Faculty Collaboration Database

Kazuhiro Aoki PhD, MEd

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology Neurobiology and Anatomy

image of /images/ORCIDiD_icon16x16.png https://orcid.org/0000-0003-0029-4291

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Publications (79)

Metabolic Response to CDK4/6 Inhibition in ER+ Breast Cancer Creates a Therapeutic Vulnerability in Drug-Tolerant Persister Cells. (Yang H, Tau S, McCray AD, Roberts AM, Marotti JD, Muller K, Huang Y, Al Mamun M, Aoki K, Demidenko E, Miller TW) FASEB J 2026 Apr 15;40(7):e71746 PMID: 41920074 SCOPUS ID: 2-s2.0-105034818382 04/01/2026

Differential O-glucose elongation on a specific EGF repeat within the canonical ligand-binding domain regulates DLL1/4-NOTCH1 signaling. (Tsukamoto Y, Aoki K, Kama Y, Hosokawa H, Saiki W, Tsukamoto N, Kato K, Hosokawa Y, Sato R, Uesugi N, Fujita Y, Fukazawa K, Funada D, Suzuki F, Kurebayashi Y, Urata Y, Uchiyama S, Wang W, Minami A, Takahashi T, Tiemeyer M, Narimatsu Y, Okajima T, Takeuchi H) Proc Natl Acad Sci U S A 2025 Oct 28;122(43):e2504827122 PMID: 41129232 PMCID: PMC12582257 SCOPUS ID: 2-s2.0-105019822657 10/23/2025 1 Citation

DANGO: An MS data annotation tool for glycolipidomics (Matsubara M, Ishihara M, Tiemeyer M, Aoki K, Ranzinger R) Bba Advances January 2025;7 SCOPUS ID: 2-s2.0-105005183421 01/01/2025 2 Citations

MicroGlycoDB: A database of microbial glycans using Semantic Web technologies. (Lee S, Leclercq LD, Guerardel Y, Szymanski CM, Hurtaux T, Doering TL, Katayama T, Fujita K, Aoki K, Aoki-Kinoshita KF) BBA Adv 2024;6:100126 PMID: 39720162 PMCID: PMC11667048 SCOPUS ID: 2-s2.0-85211163528 12/25/2024 3 Citations

Glycosphingolipids and their impact on platelet activity in a murine model of fabry disease. (Kanack AJ, Prodoehl E, Ishihara-Aoki M, Aoki K, Dahms NM) Sci Rep 2024 Nov 27;14(1):29488 PMID: 39604471 PMCID: PMC11603304 SCOPUS ID: 2-s2.0-85210527022 11/28/2024 2 Citations

Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2. (Bohnsack RN, Misra SK, Liu J, Ishihara-Aoki M, Pereckas M, Aoki K, Ren G, Sharp JS, Dahms NM) Sci Rep 2024 Nov 06;14(1):26875 PMID: 39505925 PMCID: PMC11541866 SCOPUS ID: 2-s2.0-85208688601 11/07/2024 7 Citations

Studying the O-GlcNAcome of human placentas using banked tissue samples. (Luna S, Malard F, Pereckas M, Aoki M, Aoki K, Olivier-Van Stichelen S) Glycobiology 2024 Apr 10;34(4) PMID: 38253038 PMCID: PMC11005170 SCOPUS ID: 2-s2.0-85190109720 01/23/2024 8 Citations

Neural-specific alterations in glycosphingolipid biosynthesis and cell signaling associated with two human ganglioside GM3 synthase deficiency variants. (Dookwah M, Wagner SK, Ishihara M, Yu SH, Ulrichs H, Kulik MJ, Zeltner N, Dalton S, Strauss KA, Aoki K, Steet R, Tiemeyer M) Hum Mol Genet 2023 Dec 01;32(24):3323-3341 PMID: 37676252 PMCID: PMC10695682 SCOPUS ID: 2-s2.0-85178658258 09/07/2023 11 Citations

Mucin glycans drive oral microbial community composition and function. (Wu CM, Wheeler KM, Cárcamo-Oyarce G, Aoki K, McShane A, Datta SS, Mark Welch JL, Tiemeyer M, Griffen AL, Ribbeck K) NPJ Biofilms Microbiomes 2023 Mar 23;9(1):11 PMID: 36959210 PMCID: PMC10036478 SCOPUS ID: 2-s2.0-85150885000 03/25/2023 30 Citations

