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Medical College of Wisconsin

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Lawrence M. Ryan MD

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Medicine Rheumatology

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Publications (104)

Hypophosphatasia: Biochemical hallmarks validate the expanded pediatric clinical nosology. (Whyte MP, Coburn SP, Ryan LM, Ericson KL, Zhang F) Bone 2018 May;110:96-106 PMID: 29360619 SCOPUS ID: 2-s2.0-85041627464 01/24/2018 54 Citations

Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature. (Sabchyshyn V, Konon I, Ryan LM, Rosenthal AK) Semin Arthritis Rheum 2018 Aug;48(1):9-11 PMID: 29338885 PMCID: PMC6240440 SCOPUS ID: 2-s2.0-85040444231 01/18/2018 22 Citations

Calcium Pyrophosphate Deposition Disease. (Rosenthal AK, Ryan LM) N Engl J Med 2016 Jun 30;374(26):2575-84 PMID: 27355536 PMCID: PMC6240444 SCOPUS ID: 2-s2.0-84976480156 06/30/2016 322 Citations

Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 2014 May;40(2):343-56 PMID: 24703351 PMCID: PMC6240445 SCOPUS ID: 2-s2.0-84898599073 04/08/2014 17 Citations

Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. (Uzuki M, Sawai T, Ryan LM, Rosenthal AK, Masuda I) J Rheumatol 2014 Jan;41(1):65-74 PMID: 24293574 PMCID: PMC6240442 SCOPUS ID: 2-s2.0-84891775364 12/03/2013 18 Citations

The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM) Arthritis Res Ther 2013 Oct 17;15(5):R154 PMID: 24286344 PMCID: PMC3978574 SCOPUS ID: 2-s2.0-84885537495 11/30/2013 39 Citations

An unusual cause of destructive monoarthritis. (Parperis KM, Ryan LM) J Clin Rheumatol 2013 Jun;19(4):225 PMID: 23669807 SCOPUS ID: 2-s2.0-84880055700 05/15/2013 1 Citation

The prevalence of chondrocalcinosis (CC) of the acromioclavicular (AC) joint on chest radiographs and correlation with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease. (Parperis K, Carrera G, Baynes K, Mautz A, Dubois M, Cerniglia R, Ryan LM) Clin Rheumatol 2013 Sep;32(9):1383-6 PMID: 23609408 PMCID: PMC5025023 SCOPUS ID: 2-s2.0-84883222016 04/24/2013 17 Citations

Hypophosphatasia: nonlethal disease despite skeletal presentation in utero (17 new cases and literature review). (Wenkert D, McAlister WH, Coburn SP, Zerega JA, Ryan LM, Ericson KL, Hersh JH, Mumm S, Whyte MP) J Bone Miner Res 2011 Oct;26(10):2389-98 PMID: 21713987 SCOPUS ID: 2-s2.0-80053176676 06/30/2011 124 Citations

Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it! (Rosenthal AK, Ryan LM) Nat Rev Rheumatol 2011 May;7(5):257-8 PMID: 21532639 SCOPUS ID: 2-s2.0-79955571641 05/03/2011 9 Citations

Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. (Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM) Osteoarthritis Cartilage 2010 Nov;18(11):1496-501 PMID: 20709180 PMCID: PMC2975862 SCOPUS ID: 2-s2.0-78149415406 08/17/2010 25 Citations

Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID: 20604715 SCOPUS ID: 2-s2.0-79952310245 07/08/2010 61 Citations

Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. (Whyte MP, Wenkert D, McAlister WH, Mughal MZ, Freemont AJ, Whitehouse R, Baildam EM, Coburn SP, Ryan LM, Mumm S) J Bone Miner Res 2009 Aug;24(8):1493-505 PMID: 19335222 SCOPUS ID: 2-s2.0-68949100637 04/02/2009 70 Citations

Effects of retinoic acid on Dominant hemimelia expression in mice. (Owen MH, Ryan LM, Holmes LB) Birth Defects Res A Clin Mol Teratol 2009 Jan;85(1):36-41 PMID: 19086026 SCOPUS ID: 2-s2.0-59849100128 12/17/2008 1 Citation

