Faculty Collaboration Database

Medical College of Wisconsin

CTSI Research Informatics REDCap

Meetha Medhora

Professor

Institution: Medical College of Wisconsin
Department: Radiation Oncology

Member of the Cardiovascular Research Center

Send Message

Request Meeting

View Curriculum Vitae

Publications (109)

Advances in noninvasive imaging for detecting radiation-induced lung injury (RILI). (Nissen A, Audi SH, Clough AV, Fish B, Joshi A, Medhora M, Sidabras JW, Himburg HA) Int J Radiat Biol 2025 Jul 15:1-13 PMID: 40663440 PMCID: PMC12344586 SCOPUS ID: 2-s2.0-105010955919 07/15/2025 3 Citations

2^nd Window NIR Imaging of Radiation Injury Mitigation Provided by Reduced Notch-Dll4 Expression on Vasculature. (Kondelaji MHR, Sharma GP, Jagtap J, Shafiee S, Hansen C, Gasperetti T, Frei A, Veley D, Narayanan J, Fish BL, Parchur AK, Ibrahim EH, Medhora M, Himburg HA, Joshi A) Mol Imaging Biol 2024 Feb;26(1):124-137 PMID: 37530966 PMCID: PMC11188939 SCOPUS ID: 2-s2.0-85166543488 08/02/2023 7 Citations

Introduction to the special issue for John E. Moulder, PhD. (Cohen EP, Fish BL, Medhora M) Int J Radiat Biol 2023;99(7):991-993 PMID: 37172306 SCOPUS ID: 2-s2.0-85160676530 05/12/2023

Biomarkers to Predict Lethal Radiation Injury to the Rat Lung. (Medhora M, Gao F, Gasperetti T, Narayanan J, Himburg H, Jacobs ER, Clough AV, Fish BL, Szabo A) Int J Mol Sci 2023 Mar 15;24(6) PMID: 36982722 PMCID: PMC10053311 SCOPUS ID: 2-s2.0-85152016549 03/30/2023 7 Citations

Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity. (Bansal S, Bansal S, Fish BL, Li Y, Xu X, Fernandez JA, Griffin JH, Himburg HA, Boerma M, Medhora M, Cheema AK) Int J Radiat Biol 2023;99(7):1109-1118 PMID: 36827630 PMCID: PMC10330346 SCOPUS ID: 2-s2.0-85148957703 02/25/2023 1 Citation

IPW-5371 mitigates the delayed effects of acute radiation exposure in WAG/RijCmcr rats when started 15 days after PBI with bone marrow sparing. (Fish BL, Hart B, Gasperetti T, Narayanan J, Gao F, Veley D, Pierce L, Himburg HA, MacVittie T, Medhora M) Int J Radiat Biol 2023;99(7):1119-1129 PMID: 36794325 PMCID: PMC10330589 SCOPUS ID: 2-s2.0-85148532473 02/17/2023 8 Citations

Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights. (Moulder JE, Cohen EP, Medhora M, Fish BL) Life Sci Space Res (Amst) 2022 Nov;35:60-68 PMID: 36336371 SCOPUS ID: 2-s2.0-85134465678 11/07/2022 7 Citations

Vascular regression in the kidney: changes in 3D vessel structure with time post-irradiation. (Mostaghimi S, Mehrvar S, Foomani FH, Narayanan J, Fish B, Camara AKS, Medhora M, Ranji M) Biomed Opt Express 2022 Aug 01;13(8):4338-4352 PMID: 36032582 PMCID: PMC9408260 SCOPUS ID: 2-s2.0-85135417365 08/30/2022

An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure. (Hinzman CP, Jayatilake M, Bansal S, Fish BL, Li Y, Zhang Y, Bansal S, Girgis M, Iliuk A, Xu X, Fernandez JA, Griffin JH, Ballew EA, Unger K, Boerma M, Medhora M, Cheema AK) J Transl Med 2022 May 10;20(1):199 PMID: 35538547 PMCID: PMC9092707 SCOPUS ID: 2-s2.0-85129903646 05/11/2022 11 Citations

Lisinopril Mitigates Radiation-Induced Mitochondrial Defects in Rat Heart and Blood Cells. (Ortiz de Choudens S, Sparapani R, Narayanan J, Lohr N, Gao F, Fish BL, Zielonka M, Gasperetti T, Veley D, Beyer A, Olson J, Jacobs ER, Medhora M) Front Oncol 2022;12:828177 PMID: 35311118 PMCID: PMC8924663 SCOPUS ID: 2-s2.0-85126780777 03/22/2022 5 Citations