Characterization of the human platelet N- and O-glycome upon storage using tandem mass spectrometry. (Rosenbalm KE, Lee-Sundlov MM, Ashline DJ, Grozovsky R, Aoki K, Hanneman AJS, Hoffmeister KM) Blood Adv 2023 Aug 22;7(16):4278-4290 PMID: 36952551 PMCID: PMC10424148 SCOPUS ID: 2-s2.0-85161978571 03/24/2023 17 Citations

Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. (Scott H, Novikov B, Ugur B, Allen B, Mertsalov I, Monagas-Valentin P, Koff M, Baas Robinson S, Aoki K, Veizaj R, Lefeber DJ, Tiemeyer M, Bellen H, Panin V) Elife 2023 Mar 22;12 PMID: 36946697 PMCID: PMC10110239 SCOPUS ID: 2-s2.0-85151561936 03/23/2023 6 Citations

Compound heterozygous variants within two conserved sialyltransferase motifs of ST3GAL5 cause GM3 synthase deficiency. (Rudy N, Aoki K, Ananth A, Holloway L, Skinner C, Hurst A, Tiemeyer M, Steet R) JIMD Rep 2023 Mar;64(2):138-145 PMID: 36873089 PMCID: PMC9981410 SCOPUS ID: 2-s2.0-85149928831 03/07/2023 5 Citations

Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation. (Hollenhorst MA, Tiemeyer KH, Mahoney KE, Aoki K, Ishihara M, Lowery SC, Rangel-Angarita V, Bertozzi CR, Malaker SA) J Thromb Haemost 2023 Apr;21(4):995-1009 PMID: 36740532 PMCID: PMC10065957 SCOPUS ID: 2-s2.0-85150252223 02/06/2023 25 Citations

Host-derived O-glycans inhibit toxigenic conversion by a virulence-encoding phage in Vibrio cholerae (Wang BX, Takagi J, McShane A, Park JH, Aoki K, Griffin C, Teschler J, Kitts G, Minzer G, Tiemeyer M, Hevey R, Yildiz F, Ribbeck K) EMBO Journal 1 February 2023;42(3) SCOPUS ID: 2-s2.0-85143780784 02/01/2023 25 Citations

Host-derived O-glycans inhibit toxigenic conversion by a virulence-encoding phage in Vibrio cholerae. (Wang BX, Takagi J, McShane A, Park JH, Aoki K, Griffin C, Teschler J, Kitts G, Minzer G, Tiemeyer M, Hevey R, Yildiz F, Ribbeck K) EMBO J 2023 Feb 01;42(3):e111562 PMID: 36504455 PMCID: PMC9890226 SCOPUS ID: 2-s2.0-85143780784 12/13/2022 25 Citations

Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity. (Takagi J, Aoki K, Turner BS, Lamont S, Lehoux S, Kavanaugh N, Gulati M, Valle Arevalo A, Lawrence TJ, Kim CY, Bakshi B, Ishihara M, Nobile CJ, Cummings RD, Wozniak DJ, Tiemeyer M, Hevey R, Ribbeck K) Nat Chem Biol 2022 Jul;18(7):762-773 PMID: 35668191 PMCID: PMC7613833 SCOPUS ID: 2-s2.0-85131603189 06/07/2022 80 Citations

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. (Gonzalez-Gil A, Porell RN, Fernandes SM, Maenpaa E, Li TA, Li T, Wong PC, Aoki K, Tiemeyer M, Yu ZJ, Orsburn BC, Bumpus NN, Matthews RT, Schnaar RL) J Biol Chem 2022 Jun;298(6):101960 PMID: 35452678 PMCID: PMC9130525 SCOPUS ID: 2-s2.0-85130705298 04/23/2022 42 Citations

Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis. (Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, Goodell HP, Thacker H, Loznev HT, Forsberg LJ, Nagase T, Rubinstein M, Randell SH, Tiemeyer M, Hill DB, Kesimer M, O'Neal WK, Ballard ST, Freeman R, Button B, Boucher RC) Sci Adv 2022 Apr;8(13):eabm9718 PMID: 35363522 PMCID: PMC10938572 SCOPUS ID: 2-s2.0-85127523093 04/02/2022 17 Citations

