Medical College of Wisconsin
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Jennifer D. Bruening MD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Otolaryngology and Communication Sciences

View Curriculum Vitae

Publications (33)

  • A Phase 1 Trial of Dose-Escalated Hypofractionated Adaptive Radiation Therapy With Atezolizumab for Advanced Head and Neck Cancers. (Awan M, Tarima S, Zenga J, Memon A, Paulson E, Shukla ME, Shreenivas A, Firat S, Massey B, Campbell B, Stadler M, Akakpo K, Bruening J, Bonate R, Stevens S, Elmont L, Schultz C, Wong S) Int J Radiat Oncol Biol Phys 2026 Jul 17 PMID: 42467032 07/17/2026    
  • Radiation-induced remodeling of the T cell landscape in head and neck cancer. (Memon AA, Said I, Norenberg E, Frei A, Foeckler J, Sun F, Dwinell MB, Lochhead RB, Bruening J, Akakpo K, Massey B, Wong SJ, Hematti P, Kearl TJ, Awan MJ, Himburg HA, Zenga J) Cancer Immunol Immunother 2026 Apr 15;75(5) PMID: 41984232 PMCID: PMC13083680 SCOPUS ID: 2-s2.0-105035819105 04/15/2026    
  • Radiation-Induced Loss of Tumor-Reactive T Cells Calls for More Rationally Designed Radioimmunotherapy Approaches. (Said I, Awan MJ, Wong SJ, Memon AA, Kearl T, Hematti P, Massey B, Bruening J, Akakpo K, Zenga J, Himburg HA) Int J Radiat Oncol Biol Phys 2026 Jan 01;124(1):190-193 PMID: 41391923 PMCID: PMC12939519 SCOPUS ID: 2-s2.0-105024206020 12/15/2025    
  • Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer. (Memon AA, Awan MJ, Espinosa OV, Kuehn R, Frei A, Foeckler J, Bruening J, Akakpo K, Massey B, Stadler M, Wong S, Himburg HA, Zenga J) JAMA Otolaryngol Head Neck Surg 2025 Dec 01;151(12):1196-1207 PMID: 41129177 PMCID: PMC12550742 SCOPUS ID: 2-s2.0-105022204542 10/23/2025       1 Citation
  • Tumoral Skin Invasion Is an Independent Predictor of Rapid Recurrence in Head and Neck Cancer. (Memon AA, Khalil M, Espinosa OV, Said I, Yang E, Adams JA, Friedland DR, Khani M, Luo J, Kuehn R, Frei A, Foeckler J, Akakpo K, Massey B, Stadler M, Wong S, Himburg HA, Awan MJ, Bruening J, Zenga J) Head Neck 2026 Feb;48(2):535-542 PMID: 41054923 SCOPUS ID: 2-s2.0-105018525815 10/07/2025       1 Citation
  • Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer. (Zenga J, Awan MJ, Frei A, Foeckler J, Kuehn R, Kasprzak J, Massey B, Bruening J, Akakpo K, Shukla M, Wong SJ, Mathison AJ, Wendt Andrae J, Hunt B, Puzyrenko A, Jin VX, Memon AA, Villarreal Espinosa O, Chen F, Shaheduzzaman M, Kearl T, Hematti P, Himburg HA) Nat Commun 2025 Jul 01;16(1):5660 PMID: 40593620 PMCID: PMC12219838 SCOPUS ID: 2-s2.0-105009625716 07/02/2025       5 Citations
  • Locked Dimerized CXCL12 Exerts Radiosensitizing Effects in Head and Neck Cancer. (Espinosa OV, Awan M, Memon AA, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Shukla M, Kasprzak J, Joshi A, Dwinell MB, Himburg HA, Zenga J) Head Neck 2025 May;47(5):1379-1391 PMID: 39722591 PMCID: PMC12040585 SCOPUS ID: 2-s2.0-85212965471 12/26/2024       1 Citation
  • Type I interferon signaling promotes radioresistance in head and neck cancer. (Zenga J, Awan MJ, Frei A, Massey B, Bruening J, Shukla M, Sharma GP, Shreenivas A, Wong SJ, Zimmermann MT, Mathison AJ, Himburg HA) Transl Cancer Res 2024 May 31;13(5):2535-2543 PMID: 38881922 PMCID: PMC11170510 SCOPUS ID: 2-s2.0-85195040296 06/17/2024       5 Citations
  • Corrigendum to Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture. (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Transl Oncol 2024 Jun;44:101927 PMID: 38641374 PMCID: PMC11391029 SCOPUS ID: 2-s2.0-85187349354 04/20/2024    
  • Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture. (Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Espinosa OV, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA) Transl Oncol 2024 Apr;42:101899 PMID: 38320395 PMCID: PMC10851216 SCOPUS ID: 2-s2.0-85184507548 02/07/2024       6 Citations
  • Comparison of da Vinci Single Port vs Si Systems for Transoral Robotic-Assisted Surgery: A Review With Technical Insights. (Oberhelman N, Bruening J, Jackson RS, Van Abel KM, Sumer B, Holsinger FC, Chan JYK, Gross ND, Clayburgh DR, Andersen PE, Li RJ) JAMA Otolaryngol Head Neck Surg 2024 Feb 01;150(2):165-171 PMID: 38127360 SCOPUS ID: 2-s2.0-85181003575 12/21/2023       27 Citations
  • Robotic Surgery in the Head and Neck: Presurgical Considerations and Post-treatment Appearance. (Bruening J) Semin Roentgenol 2023 Jul;58(3):374-383 PMID: 37507177 SCOPUS ID: 2-s2.0-85164323624 07/29/2023    
  • Photoactivated HPPH-Liposomal therapy for the treatment of HPV-Negative head and neck cancer. (Zenga J, Awan M, Hadi Razeghi Kondelaji M, Hansen C, Shafiee S, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Joshi A, Himburg HA) Oral Oncol 2023 Sep;144:106487 PMID: 37423200 PMCID: PMC10413333 SCOPUS ID: 2-s2.0-85164978149 07/10/2023       9 Citations
  • Monitoring postoperative ambulation and sleep after head and neck surgery: Feasibility and utility study using wearable devices. (Pandrangi VC, Jorizzo M, Shah S, Bruening J, Wax MK, Clayburgh D, Andersen P, Li RJ) Head Neck 2022 Dec;44(12):2744-2752 PMID: 36052957 SCOPUS ID: 2-s2.0-85137198630 09/03/2022       7 Citations
  • Osteocutaneous Radial Forearm Free Flap Fixed to a Prior Osteocutaneous Free Flap: Two Case Reports. (Kraimer K, Pandrangi V, Bruening J, Petrisor D, Wax MK) Laryngoscope 2022 Nov;132(11):2177-2179 PMID: 35848791 SCOPUS ID: 2-s2.0-85135041170 07/19/2022    
  • Effect of Virtual Reality on Pain Management and Opioid Use Among Hospitalized Patients After Head and Neck Surgery: A Randomized Clinical Trial. (Pandrangi VC, Shah SN, Bruening JD, Wax MK, Clayburgh D, Andersen PE, Li RJ) JAMA Otolaryngol Head Neck Surg 2022 Aug 01;148(8):724-730 PMID: 35679057 PMCID: PMC9185522 SCOPUS ID: 2-s2.0-85132542692 06/10/2022       50 Citations
  • A phase 2 trial of a topical antiseptic bundle in head and neck cancer surgery: Effects on surgical site infection and the oral microbiome. (Zenga J, Atkinson S, Yen T, Massey B, Stadler M, Bruening J, Peppard W, Reuben M, Hayward M, Mesich B, Buchan B, Ledeboer N, Sanchez JL, Fraser R, Lin CW, Holtz ML, Awan M, Wong SJ, Puram SV, Salzman N) EBioMedicine 2022 Jul;81:104099 PMID: 35671624 PMCID: PMC9168040 SCOPUS ID: 2-s2.0-85131428877 06/08/2022       12 Citations
  • Perioperative Topical Antisepsis and Surgical Site Infection in Patients Undergoing Upper Aerodigestive Tract Reconstruction. (Beydoun AS, Koss K, Nielsen T, Holcomb AJ, Pichardo P, Purdy N, Zebolsky AL, Heaton CM, McMullen CP, Yesensky JA, Moore MG, Goyal N, Kohan J, Sajisevi M, Tan K, Petrisor D, Wax MK, Kejner AE, Hassan Z, Trott S, Larson A, Richmon JD, Graboyes EM, Wood CB, Jackson RS, Pipkorn P, Bruening J, Massey B, Puram SV, Zenga J) JAMA Otolaryngol Head Neck Surg 2022 Jun 01;148(6):547-554 PMID: 35476816 PMCID: PMC9047735 SCOPUS ID: 2-s2.0-85129444547 04/28/2022       7 Citations
  • Soft Tissue Reconstruction of Parotidectomy Defect. (Moy J, Wax MK, Loyo M) Otolaryngol Clin North Am 2021 Jun;54(3):567-581 PMID: 34024484 SCOPUS ID: 2-s2.0-85106708222 05/25/2021       7 Citations
  • Approach to the Patient with Unknown Primary Squamous Cell Carcinoma of the Head and Neck. (Moy J, Li R) Curr Treat Options Oncol 2020 Oct 06;21(12):93 PMID: 33025214 SCOPUS ID: 2-s2.0-85092021588 10/08/2020       7 Citations
