Medical College of Wisconsin
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Jack Kleinman MD

Jack Kleinman MD profile photo picture

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Medicine Nephrology

View Curriculum Vitae

Publications (66)

  • Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal. (Kolbach-Mandel AM, Mandel NS, Hoffmann BR, Kleinman JG, Wesson JA) Urolithiasis 2017 Aug;45(4):337-346 PMID: 28314883 PMCID: PMC5511579 SCOPUS ID: 2-s2.0-85015608912 03/21/2017       25 Citations
  • Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation. (Kolbach-Mandel AM, Mandel NS, Cohen SR, Kleinman JG, Ahmed F, Mandel IC, Wesson JA) Urolithiasis 2017 Apr;45(2):139-149 PMID: 27435233 PMCID: PMC8496968 SCOPUS ID: 2-s2.0-84978640626 07/21/2016       4 Citations
  • Exploring calcium oxalate crystallization: a constant composition approach. (Kolbach-Mandel AM, Kleinman JG, Wesson JA) Urolithiasis 2015 Oct;43(5):397-409 PMID: 26016572 PMCID: PMC4573792 SCOPUS ID: 2-s2.0-84941997196 05/29/2015       16 Citations
  • Relative deficiency of acidic isoforms of osteopontin from stone former urine. (Kolbach AM, Afzal O, Halligan B, Sorokina E, Kleinman JG, Wesson JA) Urol Res 2012 Oct;40(5):447-54 PMID: 22322528 PMCID: PMC4978133 SCOPUS ID: 2-s2.0-84867899105 02/11/2012       16 Citations
  • Mechanisms of Stone Formation. (Ratkalkar VN, Kleinman JG) Clin Rev Bone Miner Metab 2011 Dec;9(3-4):187-197 PMID: 22229020 PMCID: PMC3252394 SCOPUS ID: 2-s2.0-84855880785 01/10/2012       174 Citations
  • Calcium oxalate monohydrate aggregation induced by aggregation of desialylated Tamm-Horsfall protein. (Viswanathan P, Rimer JD, Kolbach AM, Ward MD, Kleinman JG, Wesson JA) Urol Res 2011 Aug;39(4):269-82 PMID: 21229239 PMCID: PMC3117096 SCOPUS ID: 2-s2.0-80051784471 01/14/2011       59 Citations
  • Induction of apoptosis with cisplatin enhances calcium oxalate crystal adherence to inner medullary collecting duct cells. (Kleinman JG, Sorokina EA, Wesson JA) Urol Res 2010 Apr;38(2):97-104 PMID: 20077109 SCOPUS ID: 2-s2.0-77953285660 01/16/2010       11 Citations
  • Acidic polyanion poly(acrylic acid) prevents calcium oxalate crystal deposition. (Kleinman JG, Alatalo LJ, Beshensky AM, Wesson JA) Kidney Int 2008 Oct;74(7):919-24 PMID: 18563053 PMCID: PMC2566899 SCOPUS ID: 2-s2.0-51849085221 06/20/2008       22 Citations
  • Telokin expression and the effect of hypoxia on its phosphorylation status in smooth muscle cells from small and large pulmonary arteries. (Madden JA, Dantuma MW, Sorokina EA, Weihrauch D, Kleinman JG) Am J Physiol Lung Cell Mol Physiol 2008 Jun;294(6):L1166-73 PMID: 18375742 SCOPUS ID: 2-s2.0-48949119353 04/01/2008       11 Citations
  • Bariatric surgery, hyperoxaluria, and nephrolithiasis: a plea for close postoperative management of risk factors. (Kleinman JG) Kidney Int 2007 Jul;72(1):8-10 PMID: 17597787 SCOPUS ID: 2-s2.0-34347340583 06/29/2007       19 Citations
  • Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers. (Wesson JA, Ganne V, Beshensky AM, Kleinman JG) Urol Res 2005 Jun;33(3):206-12 PMID: 15864572 SCOPUS ID: 2-s2.0-21244503882 05/03/2005       57 Citations
  • Osteopontin and calcium stone formation. (Kleinman JG, Wesson JA, Hughes J) Nephron Physiol 2004;98(2):p43-7 PMID: 15499214 SCOPUS ID: 2-s2.0-7544247556 10/23/2004       63 Citations
