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Medical College of Wisconsin

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Jung Ja P. Kim PhD

Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

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Publications (59)

Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases. (Narayanan B, Xia C, McAndrew R, Shen AL, Kim JP) Sci Rep 2024 Jun 05;14(1):12976 PMID: 38839792 PMCID: PMC11153573 SCOPUS ID: 2-s2.0-85195340831 06/06/2024 5 Citations

Structural Basis for Expanded Substrate Specificities of Human Long Chain Acyl-CoA Dehydrogenase and Related Acyl- CoA Dehydrogenases. (Narayanan B, Xia C, McAndrew R, Shen AL, Kim JP) Res Sq 2024 Feb 29 PMID: 38464032 PMCID: PMC10925408 03/11/2024

Molecular mechanism of interactions between ACAD9 and binding partners in mitochondrial respiratory complex I assembly. (Xia C, Lou B, Fu Z, Mohsen AW, Shen AL, Vockley J, Kim JP) iScience 2021 Oct 22;24(10):103153 PMID: 34646991 PMCID: PMC8497999 SCOPUS ID: 2-s2.0-85122672429 10/15/2021 23 Citations

Structural and kinetic investigations of the carboxy terminus of NADPH-cytochrome P450 oxidoreductase. (Hubbard PA, Xia C, Shen AL, Kim JP) Arch Biochem Biophys 2021 Apr 15;701:108792 PMID: 33556357 PMCID: PMC8020834 SCOPUS ID: 2-s2.0-85101027274 02/09/2021 7 Citations

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. (Olson LJ, Misra SK, Ishihara M, Battaile KP, Grant OC, Sood A, Woods RJ, Kim JP, Tiemeyer M, Ren G, Sharp JS, Dahms NM) Commun Biol 2020 Sep 09;3(1):498 PMID: 32908216 PMCID: PMC7481795 SCOPUS ID: 2-s2.0-85090384984 09/11/2020 25 Citations

Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase. (Xia C, Shen AL, Duangkaew P, Kotewong R, Rongnoparut P, Feix J, Kim JP) Biochemistry 2019 May 14;58(19):2408-2418 PMID: 31009206 PMCID: PMC6873807 SCOPUS ID: 2-s2.0-85065650755 04/23/2019 13 Citations

Crystal structure of human mitochondrial trifunctional protein, a fatty acid β-oxidation metabolon. (Xia C, Fu Z, Battaile KP, Kim JP) Proc Natl Acad Sci U S A 2019 Mar 26;116(13):6069-6074 PMID: 30850536 PMCID: PMC6442613 SCOPUS ID: 2-s2.0-85063953610 03/10/2019 77 Citations

Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer. (Xia C, Rwere F, Im S, Shen AL, Waskell L, Kim JP) Biochemistry 2018 Feb 13;57(6):945-962 PMID: 29308883 PMCID: PMC5967631 SCOPUS ID: 2-s2.0-85042055043 01/09/2018 15 Citations

Application of methyl-TROSY to a large paramagnetic membrane protein without perdeuteration: ¹³C-MMTS-labeled NADPH-cytochrome P450 oxidoreductase. (Galiakhmetov AR, Kovrigina EA, Xia C, Kim JP, Kovrigin EL) J Biomol NMR 2018 Jan;70(1):21-31 PMID: 29168021 PMCID: PMC5820150 SCOPUS ID: 2-s2.0-85034633089 11/24/2017 11 Citations

Conformational States of Cytochrome P450 Oxidoreductase Evaluated by Förster Resonance Energy Transfer Using Ultrafast Transient Absorption Spectroscopy. (Kovrigina EA, Pattengale B, Xia C, Galiakhmetov AR, Huang J, Kim JP, Kovrigin EL) Biochemistry 2016 Nov 01;55(43):5973-5976 PMID: 27741572 PMCID: PMC6505697 SCOPUS ID: 2-s2.0-84994050017 11/02/2016 9 Citations