  • Application of the Spider Limb Positioner to Subscapular System Free Flaps. (Bender-Heine A, Young G, Moy J, Weedman S, Wax MK) Laryngoscope 2021 Mar;131(3):525-528 PMID: 32833233 SCOPUS ID: 2-s2.0-85089735122 08/25/2020       12 Citations
  • Radial Forearm Free Tissue Transfer to Clival Defect. (Moy JD, Gardner PA, Sridharan S, Wang EW) J Neurol Surg B Skull Base 2019 Dec;80(Suppl 4):S380-S381 PMID: 31750070 PMCID: PMC6864404 SCOPUS ID: 2-s2.0-85075372444 11/22/2019       15 Citations
  • PD-L1 Mediates Dysfunction in Activated PD-1+ NK Cells in Head and Neck Cancer Patients. (Concha-Benavente F, Kansy B, Moskovitz J, Moy J, Chandran U, Ferris RL) Cancer Immunol Res 2018 Dec;6(12):1548-1560 PMID: 30282672 PMCID: PMC6512340 SCOPUS ID: 2-s2.0-85057807901 10/05/2018       150 Citations
  • Immunotherapy for Head and Neck Squamous Cell Carcinoma. (Moskovitz J, Moy J, Ferris RL) Curr Oncol Rep 2018 Mar 03;20(2):22 PMID: 29502288 PMCID: PMC5835060 SCOPUS ID: 2-s2.0-85048251970 03/05/2018       139 Citations
  • Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC) (Moy J, Ferris RL) Current Cancer Research 2018:365-396 SCOPUS ID: 2-s2.0-85111797787 01/01/2018    
  • PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. (Kansy BA, Concha-Benavente F, Srivastava RM, Jie HB, Shayan G, Lei Y, Moskovitz J, Moy J, Li J, Brandau S, Lang S, Schmitt NC, Freeman GJ, Gooding WE, Clump DA, Ferris RL) Cancer Res 2017 Nov 15;77(22):6353-6364 PMID: 28904066 PMCID: PMC5690836 SCOPUS ID: 2-s2.0-85033795095 09/15/2017       209 Citations
  • Immunotherapy for Head and Neck Squamous Cell Carcinoma: A Review of Current and Emerging Therapeutic Options. (Moskovitz JM, Moy J, Seiwert TY, Ferris RL) Oncologist 2017 Jun;22(6):680-693 PMID: 28507203 PMCID: PMC5469583 SCOPUS ID: 2-s2.0-85020905767 05/17/2017       25 Citations
  • Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma. (Moy JD, Moskovitz JM, Ferris RL) Eur J Cancer 2017 May;76:152-166 PMID: 28324750 PMCID: PMC5459368 SCOPUS ID: 2-s2.0-85015448123 03/23/2017       91 Citations
  • Response to "Management and outcomes in patients affected by malignant otitis externa". (McCall AA, Hobson CE, Moy JD, Byers KE, Raz Y, Hirsch BE) Otolaryngol Head Neck Surg 2014 Nov;151(5):890-1 PMID: 25344096 SCOPUS ID: 2-s2.0-84908689718 10/26/2014       1 Citation
  • Malignant Otitis Externa: Evolving Pathogens and Implications for Diagnosis and Treatment. (Hobson CE, Moy JD, Byers KE, Raz Y, Hirsch BE, McCall AA) Otolaryngol Head Neck Surg 2014 Jul;151(1):112-6 PMID: 24675790 SCOPUS ID: 2-s2.0-84908670675 03/29/2014       72 Citations
  • Responses of vestibular nucleus neurons to inputs from the hindlimb are enhanced following a bilateral labyrinthectomy. (McCall AA, Moy JD, Puterbaugh SR, DeMayo WM, Yates BJ) J Appl Physiol (1985) 2013 Mar 15;114(6):742-51 PMID: 23305979 PMCID: PMC3615601 SCOPUS ID: 2-s2.0-84878578454 01/12/2013       8 Citations
  • Processing of vestibular inputs by the medullary lateral tegmental field of conscious cats: implications for generation of motion sickness. (McCall AA, Moy JD, DeMayo WM, Puterbaugh SR, Miller DJ, Catanzaro MF, Yates BJ) Exp Brain Res 2013 Mar;225(3):349-59 PMID: 23274644 PMCID: PMC3594386 SCOPUS ID: 2-s2.0-84877061292 01/01/2013       9 Citations
  • Responses of neurons in the caudal medullary lateral tegmental field to visceral inputs and vestibular stimulation in vertical planes. (Moy JD, Miller DJ, Catanzaro MF, Boyle BM, Ogburn SW, Cotter LA, Yates BJ, McCall AA) Am J Physiol Regul Integr Comp Physiol 2012 Nov 01;303(9):R929-40 PMID: 22955058 PMCID: PMC3517700 SCOPUS ID: 2-s2.0-84868379223 09/08/2012       14 Citations
    • Last update: 07/22/2026