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John D. Imig PhD

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

image of /images/ORCIDiD_icon16x16.png https://orcid.org/0000-0002-9668-2899

Member of the Cancer Center
Member of the Cardiovascular Center

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Publications (249)

Epoxylipids and soluble epoxide hydrolase in heart diseases (Imig JD, Cervenka L, Neckar J) Biochemical Pharmacology January 2022;195 SCOPUS ID: 2-s2.0-85120733144 01/01/2022

Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity (Jankiewicz WK, Barnett SD, Stavniichuk A, Hwang SH, Hammock BD, Belayet JB, Khan AH, Imig JD) Frontiers in Pharmacology 9 December 2021;12 SCOPUS ID: 2-s2.0-85121640330 12/09/2021

Kidney in the net of acute and long-haul coronavirus disease 2019: a potential role for lipid mediators in causing renal injury and fibrosis. (Chiang KC, Imig JD, Kalantar-Zadeh K, Gupta A) Curr Opin Nephrol Hypertens 2022 01 01;31(1):36-46 PMID: 34846312 SCOPUS ID: 2-s2.0-85122348632 12/01/2021

Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes. (Widiapradja A, Kasparian AO, McCaffrey SL, Kolb LL, Imig JD, Lacey JL, Melendez GC, Levick SP) Cells 2021 10 05;10(10) PMID: 34685639 PMCID: PMC8534147 SCOPUS ID: 2-s2.0-85116337891 10/24/2021

Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice. (George J, Zhang Y, Sloan J, Sims JM, Imig JD, Zhao X) Front Immunol 2021;12:747794 PMID: 34675931 PMCID: PMC8523998 SCOPUS ID: 2-s2.0-85117452647 10/23/2021

Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation. (Kala P, Miklovič M, Jíchová Š, Škaroupková P, Vaňourková Z, Maxová H, Gawrys O, Kompanowska-Jezierska E, Sadowski J, Imig JD, Falck JR, Veselka J, Červenka L, Aiglová R, Vícha M, Gloger V, Táborský M) Biomedicines 2021 Aug 20;9(8) PMID: 34440257 PMCID: PMC8393645 SCOPUS ID: 2-s2.0-85113666016 08/28/2021 2 Citations

Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats. (Khan MAH, Hwang SH, Barnett SD, Stavniichuk A, Jankiewicz WK, Hammock BD, Imig JD) Br J Pharmacol 2021 11;178(22):4468-4484 PMID: 34255857 SCOPUS ID: 2-s2.0-85112337678 07/14/2021 1 Citation

Diabetes risk associated with plasma epoxylipid levels. (Imig JD) EBioMedicine 2021 04;66:103331 PMID: 33857907 PMCID: PMC8050865 SCOPUS ID: 2-s2.0-85104061350 04/16/2021

Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity. (Imig JD, Hye Khan MA, Burkhan A, Chen G, Adebesin AM, Falck JR) Int J Mol Sci 2021 Mar 10;22(6) PMID: 33801911 PMCID: PMC7998941 SCOPUS ID: 2-s2.0-85103862451 04/04/2021 2 Citations

Diabetes risk associated with plasma epoxylipid levels (Imig JD) EBioMedicine April 2021;66 SCOPUS ID: 2-s2.0-85104061350 04/01/2021

Multi-Target Approaches in Metabolic Syndrome. (Lillich FF, Imig JD, Proschak E) Front Pharmacol 2020;11:554961 PMID: 33776749 PMCID: PMC7994619 SCOPUS ID: 2-s2.0-85103326693 03/30/2021 7 Citations

Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats. (Walkowska A, Červenka L, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E) Front Physiol 2021;12:622882 PMID: 33584348 PMCID: PMC7876274 SCOPUS ID: 2-s2.0-85100769778 02/16/2021 1 Citation

THE EFFECT OF COMPOUND DM509 ON KIDNEY FIBROSIS IN THE CONDITIONS OF THE EXPERIMENTAL MODEL. (Stavniichuk A, Savchuk O, Khan AH, Jankiewicz WK, Imig JD, Merk D) Visnyk Kyivskoho Natsionalnoho Universytetu Imeni Tarasa Shevchenka Biolohiia 2020;80(1):10-15 PMID: 33437972 PMCID: PMC7799440 01/14/2021

Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores. (Klemens CA, Chulkov EG, Wu J, Hye Khan MA, Levchenko V, Flister MJ, Imig JD, Kriegel AJ, Palygin O, Staruschenko A) Hypertension 2021 02;77(2):582-593 PMID: 33390052 PMCID: PMC7856014 SCOPUS ID: 2-s2.0-85100070512 01/05/2021

Editorial: Renal Function in Acute and Chronic Kidney Diseases. (Imig JD, Hye Khan MA, Zhao X) Front Physiol 2020;11:625353 PMID: 33343402 PMCID: PMC7744816 SCOPUS ID: 2-s2.0-85097813392 12/22/2020

A SORAFENIB INDUCED MODEL OF GLOMERULAR KIDNEY DISEASE. (Stavniichuk A, Savchuk O, Khan AH, Jankiewicz WK, Imig JD) Visnyk Kyivskoho Natsionalnoho Universytetu Imeni Tarasa Shevchenka Biolohiia 2020;81(2):25-31 PMID: 33251532 PMCID: PMC7696638 12/01/2020

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. (Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT) Cancers (Basel) 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020 1 Citation

Eicosanoid blood vessel regulation in physiological and pathological states. (Imig JD) Clin Sci (Lond) 2020 10 30;134(20):2707-2727 PMID: 33095237 SCOPUS ID: 2-s2.0-85094684789 10/24/2020 6 Citations

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors. (Imig JD, Morisseau C) Front Pharmacol 2020;11:598858 PMID: 33071800 PMCID: PMC7544929 SCOPUS ID: 2-s2.0-85092135063 10/20/2020 1 Citation

Dual soluble epoxide hydrolase inhibitor/PPAR-γ agonist attenuates renal fibrosis. (Stavniichuk A, Hye Khan MA, Yeboah MM, Chesnik MA, Jankiewicz WK, Hartmann M, Blöcher R, Kircher T, Savchuk O, Proschak E, Imig JD) Prostaglandins Other Lipid Mediat 2020 10;150:106472 PMID: 32569747 SCOPUS ID: 2-s2.0-85086773315 06/23/2020 4 Citations

Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture. (Imig JD, Jankiewicz WK, Khan AH) Hypertension 2020 07;76(1):3-15 PMID: 32475311 PMCID: PMC7448548 SCOPUS ID: 2-s2.0-85086345972 06/02/2020 7 Citations

Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (Gawrys O, Husková Z, Baranowska I, Walkowska A, Sadowski J, Kikerlová S, Vaňourková Z, Honetschlägerová Z, Škaroupková P, Červenka L, Falck JR, Imig JD, Kompanowska-Jezierska E) J Hypertens 2020 09;38(9):1802-1810 PMID: 32384390 SCOPUS ID: 2-s2.0-85089302292 05/10/2020 6 Citations

Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats. (Čertíková Chábová V, Kujal P, Vaňourková Z, Škaroupková P, Sadowski J, Kompanowska-Jezierska E, Tesař V, Hammock B, Imig J, Maxová H, Červenka L, Vaněčková I) Kidney Blood Press Res 2019;44(6):1493-1505 PMID: 31770762 SCOPUS ID: 2-s2.0-85075787703 11/27/2019 2 Citations

Epoxyeicosanoids in hypertension. (Imig JD) Physiol Res 2019 10 25;68(5):695-704 PMID: 31475560 PMCID: PMC6941753 SCOPUS ID: 2-s2.0-85074674063 09/03/2019 13 Citations

Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure. (Vacková Š, Kikerlová S, Melenovsky V, Kolář F, Imig JD, Kompanowska-Jezierska E, Sadowski J, Červenka L) Kidney Blood Press Res 2019;44(4):792-809 PMID: 31430751 SCOPUS ID: 2-s2.0-85071709898 08/21/2019 8 Citations

Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart. (Widiapradja A, Manteufel EJ, Dehlin HM, Pena J, Goldspink PH, Sharma A, Kolb LL, Imig JD, Janicki JS, Lu B, Levick SP) Sci Rep 2019 07 29;9(1):11004 PMID: 31358823 PMCID: PMC6662794 SCOPUS ID: 2-s2.0-85069892832 07/31/2019 8 Citations

Epoxyeicosatrienoic Acid Analog EET-A Blunts Development of Lupus Nephritis in Mice. (Hye Khan MA, Stavniichuk A, Sattar MA, Falck JR, Imig JD) Front Pharmacol 2019;10:512 PMID: 31133860 PMCID: PMC6523399 SCOPUS ID: 2-s2.0-85068851851 05/28/2019 7 Citations

A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice. (Hye Khan MA, Schmidt J, Stavniichuk A, Imig JD, Merk D) Biochem Pharmacol 2019 08;166:212-221 PMID: 31129048 PMCID: PMC6939295 SCOPUS ID: 2-s2.0-85066443159 05/28/2019 12 Citations

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (Neckář J, Hye Khan MA, Gross GJ, Cyprová M, Hrdlička J, Kvasilová A, Falck JR, Campbell WB, Sedláková L, Škutová Š, Olejníčková V, Gregorovičová M, Sedmera D, Kolář F, Imig JD) Clin Sci (Lond) 2019 04 30;133(8):939-951 PMID: 30979784 PMCID: PMC6492034 SCOPUS ID: 2-s2.0-85064975365 04/14/2019 8 Citations

Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats. (Hrdlička J, Neckář J, Papoušek F, Husková Z, Kikerlová S, Vaňourková Z, Vernerová Z, Akat F, Vašinová J, Hammock BD, Hwang SH, Imig JD, Falck JR, Červenka L, Kolář F) Front Pharmacol 2019;10:159 PMID: 30881303 PMCID: PMC6406051 SCOPUS ID: 2-s2.0-85064975290 03/19/2019 8 Citations

Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats. (Vacková Š, Kopkan L, Kikerlová S, Husková Z, Sadowski J, Kompanowska-Jezierska E, Hammock BD, Imig JD, Táborský M, Melenovský V, Červenka L) Front Pharmacol 2019;10:18 PMID: 30728778 PMCID: PMC6351500 SCOPUS ID: 2-s2.0-85064985153 02/08/2019 6 Citations

Epigenetic soluble epoxide hydrolase regulation causes endothelial dysfunction. (Imig JD) Acta Physiol (Oxf) 2019 01;225(1):e13203 PMID: 30307705 PMCID: PMC6548442 SCOPUS ID: 2-s2.0-85055569922 10/12/2018 2 Citations

Inactivation of p66Shc Decreases Afferent Arteriolar K_ATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats. (Miller BS, Blumenthal SR, Shalygin A, Wright KD, Staruschenko A, Imig JD, Sorokin A) Diabetes 2018 11;67(11):2206-2212 PMID: 30131395 PMCID: PMC6198347 SCOPUS ID: 2-s2.0-85055169170 08/23/2018 7 Citations

Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3. (Neckář J, Hsu A, Hye Khan MA, Gross GJ, Nithipatikom K, Cyprová M, Benák D, Hlaváčková M, Sotáková-Kašparová D, Falck JR, Sedmera D, Kolář F, Imig JD) Am J Physiol Heart Circ Physiol 2018 11 01;315(5):H1148-H1158 PMID: 30074840 PMCID: PMC6734065 SCOPUS ID: 2-s2.0-85054889895 08/04/2018 13 Citations

20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats. (Sedláková L, Kikerlová S, Husková Z, Červenková L, Chábová VČ, Zicha J, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Krátký V, Červenka L, Kopkan L) Biosci Rep 2018 10 31;38(5) PMID: 30054426 PMCID: PMC6131326 SCOPUS ID: 2-s2.0-85053116578 07/29/2018 5 Citations

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes. (Hye Khan MA, Kolb L, Skibba M, Hartmann M, Blöcher R, Proschak E, Imig JD) Diabetologia 2018 10;61(10):2235-2246 PMID: 30032428 PMCID: PMC6563928 SCOPUS ID: 2-s2.0-85050303281 07/23/2018 25 Citations

Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics. (Imig JD) Pharmacol Ther 2018 12;192:1-19 PMID: 29964123 PMCID: PMC6263841 SCOPUS ID: 2-s2.0-85049305095 07/03/2018 36 Citations

Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. (Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J) J Hypertens 2018 06;36(6):1326-1341 PMID: 29570510 PMCID: PMC7375140 SCOPUS ID: 2-s2.0-85046619324 03/24/2018 21 Citations

Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. (Čertíková Chábová V, Kujal P, Škaroupková P, Varňourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesař V, Červenka L) Kidney Blood Press Res 2018;43(2):329-349 PMID: 29529602 PMCID: PMC5985203 SCOPUS ID: 2-s2.0-85050997694 03/13/2018 9 Citations

Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula. (Kala P, Sedláková L, Škaroupková P, Kopkan L, Vaňourková Z, Táborský M, Nishiyama A, Hwang SH, Hammock BD, Sadowski J, Melenovský V, Imig JD, Červenka L) Physiol Res 2018 07 17;67(3):401-415 PMID: 29527914 PMCID: PMC6056335 SCOPUS ID: 2-s2.0-85050353397 03/13/2018 12 Citations

Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis. (Yeboah MM, Hye Khan MA, Chesnik MA, Skibba M, Kolb LL, Imig JD) Nephrol Dial Transplant 2018 08 01;33(8):1333-1343 PMID: 29361048 PMCID: PMC6070028 SCOPUS ID: 2-s2.0-85054993146 01/24/2018 6 Citations

Orally Active Epoxyeicosatrienoic Acid Analogs. (Campbell WB, Imig JD, Schmitz JM, Falck JR) J Cardiovasc Pharmacol 2017 Oct;70(4):211-224 PMID: 28937442 PMCID: PMC5673125 SCOPUS ID: 2-s2.0-85032230771 09/25/2017 21 Citations

Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. (Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG) Biochim Biophys Acta Gen Subj 2017 Nov;1861(11 Pt A):2758-2765 PMID: 28757338 PMCID: PMC5873293 SCOPUS ID: 2-s2.0-85026839067 08/02/2017 16 Citations

Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition. (Skibba M, Hye Khan MA, Kolb LL, Yeboah MM, Falck JR, Amaradhi R, Imig JD) Front Pharmacol 2017;8:406 PMID: 28713267 PMCID: PMC5491687 SCOPUS ID: 2-s2.0-85021686897 07/18/2017 23 Citations

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. (Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM) Diabetologia 2017 06;60(6):1066-1075 PMID: 28352940 PMCID: PMC5921930 SCOPUS ID: 2-s2.0-85016108070 03/30/2017 22 Citations

Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function. (Imig JD) Adv Pharmacol 2016;77:105-41 PMID: 27451096 PMCID: PMC5510644 SCOPUS ID: 2-s2.0-84964823830 07/28/2016 50 Citations

A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat. (Hye Khan MA, Hwang SH, Sharma A, Corbett JA, Hammock BD, Imig JD) Prostaglandins Other Lipid Mediat 2016 09;125:40-7 PMID: 27432695 PMCID: PMC5035206 SCOPUS ID: 2-s2.0-84979211632 07/20/2016 27 Citations

Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. (Jíchová Š, Kopkan L, Husková Z, Doleželová Š, Neckář J, Kujal P, Vernerová Z, Kramer HJ, Sadowski J, Kompanowska-Jezierska E, Reddy RN, Falck JR, Imig JD, Červenka L) J Hypertens 2016 10;34(10):2008-25 PMID: 27428043 PMCID: PMC5510029 SCOPUS ID: 2-s2.0-84978658313 07/19/2016 16 Citations

The epoxyeicosatrienoic acid analog PVPA ameliorates cyclosporine-induced hypertension and renal injury in rats. (Yeboah MM, Hye Khan MA, Chesnik MA, Sharma A, Paudyal MP, Falck JR, Imig JD) Am J Physiol Renal Physiol 2016 09 01;311(3):F576-85 PMID: 27358055 PMCID: PMC5504406 SCOPUS ID: 2-s2.0-84986203453 07/01/2016 13 Citations

p66Shc regulates renal vascular tone in hypertension-induced nephropathy. (Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A) J Clin Invest 2016 07 01;126(7):2533-46 PMID: 27270176 PMCID: PMC4922697 SCOPUS ID: 2-s2.0-84978419542 06/09/2016 23 Citations

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. (Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD) Int J Mol Sci 2016 May 18;17(5) PMID: 27213332 PMCID: PMC4881572 SCOPUS ID: 2-s2.0-84969143046 05/24/2016 18 Citations

Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. (Sporková A, Reddy RN, Falck JR, Imig JD, Kopkan L, Sadowski J, Červenka L) Am J Med Sci 2016 05;351(5):513-9 PMID: 27140711 PMCID: PMC5021442 SCOPUS ID: 2-s2.0-84970969156 05/04/2016 5 Citations

Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites. (Imig JD, Hye Khan MA, Sharma A, Fish BL, Mandel NS, Cohen EP) Am J Physiol Heart Circ Physiol 2016 06 01;310(11):H1695-701 PMID: 27106038 PMCID: PMC4935507 SCOPUS ID: 2-s2.0-84983739117 04/24/2016 2 Citations

Renal blood flow autoregulation: what are the contributions for nitric oxide or superoxide to modulate the myogenic response? (Imig JD) Am J Physiol Renal Physiol 2016 05 15;310(10):F1013-5 PMID: 26962100 PMCID: PMC5002057 SCOPUS ID: 2-s2.0-84984598069 03/11/2016

Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy. (Hye Khan MA, Fish B, Wahl G, Sharma A, Falck JR, Paudyal MP, Moulder JE, Imig JD, Cohen EP) Clin Sci (Lond) 2016 Apr;130(8):587-99 PMID: 26772189 PMCID: PMC5020909 SCOPUS ID: 2-s2.0-84973535605 01/17/2016 20 Citations

Cytochrome P450 and Lipoxygenase Metabolites on Renal Function. (Imig JD, Khan MA) Compr Physiol 2015 Dec 15;6(1):423-41 PMID: 26756638 PMCID: PMC5965260 SCOPUS ID: 2-s2.0-85016150258 01/13/2016 13 Citations

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. (Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD) PLoS One 2015;10(12):e0145335 PMID: 26683993 PMCID: PMC4686180 SCOPUS ID: 2-s2.0-84956951131 12/20/2015 1 Citation