Serum N-Glycome Diversity in Teleost and Chondrostrean Fishes. (Aoki K, Kumagai T, Ranzinger R, Bergmann C, Camus A, Tiemeyer M) Front Mol Biosci 2021;8:778383 PMID: 34859056 PMCID: PMC8631502 SCOPUS ID: 2-s2.0-85120429459 12/04/2021 3 Citations

Platelet and myeloid cell phenotypes in a rat model of Fabry disease. (Kanack AJ, Aoki K, Tiemeyer M, Dahms NM) FASEB J 2021 Aug;35(8):e21818 PMID: 34320241 PMCID: PMC8341388 SCOPUS ID: 2-s2.0-85111530832 07/29/2021 4 Citations

Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate. (Miller JJ, Bohnsack RN, Olson LJ, Ishihara M, Aoki K, Tiemeyer M, Dahms NM) Sci Rep 2021 Apr 15;11(1):8213 PMID: 33859256 PMCID: PMC8050316 SCOPUS ID: 2-s2.0-85104287178 04/17/2021 4 Citations

Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans. (Werlang CA, Chen WG, Aoki K, Wheeler KM, Tymm C, Mileti CJ, Burgos AC, Kim K, Tiemeyer M, Ribbeck K) Nat Microbiol 2021 May;6(5):574-583 PMID: 33737747 PMCID: PMC8811953 SCOPUS ID: 2-s2.0-85103067573 03/20/2021 62 Citations

Global mapping of glycosylation pathways in human-derived cells. (Huang YF, Aoki K, Akase S, Ishihara M, Liu YS, Yang G, Kizuka Y, Mizumoto S, Tiemeyer M, Gao XD, Aoki-Kinoshita KF, Fujita M) Dev Cell 2021 Apr 19;56(8):1195-1209.e7 PMID: 33730547 PMCID: PMC8086148 SCOPUS ID: 2-s2.0-85104060411 03/18/2021 88 Citations

Glycomics-informed glycoproteomic analysis of site-specific glycosylation for SARS-CoV-2 spike protein. (Rosenbalm KE, Tiemeyer M, Wells L, Aoki K, Zhao P) STAR Protoc 2020 Dec 18;1(3):100214 PMID: 33377107 PMCID: PMC7757665 SCOPUS ID: 2-s2.0-85104071101 12/31/2020 14 Citations

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor. (Zhao P, Praissman JL, Grant OC, Cai Y, Xiao T, Rosenbalm KE, Aoki K, Kellman BP, Bridger R, Barouch DH, Brindley MA, Lewis NE, Tiemeyer M, Chen B, Woods RJ, Wells L) Cell Host Microbe 2020 Oct 07;28(4):586-601.e6 PMID: 32841605 PMCID: PMC7443692 SCOPUS ID: 2-s2.0-85090566044 08/26/2020 353 Citations

Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8. (Gonzalez-Gil A, Li TA, Porell RN, Fernandes SM, Tarbox HE, Lee HS, Aoki K, Tiemeyer M, Kim J, Schnaar RL) J Allergy Clin Immunol 2021 Apr;147(4):1442-1452 PMID: 32791164 PMCID: PMC7876160 SCOPUS ID: 2-s2.0-85090223610 08/14/2020 29 Citations

Profiling of O-acetylated Gangliosides Expressed in Neuroectoderm Derived Cells. (Cavdarli S, Yamakawa N, Clarisse C, Aoki K, Brysbaert G, Le Doussal JM, Delannoy P, Guérardel Y, Groux-Degroote S) Int J Mol Sci 2020 Jan 06;21(1) PMID: 31935967 PMCID: PMC6981417 SCOPUS ID: 2-s2.0-85077853871 01/16/2020 27 Citations

Sulfated Lewis A trisaccharide on oviduct membrane glycoproteins binds bovine sperm and lengthens sperm lifespan. (Dutta S, Aoki K, Doungkamchan K, Tiemeyer M, Bovin N, Miller DJ) J Biol Chem 2019 Sep 06;294(36):13445-13463 PMID: 31337705 PMCID: PMC6737213 SCOPUS ID: 2-s2.0-85071832006 07/25/2019 24 Citations

