Medical College of Wisconsin
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Kunal Gupta PhD, MBBS

Kunal Gupta PhD, MBBS profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Neurosurgery

Member of the Wisconsin Institute of NeuroScience (WINS)

View Curriculum Vitae

Research Areas of Interest

  • Epilepsy
  • Epilepsy, Temporal Lobe
  • Neurosciences

    • Publications (39)

  • Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy. (Helton C, Rodgers N, Gupta K) Biomed Pharmacother 2026 Aug;201:119737 PMID: 42401046 PMCID: PMC13479836 SCOPUS ID: 2-s2.0-105043578664 07/05/2026    
  • Development of an Educational Curriculum for the Surgical Implantation of DBS Systems. (Bieber D, Abdallah RT, Ab-Elsayed A, Burkey AR, Englot DJ, Gupta K, Munyon CN, Halpern CH, Miller KJ, Rosenow JM, Raslan AM, Slavin KV, Sweet JA, Sheth S, Tomycz N, Viswanathan A, Wu C, Raskin JS) Neuromodulation 2026 Jul;29(5):741-749 PMID: 42233936 SCOPUS ID: 2-s2.0-105040776657 06/03/2026    
  • Wnt activation prevents epileptogenic hippocampal remodeling in animal models of unilateral and bilateral temporal lobe epilepsy. (Helton C, Rodgers N, Gupta K) bioRxiv 2026 May 08 PMID: 42146596 PMCID: PMC13174431 05/18/2026    
  • Intracranial EEG findings and outcomes in MRI-negative epilepsy with temporal lobe semiology and scalp EEG features. (Pandya V, Janecek JK, LaRocque JJ, Thompson S, Bauer P, Vuppala A, Anderson C, Noviawaty I, Binder JR, Gupta K, Lew S, Mueller W, Greene C, Oleksy A, Swanson SJ, Carlson C, Raghavan M) Epilepsy Behav 2026 May;178:110963 PMID: 41719740 SCOPUS ID: 2-s2.0-105030272362 02/21/2026    
  • Effects of Deep Brain Stimulation on Adductor Laryngeal Dystonia. (Patel RR, Stall M, Halum S, Anthony B, Parker N, Reese M, Kareken D, Dickinson S, Witt TC, Purger DA, Gupta K, Zauber SE) Laryngoscope 2026 Jul;136(7):3085-3096 PMID: 41693579 PMCID: PMC13253171 SCOPUS ID: 2-s2.0-105030127907 02/16/2026       2 Citations
  • Spinal cord stimulation restores locomotion in a Parkinson's disease patient and rodents (Slack JC, Rees B, Borda E, Slack J, Nicolelis MAL, Zauber SE, Gupta K, Yadav AP) Brain Stimulation 1 September 2025;18(5):1407-1422 SCOPUS ID: 2-s2.0-105012757102 09/01/2025       2 Citations
  • Spinal cord stimulation restores locomotion in a Parkinson's disease patient and rodents. (Slack JC, Rees B, Borda E, Slack J, Nicolelis MAL, Zauber SE, Gupta K, Yadav AP) Brain Stimul 2025;18(5):1407-1422 PMID: 40759323 SCOPUS ID: 2-s2.0-105012757102 08/05/2025       2 Citations
  • A novel computational method for rodent electrographic recording and analysis using off-the-shelf intracerebral depth electrodes (Helton C, Rodgers N, Klosa P, Van Newenhizen E, Hodges M, Jones M, Gupta K) Methodsx June 2025;14 SCOPUS ID: 2-s2.0-85211994176 06/01/2025    
  • Development of an Educational Curriculum for Implanting and Managing Vagus Nerve Stimulators for Epilepsy. (Bieber D, Gupta K, Abdallah R, Abd-Elsayed A, Engle A, Duff I, Hoffman D, Kalia H, Rosenow J, Macken M, Raslan AM, Slavin K, Tennant A, Raskin JS) Neuromodulation 2025 Jun;28(4):551-557 PMID: 39969456 SCOPUS ID: 2-s2.0-85217976989 02/19/2025       3 Citations
  • A novel computational method for rodent electrographic recording and analysis using off-the-shelf intracerebral depth electrodes. (Helton C, Rodgers N, Klosa P, Van Newenhizen E, Hodges M, Jones M, Gupta K) MethodsX 2025 Jun;14:103106 PMID: 39790365 PMCID: PMC11714666 SCOPUS ID: 2-s2.0-85211994176 01/10/2025    
  • Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy (Mardones MD, Rostam KD, Nickerson MC, Gupta K) Experimental Neurology June 2024;376 SCOPUS ID: 2-s2.0-85188911182 06/01/2024       8 Citations
