Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Juliana Perez Botero MD

Juliana Perez Botero MD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology - Medicine
Program: Benign Hematology

Member of the Mellowes Center for Genomic Sciences and Precision Medicine


I am willing to collaborate on research projects.
I am willing to mentor a junior faculty member.

View Curriculum Vitae

Research Areas of Interest

  • Blood Coagulation Disorders, Inherited
  • Blood Platelet Disorders
  • Data Curation
  • Genetic Testing
  • Pregnancy Complications, Hematologic

    • Research Experience

  • Blood Platelet Disorders
  • Medical Laboratory Science
  • Platelet Function Tests
  • Venous Thromboembolism

    • Clinical Expertise

  • Hematology
  • Medical Laboratory Science
  • Pregnancy Complications, Hematologic

    • Methodologies and Techniques

  • Genetic Testing

    • Leadership Positions

  • MCW LGBTQ+ Employee Resource Group Co-Chair 2020-2023
  • Versiti D&I council member

    • MCW Program / Core Facilities

  • Division of Hematology and Oncology

    • Publications (47)

  • Evaluating the clinical validity of genes related to hemostasis and thrombosis using the Clinical Genome Resource gene curation framework. (Ross JE, Mohan S, Zhang J, Sullivan MJ, Bury L, Lee K, Futchi I, Frantz A, McDougal D, Perez Botero J, Cattaneo M, Cooper N, Downes K, Gresele P, Keenan C, Lee AI, Megy K, Morange PE, Morgan NV, Schulze H, Zimowski K, Freson K, Lambert MP) J Thromb Haemost 2024 Mar;22(3):645-665 PMID: 38016518 PMCID: PMC10922649 SCOPUS ID: 2-s2.0-85180598714 11/29/2023    
  • What to expect when an ITP patient is expecting. (Perez Botero J) Blood 2023 Jan 05;141(1):3-4 PMID: 36602822 SCOPUS ID: 2-s2.0-85145297699 01/06/2023    
  • Peripartum management of deep venous thrombosis in the context of antithrombin deficiency and May-Thurner syndrome. (Stevens-Haas CL, Livergood MC, Perez Botero J, McIntosh JJ) Blood Coagul Fibrinolysis 2023 Apr 01;34(3):211-214 PMID: 36440804 PMCID: PMC10089933 SCOPUS ID: 2-s2.0-85152172814 11/29/2022    
  • ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms. (Sullivan MJ, Palmer EL, Botero JP) Curr Hematol Malig Rep 2022 Oct;17(5):105-112 PMID: 35751752 SCOPUS ID: 2-s2.0-85132834506 06/26/2022       9 Citations
  • CD36 immunization causing platelet transfusion refractoriness: narrative review (Sullivan M, Perez Botero J ) Annals of Blood Annals Of Blood, 6. doi:10.21037/aob-21-36 12/30/2021    
  • Severe thrombocytopenia and microangiopathic hemolytic anemia in pregnancy: A guide for the consulting hematologist. (Perez Botero J, Reese JA, George JN, McIntosh JJ) Am J Hematol 2021 Dec 01;96(12):1655-1665 PMID: 34424560 PMCID: PMC8616841 SCOPUS ID: 2-s2.0-85114193939 08/24/2021       15 Citations
  • GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. (Megy K, Downes K, Morel-Kopp MC, Bastida JM, Brooks S, Bury L, Leinoe E, Gomez K, Morgan NV, Othman M, Ouwehand WH, Perez Botero J, Rivera J, Schulze H, Trégouët DA, Freson K) J Thromb Haemost 2021 Oct;19(10):2612-2617 PMID: 34355501 PMCID: PMC9291976 SCOPUS ID: 2-s2.0-85111866177 08/07/2021       20 Citations