Rats deficient in α-galactosidase A develop ocular manifestations of Fabry disease. (Miller JJ, Aoki K, Reid CA, Tiemeyer M, Dahms NM, Kassem IS) Sci Rep 2019 Jun 28;9(1):9392 PMID: 31253878 PMCID: PMC6599056 SCOPUS ID: 2-s2.0-85068107461 06/30/2019 9 Citations

Recessive GM3 synthase deficiency: Natural history, biochemistry, and therapeutic frontier. (Bowser LE, Young M, Wenger OK, Ammous Z, Brigatti KW, Carson VJ, Moser T, Deline J, Aoki K, Morlet T, Scott EM, Puffenberger EG, Robinson DL, Hendrickson C, Salvin J, Gottlieb S, Heaps AD, Tiemeyer M, Strauss KA) Mol Genet Metab 2019 Apr;126(4):475-488 PMID: 30691927 SCOPUS ID: 2-s2.0-85060445951 01/30/2019 48 Citations

A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation. (Ferreira CR, Xia ZJ, Clément A, Parry DA, Davids M, Taylan F, Sharma P, Turgeon CT, Blanco-Sánchez B, Ng BG, Logan CV, Wolfe LA, Solomon BD, Cho MT, Douglas G, Carvalho DR, Bratke H, Haug MG, Phillips JB, Wegner J, Tiemeyer M, Aoki K, Undiagnosed Diseases Network, Scottish Genome Partnership, Nordgren A, Hammarsjö A, Duker AL, Rohena L, Hove HB, Ek J, Adams D, Tifft CJ, Onyekweli T, Weixel T, Macnamara E, Radtke K, Powis Z, Earl D, Gabriel M, Russi AHS, Brick L, Kozenko M, Tham E, Raymond KM, Phillips JA 3rd, Tiller GE, Wilson WG, Hamid R, Malicdan MCV, Nishimura G, Grigelioniene G, Jackson A, Westerfield M, Bober MB, Gahl WA, Freeze HH) Am J Hum Genet 2018 Oct 04;103(4):553-567 PMID: 30290151 PMCID: PMC6174323 SCOPUS ID: 2-s2.0-85054014584 10/06/2018 62 Citations

α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease. (Miller JJ, Aoki K, Mascari CA, Beltrame AK, Sokumbi O, North PE, Tiemeyer M, Kriegel AJ, Dahms NM) FASEB J 2019 Jan;33(1):418-429 PMID: 29979634 PMCID: PMC6629127 SCOPUS ID: 2-s2.0-85059237456 07/07/2018 26 Citations

Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways. (Gonzalez-Gil A, Porell RN, Fernandes SM, Wei Y, Yu H, Carroll DJ, McBride R, Paulson JC, Tiemeyer M, Aoki K, Bochner BS, Schnaar RL) Glycobiology 2018 Oct 01;28(10):786-801 PMID: 29924315 PMCID: PMC6142871 SCOPUS ID: 2-s2.0-85055616432 06/21/2018 56 Citations

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency. (Kumagai T, Kiwamoto T, Brummet ME, Wu F, Aoki K, Zhu Z, Bochner BS, Tiemeyer M) Glycobiology 2018 Jun 01;28(6):406-417 PMID: 29659839 PMCID: PMC5967469 SCOPUS ID: 2-s2.0-85048231573 04/17/2018 16 Citations

Neuropathic pain in a Fabry disease rat model. (Miller JJ, Aoki K, Moehring F, Murphy CA, O'Hara CL, Tiemeyer M, Stucky CL, Dahms NM) JCI Insight 2018 Mar 22;3(6) PMID: 29563343 PMCID: PMC5926911 SCOPUS ID: 2-s2.0-85058370681 03/23/2018 60 Citations

Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles. (Itoh K, Akimoto Y, Kondo S, Ichimiya T, Aoki K, Tiemeyer M, Nishihara S) Dev Biol 2018 Apr 15;436(2):108-124 PMID: 29499182 PMCID: PMC5898651 SCOPUS ID: 2-s2.0-85042880794 03/03/2018 17 Citations