Combining individual- and group-level exposure information: child carbon monoxide in the Guatemala woodstove randomized control trial. (McCracken JP, Schwartz J, Bruce N, Mittleman M, Ryan LM, Smith KR) Epidemiology 2009 Jan;20(1):127-36 PMID: 19057384 SCOPUS ID: 2-s2.0-67651108828 12/06/2008 64 Citations

Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. (Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugl C, Ryan LM, Simkin P) Arthritis Rheum 2008 Oct;58(10):3270-4 PMID: 18821676 PMCID: PMC2574625 SCOPUS ID: 2-s2.0-54949138028 09/30/2008 18 Citations

Acute inflammatory syndrome following introduction of mycophenolate mofetil in a patient with systemic lupus erythematosus. (Konon I, Cronin ME, Ryan LM) Arthritis Rheum 2008 May 15;59(5):754-6 PMID: 18438909 SCOPUS ID: 2-s2.0-43549101620 04/29/2008 6 Citations

Tidal lavage in Milwaukee shoulder syndrome: do crystals make the difference? (Halverson PB, Ryan LM) J Rheumatol 2007 Jul;34(7):1446-7 PMID: 17611961 SCOPUS ID: 2-s2.0-34447550494 07/06/2007 6 Citations

Cementum and dentin in hypophosphatasia. (van den Bos T, Handoko G, Niehof A, Ryan LM, Coburn SP, Whyte MP, Beertsen W) J Dent Res 2005 Nov;84(11):1021-5 PMID: 16246934 SCOPUS ID: 2-s2.0-33644644712 10/26/2005 125 Citations

Modulation of chondrocyte production of extracellular inorganic pyrophosphate. (Costello JC, Ryan LM) Curr Opin Rheumatol 2004 May;16(3):268-72 PMID: 15103256 SCOPUS ID: 2-s2.0-1942531958 04/23/2004 21 Citations

Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease. (Williams CJ, Pendleton A, Bonavita G, Reginato AJ, Hughes AE, Peariso S, Doherty M, McCarty DJ, Ryan LM) Arthritis Rheum 2003 Sep;48(9):2627-31 PMID: 13130483 SCOPUS ID: 2-s2.0-0141788321 09/18/2003 64 Citations

Metabolism of extracellular pyrophosphate. (Ryan LM, Rosenthal AK) Curr Opin Rheumatol 2003 May;15(3):311-4 PMID: 12707586 SCOPUS ID: 2-s2.0-0038746715 04/23/2003 25 Citations

Marrow cell transplantation for infantile hypophosphatasia. (Whyte MP, Kurtzberg J, McAlister WH, Mumm S, Podgornik MN, Coburn SP, Ryan LM, Miller CR, Gottesman GS, Smith AK, Douville J, Waters-Pick B, Armstrong RD, Martin PL) J Bone Miner Res 2003 Apr;18(4):624-36 PMID: 12674323 SCOPUS ID: 2-s2.0-0041805439 04/04/2003 166 Citations

Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. (Hirose J, Ryan LM, Masuda I) Arthritis Rheum 2002 Dec;46(12):3218-29 PMID: 12483726 SCOPUS ID: 2-s2.0-0036899815 12/17/2002 77 Citations

Comparative calcification of native articular cartilage matrix vesicles and nitroprusside-generated vesicles. (Jaovisidha K, Hung J, Ning G, Ryan LM, Derfus BA) Osteoarthritis Cartilage 2002 Aug;10(8):646-52 PMID: 12479387 SCOPUS ID: 2-s2.0-0036670950 12/14/2002 8 Citations

The high prevalence of pathologic calcium crystals in pre-operative knees. (Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK) J Rheumatol 2002 Mar;29(3):570-4 PMID: 11908575 SCOPUS ID: 2-s2.0-0036197813 03/23/2002 179 Citations

Variations in site and levels of expression of chondrocyte nucleotide pyrophosphohydrolase with aging. (Masuda I, Iyama KI, Halligan BD, Barbieri JT, Haas AL, McCarty DJ, Ryan LM) J Bone Miner Res 2001 May;16(5):868-75 PMID: 11341331 SCOPUS ID: 2-s2.0-0035055433 05/09/2001 13 Citations

Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. (Derfus BA, Camacho NP, Olmez U, Kushnaryov VM, Westfall PR, Ryan LM, Rosenthal AK) Osteoarthritis Cartilage 2001 Apr;9(3):189-94 PMID: 11300741 SCOPUS ID: 2-s2.0-0035032346 04/13/2001 22 Citations

The ank gene story. (Ryan LM) Arthritis Res 2001;3(2):77-9 PMID: 11178113 PMCID: PMC128882 SCOPUS ID: 2-s2.0-0035083372 02/15/2001 37 Citations

Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase parallels the production of extracellular inorganic pyrophosphate in response to growth factors and with aging. (Hirose J, Masuda I, Ryan LM) Arthritis Rheum 2000 Dec;43(12):2703-11 PMID: 11145028 SCOPUS ID: 2-s2.0-0034545162 01/06/2001 29 Citations

Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia. (Fedde KN, Blair L, Silverstein J, Coburn SP, Ryan LM, Weinstein RS, Waymire K, Narisawa S, Millán JL, MacGregor GR, Whyte MP) J Bone Miner Res 1999 Dec;14(12):2015-26 PMID: 10620060 PMCID: PMC3049802 SCOPUS ID: 2-s2.0-0033386205 01/05/2000 368 Citations

Cellular responses to whitlockite. (Ryan LM, Cheung HS, LeGeros RZ, Kurup IV, Toth J, Westfall PR, McCarthy GM) Calcif Tissue Int 1999 Nov;65(5):374-7 PMID: 10541763 SCOPUS ID: 2-s2.0-0032696179 12/14/1999 29 Citations

Phosphocitrate blocks nitric oxide-induced calcification of cartilage and chondrocyte-derived apoptotic bodies. (Cheung HS, Ryan LM) Osteoarthritis Cartilage 1999 Jul;7(4):409-12 PMID: 10419783 SCOPUS ID: 2-s2.0-0033166176 07/27/1999 26 Citations

The role of crystals in osteoarthritis. (Ryan LM, Cheung HS) Rheum Dis Clin North Am 1999 May;25(2):257-67 PMID: 10356416 SCOPUS ID: 2-s2.0-0033066584 06/05/1999 52 Citations

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (Ryan LM, Kurup IV, Cheung HS) Arthritis Rheum 1999 Mar;42(3):555-60 PMID: 10088779 SCOPUS ID: 2-s2.0-0033014282 03/24/1999 24 Citations

Serum nucleotide pyrophosphohydrolase activity; elevated levels in osteoarthritis, calcium pyrophosphate crystal deposition disease, scleroderma, and fibromyalgia. (Cardenal A, Masuda I, Ono W, Haas AL, Ryan LM, Trotter D, McCarty DJ) J Rheumatol 1998 Nov;25(11):2175-80 PMID: 9818661 SCOPUS ID: 2-s2.0-0031762714 11/18/1998 11 Citations

Basic calcium phosphate crystal-induced collagenase production: role of intracellular crystal dissolution. (McCarthy GM, Cheung HS, Abel SM, Ryan LM) Osteoarthritis Cartilage 1998 May;6(3):205-13 PMID: 9682787 SCOPUS ID: 2-s2.0-0032076279 07/31/1998 32 Citations

Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts. (McCarthy GM, Macius AM, Christopherson PA, Ryan LM, Pourmotabbed T) Ann Rheum Dis 1998 Jan;57(1):56-60 PMID: 9536826 PMCID: PMC1752460 SCOPUS ID: 2-s2.0-0031900306 04/16/1998 18 Citations

Milwaukee shoulder with massive bilateral cysts: effective therapy for hydrops of the shoulder. (Patel KJ, Weidensaul D, Palma C, Ryan LM, Walker SE) J Rheumatol 1997 Dec;24(12):2479-83 PMID: 9415663 SCOPUS ID: 2-s2.0-0031452022 02/07/1998 11 Citations

Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophosphohydrolase. (Masuda I, Halligan BD, Barbieri JT, Haas AL, Ryan LM, McCarty DJ) Gene 1997 Sep 15;197(1-2):277-87 PMID: 9332376 SCOPUS ID: 2-s2.0-0030845712 10/23/1997 26 Citations