  • An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells. (Sorokina EA, Wesson JA, Kleinman JG) J Am Soc Nephrol 2004 Aug;15(8):2057-65 PMID: 15284292 SCOPUS ID: 2-s2.0-3543088021 07/31/2004       40 Citations
  • Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. (Wesson JA, Johnson RJ, Mazzali M, Beshensky AM, Stietz S, Giachelli C, Liaw L, Alpers CE, Couser WG, Kleinman JG, Hughes J) J Am Soc Nephrol 2003 Jan;14(1):139-47 PMID: 12506146 SCOPUS ID: 2-s2.0-12244271018 12/31/2002       265 Citations
  • Effects of urinary macromolecules on hydroxyapatite crystal formation. (Beshensky AM, Wesson JA, Worcester EM, Sorokina EJ, Snyder CJ, Kleinman JG) J Am Soc Nephrol 2001 Oct;12(10):2108-2116 PMID: 11562409 SCOPUS ID: 2-s2.0-0034823323 09/20/2001       35 Citations
  • Diagnostic value of iron indices in hemodialysis patients receiving epoetin. (Kaufman JS, Reda DJ, Fye CL, Goldfarb DS, Henderson WG, Kleinman JG, Vaamonde CA, Department of Veterans Affairs Cooperative Study Group on Erythropoietin in Hemodialysis Patients) Kidney Int 2001 Jul;60(1):300-8 PMID: 11422765 SCOPUS ID: 2-s2.0-0034955115 06/26/2001       20 Citations
  • Changes in smooth muscle cell pH during hypoxic pulmonary vasoconstriction: a possible role for ion transporters. (Madden JA, Keller PA, Kleinman JG) Physiol Res 2000;49(5):561-6 PMID: 11191360 SCOPUS ID: 2-s2.0-0033694695 02/24/2001       17 Citations
  • Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia. (Madden JA, Ray DE, Keller PA, Kleinman JG) Am J Physiol Lung Cell Mol Physiol 2001 Feb;280(2):L264-71 PMID: 11159005 SCOPUS ID: 2-s2.0-0035024643 02/13/2001       35 Citations
  • Role of anionic proteins in kidney stone formation: interaction between model anionic polypeptides and calcium oxalate crystals. (Wesson JA, Worcester EM, Kleinman JG) J Urol 2000 Apr;163(4):1343-8 PMID: 10737541 SCOPUS ID: 2-s2.0-0034108001 03/29/2000       61 Citations
  • Cloning and preliminary characterization of a calcium-binding protein closely related to nucleolin on the apical surface of inner medullary collecting duct cells. (Sorokina EA, Kleinman JG) J Biol Chem 1999 Sep 24;274(39):27491-6 PMID: 10488083 SCOPUS ID: 2-s2.0-0033600910 09/17/1999       39 Citations
  • Calcium oxalate crystal attachment to cultured kidney epithelial cell lines. (Bigelow MW, Wiessner JH, Kleinman JG, Mandel NS) J Urol 1998 Oct;160(4):1528-32 PMID: 9751407 SCOPUS ID: 2-s2.0-0032322526 09/29/1998       31 Citations
  • Subcutaneous compared with intravenous epoetin in patients receiving hemodialysis. Department of Veterans Affairs Cooperative Study Group on Erythropoietin in Hemodialysis Patients. (Kaufman JS, Reda DJ, Fye CL, Goldfarb DS, Henderson WG, Kleinman JG, Vaamonde CA) N Engl J Med 1998 Aug 27;339(9):578-83 PMID: 9718376 SCOPUS ID: 2-s2.0-0032572918 08/27/1998       285 Citations
  • Control of calcium oxalate crystal structure and cell adherence by urinary macromolecules. (Wesson JA, Worcester EM, Wiessner JH, Mandel NS, Kleinman JG) Kidney Int 1998 Apr;53(4):952-7 PMID: 9551403 SCOPUS ID: 2-s2.0-0031959536 04/29/1998       188 Citations
  • The dependence on membrane fluidity of calcium oxalate crystal attachment to IMCD membranes. (Bigelow MW, Wiessner JH, Kleinman JG, Mandel NS) Calcif Tissue Int 1997 Apr;60(4):375-9 PMID: 9075636 SCOPUS ID: 2-s2.0-0030952939 04/01/1997       34 Citations