Applying glycomic technology to investigate the consequences of altered glycosylation in human ST3GAL5 deficiency (Aoki K, Tiemeyer M) Trends in Glycoscience and Glycotechnology 2018;30(173):E33-E40 SCOPUS ID: 2-s2.0-85044355101 01/01/2018

GlyTouCan: an accessible glycan structure repository. (Tiemeyer M, Aoki K, Paulson J, Cummings RD, York WS, Karlsson NG, Lisacek F, Packer NH, Campbell MP, Aoki NP, Fujita A, Matsubara M, Shinmachi D, Tsuchiya S, Yamada I, Pierce M, Ranzinger R, Narimatsu H, Aoki-Kinoshita KF) Glycobiology 2017 Oct 01;27(10):915-919 PMID: 28922742 PMCID: PMC5881658 SCOPUS ID: 2-s2.0-85031113886 09/20/2017 144 Citations

Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance. (Lopez PH, Aja S, Aoki K, Seldin MM, Lei X, Ronnett GV, Wong GW, Schnaar RL) Glycobiology 2017 Jan;27(2):129-139 PMID: 27683310 PMCID: PMC5224593 SCOPUS ID: 2-s2.0-85014502638 09/30/2016 26 Citations

Mass Spectrometric Quantification of N-Linked Glycans by Reference to Exogenous Standards. (Mehta N, Porterfield M, Struwe WB, Heiss C, Azadi P, Rudd PM, Tiemeyer M, Aoki K) J Proteome Res 2016 Sep 02;15(9):2969-80 PMID: 27432553 PMCID: PMC5501980 SCOPUS ID: 2-s2.0-84985993219 07/20/2016 37 Citations

Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. (Parkinson WM, Dookwah M, Dear ML, Gatto CL, Aoki K, Tiemeyer M, Broadie K) Dis Model Mech 2016 May 01;9(5):513-27 PMID: 26940433 PMCID: PMC4892659 SCOPUS ID: 2-s2.0-84966460670 03/05/2016 32 Citations

Targeted release and fractionation reveal glucuronylated and sulphated N- and O-glycans in larvae of dipteran insects. (Kurz S, Aoki K, Jin C, Karlsson NG, Tiemeyer M, Wilson IB, Paschinger K) J Proteomics 2015 Aug 03;126:172-88 PMID: 26047717 PMCID: PMC4523410 SCOPUS ID: 2-s2.0-84930936821 06/07/2015 68 Citations

Analysis of sulfoglycolipids by mass spectrometry (Tiemeyer M, Aoki K) Glycoscience Biology and Medicine 1 January 2015:135-161 SCOPUS ID: 2-s2.0-84943638951 01/01/2015

Improved in-gel reductive β-elimination for comprehensive O-linked and sulfo-glycomics by mass spectrometry. (Nix DB, Kumagai T, Katoh T, Tiemeyer M, Aoki K) J Vis Exp 2014 Nov 20(93):e51840 PMID: 25489664 PMCID: PMC4354198 SCOPUS ID: 2-s2.0-84911937252 12/10/2014 9 Citations

Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. (Allam H, Aoki K, Benigno BB, McDonald JF, Mackintosh SG, Tiemeyer M, Abbott KL) J Proteome Res 2015 Jan 02;14(1):434-46 PMID: 25437919 PMCID: PMC4286206 SCOPUS ID: 2-s2.0-84920278040 12/02/2014 47 Citations

Qrator: a web-based curation tool for glycan structures. (Eavenson M, Kochut KJ, Miller JA, Ranzinger R, Tiemeyer M, Aoki K, York WS) Glycobiology 2015 Jan;25(1):66-73 PMID: 25165068 PMCID: PMC4245907 SCOPUS ID: 2-s2.0-84945195097 08/29/2014 8 Citations

Discrimination between adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysis. (Porterfield M, Zhao P, Han H, Cunningham J, Aoki K, Von Hoff DD, Demeure MJ, Pierce JM, Tiemeyer M, Wells L) J Proteome Res 2014 Feb 07;13(2):395-407 PMID: 24328148 PMCID: PMC3946306 SCOPUS ID: 2-s2.0-84893818437 12/18/2013 37 Citations

