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Michele A. Battle PhD

Michele A. Battle PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center
Member of the Neuroscience Research Center


Research Experience

  • Anatomy
  • Animals
  • Animals, Laboratory
  • Biology
  • Cells
  • Cellular Structures
  • Chimera
  • Developmental Biology
  • Digestive System
  • Digestive System Abnormalities
  • Digestive System Diseases
  • Embryology
  • Epithelial Cells
  • Epithelium
  • Eukaryotic Cells
  • Gastrointestinal Diseases
  • Gastrointestinal Tract
  • Genetics
  • Liver
  • Molecular Biology
  • Organisms, Genetically Modified
  • Organoids
  • Pancreas
  • Stem Cells
  • Tissues
  • Publications (31)

  • GATA4 regulates epithelial morphogenesis in the developing mouse stomach to promote establishment of a glandular columnar epithelium (Ann DeLaForest, Bridget M. Kohlnhofer, Olivia D. Franklin, Roman Stavniichuk, Cayla A. Thompson, Kirthi Pulakanti, Sridhar Rao, Michele A. Battle) [preprint] BioRxiv 08/18/2020    
  • GATA4, expressed in Barrett’s esophagus and esophageal adenocarcinoma, can block squamous epithelial cell gene expression in human esophageal cells. (Roman Stavniichuk, Ann DeLaForest, Cayla A. Thompson, James Miller, Rhonda F. Souza, Michele A. Battle) [preprint] BioRxiv 06/17/2020    
  • H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients. (McCormick CA, Samuels TL, Battle MA, Frolkis T, Blumin JH, Bock JM, Wells C, Yan K, Altman KW, Johnston N) Laryngoscope 2020 Apr 06 PMID: 32250454 SCOPUS ID: 2-s2.0-85083103241 04/07/2020    
  • GATA4 Is Required for Budding Morphogenesis of Posterior Foregut Endoderm in a Model of Human Stomach Development. (DeLaForest A, Quryshi AF, Frolkis TS, Franklin OD, Battle MA) Front Med (Lausanne) 2020;7:44 PMID: 32140468 PMCID: PMC7042400 03/07/2020    
  • The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis. (Fields B, DeLaForest A, Zogg M, May J, Hagen C, Komnick K, Wieser J, Lundberg A, Weiler H, Battle MA, Carlson KS) Sci Rep 2019 12 17;9(1):19303 PMID: 31848396 PMCID: PMC6917708 SCOPUS ID: 2-s2.0-85076615345 12/19/2019       2 Citations
  • Patterning the gastrointestinal epithelium to confer regional-specific functions. (Thompson CA, DeLaForest A, Battle MA) Dev Biol 2018 03 15;435(2):97-108 PMID: 29339095 PMCID: PMC6615902 SCOPUS ID: 2-s2.0-85042765603 01/18/2018       13 Citations
  • GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine. (Thompson CA, Wojta K, Pulakanti K, Rao S, Dawson P, Battle MA) Cell Mol Gastroenterol Hepatol 2017 May;3(3):422-446 PMID: 28462382 PMCID: PMC5404030 05/04/2017    
  • Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. (Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM) Stem Cell Reports 2017 03 14;8(3):491-499 PMID: 28238794 PMCID: PMC5355643 SCOPUS ID: 2-s2.0-85013648619 02/28/2017       15 Citations
  • A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells. (Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR) Stem Cell Reports 2016 11 08;7(5):826-839 PMID: 27720905 PMCID: PMC5106483 SCOPUS ID: 2-s2.0-84992065194 10/11/2016       11 Citations
  • GATA4 regulates epithelial cell proliferation to control intestinal growth and development in mice. (Kohlnhofer BM, Thompson CA, Walker EM, Battle MA) Cell Mol Gastroenterol Hepatol 2016 Mar;2(2):189-209 PMID: 27066525 PMCID: PMC4823006 04/12/2016    
  • Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function. (Moore BD, Jin RU, Lo H, Jung M, Wang H, Battle MA, Wollheim CB, Urano F, Mills JC) J Biol Chem 2016 Mar 18;291(12):6146-57 PMID: 26792861 PMCID: PMC4813565 SCOPUS ID: 2-s2.0-84964891117 01/23/2016       16 Citations
  • Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. (Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ) J Neurosci 2015 May 13;35(19):7503-8 PMID: 25972176 PMCID: PMC4429154 SCOPUS ID: 2-s2.0-84929353508 05/15/2015       15 Citations
  • Characterization of the developing small intestine in the absence of either GATA4 or GATA6. (Walker EM, Thompson CA, Kohlnhofer BM, Faber ML, Battle MA) BMC Res Notes 2014 Dec 11;7:902 PMID: 25495347 PMCID: PMC4307969 SCOPUS ID: 2-s2.0-84928785787 12/17/2014       11 Citations
  • GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. (Walker EM, Thompson CA, Battle MA) Dev Biol 2014 Aug 15;392(2):283-94 PMID: 24929016 PMCID: PMC4149467 SCOPUS ID: 2-s2.0-84904397909 06/15/2014       34 Citations
  • Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. (Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L) J Clin Invest 2012 Oct;122(10):3516-28 PMID: 23006325 PMCID: PMC3461916 SCOPUS ID: 2-s2.0-84867174750 09/26/2012       93 Citations
  • E-cadherin is required for intestinal morphogenesis in the mouse. (Bondow BJ, Faber ML, Wojta KJ, Walker EM, Battle MA) Dev Biol 2012 Nov 01;371(1):1-12 PMID: 22766025 PMCID: PMC3455111 SCOPUS ID: 2-s2.0-84866479999 07/07/2012       47 Citations
  • Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis. (Patankar JV, Obrowsky S, Doddapattar P, Hoefler G, Battle M, Levak-Frank S, Kratky D) J Hepatol 2012 Nov;57(5):1061-8 PMID: 22750465 PMCID: PMC3477492 SCOPUS ID: 2-s2.0-84867570915 07/04/2012       11 Citations
  • Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. (Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P) Nat Med 2011 Nov 20;17(12):1585-93 PMID: 22101768 PMCID: PMC3902046 SCOPUS ID: 2-s2.0-84856083002 11/22/2011       231 Citations
  • HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. (DeLaForest A, Nagaoka M, Si-Tayeb K, Noto FK, Konopka G, Battle MA, Duncan SA) Development 2011 Oct;138(19):4143-53 PMID: 21852396 PMCID: PMC3171218 SCOPUS ID: 2-s2.0-80052448715 08/20/2011       128 Citations
  • Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice. (Patankar JV, Chandak PG, Obrowsky S, Pfeifer T, Diwoky C, Uellen A, Sattler W, Stollberger R, Hoefler G, Heinemann A, Battle M, Duncan S, Kratky D, Levak-Frank S) Am J Physiol Endocrinol Metab 2011 Mar;300(3):E478-88 PMID: 21177287 PMCID: PMC3163292 SCOPUS ID: 2-s2.0-79952144546 12/24/2010       11 Citations
  • The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver. (Chamouton J, Hansmannel F, Bonzo JA, Clémencet MC, Chevillard G, Battle M, Martin P, Pineau T, Duncan S, Gonzalez FJ, Latruffe N, Mandard S, Nicolas-Francès V) PPAR Res 2010;2010:352957 PMID: 21437216 PMCID: PMC3061263 01/01/2010    
  • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. (Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, North PE, Dalton S, Duncan SA) Hepatology 2010 Jan;51(1):297-305 PMID: 19998274 PMCID: PMC2946078 SCOPUS ID: 2-s2.0-73449100783 12/10/2009       789 Citations
  • Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. (Sun K, Battle MA, Misra RP, Duncan SA) Hepatology 2009 May;49(5):1645-54 PMID: 19205030 PMCID: PMC2810404 SCOPUS ID: 2-s2.0-66149117384 02/11/2009       21 Citations
  • GATA4 is essential for jejunal function in mice. (Battle MA, Bondow BJ, Iverson MA, Adams SJ, Jandacek RJ, Tso P, Duncan SA) Gastroenterology 2008 Nov;135(5):1676-1686.e1 PMID: 18812176 PMCID: PMC2844802 SCOPUS ID: 2-s2.0-55249123809 09/25/2008       62 Citations
  • Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. (Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA) Hepatology 2008 Oct;48(4):1242-50 PMID: 18704925 PMCID: PMC2717709 SCOPUS ID: 2-s2.0-54449091729 08/16/2008       60 Citations
  • Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. (Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA) Dev Biol 2008 May 15;317(2):614-9 PMID: 18400219 PMCID: PMC2423416 SCOPUS ID: 2-s2.0-43049103483 04/11/2008       143 Citations
  • Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. (Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA) Proc Natl Acad Sci U S A 2006 May 30;103(22):8419-24 PMID: 16714383 PMCID: PMC1482507 SCOPUS ID: 2-s2.0-33744795211 05/23/2006       180 Citations
  • Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. (Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA) Gastroenterology 2006 Apr;130(4):1207-20 PMID: 16618389 PMCID: PMC3581272 SCOPUS ID: 2-s2.0-33646477296 04/19/2006       113 Citations
  • Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. (Rufibach LE, Duncan SA, Battle M, Deeb SS) J Lipid Res 2006 Jul;47(7):1463-77 PMID: 16603721 SCOPUS ID: 2-s2.0-33746103335 04/11/2006       31 Citations
  • GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. (Watt AJ, Battle MA, Li J, Duncan SA) Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12573-8 PMID: 15310850 PMCID: PMC515098 SCOPUS ID: 2-s2.0-4344565788 08/18/2004       249 Citations
  • ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (Battle MA, Maher VM, McCormick JJ) Biochemistry 2003 Jun 24;42(24):7270-82 PMID: 12809483 SCOPUS ID: 2-s2.0-0038746904 06/18/2003       26 Citations
  • Last update: 10/20/2020
    jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a