Medical College of Wisconsin
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Jacob Wynne

Jacob Wynne profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Radiation Oncology

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0002-2034-7912


I am willing to collaborate on research projects.
I am willing to be a peer mentor.
I am willing to mentor a junior faculty member.

Research Areas of Interest

  • Artificial Intelligence
  • Data Mining
  • Machine Learning
  • Medical Informatics
  • Neural Networks (Computer)
  • Supervised Machine Learning
  • Unsupervised Machine Learning

    • Research Experience

  • Artificial Intelligence
  • Data Mining
  • Machine Learning
  • Medical Informatics
  • Neural Networks (Computer)
  • Supervised Machine Learning
  • Unsupervised Machine Learning

    • Clinical Expertise

  • Brain Neoplasms
  • Prostatic Neoplasms

    • Publications (34)

  • Recent advances in applying machine learning to proton radiotherapy. (Wildman VL, Wynne JF, Momin S, Kesarwala AH, Yang X) Biomed Phys Eng Express 2025 Jul 23;11(4) PMID: 40609552 PMCID: PMC12284894 SCOPUS ID: 2-s2.0-105011372968 07/04/2025       3 Citations
  • Automatic medical imaging segmentation via self-supervising large-scale convolutional neural networks. (Li Y, Wynne JF, Wu Y, Qiu RLJ, Tian S, Wang T, Patel PR, Yu DS, Yang X) Radiother Oncol 2025 Mar;204:110711 PMID: 39798701 PMCID: PMC11938206 SCOPUS ID: 2-s2.0-85214559147 01/12/2025       10 Citations
  • Prediction of early recurrence of adult-type diffuse gliomas following radiotherapy using multi-modal magnetic resonance images. (Salari E, Chen X, Wynne JF, Qiu RLJ, Roper J, Shu HK, Yang X) Med Phys 2024 Nov;51(11):8638-8648 PMID: 39221589 PMCID: PMC11530302 SCOPUS ID: 2-s2.0-85202927683 09/02/2024       5 Citations
  • Artificial intelligence-based motion tracking in cancer radiotherapy: A review. (Salari E, Wang J, Wynne JF, Chang CW, Wu Y, Yang X) J Appl Clin Med Phys 2024 Nov;25(11):e14500 PMID: 39194360 PMCID: PMC11540048 SCOPUS ID: 2-s2.0-85202574447 08/28/2024       12 Citations
  • High-resolution 3T to 7T ADC map synthesis with a hybrid CNN-transformer model. (Eidex Z, Wang J, Safari M, Elder E, Wynne J, Wang T, Shu HK, Mao H, Yang X) Med Phys 2024 Jun;51(6):4380-4388 PMID: 38630982 PMCID: PMC11650373 SCOPUS ID: 2-s2.0-85190961867 04/17/2024       8 Citations
  • Full-dose whole-body PET synthesis from low-dose PET using high-efficiency denoising diffusion probabilistic model: PET consistency model. (Pan S, Abouei E, Peng J, Qian J, Wynne JF, Wang T, Chang CW, Roper J, Nye JA, Mao H, Yang X) Med Phys 2024 Aug;51(8):5468-5478 PMID: 38588512 PMCID: PMC11321936 SCOPUS ID: 2-s2.0-85190376686 04/08/2024       28 Citations
  • MRI-based prostate cancer classification using 3D efficient capsule network. (Li Y, Wynne J, Wang J, Roper J, Chang CW, Patel AB, Shelton J, Liu T, Mao H, Yang X) Med Phys 2024 Jul;51(7):4748-4758 PMID: 38346111 PMCID: PMC12739645 SCOPUS ID: 2-s2.0-85185263888 02/12/2024       4 Citations