Selective exo-enzymatic labeling of N-glycans on the surface of living cells by recombinant ST6Gal I. (Mbua NE, Li X, Flanagan-Steet HR, Meng L, Aoki K, Moremen KW, Wolfert MA, Steet R, Boons GJ) Angew Chem Int Ed Engl 2013 Dec 02;52(49):13012-5 PMID: 24129959 PMCID: PMC3869382 SCOPUS ID: 2-s2.0-84888597910 10/17/2013 78 Citations

A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. (Boccuto L, Aoki K, Flanagan-Steet H, Chen CF, Fan X, Bartel F, Petukh M, Pittman A, Saul R, Chaubey A, Alexov E, Tiemeyer M, Steet R, Schwartz CE) Hum Mol Genet 2014 Jan 15;23(2):418-33 PMID: 24026681 PMCID: PMC3869362 SCOPUS ID: 2-s2.0-84892639259 09/13/2013 159 Citations

In-gel β-elimination and aqueous-organic partition for improved O- and sulfoglycomics. (Kumagai T, Katoh T, Nix DB, Tiemeyer M, Aoki K) Anal Chem 2013 Sep 17;85(18):8692-9 PMID: 23937624 PMCID: PMC4004059 SCOPUS ID: 2-s2.0-84884274063 08/14/2013 34 Citations

Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65. (Xiang Y, Zhang X, Nix DB, Katoh T, Aoki K, Tiemeyer M, Wang Y) Nat Commun 2013;4:1659 PMID: 23552074 PMCID: PMC3620728 SCOPUS ID: 2-s2.0-84877777009 04/05/2013 152 Citations

Erratum: Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65 (Nature Communications (2013) 4 (1659) DOI: 10.1038/ncomms2669) (Xiang Y, Zhang X, Nix DB, Katoh T, Aoki K, Tiemeyer M, Wang Y) Nature Communications 2013;4 SCOPUS ID: 2-s2.0-84893378857 01/01/2013 2 Citations

Stage-specific expression and antigenicity of glycoprotein glycans isolated from the human liver fluke, Opisthorchis viverrini. (Talabnin K, Aoki K, Saichua P, Wongkham S, Kaewkes S, Boons GJ, Sripa B, Tiemeyer M) Int J Parasitol 2013 Jan;43(1):37-50 PMID: 23174105 PMCID: PMC3547145 SCOPUS ID: 2-s2.0-84872389662 11/24/2012 19 Citations

Porcine sperm bind to specific 6-sialylated biantennary glycans to form the oviduct reservoir. (Kadirvel G, Machado SA, Korneli C, Collins E, Miller P, Bess KN, Aoki K, Tiemeyer M, Bovin N, Miller DJ) Biol Reprod 2012 Jun;87(6):147 PMID: 23115267 PMCID: PMC4435431 SCOPUS ID: 2-s2.0-84877675099 11/02/2012 66 Citations

Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. (Nairn AV, Aoki K, dela Rosa M, Porterfield M, Lim JM, Kulik M, Pierce JM, Wells L, Dalton S, Tiemeyer M, Moremen KW) J Biol Chem 2012 Nov 02;287(45):37835-56 PMID: 22988249 PMCID: PMC3488057 SCOPUS ID: 2-s2.0-84868315627 09/19/2012 91 Citations

Biosynthesis of the major brain gangliosides GD1a and GT1b. (Sturgill ER, Aoki K, Lopez PH, Colacurcio D, Vajn K, Lorenzini I, Majić S, Yang WH, Heffer M, Tiemeyer M, Marth JD, Schnaar RL) Glycobiology 2012 Oct;22(10):1289-301 PMID: 22735313 PMCID: PMC3425327 SCOPUS ID: 2-s2.0-84865529249 06/28/2012 114 Citations

A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis. (Reilly MC, Aoki K, Wang ZA, Skowyra ML, Williams M, Tiemeyer M, Doering TL) J Biol Chem 2011 Jul 29;286(30):26888-99 PMID: 21606487 PMCID: PMC3143648 SCOPUS ID: 2-s2.0-79960693645 05/25/2011 15 Citations

