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John A. Pulikkan PhD

John A. Pulikkan PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0001-7995-6942

Member of the Cancer Center

View Curriculum Vitae

Publications (20)

  • N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia. (Peramangalam PS, Surapally S, Veltri AJ, Zheng S, Burns R, Zhu N, Rao S, Muller-Tidow C, Bushweller JH, Pulikkan JA) Sci Adv 2024 Mar;10(9):eadh8493 PMID: 38416825 PMCID: PMC10901375 SCOPUS ID: 2-s2.0-85186742316 02/28/2024    
  • Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis. (Guo M, Chan THM, Zhou Q, An O, Li Y, Song Y, Tan ZH, Ng VHE, Peramangalam PS, Tan ZQ, Cao X, Iwanaga E, Matsuoka M, Ooi MGM, Jen WY, Koh LP, Chan E, Tan LK, Goh Y, Wang W, Koh BTH, Chun CM, Fullwood MJ, Chng WJ, Osato M, Pulikkan JA, Yang H, Chen L, Tenen DG) Blood 2023 Jun 22;141(25):3078-3090 PMID: 36796022 SCOPUS ID: 2-s2.0-85160255876 02/17/2023       3 Citations
  • Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter. (van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB) Blood 2021 Oct 14;138(15):1345-1358 PMID: 34010414 PMCID: PMC8525333 SCOPUS ID: 2-s2.0-85112289640 05/20/2021       9 Citations
  • Emerging therapies for inv(16) AML. (Surapally S, Tenen DG, Pulikkan JA) Blood 2021 May 13;137(19):2579-2584 PMID: 33821975 PMCID: PMC8120144 SCOPUS ID: 2-s2.0-85105729513 04/07/2021       10 Citations
  • DOT1L inhibitors block abnormal self-renewal induced by cohesin loss. (Heimbruch KE, Fisher JB, Stelloh CT, Phillips E, Reimer MH Jr, Wargolet AJ, Meyer AE, Pulakanti K, Viny AD, Loppnow JJ, Levine RL, Pulikkan JA, Zhu N, Rao S) Sci Rep 2021 Mar 31;11(1):7288 PMID: 33790356 PMCID: PMC8012605 SCOPUS ID: 2-s2.0-85103745135 04/02/2021       7 Citations
  • CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. (Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH) Cell 2018 Jun 28;174(1):172-186.e21 PMID: 29958106 PMCID: PMC6211564 SCOPUS ID: 2-s2.0-85048726457 06/30/2018       52 Citations
  • Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia. (Pulikkan JA, Castilla LH) Front Oncol 2018;8:129 PMID: 29755956 PMCID: PMC5932169 SCOPUS ID: 2-s2.0-85046097498 05/15/2018       12 Citations
  • Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131]. (Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH) EBioMedicine 2017 Nov;25:188 PMID: 29104075 PMCID: PMC5704058 SCOPUS ID: 2-s2.0-85032895074 11/07/2017    
  • RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia. (Choi A, Illendula A, Pulikkan JA, Roderick JE, Tesell J, Yu J, Hermance N, Zhu LJ, Castilla LH, Bushweller JH, Kelliher MA) Blood 2017 Oct 12;130(15):1722-1733 PMID: 28790107 PMCID: PMC5639483 SCOPUS ID: 2-s2.0-85031292142 08/10/2017       53 Citations
  • C/EBPα deregulation as a paradigm for leukemogenesis. (Pulikkan JA, Tenen DG, Behre G) Leukemia 2017 Nov;31(11):2279-2285 PMID: 28720765 PMCID: PMC8197657 SCOPUS ID: 2-s2.0-85032623277 07/20/2017       50 Citations
  • Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. (Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH) EBioMedicine 2016 Jun;8:117-131 PMID: 27428424 PMCID: PMC4919611 SCOPUS ID: 2-s2.0-84966769195 07/20/2016       72 Citations
  • Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. (Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH) Science 2015 Feb 13;347(6223):779-84 PMID: 25678665 PMCID: PMC4423805 SCOPUS ID: 2-s2.0-84922949970 02/14/2015       94 Citations
  • NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis. (Xue L, Pulikkan JA, Valk PJ, Castilla LH) Blood 2014 Jul 17;124(3):426-36 PMID: 24894773 PMCID: PMC4102713 SCOPUS ID: 2-s2.0-84904479774 06/05/2014       22 Citations
  • Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. (Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH) Blood 2012 Jul 26;120(4):868-79 PMID: 22613795 PMCID: PMC3412349 SCOPUS ID: 2-s2.0-84864484317 05/23/2012       44 Citations
  • C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. (Pulikkan JA, Peramangalam PS, Dengler V, Ho PA, Preudhomme C, Meshinchi S, Christopeit M, Nibourel O, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G) Blood 2010 Dec 16;116(25):5638-49 PMID: 20889924 PMCID: PMC3031410 SCOPUS ID: 2-s2.0-78650459322 10/05/2010       122 Citations
  • Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. (Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G) Leukemia 2010 May;24(5):914-23 PMID: 20376080 PMCID: PMC2923485 SCOPUS ID: 2-s2.0-77952423398 04/09/2010       47 Citations
  • Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. (Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G) Blood 2010 Mar 04;115(9):1768-78 PMID: 20029046 PMCID: PMC2832809 SCOPUS ID: 2-s2.0-77950354353 12/24/2009       251 Citations
  • Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9. (Geletu M, Balkhi MY, Peer Zada AA, Christopeit M, Pulikkan JA, Trivedi AK, Tenen DG, Behre G) Blood 2007 Nov 01;110(9):3301-9 PMID: 17671234 SCOPUS ID: 2-s2.0-36148968960 08/03/2007       64 Citations
  • Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. (Zada AA, Pulikkan JA, Bararia D, Geletu M, Trivedi AK, Balkhi MY, Hiddemann WD, Tenen DG, Behre HM, Behre G) Leukemia 2006 Dec;20(12):2137-46 PMID: 17082780 SCOPUS ID: 2-s2.0-33751235604 11/04/2006       27 Citations
  • Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63. (Zada AA, Geletu MH, Pulikkan JA, Müller-Tidow C, Reddy VA, Christopeit M, Hiddemann WD, Behre HM, Tenen DG, Behre G) Proteomics 2006 Nov;6(21):5705-19 PMID: 17001604 SCOPUS ID: 2-s2.0-33751110210 09/27/2006       14 Citations
    • Last update: 02/29/2024