Pharmacologic ACE-Inhibition Mitigates Radiation-Induced Pneumonitis by Suppressing ACE-Expressing Lung Myeloid Cells. (Sharma GP, Fish BL, Frei AC, Narayanan J, Gasperetti T, Scholler D, Pierce L, Szalewski N, Blue N, Medhora M, Himburg HA) Int J Radiat Oncol Biol Phys 2022 May 01;113(1):177-191 PMID: 35093482 PMCID: PMC9018504 SCOPUS ID: 2-s2.0-85125928392 01/31/2022 29 Citations

Autophagy, TERT, and mitochondrial dysfunction in hyperoxia. (Beyer AM, Norwood Toro LE, Hughes WE, Young M, Clough AV, Gao F, Medhora M, Audi SH, Jacobs ER) Am J Physiol Heart Circ Physiol 2021 Nov 01;321(5):H985-H1003 PMID: 34559580 PMCID: PMC8616608 SCOPUS ID: 2-s2.0-85120657950 09/25/2021 31 Citations

Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. (Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M) Health Phys 2021 Oct 01;121(4):419-433 PMID: 34546222 PMCID: PMC8577554 SCOPUS ID: 2-s2.0-85117425987 09/22/2021 36 Citations

Evaluation of Radiation-induced Pleural Effusions after Radiotherapy to Support Development of Animal Models of Radiation Pneumonitis. (Aqeel M, Medhora M, Gore E, Borkenhagen J, Klawikowski S, Eastwood D, Banerjee A, Jacobs ER) Health Phys 2021 Oct 01;121(4):434-443 PMID: 34546223 PMCID: PMC8500166 SCOPUS ID: 2-s2.0-85117425583 09/22/2021 4 Citations

Corrigendum: Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes. (Gasperetti T, Miller T, Gao F, Narayanan J, Jacobs ER, Szabo A, Cox GN, Orschell CM, Fish BL, Medhora M) Front Pharmacol 2021;12:741485 PMID: 34512365 PMCID: PMC8424069 SCOPUS ID: 2-s2.0-85114725296 09/14/2021 4 Citations

Molecular Changes in miRNA in Irradiated Rat Kidneys: Role of miR-34a and its Vascular Targets in the Notch Pathway. (Gao F, Dong W, Liu P, Narayanan J, Fish BL, Jacobs ER, Medhora M) Radiat Res 2021 Dec 01;196(6):611-622 PMID: 34330145 PMCID: PMC10416360 SCOPUS ID: 2-s2.0-85121150131 07/31/2021 8 Citations

Three-dimensional vascular and metabolic imaging using inverted autofluorescence. (Mehrvar S, Mostaghimi S, Camara AK, Foomani F, Narayanan J, Fish B, Medhora M, Ranji M) J Biomed Opt 2021 Jul;26(7) PMID: 34240589 PMCID: PMC8265174 SCOPUS ID: 2-s2.0-85111044448 07/10/2021 9 Citations

Long-acting PGE2 and Lisinopril Mitigate H-ARS. (Saunders J, Niswander LM, McGrath KE, Koniski A, Catherman SC, Ture SK, Medhora M, Kingsley PD, Calvi LM, Williams JP, Morrell CN, Palis J) Radiat Res 2021 Sep 01;196(3):284-296 PMID: 34153091 PMCID: PMC8516355 SCOPUS ID: 2-s2.0-85114297506 06/22/2021 3 Citations

Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes. (Gasperetti T, Miller T, Gao F, Narayanan J, Jacobs ER, Szabo A, Cox GN, Orschell CM, Fish BL, Medhora M) Front Pharmacol 2021;12:634477 PMID: 34079456 PMCID: PMC8165380 SCOPUS ID: 2-s2.0-85107216407 06/04/2021 25 Citations

Radiation Increases Bioavailability of Lisinopril, a Mitigator of Radiation-Induced Toxicities. (Medhora M, Phadnis P, Narayanan J, Gasperetti T, Zielonka J, Moulder JE, Fish BL, Szabo A) Front Pharmacol 2021;12:646076 PMID: 33986677 PMCID: PMC8111401 SCOPUS ID: 2-s2.0-85105645466 05/15/2021 4 Citations

Vascular Injury in Lung Vessels Post-radiation: A Dose and Time Response Case Study (Mostaghimi S, Mehrvar S, Foomani F, Narayanan J, Camara AKS, Fish B, Medhora M, Ranji M) 2021 Conference on Lasers and Electro Optics CLEO 2021 Proceedings May 2021 SCOPUS ID: 2-s2.0-85120464073 05/01/2021

