Medical College of Wisconsin
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Jesse G. Meyer PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center


Research Experience

  • Acetyl Coenzyme A
  • Acetylation
  • Acylation
  • Amino Acid Sequence
  • Energy Metabolism
  • Escherichia coli
  • Glucose
  • Liver
  • Lysine
  • Machine Learning
  • Mass Spectrometry
  • Metabolism
  • Metabolomics
  • Mitochondria
  • Mitochondria, Liver
  • Mitochondrial Proteins
  • Molecular Sequence Data
  • Peptides
  • Protein Processing, Post-Translational
  • Proteins
  • Proteome
  • Proteomics
  • Serine Endopeptidases
  • Sirtuins
  • Substrate Specificity
  • Succinic Acid
  • Supervised Machine Learning
  • Tandem Mass Spectrometry
  • Trypsin
  • Unsupervised Machine Learning
  • Workflow
  • metabolism
  • Methodologies and Techniques

  • Acetylation
  • Acylation
  • Mass Spectrometry
  • Mitochondria
  • Mitochondrial Proteins
  • Peptides
  • Protein Processing, Post-Translational
  • Proteins
  • Proteome
  • Proteomics
  • Serine Endopeptidases
  • Sirtuins
  • Substrate Specificity
  • Tandem Mass Spectrometry
  • Publications (26)

