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John A. Pulikkan PhD

John A. Pulikkan PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center


Publications (15)

  • CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. (Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH) Cell 2018 06 28;174(1):172-186.e21 PMID: 29958106 PMCID: PMC6211564 06/30/2018       17 Citations
  • Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia. (Pulikkan JA, Castilla LH) Front Oncol 2018;8:129 PMID: 29755956 PMCID: PMC5932169 05/15/2018    
  • Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131]. (Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH) EBioMedicine 2017 11;25:188 PMID: 29104075 PMCID: PMC5704058 11/07/2017    
  • RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia. (Choi A, Illendula A, Pulikkan JA, Roderick JE, Tesell J, Yu J, Hermance N, Zhu LJ, Castilla LH, Bushweller JH, Kelliher MA) Blood 2017 10 12;130(15):1722-1733 PMID: 28790107 PMCID: PMC5639483 08/10/2017       21 Citations
  • C/EBPα deregulation as a paradigm for leukemogenesis. (Pulikkan JA, Tenen DG, Behre G) Leukemia 2017 11;31(11):2279-2285 PMID: 28720765 07/20/2017       22 Citations
  • Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. (Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH) EBioMedicine 2016 Jun;8:117-131 PMID: 27428424 PMCID: PMC4919611 07/20/2016       35 Citations
  • Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. (Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH) Science 2015 Feb 13;347(6223):779-84 PMID: 25678665 PMCID: PMC4423805 02/14/2015       58 Citations
  • NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis. (Xue L, Pulikkan JA, Valk PJ, Castilla LH) Blood 2014 Jul 17;124(3):426-36 PMID: 24894773 PMCID: PMC4102713 06/05/2014       16 Citations
  • Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. (Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH) Blood 2012 Jul 26;120(4):868-79 PMID: 22613795 PMCID: PMC3412349 05/23/2012       38 Citations
  • C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. (Pulikkan JA, Peramangalam PS, Dengler V, Ho PA, Preudhomme C, Meshinchi S, Christopeit M, Nibourel O, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G) Blood 2010 Dec 16;116(25):5638-49 PMID: 20889924 PMCID: PMC3031410 10/05/2010       99 Citations
  • Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. (Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G) Leukemia 2010 May;24(5):914-23 PMID: 20376080 PMCID: PMC2923485 04/09/2010    
  • Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. (Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G) Blood 2010 Mar 04;115(9):1768-78 PMID: 20029046 PMCID: PMC2832809 12/24/2009       213 Citations
  • Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9. (Geletu M, Balkhi MY, Peer Zada AA, Christopeit M, Pulikkan JA, Trivedi AK, Tenen DG, Behre G) Blood 2007 Nov 01;110(9):3301-9 PMID: 17671234 08/03/2007       57 Citations
  • Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. (Zada AA, Pulikkan JA, Bararia D, Geletu M, Trivedi AK, Balkhi MY, Hiddemann WD, Tenen DG, Behre HM, Behre G) Leukemia 2006 Dec;20(12):2137-46 PMID: 17082780 11/04/2006       26 Citations
  • Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63. (Zada AA, Geletu MH, Pulikkan JA, Müller-Tidow C, Reddy VA, Christopeit M, Hiddemann WD, Behre HM, Tenen DG, Behre G) Proteomics 2006 Nov;6(21):5705-19 PMID: 17001604 09/27/2006       11 Citations
  • Last update: 02/13/2020
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