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ) Mol Cell 2016 Aug 18;63(4):621-632 PMID: 27499296 PMCID: PMC4992456 SCOPUS ID: 2-s2.0-84992735863 08/09/2016 225 Citations

Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. (McCammon KM, Panda SP, Xia C, Kim JJ, Moutinho D, Kranendonk M, Auchus RJ, Lafer EM, Ghosh D, Martasek P, Kar R, Masters BS, Roman LJ) J Biol Chem 2016 Sep 23;291(39):20487-502 PMID: 27496950 PMCID: PMC5034044 SCOPUS ID: 2-s2.0-84988664489 08/09/2016 24 Citations

Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. (Rwere F, Xia C, Im S, Haque MM, Stuehr DJ, Waskell L, Kim JJ) J Biol Chem 2016 Jul 08;291(28):14639-61 PMID: 27189945 PMCID: PMC4938185 SCOPUS ID: 2-s2.0-84978958357 05/18/2016 23 Citations

Electron Transfer Partners of Cytochrome P450 (Waskell, L and Kim, J.-J. P) Cytochrome P450: Structure, Mechanism, and Biochemistry Waskell, L and Kim, J.-J. P. “ Electron Transfer Partners of Cytochrome P450” in Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition Ed. Paul Otiz de Montellano, Springer, 2015. 07/16/2015

Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition. (Olson LJ, Orsi R, Peterson FC, Parodi AJ, Kim JJ, D'Alessio C, Dahms NM) Biochemistry 2015 Jul 07;54(26):4097-111 PMID: 26062005 PMCID: PMC6202027 SCOPUS ID: 2-s2.0-84936769044 06/11/2015 14 Citations

Bacterial expression of the phosphodiester-binding site of the cation-independent mannose 6-phosphate receptor for crystallographic and NMR studies. (Olson LJ, Jensen DR, Volkman BF, Kim JJ, Peterson FC, Gundry RL, Dahms NM) Protein Expr Purif 2015 Jul;111:91-7 PMID: 25863146 PMCID: PMC4417374 SCOPUS ID: 2-s2.0-84927727743 04/12/2015 1 Citation

Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry. (Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT) J Biol Chem 2012 Nov 23;287(48):40806-16 PMID: 23027864 PMCID: PMC3504792 SCOPUS ID: 2-s2.0-84870028543 10/03/2012 43 Citations

NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family. (Iyanagi T, Xia C, Kim JJ) Arch Biochem Biophys 2012 Dec 01;528(1):72-89 PMID: 22982532 PMCID: PMC3606592 SCOPUS ID: 2-s2.0-84867121243 09/18/2012 107 Citations

Unique ganglioside recognition strategies for clostridial neurotoxins. (Benson MA, Fu Z, Kim JJ, Baldwin MR) J Biol Chem 2011 Sep 30;286(39):34015-22 PMID: 21849494 PMCID: PMC3190786 SCOPUS ID: 2-s2.0-80053201230 08/19/2011 52 Citations

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. (Xia C, Panda SP, Marohnic CC, Martásek P, Masters BS, Kim JJ) Proc Natl Acad Sci U S A 2011 Aug 16;108(33):13486-91 PMID: 21808038 PMCID: PMC3158178 SCOPUS ID: 2-s2.0-80051958464 08/03/2011 106 Citations

Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons. (Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT) J Biol Chem 2011 Jul 29;286(30):26828-37 PMID: 21632541 PMCID: PMC3143643 SCOPUS ID: 2-s2.0-79960680902 06/03/2011 35 Citations

Unique ganglioside binding by botulinum neurotoxins C and D-SA. (Kroken AR, Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT) FEBS J 2011 Dec;278(23):4486-96 PMID: 21554541 PMCID: PMC3170675 SCOPUS ID: 2-s2.0-81555216752 05/11/2011 23 Citations

Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding. (Xia C, Hamdane D, Shen AL, Choi V, Kasper CB, Pearl NM, Zhang H, Im SC, Waskell L, Kim JJ) J Biol Chem 2011 May 06;286(18):16246-60 PMID: 21345800 PMCID: PMC3091232 SCOPUS ID: 2-s2.0-79955543878 02/25/2011 96 Citations

Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA . (Karalewitz AP, Kroken AR, Fu Z, Baldwin MR, Kim JJ, Barbieri JT) Biochemistry 2010 Sep 21;49(37):8117-26 PMID: 20731382 PMCID: PMC2939319 SCOPUS ID: 2-s2.0-77956591091 08/25/2010 51 Citations

Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. (Fu Z, Runquist JA, Montgomery C, Miziorko HM, Kim JJ) J Biol Chem 2010 Aug 20;285(34):26341-9 PMID: 20558737 PMCID: PMC2924059 SCOPUS ID: 2-s2.0-77956213412 06/19/2010 21 Citations

Compared effects of missense mutations in Very-Long-Chain Acyl-CoA Dehydrogenase deficiency: Combined analysis by structural, functional and pharmacological approaches. (Gobin-Limballe S, McAndrew RP, Djouadi F, Kim JJ, Bastin J) Biochim Biophys Acta 2010 May;1802(5):478-84 PMID: 20060901 PMCID: PMC3401415 SCOPUS ID: 2-s2.0-77950367893 01/12/2010 35 Citations

Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. (Olson LJ, Sun G, Bohnsack RN, Peterson FC, Dahms NM, Kim JJ) Biochemistry 2010 Jan 12;49(1):236-46 PMID: 19928875 PMCID: PMC2802658 SCOPUS ID: 2-s2.0-73449127633 11/26/2009 8 Citations

Carbohydrate recognition by the mannose-6-phosphate receptors. (Kim JJ, Olson LJ, Dahms NM) Curr Opin Struct Biol 2009 Oct;19(5):534-42 PMID: 19801188 PMCID: PMC2771201 SCOPUS ID: 2-s2.0-70349882101 10/06/2009 69 Citations

Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase. (Xia C, Misra I, Iyanagi T, Kim JJ) J Biol Chem 2009 Oct 30;284(44):30708-17 PMID: 19737939 PMCID: PMC2781624 SCOPUS ID: 2-s2.0-71049135329 09/10/2009 91 Citations

Gangliosides as high affinity receptors for tetanus neurotoxin. (Chen C, Fu Z, Kim JJ, Barbieri JT, Baldwin MR) J Biol Chem 2009 Sep 25;284(39):26569-77 PMID: 19602728 PMCID: PMC2785345 SCOPUS ID: 2-s2.0-70350371732 07/16/2009 111 Citations

Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F. (Fu Z, Chen C, Barbieri JT, Kim JJ, Baldwin MR) Biochemistry 2009 Jun 23;48(24):5631-41 PMID: 19476346 PMCID: PMC2709598 SCOPUS ID: 2-s2.0-67649210455 05/30/2009 133 Citations

Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. (Hamdane D, Xia C, Im SC, Zhang H, Kim JJ, Waskell L) J Biol Chem 2009 Apr 24;284(17):11374-84 PMID: 19171935 PMCID: PMC2670143 SCOPUS ID: 2-s2.0-66449111327 01/28/2009 193 Citations

Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. (Voynova NE, Fu Z, Battaile KP, Herdendorf TJ, Kim JJ, Miziorko HM) Arch Biochem Biophys 2008 Dec 01;480(1):58-67 PMID: 18823933 PMCID: PMC2709241 SCOPUS ID: 2-s2.0-55649114634 10/01/2008 40 Citations

Strategies for carbohydrate recognition by the mannose 6-phosphate receptors. (Dahms NM, Olson LJ, Kim JJ) Glycobiology 2008 Sep;18(9):664-78 PMID: 18621992 PMCID: PMC2733771 SCOPUS ID: 2-s2.0-58149107948 07/16/2008 91 Citations