  • Surface exposure of phosphatidylserine increases calcium oxalate crystal attachment to IMCD cells. (Bigelow MW, Wiessner JH, Kleinman JG, Mandel NS) Am J Physiol 1997 Jan;272(1 Pt 2):F55-62 PMID: 9039049 SCOPUS ID: 2-s2.0-0030867876 01/01/1997       83 Citations
  • Calcium oxalate-crystal membrane interactions: dependence on membrane lipid composition. (Bigelow MW, Wiessner JH, Kleinman JG, Mandel NS) J Urol 1996 Mar;155(3):1094-8 PMID: 8583571 SCOPUS ID: 2-s2.0-0030054306 03/01/1996       54 Citations
  • Expression of osteopontin, a urinary inhibitor of stone mineral crystal growth, in rat kidney. (Kleinman JG, Beshensky A, Worcester EM, Brown D) Kidney Int 1995 Jun;47(6):1585-96 PMID: 7643527 SCOPUS ID: 2-s2.0-0029048947 06/01/1995       88 Citations
  • Effect of serum proteins on sodium-linked transport processes in cultured kidney cells. (Blumenthal SS, Lewand DL, Tipnis PA, Kleinman JG) J Am Soc Nephrol 1995 May;5(11):1964-70 PMID: 7620094 SCOPUS ID: 2-s2.0-0028998748 05/01/1995       3 Citations
  • Upregulation of osteopontin expression by ischemia in rat kidney. (Kleinman JG, Worcester EM, Beshensky AM, Sheridan AM, Bonventre JV, Brown D) Ann N Y Acad Sci 1995 Apr 21;760:321-3 PMID: 7785909 SCOPUS ID: 2-s2.0-0029123181 04/21/1995       48 Citations
  • Osteopontin production by cultured kidney cells. (Worcester EM, Kleinman JG, Beshensky AM) Ann N Y Acad Sci 1995 Apr 21;760:266-78 PMID: 7785901 SCOPUS ID: 2-s2.0-0029143153 04/21/1995       10 Citations
  • Proton ATPases and urinary acidification. (Kleinman JG) J Am Soc Nephrol 1994 Nov;5(5 Suppl 1):S6-11 PMID: 7873748 SCOPUS ID: 2-s2.0-0028539342 11/01/1994       9 Citations
  • Effect of hypoxia and norepinephrine on cytoplasmic free Ca2+ in pulmonary and cerebral arterial myocytes. (Vadula MS, Kleinman JG, Madden JA) Am J Physiol 1993 Dec;265(6 Pt 1):L591-7 PMID: 8279575 SCOPUS ID: 2-s2.0-0027729672 12/01/1993       113 Citations
  • H(+)-K(+)-ATPase of rat inner medullary collecting duct in primary culture. (Kleinman JG, Tipnis P, Pscheidt R) Am J Physiol 1993 Nov;265(5 Pt 2):F698-704 PMID: 8238550 SCOPUS ID: 2-s2.0-0027142324 11/01/1993       29 Citations
  • Histochemical carbonic anhydrase in rat inner medullary collecting duct. (Kleinman JG, Bain JL, Fritsche C, Riley DA) J Histochem Cytochem 1992 Oct;40(10):1535-45 PMID: 1527374 SCOPUS ID: 2-s2.0-0026726129 10/01/1992       8 Citations
  • Cell polarity and calcium oxalate crystal adherence to cultured collecting duct cells. (Riese RJ, Mandel NS, Wiessner JH, Mandel GS, Becker CG, Kleinman JG) Am J Physiol 1992 Feb;262(2 Pt 2):F177-84 PMID: 1539682 SCOPUS ID: 2-s2.0-0026574299 02/01/1992       95 Citations
  • Carbonic anhydrase in turtle bladder mitochondrial-rich luminal and subluminal cells. (Fritsche C, Kleinman JG, Bain JL, Heinen RR, Riley DA) Am J Physiol 1991 Mar;260(3 Pt 2):F431-42 PMID: 1705756 SCOPUS ID: 2-s2.0-0025825312 03/01/1991       3 Citations
  • Carbonic anhydrase and proton secretion in turtle bladder mitochondrial-rich cells. (Fritsche C, Kleinman JG, Bain JL, Heinen RR, Riley DA) Am J Physiol 1991 Mar;260(3 Pt 2):F443-58 PMID: 1705757 SCOPUS ID: 2-s2.0-0025793387 03/01/1991       7 Citations
  • Regulation of cell pH and sodium transport in inner medullary collecting duct. (Kleinman JG) Semin Nephrol 1991 Jan;11(1):55-64 PMID: 1847751 SCOPUS ID: 2-s2.0-0026020874 01/01/1991       6 Citations
  • Uric acid crystal binding to renal inner medullary collecting duct cells in primary culture. (Riese RJ, Kleinman JG, Wiessner JH, Mandel GS, Mandel NS) J Am Soc Nephrol 1990 Aug;1(2):187-92 PMID: 2104262 SCOPUS ID: 2-s2.0-0025476671 08/01/1990       22 Citations
