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Medical College of Wisconsin

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John W. Lough PhD, MS

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Cell Biology Neurobiology and Anatomy

Member of the Cardiovascular Research Center

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Publications (98)

Mitigation of Injury from Myocardial Infarction by Pentamidine, an Inhibitor of the Acetyltransferase Tip60. (Wang X, Harty KR, Wan TC, Qu Z, Smith BC, Lough JW, Auchampach JA) Cardiovasc Drugs Ther 2026 Feb;40(1):141-154 PMID: 40202550 PMCID: PMC12641756 SCOPUS ID: 2-s2.0-105002184326 04/09/2025 2 Citations

Histone H2A.Z Deacetylation and Dedifferentiation in Infarcted/Tip60-depleted Cardiomyocytes. (Wang X, Kulik K, Wan TC, Lough JW, Auchampach JA) bioRxiv 2025 Jan 16 PMID: 38260622 PMCID: PMC10802610 01/23/2024

Altered contractility, Ca²⁺ transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein's anomaly with left ventricular noncompaction. (Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm K, Afzal MZ, Strande J, Frommelt MA, Lough JW, Fitts RH, Mitchell ME, Tomita-Mitchell A) Am J Physiol Heart Circ Physiol 2023 Jul 01;325(1):H149-H162 PMID: 37204873 PMCID: PMC10312315 SCOPUS ID: 2-s2.0-85164047409 05/19/2023 3 Citations

Collagen-Specific HSP47⁺ Myofibroblasts and CD163⁺ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. (Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ) J Am Heart Assoc 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023 9 Citations

Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury. (Wang X, Wan TC, Kulik KR, Lauth A, Smith BC, Lough JW, Auchampach JA) Dis Model Mech 2023 May 01;16(5) PMID: 36341679 PMCID: PMC9672930 SCOPUS ID: 2-s2.0-85141362492 11/08/2022 13 Citations

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases. (Anfinson M, Fitts RH, Lough JW, James JM, Simpson PM, Handler SS, Mitchell ME, Tomita-Mitchell A) J Cardiovasc Dev Dis 2022 May 03;9(5) PMID: 35621855 PMCID: PMC9147009 SCOPUS ID: 2-s2.0-85130146333 05/28/2022 29 Citations

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases (Anfinson M, Fitts RH, Lough JW, James JM, Simpson PM, Handler SS, Mitchell ME, Tomita-Mitchell A) Journal of Cardiovascular Development and Disease May 2022;9(5) SCOPUS ID: 2-s2.0-85130146333 05/01/2022 30 Citations

A Systematic Review of Ebstein's Anomaly with Left Ventricular Noncompaction. (Thareja SK, Frommelt MA, Lincoln J, Lough JW, Mitchell ME, Tomita-Mitchell A) J Cardiovasc Dev Dis 2022 Apr 13;9(4) PMID: 35448091 PMCID: PMC9031964 SCOPUS ID: 2-s2.0-85129039352 04/22/2022 12 Citations

Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration. (Auchampach J, Han L, Huang GN, Kühn B, Lough JW, O'Meara CC, Payumo AY, Rosenthal NA, Sucov HM, Yutzey KE, Patterson M) Am J Physiol Heart Circ Physiol 2022 Apr 01;322(4):H579-H596 PMID: 35179974 PMCID: PMC8934681 SCOPUS ID: 2-s2.0-85127729067 02/19/2022 37 Citations

Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction. (Wang X, Wan TC, Lauth A, Purdy AL, Kulik KR, Patterson M, Lough JW, Auchampach JA) J Mol Cell Cardiol 2022 Feb;163:9-19 PMID: 34610340 PMCID: PMC8816866 SCOPUS ID: 2-s2.0-85116932867 10/06/2021 15 Citations

Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes. (Wang X, Lupton C, Lauth A, Wan TC, Foster P, Patterson M, Auchampach JA, Lough JW) J Mol Cell Cardiol 2021 Jun;155:88-98 PMID: 33609538 PMCID: PMC8154663 SCOPUS ID: 2-s2.0-85102458794 02/21/2021 12 Citations

Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites. (Wang X, Lauth A, Wan TC, Lough JW, Auchampach JA) Dis Model Mech 2020 Dec 18;13(12) PMID: 33106234 PMCID: PMC7758623 SCOPUS ID: 2-s2.0-85098138727 10/28/2020 17 Citations

Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome. (Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A) Front Cell Dev Biol 2020;8:440 PMID: 32656206 PMCID: PMC7324479 SCOPUS ID: 2-s2.0-85087475806 07/14/2020 39 Citations

Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome (Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A) Frontiers in Cell and Developmental Biology 23 June 2020;8 SCOPUS ID: 2-s2.0-85087475806 06/23/2020 39 Citations

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. (Numata A, Kwok HS, Zhou QL, Li J, Tirado-Magallanes R, Angarica VE, Hannah R, Park J, Wang CQ, Krishnan V, Rajagopalan D, Zhang Y, Zhou S, Welner RS, Osato M, Jha S, Bohlander SK, Göttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG) Blood 2020 Oct 08;136(15):1735-1747 PMID: 32542325 PMCID: PMC7544546 SCOPUS ID: 2-s2.0-85092749723 06/17/2020 32 Citations

Impact of MYH6 variants in hypoplastic left heart syndrome. (Tomita-Mitchell A, Stamm KD, Mahnke DK, Kim MS, Hidestrand PM, Liang HL, Goetsch MA, Hidestrand M, Simpson P, Pelech AN, Tweddell JS, Benson DW, Lough JW, Mitchell ME) Physiol Genomics 2016 Dec 01;48(12):912-921 PMID: 27789736 PMCID: PMC5206387 SCOPUS ID: 2-s2.0-85006309110 10/30/2016 74 Citations

Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality. (Fisher JB, Horst A, Wan T, Kim MS, Auchampach J, Lough J) PLoS One 2016;11(10):e0164855 PMID: 27768769 PMCID: PMC5074524 SCOPUS ID: 2-s2.0-84992386888 10/22/2016 19 Citations

Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. (Kim MS, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J) PLoS One 2015;10(2):e0118670 PMID: 25706534 PMCID: PMC4338295 SCOPUS ID: 2-s2.0-84923332744 02/24/2015 32 Citations

Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo. (Gao Y, Hamers N, Rakhshandehroo M, Berger R, Lough J, Kalkhoven E) PLoS One 2014;9(5):e98343 PMID: 24870614 PMCID: PMC4037199 SCOPUS ID: 2-s2.0-84901641867 05/30/2014 3 Citations

Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. (Xiao Y, Nagai Y, Deng G, Ohtani T, Zhu Z, Zhou Z, Zhang H, Ji MQ, Lough JW, Samanta A, Hancock WW, Greene MI) Cell Rep 2014 Jun 12;7(5):1471-1480 PMID: 24835996 PMCID: PMC4064594 SCOPUS ID: 2-s2.0-84902332541 05/20/2014 97 Citations

Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling. (Chevillard-Briet M, Quaranta M, Grézy A, Mattera L, Courilleau C, Philippe M, Mercier P, Corpet D, Lough J, Ueda T, Fukunaga R, Trouche D, Escaffit F) Hum Mol Genet 2014 Apr 15;23(8):2120-31 PMID: 24287617 SCOPUS ID: 2-s2.0-84897902588 11/30/2013 26 Citations

Comparison of cardiomyogenic potential among human ESC and iPSC lines. (Sepac A, Si-Tayeb K, Sedlic F, Barrett S, Canfield S, Duncan SA, Bosnjak ZJ, Lough JW) Cell Transplant 2012;21(11):2523-30 PMID: 22863088 PMCID: PMC3522765 SCOPUS ID: 2-s2.0-84871578911 08/07/2012 34 Citations

Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes. (Fisher JB, Kim MS, Blinka S, Ge ZD, Wan T, Duris C, Christian D, Twaroski K, North P, Auchampach J, Lough J) PLoS One 2012;7(2):e31569 PMID: 22348108 PMCID: PMC3279378 SCOPUS ID: 2-s2.0-84863165939 02/22/2012 18 Citations

Induction of cardiomyogenesis in human embryonic stem cells by human embryonic stem cell-derived definitive endoderm. (Van Orman JR, Si-Tayeb K, Duncan SA, Lough J) Stem Cells Dev 2012 Apr 10;21(6):987-94 PMID: 21627569 PMCID: PMC3315759 SCOPUS ID: 2-s2.0-84859414013 06/02/2011 3 Citations

Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. (Gehrking KM, Andresen JM, Duvick L, Lough J, Zoghbi HY, Orr HT) Hum Mol Genet 2011 Jun 01;20(11):2204-12 PMID: 21427130 PMCID: PMC3090197 SCOPUS ID: 2-s2.0-79956017557 03/24/2011 56 Citations

Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells. (Sepac A, Sedlic F, Si-Tayeb K, Lough J, Duncan SA, Bienengraeber M, Park F, Kim J, Bosnjak ZJ) Anesthesiology 2010 Oct;113(4):906-16 PMID: 20823757 PMCID: PMC2945423 SCOPUS ID: 2-s2.0-77957904668 09/09/2010 46 Citations

Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. (Si-Tayeb K, Noto FK, Sepac A, Sedlic F, Bosnjak ZJ, Lough JW, Duncan SA) BMC Dev Biol 2010 Aug 03;10:81 PMID: 20682060 PMCID: PMC2923111 SCOPUS ID: 2-s2.0-77955118962 08/05/2010 195 Citations

Altered cardiac function and ventricular septal defect in avian embryos exposed to low-dose trichloroethylene. (Rufer ES, Hacker TA, Flentke GR, Drake VJ, Brody MJ, Lough J, Smith SM) Toxicol Sci 2010 Feb;113(2):444-52 PMID: 19910388 PMCID: PMC2807037 SCOPUS ID: 2-s2.0-75249103978 11/17/2009 39 Citations

Making stem cells infarct avid. (Zhao M, Barron MR, Li Z, Koprowski S, Hall CL, Lough J) Cell Transplant 2010;19(2):245-50 PMID: 19878624 SCOPUS ID: 2-s2.0-77951444693 11/03/2009 7 Citations

Homozygous disruption of the Tip60 gene causes early embryonic lethality. (Hu Y, Fisher JB, Koprowski S, McAllister D, Kim MS, Lough J) Dev Dyn 2009 Nov;238(11):2912-21 PMID: 19842187 PMCID: PMC2801416 SCOPUS ID: 2-s2.0-70350743144 10/21/2009 101 Citations

Myocardial interstitial fluid inhibits proliferation and cardiomyocyte differentiation in pluripotent embryonic stem cells. (Van Orman JR, Weihrauch D, Warltier DC, Lough J) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1369-76 PMID: 19633209 PMCID: PMC2770771 SCOPUS ID: 2-s2.0-70349610458 07/28/2009 1 Citation

Rapid single-step separation of pluripotent mouse embryonic stem cells from mouse feeder fibroblasts. (Li Z, Barron MR, Lough J, Zhao M) Stem Cells Dev 2008 Apr;17(2):383-7 PMID: 18447652 SCOPUS ID: 2-s2.0-43049149421 05/02/2008 8 Citations

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. (Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B) Nature 2007 Aug 30;448(7157):1063-7 PMID: 17728759 SCOPUS ID: 2-s2.0-34548312368 08/31/2007 296 Citations

Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells. (Nelson TJ, Ge ZD, Van Orman J, Barron M, Rudy-Reil D, Hacker TA, Misra R, Duncan SA, Auchampach JA, Lough JW) Anat Rec A Discov Mol Cell Evol Biol 2006 Nov;288(11):1216-24 PMID: 17004246 PMCID: PMC2566533 SCOPUS ID: 2-s2.0-33750532546 09/28/2006 56 Citations

Cardiogenic effects of trichloroethylene and trichloroacetic acid following exposure during heart specification of avian development. (Drake VJ, Koprowski SL, Hu N, Smith SM, Lough J) Toxicol Sci 2006 Nov;94(1):153-62 PMID: 16917067 SCOPUS ID: 2-s2.0-33749626274 08/19/2006 41 Citations

Erratum: Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor (Journal of Biological Chemistry (2006) 281, (15082-15089)) (Kim MS, Merlo X, Wilson C, Lough J) Journal of Biological Chemistry 28 July 2006;281(30):21576 SCOPUS ID: 2-s2.0-33746351058 07/28/2006

Introduction to special issue: Anatomy of the nucleus, based on proceedings of the anatomical record symposium held at EB2005 in San Diego, California, on 4 April 2005 (Lough J) Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology July 2006;288(7):663 SCOPUS ID: 2-s2.0-33745752100 07/01/2006

Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo. (Drake VJ, Koprowski SL, Lough J, Hu N, Smith SM) Environ Health Perspect 2006 Jun;114(6):842-7 PMID: 16759982 PMCID: PMC1480523 SCOPUS ID: 2-s2.0-33745041711 06/09/2006 46 Citations

Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. (Kim MS, Merlo X, Wilson C, Lough J) J Biol Chem 2006 Jun 02;281(22):15082-9 PMID: 16597624 SCOPUS ID: 2-s2.0-33744956273 04/07/2006 14 Citations

Gastrulating chick embryo as a model for evaluating teratogenicity: a comparison of three approaches. (Drake VJ, Koprowski SL, Lough JW, Smith SM) Birth Defects Res A Clin Mol Teratol 2006 Jan;76(1):66-71 PMID: 16333841 SCOPUS ID: 2-s2.0-32444440237 12/08/2005 41 Citations

Complete and rapid switch from light microscopy to virtual microscopy for teaching medical histology. (Krippendorf BB, Lough J) Anat Rec B New Anat 2005 Jul;285(1):19-25 PMID: 16032757 SCOPUS ID: 2-s2.0-23344441721 07/21/2005 145 Citations

Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. (Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ) J Biol Chem 2005 Mar 25;280(12):11816-28 PMID: 15591049 SCOPUS ID: 2-s2.0-20144374695 12/14/2004 43 Citations

Avian precardiac endoderm/mesoderm induces cardiac myocyte differentiation in murine embryonic stem cells. (Rudy-Reil D, Lough J) Circ Res 2004 Jun 25;94(12):e107-16 PMID: 15192018 SCOPUS ID: 2-s2.0-14944382560 06/12/2004 46 Citations

Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. (Flentke GR, Baker MW, Docterman KE, Power S, Lough J, Smith SM) Dev Dyn 2004 Apr;229(4):886-98 PMID: 15042712 SCOPUS ID: 2-s2.0-1842457037 03/26/2004 15 Citations

What's hot in anatomy: hematopoietic progenitor cells and myocardial repair. (Lough JW) Anat Rec B New Anat 2003 Sep;274(1):147 PMID: 12964204 SCOPUS ID: 2-s2.0-0141927140 09/10/2003

Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. (Wendler CC, Schmoldt A, Flentke GR, Case LC, Quadro L, Blaner WS, Lough J, Smith SM) Circ Res 2003 May 02;92(8):920-8 PMID: 12663486 PMCID: PMC3752713 SCOPUS ID: 2-s2.0-0038304602 03/29/2003 33 Citations

Inhibition of the cardiac alpha-actin gene in embryonic cardiac myocytes by dominant-negative serum response factor. (Zhu X, McAllister D, Lough J) Anat Rec A Discov Mol Cell Evol Biol 2003 Apr;271(2):315-21 PMID: 12629674 SCOPUS ID: 2-s2.0-0141994725 03/12/2003 2 Citations

Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene. (McAllister D, Merlo X, Lough J) Gene 2002 May 01;289(1-2):169-76 PMID: 12036595 SCOPUS ID: 2-s2.0-0036572275 05/31/2002 30 Citations

Transient expression of TIP60 protein during early chick heart development. (Lough JW) Dev Dyn 2002 Mar;223(3):419-25 PMID: 11891991 SCOPUS ID: 2-s2.0-0036197856 03/14/2002 17 Citations

FGF-2-induced imbalance in early embryonic heart cell proliferation: a potential cause of late cardiovascular anomalies. (Franciosi JP, Bolender DL, Lough J, Kolesari GL) Teratology 2000 Oct;62(4):189-94 PMID: 10992260 SCOPUS ID: 2-s2.0-0033808998 09/19/2000 11 Citations

Differential expression of cSmad1 and cSmad5 in the primitive streak during chick embryo gastrulation. (Gont L, Lough J) Anat Rec 2000 Sep 01;260(1):102-5 PMID: 10967541 SCOPUS ID: 2-s2.0-0034282940 09/01/2000 3 Citations

Requirement for BMP and FGF signaling during cardiogenic induction in non-precardiac mesoderm is specific, transient, and cooperative. (Barron M, Gao M, Lough J) Dev Dyn 2000 Jun;218(2):383-93 PMID: 10842364 SCOPUS ID: 2-s2.0-0034093126 06/08/2000 146 Citations

Endoderm and heart development. (Lough J, Sugi Y) Dev Dyn 2000 Apr;217(4):327-42 PMID: 10767078 SCOPUS ID: 2-s2.0-0034111134 04/15/2000 201 Citations

Evidence that FGF receptor signaling is necessary for endoderm-regulated development of precardiac mesoderm. (Zhu X, Sasse J, Lough J) Mech Ageing Dev 1999 Apr 01;108(1):77-85 PMID: 10366041 SCOPUS ID: 2-s2.0-0033119062 06/12/1999 18 Citations