NADPH-cytochrome P450 oxidoreductase from the mosquito Anopheles minimus: kinetic studies and the influence of Leu86 and Leu219 on cofactor binding and protein stability. (Sarapusit S, Xia C, Misra I, Rongnoparut P, Kim JJ) Arch Biochem Biophys 2008 Sep 01;477(1):53-9 PMID: 18539133 PMCID: PMC2548334 SCOPUS ID: 2-s2.0-48949102647 06/10/2008 15 Citations

Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. (Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ) Biochemistry 2008 Mar 25;47(12):3715-24 PMID: 18302342 SCOPUS ID: 2-s2.0-41149152855 02/28/2008 35 Citations

Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor. (Olson LJ, Hindsgaul O, Dahms NM, Kim JJ) J Biol Chem 2008 Apr 11;283(15):10124-34 PMID: 18272523 PMCID: PMC2442308 SCOPUS ID: 2-s2.0-44349171796 02/15/2008 35 Citations

Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase. (McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ) J Biol Chem 2008 Apr 04;283(14):9435-43 PMID: 18227065 PMCID: PMC2431035 SCOPUS ID: 2-s2.0-44049088356 01/30/2008 92 Citations

Two distinct proton donors at the active site of Escherichia coli 2,4-dienoyl-CoA reductase are responsible for the formation of different products. (Tu X, Hubbard PA, Kim JJ, Schulz H) Biochemistry 2008 Jan 29;47(4):1167-75 PMID: 18171025 SCOPUS ID: 2-s2.0-38549138982 01/04/2008 14 Citations

The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate. (Rao KS, Fu Z, Albro M, Narayanan B, Baddam S, Lee HJ, Kim JJ, Frerman FE) Biochemistry 2007 Dec 18;46(50):14468-77 PMID: 18020372 SCOPUS ID: 2-s2.0-37249001773 11/21/2007 10 Citations

Mechanism of substrate recognition by botulinum neurotoxin serotype A. (Chen S, Kim JP, Barbieri JT) J Biol Chem 2007 Mar 30;282(13):9621-9627 PMID: 17244603 SCOPUS ID: 2-s2.0-34248213125 01/25/2007 83 Citations

Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. (Baldwin MR, Kim JJ, Barbieri JT) Nat Struct Mol Biol 2007 Jan;14(1):9-10 PMID: 17203068 SCOPUS ID: 2-s2.0-33846065566 01/05/2007 25 Citations

Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool. (Zhang J, Frerman FE, Kim JJ) Proc Natl Acad Sci U S A 2006 Oct 31;103(44):16212-7 PMID: 17050691 PMCID: PMC1637562 SCOPUS ID: 2-s2.0-33750814320 10/20/2006 180 Citations

Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. (Fu Z, Chen S, Baldwin MR, Boldt GE, Crawford A, Janda KD, Barbieri JT, Kim JJ) Biochemistry 2006 Jul 25;45(29):8903-11 PMID: 16846233 SCOPUS ID: 2-s2.0-33746268620 07/19/2006 52 Citations

Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria. (Fu Z, Runquist JA, Forouhar F, Hussain M, Hunt JF, Miziorko HM, Kim JJ) J Biol Chem 2006 Mar 17;281(11):7526-32 PMID: 16330550 SCOPUS ID: 2-s2.0-33646343977 12/07/2005 26 Citations

Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. (Forouhar F, Hussain M, Farid R, Benach J, Abashidze M, Edstrom WC, Vorobiev SM, Xiao R, Acton TB, Fu Z, Kim JJ, Miziorko HM, Montelione GT, Hunt JF) J Biol Chem 2006 Mar 17;281(11):7533-45 PMID: 16330546 SCOPUS ID: 2-s2.0-33646342512 12/07/2005 28 Citations

