Medical College of Wisconsin
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Jennifer J. Tuscher PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology


I am willing to collaborate on research projects.

Publications (35)

  • Morphine regulates astrocyte transcriptional dynamics in the ventral tegmental area by stimulation of glucocorticoid signaling. (Tuscher JJ, Cleere A, Phillips RA 3rd, Newman CE, Twa G, Robinson NJ, Ianov L, Sorge RE, Day JJ) bioRxiv 2025 Sep 22 PMID: 41040164 PMCID: PMC12485804 10/03/2025    
  • Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward. (Brida KL, Jorgensen ET, Robert A Phillips Iii, Newman CE, Tuscher JJ, Morring EK, Zipperly ME, Ianov L, Montgomery KD, Tippani M, Hyde TM, Maynard KR, Martinowich K, Day JJ) Sci Adv 2025 Mar 28;11(13):eads4441 PMID: 40138397 PMCID: PMC12076537 SCOPUS ID: 2-s2.0-105001287951 03/27/2025       1 Citation
  • Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward. (Brida KL, Jorgensen ET, Phillips RA, Newman CE, Tuscher JJ, Morring EK, Zipperly ME, Ianov L, Montgomery KD, Tippani M, Hyde TM, Maynard KR, Martinowich K, Day JJ) bioRxiv 2024 Jun 18 PMID: 38948801 PMCID: PMC11212904 07/01/2024    
  • Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons. (Bach SV, Bauman AJ, Hosein D, Tuscher JJ, Ianov L, Greathouse KM, Henderson BW, Herskowitz JH, Martinowich K, Day JJ) Hippocampus 2024 May;34(5):218-229 PMID: 38362938 PMCID: PMC11039386 SCOPUS ID: 2-s2.0-85185689283 02/16/2024       11 Citations
  • Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer. (Phillips RA, Wan E, Tuscher JJ, Reid D, Drake OR, Ianov L, Day JJ) Elife 2023 Nov 08;12 PMID: 37938195 PMCID: PMC10631760 SCOPUS ID: 2-s2.0-85176737811 11/08/2023       9 Citations
  • Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer. (Phillips RA 3rd, Wan E, Tuscher JJ, Reid D, Drake OR, Ianov L, Day JJ) bioRxiv 2023 Aug 21 PMID: 37333110 PMCID: PMC10274686 06/19/2023    
  • Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons. (Bach SV, Bauman AJ, Hosein D, Tuscher JJ, Ianov L, Greathouse KM, Henderson BW, Herskowitz JH, Martinowich K, Day JJ) bioRxiv 2023 Apr 05 PMID: 37066216 PMCID: PMC10104043 04/18/2023    
  • Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length. (Walker CK, Greathouse KM, Tuscher JJ, Dammer EB, Weber AJ, Liu E, Curtis KA, Boros BD, Freeman CD, Seo JV, Ramdas R, Hurst C, Duong DM, Gearing M, Murchison CF, Day JJ, Seyfried NT, Herskowitz JH) J Neurosci 2023 May 17;43(20):3764-3785 PMID: 37055180 PMCID: PMC10198456 SCOPUS ID: 2-s2.0-85159768655 04/14/2023       8 Citations
  • Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine. (Phillips RA 3rd, Tuscher JJ, Fitzgerald ND, Wan E, Zipperly ME, Duke CG, Ianov L, Day JJ) Mol Cell Neurosci 2023 Jun;125:103849 PMID: 36965548 PMCID: PMC10898607 SCOPUS ID: 2-s2.0-85151014076 03/26/2023       31 Citations
  • Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine. (Phillips RA 3rd, Tuscher JJ, Fitzgerald ND, Wan E, Zipperly ME, Duke CG, Ianov L, Day JJ) bioRxiv 2023 Jan 13 PMID: 36711527 PMCID: PMC9882178 01/31/2023    
  • An atlas of transcriptionally defined cell populations in the rat ventral tegmental area. (Phillips RA 3rd, Tuscher JJ, Black SL, Andraka E, Fitzgerald ND, Ianov L, Day JJ) Cell Rep 2022 Apr 05;39(1):110616 PMID: 35385745 PMCID: PMC10888206 SCOPUS ID: 2-s2.0-85127492764 04/07/2022       57 Citations
  • A Cre-Dependent CRISPR/dCas9 System for Gene Expression Regulation in Neurons. (Carullo NVN, Hinds JE, Revanna JS, Tuscher JJ, Bauman AJ, Day JJ) eNeuro 2021;8(4) PMID: 34321217 PMCID: PMC8376295 SCOPUS ID: 2-s2.0-85113158892 07/30/2021       18 Citations