Inhibition of calcium pyrophosphate dihydrate crystal formation in articular cartilage vesicles and cartilage by phosphocitrate. (Cheung HS, Kurup IV, Sallis JD, Ryan LM) J Biol Chem 1996 Nov 08;271(45):28082-5 PMID: 8910421 SCOPUS ID: 2-s2.0-0029855054 11/08/1996 37 Citations

Adenosine triphosphate levels in human plasma. (Ryan LM, Rachow JW, McCarty BA, McCarty DJ) J Rheumatol 1996 Feb;23(2):214-9 PMID: 8882021 SCOPUS ID: 2-s2.0-0030009651 02/01/1996 25 Citations

Comparison of matrix vesicles derived from normal and osteoarthritic human articular cartilage. (Derfus BA, Kurtin SM, Camacho NP, Kurup I, Ryan LM) Connect Tissue Res 1996;35(1-4):337-42 PMID: 9084673 SCOPUS ID: 2-s2.0-0030430793 01/01/1996 47 Citations

Understanding inorganic pyrophosphate metabolism: toward prevention of calcium pyrophosphate dihydrate crystal deposition. (Ryan LM, McCarty DJ) Ann Rheum Dis 1995 Dec;54(12):939-41 PMID: 8546522 PMCID: PMC1010054 SCOPUS ID: 2-s2.0-0028791177 12/01/1995 47 Citations

Correction: A unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles. (Masuda I, Hamada J, Haas AL, Ryan LM, McCarthy DJ) J Clin Invest 1995 Aug;96(2):1179 PMID: 7635956 PMCID: PMC185310 SCOPUS ID: 2-s2.0-0029145924 08/01/1995

Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy. (Whyte MP, Landt M, Ryan LM, Mulivor RA, Henthorn PS, Fedde KN, Mahuren JD, Coburn SP) J Clin Invest 1995 Apr;95(4):1440-5 PMID: 7706447 PMCID: PMC295625 SCOPUS ID: 2-s2.0-0028914274 04/01/1995 165 Citations

A unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles. (Masuda I, Hamada J, Haas AL, Ryan LM, McCarty DJ) J Clin Invest 1995 Feb;95(2):699-704 PMID: 7860751 PMCID: PMC295537 SCOPUS ID: 2-s2.0-0028804435 02/01/1995 29 Citations

Treatment of refractory crystal-associated arthritis. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 1995 Feb;21(1):151-61 PMID: 7732165 SCOPUS ID: 2-s2.0-0028861779 02/01/1995 34 Citations

Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor beta1-stimulated chondrocytes and cartilage. (Olmez U, Ryan LM, Kurup IV, Rosenthal AK) Osteoarthritis Cartilage 1994 Sep;2(3):149-54 PMID: 11550674 SCOPUS ID: 2-s2.0-0028023246 09/01/1994 35 Citations

Synovial fluid and plasma levels of cartilage matrix glycoprotein in arthritis. (Fife RS, Rachow JW, Ryan LM) Calcif Tissue Int 1994 Aug;55(2):100-2 PMID: 7953973 SCOPUS ID: 2-s2.0-0028031123 08/01/1994 8 Citations

Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. (Rosenthal AK, Ryan LM) Mech Ageing Dev 1994 Jul;75(1):35-44 PMID: 9128752 SCOPUS ID: 2-s2.0-0028146172 07/01/1994 21 Citations

Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. (Rosenthal AK, Ryan LM) J Rheumatol 1994 May;21(5):896-900 PMID: 7520501 SCOPUS ID: 2-s2.0-0028237430 05/01/1994 45 Citations

Calcium pyrophosphate dihydrate crystal deposition and other crystal deposition diseases. (Ryan LM) Curr Opin Rheumatol 1993 Jul;5(4):517-21 PMID: 8357748 SCOPUS ID: 2-s2.0-0027227944 07/01/1993 10 Citations