  • MRI-based Prostate Cancer Detection Using Cross-Shaped Windows Transformer (Li Y, Wynne J, Wang J, Qiu RLJ, Roper J, Pan S, Jani AB, Liu T, Patel PR, Mao H, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2024;12927 SCOPUS ID: 2-s2.0-85191429895 01/01/2024       1 Citation
  • Synthetic CT Generation from MRI Using 3D Improved Diffusion Model (Pan S, Abouei E, Wynne J, Wang T, Qiu RLJ, Li Y, Chang CW, Peng J, Qiu S, Roper J, Patel P, Yu DS, Mao H, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2024;12926 SCOPUS ID: 2-s2.0-85193529114 01/01/2024    
  • Synthetic CT generation from MRI using 3D transformer-based denoising diffusion model. (Pan S, Abouei E, Wynne J, Chang CW, Wang T, Qiu RLJ, Li Y, Peng J, Roper J, Patel P, Yu DS, Mao H, Yang X) Med Phys 2024 Apr;51(4):2538-2548 PMID: 38011588 PMCID: PMC10994752 SCOPUS ID: 2-s2.0-85177731234 11/27/2023       93 Citations
  • CBCT-Based synthetic CT image generation using conditional denoising diffusion probabilistic model. (Peng J, Qiu RLJ, Wynne JF, Chang CW, Pan S, Wang T, Roper J, Liu T, Patel PR, Yu DS, Yang X) Med Phys 2024 Mar;51(3):1847-1859 PMID: 37646491 PMCID: PMC11747767 SCOPUS ID: 2-s2.0-85169325210 08/30/2023       82 Citations
  • Early in vivo Radiation Damage Quantification for Pediatric Craniospinal Irradiation Using Longitudinal MRI for Intensity Modulated Proton Therapy. (Chang CW, Goette M, Kadom N, Wang Y, Wynne J, Wang T, Liu T, Esiashvili N, Zhou J, Eaton BR, Yang X) Adv Radiat Oncol 2023;8(5):101267 PMID: 37408668 PMCID: PMC10318210 SCOPUS ID: 2-s2.0-85160629604 07/06/2023       5 Citations
  • Rapid unpaired CBCT-based synthetic CT for CBCT-guided adaptive radiotherapy. (Wynne JF, Lei Y, Pan S, Wang T, Pasha M, Luca K, Roper J, Patel P, Patel SA, Godette K, Jani AB, Yang X) J Appl Clin Med Phys 2023 Oct;24(10):e14064 PMID: 37345557 PMCID: PMC10562022 SCOPUS ID: 2-s2.0-85163156167 06/22/2023       8 Citations
  • Impact of Age on Overall Survival Among Children With Wilms Tumor: A Population-based Registry Analysis. (Qian DC, Sykes-Martin KD, Tobillo R, Ali N, Wynne JF, Eaton BR, Paulino AC, Kalapurakal JA, Esiashvili N) Am J Clin Oncol 2023 May 01;46(5):213-218 PMID: 36856229 SCOPUS ID: 2-s2.0-85153803077 03/02/2023       10 Citations
  • Landmark tracking in liver US images using cascade convolutional neural networks with long short-term memory. (Zhang Y, Dai X, Tian Z, Lei Y, Wynne JF, Patel P, Chen Y, Liu T, Yang X) Meas Sci Technol 2023 May 01;34(5):054002 PMID: 36743834 PMCID: PMC9893725 SCOPUS ID: 2-s2.0-85147670019 02/07/2023       18 Citations
  • Patterns of Progression in Patients With Newly Diagnosed Glioblastoma Treated With 5-mm Margins in a Phase 1/2 Trial of 5-Fraction Stereotactic Radiosurgery With Concurrent and Adjuvant Temozolomide. (Mendoza MG, Azoulay M, Chang SD, Gibbs IC, Hancock SL, Pollom EL, Adler JR, Harraher C, Li G, Gephart MH, Nagpal S, Thomas RP, Recht LD, Jacobs LR, Modlin LA, Wynne J, Seiger K, Fujimoto D, Usoz M, von Eyben R, Choi CYH, Soltys SG) Pract Radiat Oncol 2023;13(3):e239-e245 PMID: 36736621 SCOPUS ID: 2-s2.0-85149702584 02/04/2023       18 Citations