A rapid dynamic in vivo near-infrared fluorescence imaging assay to track lung vascular permeability after acute radiation injury. (Jagtap J, Audi S, Razeghi-Kondelaji MH, Fish BL, Hansen C, Narayan J, Gao F, Sharma G, Parchur AK, Banerjee A, Bergom C, Medhora M, Joshi A) Am J Physiol Lung Cell Mol Physiol 2021 Mar 01;320(3):L436-L450 PMID: 33404364 PMCID: PMC8294617 SCOPUS ID: 2-s2.0-85102602723 01/07/2021 16 Citations

Vascular injury in lung vessels post-radiation: A dose and time response case study (Mostaghimi S, Mehrvar S, Foomani F, Narayanan J, Camara AKS, Fish B, Medhora M, Ranji M) Optics Infobase Conference Papers 2021 SCOPUS ID: 2-s2.0-85119399613 01/01/2021

Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril. (Medhora M, Gasperetti T, Schamerhorn A, Gao F, Narayanan J, Lazarova Z, Jacobs ER, Tarima S, Fish BL) Int J Mol Sci 2020 May 30;21(11) PMID: 32486174 PMCID: PMC7312718 SCOPUS ID: 2-s2.0-85085909627 06/04/2020 13 Citations

Prophylactic supplementation of 20-HETE ameliorates hypoxia/reoxygenation injury in pulmonary vascular endothelial cells by inhibiting apoptosis. (Sugumaran P, Narayanan V, Zhu D, Medhora M, Jacobs ER, Chandramohan Y, Selvaraj V, Dhanasekaran A) Acta Histochem 2020 Jan;122(1):151461 PMID: 31706620 SCOPUS ID: 2-s2.0-85075466040 11/11/2019 12 Citations

Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril. (Mehrvar S, la Cour MF, Medhora M, Camara AKS, Ranji M) Ann Biomed Eng 2019 Jul;47(7):1564-1574 PMID: 30963380 SCOPUS ID: 2-s2.0-85064248795 04/10/2019 23 Citations

Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3. (Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C) Am J Physiol Heart Circ Physiol 2019 Jun 01;316(6):H1267-H1280 PMID: 30848680 PMCID: PMC6620678 SCOPUS ID: 2-s2.0-85066837925 03/09/2019 37 Citations

Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril. (Jacobs ER, Narayanan J, Fish BL, Gao F, Harmann LM, Bergom C, Gasperetti T, Strande JL, Medhora M) Health Phys 2019 Apr;116(4):558-565 PMID: 30624347 PMCID: PMC6384144 SCOPUS ID: 2-s2.0-85061215751 01/10/2019 23 Citations

Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril. (Medhora M, Gao F, Gasperetti T, Narayanan J, Khan AH, Jacobs ER, Fish BL) Health Phys 2019 Apr;116(4):529-545 PMID: 30624354 PMCID: PMC6384142 SCOPUS ID: 2-s2.0-85061959951 01/10/2019 54 Citations

Effects of Diet on Late Radiation Injuries in Rats. (Moulder JE, Fish BL, Cohen EP, Flowers JB, Medhora M) Health Phys 2019 Apr;116(4):566-570 PMID: 30624356 PMCID: PMC6384138 SCOPUS ID: 2-s2.0-85061974646 01/10/2019 9 Citations

WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP). (Fish BL, MacVittie TJ, Szabo A, Moulder JE, Medhora M) Int J Radiat Biol 2020 Jan;96(1):81-92 PMID: 30575429 SCOPUS ID: 2-s2.0-85060053811 12/24/2018 29 Citations

Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins. (Ma C, Beyer AM, Durand M, Clough AV, Zhu D, Norwood Toro L, Terashvili M, Ebben JD, Hill RB, Audi SH, Medhora M, Jacobs ER) Arterioscler Thromb Vasc Biol 2018 Mar;38(3):622-635 PMID: 29419407 PMCID: PMC5823793 SCOPUS ID: 2-s2.0-85047900228 02/09/2018 66 Citations

Optical metabolic imaging of irradiated rat heart exposed to ischemia-reperfusion injury. (la Cour MF, Mehrvar S, Heisner JS, Motlagh MM, Medhora M, Ranji M, Camara AKS) J Biomed Opt 2018 Jan;23(1):1-9 PMID: 29352564 PMCID: PMC5774173 SCOPUS ID: 2-s2.0-85040834320 01/21/2018 17 Citations