Acute calcific periarthritis of the finger joints: a syndrome of women. (McCarthy GM, Carrera GF, Ryan LM) J Rheumatol 1993 Jun;20(6):1077-80 PMID: 8350318 SCOPUS ID: 2-s2.0-0027265269 06/01/1993 34 Citations

A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. (Rosenthal AK, McCarty BA, Cheung HS, Ryan LM) Arthritis Rheum 1993 Apr;36(4):539-42 PMID: 7681284 SCOPUS ID: 2-s2.0-0027461107 04/01/1993 36 Citations

Evidence that a 550,000-dalton cartilage matrix glycoprotein is a chondrocyte membrane-associated protein closely related to ceruloplasmin. (Fife RS, Kluve-Beckerman B, Houser DS, Proctor C, Liepnieks J, Masuda I, McCarty DJ, Ryan LM) J Biol Chem 1993 Feb 25;268(6):4407-11 PMID: 8440723 SCOPUS ID: 2-s2.0-0027417404 02/25/1993 12 Citations

ATP-induced chondrocalcinosis. (Ryan LM, Kurup IV, Derfus BA, Kushnaryov VM) Arthritis Rheum 1992 Dec;35(12):1520-5 PMID: 1472129 SCOPUS ID: 2-s2.0-0027074833 12/01/1992 52 Citations

Severe arthropathy and osteopathy following combined renal/pancreas transplantation. (Derfus BA, Carrera GF, Komorowski RA, Ryan LM) Transplantation 1992 Mar;53(3):678-81 PMID: 1549866 SCOPUS ID: 2-s2.0-0026590581 03/01/1992 3 Citations

Articular cartilage vesicles generate calcium pyrophosphate dihydrate-like crystals in vitro. (Derfus BA, Rachow JW, Mandel NS, Boskey AL, Buday M, Kushnaryov VM, Ryan LM) Arthritis Rheum 1992 Feb;35(2):231-40 PMID: 1734912 SCOPUS ID: 2-s2.0-0026532851 02/01/1992 91 Citations

Stimulation of cartilage inorganic pyrophosphate elaboration by ascorbate. (Ryan LM, Kurup I, Cheung HS) Matrix 1991 Aug;11(4):276-81 PMID: 1656174 SCOPUS ID: 2-s2.0-0025788687 08/01/1991 23 Citations

Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. (Rosenthal AK, Cheung HS, Ryan LM) Arthritis Rheum 1991 Jul;34(7):904-11 PMID: 1647773 SCOPUS ID: 2-s2.0-0025780585 07/01/1991 70 Citations

Synovial fluid ATP: a potential substrate for the production of inorganic pyrophosphate. (Ryan LM, Rachow JW, McCarty DJ) J Rheumatol 1991 May;18(5):716-20 PMID: 1650841 SCOPUS ID: 2-s2.0-0025739883 05/01/1991 117 Citations

Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis. (Rosenthal AK, Cheung HS, Ryan LM) J Lab Clin Med 1990 Mar;115(3):352-5 PMID: 2155981 SCOPUS ID: 2-s2.0-0025231561 03/01/1990 3 Citations

Cartilage inorganic pyrophosphate elaboration is independent of sulfated glycosaminoglycan synthesis. (Ryan LM, Kurup I, McCarty DJ, Cheung HS) Arthritis Rheum 1990 Feb;33(2):235-40 PMID: 2154998 SCOPUS ID: 2-s2.0-0025265590 02/01/1990 8 Citations

Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. (Ryan LM, Kurup I, Rosenthal AK, McCarty DJ) Arch Biochem Biophys 1989 Aug 01;272(2):393-9 PMID: 2546499 SCOPUS ID: 2-s2.0-0024384618 08/01/1989 7 Citations

Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. (Rosenthal AK, Cheung HS, Ryan LM) Arch Biochem Biophys 1989 Aug 01;272(2):386-92 PMID: 2546498 SCOPUS ID: 2-s2.0-0024365598 08/01/1989 4 Citations

Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. (Wortmann RL, Veum JA, Ryan LM, Cheung HS) Arthritis Rheum 1989 Aug;32(8):1014-21 PMID: 2788422 SCOPUS ID: 2-s2.0-0024450234 08/01/1989 1 Citation