  • A Vision-GNN Framework for Retinopathy Classification using Optical Coherence Tomography (Hu M, Wang J, Wynne J, Liu T, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2023;12465 SCOPUS ID: 2-s2.0-85160211812 01/01/2023       3 Citations
  • Multi-structure segmentation on cardiac MRI using multilayer perceptron mixer network (Pan S, Ma C, Chang CW, Wynne J, Roper J, Liu T, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2023;12468 SCOPUS ID: 2-s2.0-85160940773 01/01/2023       1 Citation
  • Deep Learning-based Multi-organ CT Segmentation with Adversarial Data Augmentation (Pan S, Lo SY, Huang M, Ma C, Wynne J, Wang T, Liu T, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2023;12464 SCOPUS ID: 2-s2.0-85159662297 01/01/2023    
  • Multi-organ CT Segmentation Using Shifted-window Multilayer Perceptron Mixer (Pan S, Wynne J, Hu M, Wang T, Roper J, Patel P, Liu T, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2023;12466 SCOPUS ID: 2-s2.0-85160853995 01/01/2023       1 Citation
  • Quantification of radiation damage for proton craniospinal irradiation using magnetic resonance imaging (Chang CW, Goette M, Kadom N, Wang Y, Wynne J, Wang T, Liu T, Esiashvili N, Zhou J, Eaton BR, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2023;12468 SCOPUS ID: 2-s2.0-85160947905 01/01/2023    
  • Abdomen CT multi-organ segmentation using token-based MLP-Mixer. (Pan S, Chang CW, Wang T, Wynne J, Hu M, Lei Y, Liu T, Patel P, Roper J, Yang X) Med Phys 2023 May;50(5):3027-3038 PMID: 36463516 PMCID: PMC10175083 SCOPUS ID: 2-s2.0-85144456095 12/05/2022       38 Citations
  • Male pelvic multi-organ segmentation using token-based transformer Vnet. (Pan S, Lei Y, Wang T, Wynne J, Chang CW, Roper J, Jani AB, Patel P, Bradley JD, Liu T, Yang X) Phys Med Biol 2022 Oct 14;67(20) PMID: 36170872 PMCID: PMC9671083 SCOPUS ID: 2-s2.0-85140324936 09/29/2022       39 Citations
  • Male Pelvic Multi-organ Segmentation Using V-transformer Network (Pan S, Lei Y, Wang T, Wynne J, Roper J, Jani AB, Patel P, Bradley JD, Liu T, Yang X) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2022;12036 SCOPUS ID: 2-s2.0-85132035427 01/01/2022       1 Citation
  • Phase I/II Dose-Escalation Trial of 3-Fraction Stereotactic Radiosurgery for Resection Cavities From Large Brain Metastases: Health-related Quality of Life Outcomes. (Rahimy E, Dudley SA, von Eyben R, Pollom EL, Seiger K, Modlin L, Wynne J, Fujimoto D, Jacobs LR, Chang SD, Gibbs IC, Hancock SL, Adler JR, Li G, Choi CYH, Soltys SG) Am J Clin Oncol 2021 Nov 01;44(11):588-595 PMID: 34670228 SCOPUS ID: 2-s2.0-85120152462 10/21/2021       6 Citations
  • Synthetic CT-aided multiorgan segmentation for CBCT-guided adaptive pancreatic radiotherapy. (Dai X, Lei Y, Wynne J, Janopaul-Naylor J, Wang T, Roper J, Curran WJ, Liu T, Patel P, Yang X) Med Phys 2021 Nov;48(11):7063-7073 PMID: 34609745 PMCID: PMC8595847 SCOPUS ID: 2-s2.0-85116898082 10/06/2021       30 Citations
