Medical College of Wisconsin
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Lan Zhu PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Program Development

Member of the Cancer Center

View Curriculum Vitae

Publications (18)

  • Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies. (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY) Nat Commun 2022 Jul 14;13(1):4095 PMID: 35835792 PMCID: PMC9283524 SCOPUS ID: 2-s2.0-85134147752 07/15/2022    
  • Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. (Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY) Nat Commun 2022 Feb 08;13(1):731 PMID: 35136060 PMCID: PMC8826421 SCOPUS ID: 2-s2.0-85124279039 02/10/2022       7 Citations
  • Serial Crystallography for Structure-Based Drug Discovery. (Zhu L, Chen X, Abola EE, Jing L, Liu W) Trends Pharmacol Sci 2020 Nov;41(11):830-839 PMID: 32950259 PMCID: PMC7572805 SCOPUS ID: 2-s2.0-85091103704 09/21/2020       5 Citations
  • Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor. (Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY) Mol Cell 2020 Oct 01;80(1):59-71.e4 PMID: 32818430 PMCID: PMC7541785 SCOPUS ID: 2-s2.0-85090205426 08/21/2020       32 Citations
  • Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED. (Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL) Structure 2020 Oct 06;28(10):1149-1159.e4 PMID: 32735770 PMCID: PMC7544639 SCOPUS ID: 2-s2.0-85089367384 08/01/2020       17 Citations
  • Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. (Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J) Sci Adv 2019 Jul;5(7):eaaw7935 PMID: 31355338 PMCID: PMC6656536 SCOPUS ID: 2-s2.0-85069936406 07/30/2019       50 Citations
  • High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source. (Martin-Garcia JM, Zhu L, Mendez D, Lee MY, Chun E, Li C, Hu H, Subramanian G, Kissick D, Ogata C, Henning R, Ishchenko A, Dobson Z, Zhang S, Weierstall U, Spence JCH, Fromme P, Zatsepin NA, Fischetti RF, Cherezov V, Liu W) IUCrJ 2019 May 01;6(Pt 3):412-425 PMID: 31098022 PMCID: PMC6503920 SCOPUS ID: 2-s2.0-85065335933 05/18/2019       30 Citations
  • Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor. (Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V) Nature 2019 May;569(7756):E6 PMID: 31048811 SCOPUS ID: 2-s2.0-85065291548 05/03/2019       1 Citation
  • Structural basis of ligand recognition at the human MT1 melatonin receptor. (Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V) Nature 2019 May;569(7755):284-288 PMID: 31019306 PMCID: PMC6696938 SCOPUS ID: 2-s2.0-85064887125 04/26/2019       108 Citations
  • XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity. (Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V) Nature 2019 May;569(7755):289-292 PMID: 31019305 PMCID: PMC6589158 SCOPUS ID: 2-s2.0-85064930899 04/26/2019       84 Citations
  • SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response. (Du SC, Zhu L, Wang YX, Liu J, Zhang D, Chen YL, Peng Q, Liu W, Liu B) Cancer Cell Int 2019;19:4 PMID: 30622440 PMCID: PMC6317191 SCOPUS ID: 2-s2.0-85059387641 01/10/2019       14 Citations
  • Solving protein structure from sparse serial microcrystal diffraction data at a storage-ring synchrotron source. (Lan TY, Wierman JL, Tate MW, Philipp HT, Martin-Garcia JM, Zhu L, Kissick D, Fromme P, Fischetti RF, Liu W, Elser V, Gruner SM) IUCrJ 2018 Sep 01;5(Pt 5):548-558 PMID: 30224958 PMCID: PMC6126656 SCOPUS ID: 2-s2.0-85053159147 09/19/2018       8 Citations
  • FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. (Li DZ, Liu SF, Zhu L, Wang YX, Chen YX, Liu J, Hu G, Yu X, Li J, Zhang J, Wu ZX, Lu H, Liu W, Liu B) Oncotarget 2017 Nov 14;8(57):97178-97186 PMID: 29228602 PMCID: PMC5722554 SCOPUS ID: 2-s2.0-85033786438 12/13/2017       7 Citations
  • Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation. (Martin-Garcia JM, Conrad CE, Nelson G, Stander N, Zatsepin NA, Zook J, Zhu L, Geiger J, Chun E, Kissick D, Hilgart MC, Ogata C, Ishchenko A, Nagaratnam N, Roy-Chowdhury S, Coe J, Subramanian G, Schaffer A, James D, Ketwala G, Venugopalan N, Xu S, Corcoran S, Ferguson D, Weierstall U, Spence JCH, Cherezov V, Fromme P, Fischetti RF, Liu W) IUCrJ 2017 Jul 01;4(Pt 4):439-454 PMID: 28875031 PMCID: PMC5571807 SCOPUS ID: 2-s2.0-85021805557 09/07/2017       100 Citations
  • Successful Strategies to Determine High-Resolution Structures of GPCRs. (Xiang J, Chun E, Liu C, Jing L, Al-Sahouri Z, Zhu L, Liu W) Trends Pharmacol Sci 2016 Dec;37(12):1055-1069 PMID: 27726881 SCOPUS ID: 2-s2.0-84992170625 10/12/2016       51 Citations
  • Serial Femtosecond Crystallography of Membrane Proteins. (Zhu L, Weierstall U, Cherezov V, Liu W) Adv Exp Med Biol 2016;922:151-160 PMID: 27553241 PMCID: PMC5110035 SCOPUS ID: 2-s2.0-84983781462 08/25/2016       6 Citations
  • Structure of the human P2Y12 receptor in complex with an antithrombotic drug. (Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W, Fenalti G, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q) Nature 2014 May 01;509(7498):115-8 PMID: 24670650 PMCID: PMC4174307 SCOPUS ID: 2-s2.0-84899755031 03/29/2014       291 Citations
  • Structure-based studies of chemokine receptors. (Zhu L, Zhao Q, Wu B) Curr Opin Struct Biol 2013 Aug;23(4):539-46 PMID: 23706951 SCOPUS ID: 2-s2.0-84881112796 05/28/2013       19 Citations
    • Last update: 12/07/2022