Expression of retinol binding protein and transthyretin during early embryogenesis. (Barron M, McAllister D, Smith SM, Lough J) Dev Dyn 1998 Jul;212(3):413-22 PMID: 9671945 SCOPUS ID: 2-s2.0-0031750873 07/22/1998 23 Citations

Teratogenic effects of implanting fibroblast growth factor-2-soaked beads in the cardiac region of the stage 24 chick embryo. (Watkins BP, Bolender DL, Lough J, Kolesari GL) Teratology 1998 Mar;57(3):140-5 PMID: 9587967 SCOPUS ID: 2-s2.0-0031946950 05/20/1998 1 Citation

Evidence that fibroblast growth factors 1 and 4 participate in regulation of cardiogenesis. (Zhu X, Sasse J, McAllister D, Lough J) Dev Dyn 1996 Dec;207(4):429-38 PMID: 8950517 SCOPUS ID: 2-s2.0-0029860034 12/01/1996 60 Citations

Insulin-like growth factor-II/mannose-6-phosphate receptor expression during early heart development. (McCormick KM, Dahms NM, Lough J) Dev Dyn 1996 Oct;207(2):195-203 PMID: 8906422 SCOPUS ID: 2-s2.0-0029853236 10/01/1996 8 Citations

Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. (Lough J, Barron M, Brogley M, Sugi Y, Bolender DL, Zhu X) Dev Biol 1996 Aug 25;178(1):198-202 PMID: 8812122 SCOPUS ID: 2-s2.0-0030601359 08/25/1996 195 Citations

Avian serum response factor expression restricted primarily to muscle cell lineages is required for alpha-actin gene transcription. (Croissant JD, Kim JH, Eichele G, Goering L, Lough J, Prywes R, Schwartz RJ) Dev Biol 1996 Jul 10;177(1):250-64 PMID: 8660892 SCOPUS ID: 2-s2.0-0030578427 07/10/1996 157 Citations

Expression of alternatively spliced and canonical basic fibroblast growth factor mRNAs in the early embryo and developing heart. (Zhu X, Lough J) Dev Dyn 1996 Jun;206(2):139-45 PMID: 8725281 SCOPUS ID: 2-s2.0-0029999250 06/01/1996 12 Citations

Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis in vitro. (Sugi Y, Lough J) Dev Biol 1995 Apr;168(2):567-74 PMID: 7729588 SCOPUS ID: 2-s2.0-0028905441 04/01/1995 121 Citations

Developmental expression of fibroblast growth factor receptor-1 (cek-1; flg) during heart development. (Sugi Y, Sasse J, Barron M, Lough J) Dev Dyn 1995 Feb;202(2):115-25 PMID: 7734730 SCOPUS ID: 2-s2.0-0028796767 02/01/1995 53 Citations

Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region. (Sugi Y, Lough J) Dev Dyn 1994 Jun;200(2):155-62 PMID: 7919501 SCOPUS ID: 2-s2.0-0028292426 06/01/1994 129 Citations

Inhibition of precardiac mesoderm cell proliferation by antisense oligodeoxynucleotide complementary to fibroblast growth factor-2 (FGF-2). (Sugi Y, Sasse J, Lough J) Dev Biol 1993 May;157(1):28-37 PMID: 8482417 SCOPUS ID: 2-s2.0-0027238422 05/01/1993 86 Citations

Onset of expression and regional deposition of alpha-smooth and sarcomeric actin during avian heart development. (Sugi Y, Lough J) Dev Dyn 1992 Feb;193(2):116-24 PMID: 1581600 SCOPUS ID: 2-s2.0-0026521724 02/01/1992 58 Citations

Localization of bFGF-like proteins as punctate inclusions in the preseptation myocardium of the chicken embryo. (Parlow MH, Bolender DL, Kokan-Moore NP, Lough J) Dev Biol 1991 Jul;146(1):139-47 PMID: 1647988 SCOPUS ID: 2-s2.0-0025812005 07/01/1991 72 Citations

Secretion of inhibin beta A by endoderm cultured from early embryonic chicken. (Kokan-Moore NP, Bolender DL, Lough J) Dev Biol 1991 Jul;146(1):242-5 PMID: 2060706 SCOPUS ID: 2-s2.0-0025762279 07/01/1991 38 Citations