  • Morphine, the microbiome, and fatty acids: short chains make a big link in opioid reward. (Tuscher JJ, Day JJ) Neuropsychopharmacology 2021 Nov;46(12):2039-2040 PMID: 34239049 PMCID: PMC8505438 SCOPUS ID: 2-s2.0-85109840595 07/10/2021       3 Citations
  • A dopamine-induced gene expression signature regulates neuronal function and cocaine response. (Savell KE, Tuscher JJ, Zipperly ME, Duke CG, Phillips RA 3rd, Bauman AJ, Thukral S, Sultan FA, Goska NA, Ianov L, Day JJ) Sci Adv 2020 Jun;6(26):eaba4221 PMID: 32637607 PMCID: PMC7314536 SCOPUS ID: 2-s2.0-85087503928 07/09/2020       117 Citations
  • Blue Light-Induced Gene Expression Alterations in Cultured Neurons Are the Result of Phototoxic Interactions with Neuronal Culture Media. (Duke CG, Savell KE, Tuscher JJ, Phillips RA 3rd, Day JJ) eNeuro 2020;7(1) PMID: 31879366 PMCID: PMC6946540 SCOPUS ID: 2-s2.0-85077485605 12/28/2019       17 Citations
  • Multigenerational epigenetic inheritance: One step forward, two generations back. (Tuscher JJ, Day JJ) Neurobiol Dis 2019 Dec;132:104591 PMID: 31470104 SCOPUS ID: 2-s2.0-85071543442 08/31/2019       48 Citations
  • Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism. (Yousuf H, Smies CW, Hafenbreidel M, Tuscher JJ, Fortress AM, Frick KM, Mueller D) Front Behav Neurosci 2019;13:168 PMID: 31417375 PMCID: PMC6684748 SCOPUS ID: 2-s2.0-85072735423 08/17/2019       22 Citations
  • Chemogenetic Suppression of Medial Prefrontal-Dorsal Hippocampal Interactions Prevents Estrogenic Enhancement of Memory Consolidation in Female Mice. (Tuscher JJ, Taxier LR, Schalk JC, Haertel JM, Frick KM) eNeuro 2019;6(2) PMID: 31016230 PMCID: PMC6477593 SCOPUS ID: 2-s2.0-85065038381 04/25/2019       22 Citations
  • A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation. (Savell KE, Bach SV, Zipperly ME, Revanna JS, Goska NA, Tuscher JJ, Duke CG, Sultan FA, Burke JN, Williams D, Ianov L, Day JJ) eNeuro 2019;6(1) PMID: 30863790 PMCID: PMC6412672 SCOPUS ID: 2-s2.0-85062890227 03/14/2019       103 Citations
  • Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice. (Tuscher JJ, Taxier LR, Fortress AM, Frick KM) Neurobiol Learn Mem 2018 Dec;156:103-116 PMID: 30408525 PMCID: PMC7310386 SCOPUS ID: 2-s2.0-85056743601 11/09/2018       76 Citations
  • 17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors. (Doncheck EM, Urbanik LA, DeBaker MC, Barron LM, Liddiard GT, Tuscher JJ, Frick KM, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2018 Mar;43(4):781-790 PMID: 28825421 PMCID: PMC5809785 SCOPUS ID: 2-s2.0-85041731033 08/22/2017       36 Citations
  • Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females. (Frick KM, Tuscher JJ, Koss WA, Kim J, Taxier LR) Physiol Behav 2018 Apr 01;187:57-66 PMID: 28755863 PMCID: PMC5787049 SCOPUS ID: 2-s2.0-85026540702 08/02/2017       52 Citations
  • Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice. (Tuscher JJ, Szinte JS, Starrett JR, Krentzel AA, Fortress AM, Remage-Healey L, Frick KM) Horm Behav 2016 Jul;83:60-67 PMID: 27178577 PMCID: PMC4915975 SCOPUS ID: 2-s2.0-84971432678 05/15/2016       119 Citations
  • Estradiol-Mediated Spine Changes in the Dorsal Hippocampus and Medial Prefrontal Cortex of Ovariectomized Female Mice Depend on ERK and mTOR Activation in the Dorsal Hippocampus. (Tuscher JJ, Luine V, Frankfurt M, Frick KM) J Neurosci 2016 Feb 03;36(5):1483-9 PMID: 26843632 PMCID: PMC4737764 SCOPUS ID: 2-s2.0-84957837222 02/05/2016       133 Citations