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 SCOPUS ID: 2-s2.0-84947616348 09/20/2015 7 Citations

Reply to "Letter to the editor: 'Concern regarding quantification of urinary nephrin by commercially available ELISA'". (Sullivan JC, Imig JD) Am J Physiol Renal Physiol 2015 Aug 01;309(3):F271 PMID: 26357487 SCOPUS ID: 2-s2.0-84938583004 09/12/2015

Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats. (Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L) Vascul Pharmacol 2015 Oct;73:45-56 PMID: 26304700 SCOPUS ID: 2-s2.0-84941741068 08/26/2015 10 Citations

Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. (Červenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, Hwang SH, Hammock BD, Imig JD, Sadowski J) Physiol Res 2015;64(6):857-73 PMID: 26047375 PMCID: PMC4984848 SCOPUS ID: 2-s2.0-84983099949 06/06/2015 20 Citations

Tumour necrosis factor-α contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia. (Chytilová A, Borchert GH, Mandíková-Alánová P, Hlaváčková M, Kopkan L, Khan MA, Imig JD, Kolář F, Neckář J) Acta Physiol (Oxf) 2015 May;214(1):97-108 PMID: 25760892 SCOPUS ID: 2-s2.0-84927615290 03/12/2015 19 Citations

Epoxyeicosatrienoic acids, hypertension, and kidney injury. (Imig JD) Hypertension 2015 Mar;65(3):476-82 PMID: 25583156 PMCID: PMC4326585 SCOPUS ID: 2-s2.0-84924237583 01/15/2015 55 Citations

Erratum: 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates: Carboxylate modifications (Journal of Medicinal Chemistry (2014) 57 (6965-6972) DOI: 10.1021/jm500262m) (Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB) Journal of Medicinal Chemistry 13 November 2014;57(21):9218 SCOPUS ID: 2-s2.0-84923793795 11/13/2014 2 Citations

Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. (Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ) Am J Physiol Renal Physiol 2015 Jan 15;308(2):F131-9 PMID: 25377915 PMCID: PMC4338924 SCOPUS ID: 2-s2.0-84921000088 11/08/2014 44 Citations

Correction to 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications. (Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB) J Med Chem 2014 Nov 13;57(21):9218 PMID: 25369142 PMCID: PMC4234425 11/05/2014

WX-III-287-19 A Possible Thromboxane Antagonist in Bovine Coronary Arteries. (Shah AJ, Gauthier KM, Imig JD, Falck JR, Campbell WB) Value Health 2014 Nov;17(7):A732-3 PMID: 27202619 11/01/2014

Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury. (Khan AH, Falck JR, Manthati VL, Campbell WB, Imig JD) Front Pharmacol 2014;5:216 PMID: 25295006 PMCID: PMC4172029 SCOPUS ID: 2-s2.0-84907097656 10/09/2014 28 Citations

Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. (Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L) Clin Exp Pharmacol Physiol 2014 Dec;41(12):1003-13 PMID: 25224811 PMCID: PMC4347520 SCOPUS ID: 2-s2.0-84912527315 09/17/2014 15 Citations

Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. (Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ) Am J Physiol Renal Physiol 2014 Oct 15;307(8):F971-80 PMID: 25164080 PMCID: PMC4200297 SCOPUS ID: 2-s2.0-84908061327 08/29/2014 62 Citations

14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. (Falck JR, Koduru SR, Mohapatra S, Manne R, Atcha KR, Atcha R, Manthati VL, Capdevila JH, Christian S, Imig JD, Campbell WB) J Med Chem 2014 Aug 28;57(16):6965-72 PMID: 25119815 PMCID: PMC4148164 SCOPUS ID: 2-s2.0-84906871712 08/15/2014 22 Citations

Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. (Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A) J Am Soc Nephrol 2015 Mar;26(3):597-610 PMID: 25071086 PMCID: PMC4341468 SCOPUS ID: 2-s2.0-84924052484 07/30/2014 29 Citations

Azilsartan decreases renal and cardiovascular injury in the spontaneously hypertensive obese rat. (Hye Khan MA, Neckář J, Cummens B, Wahl GM, Imig JD) Cardiovasc Drugs Ther 2014 Aug;28(4):313-22 PMID: 24842561 SCOPUS ID: 2-s2.0-84927170630 05/21/2014 20 Citations

Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition. (Hye Khan MA, Pavlov TS, Christain SV, Neckář J, Staruschenko A, Gauthier KM, Capdevila JH, Falck JR, Campbell WB, Imig JD) Clin Sci (Lond) 2014 Oct;127(7):463-74 PMID: 24707975 PMCID: PMC4167712 SCOPUS ID: 2-s2.0-84903999535 04/09/2014 48 Citations

Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats. (Hye Khan MA, Neckář J, Haines J, Imig JD) Am J Hypertens 2014 Aug;27(8):1087-95 PMID: 24598210 SCOPUS ID: 2-s2.0-84905824093 03/07/2014 14 Citations

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. (Kujal P, Čertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Červenka L) Clin Exp Pharmacol Physiol 2014 Mar;41(3):227-37 PMID: 24471737 PMCID: PMC4038339 SCOPUS ID: 2-s2.0-84896322811 01/30/2014 32 Citations

Fructose stimulates Na/H exchange activity and sensitizes the proximal tubule to angiotensin II. (Cabral PD, Hong NJ, Hye Khan MA, Ortiz PA, Beierwaltes WH, Imig JD, Garvin JL) Hypertension 2014 Mar;63(3):e68-73 PMID: 24379189 SCOPUS ID: 2-s2.0-84894487159 01/01/2014 49 Citations

The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. (Capdevila JH, Pidkovka N, Mei S, Gong Y, Falck JR, Imig JD, Harris RC, Wang W) J Biol Chem 2014 Feb 14;289(7):4377-86 PMID: 24368771 PMCID: PMC3924300 SCOPUS ID: 2-s2.0-84894174832 12/26/2013 42 Citations

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet. (Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, El-Remessy AB) Diabetologia 2014 Feb;57(2):413-23 PMID: 24201577 PMCID: PMC3947289 SCOPUS ID: 2-s2.0-84893663061 11/10/2013 95 Citations

Afferent Arteriolar Responses to β,γ-methylene ATP and 20-HETE are not Blocked by ENaC Inhibition. (Nagasawa T, Imig JD) Physiol Rep 2013 Sep 01;1(4):e00082 PMID: 24159379 PMCID: PMC3804346 10/26/2013

Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat. (Hye Khan MA, Neckár J, Manthati V, Errabelli R, Pavlov TS, Staruschenko A, Falck JR, Imig JD) Hypertension 2013 Nov;62(5):905-13 PMID: 23980070 PMCID: PMC3872985 SCOPUS ID: 2-s2.0-84886393761 08/28/2013 46 Citations

Immune and inflammatory role in renal disease. (Imig JD, Ryan MJ) Compr Physiol 2013 Apr;3(2):957-76 PMID: 23720336 PMCID: PMC3803162 SCOPUS ID: 2-s2.0-84879313137 05/31/2013 178 Citations

Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. (Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD) J Cardiovasc Pharmacol 2013 Sep;62(3):285-97 PMID: 23676336 PMCID: PMC3773051 SCOPUS ID: 2-s2.0-84884671223 05/17/2013 71 Citations

Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity. (Khan MA, Liu J, Kumar G, Skapek SX, Falck JR, Imig JD) FASEB J 2013 Aug;27(8):2946-56 PMID: 23603837 PMCID: PMC3714587 SCOPUS ID: 2-s2.0-84881128520 04/23/2013 56 Citations

Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor γ agonist improve vascular function and decrease renal injury in hypertensive obese rats. (Imig JD, Walsh KA, Hye Khan MA, Nagasawa T, Cherian-Shaw M, Shaw SM, Hammock BD) Exp Biol Med (Maywood) 2012 Dec;237(12):1402-12 PMID: 23354399 PMCID: PMC3613242 SCOPUS ID: 2-s2.0-84873045242 01/29/2013 50 Citations

Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function. (Imig JD) Prostaglandins Other Lipid Mediat 2013 Jul-Aug;104-105:2-7 PMID: 23333581 PMCID: PMC3664103 SCOPUS ID: 2-s2.0-84879685602 01/22/2013 52 Citations

Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME. (Honetschlägerová Z, Kitada K, Husková Z, Sporková A, Kopkan L, Bürgelová M, Varcabová Š, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Červenka L) J Hypertens 2013 Feb;31(2):321-32 PMID: 23307303 PMCID: PMC3773167 SCOPUS ID: 2-s2.0-84872851462 01/12/2013 18 Citations

Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system. (Varcabova S, Huskova Z, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Kitada K, Cervenka L) Clin Exp Pharmacol Physiol 2013 Apr;40(4):273-81 PMID: 23039246 PMCID: PMC3769696 SCOPUS ID: 2-s2.0-84875652885 10/09/2012 16 Citations

Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension. (Kopkan L, Husková Z, Sporková A, Varcabová Š, Honetschlägerová Z, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Kramer HJ, Bürgelová M, Vojtíšková A, Kujal P, Vernerová Z, Červenka L) Kidney Blood Press Res 2012;35(6):595-607 PMID: 22948718 PMCID: PMC3604982 SCOPUS ID: 2-s2.0-84865607664 09/06/2012 23 Citations

Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib. (Nagasawa T, Hye Khan MA, Imig JD) Clin Exp Pharmacol Physiol 2012 May;39(5):454-61 PMID: 22443474 PMCID: PMC3613249 SCOPUS ID: 2-s2.0-84860226420 03/27/2012 18 Citations

Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension. (Neckář J, Kopkan L, Husková Z, Kolář F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Ošťádal B, Červenka L) Clin Sci (Lond) 2012 Jun;122(11):513-25 PMID: 22324471 PMCID: PMC3528350 SCOPUS ID: 2-s2.0-84860233421 02/14/2012 52 Citations

11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries. (Bukhari IA, Shah AJ, Gauthier KM, Walsh KA, Koduru SR, Imig JD, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2012 Apr 15;302(8):H1574-83 PMID: 22307677 PMCID: PMC3330801 SCOPUS ID: 2-s2.0-84859739269 02/07/2012 18 Citations

Epoxides and soluble epoxide hydrolase in cardiovascular physiology. (Imig JD) Physiol Rev 2012 Jan;92(1):101-30 PMID: 22298653 PMCID: PMC3613253 SCOPUS ID: 2-s2.0-84856747668 02/03/2012 254 Citations

Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. (Elmarakby AA, Faulkner J, Al-Shabrawey M, Wang MH, Maddipati KR, Imig JD) Am J Physiol Regul Integr Comp Physiol 2011 Nov;301(5):R1307-17 PMID: 21832210 PMCID: PMC3213948 SCOPUS ID: 2-s2.0-80155165329 08/13/2011 67 Citations

Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy. (Zhao X, Zhang Y, Li L, Mann D, Imig JD, Emmett N, Gibbons G, Jin LM) Am J Nephrol 2011;34(3):268-80 PMID: 21822010 PMCID: PMC3169370 SCOPUS ID: 2-s2.0-79961115589 08/09/2011 36 Citations

Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. (Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Falck JR, Campbell WB) Am J Physiol Renal Physiol 2011 Oct;301(4):F765-72 PMID: 21753077 PMCID: PMC3191800 SCOPUS ID: 2-s2.0-80053364499 07/15/2011 4 Citations

Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. (Honetschlägerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Chábová VC, Tesař V, Cervenka L) J Hypertens 2011 Aug;29(8):1590-601 PMID: 21720266 PMCID: PMC3777565 SCOPUS ID: 2-s2.0-79960596181 07/02/2011 30 Citations

Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. (Luria A, Bettaieb A, Xi Y, Shieh GJ, Liu HC, Inoue H, Tsai HJ, Imig JD, Haj FG, Hammock BD) Proc Natl Acad Sci U S A 2011 May 31;108(22):9038-43 PMID: 21571638 PMCID: PMC3107315 SCOPUS ID: 2-s2.0-79959351596 05/17/2011 111 Citations

Telmisartan provides better renal protection than valsartan in a rat model of metabolic syndrome. (Khan AH, Imig JD) Am J Hypertens 2011 Jul;24(7):816-21 PMID: 21415842 PMCID: PMC3721747 SCOPUS ID: 2-s2.0-79959372114 03/19/2011 21 Citations

Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. (Sporková A, Kopkan L, Varcabová S, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Cervenka L) Am J Physiol Regul Integr Comp Physiol 2011 Jun;300(6):R1468-75 PMID: 21411763 PMCID: PMC3119161 SCOPUS ID: 2-s2.0-79958820824 03/18/2011 33 Citations

Cytochrome P450 eicosanoids and cerebral vascular function. (Imig JD, Simpkins AN, Renic M, Harder DR) Expert Rev Mol Med 2011 Mar 01;13:e7 PMID: 21356152 PMCID: PMC3613250 SCOPUS ID: 2-s2.0-79956129813 03/02/2011 56 Citations

Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. (Honetschlägerová Z, Husková Z, Vaňourková Z, Sporková A, Kramer HJ, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Červenka L, Kopkan L) J Physiol 2011 Jan 01;589(Pt 1):207-19 PMID: 21078594 PMCID: PMC3039270 SCOPUS ID: 2-s2.0-78650367090 11/17/2010 31 Citations

20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension. (Imig JD) Hypertension 2010 Nov;56(5):822-3 PMID: 20837886 PMCID: PMC2998348 SCOPUS ID: 2-s2.0-78149234273 09/15/2010 3 Citations

Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors. (Pavlov TS, Imig JD, Staruschenko A) PPAR Res 2010;2010:703735 PMID: 20613963 PMCID: PMC2896859 SCOPUS ID: 2-s2.0-77954592777 07/09/2010 12 Citations

Targeting epoxides for organ damage in hypertension. (Imig JD) J Cardiovasc Pharmacol 2010 Oct;56(4):329-35 PMID: 20531214 PMCID: PMC3071608 SCOPUS ID: 2-s2.0-77958468395 06/10/2010 46 Citations

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. (Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC) FASEB J 2010 Oct;24(10):3770-81 PMID: 20495177 PMCID: PMC2996903 SCOPUS ID: 2-s2.0-77957831701 05/25/2010 115 Citations

Epoxyeicosatrienoic acid analogs and vascular function. (Sudhahar V, Shaw S, Imig JD) Curr Med Chem 2010;17(12):1181-90 PMID: 20158473 PMCID: PMC2855336 SCOPUS ID: 2-s2.0-77950679870 02/18/2010 80 Citations

Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. (Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L) Clin Sci (Lond) 2010 Feb 23;118(10):617-32 PMID: 20050826 PMCID: PMC2854172 SCOPUS ID: 2-s2.0-77954063347 01/07/2010 39 Citations

Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions. (Imig JD, Elmarakby A, Nithipatikom K, Wei S, Capdevila JH, Tuniki VR, Sangras B, Anjaiah S, Manthati VL, Sudarshan Reddy D, Falck JR) Front Physiol 2010;1:157 PMID: 21423396 PMCID: PMC3059925 SCOPUS ID: 2-s2.0-84862963354 01/01/2010 43 Citations

Soluble epoxide hydrolase inhibition modulates vascular remodeling. (Simpkins AN, Rudic RD, Roy S, Tsai HJ, Hammock BD, Imig JD) Am J Physiol Heart Circ Physiol 2010 Mar;298(3):H795-806 PMID: 20035028 PMCID: PMC2838550 SCOPUS ID: 2-s2.0-77749279557 12/26/2009 36 Citations

The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension. (Imig JD, Carpenter MA, Shaw S) Pharmaceuticals (Basel) 2009 Dec 18;2(3):217-227 PMID: 27713235 PMCID: PMC3978544 SCOPUS ID: 2-s2.0-78751647808 12/18/2009 21 Citations

Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats. (Walkowska A, Skaroupková P, Husková Z, Vanourková Z, Chábová VC, Tesar V, Kramer HJ, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Cervenka L) J Hypertens 2010 Mar;28(3):582-93 PMID: 19940786 PMCID: PMC2855337 SCOPUS ID: 2-s2.0-77149129885 11/27/2009 21 Citations

Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension. (Knight SF, Yuan J, Roy S, Imig JD) Am J Physiol Renal Physiol 2010 Jan;298(1):F86-94 PMID: 19906952 PMCID: PMC3774183 SCOPUS ID: 2-s2.0-74049153900 11/13/2009 51 Citations

Adenosine2A receptors and epoxyeicosatrienoic acids: a recipe for salt and blood pressure regulation. (Imig JD) Hypertension 2009 Dec;54(6):1223-5 PMID: 19822801 PMCID: PMC2783356 SCOPUS ID: 2-s2.0-73349127839 10/14/2009 2 Citations

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. (Imig JD, Hammock BD) Nat Rev Drug Discov 2009 Oct;8(10):794-805 PMID: 19794443 PMCID: PMC3021468 SCOPUS ID: 2-s2.0-70349636047 10/02/2009 441 Citations

Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats. (Elmarakby AA, Imig JD) Clin Sci (Lond) 2010 Feb;118(4):291-301 PMID: 19728860 PMCID: PMC2842481 SCOPUS ID: 2-s2.0-70549099724 09/05/2009 65 Citations

Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice. (Quigley R, Chakravarty S, Zhao X, Imig JD, Capdevila JH) Nephron Physiol 2009;113(4):p23-8 PMID: 19713718 PMCID: PMC2790762 SCOPUS ID: 2-s2.0-69149108764 08/29/2009 21 Citations

Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. (Manhiani M, Quigley JE, Knight SF, Tasoobshirazi S, Moore T, Brands MW, Hammock BD, Imig JD) Am J Physiol Renal Physiol 2009 Sep;297(3):F740-8 PMID: 19553349 PMCID: PMC2739707 SCOPUS ID: 2-s2.0-69449093425 06/26/2009 110 Citations

Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. (Simpkins AN, Rudic RD, Schreihofer DA, Roy S, Manhiani M, Tsai HJ, Hammock BD, Imig JD) Am J Pathol 2009 Jun;174(6):2086-95 PMID: 19435785 PMCID: PMC2684174 SCOPUS ID: 2-s2.0-67049119782 05/14/2009 93 Citations

Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. (Sudhahar V et al.) Eur J Pharmacol 2009 Apr 1;607(1-3):143-150 PMID: 19374826 04/21/2009

Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries. (Sudhahar V, Shaw S, Imig JD) Eur J Pharmacol 2009 Apr 01;607(1-3):143-50 PMID: 19326479 PMCID: PMC2664517 SCOPUS ID: 2-s2.0-62149085894 03/28/2009 35 Citations

Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertension. (Quigley JE, Elmarakby AA, Knight SF, Manhiani MM, Stepp DW, Olearzcyk JJ, Imig JD) Clin Exp Pharmacol Physiol 2009 Jul;36(7):724-8 PMID: 19207724 PMCID: PMC2710419 SCOPUS ID: 2-s2.0-67650751654 02/12/2009 24 Citations

The Renal Microcirculation (Navar LG, Arendshorst WJ, Pallone TL, Inscho EW, Imig JD, Bell PD) Microcirculation 2008:550-683 SCOPUS ID: 2-s2.0-84882879271 12/01/2008 37 Citations

SPARC ameliorates ovarian cancer-associated inflammation. (Said NA, Elmarakby AA, Imig JD, Fulton DJ, Motamed K) Neoplasia 2008 Oct;10(10):1092-104 PMID: 18813349 PMCID: PMC2546586 SCOPUS ID: 2-s2.0-54249127338 09/25/2008 50 Citations

Increased blood pressure in mice lacking cytochrome P450 2J5. (Athirakul K, Bradbury JA, Graves JP, DeGraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Coffman TM, Zeldin DC) FASEB J 2008 Dec;22(12):4096-108 PMID: 18716027 PMCID: PMC2614614 SCOPUS ID: 2-s2.0-57349108805 08/22/2008 50 Citations

Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. (Chen JK, Chen J, Imig JD, Wei S, Hachey DL, Guthi JS, Falck JR, Capdevila JH, Harris RC) J Biol Chem 2008 Sep 05;283(36):24514-24 PMID: 18606824 PMCID: PMC2528993 SCOPUS ID: 2-s2.0-54049158142 07/09/2008 57 Citations

Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. (Olearczyk JJ, Quigley JE, Mitchell BC, Yamamoto T, Kim IH, Newman JW, Luria A, Hammock BD, Imig JD) Clin Sci (Lond) 2009 Jan;116(1):61-70 PMID: 18459944 PMCID: PMC2590620 SCOPUS ID: 2-s2.0-60549106716 05/08/2008 66 Citations

Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels. (Imig JD, Dimitropoulou C, Reddy DS, White RE, Falck JR) Microcirculation 2008 Feb;15(2):137-50 PMID: 18260004 PMCID: PMC2654618 SCOPUS ID: 2-s2.0-38949115541 02/09/2008 55 Citations

Eicosanoids and renal damage in cardiometabolic syndrome. (Imig JD) Expert Opin Drug Metab Toxicol 2008 Feb;4(2):165-74 PMID: 18248310 PMCID: PMC3348552 SCOPUS ID: 2-s2.0-39749161642 02/06/2008 47 Citations

Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet. (Knight SF, Quigley JE, Yuan J, Roy SS, Elmarakby A, Imig JD) Hypertension 2008 Feb;51(2):352-9 PMID: 18158349 PMCID: PMC2491336 SCOPUS ID: 2-s2.0-38549099062 12/26/2007 94 Citations

TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. (Elmarakby AA, Quigley JE, Imig JD, Pollock JS, Pollock DM) Am J Physiol Regul Integr Comp Physiol 2008 Jan;294(1):R76-83 PMID: 17989143 PMCID: PMC2820582 SCOPUS ID: 2-s2.0-38148999322 11/09/2007 105 Citations

Normalization of the ovarian cancer microenvironment by SPARC. (Said N, Socha MJ, Olearczyk JJ, Elmarakby AA, Imig JD, Motamed K) Mol Cancer Res 2007 Oct;5(10):1015-30 PMID: 17951402 SCOPUS ID: 2-s2.0-35948982192 10/24/2007 71 Citations

Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension. (Elmarakby AA, Quigley JE, Olearczyk JJ, Sridhar A, Cook AK, Inscho EW, Pollock DM, Imig JD) Hypertension 2007 Dec;50(6):1069-76 PMID: 17938380 PMCID: PMC2491337 SCOPUS ID: 2-s2.0-36448998082 10/17/2007 55 Citations

The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats. (Certíková Chábová V, Kramer HJ, Vanecková I, Thumová M, Skaroupková P, Tesar V, Falck JR, Imig JD, Cervenka L) Kidney Blood Press Res 2007;30(5):335-46 PMID: 17785988 SCOPUS ID: 2-s2.0-34748856828 09/06/2007 11 Citations

Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. (Socha MJ, Manhiani M, Said N, Imig JD, Motamed K) Am J Pathol 2007 Oct;171(4):1104-12 PMID: 17717147 PMCID: PMC1988862 SCOPUS ID: 2-s2.0-35348852466 08/25/2007 52 Citations

Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. (Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD) J Clin Invest 2007 Sep;117(9):2496-505 PMID: 17710229 PMCID: PMC1940235 SCOPUS ID: 2-s2.0-34848921161 08/22/2007 81 Citations

Obesity, insulin resistance, and renal function. (Knight SF, Imig JD) Microcirculation 2007 Jun-Jul;14(4-5):349-62 PMID: 17613807 SCOPUS ID: 2-s2.0-34447325896 07/07/2007 64 Citations

Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats. (Chábová VC, Kramer HJ, Vanecková I, Vernerová Z, Eis V, Tesar V, Skaroupková P, Thumová M, Schejbalová S, Husková Z, Vanourková Z, Kolský A, Imig JD, Cervenka L) Vascul Pharmacol 2007 Aug-Sep;47(2-3):145-59 PMID: 17604232 SCOPUS ID: 2-s2.0-34547100988 07/03/2007 34 Citations

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. (Capdevila JH, Falck JR, Imig JD) Kidney Int 2007 Sep;72(6):683-9 PMID: 17597703 SCOPUS ID: 2-s2.0-34548480936 06/29/2007 91 Citations

IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension. (Manhiani MM, Quigley JE, Socha MJ, Motamed K, Imig JD) Kidney Blood Press Res 2007;30(4):195-202 PMID: 17575466 SCOPUS ID: 2-s2.0-34447549006 06/19/2007 14 Citations

Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive rats. (Kang KT, Sullivan JC, Sasser JM, Imig JD, Pollock JS) Hypertension 2007 Apr;49(4):893-901 PMID: 17309950 SCOPUS ID: 2-s2.0-34047218002 02/21/2007 38 Citations

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation. (Dimitropoulou C, West L, Field MB, White RE, Reddy LM, Falck JR, Imig JD) Prostaglandins Other Lipid Mediat 2007 Feb;83(1-2):50-61 PMID: 17259072 SCOPUS ID: 2-s2.0-33846414370 01/30/2007 42 Citations

Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension. (Elmarakby AA, Williams JM, Imig JD, Pollock JS, Pollock DM) Vascul Pharmacol 2007 Feb;46(2):144-51 PMID: 17112788 PMCID: PMC2746434 SCOPUS ID: 2-s2.0-33845561904 11/23/2006 13 Citations

Renal dysfunction in hypertension and obesity (Elmarakby AA, Pollock DM, Imig JD) Comprehensive Medicinal Chemistry II November 2006;6:575-595 SCOPUS ID: 2-s2.0-84906448953 11/01/2006 5 Citations

Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors. (Imig JD) Cardiovasc Drug Rev 2006;24(2):169-88 PMID: 16961727 SCOPUS ID: 2-s2.0-34247867952 09/12/2006 74 Citations

Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. (Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD) J Pharmacol Exp Ther 2006 Sep;318(3):1307-14 PMID: 16772540 SCOPUS ID: 2-s2.0-33747611948 06/15/2006 39 Citations

Eicosanoids and renal vascular function in diseases. (Imig JD) Clin Sci (Lond) 2006 Jul;111(1):21-34 PMID: 16764555 SCOPUS ID: 2-s2.0-33745797993 06/13/2006 76 Citations

Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE. (Joly E, Seqqat R, Flamion B, Caron N, Michel A, Imig JD, Kramp R) Am J Physiol Regul Integr Comp Physiol 2006 Oct;291(4):R977-86 PMID: 16675634 SCOPUS ID: 2-s2.0-33749346983 05/06/2006 27 Citations

Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats. (Jin L, Ying Z, Hilgers RH, Yin J, Zhao X, Imig JD, Webb RC) J Pharmacol Exp Ther 2006 Jul;318(1):288-95 PMID: 16569756 SCOPUS ID: 2-s2.0-33745285003 03/30/2006 80 Citations

PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats. (Zhao X, Quigley JE, Yuan J, Wang MH, Zhou Y, Imig JD) Am J Physiol Heart Circ Physiol 2006 Jun;290(6):H2187-95 PMID: 16501022 SCOPUS ID: 2-s2.0-33744940507 02/28/2006 49 Citations

Eicosanoid inhibitors as therapeutic targets for metabolic syndrome related kidney disease (Imig JD, Zhao X) Current Enzyme Inhibition February 2006;2(1):73-77 SCOPUS ID: 2-s2.0-33746131244 02/01/2006

Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. (Elmarakby AA, Quigley JE, Pollock DM, Imig JD) Hypertension 2006 Mar;47(3):557-62 PMID: 16415373 SCOPUS ID: 2-s2.0-33644989494 01/18/2006 95 Citations

