations
  • Research Autopsy Demonstrates Polyclonal Acquired Resistance in a Patient With Metastatic GI Stromal Tumor. (Paruchuri A, Chen HZ, Bonneville R, Reeser JW, Wing MR, Krook MA, Samorodnitsky E, Miya J, Dao T, Smith A, Freud AG, Allenby P, Roychowdhury S) JCO Precis Oncol 2020;4 PMID: 32923900 PMCID: PMC7446505 SCOPUS ID: 2-s2.0-85086431176 09/15/2020       1 Citation
  • Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma. (Krook MA, Lenyo A, Wilberding M, Barker H, Dantuono M, Bailey KM, Chen HZ, Reeser JW, Wing MR, Miya J, Samorodnitsky E, Smith AM, Dao T, Martin DM, Ciombor KK, Hays J, Freud AG, Roychowdhury S) Mol Cancer Ther 2020 Mar;19(3):847-857 PMID: 31911531 PMCID: PMC7359896 SCOPUS ID: 2-s2.0-85081118898 01/09/2020       134 Citations
  • Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing. (Bonneville R, Krook MA, Chen HZ, Smith A, Samorodnitsky E, Wing MR, Reeser JW, Roychowdhury S) Methods Mol Biol 2020;2055:119-132 PMID: 31502149 PMCID: PMC7010320 SCOPUS ID: 2-s2.0-85071994590 09/11/2019       67 Citations
  • Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. (Krook MA, Bonneville R, Chen HZ, Reeser JW, Wing MR, Martin DM, Smith AM, Dao T, Samorodnitsky E, Paruchuri A, Miya J, Baker KR, Yu L, Timmers C, Dittmar K, Freud AG, Allenby P, Roychowdhury S) Cold Spring Harb Mol Case Stud 2019 Aug;5(4) PMID: 31371345 PMCID: PMC6672025 SCOPUS ID: 2-s2.0-85070757277 08/03/2019       76 Citations
  • Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer. (Krook MA, Barker H, Chen HZ, Reeser JW, Wing MR, Martin D, Smith AM, Dao T, Bonneville R, Samorodnitsky E, Miya J, Freud AG, Monk JP, Clinton SK, Roychowdhury S) Prostate Cancer Prostatic Dis 2019 Dec;22(4):624-632 PMID: 31043681 PMCID: PMC6824932 SCOPUS ID: 2-s2.0-85065245470 05/03/2019       7 Citations
  • Genomic characterization of metastatic ultra-hypermutated interdigitating dendritic cell sarcoma through rapid research autopsy. (Chen HZ, Bonneville R, Yu L, Wing MR, Reeser JW, Krook MA, Miya J, Samorodnitsky E, Smith A, Martin D, Dao T, Guo Q, Liebner D, Freud AG, Allenby P, Roychowdhury S) Oncotarget 2019 Jan 08;10(3):277-288 PMID: 30719225 PMCID: PMC6349455 SCOPUS ID: 2-s2.0-85059587644 02/06/2019       9 Citations
  • Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity. (Krook MA, Chen HZ, Bonneville R, Allenby P, Roychowdhury S) Trends Cancer 2019 Jan;5(1):1-5 PMID: 30616752 SCOPUS ID: 2-s2.0-85058443586 01/09/2019       11 Citations
  • Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor. (Carr DR, Pootrakul L, Chen HZ, Chung CG) JAMA Dermatol 2019 Jan 01;155(1):122-123 PMID: 30476938 SCOPUS ID: 2-s2.0-85057071190 11/27/2018       16 Citations
  • Implementing precision cancer medicine in the genomic era. (Chen HZ, Bonneville R, Roychowdhury S) Semin Cancer Biol 2019 Apr;55:16-27 PMID: 29857039 SCOPUS ID: 2-s2.0-85048771048 06/02/2018       33 Citations
  • Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma. (Chen HZ, Bertino EM, He K) J Thorac Dis 2017 Aug;9(8):2283-2285 PMID: 28932525 PMCID: PMC5594112 SCOPUS ID: 2-s2.0-85030100555 09/22/2017       5 Citations