  • Bilateral Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus Improves Objective Acoustic Measures of Essential Vocal Tremor. (Patel R, Burroughs L, Higgins A, Zauber SE, Isbaine F, Schneider D, Hohman R, Gupta K) Neurosurgery 2024 Oct 01;95(4):915-923 PMID: 38787392 SCOPUS ID: 2-s2.0-85204179286 05/24/2024       4 Citations
  • Insights into epileptogenesis from post-traumatic epilepsy. (Pease M, Gupta K, Moshé SL, Correa DJ, Galanopoulou AS, Okonkwo DO, Gonzalez-Martinez J, Shutter L, Diaz-Arrastia R, Castellano JF) Nat Rev Neurol 2024 May;20(5):298-312 PMID: 38570704 PMCID: PMC12257072 SCOPUS ID: 2-s2.0-85189313072 04/04/2024       55 Citations
  • Canonical Wnt activator Chir99021 prevents epileptogenesis in the intrahippocampal kainate mouse model of temporal lobe epilepsy. (Mardones MD, Rostam KD, Nickerson MC, Gupta K) Exp Neurol 2024 Jun;376:114767 PMID: 38522659 PMCID: PMC11058011 SCOPUS ID: 2-s2.0-85188911182 03/25/2024       8 Citations
  • Susceptibility-Weighted MRI Approximates Intraoperative Microelectrode Recording During Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson's Disease. (Budnick HC, Schneider D, Zauber SE, Witt TC, Gupta K) World Neurosurg 2024 Jan;181:e346-e355 PMID: 37839566 SCOPUS ID: 2-s2.0-85176141861 10/16/2023       2 Citations
  • Transcriptome Profiling of the Hippocampal Seizure Network Implicates a Role for Wnt Signaling during Epileptogenesis in a Mouse Model of Temporal Lobe Epilepsy. (Mardones MD, Gupta K) Int J Mol Sci 2022 Oct 10;23(19) PMID: 36233336 PMCID: PMC9569502 SCOPUS ID: 2-s2.0-85139980008 10/15/2022       14 Citations
  • Case Report: Novel Anchoring Technique and Surgical Nuances for Trigeminal Ganglion Stimulation in the Treatment of Post-Herpetic Trigeminal Neuropathic Facial Pain. (Gupta K) Front Pain Res (Lausanne) 2022;3:835471 PMID: 35369537 PMCID: PMC8967959 SCOPUS ID: 2-s2.0-85142348327 04/05/2022       8 Citations
  • Globus Pallidus Interna and Ventral Intermediate Nucleus of the Thalamus Deep Brain Stimulation for Adductor Laryngeal Dystonia: a Case Report of Blinded Analyses of Objective Voice Outcomes in 2 Patients. (Patel RR, Zauber SE, Yadav AP, Witt TC, Halum S, Gupta K) Neurosurgery 2022 Apr 01;90(4):457-463 PMID: 35138294 SCOPUS ID: 2-s2.0-85126830952 02/10/2022       11 Citations
  • Commentary: Bilateral Nervus Intermedius Sectioning for Geniculate Neuralgia: Case Report and Operative Video. (Gupta K) Oper Neurosurg 2022 Jan 01;22(1):e64-e65 PMID: 34982926 SCOPUS ID: 2-s2.0-85123231495 01/05/2022    
  • Robot Assisted MRI-Guided LITT of the Anterior, Lateral, and Medial Temporal Lobe for Temporal Lobe Epilepsy. (Gupta K, Dickey AS, Hu R, Faught E, Willie JT) Front Neurol 2020;11:572334 PMID: 33329314 PMCID: PMC7729070 SCOPUS ID: 2-s2.0-85097507192 12/18/2020       12 Citations
  • Programming Parameters and Techniques in Trigeminal Ganglion Stimulation for Intractable Facial Pain. (Gupta K, Texakalidis P, Boulis NM) Neuromodulation 2021 Aug;24(6):1100-1106 PMID: 33145871 SCOPUS ID: 2-s2.0-85096685914 11/05/2020       10 Citations
  • Stereotactic MRI-guided laser interstitial thermal therapy for extratemporal lobe epilepsy. (Gupta K, Cabaniss B, Kheder A, Gedela S, Koch P, Hewitt KC, Alwaki A, Rich C, Ramesha S, Hu R, Drane DL, Gross RE, Willie JT) Epilepsia 2020 Aug;61(8):1723-1734 PMID: 32777090 PMCID: PMC8019400 SCOPUS ID: 2-s2.0-85089201160 08/11/2020       64 Citations
  • Novel Use of Stimulating Fence-Post Technique for Functional Mapping of Subcortical White Matter During Tumor Resection: A Technical Case Series. (Han SJ, Teton Z, Gupta K, Kawamoto A, Raslan AM) Oper Neurosurg 2020 Sep 01;19(3):264-270 PMID: 32133508 SCOPUS ID: 2-s2.0-85089608106 03/07/2020       7 Citations
  • Neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy. (Gupta K, Schnell E) PLoS One 2019;14(10):e0215789 PMID: 31596871 PMCID: PMC6785072 SCOPUS ID: 2-s2.0-85073053846 10/10/2019       18 Citations