Triple crystal disease: monosodium urate monohydrate, calcium pyrophosphate dihydrate, and basic calcium phosphate in a single joint. (Halverson PB, Ryan LM) Ann Rheum Dis 1988 Oct;47(10):864-5 PMID: 2848460 PMCID: PMC1003617 SCOPUS ID: 2-s2.0-0023788427 10/01/1988 6 Citations

Arthritis associated with calcium oxalate crystals in an anephric patient treated with peritoneal dialysis. (Rosenthal A, Ryan LM, McCarty DJ) JAMA 1988 Sep 02;260(9):1280-2 PMID: 3404640 SCOPUS ID: 2-s2.0-0023762168 09/02/1988 18 Citations

Inorganic pyrophosphate metabolism in arthritis. (Rachow JW, Ryan LM) Rheum Dis Clin North Am 1988 Aug;14(2):289-302 PMID: 2845490 SCOPUS ID: 2-s2.0-0023749442 08/01/1988 52 Citations

Synovial fluid inorganic pyrophosphate concentration and nucleotide pyrophosphohydrolase activity in basic calcium phosphate deposition arthropathy and Milwaukee shoulder syndrome. (Rachow JW, Ryan LM, McCarty DJ, Halverson PC) Arthritis Rheum 1988 Mar;31(3):408-13 PMID: 2833903 SCOPUS ID: 2-s2.0-0023928685 03/01/1988 53 Citations

Anterior pituitary involvement in Wegener's granulomatosis. (Lohr KM, Ryan LM, Toohill RJ, Anderson T) J Rheumatol 1988;15(5):855-7 PMID: 3172100 SCOPUS ID: 2-s2.0-0023899829 01/01/1988 29 Citations

Recurrent aseptic meningitis as a manifestation of mixed connective tissue disease (MCTD). (Harris GJ, Franson TR, Ryan LM) Wis Med J 1987 Mar;86(3):31-3 PMID: 3564518 SCOPUS ID: 2-s2.0-0023298842 03/01/1987 4 Citations

Rotator cuff tears: preliminary application of high-resolution MR imaging with counter rotating current loop-gap resonators. (Kneeland JB, Carrera GF, Middleton WD, Campagna NF, Ryan LM, Jesmanowicz A, Froncisz W, Hyde JS) Radiology 1986 Sep;160(3):695-9 PMID: 3737908 SCOPUS ID: 2-s2.0-0022518163 09/01/1986 20 Citations

Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease. (Ryan LM, Wortmann RL, Karas B, Lynch MP, McCarty DJ) J Clin Invest 1986 May;77(5):1689-93 PMID: 3009553 PMCID: PMC424575 SCOPUS ID: 2-s2.0-0022487212 05/01/1986 29 Citations

Increased serum pyridoxal-5'-phosphate in pseudohypophosphatasia. (Cole DE, Salisbury SR, Stinson RA, Coburn SP, Ryan LM, Whyte MP) N Engl J Med 1986 Apr 10;314(15):992-3 PMID: 3960066 SCOPUS ID: 2-s2.0-0022570453 04/10/1986 30 Citations

Ecto-nucleoside triphosphate pyrophosphohydrolase activity and calcium pyrophosphate dihydrate crystal deposition disease. (Wortmann RL, Ryan LM, Karas B, McCarthy DJ) Adv Exp Med Biol 1986;195 Pt A:153-6 PMID: 3014830 SCOPUS ID: 2-s2.0-0022498946 01/01/1986 5 Citations

Partial characterization of synovial fluid nucleotide pyrophosphohydrolase. (Rachow JW, Ryan LM) Arthritis Rheum 1985 Dec;28(12):1377-83 PMID: 2935159 SCOPUS ID: 2-s2.0-0022337186 12/01/1985 7 Citations

Adenosine triphosphate pyrophosphohydrolase and neutral inorganic pyrophosphatase in pathologic joint fluids. Elevated pyrophosphohydrolase in calcium pyrophosphate dihydrate crystal deposition disease. (Rachow JW, Ryan LM) Arthritis Rheum 1985 Nov;28(11):1283-8 PMID: 2998408 SCOPUS ID: 2-s2.0-0022344564 11/01/1985 40 Citations

