Karthikeyan Thirugnanam
Research Scientist I
Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Pediatrics Neonatology
I am willing to collaborate on research projects.
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Research Areas of Interest
Developmental BiologyCilia BiologyVascular Development and DiseasesResearch Experience
BiochemistryCardiovascular DiseasesCerebral HemorrhageCerebral Small Vessel DiseasesDevelopmental BiologyIntracranial HemorrhagesPublications (17)
PDGF-BB as a potential biomarker for early diagnosis of postpartum hemorrhage. (Thirugnanam K, Polnaszek BE, Eng K, Pan AY, Ramchandran R) Front Glob Womens Health 2026;7:1849806 PMID: 42389024 PMCID: PMC13318863 SCOPUS ID: 2-s2.0-105044394315 07/02/2026 Ciliary p75 neurotrophin receptor (p75NTR) facilitates the enrichment of exogenous amyloid beta (Aβ 1-42) peptide and promotes oxidative stress in human hippocampal astrocytes. (Gupta A, Thirugnanam K, Bice Z, Lowman AK, Rarick KR, LaViolette PS, Pan A, Franczak M, Ramchandran R) BMC Mol Cell Biol 2026 Mar 18;27(1) PMID: 41851829 PMCID: PMC13122876 SCOPUS ID: 2-s2.0-105037047856 03/19/2026 Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side of endothelium. (Prabhudesai S, Thirugnanam K, Song X, Yang H, Errede M, Girolamo F, Neumann T, Marzullo A, Bafti S, Vanderhoef K, Rarick KR, Spearman AD, Pan AY, Alvarez CA, Yang J, Zhang F, Dordick JS, Virgintino D, Wang L, Ramchandran R) Life Sci Alliance 2026 Mar;9(3) PMID: 41490797 PMCID: PMC12769094 SCOPUS ID: 2-s2.0-105026638885 01/06/2026 3 CitationsSNRK facilitates cardiac repair associated with nonischemic fibrosis: regulating transforming growth factor-beta1 levels in atrial cardiomyocytes. (Thirugnanam K, Rizvi F, Jahangir A, Homar P, Shabnam F, Palecek SP, Kumar SN, Pan A, Bai X, Sekine H, Ramchandran R) Regen Med Rep 2025 Jun;2(2):45-52 PMID: 40584789 PMCID: PMC12204380 07/01/2025 Comparative Proteomic Analysis Reveals Altered Ciliary Proteins in Sickle Cell Disease. (Mohieldin AM, Spencer M, Bernal C, Fadol WB, Gupta A, Thirugnanam K, Delahunty C, Nunez F, Pan AY, Brandow AM, Palecek SP, Rarick KR, Ramchandran R, Zennadi R, Yates J 3rd, Nauli SM) J Proteome Res 2025 Jun 06;24(6):2981-2995 PMID: 40374167 PMCID: PMC12151070 SCOPUS ID: 2-s2.0-105005461889 05/16/2025 SNRK regulates TGFβ levels in atria to control cardiac fibrosis. (Thirugnanam K, Rizvi F, Jahangir A, Homar P, Shabnam F, Palecek SP, Kumar SN, Pan A, Bai X, Sekine H, Ramchandran R) bioRxiv 2024 Sep 26 PMID: 39386731 PMCID: PMC11463613 10/10/2024 Brain microvascular endothelial cells possess a second cilium that arises from the daughter centriole. (Thirugnanam K, Gupta A, Nunez F, Prabhudesai S, Pan AY, Nauli SM, Ramchandran R) Front Mol Biosci 2023;10:1250016 PMID: 38028541 PMCID: PMC10657992 SCOPUS ID: 2-s2.0-85177189351 11/29/2023 3 CitationsCiliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. (Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP, Ramchandran R) Biochem Pharmacol 2022 Aug;202:115143 PMID: 35700757 PMCID: PMC11274820 SCOPUS ID: 2-s2.0-85132215893 06/15/2022 10 CitationsCilia proteins are biomarkers of altered flow in the vasculature. (Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R) JCI Insight 2022 Mar 22;7(6) PMID: 35143420 PMCID: PMC8986075 SCOPUS ID: 2-s2.0-85127051401 02/11/2022 11 CitationsSNRK: a metabolic regulator with multifaceted role in development and disease. (Thirugnanam K, Ramchandran R) Vessel Plus 2020;4 PMID: 32968716 PMCID: PMC7508454 09/25/2020 Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. (Dey A, Prabhudesai S, Zhang Y, Rao G, Thirugnanam K, Hossen MN, Dwivedi SKD, Ramchandran R, Mukherjee P, Bhattacharya R) Sci Adv 2020 Jul;6(27) PMID: 32937467 PMCID: PMC7458453 SCOPUS ID: 2-s2.0-85088472971 09/17/2020 56 CitationsHepatic Vein Blood Increases Lung Microvascular Angiogenesis and Endothelial Cell Survival-Toward an Understanding of Univentricular Circulation. (Spearman AD, Gupta A, Pan AY, Gronseth EI, Thirugnanam K, Gudausky TM, Foerster SR, Ramchandran R) Semin Thorac Cardiovasc Surg 2020 Winter;32(4):980-987 PMID: 32387780 PMCID: PMC7647938 SCOPUS ID: 2-s2.0-85086171858 05/11/2020 13 CitationsNeuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels. (Vasquez-Vivar J, Shi Z, Jeong JW, Luo K, Sharma A, Thirugnanam K, Tan S) Redox Biol 2020 Jan;29:101407 PMID: 31926630 PMCID: PMC6928344 SCOPUS ID: 2-s2.0-85076556552 01/14/2020 37 CitationsCardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. (Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, Spearman AD, Sonin DL, Bordas M, Kumar SN, Pan AY, Simpson PM, Strande JL, Bishop E, Zou MH, Ramchandran R) J Am Heart Assoc 2019 Nov 19;8(22):e012792 PMID: 31718444 PMCID: PMC6915262 SCOPUS ID: 2-s2.0-85075040816 11/14/2019 14 CitationsTetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy. (Vasquez-Vivar J, Shi Z, Luo K, Thirugnanam K, Tan S) Redox Biol 2017 Oct;13:594-599 PMID: 28803128 PMCID: PMC5554922 SCOPUS ID: 2-s2.0-85027861384 08/15/2017 37 CitationsMolecular basis of the anti-inflammatory potential of a diarylheptanoid in murine macrophage RAW 264.7 cells (Bharathi Raja Rajaganapathy, Karthikeyan Thirugnanam, Muthusamy Velusamy Shanmuganathan, Anand Singaravelu, Lakshmi Baddireddi Subadhra) Advances in Biological Chemistry 11/22/2013 In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei (Thirugnanam Karthikeyan, Mariappan Pravin, Velusamy Shanmuganathan Muthusamy, Rajaganapathy Bharathi Raja, Baddireddi Subhadra Lakshmi) Probiotics and Antimicrobial Proteins 03/15/2013
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