  • The genome of the vervet (Chlorocebus aethiops sabaeus). (Warren WC, Jasinska AJ, García-Pérez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O, Minx P, Montague MJ, Kyung K, Hillier LW, Kremitzki M, Graves T, Chiang C, Hughes J, Tran N, Huang Y, Ramensky V, Choi OW, Jung YJ, Schmitt CA, Juretic N, Wasserscheid J, Turner TR, Wiseman RW, Tuscher JJ, Karl JA, Schmitz JE, Zahn R, O'Connor DH, Redmond E, Nisbett A, Jacquelin B, Müller-Trutwin MC, Brenchley JM, Dione M, Antonio M, Schroth GP, Kaplan JR, Jorgensen MJ, Thomas GW, Hahn MW, Raney BJ, Aken B, Nag R, Schmitz J, Churakov G, Noll A, Stanyon R, Webb D, Thibaud-Nissen F, Nordborg M, Marques-Bonet T, Dewar K, Weinstock GM, Wilson RK, Freimer NB) Genome Res 2015 Dec;25(12):1921-33 PMID: 26377836 PMCID: PMC4665013 SCOPUS ID: 2-s2.0-84956708874 09/18/2015       74 Citations
  • Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents. (Frick KM, Kim J, Tuscher JJ, Fortress AM) Learn Mem 2015 Sep;22(9):472-93 PMID: 26286657 PMCID: PMC4561402 SCOPUS ID: 2-s2.0-84942106437 08/20/2015       174 Citations
  • Regulation of object recognition and object placement by ovarian sex steroid hormones. (Tuscher JJ, Fortress AM, Kim J, Frick KM) Behav Brain Res 2015 May 15;285:140-57 PMID: 25131507 PMCID: PMC4329280 SCOPUS ID: 2-s2.0-84925365895 08/19/2014       108 Citations
  • Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats. (Hafenbreidel M, Rafa Todd C, Twining RC, Tuscher JJ, Mueller D) Psychopharmacology (Berl) 2014 Dec;231(24):4585-94 PMID: 24847958 PMCID: PMC4233003 SCOPUS ID: 2-s2.0-84939891929 05/23/2014       17 Citations
  • Canonical Wnt signaling is necessary for object recognition memory consolidation. (Fortress AM, Schram SL, Tuscher JJ, Frick KM) J Neurosci 2013 Jul 31;33(31):12619-26 PMID: 23904598 PMCID: PMC6618550 SCOPUS ID: 2-s2.0-84880849552 08/02/2013       100 Citations
  • 17β-estradiol is necessary for extinction of cocaine seeking in female rats. (Twining RC, Tuscher JJ, Doncheck EM, Frick KM, Mueller D) Learn Mem 2013 May 15;20(6):300-6 PMID: 23676202 SCOPUS ID: 2-s2.0-84879316688 05/17/2013       28 Citations
  • Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. (Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G) Am J Transplant 2010 Jun;10(6):1375-84 PMID: 20486921 PMCID: PMC2893326 SCOPUS ID: 2-s2.0-77952928951 05/22/2010       57 Citations
  • MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques. (O'Connor SL, Lhost JJ, Becker EA, Detmer AM, Johnson RC, Macnair CE, Wiseman RW, Karl JA, Greene JM, Burwitz BJ, Bimber BN, Lank SM, Tuscher JJ, Mee ET, Rose NJ, Desrosiers RC, Hughes AL, Friedrich TC, Carrington M, O'Connor DH) Sci Transl Med 2010 Mar 10;2(22):22ra18 PMID: 20375000 PMCID: PMC2865159 SCOPUS ID: 2-s2.0-77952992644 04/09/2010       80 Citations
  • Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques. (Bolton DL, Minang JT, Trivett MT, Song K, Tuscher JJ, Li Y, Piatak M Jr, O'Connor D, Lifson JD, Roederer M, Ohlen C) J Immunol 2010 Jan 01;184(1):303-14 PMID: 19949089 PMCID: PMC2797565 SCOPUS ID: 2-s2.0-73949102416 12/02/2009       33 Citations
  • Major histocompatibility complex genotyping with massively parallel pyrosequencing. (Wiseman RW, Karl JA, Bimber BN, O'Leary CE, Lank SM, Tuscher JJ, Detmer AM, Bouffard P, Levenkova N, Turcotte CL, Szekeres E Jr, Wright C, Harkins T, O'Connor DH) Nat Med 2009 Nov;15(11):1322-6 PMID: 19820716 PMCID: PMC2824247 SCOPUS ID: 2-s2.0-70449134621 10/13/2009       132 Citations
  • Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing. (O'Leary CE, Wiseman RW, Karl JA, Bimber BN, Lank SM, Tuscher JJ, O'Connor DH) Immunogenetics 2009 Oct;61(10):689-701 PMID: 19777225 PMCID: PMC2813950 SCOPUS ID: 2-s2.0-70350539297 09/25/2009       31 Citations
    • Last update: 02/15/2026