Medical College of Wisconsin
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Nan Zhu PhD

Nan Zhu PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center


Publications (20)

  • Epigenetic regulation of protein translation in KMT2A-rearranged AML. (Lenard A, Xie HM, Pastuer T, Shank T, Libbrecht C, Kingsley M, Riedel SS, Yuan ZF, Zhu N, Neff T, Bernt KM) Exp Hematol 2020 05;85:57-69 PMID: 32437908 05/22/2020       1 Citation
  • CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance. (Chen Y, Yu M, Zheng Y, Fu G, Xin G, Zhu W, Luo L, Burns R, Li QZ, Dent AL, Zhu N, Cui W, Malherbe L, Wen R, Wang D) Nat Commun 2019 09 27;10(1):4415 PMID: 31562329 PMCID: PMC6765049 SCOPUS ID: 2-s2.0-85072692451 09/29/2019       6 Citations
  • Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia. (Izaguirre-Carbonell J, Christiansen L, Burns R, Schmitz J, Li C, Mokry RL, Bluemn T, Zheng Y, Shen J, Carlson KS, Rao S, Wang D, Zhu N) Blood Adv 2019 05 14;3(9):1499-1511 PMID: 31076406 PMCID: PMC6517669 SCOPUS ID: 2-s2.0-85068626845 05/12/2019       3 Citations
  • Stem cell damage after chemotherapy- can we do better? (Tang J, Zhu N, Rao S, Carlson KS) Best Pract Res Clin Haematol 2019 03;32(1):31-39 PMID: 30927973 SCOPUS ID: 2-s2.0-85061244660 04/01/2019       2 Citations
  • Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays. (Deshpande A, Chen BR, Zhao L, Saddoris K, Kerr M, Zhu N, Mali P, Deshpande AJ) J Vis Exp 2019 01 07(143) PMID: 30663717 01/22/2019    
  • PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. (Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D) Nat Commun 2017 11 13;8(1):1457 PMID: 29133930 PMCID: PMC5684131 SCOPUS ID: 2-s2.0-85034212045 11/15/2017       6 Citations
  • Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4. (Olp MD, Zhu N, Smith BC) Biochemistry 2017 10 17;56(41):5485-5495 PMID: 28945351 PMCID: PMC5970795 09/26/2017       5 Citations
  • Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. (Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T) Cell Rep 2016 Mar 01;14(8):1953-65 PMID: 26904942 PMCID: PMC4790111 02/26/2016       38 Citations
  • DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. (Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA) Nat Med 2015 Apr;21(4):335-43 PMID: 25822366 PMCID: PMC4390532 03/31/2015       109 Citations
  • AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. (Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA) Cancer Cell 2014 Dec 08;26(6):896-908 PMID: 25464900 PMCID: PMC4291116 12/04/2014       90 Citations
  • CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. (Huang CH, Lujambio A, Zuber J, Tschaharganeh DF, Doran MG, Evans MJ, Kitzing T, Zhu N, de Stanchina E, Sawyers CL, Armstrong SA, Lewis JS, Sherr CJ, Lowe SW) Genes Dev 2014 Aug 15;28(16):1800-14 PMID: 25128497 PMCID: PMC4197965 08/17/2014       94 Citations
  • Notch pathway activation targets AML-initiating cell homeostasis and differentiation. (Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I) J Exp Med 2013 Feb 11;210(2):301-19 PMID: 23359070 PMCID: PMC3570103 01/30/2013       93 Citations
  • STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2. (Tam WF, Hähnel PS, Schüler A, Lee BH, Okabe R, Zhu N, Pante SV, Raffel G, Mercher T, Wernig G, Bockamp E, Sasca D, Kreft A, Robinson GW, Hennighausen L, Gilliland DG, Kindler T) Cancer Res 2013 Jan 01;73(1):373-84 PMID: 23149921 PMCID: PMC3916953 11/15/2012       18 Citations
  • Polycomb repressive complex 2 is required for MLL-AF9 leukemia. (Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA) Proc Natl Acad Sci U S A 2012 Mar 27;109(13):5028-33 PMID: 22396593 PMCID: PMC3324004 03/08/2012       137 Citations
  • Chromatin-modifying enzymes as modulators of reprogramming. (Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ) Nature 2012 Mar 04;483(7391):598-602 PMID: 22388813 PMCID: PMC3501145 03/06/2012       418 Citations
  • Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. (Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH) Genes Dev 2012 Feb 15;26(4):344-9 PMID: 22345515 PMCID: PMC3289882 02/22/2012       91 Citations
  • A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells. (Liu J, Mercher T, Scholl C, Brumme K, Gilliland DG, Zhu N) Exp Hematol 2012 Jun;40(6):487-98.e3 PMID: 22306297 02/07/2012       17 Citations
  • MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. (Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, Feng Z, Punt N, Daigle A, Bullinger L, Pollock RM, Richon VM, Kung AL, Armstrong SA) Cancer Cell 2011 Jul 12;20(1):66-78 PMID: 21741597 PMCID: PMC3329803 07/12/2011       539 Citations
  • Transcriptional regulation by HMGN proteins. (Zhu N, Hansen U) Biochim Biophys Acta 2010 Jan-Feb;1799(1-2):74-9 PMID: 20123070 PMCID: PMC2818479 02/04/2010       15 Citations
  • HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors. (Zhu N, Hansen U) Mol Cell Biol 2007 Dec;27(24):8859-73 PMID: 17938209 PMCID: PMC2169410 10/17/2007       16 Citations
  • Last update: 09/21/2020
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