Optical cryoimaging for assessment of radiation-induced injury to rat kidney metabolic state (Mehrvar S, Funding La Cour M, Medhora M, Camara AKS, Ranji M) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2018;10497 SCOPUS ID: 2-s2.0-85046372213 01/01/2018

Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. (Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV) Shock 2017 Oct;48(4):467-476 PMID: 28915216 PMCID: PMC5636640 SCOPUS ID: 2-s2.0-85017424389 09/16/2017 27 Citations

Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats. (Gao F, Liu P, Narayanan J, Yang M, Fish BL, Liu Y, Liang M, Jacobs ER, Medhora M) Sci Rep 2017 Mar 17;7:44132 PMID: 28303893 PMCID: PMC5355888 SCOPUS ID: 2-s2.0-85015404996 03/18/2017 32 Citations

Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 Feb;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 SCOPUS ID: 2-s2.0-85014510215 03/08/2017 6 Citations

Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs. (Fish BL, Gao F, Narayanan J, Bergom C, Jacobs ER, Cohen EP, Moulder JE, Orschell CM, Medhora M) Health Phys 2016 Nov;111(5):410-9 PMID: 27682899 PMCID: PMC5065284 SCOPUS ID: 2-s2.0-84991056212 09/30/2016 61 Citations

Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging. (Medhora M, Haworth S, Liu Y, Narayanan J, Gao F, Zhao M, Audi S, Jacobs ER, Fish BL, Clough AV) J Nucl Med 2016 Aug;57(8):1296-301 PMID: 27033892 PMCID: PMC5053021 SCOPUS ID: 2-s2.0-84982816391 04/02/2016 37 Citations

99MTc-Hexamethylpropyleneamine Oxime Imaging for Early Detection of Acute Lung Injury in Rats Exposed to Hyperoxia or Lipopolysaccharide Treatment. (Audi SH, Clough AV, Haworth ST, Medhora M, Ranji M, Densmore JC, Jacobs ER) Shock 2016 Oct;46(4):420-30 PMID: 26974426 PMCID: PMC5014734 SCOPUS ID: 2-s2.0-84961231173 03/15/2016 22 Citations

Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling. (Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER) J Radiat Res 2015 Mar;56(2):248-60 PMID: 25368342 PMCID: PMC4380043 SCOPUS ID: 2-s2.0-84942308898 11/05/2014 41 Citations

Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs. (Medhora M, Gao F, Wu Q, Molthen RC, Jacobs ER, Moulder JE, Fish BL) Radiat Res 2014 Nov;182(5):545-55 PMID: 25361399 PMCID: PMC4261643 SCOPUS ID: 2-s2.0-84914166194 11/02/2014 49 Citations

Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage. (Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Medhora M, Hill RP) Int J Radiat Oncol Biol Phys 2014 Jul 15;89(4):722-8 PMID: 24867538 PMCID: PMC4146496 SCOPUS ID: 2-s2.0-84903312945 05/29/2014 44 Citations

Enhanced survival from radiation pneumonitis by combined irradiation to the skin. (Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M) Int J Radiat Biol 2014 Sep;90(9):753-61 PMID: 24827855 PMCID: PMC4380176 SCOPUS ID: 2-s2.0-84907045554 05/16/2014 10 Citations

Hypoxia preconditioning increases survival and decreases expression of Toll-like receptor 4 in pulmonary artery endothelial cells exposed to lipopolysaccharide. (Ali I, Nanchal R, Husnain F, Audi S, Konduri GG, Densmore JC, Medhora M, Jacobs ER) Pulm Circ 2013 Sep;3(3):578-88 PMID: 24618542 PMCID: PMC4070795 SCOPUS ID: 2-s2.0-84973361991 03/13/2014 19 Citations

Safety and blood sample volume and quality of a refined retro-orbital bleeding technique in rats using a lateral approach. (Sharma A, Fish BL, Moulder JE, Medhora M, Baker JE, Mader M, Cohen EP) Lab Anim (NY) 2014 Feb;43(2):63-6 PMID: 24451361 PMCID: PMC3989930 SCOPUS ID: 2-s2.0-84892989748 01/24/2014 86 Citations

Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation. (Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2013 Nov;180(5):546-52 PMID: 24131041 PMCID: PMC3895940 SCOPUS ID: 2-s2.0-84888141459 10/18/2013 50 Citations

Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? (Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z) Radiat Res 2013 Aug;180(2):216-21 PMID: 23819595 PMCID: PMC3824385 SCOPUS ID: 2-s2.0-84882242143 07/04/2013 4 Citations

Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung. (Gao F, Narayanan J, Joneikis C, Fish BL, Szabo A, Moulder JE, Molthen RC, Jacobs ER, Rao RN, Medhora M) Radiat Res 2013 Apr;179(4):465-74 PMID: 23480564 PMCID: PMC3697111 SCOPUS ID: 2-s2.0-84876241819 03/14/2013 16 Citations

Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. (Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER) Shock 2013 Mar;39(3):271-7 PMID: 23364425 PMCID: PMC3578046 SCOPUS ID: 2-s2.0-84874256858 02/01/2013 10 Citations

Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation. (Gao F, Fish BL, Szabo A, Doctrow SR, Kma L, Molthen RC, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2012 Nov;178(5):468-80 PMID: 23020094 PMCID: PMC3678766 SCOPUS ID: 2-s2.0-84868620912 10/02/2012 43 Citations

Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril. (Molthen RC, Wu Q, Fish BL, Moulder JE, Jacobs ER, Medhora MM) Respirology 2012 Nov;17(8):1261-8 PMID: 22882664 PMCID: PMC3848310 SCOPUS ID: 2-s2.0-84867930386 08/14/2012 30 Citations

Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. (Harland DR, Lorenz LD, Fay K, Dunn BE, Gruenloh SK, Narayanan J, Jacobs ER, Medhora M) Prostaglandins Leukot Essent Fatty Acids 2012;87(2-3):79-89 PMID: 22858445 PMCID: PMC3839254 SCOPUS ID: 2-s2.0-84865387236 08/04/2012 4 Citations

Dose-modifying factor for captopril for mitigation of radiation injury to normal lung. (Medhora M, Gao F, Fish BL, Jacobs ER, Moulder JE, Szabo A) J Radiat Res 2012 Jul;53(4):633-40 PMID: 22843631 PMCID: PMC3393339 SCOPUS ID: 2-s2.0-84872114086 07/31/2012 45 Citations

Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. (Jacobs ER, Bodiga S, Ali I, Falck AM, Falck JR, Medhora M, Dhanasekaran A) Exp Cell Res 2012 Oct 01;318(16):2143-52 PMID: 22687879 PMCID: PMC3749092 SCOPUS ID: 2-s2.0-84864296910 06/13/2012 10 Citations

Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax. (Kma L, Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M) J Radiat Res 2012;53(1):10-7 PMID: 22302041 PMCID: PMC3616750 SCOPUS ID: 2-s2.0-84857826425 02/04/2012 62 Citations

Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. (Ali I, Gruenloh S, Gao Y, Clough A, Falck JR, Medhora M, Jacobs ER) Ann Thorac Surg 2012 Jan;93(1):282-8 PMID: 22115333 PMCID: PMC3268555 SCOPUS ID: 2-s2.0-84055189348 11/26/2011 17 Citations

Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. (Medhora M, Gao F, Jacobs ER, Moulder JE) Respirology 2012 Jan;17(1):66-71 PMID: 22023053 PMCID: PMC3245332 SCOPUS ID: 2-s2.0-84255176558 10/26/2011 99 Citations

Salen Mn complexes mitigate radiation injury in normal tissues. (Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, Medhora M, Molthen R, Moulder JE, Sonis ST, Tofilon PJ, Doctrow SR) Anticancer Agents Med Chem 2011 May 01;11(4):359-72 PMID: 21453241 PMCID: PMC3814176 SCOPUS ID: 2-s2.0-79958116231 04/02/2011 64 Citations

Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs. (Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D) Hypertens Res 2011 May;34(5):630-9 PMID: 21307870 PMCID: PMC4548928 SCOPUS ID: 2-s2.0-79955600318 02/11/2011 19 Citations

Advances in mitigation of injuries from radiological terrorism or nuclear accidents (Moulder JE, Medhora M) Defence Science Journal March 2011;61(2):99-104 SCOPUS ID: 2-s2.0-79952254259 01/01/2011 6 Citations

Effects of a localized high-flow anastomosis between the aorta and left lower lobe pulmonary artery on great vessel flow and pulmonary arterial reactivity in the contralateral lung. (Somberg L, Nirula R, Bousamra M 2nd, Friesema J, Zhu D, Medhora M, Jacobs ER) J Thorac Cardiovasc Surg 2011 Feb;141(2):407-12 PMID: 21075384 PMCID: PMC3022966 SCOPUS ID: 2-s2.0-78751591713 11/16/2010 1 Citation

Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis. (Pfister S, Somberg L, Lowry T, Gao Y, Medhora M, Jacobs ER) J Thorac Cardiovasc Surg 2011 Feb;141(2):425-31 PMID: 21075383 PMCID: PMC3052931 SCOPUS ID: 2-s2.0-78751601116 11/16/2010 2 Citations

Lipopolysaccharide-induced cytokine expression in alveolar epithelial cells: role of PKCζ-mediated p47phox phosphorylation. (Leverence JT, Medhora M, Konduri GG, Sampath V) Chem Biol Interact 2011 Jan 15;189(1-2):72-81 PMID: 20920494 SCOPUS ID: 2-s2.0-79251550763 10/06/2010 31 Citations

Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID: 20604715 SCOPUS ID: 2-s2.0-79952310245 07/08/2010 61 Citations

8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. (Ma J, Zhang L, Li S, Liu S, Ma C, Li W, Falck JR, Manthati VL, Reddy DS, Medhora M, Jacobs ER, Zhu D) Exp Cell Res 2010 Aug 15;316(14):2340-53 PMID: 20493836 PMCID: PMC2927814 SCOPUS ID: 2-s2.0-77954386544 05/25/2010 22 Citations

Animal models for medical countermeasures to radiation exposure. (Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH) Radiat Res 2010 Apr;173(4):557-78 PMID: 20334528 PMCID: PMC3021126 SCOPUS ID: 2-s2.0-77950193944 03/26/2010 382 Citations

Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats. (Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2010 Apr;173(4):545-56 PMID: 20334527 PMCID: PMC2904484 SCOPUS ID: 2-s2.0-77950256999 03/26/2010 41 Citations

20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. (Bodiga S, Gruenloh SK, Gao Y, Manthati VL, Dubasi N, Falck JR, Medhora M, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2010 Apr;298(4):L564-74 PMID: 20061439 PMCID: PMC2853341 SCOPUS ID: 2-s2.0-77950334333 01/12/2010 32 Citations

Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis. (Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M) Int J Radiat Oncol Biol Phys 2009 Dec 01;75(5):1528-36 PMID: 19931735 PMCID: PMC2800372 SCOPUS ID: 2-s2.0-71649101555 11/26/2009 102 Citations

Imaging radiation pneumonitis in a rat model of a radiological terrorism incident (Molthen R, Wu QP, Krenz G, Medhora M, Jacobs E, Moulder JE) Progress in Biomedical Optics and Imaging Proceedings of SPIE 2009;7262 SCOPUS ID: 2-s2.0-67249145940 06/22/2009 1 Citation

8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier. (Sharma M, McCarthy ET, Reddy DS, Patel PK, Savin VJ, Medhora M, Falck JR) Prostaglandins Other Lipid Mediat 2009 Jun;89(1-2):43-51 PMID: 19480064 PMCID: PMC2835413 SCOPUS ID: 2-s2.0-65649089846 05/30/2009 42 Citations

Vascular injury after whole thoracic x-ray irradiation in the rat. (Ghosh SN, Wu Q, Mäder M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC) Int J Radiat Oncol Biol Phys 2009 May 01;74(1):192-9 PMID: 19362237 PMCID: PMC2745917 SCOPUS ID: 2-s2.0-64049089817 04/14/2009 63 Citations

Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM) J Mol Cell Cardiol 2009 Jun;46(6):978-88 PMID: 19336274 PMCID: PMC2796716 SCOPUS ID: 2-s2.0-67349200006 04/02/2009 45 Citations

20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. (Dhanasekaran A, Bodiga S, Gruenloh S, Gao Y, Dunn L, Falck JR, Buonaccorsi JN, Medhora M, Jacobs ER) Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H777-86 PMID: 19136601 PMCID: PMC2660237 SCOPUS ID: 2-s2.0-64049113217 01/13/2009 45 Citations

Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. (Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M) J Mol Cell Cardiol 2009 Jan;46(1):4-14 PMID: 18930064 PMCID: PMC2640422 SCOPUS ID: 2-s2.0-57149112732 10/22/2008 94 Citations

Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. (Ionova IA, Vásquez-Vivar J, Whitsett J, Herrnreiter A, Medhora M, Cooley BC, Pieper GM) Am J Physiol Heart Circ Physiol 2008 Nov;295(5):H2178-87 PMID: 18835915 PMCID: PMC2614582 SCOPUS ID: 2-s2.0-57049176060 10/07/2008 34 Citations

Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery. (Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, Lowry T, Nanchal R, Jacobs ER, Moulder JE, Medhora M) Int J Radiat Biol 2008 Jun;84(6):487-97 PMID: 18470747 PMCID: PMC2435093 SCOPUS ID: 2-s2.0-45849110724 05/13/2008 47 Citations

Irradiation of varying volumes of rat lung to same mean lung dose: a little to a lot or a lot to a little? (Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN, Medhora MM, Li XA) Int J Radiat Oncol Biol Phys 2008 Jul 01;71(3):838-47 PMID: 18439765 SCOPUS ID: 2-s2.0-44449123472 04/29/2008 31 Citations

20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. (Medhora M, Chen Y, Gruenloh S, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 May;294(5):L902-11 PMID: 18296498 PMCID: PMC2586843 SCOPUS ID: 2-s2.0-45849122077 02/26/2008 69 Citations

Role of JNK in network formation of human lung microvascular endothelial cells. (Medhora M, Dhanasekaran A, Pratt PF Jr, Cook CR, Dunn LK, Gruenloh SK, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 Apr;294(4):L676-85 PMID: 18263671 PMCID: PMC2904476 SCOPUS ID: 2-s2.0-42049122785 02/12/2008 18 Citations

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H724-35 PMID: 18055514 PMCID: PMC2443685 SCOPUS ID: 2-s2.0-39149128273 12/07/2007 165 Citations

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. (Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF) Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):19-29 PMID: 17164129 SCOPUS ID: 2-s2.0-33845313333 12/14/2006 47 Citations

VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. (Jacobs ER, Zhu D, Gruenloh S, Lopez B, Medhora M) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L369-77 PMID: 16679379 SCOPUS ID: 2-s2.0-33748435644 05/09/2006 29 Citations

Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. (Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L378-85 PMID: 16679377 SCOPUS ID: 2-s2.0-33748439111 05/09/2006 52 Citations

Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. (Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31 PMID: 16617127 SCOPUS ID: 2-s2.0-33746790148 04/18/2006 61 Citations

Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). (Dunn LK, Gruenloh SK, Dunn BE, Reddy DS, Falck JR, Jacobs ER, Medhora M) Anat Rec A Discov Mol Cell Evol Biol 2005 Aug;285(2):771-80 PMID: 15952186 SCOPUS ID: 2-s2.0-23244463577 06/14/2005 16 Citations

Mechanisms regulating cerebral blood flow as therapeutic targets. (Pratt PF, Medhora M, Harder DR) Curr Opin Investig Drugs 2004 Sep;5(9):952-6 PMID: 15503650 SCOPUS ID: 2-s2.0-13244257651 10/27/2004 32 Citations

Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. (Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER) Circ Res 2003 May 16;92(9):992-1000 PMID: 12690037 SCOPUS ID: 2-s2.0-0037687982 04/12/2003 143 Citations

Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR). (Michaelis UR, Fisslthaler B, Medhora M, Harder D, Fleming I, Busse R) FASEB J 2003 Apr;17(6):770-2 PMID: 12586744 SCOPUS ID: 2-s2.0-0037387681 02/15/2003 159 Citations

Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. (Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, Harder DR) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H215-24 PMID: 12388259 SCOPUS ID: 2-s2.0-0037230201 10/22/2002 109 Citations

Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. (Yu M, McAndrew RP, Al-Saghir R, Maier KG, Medhora M, Roman RJ, Jacobs ER) J Appl Physiol (1985) 2002 Oct;93(4):1391-9 PMID: 12235040 SCOPUS ID: 2-s2.0-0036785969 09/18/2002 40 Citations

CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. (Zhu D, Zhang C, Medhora M, Jacobs ER) J Appl Physiol (1985) 2002 Jul;93(1):330-7 PMID: 12070222 SCOPUS ID: 2-s2.0-0035986058 06/19/2002 56 Citations

Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling. (Medhora M, Bousamra M 2nd, Zhu D, Somberg L, Jacobs ER) Am J Physiol Heart Circ Physiol 2002 Feb;282(2):H414-22 PMID: 11788387 SCOPUS ID: 2-s2.0-0036084720 01/15/2002 37 Citations

Identifying endothelium-derived hyperpolarizing factor: recent approaches to assay the role of epoxyeicosatrienoic acids. (Medhora M, Narayanan J, Harder D, Maier KG) Jpn J Pharmacol 2001 Aug;86(4):369-75 PMID: 11569609 SCOPUS ID: 2-s2.0-0034830636 09/25/2001 20 Citations

Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. (Medhora M, Narayanan J, Harder D) Trends Cardiovasc Med 2001 Jan;11(1):38-42 PMID: 11413051 SCOPUS ID: 2-s2.0-0034970147 06/20/2001 52 Citations

Retinoic acid upregulates beta(1)-integrin in vascular smooth muscle cells and alters adhesion to fibronectin. (Medhora MM) Am J Physiol Heart Circ Physiol 2000 Jul;279(1):H382-7 PMID: 10899079 SCOPUS ID: 2-s2.0-0033855605 07/19/2000 31 Citations

Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). (Medhora M, Harder D) Int J Mol Med 1998 Dec;2(6):661-9 PMID: 9850733 SCOPUS ID: 2-s2.0-0032238183 12/16/1998 22 Citations

Regulation of integrin expression and function by retinoic acid in vascular smooth muscle cell lines (Medhora M, Harder D) FASEB Journal 1997;11(3):A266 SCOPUS ID: 2-s2.0-33750197821 12/01/1997

Transcriptional regulation of the (Medhora MM, Hruska KA, Harder DR) FASEB Journal 1996;10(3):A608 SCOPUS ID: 2-s2.0-33749181114 12/01/1996

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. (Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR) Stroke 1996 May;27(5):971-9 PMID: 8623121 SCOPUS ID: 2-s2.0-0029930387 05/01/1996 182 Citations

1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3. (Medhora MM, Teitelbaum S, Chappel J, Alvarez J, Mimura H, Ross FP, Hruska K) J Biol Chem 1993 Jan 15;268(2):1456-61 PMID: 7678259 SCOPUS ID: 2-s2.0-0027404099 01/15/1993 87 Citations

Molecular and functional analysis of the mariner mutator element Mos1 in Drosophila. (Medhora M, Maruyama K, Hartl DL) Genetics 1991 Jun;128(2):311-8 PMID: 1649068 PMCID: PMC1204469 SCOPUS ID: 2-s2.0-0026015009 06/01/1991 148 Citations

Introduction of the transposable element mariner into the germline of Drosophila melanogaster. (Garza D, Medhora M, Koga A, Hartl DL) Genetics 1991 Jun;128(2):303-10 PMID: 1649067 PMCID: PMC1204468 SCOPUS ID: 2-s2.0-0026015008 06/01/1991 94 Citations

Drosophila nonsense suppressors: functional analysis in Saccharomyces cerevisiae, Drosophila tissue culture cells and Drosophila melanogaster. (Garza D, Medhora MM, Hartl DL) Genetics 1990 Nov;126(3):625-37 PMID: 2174393 PMCID: PMC1204218 SCOPUS ID: 2-s2.0-0025119674 11/01/1990 10 Citations

Excision of the Drosophila transposable element mariner: identification and characterization of the Mos factor. (Medhora MM, MacPeek AH, Hartl DL) EMBO J 1988 Jul;7(7):2185-9 PMID: 2843360 PMCID: PMC454541 SCOPUS ID: 2-s2.0-0024042205 07/01/1988 59 Citations

Molecular structure of a somatically unstable transposable element in Drosophila. (Jacobson JW, Medhora MM, Hartl DL) Proc Natl Acad Sci U S A 1986 Nov;83(22):8684-8 PMID: 3022302 PMCID: PMC386995 SCOPUS ID: 2-s2.0-0011704558 11/01/1986 258 Citations

The evolution of DNA sequences in Escherichia coli. (Hartl DL, Medhora M, Green L, Dykhuizen DE) Philos Trans R Soc Lond B Biol Sci 1986 Jan 29;312(1154):191-204 PMID: 2870515 SCOPUS ID: 2-s2.0-0023058753 01/29/1986 20 Citations

Construction of a gene library from the nitrogen-fixing aerobe Azotobacter vinelandii. (Medhora M, Phadnis SH, Das HK) Gene 1983 Nov;25(2-3):355-60 PMID: 6319242 SCOPUS ID: 2-s2.0-0021048908 11/01/1983 6 Citations

Last update: 02/24/2026

© 2026 Clinical & Translational Science Institute
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53223

Publication and ontology data from NCBI | Disclaimer and Copyright

This site is a collaborative effort of the Medical College of Wisconsin and the Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number 2UL1TR001436) at the National Institutes of Health (NIH).

preservation

Faculty Collaboration Database

Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Meetha Medhora

Professor

Publications (109)