Cytochrome P450 epoxygenases provide a novel mechanism for penile erection. (Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC) FASEB J 2006 Mar;20(3):539-41 PMID: 16415108 SCOPUS ID: 2-s2.0-33645817293 01/18/2006 18 Citations

An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. (Dorrance AM, Rupp N, Pollock DM, Newman JW, Hammock BD, Imig JD) J Cardiovasc Pharmacol 2005 Dec;46(6):842-8 PMID: 16306811 PMCID: PMC1444897 SCOPUS ID: 2-s2.0-33644697099 11/25/2005 104 Citations

Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. (Lee DL, Sturgis LC, Labazi H, Osborne JB Jr, Fleming C, Pollock JS, Manhiani M, Imig JD, Brands MW) Am J Physiol Heart Circ Physiol 2006 Mar;290(3):H935-40 PMID: 16284237 SCOPUS ID: 2-s2.0-33645744262 11/15/2005 183 Citations

Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes. (Portik-Dobos V, Harris AK, Song W, Hutchinson J, Johnson MH, Imig JD, Pollock DM, Ergul A) Am J Physiol Regul Integr Comp Physiol 2006 Feb;290(2):R435-41 PMID: 16239374 SCOPUS ID: 2-s2.0-33644871367 10/22/2005 29 Citations

ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin. (Inscho EW, Imig JD, Cook AK, Pollock DM) Br J Pharmacol 2005 Dec;146(7):1019-26 PMID: 16231007 PMCID: PMC1751231 SCOPUS ID: 2-s2.0-28444465856 10/19/2005 71 Citations

An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. (Imig JD, Zhao X, Zaharis CZ, Olearczyk JJ, Pollock DM, Newman JW, Kim IH, Watanabe T, Hammock BD) Hypertension 2005 Oct;46(4):975-81 PMID: 16157792 PMCID: PMC1444888 SCOPUS ID: 2-s2.0-33644654633 09/15/2005 205 Citations

Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension. (Zhao X, Cook AK, Field M, Edwards B, Zhang S, Zhang Z, Pollock JS, Imig JD, Inscho EW) Hypertension 2005 Sep;46(3):562-8 PMID: 16116048 SCOPUS ID: 2-s2.0-25444437790 08/24/2005 37 Citations

Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases. (Imig JD) Am J Physiol Renal Physiol 2005 Sep;289(3):F496-503 PMID: 16093425 SCOPUS ID: 2-s2.0-23944460748 08/12/2005 186 Citations

Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. (Williams JM, Zhao X, Wang MH, Imig JD, Pollock DM) Hypertension 2005 Aug;46(2):366-71 PMID: 15967866 SCOPUS ID: 2-s2.0-23244463712 06/22/2005 34 Citations

Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells. (Fuller AJ, Hauschild BC, Gonzalez-Villalobos R, Awayda MS, Imig JD, Inscho EW, Navar LG) Am J Physiol Renal Physiol 2005 Oct;289(4):F760-7 PMID: 15942047 PMCID: PMC1314975 SCOPUS ID: 2-s2.0-24944582897 06/09/2005 22 Citations

CYP450, COX-2 and Obesity Related Renal Damage. (Imig JD, Zhao X, Dey A, Shaw M) Toxicol Mech Methods 2005;15(2):125-36 PMID: 20021073 SCOPUS ID: 2-s2.0-18344389738 01/01/2005 8 Citations

L-type calcium channels in the renal microcirculatory response to endothelin. (Pollock DM, Jenkins JM, Cook AK, Imig JD, Inscho EW) Am J Physiol Renal Physiol 2005 Apr;288(4):F771-7 PMID: 15547114 SCOPUS ID: 2-s2.0-15044341328 11/18/2004 23 Citations

Erratum: 20-HETE or EETs: Which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis? (American Journal of Physiology - Regulatory Integrative and Comparative Physiology (July 2004) 56 (R3-R5)) (Imig JD) American Journal of Physiology - Regulatory Integrative and Comparative Physiology October 2004;287(4 56-4) SCOPUS ID: 2-s2.0-19444384724 10/01/2004

Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats. (Zhao X, Dey A, Romanko OP, Stepp DW, Wang MH, Zhou Y, Jin L, Pollock JS, Webb RC, Imig JD) Am J Physiol Regul Integr Comp Physiol 2005 Jan;288(1):R188-96 PMID: 15345471 SCOPUS ID: 2-s2.0-19944424115 09/04/2004 70 Citations

Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. (Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD) Obes Res 2004 Aug;12(8):1278-89 PMID: 15340111 SCOPUS ID: 2-s2.0-6344282521 09/02/2004 48 Citations

P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid. (Zhao X, Falck JR, Gopal VR, Inscho EW, Imig JD) J Pharmacol Exp Ther 2004 Dec;311(3):1211-7 PMID: 15316085 SCOPUS ID: 2-s2.0-10044255250 08/19/2004 24 Citations

Rofecoxib decreases renal injury in obese Zucker rats. (Dey A, Maric C, Kaesemeyer WH, Zaharis CZ, Stewart J, Pollock JS, Imig JD) Clin Sci (Lond) 2004 Dec;107(6):561-70 PMID: 15307815 SCOPUS ID: 2-s2.0-10344226649 08/17/2004 38 Citations

Renal autoregulation in P2X1 knockout mice. (Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ) Acta Physiol Scand 2004 Aug;181(4):445-53 PMID: 15283757 SCOPUS ID: 2-s2.0-4043150035 07/31/2004 55 Citations

20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis? (Imig JD) Am J Physiol Regul Integr Comp Physiol 2004 Jul;287(1):R3-5 PMID: 15191921 SCOPUS ID: 2-s2.0-3042826878 06/12/2004 15 Citations

Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats. (Sullivan JC, Loomis ED, Collins M, Imig JD, Inscho EW, Pollock JS) J Appl Physiol (1985) 2004 Oct;97(4):1268-74 PMID: 15169747 SCOPUS ID: 2-s2.0-4644220739 06/01/2004 23 Citations

Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation. (Inscho EW, Cook AK, Murzynowski JB, Imig JD) J Hypertens 2004 Apr;22(4):811-8 PMID: 15126924 SCOPUS ID: 2-s2.0-2142771178 05/06/2004 29 Citations

Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. (Zhao X, Yamamoto T, Newman JW, Kim IH, Watanabe T, Hammock BD, Stewart J, Pollock JS, Pollock DM, Imig JD) J Am Soc Nephrol 2004 May;15(5):1244-53 PMID: 15100364 SCOPUS ID: 2-s2.0-11144356945 04/22/2004 197 Citations

ACE Inhibition and Bradykinin-Mediated Renal Vascular Responses: EDHF Involvement. (Imig JD) Hypertension 2004 Mar;43(3):533-5 PMID: 14757781 SCOPUS ID: 2-s2.0-1442313018 02/06/2004 37 Citations

Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. (Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ) J Clin Invest 2003 Dec;112(12):1895-905 PMID: 14679185 PMCID: PMC296993 SCOPUS ID: 2-s2.0-0346690401 12/18/2003 142 Citations

The Bradykinin B2 receptor is required for full expression of renal COX-2 and renin. (Imig JD, Zhao X, Orengo SR, Dipp S, El-Dahr SS) Peptides 2003 Aug;24(8):1141-7 PMID: 14612184 SCOPUS ID: 2-s2.0-0242551429 11/13/2003 17 Citations

12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels. (Yiu SS, Zhao X, Inscho EW, Imig JD) J Lipid Res 2003 Dec;44(12):2391-9 PMID: 12951362 SCOPUS ID: 2-s2.0-0347093588 09/03/2003 38 Citations

Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension. (Wang MH, Smith A, Zhou Y, Chang HH, Lin S, Zhao X, Imig JD, Dorrance AM) Hypertension 2003 Oct;42(4):594-9 PMID: 12939236 SCOPUS ID: 2-s2.0-0141997230 08/27/2003 70 Citations

Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenases. (Zhao X, Pollock DM, Zeldin DC, Imig JD) Hypertension 2003 Oct;42(4):775-80 PMID: 12900436 SCOPUS ID: 2-s2.0-0141997292 08/06/2003 33 Citations

Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension. (Zhao X, Pollock DM, Inscho EW, Zeldin DC, Imig JD) Hypertension 2003 Mar;41(3 Pt 2):709-14 PMID: 12623984 SCOPUS ID: 2-s2.0-0037338752 03/08/2003 90 Citations

Kidney CYP450 enzymes: biological actions beyond drug metabolism. (Zhao X, Imig JD) Curr Drug Metab 2003 Feb;4(1):73-84 PMID: 12570747 SCOPUS ID: 2-s2.0-0037302804 02/07/2003 79 Citations

Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in mice. (Imig JD, Breyer MD, Breyer RM) Am J Physiol Renal Physiol 2002 Sep;283(3):F415-22 PMID: 12167591 SCOPUS ID: 2-s2.0-0036721068 08/09/2002 41 Citations

Adaptations of the renal microcirculation to hypertension. (Imig JD, Inscho EW) Microcirculation 2002;9(4):315-28 PMID: 12152107 SCOPUS ID: 2-s2.0-0038342262 08/02/2002 25 Citations