  • Diagnostic approach to the patient with a suspected inherited platelet disorder: Who and how to test. (Perez Botero J, Di Paola J) J Thromb Haemost 2021 Sep;19(9):2127-2136 PMID: 34347927 SCOPUS ID: 2-s2.0-85112365184 08/05/2021       5 Citations
  • Recognition of the unique bleeding pattern and laboratory findings in acquired haemophilia A facilitates prompt treatment of a life-threatening disorder. (Cameron H, Perez Botero J) BMJ Case Rep 2021 Aug 03;14(8) PMID: 34344656 PMCID: PMC8336148 SCOPUS ID: 2-s2.0-85112098959 08/05/2021       1 Citation
  • The Society for Obstetric Anesthesia and Perinatology Interdisciplinary Consensus Statement on Neuraxial Procedures in Obstetric Patients With Thrombocytopenia. (Bauer ME, Arendt K, Beilin Y, Gernsheimer T, Perez Botero J, James AH, Yaghmour E, Toledano RD, Turrentine M, Houle T, MacEachern M, Madden H, Rajasekhar A, Segal S, Wu C, Cooper JP, Landau R, Leffert L) Anesth Analg 2021 Jun 01;132(6):1531-1544 PMID: 33861047 SCOPUS ID: 2-s2.0-85106203904 04/17/2021       55 Citations
  • Gray Platelet Syndrome Presenting With Pancytopenia, Splenomegaly, and Bone Marrow Fibrosis. (Tariq H, Perez Botero J, Higgins RA, Medina EA) Am J Clin Pathol 2021 Jul 06;156(2):253-258 PMID: 33586768 SCOPUS ID: 2-s2.0-85104606599 02/16/2021       5 Citations
  • Specifications of the variant curation guidelines for ITGA2B/ITGB3: ClinGen Platelet Disorder Variant Curation Panel. (Ross JE, Zhang BM, Lee K, Mohan S, Branchford BR, Bray P, Dugan SN, Freson K, Heller PG, Kahr WHA, Lambert MP, Luchtman-Jones L, Luo M, Perez Botero J, Rondina MT, Ryan G, Westbury S, Bergmeier W, Di Paola J) Blood Adv 2021 Jan 26;5(2):414-431 PMID: 33496739 PMCID: PMC7839359 SCOPUS ID: 2-s2.0-85099863862 01/27/2021       19 Citations
  • Glanzmann thrombasthenia: genetic basis and clinical correlates. (Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J, ClinGen Platelet Disorder Variant Curation Expert Panel) Haematologica 2020 Apr;105(4):888-894 PMID: 32139434 PMCID: PMC7109743 SCOPUS ID: 2-s2.0-85083264534 03/07/2020       71 Citations
  • Apixaban and dalteparin in active malignancy-associated venous thromboembolism: The ADAM VTE trial. (McBane RD 2nd, Wysokinski WE, Le-Rademacher JG, Zemla T, Ashrani A, Tafur A, Perepu U, Anderson D, Gundabolu K, Kuzma C, Perez Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Houghton DE, Vishnu P, Loprinzi CL) J Thromb Haemost 2020 Feb;18(2):411-421 PMID: 31630479 SCOPUS ID: 2-s2.0-85075059646 10/21/2019       365 Citations
  • Phenotypic heterogeneity associated with germline GATA2 haploinsufficiency: a comprehensive kindred study. (Haddox CL, Carr RM, Abraham RS, Perez Botero J, Rodriguez V, Pardanani A, Patnaik MM) Leuk Lymphoma 2019 Dec;60(13):3282-3286 PMID: 31246134 PMCID: PMC6923578 SCOPUS ID: 2-s2.0-85068225311 06/28/2019       5 Citations
  • ANKRD26-Related Thrombocytopenia (Perez Botero J, Dugan SN, Anderson MW) GeneReviews In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. 06/21/2018    