  • Artificial intelligence in tumor subregion analysis based on medical imaging: A review. (Lin M, Wynne JF, Zhou B, Wang T, Lei Y, Curran WJ, Liu T, Yang X) J Appl Clin Med Phys 2021 Jul;22(7):10-26 PMID: 34164913 PMCID: PMC8292694 SCOPUS ID: 2-s2.0-85108363986 06/25/2021       28 Citations
  • A review on medical imaging synthesis using deep learning and its clinical applications. (Wang T, Lei Y, Fu Y, Wynne JF, Curran WJ, Liu T, Yang X) J Appl Clin Med Phys 2021 Jan;22(1):11-36 PMID: 33305538 PMCID: PMC7856512 SCOPUS ID: 2-s2.0-85097436933 12/12/2020       271 Citations
  • A phase I/II trial of 5-fraction stereotactic radiosurgery with 5-mm margins with concurrent temozolomide in newly diagnosed glioblastoma: primary outcomes. (Azoulay M, Chang SD, Gibbs IC, Hancock SL, Pollom EL, Harsh GR, Adler JR, Harraher C, Li G, Hayden Gephart M, Nagpal S, Thomas RP, Recht LD, Jacobs LR, Modlin LA, Wynne J, Seiger K, Fujimoto D, Usoz M, von Eyben R, Choi CYH, Soltys SG) Neuro Oncol 2020 Aug 17;22(8):1182-1189 PMID: 32002547 PMCID: PMC7594571 SCOPUS ID: 2-s2.0-85089710135 02/01/2020       48 Citations
  • Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation. (Buchwald ZS, Wynne J, Nasti TH, Zhu S, Mourad WF, Yan W, Gupta S, Khleif SN, Khan MK) Front Oncol 2018;8:612 PMID: 30619752 PMCID: PMC6306034 SCOPUS ID: 2-s2.0-85063253313 01/09/2019       186 Citations
  • Phase 1/2 Trial of 5-Fraction Stereotactic Radiosurgery With 5-mm Margins With Concurrent and Adjuvant Temozolomide in Newly Diagnosed Supratentorial Glioblastoma: Health-Related Quality of Life Results. (Pollom EL, Fujimoto D, Wynne J, Seiger K, Modlin LA, Jacobs LR, Azoulay M, von Eyben R, Tupper L, Gibbs IC, Hancock SL, Li G, Chang SD, Adler JR, Harsh GR, Harraher C, Nagpal S, Thomas RP, Recht LD, Choi CYH, Soltys SG) Int J Radiat Oncol Biol Phys 2017 May 01;98(1):123-130 PMID: 28586949 PMCID: PMC6193756 SCOPUS ID: 2-s2.0-85017298787 06/08/2017       22 Citations
  • Stereotactic ablative radiotherapy (SABR) for treatment of central and ultra-central lung tumors. (Chaudhuri AA, Tang C, Binkley MS, Jin M, Wynne JF, von Eyben R, Hara WY, Trakul N, Loo BW Jr, Diehn M) Lung Cancer 2015 Jul;89(1):50-6 PMID: 25997421 SCOPUS ID: 2-s2.0-84931569898 05/23/2015       163 Citations
  • Feasibility and potential utility of multicomponent exhaled breath analysis for predicting development of radiation pneumonitis after stereotactic ablative radiotherapy. (Moré JM, Eclov NCW, Chung MP, Wynne JF, Shorter JH, Nelson DD Jr, Hanlon AL, Burmeister R, Banos P, Maxim PG, Loo BW Jr, Diehn M) J Thorac Oncol 2014 Jul;9(7):957-964 PMID: 24926543 SCOPUS ID: 2-s2.0-84902522628 06/14/2014       8 Citations
  • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. (Newman AM, Bratman SV, To J, Wynne JF, Eclov NC, Modlin LA, Liu CL, Neal JW, Wakelee HA, Merritt RE, Shrager JB, Loo BW Jr, Alizadeh AA, Diehn M) Nat Med 2014 May;20(5):548-54 PMID: 24705333 PMCID: PMC4016134 SCOPUS ID: 2-s2.0-84903218109 04/08/2014       1915 Citations
    • Last update: 05/14/2026