Medical College of Wisconsin
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Jing Wu PhD

Jing Wu PhD profile photo picture


Institution: Medical College of Wisconsin
Department: Physiology

Research Experience

  • Hypertension
  • Inflammation
  • Oxidative Stress
  • Renal Blood Flow, Effective
  • T-Lymphocytes
  • Vascular Remodeling
  • Vascular Stiffness
  • Vasoconstriction
  • Vasodilation
  • Methodologies and Techniques

  • Flow Cytometry
  • Juxtaglomerular Apparatus
  • Myography
  • Sodium Chloride, Dietary
  • Sympathetic Nervous System
  • Telemetry
  • Publications (34)

  • Role of the Peroxisome Proliferator Activated Receptors in Hypertension. (Fang S, Livergood MC, Nakagawa P, Wu J, Sigmund CD) Circ Res 2021 Apr 02;128(7):1021-1039 PMID: 33793338 PMCID: PMC8020861 SCOPUS ID: 2-s2.0-85103807023 04/02/2021       3 Citations
  • EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. (Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD) Hypertension 2021 04;77(4):1399-1411 PMID: 33641369 PMCID: PMC7946772 SCOPUS ID: 2-s2.0-85102907974 03/02/2021       2 Citations
  • Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores. (Klemens CA, Chulkov EG, Wu J, Hye Khan MA, Levchenko V, Flister MJ, Imig JD, Kriegel AJ, Palygin O, Staruschenko A) Hypertension 2021 02;77(2):582-593 PMID: 33390052 PMCID: PMC7856014 SCOPUS ID: 2-s2.0-85100070512 01/05/2021    
  • Cullin-3: Renal and Vascular Mechanisms Regulating Blood Pressure. (Wu J, McCormick JA, Sigmund CD) Curr Hypertens Rep 2020 08 27;22(9):61 PMID: 32852625 PMCID: PMC7477742 SCOPUS ID: 2-s2.0-85089899669 08/28/2020       2 Citations
  • Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. (Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2020 08;76(2):468-477 PMID: 32507043 PMCID: PMC7347438 SCOPUS ID: 2-s2.0-85087872461 06/09/2020       4 Citations
  • Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. (Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD) Cardiovasc Res 2021 01 01;117(1):308-319 PMID: 32428209 PMCID: PMC7797211 SCOPUS ID: 2-s2.0-85097807979 05/20/2020       9 Citations
  • The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity. (Ceddia RP, Downey JD, Morrison RD, Kraemer MP, Davis SE, Wu J, Lindsley CW, Yin H, Daniels JS, Breyer RM) Prostaglandins Other Lipid Mediat 2019 10;144:106353 PMID: 31276827 PMCID: PMC6778036 SCOPUS ID: 2-s2.0-85069842180 07/06/2019       7 Citations
  • Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension. (Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD) JCI Insight 2019 06 11;5 PMID: 31184598 PMCID: PMC6675584 SCOPUS ID: 2-s2.0-85070660042 06/12/2019       10 Citations
  • Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. (Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD) Hypertension 2019 07;74(1):173-183 PMID: 31104564 PMCID: PMC6561821 SCOPUS ID: 2-s2.0-85068196613 05/21/2019       9 Citations
  • RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity. (Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD) J Clin Invest 2019 03 21;129(6):2318-2332 PMID: 30896450 PMCID: PMC6546477 SCOPUS ID: 2-s2.0-85063644288 03/22/2019       18 Citations
  • Tumour necrosis factor α sets area postrema on fire in renovascular hypertension. (Liu J, Wu J) Cardiovasc Res 2019 05 01;115(6):995-997 PMID: 30657874 SCOPUS ID: 2-s2.0-85065934454 01/19/2019       1 Citation
  • Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. (Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD) Hypertension 2018 11;72(5):1227-1235 PMID: 30354810 PMCID: PMC6209120 SCOPUS ID: 2-s2.0-85055599374 10/26/2018       11 Citations
  • Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. (Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) JCI Insight 2018 10 04;3(19) PMID: 30282823 PMCID: PMC6237463 SCOPUS ID: 2-s2.0-85063243804 10/05/2018       28 Citations
  • A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. (Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Laroumanie F, Du L, Harrison DG, Madhur MS) JCI Insight 2017 Jul 06;2(13) PMID: 28679951 PMCID: PMC5499362 SCOPUS ID: 2-s2.0-85052537859 07/07/2017       48 Citations
  • Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle. (Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD) Hypertension 2017 07;70(1):174-182 PMID: 28507170 PMCID: PMC5472224 SCOPUS ID: 2-s2.0-85019598258 05/17/2017       16 Citations
  • Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin. (Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD) JCI Insight 2017 03 23;2(6):e91738 PMID: 28352663 PMCID: PMC5358481 SCOPUS ID: 2-s2.0-85038922808 03/30/2017       13 Citations
  • Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. (Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD) JCI Insight 2016 Nov 17;1(19):e91015 PMID: 27882355 PMCID: PMC5111503 11/25/2016    
  • Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension. (Bersi MR, Bellini C, Wu J, Montaniel KRC, Harrison DG, Humphrey JD) Hypertension 2016 May;67(5):890-896 PMID: 27001298 PMCID: PMC4833633 SCOPUS ID: 2-s2.0-84961392963 03/24/2016       61 Citations
  • CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. (Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG) Circ Res 2016 Apr 15;118(8):1233-43 PMID: 26988069 PMCID: PMC4833561 SCOPUS ID: 2-s2.0-84961393230 03/19/2016       75 Citations
  • Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension. (Mikolajczyk TP, Nosalski R, Szczepaniak P, Budzyn K, Osmenda G, Skiba D, Sagan A, Wu J, Vinh A, Marvar PJ, Guzik B, Podolec J, Drummond G, Lob HE, Harrison DG, Guzik TJ) FASEB J 2016 05;30(5):1987-99 PMID: 26873938 PMCID: PMC4836375 SCOPUS ID: 2-s2.0-84966286486 02/14/2016       115 Citations
  • Hypertension: A Disease That Strikes Around the Clock. (Wu J, Sigmund CD) Hypertension 2016 Mar;67(3):493-5 PMID: 26781274 PMCID: PMC4819989 SCOPUS ID: 2-s2.0-84958063657 01/20/2016       4 Citations
  • Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension. (Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG) Hypertension 2016 Feb;67(2):461-8 PMID: 26693821 PMCID: PMC4713264 SCOPUS ID: 2-s2.0-84954370789 12/24/2015       41 Citations
  • Immune activation caused by vascular oxidation promotes fibrosis and hypertension. (Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG) J Clin Invest 2016 Jan;126(1):50-67 PMID: 26595812 PMCID: PMC4701546 SCOPUS ID: 2-s2.0-84956708183 11/26/2015       107 Citations
  • Inhibition of JAK2 Reverses Paclitaxel Resistance in Human Ovarian Cancer Cells. (Xu Y, Zhang J, Wu J, Zhong S, Li H) Int J Gynecol Cancer 2015 Nov;25(9):1557-64 PMID: 26360705 SCOPUS ID: 2-s2.0-84946036975 09/12/2015       12 Citations
  • Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension. (Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Mernaugh RL, Chen W, Roberts J 2nd, Osborn JW, Itani HA, Harrison DG) Circ Res 2015 Aug 28;117(6):547-57 PMID: 26156232 PMCID: PMC4629828 SCOPUS ID: 2-s2.0-84940503305 07/15/2015       123 Citations
  • Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. (Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS) J Clin Invest 2015 Mar 02;125(3):1189-202 PMID: 25664851 PMCID: PMC4362266 SCOPUS ID: 2-s2.0-84924033608 02/11/2015       95 Citations
  • Oligoclonal CD8+ T cells play a critical role in the development of hypertension. (Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani H, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Harrison DG) Hypertension 2014 Nov;64(5):1108-15 PMID: 25259750 PMCID: PMC4191997 SCOPUS ID: 2-s2.0-84919714927 09/27/2014       103 Citations
  • DC isoketal-modified proteins activate T cells and promote hypertension. (Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J 2nd, Harrison DG) J Clin Invest 2014 Oct;124(10):4642-56 PMID: 25244096 PMCID: PMC4220659 SCOPUS ID: 2-s2.0-84907494957 09/23/2014       255 Citations
  • Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure. (Mai TH, Wu J, Diedrich A, Garland EM, Robertson D) J Am Soc Hypertens 2014 May;8(5):286-96 PMID: 24746612 PMCID: PMC4072204 SCOPUS ID: 2-s2.0-84901229320 04/22/2014       22 Citations
  • Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. (Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, Harrison DG) Circ Res 2014 Feb 14;114(4):616-25 PMID: 24347665 PMCID: PMC4186716 SCOPUS ID: 2-s2.0-84894499335 12/19/2013       138 Citations
  • Folic acid-coupled nano-paclitaxel liposome reverses drug resistance in SKOV3/TAX ovarian cancer cells. (Tong L, Chen W, Wu J, Li H) Anticancer Drugs 2014 Mar;25(3):244-54 PMID: 24275314 SCOPUS ID: 2-s2.0-84895075729 11/28/2013       24 Citations
  • Mineralocorticoid-receptor signalling in vascular smooth muscle. (Wu J, Luft FC) Nephrol Dial Transplant 2013 Jun;28(6):1360-2 PMID: 23439586 PMCID: PMC4007112 SCOPUS ID: 2-s2.0-84879876047 02/27/2013       1 Citation
  • [Long-term regulation of arterial pressure and essential hypertension--II. Essential hypertension]. (Fan SG, Wu J, Lv A) Sheng Li Ke Xue Jin Zhan 2007 Jan;38(1):49-57 PMID: 17438953 SCOPUS ID: 2-s2.0-84862656815 04/19/2007    
  • [Long-term regulation of arterial pressure and essential hypertension--I. Long-term regulation of arterial pressure]. (Fan SG, Wu J, Lv A) Sheng Li Ke Xue Jin Zhan 2006 Oct;37(4):339-46 PMID: 17262969 SCOPUS ID: 2-s2.0-84867655597 02/01/2007    
  • Last update: 08/12/2021