  • Cadmium inhibits glucose uptake in primary cultures of mouse cortical tubule cells. (Blumenthal SS, Lewand DL, Buday MA, Kleinman JG, Krezoski SK, Petering DH) Am J Physiol 1990 Jun;258(6 Pt 2):F1625-33 PMID: 2360656 SCOPUS ID: 2-s2.0-0025369670 06/01/1990       31 Citations
  • Effect of pH on growth of mouse renal cortical tubule cells in primary culture. (Blumenthal SS, Lewand DL, Buday MA, Mandel NS, Mandel GS, Kleinman JG) Am J Physiol 1989 Sep;257(3 Pt 1):C419-26 PMID: 2782385 SCOPUS ID: 2-s2.0-0024425452 09/01/1989       14 Citations
  • Sodium-proton exchange in human ileal brush-border membrane vesicles. (Ramaswamy K, Harig JM, Kleinman JG, Harris MS, Barry JA) Biochim Biophys Acta 1989 Jun 06;981(2):193-9 PMID: 2543457 SCOPUS ID: 2-s2.0-0024392338 06/06/1989       28 Citations
  • HCO3- secretion in mitochondria-rich cells is linked to an H+-ATPase. (Fritsche C, Schwartz JH, Heinen RR, Tietz R, Kleinman JG) Am J Physiol 1989 May;256(5 Pt 2):F869-74 PMID: 2524169 SCOPUS ID: 2-s2.0-0024369058 05/01/1989       1 Citation
  • Pyelonephritis complicating relapsing acute pancreatitis. (Brandes JC, Campbell DA, Kleinman JG) Am J Nephrol 1989;9(3):241-3 PMID: 2667364 SCOPUS ID: 2-s2.0-0024371847 01/01/1989       7 Citations
  • Specificity in calcium oxalate adherence to papillary epithelial cells in cultures. (Riese RJ, Riese JW, Kleinman JG, Wiessner JH, Mandel GS, Mandel NS) Am J Physiol 1988 Nov;255(5 Pt 2):F1025-32 PMID: 3056037 SCOPUS ID: 2-s2.0-0024271106 11/01/1988       84 Citations
  • Na+ and H+ transport in human jejunal brush-border membrane vesicles. (Kleinman JG, Harig JM, Barry JA, Ramaswamy K) Am J Physiol 1988 Aug;255(2 Pt 1):G206-11 PMID: 2841867 SCOPUS ID: 2-s2.0-0023707557 08/01/1988       30 Citations
  • Evidence that stimulation of 1,25(OH)2D3 production in primary cultures of mouse kidney cells by cyclic AMP requires new protein synthesis. (Korkor AB, Gray RW, Henry HL, Kleinman JG, Blumenthal SS, Garancis JC) J Bone Miner Res 1987 Dec;2(6):517-24 PMID: 2458676 SCOPUS ID: 2-s2.0-0023506622 12/01/1987       28 Citations
  • Regulation of pH in rat papillary tubule cells in primary culture. (Kleinman JG, Blumenthal SS, Wiessner JH, Reetz KL, Lewand DL, Mandel NS, Mandel GS, Garancis JC, Cragoe EJ Jr) J Clin Invest 1987 Dec;80(6):1660-9 PMID: 3680519 PMCID: PMC442437 SCOPUS ID: 2-s2.0-0023515488 12/01/1987       35 Citations
  • Proton gradient-dependent transport of glycine in rabbit renal brush-border membrane vesicles. (Rajendran VM, Barry JA, Kleinman JG, Ramaswamy K) J Biol Chem 1987 Nov 05;262(31):14974-7 PMID: 2822708 SCOPUS ID: 2-s2.0-0023645814 11/05/1987       33 Citations
  • Calcium oxalate crystal interaction with rat renal inner papillary collecting tubule cells. (Wiessner JH, Kleinman JG, Blumenthal SS, Garancis JC, Mandel GS, Mandel NS) J Urol 1987 Sep;138(3):640-3 PMID: 3625872 SCOPUS ID: 2-s2.0-0023281136 09/01/1987       32 Citations
  • Inflow time and recirculation in single-needle hemodialysis. (Blumenthal SS, Ortiz MA, Kleinman JG, Piering WF) Am J Kidney Dis 1986 Sep;8(3):202-6 PMID: 3752076 SCOPUS ID: 2-s2.0-0022979274 09/01/1986       7 Citations
  • Proximal tubule hydrogen ion transport processes in diuretic-induced metabolic alkalosis. (Blumenthal SS, Ware RA, Kleinman JG) J Lab Clin Med 1985 Jul;106(1):17-22 PMID: 4009020 SCOPUS ID: 2-s2.0-0022249943 07/01/1985       4 Citations