  • Qualitative and Quantitative Shotgun Proteomics Data Analysis from Data-Dependent Acquisition Mass Spectrometry. (Meyer JG) Methods Mol Biol 2021;2259:297-308 PMID: 33687723 03/10/2021    
  • Peptide Correlation Analysis (PeCorA) Reveals Differential Proteoform Regulation. (Dermit M, Peters-Clarke TM, Shishkova E, Meyer JG) J Proteome Res 2021 04 02;20(4):1972-1980 PMID: 33325715 12/17/2020       1 Citation
  • Quantitative shotgun proteome analysis by direct infusion. (Meyer JG, Niemi NM, Pagliarini DJ, Coon JJ) Nat Methods 2020 12;17(12):1222-1228 PMID: 33230323 PMCID: PMC8009190 11/25/2020       2 Citations
  • SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. (Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E) Nat Commun 2020 11 23;11(1):5927 PMID: 33230181 PMCID: PMC7684291 11/25/2020    
  • Large-Scale Multi-omic Analysis of COVID-19 Severity. (Overmyer KA, Shishkova E, Miller IJ, Balnis J, Bernstein MN, Peters-Clarke TM, Meyer JG, Quan Q, Muehlbauer LK, Trujillo EA, He Y, Chopra A, Chieng HC, Tiwari A, Judson MA, Paulson B, Brademan DR, Zhu Y, Serrano LR, Linke V, Drake LA, Adam AP, Schwartz BS, Singer HA, Swanson S, Mosher DF, Stewart R, Coon JJ, Jaitovich A) Cell Syst 2021 01 20;12(1):23-40.e7 PMID: 33096026 PMCID: PMC7543711 10/24/2020       23 Citations
  • Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species. (Meyer JG, Garcia TY, Schilling B, Gibson BW, Lamba DA) Sci Rep 2019 10 28;9(1):15440 PMID: 31659173 PMCID: PMC6817852 10/30/2019       6 Citations
  • Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. (Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, Cohen DE, Kahn CR) Cell Metab 2019 10 01;30(4):735-753.e4 PMID: 31577934 PMCID: PMC7816129 10/03/2019       32 Citations
  • Learning Drug Functions from Chemical Structures with Convolutional Neural Networks and Random Forests. (Meyer JG, Liu S, Miller IJ, Coon JJ, Gitter A) J Chem Inf Model 2019 10 28;59(10):4438-4449 PMID: 31518132 PMCID: PMC6819987 09/14/2019       12 Citations
  • High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets. (Schilling B, Meyer JG, Wei L, Ott M, Verdin E) Methods Mol Biol 2019;1983:3-16 PMID: 31087289 PMCID: PMC6825508 05/16/2019       3 Citations
  • Fast Proteome Identification and Quantification from Data-Dependent Acquisition-Tandem Mass Spectrometry (DDA MS/MS) Using Free Software Tools. (Meyer JG) Methods Protoc 2019 Mar;2(1) PMID: 31008411 PMCID: PMC6469856 04/23/2019    
  • Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. (Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR) Mol Cell 2019 05 16;74(4):844-857.e7 PMID: 31000437 PMCID: PMC6525068 04/20/2019       27 Citations
  • Correction for Christensen et al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli". (Christensen DG, Meyer JG, Baumgartner JT, D'Souza AK, Nelson WC, Payne SH, Kuhn ML, Schilling B, Wolfe AJ) mBio 2019 04 09;10(2) PMID: 30967468 PMCID: PMC6456757 04/11/2019    
  • Glycemic Control in Adult Surgical Patients Receiving Regular Insulin Added to Parenteral Nutrition vs Insulin Glargine: A Retrospective Chart Review. (Truong S, Park A, Kamalay S, Hung N, Meyer JG, Nguyen N, Momenzadeh A) Nutr Clin Pract 2019 Oct;34(5):775-782 PMID: 30693980 01/30/2019       2 Citations
  • Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. (Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B) PLoS One 2018;13(12):e0208973 PMID: 30586434 PMCID: PMC6306174 12/27/2018       15 Citations
  • Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli. (Christensen DG, Meyer JG, Baumgartner JT, D'Souza AK, Nelson WC, Payne SH, Kuhn ML, Schilling B, Wolfe AJ) mBio 2018 10 23;9(5) PMID: 30352934 PMCID: PMC6199490 10/26/2018       19 Citations
  • Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment. (Basisty N, Meyer JG, Wei L, Gibson BW, Schilling B) Proteomics 2018 09;18(17):e1800123 PMID: 30035354 PMCID: PMC6175148 07/24/2018       17 Citations
  • Quantification of Site-specific Protein Lysine Acetylation and Succinylation Stoichiometry Using Data-independent Acquisition Mass Spectrometry. (Wei L, Meyer JG, Schilling B) J Vis Exp 2018 04 04(134) PMID: 29683460 PMCID: PMC5933372 04/24/2018       4 Citations
  • The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications. (Carrico C, Meyer JG, He W, Gibson BW, Verdin E) Cell Metab 2018 03 06;27(3):497-512 PMID: 29514063 PMCID: PMC5863732 03/08/2018       82 Citations
  • Protein Turnover in Aging and Longevity. (Basisty N, Meyer JG, Schilling B) Proteomics 2018 03;18(5-6):e1700108 PMID: 29453826 PMCID: PMC6022828 02/18/2018       24 Citations
  • Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. (Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA) Nat Commun 2017 10 27;8(1):1171 PMID: 29079793 PMCID: PMC5660086 10/29/2017       40 Citations
  • PIQED: automated identification and quantification of protein modifications from DIA-MS data. (Meyer JG, Mukkamalla S, Steen H, Nesvizhskii AI, Gibson BW, Schilling B) Nat Methods 2017 06 29;14(7):646-647 PMID: 28661500 PMCID: PMC5663633 07/01/2017       23 Citations
  • Clinical applications of quantitative proteomics using targeted and untargeted data-independent acquisition techniques. (Meyer JG, Schilling B) Expert Rev Proteomics 2017 05;14(5):419-429 PMID: 28436239 PMCID: PMC5671767 04/25/2017       50 Citations
  • Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH). (Meyer JG, D'Souza AK, Sorensen DJ, Rardin MJ, Wolfe AJ, Gibson BW, Schilling B) J Am Soc Mass Spectrom 2016 11;27(11):1758-1771 PMID: 27590315 PMCID: PMC5059418 09/04/2016       40 Citations
  • Expanding proteome coverage with orthogonal-specificity α-lytic proteases. (Meyer JG, Kim S, Maltby DA, Ghassemian M, Bandeira N, Komives EA) Mol Cell Proteomics 2014 Mar;13(3):823-35 PMID: 24425750 PMCID: PMC3945911 01/16/2014       35 Citations
  • In Silico Proteome Cleavage Reveals Iterative Digestion Strategy for High Sequence Coverage. (Meyer JG) ISRN Comput Biol 2014;2014 PMID: 30687733 PMCID: PMC6347401 01/01/2014    
  • Charge state coalescence during electrospray ionization improves peptide identification by tandem mass spectrometry. (Meyer JG, A Komives E) J Am Soc Mass Spectrom 2012 Aug;23(8):1390-9 PMID: 22610994 PMCID: PMC6345509 05/23/2012       40 Citations
  • Last update: 04/02/2021