Crystal structure of the interferon-induced ubiquitin-like protein ISG15. (Narasimhan J, Wang M, Fu Z, Klein JM, Haas AL, Kim JJ) J Biol Chem 2005 Jul 22;280(29):27356-65 PMID: 15917233 SCOPUS ID: 2-s2.0-22844450969 05/27/2005 190 Citations

Domain swapping in the low-similarity isomerase/hydratase superfamily: the crystal structure of rat mitochondrial Delta3, Delta2-enoyl-CoA isomerase. (Hubbard PA, Yu W, Schulz H, Kim JJ) Protein Sci 2005 Jun;14(6):1545-55 PMID: 15883186 PMCID: PMC2253373 SCOPUS ID: 2-s2.0-22444431672 05/11/2005 21 Citations

How bacterial ADP-ribosylating toxins recognize substrates. (Sun J, Maresso AW, Kim JJ, Barbieri JT) Nat Struct Mol Biol 2004 Sep;11(9):868-76 PMID: 15311272 SCOPUS ID: 2-s2.0-4344717785 08/18/2004 65 Citations

Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions. (Fu Z, Wang M, Paschke R, Rao KS, Frerman FE, Kim JJ) Biochemistry 2004 Aug 03;43(30):9674-84 PMID: 15274622 SCOPUS ID: 2-s2.0-3342953763 07/28/2004 80 Citations

The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. (Olson LJ, Dahms NM, Kim JJ) J Biol Chem 2004 Aug 06;279(32):34000-9 PMID: 15169779 SCOPUS ID: 2-s2.0-4043147868 06/01/2004 54 Citations

Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor. (Olson LJ, Yammani RD, Dahms NM, Kim JJ) EMBO J 2004 May 19;23(10):2019-28 PMID: 15085180 PMCID: PMC424385 SCOPUS ID: 2-s2.0-2942558373 04/16/2004 55 Citations

Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases. (Battaile KP, Nguyen TV, Vockley J, Kim JJ) J Biol Chem 2004 Apr 16;279(16):16526-34 PMID: 14752098 SCOPUS ID: 2-s2.0-1942533442 01/31/2004 62 Citations

Acyl-CoA dehydrogenases and acyl-CoA oxidases. Structural basis for mechanistic similarities and differences. (Kim JJ, Miura R) Eur J Biochem 2004 Feb;271(3):483-93 PMID: 14728675 SCOPUS ID: 2-s2.0-0842265784 01/20/2004 169 Citations

The crystal structure and reaction mechanism of Escherichia coli 2,4-dienoyl-CoA reductase. (Hubbard PA, Liang X, Schulz H, Kim JJ) J Biol Chem 2003 Sep 26;278(39):37553-60 PMID: 12840019 SCOPUS ID: 2-s2.0-0141621166 07/04/2003 54 Citations

Burning fat: the structural basis of fatty acid beta-oxidation. (Kim JJ, Battaile KP) Curr Opin Struct Biol 2002 Dec;12(6):721-8 PMID: 12504675 SCOPUS ID: 2-s2.0-0036913740 12/31/2002 66 Citations

The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. (Fu Z, Wang M, Potter D, Miziorko HM, Kim JJ) J Biol Chem 2002 May 17;277(20):18134-42 PMID: 11877411 SCOPUS ID: 2-s2.0-0037124052 03/06/2002 110 Citations

Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases. (Battaile KP, Molin-Case J, Paschke R, Wang M, Bennett D, Vockley J, Kim JJ) J Biol Chem 2002 Apr 05;277(14):12200-7 PMID: 11812788 SCOPUS ID: 2-s2.0-0037023717 01/29/2002 75 Citations

Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor. (Olson LJ, Zhang J, Dahms NM, Kim JJ) J Biol Chem 2002 Mar 22;277(12):10156-61 PMID: 11786557 SCOPUS ID: 2-s2.0-0037155883 01/12/2002 43 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Jung Ja P. Kim PhD

Professor

Publications (59)