Cartilage nucleoside triphosphate pyrophosphohydrolase. II. Role in extracellular pyrophosphate generation and nucleotide metabolism. (Ryan LM, Wortmann RL, Karas B, McCarty DJ Jr) Arthritis Rheum 1985 Apr;28(4):413-8 PMID: 2985090 SCOPUS ID: 2-s2.0-0021858466 04/01/1985 26 Citations

Milwaukee Shoulder syndrome: eleven additional cases with involvement of the knee in seven (basic calcium phosphate crystal deposition disease). (Halverson PB, McCarty DJ, Cheung HS, Ryan LM) Semin Arthritis Rheum 1984 Aug;14(1):36-44 PMID: 6484575 SCOPUS ID: 2-s2.0-0021601289 08/01/1984 52 Citations

Cartilage nucleoside triphosphate (NTP) pyrophosphohydrolase. I. Identification as an ecto-enzyme. (Ryan LM, Wortmann RL, Karas B, McCarty DJ Jr) Arthritis Rheum 1984 Apr;27(4):404-9 PMID: 6143564 SCOPUS ID: 2-s2.0-0021273747 04/01/1984 47 Citations

Acute erosive reactive arthritis associated with Campylobacter jejuni-induced colitis. (Ebright JR, Ryan LM) Am J Med 1984 Feb;76(2):321-3 PMID: 6695953 SCOPUS ID: 2-s2.0-0021338976 02/01/1984 34 Citations

Biological variation of rabbit chondrocyte 5'nucleotidase. (Wortmann RL, Ryan LM) Proc Soc Exp Biol Med 1983 Jul;173(3):349-54 PMID: 6306674 SCOPUS ID: 2-s2.0-0020560340 07/01/1983 5 Citations

The radiographic diagnosis of sacroiliitis. A comparison of different views with computed tomograms of the sacroiliac joint. (Ryan LM, Carrera GF, Lightfoot RW Jr, Hoffman RG, Kozin F) Arthritis Rheum 1983 Jun;26(6):760-3 PMID: 6860377 SCOPUS ID: 2-s2.0-0020631493 06/01/1983 57 Citations

Inorganic pyrophosphate levels in blood platelets from normal donors and patients with calcium pyrophosphate dihydrate crystal deposition disease. (Ryan LM, Lynch MP, McCarty DJ) Arthritis Rheum 1983 Apr;26(4):564-6 PMID: 6301512 SCOPUS ID: 2-s2.0-0020637232 04/01/1983 4 Citations

Infantile hypophosphatasia: enzyme replacement therapy by intravenous infusion of alkaline phosphatase-rich plasma from patients with Paget bone disease. (Whyte MP, Valdes R Jr, Ryan LM, McAlister WH) J Pediatr 1982 Sep;101(3):379-86 PMID: 7108657 SCOPUS ID: 2-s2.0-0019965925 09/01/1982 84 Citations

PRedominance of type II collagen in synovial chondromatosis. (Ryan LM, Cheung HS, Schwab JP, Johnson RP) Clin Orthop Relat Res 1982 Aug(168):173-7 PMID: 7105543 SCOPUS ID: 2-s2.0-0019993897 08/01/1982 7 Citations

Amyloid arthropathy: possible association with chondrocalcinosis. (Ryan LM, Liang G, Kozin F) J Rheumatol 1982;9(2):273-8 PMID: 7097685 SCOPUS ID: 2-s2.0-0020264230 03/01/1982 6 Citations

Computed tomography in the diagnosis of sacroiliitis. (Kozin F, Carrera GF, Ryan LM, Foley D, Lawson T) Arthritis Rheum 1981 Dec;24(12):1479-85 PMID: 6976786 SCOPUS ID: 2-s2.0-0019787691 12/01/1981 45 Citations

Release of pyrophosphate by normal mammalian articular hyaline and fibrocartilage in organ culture. (Ryan LM, Cheung HS, McCarty DJ) Arthritis Rheum 1981 Dec;24(12):1522-7 PMID: 6275863 SCOPUS ID: 2-s2.0-0019790796 12/01/1981 56 Citations