  • Congenital Disorders of Platelet Function and Number. (Sharma R, Perez Botero J, Jobe SM) Pediatr Clin North Am 2018 Jun;65(3):561-578 PMID: 29803283 SCOPUS ID: 2-s2.0-85047384974 05/29/2018       7 Citations
  • Diagnostic considerations with inherited platelet disorder testing (Perez Botero, J ) Medical Laboratory Observer 01/25/2018    
  • Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65 year-old with oculocutaneous hypopigmentation and mild bleeding diathesis: The importance of recognizing a subtle phenotype. (Botero JP, Chen D, Majerus JA, Coon LM, He R, Warad DM, Pruthi RK, Nichols WL) Platelets 2018 Jan;29(1):91-94 PMID: 29090612 SCOPUS ID: 2-s2.0-85041104511 11/02/2017       8 Citations
  • The Impact of Antithrombin Deficiency on Women's Reproductive Health Experiences and Healthcare Decision-Making. (Marshall AL, Botero JP, Ashrani AA, Pruthi RK, Heit JA, Chintakuntlawar A, Guenther JC, Patnaik MM) J Womens Health (Larchmt) 2017 Dec;26(12):1350-1355 PMID: 28933640 SCOPUS ID: 2-s2.0-85038426315 09/22/2017    
  • Factor IX Gene (F9) Genotyping Trends and Spectrum of Mutations Identified: A Reference Laboratory Experience. (Perez Botero J, Coon LM, Majerus JA, Chen D, Pruthi RK) Semin Thromb Hemost 2018 Apr;44(3):287-292 PMID: 28905352 SCOPUS ID: 2-s2.0-85029762803 09/15/2017       2 Citations
  • Apixaban and dalteparin in active malignancy associated venous thromboembolism. The ADAM VTE Trial. (McBane Ii R, Loprinzi CL, Ashrani A, Perez-Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Le-Rademacher JG, Wysokinski WE) Thromb Haemost 2017 Oct 05;117(10):1952-1961 PMID: 28837207 SCOPUS ID: 2-s2.0-85031103657 08/25/2017       67 Citations
  • Comprehensive Platelet Phenotypic Laboratory Testing and Bleeding History Scoring for Diagnosis of Suspected Hereditary Platelet Disorders: A Single-Institution Experience. (Perez Botero J, Warad DM, He R, Uhl CB, Tian S, Otteson GE, Barness RL, Olson MC, Gossman SC, Charlesworth JE, Nichols WL, Pruthi RK, Chen D) Am J Clin Pathol 2017 Jul 01;148(1):23-32 PMID: 28575217 SCOPUS ID: 2-s2.0-85028973859 06/03/2017       13 Citations
  • Coagulation abnormalities and haemostatic surgical outcomes in 142 patients with Noonan syndrome. (Perez Botero J, Ho TP, Rodriguez V, Khan SP, Pruthi RK, Patnaik MM) Haemophilia 2017 May;23(3):e237-e240 PMID: 28520208 SCOPUS ID: 2-s2.0-85019554482 05/19/2017       11 Citations
  • Clinical spectrum and clonal evolution in germline syndromes with predisposition to myeloid neoplasms. (Perez Botero J, Ho TP, Hogan WJ, Kenderian S, Gangat N, Tefferi A, Abraham RS, Nguyen P, Oliveira JL, He R, Chen D, Viswanatha D, Rodriguez V, Khan SP, Patnaik MM) Br J Haematol 2018 Jul;182(1):141-145 PMID: 28485484 SCOPUS ID: 2-s2.0-85019092922 05/10/2017       4 Citations
  • Diagnostic Testing Approaches for Activated Protein C Resistance and Factor V Leiden: A Comparison of Institutional and National Provider Practices. (Perez Botero J, Majerus JA, Strege AK, Johnson RD, Chen D, Pruthi RK) Am J Clin Pathol 2017 Jun 01;147(6):604-610 PMID: 28472350 SCOPUS ID: 2-s2.0-85031667857 05/05/2017       7 Citations