  • Sodium gradient-driven transport processes in ATP-depleted renal tubules. (Blumenthal SS, Ware RA, Kleinman JG) Am J Physiol 1983 May;244(5):C331-5 PMID: 6846524 SCOPUS ID: 2-s2.0-0020758187 05/01/1983       2 Citations
  • Anion transport regulates intracellular pH in renal cortical tissue. (Kleinman JG, Ware RA, Schwartz JH) Biochim Biophys Acta 1981 Oct 20;648(1):87-92 PMID: 6794625 SCOPUS ID: 2-s2.0-0019770951 10/20/1981       10 Citations
  • Treatment of the bleeding tendency in uremia with cryoprecipitate. (Maierhoter W, Adams MB, Kleinman JG, Roth DA) N Engl J Med 1981 Sep 10;305(11):645 PMID: 6790987 SCOPUS ID: 2-s2.0-0019792632 09/10/1981       10 Citations
  • Ameloblastoma of the maxilla with distant metastases and hypercalcemia. (Madiedo G, Choi H, Kleinman JG) Am J Clin Pathol 1981 Apr;75(4):585-91 PMID: 7223720 SCOPUS ID: 2-s2.0-0019467880 04/01/1981       46 Citations
  • Cell pH and acid transport in renal cortical tissue. (Kleinman JG, Brown WW, Ware RA, Schwartz JH) Am J Physiol 1980 Nov;239(5):F440-4 PMID: 7435618 SCOPUS ID: 2-s2.0-0019085705 11/01/1980       22 Citations
  • Acute renal failure associated with acetaminophen ingestion: report of a case and review of the literature. (Kleinman JG, Breitenfield RV, Roth DA) Clin Nephrol 1980 Oct;14(4):201-5 PMID: 7428194 SCOPUS ID: 2-s2.0-0018967811 10/01/1980       75 Citations
  • Production of maximally acid urine by the isolated dog kidney. (Kleinman JG, Ellis B, Teresi LM, Itskovitz HD) J Lab Clin Med 1979 Oct;94(4):600-7 PMID: 39105 SCOPUS ID: 2-s2.0-0018666868 10/01/1979    
  • Natriuretic and phosphaturic response to diuretics after parathyroidectomy in dogs. (Kleinman JG, McNeil JS, Hamburger RJ, Flamenbaum W) Eur J Pharmacol 1977 Nov 15;46(2):113-8 PMID: 590323 SCOPUS ID: 2-s2.0-0017737790 11/15/1977    
  • Effect of dithiothreitol on mercuric chloride- and uranyl nitrate-induced acute renal failure in the rat. (Kleinman JG, McNeil JS, Schwartz JH, Hamburger RJ, Flamenbaum W) Kidney Int 1977 Aug;12(2):115-21 PMID: 916500 SCOPUS ID: 2-s2.0-0017686413 08/01/1977       43 Citations
  • Effects of pent-4-enoic acid on renal free water, bicarbonate and phosphate excretion in the dog. (Kleinman JG, Levin ML) Clin Sci Mol Med 1975 Nov;49(5):409-17 PMID: 1192698 SCOPUS ID: 2-s2.0-0016582413 11/01/1975       3 Citations
  • Effect of KCl infusion on renin secretory rates and aldosterone excretion in dogs. (Flamenbaum W, Kleinman JG, McNeil JS, Hamburger RJ, Kotchen TA) Am J Physiol 1975 Aug;229(2):370-5 PMID: 1163662 SCOPUS ID: 2-s2.0-0016720495 08/01/1975       26 Citations
  • Uranyl nitrate acute renal failure in the dog: early changes in renal function and haemodynamics. (Kleinman JG, McNeil JS, Flamenbaum W) Clin Sci Mol Med 1975 Jan;48(1):9-16 PMID: 1112082 SCOPUS ID: 2-s2.0-0016583614 01/01/1975       13 Citations
  • Letter: Potassium, aldosterone and renin inter-relations. (Kleinman JG, Hamburger RJ, Schwartz JH, McNeil JS, Flamenbaum W) N Engl J Med 1974 Feb 14;290(7):408 PMID: 4358993 SCOPUS ID: 2-s2.0-0016391675 02/14/1974    
  • Renal functional effects of 4-pentenoic acid, an inhibitor of fatty acid oxidation. (Kleinman JG, Mandelbaum J, Levin ML) Am J Physiol 1973 Jan;224(1):95-101 PMID: 4683313 SCOPUS ID: 2-s2.0-0015545521 01/01/1973       8 Citations
    • Last update: 11/02/2018