  • Delivery Methods for Treatment of Genetic Disorders (Gupta K, Selden NR) Nervous System Drug Delivery Principles and Practice 25 June 2019:447-461 SCOPUS ID: 2-s2.0-85083811294 06/25/2019    
  • Lumbar laminotomy for the intrathecal administration of nusinersen for spinal muscular atrophy: technical note and outcomes. (Ko D, Blatt D, Karam C, Gupta K, Raslan AM) J Neurosurg Spine 2019 Aug 01;31(2):217-221 PMID: 31003222 SCOPUS ID: 2-s2.0-85073652817 04/20/2019       23 Citations
  • Cortical dysplasia and extratemporal resections in epilepsy (Gupta K, Selden NR) Functional Neurosurgery and Neuromodulation 1 January 2018:129-136 SCOPUS ID: 2-s2.0-85092587662 01/01/2018    
  • Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model. (Thelin EP, Hall CE, Gupta K, Carpenter KLH, Chandran S, Hutchinson PJ, Patani R, Helmy A) J Neurotrauma 2018 Jan 15;35(2):341-352 PMID: 28978285 PMCID: PMC5784793 SCOPUS ID: 2-s2.0-85041057115 10/06/2017       49 Citations
  • Intraoperative Computed Tomography and Nexframe-Guided Placement of Bilateral Hippocampal-Based Responsive Neurostimulation: Technical Note. (Gupta K, Raskin JS, Raslan AM) World Neurosurg 2017 May;101:161-169 PMID: 28185967 SCOPUS ID: 2-s2.0-85015657681 02/12/2017       7 Citations
  • Neurosurgical management in lateral meningocele syndrome: case report. (Brown EC, Gupta K, Sayama C) J Neurosurg Pediatr 2017 Feb;19(2):232-238 PMID: 27911244 SCOPUS ID: 2-s2.0-85013040208 12/03/2016       16 Citations
  • Atypical facial pain in multiple sclerosis caused by spinal cord seizures: a case report and review of the literature. (Gupta K, Burchiel KJ) J Med Case Rep 2016 Apr 20;10:101 PMID: 27095098 PMCID: PMC4837532 SCOPUS ID: 2-s2.0-84966286503 04/21/2016       7 Citations
  • Classification of middle fossa floor dehiscence syndromes. (Gupta K, Sabry HA, Dogan A, Coppa ND, McMenomey S, Delashaw JB, Raslan AM) J Neurosurg 2015 Mar;122(3):557-63 PMID: 25554855 SCOPUS ID: 2-s2.0-84927973270 01/03/2015       9 Citations
  • NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. (Gupta K, Hardingham GE, Chandran S) Neurosci Lett 2013 May 24;543:95-100 PMID: 23518152 PMCID: PMC3725411 SCOPUS ID: 2-s2.0-84877131133 03/23/2013       72 Citations
  • Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. (Gupta K, Chandran S, Hardingham GE) Br J Clin Pharmacol 2013 Apr;75(4):907-18 PMID: 23126226 PMCID: PMC3612708 SCOPUS ID: 2-s2.0-84875060374 11/07/2012       28 Citations
  • Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. (Gupta K, Patani R, Baxter P, Serio A, Story D, Tsujita T, Hayes JD, Pedersen RA, Hardingham GE, Chandran S) Cell Death Differ 2012 May;19(5):779-87 PMID: 22095276 PMCID: PMC3321621 SCOPUS ID: 2-s2.0-84859617138 11/19/2011       74 Citations
  • Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. (Bell KF, Al-Mubarak B, Fowler JH, Baxter PS, Gupta K, Tsujita T, Chowdhry S, Patani R, Chandran S, Horsburgh K, Hayes JD, Hardingham GE) Proc Natl Acad Sci U S A 2011 Jan 04;108(1):E1-2; author reply E3-4 PMID: 21177433 PMCID: PMC3017195 SCOPUS ID: 2-s2.0-78651099584 12/24/2010       124 Citations
  • Doctors: fighting fit or couch potatoes? (Gupta K, Fan L) Br J Sports Med 2009 Feb;43(2):153-4 PMID: 19050002 SCOPUS ID: 2-s2.0-61449199428 12/04/2008       20 Citations
  • Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. (Reynolds JL, Skepper JN, McNair R, Kasama T, Gupta K, Weissberg PL, Jahnen-Dechent W, Shanahan CM) J Am Soc Nephrol 2005 Oct;16(10):2920-30 PMID: 16093453 SCOPUS ID: 2-s2.0-33645269267 08/12/2005       320 Citations
  • Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. (Morris MR, Gentle D, Abdulrahman M, Maina EN, Gupta K, Banks RE, Wiesener MS, Kishida T, Yao M, Teh B, Latif F, Maher ER) Cancer Res 2005 Jun 01;65(11):4598-606 PMID: 15930277 SCOPUS ID: 2-s2.0-21144447438 06/03/2005       114 Citations
    • Last update: 09/04/2026