Normal transitions in synthesis of replacement histones H2A.Z and H3.3 during differentiation of dystrophic myotube cells. A brief note. (Wunsch AM, Reinhardt K, Lough J) Mech Ageing Dev 1991 Jun 28;59(3):299-305 PMID: 1921519 SCOPUS ID: 2-s2.0-0025912482 06/28/1991 9 Citations

Affinity isolation of active murine erythroleukemia cell chromatin: uniform distribution of ubiquitinated histone H2A between active and inactive fractions. (Dawson BA, Herman T, Haas AL, Lough J) J Cell Biochem 1991 Jun;46(2):166-73 PMID: 1655820 SCOPUS ID: 2-s2.0-0025904349 06/01/1991 24 Citations

Arabinosylcytosine-induced accumulation of DNA nicks in myotube nuclei detected by in situ nick translation. (Masuck TM, Taylor AR, Lough J) J Cell Physiol 1990 Jul;144(1):12-7 PMID: 2365739 SCOPUS ID: 2-s2.0-0025316415 07/01/1990 13 Citations

Enrichment of ubiquitinated histone H2A in a low salt extract of micrococcal nuclease-digested myotube nuclei. (Parlow MH, Haas AL, Lough J) J Biol Chem 1990 May 05;265(13):7507-12 PMID: 2159002 SCOPUS ID: 2-s2.0-0025344438 05/05/1990 19 Citations

Histone variant patterns during vertebrate embryogenesis and limb development. (Wunsch AM, Lough J) Cell Differ Dev 1990 Apr;30(1):19-25 PMID: 2350733 SCOPUS ID: 2-s2.0-0025283787 04/01/1990 9 Citations

A Culture Model for Cardiac Morphogenesis (LOUGH JW, BOLENDER DL, MARKWALD RR) Annals of the New York Academy of Sciences April 1990;588(1):421-424 SCOPUS ID: 2-s2.0-0025376370 01/01/1990 16 Citations

Histones synthesized at different stages of myogenesis are differentially degraded in myotube cells. (Wunsch AM, Lough J) J Cell Physiol 1989 Oct;141(1):97-102 PMID: 2777905 SCOPUS ID: 2-s2.0-0024440726 10/01/1989 11 Citations

Affinity isolation of transcriptionally active murine erythroleukemia cell DNA using a cleavable biotinylated nucleotide analog. (Dawson BA, Herman T, Lough J) J Biol Chem 1989 Aug 05;264(22):12830-7 PMID: 2753891 SCOPUS ID: 2-s2.0-0024389329 08/05/1989 9 Citations

Immunocytochemical localization of transient DNA strand breaks in differentiating myotubes using in situ nick-translation. (Dawson BA, Lough J) Dev Biol 1988 Jun;127(2):362-7 PMID: 3378668 SCOPUS ID: 2-s2.0-0023904340 06/01/1988 42 Citations

Synthesis and ubiquitination of histones during myogenesis. (Wunsch AM, Haas AL, Lough J) Dev Biol 1987 Jan;119(1):85-93 PMID: 3025034 SCOPUS ID: 2-s2.0-0023103138 01/01/1987 29 Citations

Modulation of histone H3 variant synthesis during the myoblast-myotube transition of chicken myogenesis. (Wunsch AM, Lough J) Dev Biol 1987 Jan;119(1):94-9 PMID: 3792638 SCOPUS ID: 2-s2.0-0023118959 01/01/1987 32 Citations

Affinity isolation of transcriptionally active DNA. (Roseman B, Lough J, Houkom E, Herman T) Biochem Biophys Res Commun 1986 May 29;137(1):474-9 PMID: 3718516 SCOPUS ID: 2-s2.0-0022506841 05/29/1986 9 Citations

Interferon-mediated inhibition of differentiation in a murine myoblast cell line. (Multhauf C, Lough J) J Cell Physiol 1986 Feb;126(2):211-5 PMID: 3944205 SCOPUS ID: 2-s2.0-0022631655 02/01/1986 15 Citations

Differential sensitivity of chicken MM-creatine kinase to trypsin and proteinase-K. (Lough J, Wrenn DS, Miziorko HM, Auer HE) Int J Biochem 1985;17(3):309-18 PMID: 3891449 SCOPUS ID: 2-s2.0-0021840560 01/01/1985 11 Citations