  • Von Willebrand Disease. The 5-Minute Clinical Consult (Perez Botero J, Wysokinska EM, Ashrani AA) The 5-Minute Clinical Consult. Twenty-Sixth Edition, 2018. Wolter Kluwer Health. ISBN 9781496374622 05/03/2017    
  • Primary Lymphedema and Viral Warts in GATA2 Haploinsufficiency. (Perez Botero J, Rodriguez V) Mayo Clin Proc 2017 Mar;92(3):482 PMID: 28259234 SCOPUS ID: 2-s2.0-85014107351 03/06/2017       4 Citations
  • Clinical characteristics and platelet phenotype in a family with RUNX1 mutated thrombocytopenia. (Perez Botero J, Chen D, Cousin MA, Majerus JA, Coon LM, Kruisselbrink TM, Klee EW, Lazaridis KN, Pruthi RK, Patnaik MM) Leuk Lymphoma 2017 Aug;58(8):1963-1967 PMID: 27931139 SCOPUS ID: 2-s2.0-85003977139 12/10/2016       10 Citations
  • A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome. (Jatoi A, Grudem ME, Dockter TJ, Block MS, Villasboas JC, Tan A, Deering E, Kasi PM, Mansfield AS, Botero JP, Okuno SH, Smith DR, Fields AP) Support Care Cancer 2017 Mar;25(3):833-838 PMID: 27838777 PMCID: PMC5269609 SCOPUS ID: 2-s2.0-84994691896 11/14/2016       7 Citations
  • Clinical and laboratory characteristics in congenital ANKRD26 mutation-associated thrombocytopenia: A detailed phenotypic study of a family. (Perez Botero J, Chen D, He R, Viswanatha DS, Majerus JA, Coon LM, Nguyen PL, Reichard KK, Oliveira JL, Tefferi A, Gangat N, Pruthi RK, Patnaik MM) Platelets 2016 Nov;27(7):712-715 PMID: 27123948 SCOPUS ID: 2-s2.0-84964490706 11/05/2016       17 Citations
  • A Novel Case Management System to Address Patient-Identified Concerns in Hematology and Oncology Clinical Pathways (Warsame R., Hubbard J., Thompson C.A., Croghan K., Tan A., Fruth B., Perez Botero J., Pachman D., Lafky V., Dispenzieri A., Sloan J) Journal of Clinical Pathways 10/01/2016    
  • Practice patterns in the diagnosis of inherited platelet disorders within a single institution. (Perez Botero J, Pruthi RK, Majerus JA, Coon LM, Uhl CB, Chen D, Patnaik MM) Blood Coagul Fibrinolysis 2017 Jun;28(4):303-308 PMID: 27607598 SCOPUS ID: 2-s2.0-84986203493 09/09/2016       4 Citations
  • Delayed diagnosis of MYH-9–related disorder and the role of light microscopy in congenital macrothrombocytopenias. (Perez Botero J, Patnaik MM) Blood 2016 Apr 14;127(15):1940 PMID: 27540618 SCOPUS ID: 2-s2.0-84963740261 08/20/2016       5 Citations
  • Capturing and Incorporating Patient-Reported Outcomes into Clinical Trials: Practical Considerations for Clinicians. (Botero JP, Thanarajasingam G, Warsame R) Curr Oncol Rep 2016 Oct;18(10):61 PMID: 27525737 SCOPUS ID: 2-s2.0-84982266796 08/16/2016       7 Citations
  • Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group. (Go RS, Winters JL, Leung N, Murray DL, Willrich MA, Abraham RS, Amer H, Hogan WJ, Marshall AL, Sethi S, Tran CL, Chen D, Pruthi RK, Ashrani AA, Fervenza FC, Cramer CH 2nd, Rodriguez V, Wolanskyj AP, Thomé SD, Hook CC, Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy Disease-Oriented Group) Mayo Clin Proc 2016 Sep;91(9):1189-211 PMID: 27497856 SCOPUS ID: 2-s2.0-84990895538 08/09/2016       52 Citations
  • Fanconi Anemia-Protean Manifestations of Defective DNA Repair. (Perez Botero J, Patnaik MM) Mayo Clin Proc 2016 Jun;91(6):824-5 PMID: 27261875 SCOPUS ID: 2-s2.0-84976871345 06/05/2016    