Renal AT1 receptor protein expression during the early stage of diabetes mellitus. (Harrison-Bernard LM, Imig JD, Carmines PK) Int J Exp Diabetes Res 2002 Apr-Jun;3(2):97-108 PMID: 11991202 PMCID: PMC2478573 SCOPUS ID: 2-s2.0-0036012687 05/07/2002 36 Citations

Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. (Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD) Hypertension 2002 Feb;39(2 Pt 2):690-4 PMID: 11882632 SCOPUS ID: 2-s2.0-0036179501 03/08/2002 332 Citations

Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. (Zhuo JL, Imig JD, Hammond TG, Orengo S, Benes E, Navar LG) Hypertension 2002 Jan;39(1):116-21 PMID: 11799089 SCOPUS ID: 2-s2.0-0036150723 01/19/2002 126 Citations

The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. (Zhao X, Inscho EW, Bondlela M, Falck JR, Imig JD) Am J Physiol Heart Circ Physiol 2001 Nov;281(5):H2089-96 PMID: 11668070 SCOPUS ID: 2-s2.0-0035203299 10/23/2001 40 Citations

Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium release. (Imig JD, Cook AK, Inscho EW) Gen Pharmacol 2000 Jun;34(6):409-15 PMID: 11483290 SCOPUS ID: 2-s2.0-0034434598 08/03/2001 16 Citations

Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin. (Imig JD, Falck JR, Wei S, Capdevila JH) J Vasc Res 2001 May-Jun;38(3):247-55 PMID: 11399897 SCOPUS ID: 2-s2.0-0034961040 06/16/2001 102 Citations

Unraveling the Mystery of Goldblatt Hypertension. (Navar LG, Zou L, Von Thun A, Tarng Wang C, Imig JD, Mitchell KD) News Physiol Sci 1998 Aug;13:170-176 PMID: 11390784 SCOPUS ID: 2-s2.0-22044435274 06/08/2001 112 Citations

Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. (Imig JD, Zhao X, Falck JR, Wei S, Capdevila JH) J Hypertens 2001 May;19(5):983-92 PMID: 11393683 SCOPUS ID: 2-s2.0-0035024260 06/08/2001 55 Citations

Calcium signaling pathways utilized by P2X receptors in freshly isolated preglomerular MVSMC. (White SM, Imig JD, Kim TT, Hauschild BC, Inscho EW) Am J Physiol Renal Physiol 2001 Jun;280(6):F1054-61 PMID: 11352845 SCOPUS ID: 2-s2.0-0034979794 05/16/2001 41 Citations

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. (Holla VR, Adas F, Imig JD, Zhao X, Price E Jr, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH) Proc Natl Acad Sci U S A 2001 Apr 24;98(9):5211-6 PMID: 11320253 PMCID: PMC33189 SCOPUS ID: 2-s2.0-0035942194 04/26/2001 208 Citations

Epoxygenase metabolites. Epithelial and vascular actions. (Imig JD) Mol Biotechnol 2000 Nov;16(3):233-51 PMID: 11252808 SCOPUS ID: 2-s2.0-0034467906 03/17/2001 36 Citations

Measurement of Renal Tubular Angiotensin II. (Imig JD, Gabriel Navar L) Methods Mol Med 2001;51:427-34 PMID: 21331734 01/01/2001

Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat. (Zimpelmann J, Kumar D, Levine DZ, Wehbi G, Imig JD, Navar LG, Burns KD) Kidney Int 2000 Dec;58(6):2320-30 PMID: 11115066 SCOPUS ID: 2-s2.0-0033672308 12/15/2000 115 Citations

Eicosanoid regulation of the renal vasculature. (Imig JD) Am J Physiol Renal Physiol 2000 Dec;279(6):F965-81 PMID: 11097615 SCOPUS ID: 2-s2.0-0034534288 11/30/2000 176 Citations

Afferent arteriolar reactivity to angiotensin II is enhanced during the early phase of angiotensin II hypertension. (Imig JD) Am J Hypertens 2000 Jul;13(7):810-8 PMID: 10933574 SCOPUS ID: 2-s2.0-0033861785 08/10/2000 41 Citations

Renal responses to AT1 receptor blockade. (Navar LG, Harrison-Bernard LM, Imig JD, Cervenka L, Mitchell KD) Am J Hypertens 2000 Jan;13(1 Pt 2):45S-54S PMID: 10678288 SCOPUS ID: 2-s2.0-0033630217 03/11/2000 47 Citations

Nitric oxide-angiotensin II interactions in angiotensin II-dependent hypertension. (Navar LG, Ichihara A, Chin SY, Imig JD) Acta Physiol Scand 2000 Jan;168(1):139-47 PMID: 10691792 SCOPUS ID: 2-s2.0-0034105586 02/26/2000 58 Citations

Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses. (Imig JD, Pham BT, LeBlanc EA, Reddy KM, Falck JR, Inscho EW) Hypertension 2000 Jan;35(1 Pt 2):307-12 PMID: 10642316 SCOPUS ID: 2-s2.0-0343820031 01/21/2000 79 Citations

Endothelin-mediated calcium signaling in preglomerular smooth muscle cells. (Schroeder AC, Imig JD, LeBlanc EA, Pham BT, Pollock DM, Inscho EW) Hypertension 2000 Jan;35(1 Pt 2):280-6 PMID: 10642311 SCOPUS ID: 2-s2.0-0033966507 01/21/2000 34 Citations

Nonendothelial paracrine regulation of the renal microcirculation (Inscho EW, Imig JD, Navar LG) Advances in Organ Biology 2000;9:219-233 SCOPUS ID: 2-s2.0-35448985388 01/01/2000

Cyclooxygenase-2 modulates afferent arteriolar responses to increases in pressure. (Ichihara A, Imig JD, Navar LG) Hypertension 1999 Oct;34(4 Pt 2):843-7 PMID: 10523371 SCOPUS ID: 2-s2.0-0032711842 10/16/1999 50 Citations

Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. (Imig JD, Falck JR, Inscho EW) Br J Pharmacol 1999 Jul;127(6):1399-405 PMID: 10455289 PMCID: PMC1760652 SCOPUS ID: 2-s2.0-0032784521 08/24/1999 79 Citations

Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice. (Cervenka L, Harrison-Bernard LM, Dipp S, Primrose G, Imig JD, El-Dahr SS) Hypertension 1999 Aug;34(2):176-80 PMID: 10454437 SCOPUS ID: 2-s2.0-0032819548 08/24/1999 61 Citations

Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors. (Imig JD, Navar GL, Zou LX, O'Reilly KC, Allen PL, Kaysen JH, Hammond TG, Navar LG) Am J Physiol 1999 08;277(2):F303-11 PMID: 10444586 SCOPUS ID: 2-s2.0-0032829061 08/13/1999 76 Citations

Epoxyeicosatrienoic acids. Biosynthesis, regulation, and actions. (Imig JD) Methods Mol Biol 1999;120:173-92 PMID: 10343317 SCOPUS ID: 2-s2.0-0032611973 05/27/1999 11 Citations

Intrarenal angiotensin II generation and renal effects of AT1 receptor blockade. (Navar LG, Harrison-Bernard LM, Imig JD, Wang CT, Cervenka L, Mitchell KD) J Am Soc Nephrol 1999 Apr;10 Suppl 12:S266-72 PMID: 10201881 SCOPUS ID: 2-s2.0-0032943964 04/14/1999 92 Citations

ATP-mediated Ca2+ signaling in preglomerular smooth muscle cells. (Inscho EW, Schroeder AC, Deichmann PC, Imig JD) Am J Physiol 1999 03;276(3):F450-6 PMID: 10070169 SCOPUS ID: 2-s2.0-0032898639 03/10/1999 24 Citations

Neuronal nitric oxide synthase-dependent afferent arteriolar function in angiotensin II-induced hypertension. (Ichihara A, Imig JD, Navar LG) Hypertension 1999 Jan;33(1 Pt 2):462-6 PMID: 9931148 SCOPUS ID: 2-s2.0-0032946116 02/04/1999 20 Citations

Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A. (Imig JD, Inscho EW, Deichmann PC, Reddy KM, Falck JR) Hypertension 1999 Jan;33(1 Pt 2):408-13 PMID: 9931138 SCOPUS ID: 2-s2.0-0032942665 02/04/1999 88 Citations

Purinoceptor-mediated calcium signaling in preglomerular smooth muscle cells. (Inscho EW, LeBlanc EA, Pham BT, White SM, Imig JD) Hypertension 1999 Jan;33(1 Pt 2):195-200 PMID: 9931104 SCOPUS ID: 2-s2.0-0032898185 02/04/1999 42 Citations

Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats. (Inscho EW, Imig JD, Deichmann PC, Cook AK) J Am Soc Nephrol 1999 Jan;10 Suppl 11:S178-83 PMID: 9892160 SCOPUS ID: 2-s2.0-0032945482 01/19/1999 49 Citations

Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS. (Ichihara A, Imig JD, Inscho EW, Navar LG) Am J Physiol 1998 10;275(4):F605-12 PMID: 9755132 SCOPUS ID: 2-s2.0-0031755248 10/01/1998 86 Citations

Heterogeneous activation mechanisms in the renal microvasculature. (Navar LG, Inscho EW, Imig JD, Mitchell KD) Kidney Int Suppl 1998 Sep;67:S17-21 PMID: 9736247 SCOPUS ID: 2-s2.0-0032160469 09/15/1998 26 Citations

Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. (Zou LX, Imig JD, Hymel A, Navar LG) Am J Hypertens 1998 May;11(5):570-8 PMID: 9633793 SCOPUS ID: 2-s2.0-0031839482 06/20/1998 83 Citations

Interactive nitric oxide-angiotensin II influences on renal microcirculation in angiotensin II-induced hypertension. (Ichihara A, Imig JD, Inscho EW, Navar LG) Hypertension 1998 Jun;31(6):1255-60 PMID: 9622138 SCOPUS ID: 2-s2.0-0031840663 06/11/1998 38 Citations

Neuronal nitric oxide synthase modulates rat renal microvascular function. (Ichihara A, Inscho EW, Imig JD, Navar LG) Am J Physiol 1998 03;274(3):F516-24 PMID: 9530268 SCOPUS ID: 2-s2.0-0031945589 04/08/1998 118 Citations

Perfusion pressure dependent augmentation of afferent arteriolar vasoconstriction to increased distal nephron volume delivery (Ichihara A, Inscho EW, Imig JD, Navar LG) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-33749352337 03/20/1998

Calcium mobilization contributes to pressure-mediated afferent arteriolar vasoconstriction. (Inscho EW, Cook AK, Mui V, Imig JD) Hypertension 1998 Jan;31(1 Pt 2):421-8 PMID: 9453339 SCOPUS ID: 2-s2.0-0031612047 02/07/1998 39 Citations

Unraveling the mystery of goldblatt hypertension (Navar LG, Zou L, Von Thun A, Wang CT, Imig JD, Mitchell KD) News in Physiological Sciences August 1998;13(4):170-176 SCOPUS ID: 2-s2.0-22044435274 01/01/1998 112 Citations

ATP increases cytosolic CA²⁺ concentration in renal microvascular smooth muscle cells (MVSMC) through a thapsigargin-insensitive pathway (Inscho EW, Deichmann PC, Imig JD) FASEB Journal 1997;11(3) SCOPUS ID: 2-s2.0-33750228632 12/01/1997

Neuronal nitric oxide synthase (nNOS) enhances efferent but not afferent arteriolar reactivity to angiotensin II (ANGII) (Ichihara A, Inscho EW, Imig JD, Navar LG) FASEB Journal 1997;11(3) SCOPUS ID: 2-s2.0-33750139975 12/01/1997

Intrarenal production of angiotensin II. (Navar LG, Imig JD, Zou L, Wang CT) Semin Nephrol 1997 Sep;17(5):412-22 PMID: 9316209 SCOPUS ID: 2-s2.0-0030885195 10/08/1997 174 Citations

Afferent arteriolar responses to ANG II involve activation of PLA2 and modulation by lipoxygenase and P-450 pathways. (Imig JD, Deichmann PC) Am J Physiol 1997 Aug;273(2 Pt 2):F274-82 PMID: 9277588 SCOPUS ID: 2-s2.0-0030865284 08/01/1997 64 Citations

Agonist-induced calcium regulation in freshly isolated renal microvascular smooth muscle cells. (Inscho EW, Mason MJ, Schroeder AC, Deichmann PC, Stiegler KD, Imig JD) J Am Soc Nephrol 1997 Apr;8(4):569-79 PMID: 10495786 SCOPUS ID: 2-s2.0-0030660278 04/01/1997 36 Citations

Effects of phospholipase A2, 12-lipoxygenase, and cyclooxygenase inhibitors in the feline pulmonary bed. (Kaye AD, Nossaman BD, Smith DE, Ibrahim IN, Imig JD, Kadowitz PJ) Am J Physiol 1997 Apr;272(4 Pt 1):L573-9 PMID: 9142927 SCOPUS ID: 2-s2.0-0031115093 04/01/1997 9 Citations

Role of renal nerves in afferent arteriolar reactivity in angiotensin-induced hypertension. (Ichihara A, Inscho EW, Imig JD, Michel RE, Navar LG) Hypertension 1997 Jan;29(1 Pt 2):442-9 PMID: 9039140 SCOPUS ID: 2-s2.0-0031028510 01/01/1997 49 Citations

Afferent and efferent arteriolar vasoconstriction to angiotensin II and norepinephrine involves release of Ca2+ from intracellular stores. (Inscho EW, Imig JD, Cook AK) Hypertension 1997 Jan;29(1 Pt 2):222-7 PMID: 9039106 SCOPUS ID: 2-s2.0-0031019696 01/01/1997 61 Citations

Enhanced renal microvascular tone in angiotensin ii-induced hypertension (Imig JD, Deichmann PC, Navar LG) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33749163347 12/01/1996

Renal uptake of circulating angiotensin II iang II in VAL5-ang II infused rats is mediated by at, receptor (Zou LX, Imig JD, Hvmel A, Navar LG) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-10144230334 12/01/1996 1 Citation

Actions of epoxygenase metabolites on the preglomerular vasculature. (Imig JD, Navar LG, Roman RJ, Reddy KK, Falck JR) J Am Soc Nephrol 1996 Nov;7(11):2364-70 PMID: 8959626 SCOPUS ID: 2-s2.0-0030358016 11/01/1996 177 Citations

Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. (Zou LX, Imig JD, von Thun AM, Hymel A, Ono H, Navar LG) Hypertension 1996 Oct;28(4):669-77 PMID: 8843896 SCOPUS ID: 2-s2.0-0029797409 10/01/1996 175 Citations

Identification of a putative microvascular oxygen sensor. (Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, Roman RJ) Circ Res 1996 Jul;79(1):54-61 PMID: 8925569 SCOPUS ID: 2-s2.0-0029947046 07/01/1996 163 Citations

Afferent arteriolar response to arachidonic acid: involvement of metabolic pathways. (Imig JD, Navar LG) Am J Physiol 1996 Jul;271(1 Pt 2):F87-93 PMID: 8760247 SCOPUS ID: 2-s2.0-0029781611 07/01/1996 16 Citations

Paracrine regulation of the renal microcirculation. (Navar LG, Inscho EW, Majid SA, Imig JD, Harrison-Bernard LM, Mitchell KD) Physiol Rev 1996 Apr;76(2):425-536 PMID: 8618962 SCOPUS ID: 2-s2.0-0029995999 04/01/1996 644 Citations

Renal accumulation of circulating angiotensin II in angiotensin II-infused rats. (Zou LX, Hymel A, Imig JD, Navar LG) Hypertension 1996 Mar;27(3 Pt 2):658-62 PMID: 8613220 SCOPUS ID: 2-s2.0-0029926379 03/01/1996 91 Citations

Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. (Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):R217-27 PMID: 8769805 SCOPUS ID: 2-s2.0-0030028233 01/01/1996 255 Citations

Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. (Zou AP, Imig JD, Ortiz de Montellano PR, Sui Z, Falck JR, Roman RJ) Am J Physiol 1994 Jun;266(6 Pt 2):F934-41 PMID: 8023972 SCOPUS ID: 2-s2.0-0028284028 06/01/1994 133 Citations

Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. (Imig JD, Zou AP, Ortiz de Montellano PR, Sui Z, Roman RJ) Am J Physiol 1994 May;266(5 Pt 2):H1879-85 PMID: 8203587 SCOPUS ID: 2-s2.0-0028335404 05/01/1994 84 Citations

Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. (Zou AP, Imig JD, Kaldunski M, Ortiz de Montellano PR, Sui Z, Roman RJ) Am J Physiol 1994 Feb;266(2 Pt 2):F275-82 PMID: 8141328 SCOPUS ID: 2-s2.0-0028296987 02/01/1994 182 Citations

Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. (Imig JD, Falck JR, Gebremedhin D, Harder DR, Roman RJ) Hypertension 1993 Sep;22(3):357-64 PMID: 8349328 SCOPUS ID: 2-s2.0-0027301319 09/01/1993 107 Citations

Chloride alters renal blood flow autoregulation in deoxycorticosterone-treated rats. (Imig JD, Passmore JC, Anderson GL, Jimenez AE) J Lab Clin Med 1993 Apr;121(4):608-13 PMID: 8454943 SCOPUS ID: 2-s2.0-0027481297 04/01/1993 21 Citations

Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. (Gebremedhin D, Ma YH, Imig JD, Harder DR, Roman RJ) J Vasc Res 1993 Jan-Feb;30(1):53-60 PMID: 8435472 SCOPUS ID: 2-s2.0-0027471234 01/01/1993 53 Citations

Modulation of vascular tone in renal microcirculation by erythrocytes: role of EDRF. (Imig JD, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1993 Jan;264(1 Pt 2):H190-5 PMID: 8430846 SCOPUS ID: 2-s2.0-0027404794 01/01/1993 35 Citations

Nitric oxide modulates vascular tone in preglomerular arterioles. (Imig JD, Roman RJ) Hypertension 1992 Jun;19(6 Pt 2):770-4 PMID: 1592479 SCOPUS ID: 2-s2.0-0026503458 06/01/1992 86 Citations

Small artery resistance increases during the development of renal hypertension. (Imig JD, Anderson GL) Hypertension 1991 Mar;17(3):317-22 PMID: 1999362 SCOPUS ID: 2-s2.0-0025966845 03/01/1991 13 Citations

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John D. Imig PhD

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Publications (249)