A method for determining DNA and chondrocyte content of articular cartilage. (Cheung HS, Ryan LM) Anal Biochem 1981 Sep 01;116(1):93-7 PMID: 6272614 SCOPUS ID: 2-s2.0-0019772052 09/01/1981 27 Citations

Bone scintigraphy in the reflex sympathetic dystrophy syndrome. (Kozin F, Soin JS, Ryan LM, Carrera GF, Wortmann RL) Radiology 1981 Feb;138(2):437-43 PMID: 7455127 SCOPUS ID: 2-s2.0-0019378374 02/01/1981 170 Citations

The reflex sympathetic dystrophy syndrome (RSDS). III. Scintigraphic studies, further evidence for the therapeutic efficacy of systemic corticosteroids, and proposed diagnostic criteria. (Kozin F, Ryan LM, Carerra GF, Soin JS, Wortmann RL) Am J Med 1981 Jan;70(1):23-30 PMID: 6109448 SCOPUS ID: 2-s2.0-0019352086 01/01/1981 248 Citations

Synovial origins of Rice bodies in joint fluid. (Cheung HS, Ryan LM, Kozin F, McCarty DJ) Arthritis Rheum 1980 Jan;23(1):72-6 PMID: 7352946 SCOPUS ID: 2-s2.0-0018913295 01/01/1980 67 Citations

Identification of collagen subtypes in synovial fluid sediments from arthritic patients. (Cheung HS, Ryan LM, Kozin F, McCarty DJ) Am J Med 1980 Jan;68(1):73-9 PMID: 7350807 SCOPUS ID: 2-s2.0-0018921339 01/01/1980 24 Citations

Concurrent linear scleroderma and systemic lupus erythematosus: a report of two cases. (Mackel SE, Kozin F, Ryan LM, Sheth KJ, Jordon RE) J Invest Dermatol 1979 Nov;73(5):368-72 PMID: 315439 SCOPUS ID: 2-s2.0-0018612979 11/01/1979 35 Citations

Quantification of human plasma inorganic pyrophosphate. II. Biologic variables. (Ryan LM, Kozin F, McCarty DJ) Arthritis Rheum 1979 Aug;22(8):892-5 PMID: 223578 SCOPUS ID: 2-s2.0-0018640893 08/01/1979 14 Citations

Quantification of human plasma inorganic pyrophosphate. I. Normal values in osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease. (Ryan LM, Kozin F, McCarty DJ) Arthritis Rheum 1979 Aug;22(8):886-91 PMID: 223577 SCOPUS ID: 2-s2.0-0018636286 08/01/1979 35 Citations

Rhabdomyolysis and renal failure in hypothyroidism. (Halverson PB, Kozin F, Ryan LM, Sulaiman AR) Ann Intern Med 1979 Jul;91(1):57-8 PMID: 464456 SCOPUS ID: 2-s2.0-0018770658 07/01/1979 42 Citations

High prevalence of HLA-Cw1 and Cw2 antigens in spondylarthritis. (Kozin F, Duquesnoy R, Rodey GE, Lightfoot RW, Ryan LM) Arthritis Rheum 1978;21(8):889-95 PMID: 737012 SCOPUS ID: 2-s2.0-0018216951 11/01/1978 10 Citations

Immune complex uveitis: a case. (Ryan LM, Kozin F, Eiferman R) Ann Intern Med 1978 Jan;88(1):62-3 PMID: 619761 SCOPUS ID: 2-s2.0-0017836729 01/01/1978 9 Citations

Phenformin and pancreatitis. (Ryan LM, Hankwitz P, Banasiak M) Ann Intern Med 1977 Dec;87(6):796 PMID: 931225 SCOPUS ID: 2-s2.0-0017595552 12/01/1977 4 Citations

Renal proximal tubular dysfunction and paroxysmal nocturnal hemoglobinuria. (Riley AL, Ryan LM, Roth DA) Am J Med 1977 Jan;62(1):125-9 PMID: 13653 SCOPUS ID: 2-s2.0-0017333026 01/01/1977 26 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Lawrence M. Ryan MD

Emeritus Professor

Publications (104)