  • Grey platelet syndrome misdiagnosed as ITP. (Perez Botero J, Im R, Chen D, Patnaik MM) Br J Haematol 2016 Jun;173(5):662 PMID: 27172068 SCOPUS ID: 2-s2.0-85000418311 05/14/2016       6 Citations
  • Do incident and recurrent venous thromboembolism risks truly differ between heterozygous and homozygous Factor V Leiden carriers? A retrospective cohort study. (Perez Botero J, Ormsby WD, Ashrani AA, McBane RD 2nd, Wysokinski WE, Patnaik MM, Lewis BR, Grill DE, Pruthi RK, Heit JA) Eur J Intern Med 2016 May;30:77-81 PMID: 26970916 SCOPUS ID: 2-s2.0-84960153818 03/14/2016       5 Citations
  • von Willebrand disease type1/type 2N compound heterozygotes: diagnostic and management challenges. (Perez Botero J, Pruthi RK, Nichols WL, Ashrani AA, Patnaik MM) Br J Haematol 2017 Mar;176(6):994-997 PMID: 26970096 SCOPUS ID: 2-s2.0-84960511238 03/13/2016       3 Citations
  • Spur cell anemia in the setting of progressive liver allograft failure. (Partain DK, Botero JP, Shi M, Poterucha JJ, Ashrani AA, Thompson CA) Am J Hematol 2016 Oct;91(10):1061 PMID: 26874796 SCOPUS ID: 2-s2.0-84990183148 02/15/2016       1 Citation
  • ASXL1 mutated chronic myelomonocytic leukemia in a patient with familial thrombocytopenia secondary to germline mutation in ANKRD26. (Perez Botero J, Oliveira JL, Chen D, Reichard KK, Viswanatha DS, Nguyen PL, Pruthi RK, Majerus J, Gada P, Gangat N, Tefferi A, Patnaik MM) Blood Cancer J 2015 May 22;5(5):e315 PMID: 26001113 PMCID: PMC4476020 SCOPUS ID: 2-s2.0-84989920080 05/23/2015       33 Citations
  • Incidence of symptomatic venous thromboembolism in patients with hemophilia undergoing joint replacement surgery: a retrospective study. (Perez Botero J, Spoon DB, Patnaik MS, Ashrani AA, Trousdale RT, Pruthi RK) Thromb Res 2015 Jan;135(1):109-13 PMID: 25434629 SCOPUS ID: 2-s2.0-84922435073 12/02/2014       33 Citations
  • Refractory bleeding from intestinal angiodysplasias successfully treated with danazol in three patients with von Willebrand disease. (Botero JP, Pruthi RK) Blood Coagul Fibrinolysis 2013 Dec;24(8):884-6 PMID: 23867344 SCOPUS ID: 2-s2.0-84888137209 07/23/2013       14 Citations
  • Successful treatment with thalidomide of a patient with congenital factor V deficiency and factor V inhibitor with recurrent gastrointestinal bleeding from small bowel arteriovenous malformations. (Perez Botero J, Burns D, Thompson CA, Pruthi RK) Haemophilia 2013 Jan;19(1):e59-61 PMID: 23171429 SCOPUS ID: 2-s2.0-84871010627 11/23/2012       15 Citations
  • Preimplantation genetic diagnosis--a historical annotation: first PGD baby turns fifteen. (Perez J, Lucena E, Hughes M, Lizcano L, Kasper CK) Haemophilia 2011 Jul;17 Suppl 1:18-9 PMID: 21692924 SCOPUS ID: 2-s2.0-79959558510 07/01/2011       2 Citations
  • Update in the management of hemophilia – Online Course. Co-author of the module on hematologic perspective of hemophilia and general editor and producer of the entire course’s content. (Perez Botero J, Duarte M, Llinas A) Sponsored by Pfizer Colombia. Material produced in Spanish 04/01/2011    
    • Last update: 03/25/2024