  • Landscape of Microsatellite Instability Across 39 Cancer Types. (Bonneville R, Krook MA, Kautto EA, Miya J, Wing MR, Chen HZ, Reeser JW, Yu L, Roychowdhury S) JCO Precis Oncol 2017;2017 PMID: 29850653 PMCID: PMC5972025 SCOPUS ID: 2-s2.0-85042678461 01/01/2017       915 Citations
  • E2f8 mediates tumor suppression in postnatal liver development. (Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G) J Clin Invest 2016 Aug 01;126(8):2955-69 PMID: 27454291 PMCID: PMC4966321 SCOPUS ID: 2-s2.0-84987814871 07/28/2016       83 Citations
  • Canonical and atypical E2Fs regulate the mammalian endocycle. (Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G) Nat Cell Biol 2012 Nov;14(11):1192-202 PMID: 23064266 PMCID: PMC3616487 SCOPUS ID: 2-s2.0-84869079592 10/16/2012       136 Citations
  • Atypical E2F repressors and activators coordinate placental development. (Ouseph MM, Li J, Chen HZ, Pécot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G) Dev Cell 2012 Apr 17;22(4):849-62 PMID: 22516201 PMCID: PMC3483796 SCOPUS ID: 2-s2.0-84859872654 04/21/2012       87 Citations
  • Cell proliferation in the absence of E2F1-3. (Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G) Dev Biol 2011 Mar 01;351(1):35-45 PMID: 21185283 PMCID: PMC3868453 SCOPUS ID: 2-s2.0-79551681885 12/28/2010       60 Citations
  • Allele-specific tumor spectrum in pten knockin mice. (Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G) Proc Natl Acad Sci U S A 2010 Mar 16;107(11):5142-7 PMID: 20194734 PMCID: PMC2841921 SCOPUS ID: 2-s2.0-77950419842 03/03/2010       58 Citations
  • E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. (Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G) Nature 2009 Dec 17;462(7275):930-4 PMID: 20016602 PMCID: PMC2806193 SCOPUS ID: 2-s2.0-72449177341 12/18/2009       207 Citations
  • E2F3 is a mediator of DNA damage-induced apoptosis. (Martinez LA, Goluszko E, Chen HZ, Leone G, Post S, Lozano G, Chen Z, Chauchereau A) Mol Cell Biol 2010 Jan;30(2):524-36 PMID: 19917728 PMCID: PMC2798461 SCOPUS ID: 2-s2.0-73549095168 11/18/2009       70 Citations
  • Emerging roles of E2Fs in cancer: an exit from cell cycle control. (Chen HZ, Tsai SY, Leone G) Nat Rev Cancer 2009 Nov;9(11):785-97 PMID: 19851314 PMCID: PMC3616489 SCOPUS ID: 2-s2.0-70350518233 10/24/2009       883 Citations
  • Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. (Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W) Blood 2008 Aug 15;112(4):1013-21 PMID: 18523153 PMCID: PMC2515137 SCOPUS ID: 2-s2.0-51649084617 06/05/2008       190 Citations
  • Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. (Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A) Dev Cell 2008 Jan;14(1):62-75 PMID: 18194653 PMCID: PMC2253677 SCOPUS ID: 2-s2.0-37749005850 01/16/2008       191 Citations
  • Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. (Zhang X, Chen X, Song H, Chen HZ, Rovin BH) Eur J Immunol 2005 Nov;35(11):3258-67 PMID: 16220540 SCOPUS ID: 2-s2.0-27944437786 10/13/2005       90 Citations
  • Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. (Zhang X, Chen HZ, Rovin BH) Biotechniques 2003 Dec;35(6):1144-6, 1148 PMID: 14682047 SCOPUS ID: 2-s2.0-0344305634 12/20/2003       4 Citations
    • Last update: 02/16/2026