Glycomic analyses of mouse models of congenital muscular dystrophy. (Stalnaker SH, Aoki K, Lim JM, Porterfield M, Liu M, Satz JS, Buskirk S, Xiong Y, Zhang P, Campbell KP, Hu H, Live D, Tiemeyer M, Wells L) J Biol Chem 2011 Jun 17;286(24):21180-90 PMID: 21460210 PMCID: PMC3122180 SCOPUS ID: 2-s2.0-79958747454 04/05/2011 70 Citations

Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. (Baas S, Sharrow M, Kotu V, Middleton M, Nguyen K, Flanagan-Steet H, Aoki K, Tiemeyer M) Development 2011 Feb;138(3):553-63 PMID: 21205799 PMCID: PMC3014640 SCOPUS ID: 2-s2.0-78751490457 01/06/2011 22 Citations

Genetic and structural analysis of the glycoprotein and glycolipid glycans of drosophila melanogaster (Sharrow M, Aoki K, Baas S, Porterfield M, Tiemeyer M) Handbook of Glycomics 2010:329-345 SCOPUS ID: 2-s2.0-84882503179 12/01/2010 3 Citations

The glycomics of glycan glucuronylation in Drosophila melanogaster. (Aoki K, Tiemeyer M) Methods Enzymol 2010;480:297-321 PMID: 20816215 SCOPUS ID: 2-s2.0-77956162735 09/08/2010 39 Citations

Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. (Rendić D, Sharrow M, Katoh T, Overcarsh B, Nguyen K, Kapurch J, Aoki K, Wilson IB, Tiemeyer M) Glycobiology 2010 Nov;20(11):1353-65 PMID: 20688784 PMCID: PMC2980953 SCOPUS ID: 2-s2.0-77957850844 08/07/2010 25 Citations

Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. (Stalnaker SH, Hashmi S, Lim JM, Aoki K, Porterfield M, Gutierrez-Sanchez G, Wheeler J, Ervasti JM, Bergmann C, Tiemeyer M, Wells L) J Biol Chem 2010 Aug 06;285(32):24882-91 PMID: 20507986 PMCID: PMC2915724 SCOPUS ID: 2-s2.0-77955286333 05/29/2010 89 Citations

IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. (Orlando R, Lim JM, Atwood JA 3rd, Angel PM, Fang M, Aoki K, Alvarez-Manilla G, Moremen KW, York WS, Tiemeyer M, Pierce M, Dalton S, Wells L) J Proteome Res 2009 Aug;8(8):3816-23 PMID: 19449840 PMCID: PMC4141490 SCOPUS ID: 2-s2.0-68549133585 05/20/2009 110 Citations

Phosphocholine-containing glycosyl inositol-phosphoceramides from Trichoderma viride induce defense responses in cultured rice cells. (Uchiyama R, Aoki K, Sugimoto H, Taka N, Katayama T, Itonori S, Sugita M, Che FS, Kumagai H, Yamamoto K) Biosci Biotechnol Biochem 2009 Jan;73(1):74-8 PMID: 19129653 SCOPUS ID: 2-s2.0-58849096299 01/09/2009 11 Citations

Mapping glycans onto specific N-linked glycosylation sites of Pyrus communis PGIP redefines the interface for EPG-PGIP interactions. (Lim JM, Aoki K, Angel P, Garrison D, King D, Tiemeyer M, Bergmann C, Wells L) J Proteome Res 2009 Feb;8(2):673-80 PMID: 19072240 PMCID: PMC4141487 SCOPUS ID: 2-s2.0-61849140680 12/17/2008 20 Citations

The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. (Aoki K, Porterfield M, Lee SS, Dong B, Nguyen K, McGlamry KH, Tiemeyer M) J Biol Chem 2008 Oct 31;283(44):30385-400 PMID: 18725413 PMCID: PMC2573061 SCOPUS ID: 2-s2.0-57149096197 08/30/2008 128 Citations

E-selectin receptors on human leukocytes. (Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, Von Seggern CE, Cotter RJ, Bochner BS, Tiemeyer M, Konstantopoulos K, Schnaar RL) Blood 2008 Nov 01;112(9):3744-52 PMID: 18579791 PMCID: PMC2572800 SCOPUS ID: 2-s2.0-55749095702 06/27/2008 133 Citations