Spermine-induced phosphorylation of myotube histones by endogenous nuclear protein kinases. (Lough J) Exp Cell Res 1984 Jan;150(1):23-8 PMID: 6692846 SCOPUS ID: 2-s2.0-0021353433 01/01/1984 6 Citations

One and two-dimensional electrophoretic assessment of histone synthesis in differentiating G(o) myotube cells (Wunsch AM, Lough J) Federation Proceedings 1984;43(6) SCOPUS ID: 2-s2.0-17644444437 01/01/1984

Declining histone phosphorylation during myogenesis revealed by in vivo and in vitro labeling. (Lough J) Exp Cell Res 1983 Oct 15;148(2):437-47 PMID: 6628565 SCOPUS ID: 2-s2.0-0021016772 10/15/1983 7 Citations

Modulation of in vitro myogenesis by submillimolar concentrations of sodium butyrate. (Lough J) Cell Differ 1983 Jan;12(1):41-6 PMID: 6825176 SCOPUS ID: 2-s2.0-0020699251 01/01/1983 1 Citation

Inhibition of chicken myogenesis in vitro by partially purified interferon. (Lough J, Keay S, Sabran JL, Grossberg SE) Biochem Biophys Res Commun 1982 Nov 16;109(1):92-9 PMID: 6186251 SCOPUS ID: 2-s2.0-0020308771 11/16/1982 16 Citations

DNA synthesis and accumulation of acetylated histone in butyrate-treated myogenic cultures. (Lough J) Cell Biol Int Rep 1981 Jul;5(7):691-8 PMID: 6168401 SCOPUS ID: 2-s2.0-0019468931 07/01/1981 2 Citations

Muscle specific traits display differential sensitivity to 5-bromo-2'-deoxyuridine. (Lough J) Cell Differ 1980 Oct;9(5):247-60 PMID: 7438210 SCOPUS ID: 2-s2.0-0018957842 10/01/1980 4 Citations

Effects of sodium buytrate on histone modification and differentiation in cultured myoblasts (Lough J) European Journal of Cell Biology 1980;22(1):G232 SCOPUS ID: 2-s2.0-0019194368 01/01/1980

Interferon inhibits the creatine kinase (CK) isozyme transition during in vitro myogenesis (Keay S, Lough J, Grossberg SE) Anatomical Record 1980;196(3) SCOPUS ID: 2-s2.0-0018938973 01/01/1980

Change in a nuclear phosphoprotein during in vitro myogenesis. (Lough J, Ingram VM) Exp Cell Res 1978 Jul;114(2):349-56 PMID: 679987 SCOPUS ID: 2-s2.0-0018101559 07/01/1978 11 Citations

Differentiation of creatine phosphokinase during myogenesis: quantitative fractionation of isozymes. (Lough J, Bischoff R) Dev Biol 1977 Jun;57(2):330-44 PMID: 559598 SCOPUS ID: 2-s2.0-0017713095 06/01/1977 61 Citations

Differential sensitivity to 5-bromodeoxyuridine during the S phase of synchronized myogenic cells. (Lough J, Bischoff R) Dev Biol 1976 Jun;50(2):457-75 PMID: 1278597 SCOPUS ID: 2-s2.0-0017143247 06/01/1976 29 Citations

Effect of 5' bromodeoxyuridine concentration on the emergence of muscle specific parameters during myogenesis in vitro (Lough J, Bischoff R) Anatomical Record 1975;181(2):413 SCOPUS ID: 2-s2.0-0016658974 01/01/1975

The effects of chloroquine on chick skeletal muscle in vitro. (Bossen EH, Lough JW Jr, Hansen JL) Toxicol Appl Pharmacol 1973 Feb;24(2):197-205 PMID: 4696304 SCOPUS ID: 2-s2.0-0015583006 02/01/1973 3 Citations

Calcium accumulation by isolated sarcoplasmic reticulum of skeletal muscle during development in tissue culture. (Lough JW, Entman ML, Bossen EH, Hansen JL) J Cell Physiol 1972 Dec;80(3):431-6 PMID: 4265139 SCOPUS ID: 2-s2.0-0015466397 12/01/1972 9 Citations

Physiology of the large milkweed bug after laser irradiation. (Feir D, Lough JW Jr) Comp Biochem Physiol 1969 Feb;28(2):759-64 PMID: 5778263 SCOPUS ID: 2-s2.0-0014470303 02/01/1969 2 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

John W. Lough PhD, MS

Emeritus Professor

Publications (98)