Structural characterization of glycosylinositolphospholipids with a blood group type B sugar unit from the edible mushroom, Hypsizygus marmoreus. (Itonori S, Yamawaki S, Aoki K, Yamamoto K, Hada N, Takeda T, Dulaney JT, Sugita M) Glycobiology 2008 Jul;18(7):540-8 PMID: 18450973 SCOPUS ID: 2-s2.0-45749127034 05/03/2008 7 Citations

Targeted glycoproteomic identification of biomarkers for human breast carcinoma. (Abbott KL, Aoki K, Lim JM, Porterfield M, Johnson R, O'Regan RM, Wells L, Tiemeyer M, Pierce M) J Proteome Res 2008 Apr;7(4):1470-80 PMID: 18271524 PMCID: PMC4932838 SCOPUS ID: 2-s2.0-45549095820 02/15/2008 91 Citations

Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster. (Koles K, Lim JM, Aoki K, Porterfield M, Tiemeyer M, Wells L, Panin V) Glycobiology 2007 Dec;17(12):1388-403 PMID: 17893096 SCOPUS ID: 2-s2.0-36248936100 09/26/2007 88 Citations

Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. (Aoki K, Perlman M, Lim JM, Cantu R, Wells L, Tiemeyer M) J Biol Chem 2007 Mar 23;282(12):9127-42 PMID: 17264077 SCOPUS ID: 2-s2.0-34247849493 02/01/2007 246 Citations

Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences. (Aoki K, Uchiyama R, Yamauchi S, Katayama T, Itonori S, Sugita M, Hada N, Yamada-Hada J, Takeda T, Kumagai H, Yamamoto K) J Biol Chem 2004 Jul 30;279(31):32028-34 PMID: 15155728 SCOPUS ID: 2-s2.0-3543011963 05/25/2004 32 Citations

structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentus fungi: (2). Spectral analysis of the sugar-inositol portion by 2D-NMR. (Yamada-Hada J, Hada N, Aoki K, Yamamoto K, Takeda T) Chem Pharm Bull (Tokyo) 2004 Apr;52(4):473-6 PMID: 15056970 SCOPUS ID: 2-s2.0-4444295488 04/02/2004 3 Citations

Structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentous fungi and their induction of cell death of cultured rice cells. (Aoki K, Uchiyama R, Itonori S, Sugita M, Che FS, Isogai A, Hada N, Hada J, Takeda T, Kumagai H, Yamamoto K) Biochem J 2004 Mar 01;378(Pt 2):461-72 PMID: 14583095 PMCID: PMC1223952 SCOPUS ID: 2-s2.0-12144286542 10/30/2003 29 Citations

Purification and characterization of thermostable alpha-galactosidase from Ganoderma lucidum. (Sripuan T, Aoki K, Yamamoto K, Tongkao D, Kumagai H) Biosci Biotechnol Biochem 2003 Jul;67(7):1485-91 PMID: 12913291 SCOPUS ID: 2-s2.0-2442419823 08/13/2003 49 Citations

Glycotechnology and glycobiology of filamentous fungi (Yamamoto K, Aoki K, Makimura Y, Fujita K) Nippon Nogeikagaku Kaishi 2003;77(10):998-1000 SCOPUS ID: 2-s2.0-0344304565 01/01/2003

Classification into a Novel Mollu-Series of Neutral Glycosphingolipids from the Lamp Shell, Lingula unguis (Aoki K, Sugiyama S, Dulaney JT, Itonori S, Sugita M) Journal of Oleo Science 2002;51(7):463-472 SCOPUS ID: 2-s2.0-1542669733 01/01/2002 10 Citations

Structural characterization of a novel glycoinositolphospholipid from the parasitic nematode, Ascaris suum. (Sugita M, Mizunoma T, Aoki K, Dulaney JT, Inagaki F, Suzuki M, Suzuki A, Ichikawa S, Kushida K, Ohta S, Kurimoto A) Biochim Biophys Acta 1996 Aug 16;1302(3):185-92 PMID: 8765138 SCOPUS ID: 2-s2.0-0030590248 08/16/1996 25 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Kazuhiro Aoki PhD, MEd

Associate Professor

Publications (79)